CN1159029C - Blood lipoid regulating medicine and its prepn - Google Patents
Blood lipoid regulating medicine and its prepn Download PDFInfo
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- CN1159029C CN1159029C CNB001351850A CN00135185A CN1159029C CN 1159029 C CN1159029 C CN 1159029C CN B001351850 A CNB001351850 A CN B001351850A CN 00135185 A CN00135185 A CN 00135185A CN 1159029 C CN1159029 C CN 1159029C
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Abstract
The present invention relates to a blood fat regulating medicine and a preparation method thereof. The blood fat regulating medicine is prepared into capsules and from raw materials of the following proportion by weight: 60 to 90 of folium cortex eucommiae, 10 to 20 of green tea, 6 to 10 of kudzuvine root, 3 to 7 of ginkgo leaf, 3 to 7 of haw, 3 to 7 of barbary wolfberry fruit and 0.5 to 2 of tall gastrodia tuber. Compared with the prior art, the method of the present invention is characterized in that 1. cortex eucommiae is replaced with folium cortex eucommiae which is used as crude medicines; 2. an extra-high pressure homogenizer in 70MPa is used for the homogenization of liquid medicines to cause the liquid medicines to be emulsified sufficiently. Consequently, the blood fat regulating medicine is easily absorbed by human bodies. The blood fat regulating medicine of the present invention shortens the obvious effect period of the medicines and enhances the curative effects of the medicines.
Description
The present invention relates to a kind of lipid-regulation medicine and preparation method thereof, relate in particular to a kind of lipid-regulation medicine that forms with prepared from traditional Chinese medicines and preparation method thereof.
Cardiovascular and cerebrovascular disease is the disease of a class serious harm human health.In recent years, progress and the raising day by day of living standards of the people and the continuous quickening of work rhythm along with society, no matter in western countries or oriental countries, the M ﹠ M of cardiovascular and cerebrovascular disease all is obvious rising situation, and becomes the No.1 killer of human health gradually.Continuous development along with medical science, people recognize that cholesterol, fat etc. are the basic causes of disease that cardiovascular and cerebrovascular disease takes place, and hyperlipidemia (showing as degradation under cholesterol, triglyceride and low density lipoprotein, LDL rising, the high density lipoprotein) is that coronary heart disease and hypertensive main hazard factor take place.Therefore, grab the research and development of blood lipid regulation technology countries in the world as the emphasis of the human cardiovascular and cerebrovascular disease of control.
According to the literature, have both at home and abroad multiple in, Western medicine is used for the treatment of hyperlipidemia, as domestic, in " Chinese Chinese medicine and western medicine combination " 1994,14 (1), P41～42 have been reported and have been entitled as " effect for reducing fat of Mulberry Pueraria lobota fat reducing pill and hypogastric lipid-lowering pill is observed ", mention in the literary composition that Mulberry Pueraria lobota fat reducing pill is by Herba Taxilli, Radix Puerariae, Radix Salviae Miltiorrhizae, Fructus Crataegi, Rhizoma Alismatis, Artemisia anethoicles Mattf, Chinese medicines such as Flos Carthami are formed, 324 routine patients take Mulberry Pueraria lobota fat reducing pill, after 1 course of treatment (30 days), its TC (cholesterol) on average descends 19.7%, and TG (triglyceride) on average descends 15.7%, and HDL-C (high density lipoprotein) rises 9%.In " combination of Chinese and Western medicine " 1990,10 (1), P22～24 have been reported with Chinese medicine and have been transferred fat soup with card plus-minus treatment hyperlipidemia, mention in the literary composition that the basic composition of this accent fat soup is made up of Radix Glycyrrhizae, Fructus Lycii, Radix Bupleuri, Rhizoma Alismatis, Fructus Crataegi, Radix Salviae Miltiorrhizae, Flos Carthami etc., 34 routine patients took medicine after 4 weeks, and TC on average descends 15%, and TC descends 38%, LDL-C descends 15%, and HDL-C increases by 28%.At " Heilungkiang Chinese medicine " 1997,2, P49 has reported and has taken compound haw thorn decoct (being made up of Fructus Crataegi, Radix Salviae Miltiorrhizae, Radix Puerariae) treatment high fat of blood 30 examples that through treatment 1 course of treatment (30 days), TC descends 17%, TG decline 46%, HDL rising 25%.In " hypertension " 1996,4 (2), P110～112 have reported and have been entitled as " tea polyphenols is to the influence of rat experiment hyperlipidemia " article that 50 rats that the author will feed high lipid food according to blood lipid level are divided into 5 groups at random, i.e. TPD heavy dose (TP
H) group, dosage (TP among the TP
H) group, TP low dose (TP
L) group, nicotinic acid group and hyperlipidemia matched group, experimental result, tea polyphenols (TP) has serum TC, TG and the LDL-C effect of reduction, when the oral TP135mg/kg of hyperlipemia rat (15 days), its effect for reducing blood fat is stronger than Western medicine nicotinic acid 30mg/kg, TP45mg/kg and nicotinic acid are similar, and TP is strong than other lipid composition to TG reduction effect.At " Chinese new drug " 1997,6 (5), P357～359 have reported that reach (Western medicine) of taking fat regulation medicine Lip rivers such as homemade his spit of fland control 34 routine hyperlipemias, through the treatment of 8 weeks, its TC descends 19.5%, and TG descends 14.5%, LDL-C descends 26.8%, and HDL-C rises 6.7%.
