CN105287417A - Forsythia suspensa common anti-common-cold dispersible tablets and preparation method thereof - Google Patents
Forsythia suspensa common anti-common-cold dispersible tablets and preparation method thereof Download PDFInfo
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Abstract
The invention relates to forsythia suspensa common anti-common-cold dispersible tablets and a preparation method thereof, and belongs to the technical field of pharmacy. According to the present invention, the forsythia suspensa common anti-common-cold dispersible tablets are rich in the forsythia suspensa component, have effects of exterior syndrome relieving, cold removing, middle energizer warming and vomiting arresting, liver protection, cholaneresis, anti-inflammation, swelling subsiding, pain stopping, phlegm dissipating and cough stopping, and can treat wind-cold type common cold, gastrofrigid vomiting and cold-phlegm cough; the forsythia suspensa common anti-common-cold dispersible tablets have characteristics of scientific formula, easy taking, and good anti-common-cold effect; the preparation process is reasonable, the operability is strong, and the method is suitable for industrial production; a variety of herbs are compounded to promote and improve the efficacy and complement the disadvantage of the single herb, and the good heat clearing and cough stopping effect is provided; and the product has characteristics of good taste, significant effect and long shelf life.
Description
Technical field
The present invention relates to a kind of Fructus Forsythiae compounded anti-cold dispersible tablet and preparation side thereof, belong to pharmaceutical technology sectors.
Background technology
Chinese medicine is the rarity of the Chinese nation's 5,000 years traditional cultures, is the crystallization of medical practice in 1,100, is also the elite of world excellent culture.China has abundant Chinese material medicine resource, has the inherent advantage developing Chinese Medicine Industry.In recent years, China's Chinese Medicine Industry obtains and develops comparatively fast, and average annual growth rate reaches more than 20%.But from general status, the level of development of China's Chinese Medicine Industry is unsatisfactory.The data display that Institute Of Chinese Materia Medica Of China Academy of Chinese Medical Sciences provides, account for the China of world population 25.22%, medicinal industry only accounts for 7% of the whole world, the 3%-5% of natural drug Jin Zhan world natural drug market, 10% of the international Chinese herbal medicine market of Chinese medicine export amount deficiency, extremely unbecoming with the status of natural drug big country of China.
China's Chinese Medicine Industry, through the development of decades, has had certain scale and research and development ability, in Chinese crude drug, the prepared slices of Chinese crude drugs and dosage form etc., achieve certain achievement.But improving constantly along with people's living standard, and new health idea produces, the demand of domestic market to Chinese medicine increases rapidly, and the development of Chinese medicine is faced with huge ski-jump flow.
In addition, due to numerous Wild animal and plant resources critical shortage, excessively exploitation makes valuable Chinese material medicine resource be on the verge of exhaustion.The resources such as Cordyceps, Bulbus Fritillariae Cirrhosae, Rhizoma Coptidis are seriously damaged, and wild licorice reserves decrease 80%, and the wild individuality of medicinal herbs most in use Radix Ginseng, Radix Notoginseng has been difficult to find; The cultivation management of large traditional Chinese medicinal materials assortment is extensive, and per unit area yield is low, of poor quality; Insufficient to the research and development of genuine medicinal materials; The prevention and control of plant diseases, pest control of Chinese crude drug and chemical fertilizer, pesticide residual contamination problem are serious, and the instability of Chinese crude drug quality and the confusion of kind, make Chinese material medicine resource be far from accomplishing high-quality supply and sustainable use.
Fructus Forsythiae belongs to Oleaceae plants, and attribute is bitter, is slightly cold.Return lung, the heart, gallbladder meridian.Fructus Forsythiae has broad-spectrum antibacterial action, has very strong inhibitory action to staphylococcus aureus, Hayes dysentery bacterium, has certain inhibitory action to other pathogenic bacterium, influenza virus, fungus.There is antiinflammatory action.Oleanolic acid contained by this product has heart tonifying, diuresis and hypotensive activity, and Citrin can reduce vascular permeability and fragility, prevents haemolysis.Decoct has the town effect of telling, anti-liver injury effect.Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, dispelling wind and heat pathogens.Cure mainly carbuncle sore tumefacting virus, sucutaneous nodule scrofula, affection due to external wind and heat, epidemic febrile disease from the beginning of, the puckery pains of pyretic stranguria etc. are the Chinese medicine of important heat-clearing and toxic substances removing.
