CN1823943A - Preparation technology of Chinese medicine naodesheng concentrate pill - Google Patents
Preparation technology of Chinese medicine naodesheng concentrate pill Download PDFInfo
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- CN1823943A CN1823943A CN 200510032582 CN200510032582A CN1823943A CN 1823943 A CN1823943 A CN 1823943A CN 200510032582 CN200510032582 CN 200510032582 CN 200510032582 A CN200510032582 A CN 200510032582A CN 1823943 A CN1823943 A CN 1823943A
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- naodesheng
- chinese medicine
- radix puerariae
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Abstract
A process for preparing the Chinese medicine Naodesheng in the form of concentrated pills from notoginseng, Chuan-xiong rhizome, safflower, pueraria root and haw without kernel includes such steps as pulverizing notoginseng and part of pueraria root to obtain fine powder, decocting others twice, collecting decoction, filtering, concentrating, adding said fine powder, honeying, mixing, pilling, coating and drying.
Description
Technical field
The present invention relates to a kind of preparation technology of Chinese medicine naodesheng concentrate pill.
Background technology
At present, be used for the treatment of cerebral arteriosclerosis, the Chinese medicine of ischemia apoplexy and apoplexy sequela mainly contains NAODESHENG, and blood circulation promoting and blood stasis dispelling is arranged, dredging the meridian, the effect of consciousness-restoring and orifice-opening.Number of patent application is 200410065797.X, and 200410014158.0 preparation methoies of describing a kind of soft capsule Naodesheng respectively, all is to adopt ethanol to extract, its complex process, and cost is higher.In addition, common honeyed pill is just pulverized raw medicinal herbs in preparation process simply, sieve, and mixing, preparation process is too simple, and is coarse, and unfavorable effective ingredient is absorbed fully by human body.
Summary of the invention
Purpose of the present invention aims to provide a kind of biological utilization rate that improves, and preparation technology is simple, and technology is more perfect, applicable to the preparation technology of the Chinese medicine naodesheng concentrate pill of industrialized great production.
The objective of the invention is to realize by following manner:
Raw material of the present invention is: the Fructus Crataegi 157g of Radix Notoginseng 78g, Rhizoma Chuanxiong 78g, Flos Carthami 91g, Radix Puerariae 261g, enucleation, get Radix Notoginseng 78g, Radix Puerariae 130.5g pulverize separately becomes fine powder, all the other Flos Carthamis, Rhizoma Chuanxiong, Fructus Crataegi and rest radix puerariae decoct with water secondary, add for the first time 10 times of water gagings 1.5 hours, add for the second time 8 times of water gagings 1 hour, collecting decoction, filter, filtrate is concentrated into the clear paste that relative density is 1.22-1.25 (80 ℃ of survey), adds Radix Puerariae fine powder, Radix Notoginseng fine powder, 50g refined honey, mixing, pill is put the coating pan internal rotation, coating, drying, promptly.
Described drying is 75 ℃ of following dryings 4 hours,
In the coating process, every 100g pill adds the active carbon of 0.5g.
Before Radix Notoginseng, Radix Puerariae are pulverized, Radix Notoginseng, Radix Puerariae are removed impurity, clean, placed 55-65 ℃ of drying about 6 hours, make water content surpass 5%.
Get Radix Notoginseng, Radix Puerariae pulverizing, cross 80 mesh sieves, become fine powder.
Amount of water, extraction time, extraction time are the key factors that influences extraction effect among the present invention.The inventor has obtained an optimal scheme of the present invention by following experiment.
The experiment of Flos Carthami, Rhizoma Chuanxiong, Fructus Crataegi and residue Radix Puerariae extraction process by water condition
Therefore, serve as to investigate index with puerarin extracted amount and dry extract yield, select orthogonal table L
9(3
4) carrying out orthogonal test, experimental procedure and result are as follows:
1.1, water proposes the investigation of number of times
Take by weighing Rhizoma Chuanxiong 15.6g, Flos Carthami 18.2g, Radix Puerariae 26.1g, Fructus Crataegi (enucleation) 31.4g (91.3g altogether) of 1/5 recipe quantity in the prescription ratio, decoct with water three times (10 times, 1.5 hours; 8 times, 1 hour; 6 times, 0.5 hour), filtering, first and second time is concentrated, dry respectively with water extract for the third time, measures this two-part dry extract extraction ratio, the results are shown in Table 1.