Abroad, with traditional Chinese medicine, Chinese herbal medicine, the bibliographical information of Chinese patent drugs for treatment hyperlipidemia is very few, the Japan Nagoya City Wu of university etc. are at " Biol.Pharm.Bull " 1998,21 (12), traditional Chinese herbal medicine (Ogi-Keishi-Gomotsu-To-Ka-Kojin (also claiming Chinese prescription Chinese medicine) has been reported in P1311～1316, research to the cholesterol metabolism influence, mention in the literary composition that the abundant diet of cholesterol has suppressed cholesterol-7-α-hydroxylase activity, inhibition is active to reverse and this liquid side's Chinese medicine makes, through experiment confirm, the abundant Mus of feeding cholesterol is 4 weeks of Chinese prescription treatment by Chinese herbs of 1.38g/kg through dosage, then the total cholesterol level of Mus significantly reduces, the author thinks can become effective smelting treatment agent of hypercholesterolemia patient by this Chinese prescription Chinese medicine.The Hong Kong Yang of university etc. are at " Life Sci. " 2000,66 (5), p411-423 has reported the activity research of three main lipid metabolism enzymes and mensuration, the author thinks that green tea does not influence the vigor of above-mentioned three kinds of enzymes, but take the crowd of green tea through 8 week, its serum cholesterol significantly reduces, and the author thinks that Chinese green tea is to come the cholesterol reducing level by the drainage that increases the drainage of feces fat, feces cholic acid and cholesterol.Sweden Clinical Research Center Kenzelmann etc. are at " Arzneimittelforschung " 1993,43 (9), P978～981 have reported that suppressing lipid parameter by Bulbus Allii-ginkgo agent worsens, through Bulbus Allii-ginkgo agent treatment, T-CHOL is reduced to 293 ± 56mg/dl from 298.6 ± 44.4mg/dl after 1 month, T-CHOL reduction by 10.4% after February (267.6 ± 44.4mg/dl), studies show that the Bulbus Allii treatment is effectively, but need to continue long-term treatment.
Though above-mentioned existing lipid-regulation medicine all has certain effect to blood fat reducing, still there is defective separately, taken untoward reaction for a long time such as Western medicine, and that Chinese medicine takes effect is slower after taking, curative effect is remarkable inadequately, and decoction particularly carries, keeping inconvenience.
Purpose of the present invention be exactly provide in order to overcome the defective that above-mentioned prior art exists a kind of improve human body to the absorbtivity of medicine, shorten medicine take effect phase, lipid-regulation medicine evident in efficacy, easy to carry and preparation method thereof.