Existing Fructus Forsythiae cold medicine is mainly with the form of conventional tablet, granule, oral liquid, conventional tablet is often because disintegrate and drug-eluting slowly affect the abundant absorption of medicine, child, old man and the patient swallowing inconvenience have any problem when taking, when drug dose, larger or once take sheet number many time, problem is comparatively outstanding.Though oral liquid taking convenience, less stable, and not easily grasp taking dose.And dispersible tablet has the advantage of oral tablet, granule and oral liquid concurrently, good stability, is easy to carry, and taking convenience etc. have dispersion high, and dissolution rate is fast, absorption is fast, and bioavailability is high, and untoward reaction is few; Can swallow, chew, containing sucking, take separately or be equal to fruit juice, milk and take after also can being placed in water dispersion, the patient of especially applicable old man, child and solid difficulty of swallowing.
Therefore prepare a kind of good Fructus Forsythiae coldrex of applied widely, assimilation effect, become exigence.
Summary of the invention
Not enough for prior art, a kind of applied widely, good a kind of Fructus Forsythiae compounded anti-cold dispersible tablet of assimilation effect and the preparation method of preparation side thereof are provided.The method scientific formula, taking convenience, anti-flu is effective; Preparation technology is reasonable, strong operability, is applicable to suitability for industrialized production.
Technical scheme of the present invention:
Forsythia volatile oil after utilizing volatile oil extractor to extract microwave pretreatment, adopts homogenate extraction, microwave-assisted enzymolysis to obtain Radix Ophiopogonis, the Radix Angelicae Dahuricae, Fructus Jujubae, Folium perillae extract; Mix after Radix Ophiopogonis, the Radix Angelicae Dahuricae, Fructus Jujubae, the process of Folium perillae extract superfine powder as main active component with Forsythia volatile oil.Using starch and dextrin as filler, Pulvis Talci, as lubricant, using lactose, sodium alginate and carboxymethyl starch sodium as binding agent, disintegrating agent, prepares dispersible tablet.
Medicine of the present invention is made up of the Chinese medicine (weight portion) of following proportioning:
Medicine optimum proportioning of the present invention following (weight portion) composition:
Its preparation method is as follows:
(1), by Fructus Forsythiae, Radix Ophiopogonis, the Radix Angelicae Dahuricae, Fructus Jujubae and Folium Perillae select impurity, go mouldy product etc., and sieve dedust bits.Clear water washs rapidly, 60 ~ 95 DEG C of dryings.
(2), by Radix Ophiopogonis, the Radix Angelicae Dahuricae, Fructus Jujubae and Folium Perillae four kinds spray powder medical material and put into sterilizing cabinet 100 ~ 105 DEG C of sterilizings 1 hour, 65 ~ 75 DEG C of dryings in transposition heated-air circulation oven, pulverize dried medical material pulverizer, pulverize order number and are not less than 100 orders.
(3), with fresh Fructus Forsythiae for raw material, add 10 times of water making beating after cleaning, the microwave treatment power 800W time is 5 ~ 10min, then adopts volatile oil extractor to carry out extraction 5h, collects volatile oil.
(4), according to above-mentioned given ratio, by the medicinal residues of extraction in step 3 and Radix Ophiopogonis, the Radix Angelicae Dahuricae, 15 ~ 30min soaked by Fructus Jujubae and Folium Perillae four kinds of medicated powder spraying powder medicine, flash extracter is adopted to extract 3 times, extract voltage 80 ~ 100V, microwave-assisted cellulase degradation is adopted after extraction, microwave pretreatment power is 600 ~ 800W, mixing speed actuator is adjusted to middling speed, processing time 10 ~ 30min, treatment temperature is 50 ~ 55 DEG C, then cellulase 0.2% ~ 0.5% (medicinal residues and the Radix Ophiopogonis of 20000U/g is added, the Radix Angelicae Dahuricae, Fructus Jujubae and Folium Perillae four kinds beat powder medicine percentage by weight) processing time is 1 ~ 2h, centrifugal, 60 DEG C are evaporated to every milliliter and are equivalent to crude drug 2g, slowly add ethanol and reach 60% to determining alcohol, hold over night, centrifugal supernatant, 60 DEG C are carried out drying under reduced pressure, reclaim ethanol, concentrated, 80 DEG C of drying under reduced pressure, obtain extractum.
(5), by extract in step 4 carry out superfine powder process, then mix according to 50:1 ratio with Forsythia volatile oil.
(6), using starch and dextrin as filler, Pulvis Talci, as lubricant, using lactose, sodium alginate and carboxymethyl starch sodium as binding agent, disintegrating agent, prepares dispersible tablet.After medicine and adjuvant fully mix, granulate with 75% ethanol wet, cross 20 mesh sieves, 60 DEG C of drying under reduced pressure, granulate, adopt tablet machine compacting dispersible tablet.
