CN1429587A - Ginkgo leaf compound preparation for improving cardiovascular and cerebrovascular blood supply - Google Patents
Ginkgo leaf compound preparation for improving cardiovascular and cerebrovascular blood supply Download PDFInfo
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- CN1429587A CN1429587A CN 01144898 CN01144898A CN1429587A CN 1429587 A CN1429587 A CN 1429587A CN 01144898 CN01144898 CN 01144898 CN 01144898 A CN01144898 A CN 01144898A CN 1429587 A CN1429587 A CN 1429587A
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Abstract
A compound preparation for reducing blood fat, improving cardiovascular and cerebrovascular blood supply and immunity, and delaying senility is prepared from ginkgo leaf 6-20g, haw 6-15g, wolfberry fruit 6-12g, acanthopanax root 9-27g, VC 30-1000 mg and VE 8-14 mg.
Description
This patent relates to the Folium Ginkgo complex, particularly prevents and treat the product of hyperlipidemia, protection cardiovascular and cerebrovascular vessel with ginkgo leaf compound preparation.
Cardiovascular and cerebrovascular disease is the principal disease of harm humans health, and its M ﹠ M has the trend that increases year by year, no matter at China or western developed country, all occupy the first place of the human cause of the death above tumor.The object of the invention is to provide a kind of product that cardiovascular and cerebrovascular disease is had good preventive effect and therapeutic effect.
The present invention is the compatibility theory according to " monarch, minister, help, make " in the science of TCM formulas, in conjunction with the latest developments of modern Chinese medicine pharmaceutical research, develops meticulously with reference to lot of documents such as " Pharmacopoeias of People's Republic of China 2000 editions ".Folium Ginkgo is a monarch drug, and Fructus Crataegi, Fructus Lycii are ministerial drug, and Radix Et Caulis Acanthopanacis Senticosi, vitamin C, vitamin E are adjuvant drug.Be referred to as medicine, mainly be according to the pharmacy principle design and have good pharmacological action because of the present invention, Fructus Crataegi, Fructus Lycii are the medicinal and edible plants that Ministry of Public Health is assert in its solid yardage, vitamin C, E are the necessary nutritional labelings of human body, Semen Ginkgo and Radix Et Caulis Acanthopanacis Senticosi also have no side effect under using method of the present invention, therefore the present invention both can be used as clinical medicine, also can be used as the composition of health product or medicated diet.Below this compound preparation is described in detail.
Folium Ginkgo is the dried leaves of Ginkgoaceae Ginkgo plant Ginkgo biloba.This tree is called as the gymnosperm living fossil for the most ancient Relict Plant in Mesozoic Era.Its main bioactive ingredients comprises flavone compound such as ginkegetin, different ginkegetin, 7-demethyl ginkegetin etc., terpene lactones chemical compound such as bilobalide, bilobalide etc., also have several amino acids, Semen Ginkgo polysaccharide, phenolic compound etc. in addition.Folium Ginkgo sweet in the mouth, hardship, puckery, property is flat, returns lung, kidney channel.The effect that the traditional Chinese medical science thinks that it has that the beneficial heart is astringed the lung, promoting blood circulation and stopping pain, Fructus Alpiniae Oxyphyllae are prolonged life.Modern pharmacology research thinks that Folium Ginkgo has following function.(1) blood fat reducing: Folium Ginkgo can reduce T-CHOL, the triglyceride of people and laboratory animal, increases high density lipoprotein; (2) improve cardiac and cerebral blood-supply: the Folium Ginkgo active component can suppress angiotensin, blood vessel dilating; But anticoagulant, antithrombotic forms; Increase erythrocyte deformability, reduce blood viscosity; Remove free radical, anti peroxidation of lipid; (3) Fructus Alpiniae Oxyphyllae is prolonged life: Folium Ginkgo extract can improve memory function, and presenile dementia is had significant curative effect, improving immunocompetence, and slow down aging, its mechanism of action is many-sided, comprises improving blood supply and metabolism, the mediator system that affects the nerves removes free radical etc.Based on above result of study, the present invention determines that Folium Ginkgo is a principal agent, gets the effect of its " blood fat reducing, improve cardiac and cerebral blood-supply, Fructus Alpiniae Oxyphyllae is prolonged life ".
