CN1814071A - Zhangyanming capsule and preparing process - Google Patents
Zhangyanming capsule and preparing process Download PDFInfo
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- CN1814071A CN1814071A CN 200510032463 CN200510032463A CN1814071A CN 1814071 A CN1814071 A CN 1814071A CN 200510032463 CN200510032463 CN 200510032463 CN 200510032463 A CN200510032463 A CN 200510032463A CN 1814071 A CN1814071 A CN 1814071A
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Abstract
The invention is a Zhangyanming capsule and the preparing process thereof, using main materials: Grassleaf Sweetflag Rhizome 22.8g, Cassia Seed 30.6g, Desertliving Cistanche 37.8g, Kudzuvine Root 37.8g, Feather Cockscomb Seed 30.6g, Pilose Asiabell Root 48.6g, Simpleleaf Shrub Chastetree Fruit 30.6g, wolfberry fruit 48.6g, Plantain Seed 37.8g, White Paeony Root 45.6g, Common Macrocarpium Fruit 24.6g, Liquorice Root 22.8g, Chinese Dodder Seed 61.2g, Rhizoma Cimicifugae 7.8g, Hedge Prinsepia Nut without endocarp 37.8g, Flos Dendranthematis 37.8g, Pale Butterflybush Flower 37.8g, Szechuan Lovage Rhizome 30.6g, King Solomonseal Rhizome 37.8g, Prepared Rehmannia Root 61.2g, Amur Corktree Bark 30.6g and Membranous Milkvetch Root 48.6g and using starch as auxiliary material, where the weight ratio of dry plaster prepared of effective components to starch is (170-175):80. Its quality is more reliable and stable, dampproof. The preparing method is more perfect, more beneficial to fully retaining effective components and able to save cost.
Description
Technical field
Employed Chinese medicinal capsule of a kind of treatment oculopathy of the present invention cataract and preparation technology thereof.
Background technology
Medicine commonly used in the existing treatment cataract has ZHANGYANMING PIAN, has curative effect preferably for the cataract patient in treatment initial stage and mid-term.But former medicine belongs to that tablet Chinese medical concrete sheet is long disintegration, and the effective ingredient dissolution rate is slow, and is generally coated tablet, is unfavorable for that some avoids sugared disease patient and take, especially diabetics and obese patient, and the crowd of taking is subjected to certain restriction.Coated tablet coating operation is loaded down with trivial details, and it is attractive in appearance that external form is owed, and is prone to and goes mouldy, and is unfavorable for permanent preservation, obviously can not satisfy the demand of doctor patient in actual therapeutic.In addition, for not explanation of amount of water important in the extraction process, how to make technology of the present invention can reach best in original technology, if change dosage form, how its moulding process is finished, and whether the technology after the improvement is fit to industrialized great production, for the Chinese medicine worker, all be unknown.
Summary of the invention
It is reliable that purpose of the present invention aims to provide a kind of more stable quality, has protection against the tide, shortens disintegration, selects for doctor and the more medication of patient, and can produce better economic benefit ZHANGYANMING capsule.
It is more perfect that another object of the present invention aims to provide technology, is more conducive to the abundant reservation of effective ingredient, and save cost again, the preparation technology of ZHANGYANMING capsule.
The objective of the invention is to realize by following manner:
Effective ingredient of the present invention is: Rhizoma Acori Graminei 22.8g, Semen Cassiae 30.6g, Herba Cistanches 37.8g, Radix Puerariae 37.8g, Semen Celosiae 30.6g, Radix Codonopsis 48.6g, Fructus Viticis 30.6g, Fructus Lycii 48.6g, Semen Plantaginis 37.8g, Radix Paeoniae Alba 45.6g, Fructus Corni 24.6g, Radix Glycyrrhizae 22.8g, Semen Cuscutae 61.2g, Rhizoma Cimicifugae 7.8g, remove the Nux Prinsepiae 37.8g of endocarp, Flos Chrysanthemi 37.8g, Flos Buddlejae 37.8g, Rhizoma Chuanxiong 30.6g, Rhizoma Polygonati 37.8g, Radix Rehmanniae Preparata 61.2g, Cortex Phellodendri 30.6g, Radix Astragali 48.6g, adjuvant adopts starch, and the weight ratio that is made dried cream powder and starch by active ingredient is 170-175: 80.