Purpose of the present invention can be achieved through the following technical solutions:
A kind of lipid-regulation medicine is characterized in, it comprises the capsule that the following weight proportion raw material is made:
Folium Eucommiae 60～90
Green tea 10～20
Radix Puerariae 6～10
Folium Ginkgo 3～7
Fructus Crataegi 3～7
Fructus Lycii 3～7
Rhizoma Gastrodiae 0.5～2
The preferred weight proportioning of described each raw material is:
Folium Eucommiae 80～90
Green tea 10～15
Radix Puerariae 7～9
Folium Ginkgo 4～6
Fructus Crataegi 4～6
Fructus Lycii 4～6
Rhizoma Gastrodiae 1～2
The optimum weight proportioning of described each raw material is:
Folium Eucommiae 90
Green tea 10
Radix Puerariae 6
Folium Ginkgo 3
Fructus Crataegi 3
Fructus Lycii 3
Rhizoma Gastrodiae 1.5
A kind of preparation method of above-mentioned lipid-regulation medicine is characterized in, it comprises following processing step:
The first step is got Folium Eucommiae, green tea, and the weight proportion by 60～90: 10～20 carry out drying and crushing to 80 respectively～100 orders, obtains the crude drug in whole fine powder, then both is mixed and add the boiling granulating machine;
Second step, get Radix Puerariae, Folium Ginkgo, Fructus Crataegi, Fructus Lycii, Rhizoma Gastrodiae by 6～10: 3～7: 3～7: 3～7: 0.5～2 weight proportion is put into pot, the water boil of 15～25 times of weight of adding 1～3 hour, separate then and remove slag, filtration makes filtrate, with this filtrate homogenizing in the homogenizer of supertension 50～70MPa, concentrate at last and obtain medicinal liquid;
The 3rd step, get dextrin and add the water stirring, make dextrin solution;
The 4th step sprayed into second step, the 3rd medicinal liquid that make respectively of step and solution on the fine powder that the first step makes, and in the boiling granulating machine drying and granulating, make the lipid-regulation medicine granule;
In the 5th step, the drug particles that the 4th step was obtained pours into capsule, packs then, obtains the lipid-regulation medicine product.
Compared with prior art, the lipid-regulation medicine that adopts the inventive method to make has significant curative effect at aspects such as anti-curing hyperlipemia, cardiovascular and cerebrovascular disease, removing blood vessel rubbish.The Chinese People's Liberation Army has carried out clinic study to product of the present invention in the clinical nutrition center, and research report is as follows:
Object of study: be diagnosed as hyperlipidemia patient totally 31 examples, 55.8 ± 8.9 years old mean age in outpatient service.Wherein simple property hypercholesterolemia (IIa example) 11 examples, combined hyperlipidemia (IIb type) 12 examples, simple property hypertriglyceridemia (IV type) 8 examples.The sugar crusty pancake that does not comprise controlling symptoms is sick, thyroid function is not normal, pancreatitis or other influence lipometabolic disease, liver, renal insufficiency and suffer from other serious disease patients.
Research method: every of blood fat reducing recovering capsule contains blood fat reducing health 170mg.Taking dose is each 3, takes medicine every day 3 times, observes the therapeutic effect after 4 weeks of taking medicine.Do not establish matched group, compare as own control before and after the patient takes medicine.Measure 2 fasting plasma lipids before taking medicine, comprise TC, TG, HDL-C and LDL-C, the 2nd fasting plasma lipid is as basic blood lipid level.
The hyperlipemia disease diagnosis basis
IIa type TC＞5.95mmol/L (230mg/dl), TG (2.26mmol/L (200mg/dl);
IIb type TC＞5.95mmol/L (230mg/dl), TG＞2.26mmol/L (200mg/dl);
IV type TC＜5.95mmol/L (230mg/dl), TG＞2.26mmol/L (200mg/dl).
The result: the Blood Lipid of taking blood fat reducing health 4 week back 31 routine patients see Table 1. from table the result as seen, the blood fat reducing health can reduce patients serum TC level significantly, average 13.7% (P＜0.05) that reduces, 4 week of treatment back and is compared before the treatment, different significantly.Serum TG on average reduces by 40.0% (P＜0.01), with the treatment before compare, the difference of highly significant is arranged.Serum HDL-G on average rises 12% after taking the blood fat reducing health, and LDL-C on average descends 13%.Serum TC and TG level be every day after using 4 weeks of 1500mg blood fat reducing health, and natural rate of interest is respectively 48.4% and 54.8%, with the treatment before compare difference highly significant (P＜0.01 and P＜0.05).Take medicine before and after look patient's hepatic and renal function, the result is normally.
Table 1 is taken the comparison that changes of back blood lipid levels of blood fat reducing health 4 week (mmol/L, x ± s)
| Inspection item | All numbers of taking medicine | The IIa type | The IIb type | The IV type |
| TC | 0 | 6.89±0.69 | 6.74±0.72 | 4.98±0.85 |
| 4 | 5.78±0.91(16↓) * | 5.69±0.64(16↓) * | 4.54±0.79(9↓) | |
| TG | 0 | 1.81±1.02 | 4.23±0.97 | 4.51±1.24 |
| 4 | 1.24±0.98(31↓) ** | 2.41±0.88(43↓) ** | 2.45±1.10(46↓) ** | |
| HDL-C | 0 | 1.41±0.54 | 1.38±0.91 | 1.15±0.67 |
| 4 | 1.53±0.87(9↑) | 1.49±0.89(8↑) | 1.37±0.94(19↑) * | |
| LDL-C | 0 | 4.28±1.24 | 3.87±1.01 | 2.28±0.69 |
| 4 | 3.61±0.57(16↓) * | 3.21±0.98(17↓) * | 2.14±0.92(6↓) |
Annotate: the numeral in the bracket is blood fat rising (↑) or reduces the percent of (↓); Compare * P＜0.05, * * P＜0.01 with (0 week) before the treatment
Conclusion: this result of study shows that the blood fat reducing health has the effect that reduces TC, TG, does not see harmful effect to other organ functions of body.
