CN105125896A - Pharmaceutical preparation for treating migraine - Google Patents
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- CN105125896A CN105125896A CN201510634436.0A CN201510634436A CN105125896A CN 105125896 A CN105125896 A CN 105125896A CN 201510634436 A CN201510634436 A CN 201510634436A CN 105125896 A CN105125896 A CN 105125896A
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention belongs to the field of traditional Chinese medicine preparations, and particularly provides a pharmaceutical preparation for treating migraine. The pharmaceutical preparation is prepared from 25 parts of maidenhair spleenwort, 20 parts of murraya euchrestifolia, 28 parts of fruticose breynia juvenile branchlets and leaves, 25 parts of herba violae, 25 parts of radix angelicae, 28 parts of saposhnikovia divaricata, 15 parts of rabdosia rubescens, 15 parts of corydalis tubers, 20 parts of peach kernels, 25 parts of salvia miltiorrhiza, 20 parts of safflower carthamus, 25 parts of fructus viticis, 20 parts of mint, 15 parts of frankincense, 15 parts of myrrh, 15 parts of radix bupleuri, 25 parts of pinellia ternate, 15 parts of gastrodia elata and 5 parts of liquorice. The pharmaceutical preparation can treat the migraine.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, be specifically related to one and be used for the treatment of migrainous pharmaceutical preparation and its preparation method and application.
Background technology
Migraine is clinical modal primary headache type; clinical with ictal middle severe, sample of beating headache for main manifestations; headache mostly is inclined side; general lasting 4 ~ 72 hours; can with Nausea and vomiting; light, Sound stimulat or daily routines all can increase the weight of headache, and quiet environment, rest can alleviate headache.Migraine is a kind of common chronic forms vascular illness, and a lot of disease is in child and adolescence, and the young and middle-aged phase reaches onset peak, and women is common, and men and women's Proportion of patients is about 1: 2 ~ 3, and in crowd, prevalence is 5% ~ 10%, often has genetic background.For this reason, be bursting to develop and manyly treat the needs that migrainous medicine meets clinical treatment safely and effectively.
Summary of the invention
In order to solve the problem, the object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of migraine disease.In order to reach this object, adopt following technical scheme:
Technical scheme: one is used for the treatment of migrainous pharmaceutical preparation, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Herba asplenii trichomanis 25 parts, tetramerous jasminorange leaf 20 parts, Folium et cacumen Breyniae Fruticosae 28 parts, little Lan flower Herba Violae 25 parts, the Radix Angelicae Dahuricae 25 parts, Radix Saposhnikoviae 28 parts, Rabdosia rubescens 15 parts, Rhizoma Corydalis 15 parts, 20 parts, Semen Persicae, Radix Salviae Miltiorrhizae 25 parts, 20 parts, Flos Carthami, Fructus Viticis 25 parts, Herba Menthae 20 parts, Olibanum 15 parts, Myrrha 15 parts, Radix Bupleuri 15 parts, the Rhizoma Pinelliae 25 parts, 15 parts, Rhizoma Gastrodiae, 5 parts, Radix Glycyrrhizae.
Describedly be used for the treatment of migrainous pharmaceutical preparation, dosage form is pharmaceutically acceptable granule, tablet, capsule.
Describedly be used for the treatment of migrainous pharmaceutical preparation, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
Described be used for the treatment of migrainous pharmaceutical preparation preparation treatment migraine remedy in application.
Herba asplenii trichomanis is fern Aspleniaceae spleen wort Asplenium trchomanes L. AspleniumtrichomanesL., with all herbal medicine.The four seasons can adopt, and clean, using fresh herb or dry.Heat-clearing and toxic substances removing, regulating menstruation, hemostasis, convergence leukorrhagia stopping.For infantile hyperpyrexia, leucorrhea, menoxenia; Burn and scald is controlled in external, traumatic hemorrhage, furuncle swelling toxin, venom.
Tetramerous jasminorange leaf is Rutaceae Murraya plant tetramerous jasminorange leaf MurrayatetrameraHuang, is used as medicine with Ye Hegen.The picking leaves of autumn in summer, autumn adopts root, cleans cutting, all can using fresh herb or dry in the shade for subsequent use.Expelling pathogenic wind from the body surface, promoting the circulation of QI to relieve pain, promoting blood circulation to remove blood stasis.For cold, fever, bronchitis, asthma, rheumatic numbness, bones and muscles pain, traumatic injury swelling and pain due to blood stasis, skin pruritus, eczema, venom, malaria, stomachache, edema etc.The present invention is used as medicine with leaf.