Table 1 water is proposed the examination of number of times
Last table result shows, Rhizoma Chuanxiong, Flos Carthami, Radix Puerariae, Fructus Crataegi (enucleation) four flavor extracting in water secondaries, and its dry extract extraction ratio is 91.69%, extraction ratio only accounts for 8.31% for the third time, so extraction process by water adopts secondary to get final product, and is consistent with former tablet technology.
1.2 water extraction condition examination
Get Rhizoma Chuanxiong 15.6g, Flos Carthami 18.2g, Radix Puerariae 26.1g, Fructus Crataegi (enucleation) 31.4g (91.3g altogether), with add water doubly amount, soak time, extraction time be the examination factor, each factor is selected three different levels, the factor level table sees Table 2.With water promotion yield of extract, puerarin extracted amount serves as to investigate index, determines optimised process, presses L
9(3
4) table does orthogonal test.
Table 2 factor level table
(1) water is promoted extractum preparation and yield determination method
Get Rhizoma Chuanxiong 15.6g, Flos Carthami 18.2g, Radix Puerariae 26.1g, Fructus Crataegi (enucleation) 31.4g (91.3g altogether) in the prescription ratio, decoct with water (weigh earlier before each the extraction, boil to preceding 10 minutes of stipulated time and weigh and add water again, boiled again 10 minutes) by Orthogonal Experiment and Design to former weight, filter, filtrate is concentrated into small size, moves in the evaporating dish of known weight, puts evaporate to dryness in the water-bath, in 105 ℃ of dryings 3 hours, put in the exsiccator and cooled off 0.5 hour, precision is weighed, and is calculated as follows dried cream yield.
(2) content of puerarin is measured in Radix Puerariae medical material and the dry extract
Content assaying method is with reference to " 2000 editions the 274th page of content of puerarin of Chinese pharmacopoeia are measured.
Chromatographic condition: methanol-water (25: 75) is a mobile phase, C
18Post (Yi Lite, 200*4.6mm, 5 μ) detects wavelength 250nm.
The preparation of reference substance solution: it is an amount of to get the puerarin reference substance, adds 30% ethanol and makes the solution that contains 0.0815mg among every 1ml, in contrast product solution.
The preparation of dry extract need testing solution: get dry extract, porphyrize is got about 0.4g, and accurate the title decides, and puts in the tool plug conical flask, precision adds 30% ethanol 50ml, claims decide weight, and reflux 30 minutes is put coldly, and weight decided in title, add 30% ethanol and supply the weight that subtracts mistake, shake up, filter, get subsequent filtrate, promptly.
The preparation of medical material need testing solution: get the about 0.8g of Radix Puerariae powder (crossing sieve No. three), the accurate title, decide, and puts in the conical flask, and precision adds 30% ethanol 15ml, claim to decide weight, reflux 30 minutes is put coldly, adds 30% ethanol and supplies the weight that subtracts mistake, shake up, filter, get subsequent filtrate, promptly.
Algoscopy: accurate respectively reference substance solution and each 5 μ l of need testing solution of drawing, inject chromatograph of liquid, measure, promptly.
This research is 0.365% with content of puerarin in the Radix Puerariae medical material.
(3) water is proposed orthogonal test scheme, result and variance analysis
Table 3 water is carried orthogonal test scheme and table as a result
Table 4 water is carried the dried cream yield of quadrature analysis of variance table
| Soruces of variation | Sum of deviation square | Degree of freedom | Variance | The F value | Significance |
| A | 1.1645 | 2 | 0.5822 | 13.8 | ＞0.05 |
| B | 0.6218 | 2 | 0.3109 | 7.4 | ＞0.05 |
| C | 2.2131 | 2 | 1.1065 | 26.2 | ＜0.05* |
| Error e | 0.08447 | 2 | 0.04223 |
Above intuitive analysis result shows that optimised process consists of A
2B
1C
2
Table 5 water is carried quadrature puerarin extracted amount analysis of variance table
| Soruces of variation | Sum of deviation square | Degree of freedom | Variance | The F value | Significance |
| A | 1.2898 | 2 | 0.6449 | 16.5 | ＞0.05 |
| B | 0.9362 | 2 | 0.4681 | 11.9 | ＞0.05 |
| C | 3.7448 | 2 | 1.8724 | 47.8 | ＜0.05* |
| Error e | 0.07829 | 2 | 0.03914 |
Wherein " * " looks into F-distribution critical table: F for significant difference is arranged
0.05(2,2)=19.00.