Fructus Crataegi is the dry fruit of rosaceous plant Fructus Pyri Pashiae or Fructus Crataegi.Its main bioactive ingredients comprises flavone compound, comprises hyperin, Quercetin, flavone polymer etc.; Organic acid mainly contains citric acid, Crataegolic acid etc.; Also contain lactone, saccharide and glycoside etc.Fructus Crataegi sour in the mouth, sweet, slightly warm in nature is returned spleen, stomach, Liver Channel.Chinese medicine thinks that it has the effect of digestion-promoting spleen-invigorating, activating blood circulation to dissipate blood stasis.Modern pharmacology research thinks that Fructus Crataegi has following function: increase the secretion of peptic digestion enzyme, regulate gastrointestinal to the road smooth muscle; Blood pressure lowering, blood fat reducing increases myocardial contraction, arrhythmia; Remove free radical, anti peroxidation of lipid; Increase immunologic function; Functions such as diuresis is antibiotic.The present invention as " ministerial drug ", gets its advantageous effect to blood fat and heart with Fructus Crataegi, assists to increase the effect of Folium Ginkgo.
Fructus Lycii is the dry mature fruit of plant of Solanaceae lycium barbarum.Contain betanin, lycium barbarum polysaccharide, aminoacid, crude fat, crude protein, vitamin and various trace elements in the Fructus Lycii.The Fructus Lycii sweet in the mouth, property is flat.Return liver, kidney channel.Chinese medicine thinks that it has the effect of nourishing the liver and kidney, alpinia eye brightening, nourishing the lung to arrest cough.Modern pharmacology research thinks that Fructus Lycii has following function: strengthens specific immunity and nonspecific immunity, improves the repair function of dna molecular, and anti peroxidation of lipid, slow down aging, antitumor, blood fat reducing, the liver protecting strengthens hemopoietic function etc.Chinese medicine thinks that kidney governing bones store essential substances, bone marrow lead in brain, and brain foot then brain is strong and the will meaning is strong.Fructus Lycii can make eye bright because of liver nourishing, and because of the kidney tonifying Fructus Alpiniae Oxyphyllae, therefore, the present invention as " ministerial drug ", gets its blood fat reducing, Fructus Alpiniae Oxyphyllae effect such as prolong life with Fructus Lycii, increases the effect of Folium Ginkgo.
Radix Et Caulis Acanthopanacis Senticosi is the dry root and rhizome of Araliaceae Radix Et Caulis Acanthopanacis Senticosi.Contain eleutheroside A, B, C, D, E, i.e. the diglucoside of daucosterol, ligustrin, ethyl-α-D-galactoside, Syringa oblata Lindl. Meta-dihydroxybenzene (D and E, the two is isomer); Also have Radix Et Caulis Acanthopanacis Senticosi polysaccharide, chlorogenic acid, stearic acid, amygdalin, Isofraxidin, manyprickle acanthopanax general flavone etc.Radix Et Caulis Acanthopanacis Senticosi acrid in the mouth, little hardship, warm in nature, return spleen, kidney, heart channel.Effect with replenishing QI to invigorate the spleen, the kidney invigorating Fructus Alpiniae Oxyphyllae, strengthening bone and muscle, wind-damp dispelling.Modern pharmacology research thinks that Radix Et Caulis Acanthopanacis Senticosi has following function: the two-ways regulation central nervous system function, and improving memory increases immunologic function, resists myocardial ischemia, and arrhythmia is regulated three big substance metabolismes, effects such as slow down aging.The present invention with it as " adjuvant drug ".