Folium et cacumen Breyniae Fruticosae is the browse of euphorbia plant Folium et cacumen Breyniae Fruticosae.Upright shrub, high 2 ~ 3 meters.Bark taupe brown, branch is cylindric, multi-fork sigmoid, the tiny hole skin of surperficial adularescent.Heat-clearing and toxic substances removing, dissipating blood stasis, pain relieving, antipruritic.Root: acute gastroenteritis, tonsillitis, bronchitis, lithangiuria, puerperal uterine contraction pain, rheumatic arthritis.Leaf: burn and scald is controlled in external, eczema, allergic dermatitis, skin itching, vaginitis.
Little Lan flower Herba Violae is the little Radix Polygalae PolygalasibiricaL.var.megalophaFranch. of Polygalaceae polygala, is used as medicine with Herb.The whole year can adopt, and chopping is dried.Antiinflammatory, pain relieving, draws out pus by applying a plaster to the affected part, granulation promoting.For parotitis, infantile pneumonia, gastroenteritis, stomachache, furuncle, toothache, bones and muscles pain due to rheumatism; Skin ulcer, furuncle are controlled in external, stremma, traumatic injury impairment caused by overstrain.All the other Chinese medicines are pharmacopeia kind.
Beneficial effect: the traditional Chinese medical science is thought, migraine mostly is all wind trembling and dizziness, all belong to liver, liver is lost bar and reaches, liver-yang is partially high, follow through on disturb key clearly, Herba asplenii trichomanis of the present invention, tetramerous jasminorange leaf, Folium et cacumen Breyniae Fruticosae, little Lan flower Herba Violae, the Radix Angelicae Dahuricae, Radix Saposhnikoviae, Rabdosia rubescens, Rhizoma Corydalis, Semen Persicae, Radix Salviae Miltiorrhizae, Flos Carthami heat-clearing and toxic substances removing, sedation-analgesia, dredge the meridian passage is monarch drug, Fructus Viticis, Herba Menthae, Olibanum, Myrrha, Radix Bupleuri, the Rhizoma Pinelliae, Rhizoma Gastrodiae wind-dispelling heat-dissipating, clearing away heat and expelling pathogen in the exterior is ministerial drug, Radix Glycyrrhizae is adjuvant, the mutual compatibility of full side, sedation-analgesia, dredge the meridian passage, clearing away heat and expelling pathogen in the exterior, treatment migraine successful.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
1, the preparation of granule embodiment: get Herba asplenii trichomanis 25g, tetramerous jasminorange leaf 20g, Folium et cacumen Breyniae Fruticosae 28g, little Lan flower Herba Violae 25g, Radix Angelicae Dahuricae 25g, Radix Saposhnikoviae 28g, Rabdosia rubescens 15g, Rhizoma Corydalis 15g, Semen Persicae 20g, Radix Salviae Miltiorrhizae 25g, Flos Carthami 20g, Fructus Viticis 25g, Herba Menthae 20g, Olibanum 15g, Myrrha 15g, Radix Bupleuri 15g, Rhizoma Pinelliae 25g, Rhizoma Gastrodiae 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, and atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, make granule.
2, the preparation of Tablets Example: get Herba asplenii trichomanis 25g, tetramerous jasminorange leaf 20g, Folium et cacumen Breyniae Fruticosae 28g, little Lan flower Herba Violae 25g, Radix Angelicae Dahuricae 25g, Radix Saposhnikoviae 28g, Rabdosia rubescens 15g, Rhizoma Corydalis 15g, Semen Persicae 20g, Radix Salviae Miltiorrhizae 25g, Flos Carthami 20g, Fructus Viticis 25g, Herba Menthae 20g, Olibanum 15g, Myrrha 15g, Radix Bupleuri 15g, Rhizoma Pinelliae 25g, Rhizoma Gastrodiae 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds dextrin 50g, granulates, tabletting, makes tablet.
3, the preparation of capsule embodiment: get Herba asplenii trichomanis 25g, tetramerous jasminorange leaf 20g, Folium et cacumen Breyniae Fruticosae 28g, little Lan flower Herba Violae 25g, Radix Angelicae Dahuricae 25g, Radix Saposhnikoviae 28g, Rabdosia rubescens 15g, Rhizoma Corydalis 15g, Semen Persicae 20g, Radix Salviae Miltiorrhizae 25g, Flos Carthami 20g, Fructus Viticis 25g, Herba Menthae 20g, Olibanum 15g, Myrrha 15g, Radix Bupleuri 15g, Rhizoma Pinelliae 25g, Rhizoma Gastrodiae 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds starch 50g, granulates, fill, makes capsule.