Show that from table 5 intuitive analysis result optimised process consists of A
2B
1C
2
Comprehensive above-mentioned dry extract yield and puerarin extracted amount The results of analysis of variance, both basically identicals, optimised process consists of A
2B
1C
2The material of promptly getting it filled decocts with water secondary, adds 10 times of water gagings 1.5 hours for the first time, adds 8 times of water gagings 1 hour for the second time.
2, flour extraction examination
The material of getting it filled is removed impurity, cleans, and medical material was put 55-65 ℃ of drying about 6 hours, makes water content surpass 5%, takes out, and puts coldly, pulverizes.
Get Radix Notoginseng, Radix Puerariae 500g, pulverize separately passes through 80 mesh sieves with the medicated powder after pulverizing, and weighs, and calculates flour extraction.The results are shown in Table 6,7.
The examination of table 6 Radix Notoginseng flour extraction is table as a result
| Tested number | Inventory (g) | Medicated powder (g) | Flour extraction (%) |
| 1 | 500 | 486.5 | 97.3 |
| 2 | 500 | 485.6 | 97.12 |
| 3 | 500 | 485.8 | 97.16 |
| Meansigma methods | 485.97 | 97.19 |
Experimental result shows: the average flour extraction of pseudo-ginseng is 97.19%.
The examination of table 7 Radix Puerariae flour extraction is table as a result
| Tested number | Inventory (g) | Medicated powder (g) | Flour extraction (%) |
| 1 | 500 | 488.2 | 97.64 |
| 2 | 500 | 486.4 | 97.28 |
| 3 | 500 | 487.0 | 97.4 |
| Meansigma methods | 487.2 | 97.44 |
Experimental result shows: the average flour extraction of Radix Puerariae medical material is 97.44%.
Can keep fully by technology products obtained therefrom effective ingredient of the present invention, and have good bioavailability.It is very important to provide Flos Carthami, Rhizoma Chuanxiong, Fructus Crataegi and rest radix puerariae to carry in the process at water in the technology of the present invention, and the key factor that can influence extraction effect comprises amount of water, extraction time, extraction time.These data all be that the inventor passes through repeatedly to test, checking repeatedly, from production cost, many-side such as extraction effect considerations draws.Thereby preparation technology of the present invention is reasonable, and whole technology is more perfect, can save cost preferably, is applicable to the requirement of industrialized great production well.
The specific embodiment
Embodiment 1
The Fructus Crataegi 157g of Radix Notoginseng 78g, Rhizoma Chuanxiong 78g, Flos Carthami 91g, Radix Puerariae 261g, enucleation is standby.Get Radix Notoginseng 78g, Radix Puerariae 130.5g, Radix Notoginseng, Radix Puerariae are removed impurity, clean, placed 55-65 ℃ of drying about 6 hours, make water content surpass 5%.Then, Radix Notoginseng, Radix Puerariae are pulverized, crossed 80 mesh sieves, become fine powder, standby.
All the other Flos Carthamis, Rhizoma Chuanxiong, Fructus Crataegi and rest radix puerariae decoct with water secondary, add for the first time 10 times of water gagings 1.5 hours, add 8 times of water gagings 1 hour, collecting decoction for the second time, filter, filtrate is concentrated into relative density for record the clear paste of 1.22-1.25 in the time of 80 ℃, adds Radix Puerariae fine powder, Radix Notoginseng fine powder, adds the 50g refined honey, mixing, place automatic pellet processing machine, make pill and put the coating pan internal rotation again, in the coating process, every 100g pill adds the active carbon of 0.5g.75 ℃ were descended dry 4 hours then.Promptly get naodesheng concentrate pill of the present invention.
Embodiment 2
Get Radix Notoginseng 233.5g, Rhizoma Chuanxiong 233.5g, Flos Carthami 272.5g, Radix Puerariae 781.4g, Fructus Crataegi (enucleation) 470.1g.