Vitamin C is the maximum a kind of water soluble vitamins of human body requirement, and physiological function is important and complicated.Human body contains 1450mg approximately, and every day, metabolic exhaustion 1/30, needs constantly to replenish.Its major physiological function is as follows: participates in the formation of ossein, strengthens the utilization of ferrum, participate in fat and lipid metabolism, and the blood fat reducing level, antioxidation is removed free radical, and it is hemorrhage to keep little vascular toughness to prevent, and anti-stress promotes wound and burn-healing etc.Because vitamin C has above function, and compatriots' dietary habit and cooking method often cause Deficiency of Intake, and the present invention gets it as " adjuvant drug ".
Vitamin E is the nutritional labeling of needed by human, and it is a kind of Polyphenols, and very strong antioxidation is arranged.Its biological action is to suppress polyunsaturated fatty acid oxidation in the tissue film, the lipid part of stabilized cell, and the protection cell is not subjected to free radical injury; Protect erythrocytic integrity, it is synthetic to participate in DNA, is the necessary factor of Cellular respiration, can assist blood lipid regulation.Add vitamin E in the present invention, can replenish needed by human body, can prevent that again other composition is oxidized, therefore the conduct of using " adjuvant drug ".
Ginkgo leaf compound preparation of the present invention has following effect:
1. blood fat reducing: reduce T-CHOL, triglyceride in the blood, increase high density lipoprotein;
2. improve cardiac and cerebral blood-supply: suppress angiotensin, blood vessel dilating; Anticoagulant, antithrombotic forms; Increase erythrocyte deformability, reduce blood viscosity; Remove free radical, anti peroxidation of lipid;
3. raise immunity: strengthen specificity and non-specific immunity;
4. Fructus Alpiniae Oxyphyllae is prolonged life: improve memory ability, two-ways regulation nervous system, slow down aging.
The present invention can be used for prevention and treat hyperlipemia, coronary heart disease, cerebral ischemia diseases, presenile dementia etc.
The present invention can make multiple dosage forms such as tablet, capsule, granule, pill or water preparation according to the needs of using.
In order to help further fully to understand the content of this patent, be illustrated, following examples only are used to illustrate the present invention, are not to limit the invention.
Embodiment 1. compound folium ginkgo electuaries (1000 bags)
[prescription]
Folium Ginkgo 4.0kg Fructus Crataegi 3.0kg Fructus Lycii 2.0kg Radix Et Caulis Acanthopanacis Senticosi 4.0kg
Vitamin C 30g vitamin E 3g
[method for making]
1. Folium Ginkgo sorting is washed 3 times with clear water, and the drop branch that anhydrates 65～70 ℃ of bakings 3～4 hours, was pulverized 40 mesh sieves, added the water of 10 times of weights, and 100 ℃ of reflux condensation modes extracted 1 hour.Filter, filtrate is stand-by.The filtering residue second extraction adds with water gaging and continued reflux, extract, 1 hour.Filter, twice filtrate merges, and is condensed into thick paste (water content about 10～15%).
2. Radix Et Caulis Acanthopanacis Senticosi is pulverized and is placed the continuous backflow extractor, adds 7 times of amount 75% ethanol, and heating and refluxing extraction adds to extracting solution 1ml till the apparent reaction of alcoholic solution of 10% alpha-Naphthol, and concentrated extracting solution becomes extractum.
3. Fructus Crataegi, Fructus Lycii powder are broken into coarser powder, and it is standby to cross 20 mesh sieves.
4. with above-mentioned cream and powder, vitamin C, vitamin E and an amount of Icing Sugar and the abundant mixing of dextrin, system soft material, system granule, drying, granulate, packing, sterilization.
[dosage and usage] every bag of 10g is equivalent to contain Folium Ginkgo crude drug 4g.Every day 3 times, each 1 bag.
Embodiment 2. compound folium ginkgo tablets (10000)
[prescription]
Folium Ginkgo 16.0kg Fructus Crataegi 12.0kg Fructus Lycii 10.0kg Radix Et Caulis Acanthopanacis Senticosi 16.0kg
Vitamin C 100g vitamin E 15g
Starch, magnesium stearate, low-substituted hydroxypropyl cellulose are an amount of.
