CN105148240A - Medicinal preparation used for treating chronic cardiac failure - Google Patents
Medicinal preparation used for treating chronic cardiac failure Download PDFInfo
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- CN105148240A CN105148240A CN201510641599.1A CN201510641599A CN105148240A CN 105148240 A CN105148240 A CN 105148240A CN 201510641599 A CN201510641599 A CN 201510641599A CN 105148240 A CN105148240 A CN 105148240A
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Abstract
The invention belongs to the field of Chinese herb preparations, and particularly provides a medicinal preparation used for treating the chronic cardiac failure. The medicinal preparation is prepared from 28 parts of perilla frutescens (L.) britton var. crispa (thunb.) decne, 25 parts of torpedograss roots, 20 parts of thyme, 25 parts of amur grape stems, 15 parts of biden bipinnata, 25 parts of salvia miltiorrhiza, 28 parts of semen lepidii, 15 parts of rhizoma zingiberis, 15 parts of beautiful sweetgum fruits, 20 parts of radix astragali, 25 parts of leeches, 20 parts of rhizoma sparganii, 25 parts of poria cocos, 20 parts of Chinese pulsatilla roots, 15 parts of radix paeoniae alba, 15 parts of radix puerariae, 15 parts of rhizoma atractylodis macrocephalae, 25 parts of codonopsis pilosula, 15 parts of folium mori and 5 parts of glycyrrhiza uralensis. The medicinal preparation is capable of treating the chronic cardiac failure.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, be specifically related to a kind of pharmaceutical preparation being used for the treatment of chronic heart failure and its preparation method and application.
Background technology
Heart failure is the myocardial damage because any reasons such as myocardial infarction, cardiomyopathy, hemodynamics overload, inflammation cause, and causes the change of cardiac structure and function, finally causes ventricular pump blood or full hypofunction.Clinical main manifestations is dyspnea, weak and body retention.Chronic heart failure (CHF) refers to the heart failure state of sustainable existence, can stablize, worsens or lose compensatory.The target for the treatment of heart failure is not only and is improved symptom, improves the quality of living, and for the mechanism of myocardial remodelling, delays and prevent the development of myocardial remodelling, reduce admission rate and the mortality rate of heart failure.For this reason, the needs that the medicine developing more chronic heart failure safely and effectively meets clinical treatment are bursting to.
Summary of the invention
In order to solve the problem, the object of the present invention is to provide a kind of can the Chinese medicine preparation of chronic heart failure disease.In order to reach this object, adopt following technical scheme:
Technical scheme: a kind of pharmaceutical preparation being used for the treatment of chronic heart failure, the active component contained by it by following raw materials in part by weight medicine extract be prepared from: cockscomb Folium Perillae 28 parts, Radix Panici miliacei 25 parts, Herba thymi vulgaris 20 parts, Caulis Vitis Amurensis 25 parts, Herba bidentis parviflorae 15 parts, Radix Salviae Miltiorrhizae 25 parts, Semen Lepidii (Semen Descurainiae) 28 parts, Rhizoma Zingiberis 15 parts, Fructus Liquidambaris 15 parts, the Radix Astragali 20 parts, Hirudo 25 parts, Rhizoma Sparganii 20 parts, 25 parts, Poria, the Radix Pulsatillae 20 parts, the Radix Paeoniae Alba 15 parts, Radix Puerariae 15 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, Radix Codonopsis 25 parts, 15 parts, Folium Mori, 5 parts, Radix Glycyrrhizae.
The described pharmaceutical preparation being used for the treatment of chronic heart failure, dosage form is pharmaceutically acceptable granule, tablet, capsule.
The described pharmaceutical preparation being used for the treatment of chronic heart failure, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
The described application of pharmaceutical preparation in preparation chronic heart failure medicine being used for the treatment of chronic heart failure.
Cockscomb Folium Perillae, Latin is called Perillafrutescens (L.) Brittonvar.crispa (Thunb.) Decne., Labiatae Perilla plant.Annual herb, the special fragrance of tool.Deliver, cold expelling, regulate the flow of vital energy, and battalion.Cure cold wind and cold, fever with aversion to cold, cough, asthma, distension and fullness of the chest and abdomen etc.The present invention is with all herbal medicine.
Ground Radix Panici miliacei is rhizome and the root of grass Herba panici repentics, has effect of heat clearing away suppressing the hyperactive liver, eliminating damp, detoxifying.
Herba thymi vulgaris is the thymy herb of labiate.Antitussive.Especially effective to pertussis.For acute bronchitis, laryngitis.
Caulis Vitis Amurensis is root or the ratan of vitaceae Vitis Amurensis.Chinese formal name used at school: Caulis Vitis Amurensis Classification system VitisamurensisRupr, autumn, winter gather, and clean, and section or section, dry.Root, rattan: wind-expelling pain-stopping.For the outer pain of injury, rheumatic ostalgia, stomachache, stomachache, nervous headache, postoperative pain.Really: clearing away heat and promoting diuresis.Thirsty for dysphoria with smothery sensation, urinary tract infection, dysuria.The present invention is used as medicine with root.