The above five tastes are got Radix Notoginseng 233.5g, Radix Puerariae 390.7g pulverize separately becomes fine powder, and all the other Flos Carthamis, Rhizoma Chuanxiong, Fructus Crataegi and rest radix puerariae decoct with water secondary, add for the first time 10 times of water gagings 1.5 hours, add 8 times of water gagings 1 hour, collecting decoction for the second time, filter, filtrate is concentrated into the clear paste that relative density is 1.22-1.25 (80 ℃), adds Radix Puerariae fine powder, Radix Notoginseng fine powder and the about 149.5g of refined honey, mixing, pill, bag active carbon clothing, drying, make 1000g, promptly.
Claims (7)
1, a kind of preparation technology of Chinese medicine naodesheng concentrate pill, raw material is: Radix Notoginseng 78g, Rhizoma Chuanxiong 78g, Flos Carthami 91g, Radix Puerariae 261g, the Fructus Crataegi 157g of enucleation, get Radix Notoginseng 78g, Radix Puerariae 130.5g pulverize separately becomes fine powder, all the other Flos Carthamis, Rhizoma Chuanxiong, Fructus Crataegi and rest radix puerariae decoct with water secondary, add for the first time 10 times of water gagings 1.5 hours, add for the second time 8 times of water gagings 1 hour, collecting decoction filters, and filtrate is concentrated into relative density for record 1.22～1.25 clear paste in the time of 80 ℃, add the Radix Puerariae fine powder, the Radix Notoginseng fine powder, the 50g refined honey, mixing, pill, coating, drying, promptly.
2, the preparation technology of a kind of Chinese medicine naodesheng concentrate pill according to claim 1 gets the Fructus Crataegi 470.1g of Radix Notoginseng 233.5g, Rhizoma Chuanxiong 233.5g, Flos Carthami 272.5g, Radix Puerariae 781.4g, enucleation, and refined honey 148-150g makes 1000g.
3, the preparation technology of a kind of Chinese medicine naodesheng concentrate pill according to claim 1 and 2 before Radix Notoginseng, Radix Puerariae are pulverized, removes impurity with Radix Notoginseng, Radix Puerariae, cleans, and places 55-65 ℃ of drying about 6 hours, makes water content surpass 5%.
4, the preparation technology of a kind of Chinese medicine naodesheng concentrate pill according to claim 1 and 2 gets Radix Notoginseng, Radix Puerariae pulverizing, crosses 80 mesh sieves, gets fine powder.
5, the preparation technology of a kind of Chinese medicine naodesheng concentrate pill according to claim 1 and 2, the Radix Notoginseng flour extraction is 97-98%, the average flour extraction of Radix Puerariae is 97-98%.
6, the preparation technology of a kind of Chinese medicine naodesheng concentrate pill according to claim 1 and 2, described drying are 75 ℃ of following dryings 4 hours.
7, the preparation technology of a kind of Chinese medicine naodesheng concentrate pill according to claim 1 and 2, in the coating process, every 100g pill adds the active carbon of 0.5g.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510032582 CN1823943A (en) | 2005-12-20 | 2005-12-20 | Preparation technology of Chinese medicine naodesheng concentrate pill |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010034134A1 (en) * | 2008-09-25 | 2010-04-01 | Weng Xiaotao | Preparation method of concentrated pill of chinese medicine |
| CN108066438A (en) * | 2017-11-27 | 2018-05-25 | 贵州浩诚药业有限公司 | Prevent Chinese medicine composition, drug of ischemic cerebrovascular disease and its preparation method and application |
| CN110583941A (en) * | 2019-08-06 | 2019-12-20 | 回音必集团安徽制药有限公司 | Preparation method of Naodesheng food |
| CN113577149A (en) * | 2021-07-12 | 2021-11-02 | 湖南天济草堂制药股份有限公司 | Preparation method of Naodesheng concentrated pill |
-
2005
- 2005-12-20 CN CN 200510032582 patent/CN1823943A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010034134A1 (en) * | 2008-09-25 | 2010-04-01 | Weng Xiaotao | Preparation method of concentrated pill of chinese medicine |
| CN108066438A (en) * | 2017-11-27 | 2018-05-25 | 贵州浩诚药业有限公司 | Prevent Chinese medicine composition, drug of ischemic cerebrovascular disease and its preparation method and application |
| CN110583941A (en) * | 2019-08-06 | 2019-12-20 | 回音必集团安徽制药有限公司 | Preparation method of Naodesheng food |
| CN113577149A (en) * | 2021-07-12 | 2021-11-02 | 湖南天济草堂制药股份有限公司 | Preparation method of Naodesheng concentrated pill |
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Open date: 20060830 |