[method for making]
1. Folium Ginkgo was pulverized 40 mesh sieves after cleaning, and added 60% acetone 12.0kg, and in 57～59 ℃ of strong agitation centrifugal filtrations, filtrate is stand-by.Repeat above-mentioned steps and merge 2 filtrates, be evaporated to 30～40%, add 2 times of water gagings dilutions, cool off centrifugally, remove precipitation.Supernatant adds the ammonium sulfate of 30% amount, with butanone-acetone (6: 4～1: 1) liquid-liquid extraction, extract is concentrated into 50～70%, thin up to 10%, with the n-butanol extraction of half, n-butanol layer is evaporated to and contains dry 50%, distillation, gained water liquid concentrating under reduced pressure drying obtains the about 400g of extract.
2. Fructus Crataegi is pulverized, and with 95% alcohol reflux 3 times, filtered while hot, merging backflow, decompression recycling ethanol also is condensed into the thick paste shape.
3. Fructus Lycii is pulverized, and uses water extraction, adds 6 times of water gagings for the first time, decocts 2 hours, adds 4 times of water gagings for the second time, decocts 1 hour, adds 2 times of water gagings for the third time, decocts 45 minutes, merges 3 times filtrate, crosses 200 mesh sieves, and evaporation and concentration is to the thick paste shape.
4. Radix Et Caulis Acanthopanacis Senticosi is pulverized, and adds 6 times of water gagings, decocts 3 hours, gets filtrate, and residue is added 6 times of water gagings, decocts 2 hours, merges 2 times filtrate, is condensed into 30% clear paste; Add 3 times of amount ethanol, left standstill 6 hours, get supernatant and filter, residue adds 3 times of amount ethanol again, leaves standstill, and gets supernatant and filters, and merges decompression filtrate recycling ethanol twice, is condensed into the thick paste shape.
5. merging 1. 2. 3. 4. gained thick paste, add vitamin C, vitamin E, add appropriate amount of starch, the abundant mixing of low-substituted hydroxypropyl cellulose, is wetting agent with 60% ethanol, and the back of granulating adds 30g magnesium stearate, tabletting behind the mixing, coating.
[dosage and usage] every heavy 0.3g contains the Folium Ginkgo composition and is equivalent to crude drug 1.6g, contains the about 8～10mg of Semen Ginkgo total flavones.Every day 3 times, each 2.
Embodiment 3. compound folium ginkgo capsules (10000)
[prescription]
Folium Ginkgo 16.0kg Fructus Crataegi 12.0kg Fructus Lycii 10.0kg Radix Et Caulis Acanthopanacis Senticosi 16.0kg
Vitamin C 100g vitamin E 15g starch is an amount of.
[method for making]
1. Folium Ginkgo, Fructus Crataegi, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi thick paste method for making are with embodiment 2.
2. with each thick paste, vitamin C, vitamin E, add the abundant mixing of appropriate amount of starch, pulverized 80 mesh sieves, the glue of packing into
Capsule, sterilization.
The heavy 0.4g of [dosage and usage] every capsules contains the Folium Ginkgo composition and is equivalent to crude drug 1.6g, contains the about 8～10mg of Semen Ginkgo total flavones.Every day 3 times, each 2.
Embodiment 4. compound gingko leaf preparations are to the influence of rat fat level
Get 40 of Wistar rats, male and female half and half, body weight 200 ± 20g is divided into four groups at random.The I group is the normal control group, and the II group is the hyperlipemia group, and the III group is low concentration gingko leaf preparation group, and the IV group is high concentration gingko leaf preparation group.The I group gives normal diet, and the II group gives high fat diet, and III group, IV group are irritated stomach with compound folium ginkgo electuary 5g/kg among the embodiment 1 and 10g/kg respectively when giving high fat diet, in continuous 4 weeks, gets blood examination and surveys T-CHOL (TC), triglyceride (TG).The result is as shown in table 1, and high fat diet group blood lipid level illustrates the modelling success apparently higher than matched group (P＜0.01), and the compound folium ginkgo electuary can significantly reduce the T-CHOL and the triglyceride level of hyperlipidemia rats, and dose-effect relationship is arranged.