In addition, the Chinese People's Liberation Army has also carried out animal experiment and toxicity test to product of the present invention in the clinical nutrition center, and zooperal evaluation is: each dosage group of product of the present invention all has tangible reduction effect to experimental hyperlipemia in rats.The evaluation of toxicity test is: according to oral administration route, with reference to each relevant evaluation criterion, result of the test shows product of the present invention to the laboratory animal free of toxic effects, and LD50＞5g/kg belongs to basic non-toxic compound.
The characteristics of the inventive method are one, exist with the Folium Eucommiae replacement Cortex Eucommiae and as crude drug in whole; Two, adopt supertension 70MPa homogenizer that medicinal liquid is carried out homogenizing and handle, make medicinal liquid fully emulsified, thereby make the easier absorption of human body, shortened taking effect the phase of medicine, improved the curative effect of medicine.
Below in conjunction with specific embodiment, the invention will be further described.
Embodiment 1
Take by weighing raw material (kilogram) by following proportioning:
Folium Eucommiae 90, green tea 10, Radix Puerariae 6, Folium Ginkgo 3, Fructus Crataegi 3, Fructus Lycii 3, Rhizoma Gastrodiae 1.5, dextrin 16.
Preparation method comprises following processing step:
The first step by said ratio, is got Folium Eucommiae respectively, green tea carries out drying and crushing to 80 order, then both is mixed and add the boiling granulating machine;
In second step,, respectively Radix Puerariae, Folium Ginkgo, Fructus Crataegi, Fructus Lycii, Rhizoma Gastrodiae are put into pot by said ratio, the water boil of 20 times of weight of adding 2 hours separates then and removes slag, and filters to get filtrate, with this filtrate homogenizing in the homogenizer of supertension 70MPa, concentrate at last and make medicinal liquid again;
The 3rd step, by said ratio, get dextrin and add water and stir, make dextrin solution;
The 4th step sprayed into second step, the 3rd medicinal liquid, the solution that make respectively of step on the fine powder that the first step makes, and in the boiling granulating machine drying and granulating, make the lipid-regulation medicine granule;
In the 5th step, the drug particles that the 4th step was obtained pours into capsule, packs then, promptly makes the lipid-regulation medicine product.
Embodiment 2
Take by weighing raw material (kilogram) by following proportioning:
Folium Eucommiae 80, green tea 15, Radix Puerariae 8, Folium Ginkgo 5, Fructus Crataegi 5, Fructus Lycii 5, Rhizoma Gastrodiae 1.5, dextrin 16.
Preparation method comprises following processing step:
The first step by said ratio, is got Folium Eucommiae respectively, green tea carries out drying and crushing to 100 order, then both is mixed and add the boiling granulating machine;
In second step,, respectively Radix Puerariae, Folium Ginkgo, Fructus Crataegi, Fructus Lycii, Rhizoma Gastrodiae are put into pot by said ratio, the water boil of 25 times of weight of adding 3 hours separates then and removes slag, and filters to get filtrate, with this filtrate homogenizing in the homogenizer of supertension 70MPa, concentrate at last and make medicinal liquid again;
The 3rd step, by said ratio, get dextrin and add water and stir, make dextrin solution;
The 4th step sprayed into second step, the 3rd medicinal liquid, the solution that make respectively of step on the fine powder that the first step makes, and in the boiling granulating machine drying and granulating, make the lipid-regulation medicine granule;
In the 5th step, the drug particles that the 4th step was obtained pours into capsule, packs then, promptly makes the lipid-regulation medicine product.
Embodiment 3
Take by weighing raw material (kilogram) by following proportioning:
Folium Eucommiae 60, green tea 20, Radix Puerariae 10, Folium Ginkgo 7, Fructus Crataegi 7, Fructus Lycii 7, Rhizoma Gastrodiae 2, dextrin 16.