Herba bidentis parviflorae, Latin is called BidensbipinnataL., Compositae, Herba bidentis parviflorae platymiscium, and Herba bidentis parviflorae is born in hillside, meadow or roadside more.Be widely distributed in all parts of the country.Wanda Mountain district quantity is more.With all herbal medicine.Gather during summer-flowering, cutting, dries.Heat-clearing and toxic substances removing, expelling wind and activating blood circulation.For upper respiratory tract infection, laryngopharynx swelling and pain, acute appendicitis, acute icteric infectious hepatitis, gastroenteritis, dyspepsia, rheumatic arthritis, malaria; Furuncle is controlled in external, venom, treating swelling and pain by traumatic injury.The present invention is with all herbal medicine.All the other Chinese medicines are pharmacopeia kind.
Beneficial effect: the traditional Chinese medical science is thought, chronic heart failure mostly is deficiency of heart-YANG, deficiency of heart-QI, cockscomb Folium Perillae of the present invention, Radix Panici miliacei, Herba thymi vulgaris, Caulis Vitis Amurensis, Herba bidentis parviflorae, Radix Salviae Miltiorrhizae, Semen Lepidii (Semen Descurainiae), Rhizoma Zingiberis, Fructus Liquidambaris, Radix Astragali QI invigorating warming YANG, heat-clearing and toxic substances removing, depressed liver-energy dispersing and QI regulating be monarch drug, Hirudo, Rhizoma Sparganii, Poria, the Radix Pulsatillae, the Radix Paeoniae Alba, Radix Puerariae, the Rhizoma Atractylodis Macrocephalae, Radix Codonopsis, Folium Mori blood circulation promoting and blood stasis dispelling, channels sootheing and network vessel quickening are ministerial drug, Radix Glycyrrhizae is adjuvant, full side compatibility mutually, chronic heart failure successful.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
1, the preparation of granule embodiment: get cockscomb Folium Perillae 28g, ground Radix Panici miliacei 25g, Herba thymi vulgaris 20g, Caulis Vitis Amurensis 25g, Herba bidentis parviflorae 15g, Radix Salviae Miltiorrhizae 25g, Semen Lepidii (Semen Descurainiae) 28g, Rhizoma Zingiberis 15g, Fructus Liquidambaris 15g, Radix Astragali 20g, Hirudo 25g, Rhizoma Sparganii 20g, Poria 25g, Radix Pulsatillae 20g, Radix Paeoniae Alba 15g, Radix Puerariae 15g, Rhizoma Atractylodis Macrocephalae 15g, Radix Codonopsis 25g, Folium Mori 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, and atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, make granule.
2, the preparation of Tablets Example: get cockscomb Folium Perillae 28g, ground Radix Panici miliacei 25g, Herba thymi vulgaris 20g, Caulis Vitis Amurensis 25g, Herba bidentis parviflorae 15g, Radix Salviae Miltiorrhizae 25g, Semen Lepidii (Semen Descurainiae) 28g, Rhizoma Zingiberis 15g, Fructus Liquidambaris 15g, Radix Astragali 20g, Hirudo 25g, Rhizoma Sparganii 20g, Poria 25g, Radix Pulsatillae 20g, Radix Paeoniae Alba 15g, Radix Puerariae 15g, Rhizoma Atractylodis Macrocephalae 15g, Radix Codonopsis 25g, Folium Mori 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds dextrin 50g, granulates, tabletting, makes tablet.
3, the preparation of capsule embodiment: get cockscomb Folium Perillae 28g, ground Radix Panici miliacei 25g, Herba thymi vulgaris 20g, Caulis Vitis Amurensis 25g, Herba bidentis parviflorae 15g, Radix Salviae Miltiorrhizae 25g, Semen Lepidii (Semen Descurainiae) 28g, Rhizoma Zingiberis 15g, Fructus Liquidambaris 15g, Radix Astragali 20g, Hirudo 25g, Rhizoma Sparganii 20g, Poria 25g, Radix Pulsatillae 20g, Radix Paeoniae Alba 15g, Radix Puerariae 15g, Rhizoma Atractylodis Macrocephalae 15g, Radix Codonopsis 25g, Folium Mori 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds starch 50g, granulates, fill, makes capsule.
4, pharmaceutical preparation chronic heart failure of the present invention clinical research
4.1 general data: this pharmaceutical preparation is applied to clinical observation chronic heart failure case 50 example, 56 ~ 75 years old age.The shortest person of the course of disease 6 months, most elder reaches 2 years.
4.2 diagnostic criterias: 1. meet coronary heart disease, hypertensive heart disease, the diagnostic criteria of left heart failure and Chinese medical discrimination person.2. cardiac functional grading II-III level.3. the sign of traditional Chinese medical science deficiency of both QI and YIN blood stasis causing water retention is met.Choose the dialectical deficiency of both QI and YIN blood stasis causing water retention person of levying with reference to " new Chinese medicine guideline of clinical investigations ", card is shown in: cardiopalmus, very then dyspnea with rapid breath of breathing hard, sensation of oppression and faint pain in the chest, time when doing only, fatigue and weakness, pale complexion or dark and gloomy, cyanotic lips, costa sternales is full vexed, mass in the abdomen under rib, edema, xerostomia, tongue has speckle, few tongue or exfoliative fur, thready and weak pulse, tcm syndrome grading standard (adopting the method for integration); Slight: integration≤17 point; Moderate: integration >=18 point≤33 points; Integration >=34.