Table 1. compound folium ginkgo electuary is to the influence of rat fat level
Group size of animal (n) TC (mg/d1) TG (mg/d1)
I organizes 10 88.1 ± 3.1
*44.2 ± 7.5
*
II organizes 10 498.2 ± 99.6 105 ± 12.6
III organizes 10 298.3 ± 45.7
*58.8 ± 4.3
*
IV organizes 10 184.5 ± 19.4
*48.3 ± 8.4
*
*Compare with the II group P＜0.01
Embodiment 5. compound gingko leaf preparations are to the influence of platelet aggregation and fiber protein content
20 of white rabbits are planted by New Zealand, and male and female are regardless of, and are divided into 2 groups at random, matched group and gingko leaf preparation group.Matched group is given normal diet, and the Folium Ginkgo group is added the preparation 1g/kg among the embodiment 3 in feedstuff, feeds 7 days.Be rich in hematoblastic blood plasma in the forward and backward blood sampling respectively of medication preparation, assemble,, measure fibrinogen content with the Desvignes method with turbidimetry for Determination platelet aggregation degree with the ADP induced platelet.The result is as shown in table 2, but the Folium Ginkgo capsule anticoagulant reduces fibrinogen content, points out it to have the effect that suppresses thrombosis and then improve the blood vessel blood supply.
Table 2. compound folium ginkgo capsule is to the influence of platelet aggregation and fibrinogen level
Group size of animal platelet aggregation degree suppression ratio fiber protein content
(n) behind the medicine prodrug behind (%) medicine prodrug
Matched group 10 43 ± 10 41 ± 12 480 ± 78 468 ± 69
Folium Ginkgo group 10 35 ± 6 28 ± 9
*25 509 ± 183 436 ± 167
* *P＜0.01 is relatively preceding with medication
Embodiment 6. compound gingko leaf preparations are to the amnemonic influence of Anisodine induced mice
Adopt the mice diving tower method check memory function of improving of the present invention.40 of kunming mouses, male and female half and half, body weight 32 ± 2g is divided into four groups at random.The I group is the normal control group, and the II group is the Anisodine group, and the III group is low concentration gingko leaf preparation group, and the IV group is high concentration gingko leaf preparation group.Compound folium ginkgo electuary 5g/kg and 10g/kg that III group, IV group give among the embodiment 1 irritate stomach, and I group, II group give equivalent normal saline, logotype 3 days.After the last administration 20 minutes, II group, III group, IV organized in lumbar injection Anisodine 10mg/kg, and the I group gives the equivalent normal saline, trained test memory achievement after 24 hours.The result is as shown in table 3, illustrates that compound gingko leaf preparation has the function of improving memory preferably.
Table 3. compound folium ginkgo electuary is to the amnemonic influence of Anisodine induced mice
Group size of animal (n) training period mistake is counted test period mistake number
I organizes 10 3.6 ± 0.6 1.2 ± 0.2
II organizes 10 6.0 ± 2.1 3.4 ± 0.4
III organizes 10 2.7 ± 0.6
*1.7 ± 0.3
*
IV organizes 10 2.1 ± 0.7
*1.3 ± 0.2
*
*Compare with the II group P＜0.01
Embodiment 7. compound gingko leaf preparations are to the influence of mouse aging main organs lipofuscin
Make the mouse aging model with the D-galactose.40 of kunming mouses, male and female half and half, body weight 32 ± 2g is divided into four groups at random.The I group is the normal control group, and the II group is model group, and the III group is low concentration gingko leaf preparation group, and the IV group is high concentration gingko leaf preparation group.Compound folium ginkgo electuary 5g/kg and 10g/kg that III group, IV group give among the embodiment 1 irritate stomach, and I group, II group give the equivalent normal saline, and after the administration 45 minutes, except that the I group, other three groups in retrobulbar injection D-galactose 80mg/kg, logotype 50 days.Execution is cored, liver, brain.Detect every gram tissue by the Sohal method and contain the lipofuscin units, the result is as shown in table 4, the old and feeble group of D-galactose mice lipofuscin concentration significantly increases (P＜0.01), the modelling success is described, give compound gingko leaf preparation simultaneously and can reduce lipofuscin content, significant difference points out it to have anti-aging effects.