Preparation method comprises following processing step:
The first step by said ratio, is got Folium Eucommiae respectively, green tea carries out drying and crushing to 80 order, then both is mixed and add the boiling granulating machine;
In second step,, respectively Radix Puerariae, Folium Ginkgo, Fructus Crataegi, Fructus Lycii, Rhizoma Gastrodiae are put into pot by said ratio, the water boil of 15 times of weight of adding 1 hour separates then and removes slag, and filters to get filtrate, with this filtrate homogenizing in the homogenizer of supertension 70MPa, concentrate at last and make medicinal liquid again;
The 3rd step, by said ratio, get dextrin and add water and stir, make dextrin solution;
The 4th step sprayed into second step, the 3rd medicinal liquid, the solution that make respectively of step on the fine powder that the first step makes, and in the boiling granulating machine drying and granulating, make the lipid-regulation medicine granule;
In the 5th step, the drug particles that the 4th step was obtained pours into capsule, packs then, promptly makes the lipid-regulation medicine product.
Claims (4)
1. a lipid-regulation medicine is characterized in that, it is the capsule of being made by the following weight proportion raw material:
Folium Eucommiae 60～90
Green tea 10～20
Radix Puerariae 6～10
Folium Ginkgo 3～7
Fructus Crataegi 3～7
Fructus Lycii 3～7
Rhizoma Gastrodiae 0.5～2.
2. lipid-regulation medicine according to claim 1 is characterized in that, the weight proportion of each raw material is:
Folium Eucommiae 80～90
Green tea 10～15
Radix Puerariae 7～9
Folium Ginkgo 4～6
Fructus Crataegi 4～6
Fructus Lycii 4～6
Rhizoma Gastrodiae 1～2.
3. lipid-regulation medicine according to claim 1 is characterized in that, the weight proportion of each raw material is:
Folium Eucommiae 90
Green tea 10
Radix Puerariae 6
Folium Ginkgo 3
Fructus Crataegi 3
Fructus Lycii 3
Rhizoma Gastrodiae 1.5.
4. the preparation method of the described a kind of lipid-regulation medicine of claim 1 is characterized in that, it comprises following processing step:
The first step is got Folium Eucommiae, green tea, and the weight proportion by 60～90: 10～20 carry out drying and crushing to 80 respectively～100 orders, obtains the crude drug in whole fine powder, then both is mixed and add the boiling granulating machine;
Second step, get Radix Puerariae, Folium Ginkgo, Fructus Crataegi, Fructus Lycii, Rhizoma Gastrodiae by 6～10: 3～7: 3～7: 3～7: 0.5～2 weight proportion is put into pot, the water boil of 15～25 times of weight of adding 1～3 hour, separate then and remove slag, filtration makes filtrate, with this filtrate homogenizing in the homogenizer of supertension 50～70MPa, concentrate at last and obtain medicinal liquid;
The 3rd step, get dextrin and add the water stirring, make dextrin solution;
The 4th step sprayed into second step, the 3rd medicinal liquid that make respectively of step and solution on the fine powder that the first step makes, and in the boiling granulating machine drying and granulating, make the lipid-regulation medicine granule;
In the 5th step, the drug particles that the 4th step was obtained pours into capsule, packs then, obtains the lipid-regulation medicine product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB001351850A CN1159029C (en) | 2000-12-26 | 2000-12-26 | Blood lipoid regulating medicine and its prepn |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB001351850A CN1159029C (en) | 2000-12-26 | 2000-12-26 | Blood lipoid regulating medicine and its prepn |
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| Publication Number | Publication Date |
|---|---|
| CN1360902A CN1360902A (en) | 2002-07-31 |
| CN1159029C true CN1159029C (en) | 2004-07-28 |
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| CNB001351850A Expired - Fee Related CN1159029C (en) | 2000-12-26 | 2000-12-26 | Blood lipoid regulating medicine and its prepn |
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Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101467575B (en) * | 2007-10-13 | 2012-09-05 | 朱青 | Hypoglycemic fat-regulating health-care nutrient tea and method for producing the same |
| CN101803646B (en) * | 2010-01-15 | 2013-05-01 | 王德荣 | Fat-reducing health protecting tea and preparation method thereof |
| CN101773176A (en) * | 2010-01-15 | 2010-07-14 | 王德荣 | Antihypertensive healthful tea and preparation method thereof |
| CN102626452A (en) * | 2012-04-25 | 2012-08-08 | 吴庆林 | Hawthorn, radix puerariae, gingko and balsam pear four-in-one flavone capsule |
| CN108144034A (en) * | 2018-02-13 | 2018-06-12 | 桂林三金大健康产业有限公司 | A kind of reducing blood lipid and/or Chinese medicine composition and its application for improving memory |
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