4, pharmaceutical preparation treatment migraine of the present invention clinical research
4.1 general data: this pharmaceutical preparation is applied to clinical observation migraine case 50 example, 45 ~ 65 years old age.The shortest person of the course of disease 6 months, most elder reaches 2 years.
4.2 diagnostic criterias: ictal moderate, to severe pulsatile headache, accompanies Nausea and vomiting or photophobia.Physical exertion makes headache aggravate.Outbreak is only the light dull pain to moderate or sense of discomfort when starting, reach serious throbbing pain or jumping pain after a few minutes to several hours.About 2/3 is the headache of side property, and also can be bilatenal headache, pain is radiated to cervical region and shoulder sometimes.
4.3 test methods: prepare clinical sample by above-mentioned process for producing granula, specification is 10 grams every bag, within five days, is a course for the treatment of, one day three bags, take point early, middle and late three half an hour ante cibum.Period in a medicine is avoided eating anything raw or cold, pungent, stimulate and rotten thing.Blank group oral placebo granule five days is a course for the treatment of, one day three bags, point early, middle and late three half an hour ante cibum take.
4.4 criterions of therapeutical effect: recovery from illness: transference cure is without recurrence, and laboratory inspection is normal; Effective: transference cure, neck cranium ultrasonic examination by Doppler's method is normal, without recurrence within half a year; Effective: symptom alleviates, lab testing makes moderate progress; Invalid: symptom and lab testing are all without improvement.
4.5 therapeutic effect: in table 1.
Table 1 liang group comparitive study
| Group | n | Recovery from illness | Effective | Effectively | Invalid | Total effective rate (%) |
| Treatment group | 25 | 6 | 10 | 7 | 2 | 92 |
| Blank group | 25 | 1 | 2 | 0 | 22 | 12 |
Visible, the medicine that the present invention obtains can safe and effective treatment migraine, and has no side effect.
Claims (4)
1. one kind is used for the treatment of migrainous pharmaceutical preparation, it is characterized in that, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Herba asplenii trichomanis 25 parts, tetramerous jasminorange leaf 20 parts, Folium et cacumen Breyniae Fruticosae 28 parts, little Lan flower Herba Violae 25 parts, the Radix Angelicae Dahuricae 25 parts, Radix Saposhnikoviae 28 parts, Rabdosia rubescens 15 parts, Rhizoma Corydalis 15 parts, 20 parts, Semen Persicae, Radix Salviae Miltiorrhizae 25 parts, 20 parts, Flos Carthami, Fructus Viticis 25 parts, Herba Menthae 20 parts, Olibanum 15 parts, Myrrha 15 parts, Radix Bupleuri 15 parts, the Rhizoma Pinelliae 25 parts, 15 parts, Rhizoma Gastrodiae, 5 parts, Radix Glycyrrhizae.
2. be used for the treatment of migrainous pharmaceutical preparation as claimed in claim 1, it is characterized in that, dosage form is pharmaceutically acceptable granule, tablet, capsule.
3. be used for the treatment of migrainous pharmaceutical preparation as claimed in claim 1, it is characterized in that, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
4. be used for the treatment of the application of migrainous pharmaceutical preparation in treatment migraine remedy according to claim 1.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105663784A (en) * | 2016-01-30 | 2016-06-15 | 宋秀磊 | Traditional Chinese medicine for treating migraine |
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|---|---|---|---|---|
| CN101020004A (en) * | 2007-03-19 | 2007-08-22 | 殷彬 | Migraine treating Chinese medicine |
| CN103751570A (en) * | 2014-02-13 | 2014-04-30 | 王怀方 | Orally taken traditional Chinese medicine for treating migraine |
| CN104771625A (en) * | 2015-04-02 | 2015-07-15 | 苑丕吉 | Traditional Chinese medicine for treating migraine |
| CN104784618A (en) * | 2015-04-23 | 2015-07-22 | 淄博齐鼎立专利信息咨询有限公司 | Traditional Chinese medicine composition for treating headache |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101020004A (en) * | 2007-03-19 | 2007-08-22 | 殷彬 | Migraine treating Chinese medicine |
| CN103751570A (en) * | 2014-02-13 | 2014-04-30 | 王怀方 | Orally taken traditional Chinese medicine for treating migraine |
| CN104771625A (en) * | 2015-04-02 | 2015-07-15 | 苑丕吉 | Traditional Chinese medicine for treating migraine |
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Non-Patent Citations (1)
| Title |
|---|
| 陈绍红等: "偏头痛的用药规律探讨", 《中华中医药杂志（增刊）》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105663784A (en) * | 2016-01-30 | 2016-06-15 | 宋秀磊 | Traditional Chinese medicine for treating migraine |
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