4.3 test methods: prepare clinical sample by above-mentioned process for producing granula, specification is 10 grams every bag, within five days, is a course for the treatment of, one day three bags, take point early, middle and late three half an hour ante cibum.Period in a medicine is avoided eating anything raw or cold, pungent, stimulate and rotten thing.Blank group oral placebo granule five days is a course for the treatment of, one day three bags, point early, middle and late three half an hour ante cibum take.
4.4 criterions of therapeutical effect:: 1. clinical recent healing: after treatment, syndrome integral reduces >=85%; 2. effective: after treatment, syndrome integral reduces by >=70% < 85%; 3. effective: after treatment, syndrome integral reduces by >=30% < 70%; 4. invalid: after treatment, integration reduces < 30%.
4.5 therapeutic effect: in table 1.
Table 1 liang group comparitive study
| Group | n | Clinical recent healing | Effective | Effectively | Invalid | Total effective rate (%) |
| Treatment group | 25 | 8 | 5 | 10 | 2 | 92 |
| Blank group | 25 | 1 | 1 | 0 | 23 | 8 |
Visible, the medicine that the present invention obtains can safe and effective chronic heart failure, and has no side effect.
Claims (4)
1. one kind is used for the treatment of the pharmaceutical preparation of chronic heart failure, it is characterized in that, the active component contained by it by following raw materials in part by weight medicine extract be prepared from: cockscomb Folium Perillae 28 parts, Radix Panici miliacei 25 parts, Herba thymi vulgaris 20 parts, Caulis Vitis Amurensis 25 parts, Herba bidentis parviflorae 15 parts, Radix Salviae Miltiorrhizae 25 parts, Semen Lepidii (Semen Descurainiae) 28 parts, Rhizoma Zingiberis 15 parts, Fructus Liquidambaris 15 parts, the Radix Astragali 20 parts, Hirudo 25 parts, Rhizoma Sparganii 20 parts, 25 parts, Poria, the Radix Pulsatillae 20 parts, the Radix Paeoniae Alba 15 parts, Radix Puerariae 15 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, Radix Codonopsis 25 parts, 15 parts, Folium Mori, 5 parts, Radix Glycyrrhizae.
2. be used for the treatment of the pharmaceutical preparation of chronic heart failure as claimed in claim 1, it is characterized in that, dosage form is pharmaceutically acceptable granule, tablet, capsule.
3. be used for the treatment of the pharmaceutical preparation of chronic heart failure as claimed in claim 1, it is characterized in that, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
4. be used for the treatment of the application of pharmaceutical preparation in chronic heart failure medicine of chronic heart failure according to claim 1.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109419864A (en) * | 2017-08-22 | 2019-03-05 | 北京中医药大学 | The new application of the Chinese bulbul |
| CN110115309A (en) * | 2019-06-29 | 2019-08-13 | 广东云瑶生物医药科技有限公司 | A kind of preparation method and applications of Sang Sucha |
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| CN1927331A (en) * | 2006-01-25 | 2007-03-14 | 宋春光 | Chinese medicine preparation for curing chronic heart failure |
| CN102526611A (en) * | 2011-12-19 | 2012-07-04 | 刘兆霞 | Chinese medicinal composition for treating chronic heart failure |
| CN104095945A (en) * | 2014-08-04 | 2014-10-15 | 段希福 | Traditional Chinese medicine composition for treating chronic cardiac failure and oral preparation thereof |
| CN104784618A (en) * | 2015-04-23 | 2015-07-22 | 淄博齐鼎立专利信息咨询有限公司 | Traditional Chinese medicine composition for treating headache |
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Patent Citations (4)
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| CN1927331A (en) * | 2006-01-25 | 2007-03-14 | 宋春光 | Chinese medicine preparation for curing chronic heart failure |
| CN102526611A (en) * | 2011-12-19 | 2012-07-04 | 刘兆霞 | Chinese medicinal composition for treating chronic heart failure |
| CN104095945A (en) * | 2014-08-04 | 2014-10-15 | 段希福 | Traditional Chinese medicine composition for treating chronic cardiac failure and oral preparation thereof |
| CN104784618A (en) * | 2015-04-23 | 2015-07-22 | 淄博齐鼎立专利信息咨询有限公司 | Traditional Chinese medicine composition for treating headache |
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| 陈守强等: "名老中医治疗心力衰竭验案用药规律的varclus聚类分析", 《辽宁中医杂志》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109419864A (en) * | 2017-08-22 | 2019-03-05 | 北京中医药大学 | The new application of the Chinese bulbul |
| CN110115309A (en) * | 2019-06-29 | 2019-08-13 | 广东云瑶生物医药科技有限公司 | A kind of preparation method and applications of Sang Sucha |
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Application publication date: 20151216 |