Beneficial effect of the present invention is:
1, Fructus Forsythiae compounded anti-cold dispersible tablet provided by the present invention is rich in Forsythia suspensa ingredients, has the effect of the cold expelling that induces sweat, warming middle-JIAO to arrest vomiting, hepatic cholagogic, anti-inflammatory, repercussive and analgesic, preventing phlegm from forming and stopping coughing, can control anemofrigid cold, gastrofrigid vomiting, cold-phlegm cough.
2, Fructus Forsythiae compounded anti-cold dispersible tablet scientific formula provided by the present invention, taking convenience, anti-flu is effective; Preparation technology is reasonable, strong operability, is applicable to suitability for industrialized production.
3, the composite mutual promotion of multiple medical material improves drug effect, supplements the deficiency of single medical material, has good reducing fever relieving cough effect.Products taste is good, has a significant effect, long shelf-life.
Detailed description of the invention
Further illustrate technical scheme of the present invention below in conjunction with embodiment, specific embodiment does not limit the present invention.
Embodiment 1:
A kind of Fructus Forsythiae compounded anti-cold dispersible tablet is obtained by following raw material:
The preparation method of described Fructus Forsythiae compounded anti-cold dispersible tablet is as follows:
(1), by Fructus Forsythiae, Radix Ophiopogonis, the Radix Angelicae Dahuricae, Fructus Jujubae and Folium Perillae select impurity, go mouldy product etc., and sieve dedust bits.Clear water washs rapidly, 60 ~ 95 DEG C of dryings.
(2), by Radix Ophiopogonis, the Radix Angelicae Dahuricae, Fructus Jujubae and Folium Perillae four kinds spray powder medical material and put into sterilizing cabinet 100 ~ 105 DEG C of sterilizings 1 hour, 65 ~ 75 DEG C of dryings in transposition heated-air circulation oven, pulverize dried medical material pulverizer, pulverize order number and are not less than 100 orders.
(3), with fresh Fructus Forsythiae for raw material, add 10 times of water making beating after cleaning, the microwave treatment power 800W time is 5 ~ 10min, then adopts volatile oil extractor to carry out extraction 5h, collects volatile oil.
(4), according to above-mentioned given ratio, by the medicinal residues of extraction in step 3 and Radix Ophiopogonis, the Radix Angelicae Dahuricae, 15 ~ 30min soaked by Fructus Jujubae and Folium Perillae four kinds of medicated powder spraying powder medicine, flash extracter is adopted to extract 3 times, extract voltage 80 ~ 100V, microwave-assisted cellulase degradation is adopted after extraction, microwave pretreatment power is 600 ~ 800W, mixing speed actuator is adjusted to middling speed, processing time 10 ~ 30min, treatment temperature is 50 ~ 55 DEG C, then cellulase 0.2% ~ 0.5% (medicinal residues and the Radix Ophiopogonis of 20000U/g is added, the Radix Angelicae Dahuricae, Fructus Jujubae and Folium Perillae four kinds beat powder medicine percentage by weight) processing time is 1 ~ 2h, centrifugal, 60 DEG C are evaporated to every milliliter and are equivalent to crude drug 2g, slowly add ethanol and reach 60% to determining alcohol, hold over night, centrifugal supernatant, 60 DEG C are carried out drying under reduced pressure, reclaim ethanol, concentrated, 80 DEG C of drying under reduced pressure, obtain extractum.
(5), by extract in step 4 carry out superfine powder process, then mix according to 50:1 ratio with Forsythia volatile oil.
(6), using starch and dextrin as filler, Pulvis Talci, as lubricant, using lactose, sodium alginate and carboxymethyl starch sodium as binding agent, disintegrating agent, prepares dispersible tablet.After medicine and adjuvant fully mix, granulate with 75% ethanol wet, cross 20 mesh sieves, 60 DEG C of drying under reduced pressure, granulate, adopt tablet machine compacting dispersible tablet.
Embodiment 2:
A kind of Fructus Forsythiae compounded anti-cold dispersible tablet is obtained by following raw material:
The preparation method of described Fructus Forsythiae compounded anti-cold dispersible tablet is as follows:
(1), by Fructus Forsythiae, Radix Ophiopogonis, the Radix Angelicae Dahuricae, Fructus Jujubae and Folium Perillae select impurity, go mouldy product etc., and sieve dedust bits.Clear water washs rapidly, 60 ~ 95 DEG C of dryings.