Table 4. compound folium ginkgo electuary is to the influence of the mouse aging heart, liver, brain lipofuscin content
Group size of animal heart lipofuscin liver lipofuscin brain lipofuscin
(n) (u/g) (u/g) (u/g)
I organizes 10 0.17 ± 0.025
*0.049 ± 0.012
*0.23 ± 0.022
*
II organizes 10 0.24 ± 0.085 0.076 ± 0.041 0.25 ± 0.053
III organizes 10 0.17 ± 0.015
*0.048 ± 0.009
*0.19 ± 0.011
*
IV organizes 10 0.18 ± 0.013
*0.052 ± 0.021
*0.23 ± 0.027
*
*Compare with the II group P＜0.01
Claims (6)
1. one kind has the ginkgo leaf compound preparation that protects the effect of heart benefit brain, and its feature is containing Folium Ginkgo 6～20g, Fructus Crataegi 6～15g, Fructus Lycii 6～12g, Radix Et Caulis Acanthopanacis Senticosi 9～27g, vitamin C 50～1000mg, vitamin E 8～14mg;
2. according to right 1, the Folium Ginkgo component can be a crude drug, also can be the extract of Folium Ginkgo or the effective component of ginkgo leaf of synthetic;
3. according to right 1, Fructus Crataegi, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi can be crude drugs, also can be water extract or alcohol extract;
4. according to right 1, this compound preparation can add one or more of diluent commonly used in the pharmaceutical manufacturing, wetting agent, binding agent, disintegrating agent, lubricant, coloring agent, aromatic, correctives, antibacterial antiseptic;
5. according to right 1, this compound preparation both can be the component of health product, medicated diet, also can be the medicine of clinical practice;
6. according to right 1, this compound preparation can be tablet, capsule, granule, pill or water preparation.
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| CN 01144898 CN1429587A (en) | 2001-12-30 | 2001-12-30 | Ginkgo leaf compound preparation for improving cardiovascular and cerebrovascular blood supply |
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| CN 01144898 CN1429587A (en) | 2001-12-30 | 2001-12-30 | Ginkgo leaf compound preparation for improving cardiovascular and cerebrovascular blood supply |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103893293A (en) * | 2014-04-10 | 2014-07-02 | 中国人民解放军空军航空医学研究所 | Compound folium ginkgo preparation for improving learning and memory abilities |
| CN104082374A (en) * | 2014-07-04 | 2014-10-08 | 贵州黄平靓鸥桑综合开发有限公司 | Biscuits capable of reducing blood fat |
| CN107242353A (en) * | 2016-07-27 | 2017-10-13 | 江西中成人药业有限公司 | Stress crude granule and preparation method thereof |
-
2001
- 2001-12-30 CN CN 01144898 patent/CN1429587A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103893293A (en) * | 2014-04-10 | 2014-07-02 | 中国人民解放军空军航空医学研究所 | Compound folium ginkgo preparation for improving learning and memory abilities |
| CN103893293B (en) * | 2014-04-10 | 2016-06-15 | 中国人民解放军空军航空医学研究所 | A kind of compound gingko leaf preparation improving learning and memory function |
| CN104082374A (en) * | 2014-07-04 | 2014-10-08 | 贵州黄平靓鸥桑综合开发有限公司 | Biscuits capable of reducing blood fat |
| CN107242353A (en) * | 2016-07-27 | 2017-10-13 | 江西中成人药业有限公司 | Stress crude granule and preparation method thereof |
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