(2), by Radix Ophiopogonis, the Radix Angelicae Dahuricae, Fructus Jujubae and Folium Perillae four kinds spray powder medical material and put into sterilizing cabinet 100 ~ 105 DEG C of sterilizings 1 hour, 65 ~ 75 DEG C of dryings in transposition heated-air circulation oven, pulverize dried medical material pulverizer, pulverize order number and are not less than 100 orders.
(3), with fresh Fructus Forsythiae for raw material, add 10 times of water making beating after cleaning, the microwave treatment power 800W time is 5 ~ 10min, then adopts volatile oil extractor to carry out extraction 5h, collects volatile oil.
(4), according to above-mentioned given ratio, by the medicinal residues of extraction in step 3 and Radix Ophiopogonis, the Radix Angelicae Dahuricae, 15 ~ 30min soaked by Fructus Jujubae and Folium Perillae four kinds of medicated powder spraying powder medicine, flash extracter is adopted to extract 3 times, extract voltage 80 ~ 100V, microwave-assisted cellulase degradation is adopted after extraction, microwave pretreatment power is 600 ~ 800W, mixing speed actuator is adjusted to middling speed, processing time 10 ~ 30min, treatment temperature is 50 ~ 55 DEG C, then cellulase 0.2% ~ 0.5% (medicinal residues and the Radix Ophiopogonis of 20000U/g is added, the Radix Angelicae Dahuricae, Fructus Jujubae and Folium Perillae four kinds beat powder medicine percentage by weight) processing time is 1 ~ 2h, centrifugal, 60 DEG C are evaporated to every milliliter and are equivalent to crude drug 2g, slowly add ethanol and reach 60% to determining alcohol, hold over night, centrifugal supernatant, 60 DEG C are carried out drying under reduced pressure, reclaim ethanol, concentrated, 80 DEG C of drying under reduced pressure, obtain extractum.
(5), by extract in step 4 carry out superfine powder process, then mix according to 50:1 ratio with Forsythia volatile oil.
(6), using starch and dextrin as filler, Pulvis Talci, as lubricant, using lactose, sodium alginate and carboxymethyl starch sodium as binding agent, disintegrating agent, prepares dispersible tablet.After medicine and adjuvant fully mix, granulate with 75% ethanol wet, cross 20 mesh sieves, 60 DEG C of drying under reduced pressure, granulate, adopt tablet machine compacting dispersible tablet.
Embodiment 3:
A kind of Fructus Forsythiae compounded anti-cold dispersible tablet is obtained by following raw material:
The preparation method of described Fructus Forsythiae compounded anti-cold dispersible tablet is as follows:
(1), by Fructus Forsythiae, Radix Ophiopogonis, the Radix Angelicae Dahuricae, Fructus Jujubae and Folium Perillae select impurity, go mouldy product etc., and sieve dedust bits.Clear water washs rapidly, 60 ~ 95 DEG C of dryings.
(2), by Radix Ophiopogonis, the Radix Angelicae Dahuricae, Fructus Jujubae and Folium Perillae four kinds spray powder medical material and put into sterilizing cabinet 100 ~ 105 DEG C of sterilizings 1 hour, 65 ~ 75 DEG C of dryings in transposition heated-air circulation oven, pulverize dried medical material pulverizer, pulverize order number and are not less than 100 orders.
(3), with fresh Fructus Forsythiae for raw material, add 10 times of water making beating after cleaning, the microwave treatment power 800W time is 5 ~ 10min, then adopts volatile oil extractor to carry out extraction 5h, collects volatile oil.
(4), according to above-mentioned given ratio, by the medicinal residues of extraction in step 3 and Radix Ophiopogonis, the Radix Angelicae Dahuricae, 15 ~ 30min soaked by Fructus Jujubae and Folium Perillae four kinds of medicated powder spraying powder medicine, flash extracter is adopted to extract 3 times, extract voltage 80 ~ 100V, microwave-assisted cellulase degradation is adopted after extraction, microwave pretreatment power is 600 ~ 800W, mixing speed actuator is adjusted to middling speed, processing time 10 ~ 30min, treatment temperature is 50 ~ 55 DEG C, then cellulase 0.2% ~ 0.5% (medicinal residues and the Radix Ophiopogonis of 20000U/g is added, the Radix Angelicae Dahuricae, Fructus Jujubae and Folium Perillae four kinds beat powder medicine percentage by weight) processing time is 1 ~ 2h, centrifugal, 60 DEG C are evaporated to every milliliter and are equivalent to crude drug 2g, slowly add ethanol and reach 60% to determining alcohol, hold over night, centrifugal supernatant, 60 DEG C are carried out drying under reduced pressure, reclaim ethanol, concentrated, 80 DEG C of drying under reduced pressure, obtain extractum.
(5), by extract in step 4 carry out superfine powder process, then mix according to 50:1 ratio with Forsythia volatile oil.
(6), using starch and dextrin as filler, Pulvis Talci, as lubricant, using lactose, sodium alginate and carboxymethyl starch sodium as binding agent, disintegrating agent, prepares dispersible tablet.After medicine and adjuvant fully mix, granulate with 75% ethanol wet, cross 20 mesh sieves, 60 DEG C of drying under reduced pressure, granulate, adopt tablet machine compacting dispersible tablet.
Claims (6)
1. a Fructus Forsythiae compounded anti-cold dispersible tablet, is made up of following raw material, and described number is weight portion:
2. a kind of Fructus Forsythiae compounded anti-cold dispersible tablet as claimed in claim 1, it is characterized in that: be made up of following raw material, described number is weight portion:
3. the preparation method of a kind of Fructus Forsythiae compounded anti-cold dispersible tablet as claimed in claim 1, is characterized in that:
1), by Fructus Forsythiae, Radix Ophiopogonis, the Radix Angelicae Dahuricae, Fructus Jujubae and Folium Perillae select impurity, go mouldy product etc., and sieve dedust bits; Clear water washs rapidly, 60 ~ 95 DEG C of dryings;
2), by Radix Ophiopogonis, the Radix Angelicae Dahuricae, Fructus Jujubae and Folium Perillae four kinds spray powder medical material and put into sterilizing cabinet 100 ~ 105 DEG C of sterilizings 1 hour, 65 ~ 75 DEG C of dryings in transposition heated-air circulation oven, pulverize dried medical material pulverizer, pulverize order number and are not less than 100 orders;
3), with fresh Fructus Forsythiae for raw material, add 10 times of water making beating after cleaning, microwave treatment 5 ~ 10min, then adopt volatile oil extractor to carry out extraction 5h, collect volatile oil;
4), according to above-mentioned given ratio, by the medicinal residues of extraction in step 3 and Radix Ophiopogonis, the Radix Angelicae Dahuricae, 15 ~ 30min soaked by Fructus Jujubae and Folium Perillae four kinds of medicated powder spraying powder medicine, flash extracter is adopted to extract 3 times, extract voltage 80 ~ 100V, microwave-assisted cellulase degradation is adopted after extraction, after microwave pretreatment, mixing speed actuator is adjusted to middling speed, stir process time 10 ~ 30min, treatment temperature is 50 ~ 55 DEG C, then cellulase 0.2% ~ 0.5% (medicinal residues and the Radix Ophiopogonis of 20000U/g is added, the Radix Angelicae Dahuricae, Fructus Jujubae and Folium Perillae four kinds beat powder medicine percentage by weight) processing time is 1 ~ 2h, centrifugal, 60 DEG C are evaporated to every milliliter and are equivalent to crude drug 2g, slowly add ethanol and reach 60% to determining alcohol, hold over night, centrifugal supernatant, 60 DEG C are carried out drying under reduced pressure, reclaim ethanol, concentrated, 80 DEG C of drying under reduced pressure, obtain extractum,
5), by extract in step 4 carry out superfine powder process, then mix with Forsythia volatile oil;
6), using starch and dextrin as filler, Pulvis Talci, as lubricant, using lactose, sodium alginate and carboxymethyl starch sodium as binding agent, disintegrating agent, prepares dispersible tablet; After medicine and adjuvant fully mix, granulate with 75% ethanol wet, cross 20 mesh sieves, 60 DEG C of drying under reduced pressure, granulate, adopt tablet machine compacting dispersible tablet.
4. the preparation method of a kind of Fructus Forsythiae compounded anti-cold dispersible tablet as claimed in claim 3, is characterized in that: step 3) middle microwave treatment power 800W.
5. the preparation method of a kind of Fructus Forsythiae compounded anti-cold dispersible tablet as claimed in claim 3, is characterized in that: step 4) in microwave pretreatment power be 600 ~ 800W.
6. the preparation method of a kind of Fructus Forsythiae compounded anti-cold dispersible tablet as claimed in claim 3, is characterized in that: step 5) extract to mix with Forsythia volatile oil after carrying out superfine powder process and mixes according to the ratio of 50:1.
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CN1107057A (en) * | 1994-08-16 | 1995-08-23 | 欧致新 | Children coryza medicine and preparing method |
CN1927342A (en) * | 2006-09-05 | 2007-03-14 | 江西本草天工科技有限责任公司 | Heat clearing and detoxicating dispersant tablet and method for making same |
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