The optimum weight ratio of dried cream powder of the present invention and starch is 170: 80.
Every capsules Chinese medicine active component is 170mg-175mg: 80mg with the content ratio of adjuvant.
Another object of the present invention realizes by following manner:
Preparation technology of the present invention is:
More than 22 the flavor, Semen Cassiae, Fructus Viticis, Semen Cuscutae, Semen Celosiae, Semen Plantaginis add boiling water and soaked 20 hours, add remaining Rhizoma Acori Graminei 17 flavor decocting in water secondaries then, each 2 hours, add the water of 8 times of amounts at every turn, filter, merging filtrate is condensed into to relative density 1.35 clear paste that record 60 ℃ the time, 60 ℃-70 ℃ of temperature, vacuum is vacuum drying under the 0.07-0.08Mpa condition, pulverize, dried cream powder 170-175g adds starch 80 grams again, get medicated powder, use 80% alcohol granulation, drying, encapsulated, make 1000, promptly.
Use 80% alcohol granulation, addition is 10% of a medicated powder, and unit is ml/g.
Exsiccant temperature after the granulation is controlled at 70-80 ℃.
Owing to do not illustrated that to adding the key factor that water doubly measures in this technical process the present invention has done following experiment in the former technology, so that draw this technology optimum process condition.
In preparation technology, Semen Cassiae, Fructus Viticis, Semen Cuscutae, Semen Celosiae, Semen Plantaginis add boiling water and soaked 20 hours, add Rhizoma Acori Graminei, Herba Cistanches, Radix Puerariae, Radix Codonopsis, Fructus Lycii, the Radix Paeoniae Alba, Fructus Corni, Radix Glycyrrhizae, Rhizoma Cimicifugae, Nux Prinsepiae (removing endocarp), Flos Chrysanthemi, Flos Buddlejae, Rhizoma Polygonati, Radix Rehmanniae Preparata, Cortex Phellodendri, the Radix Astragali, Rhizoma Chuanxiong 17 flavors then, decoct with water secondary, each 2 hours, filter, merging filtrate, serve as to investigate index now, adopt the preferred optimum process condition of orthogonal test with dry extract yield and peoniflorin extracted amount.
1.1, factor level design
Get 1/10 recipe quantity medical material, with add water doubly amount, extraction time, extraction time be the examination factor, each factor is selected three different levels, presses orthogonal test table L
9(3
4), be index with dry extract yield, peoniflorin extracted amount, carry out orthogonal test, the positive factor water-glass sees Table 1.
Table 1 factor level table
1.2, the preparation of dry extract and the calculating of yield
Get 1/10 recipe quantity medical material 80.94g altogether, by the Orthogonal Experiment and Design test, depend on pine torch, Fructus Viticis, Semen Cuscutae, Semen Celosiae, Semen Plantaginis adds boiling water and soaked 20 hours, with Rhizoma Acori Graminei, Herba Cistanches, Radix Puerariae, Radix Codonopsis, Fructus Lycii, the Radix Paeoniae Alba, Fructus Corni, Radix Glycyrrhizae, Rhizoma Cimicifugae, Nux Prinsepiae (removing endocarp), Flos Chrysanthemi, Flos Buddlejae, Rhizoma Polygonati, Radix Rehmanniae Preparata, Cortex Phellodendri, the Radix Astragali, Rhizoma Chuanxiong merges, decoct with water and (weigh earlier before each the extraction, boil to preceding 10 minutes of stipulated time and weigh and add water again to former weight, boiled again 10 minutes), filter, filtrate is concentrated into small size, get a certain amount ofly, transfer in the evaporating dish of known weight water bath method, again in 105 ℃ of dryings 3 hours, put in the exsiccator and cooled off 0.5 hour, precision is weighed, and is calculated as follows dried cream yield.
1.3, content of paeoniflorin is measured in white Peony Root and the dry extract
With reference to " the paeoniflorin content assay method is measured under Radix Paeoniae Rubra item of Chinese pharmacopoeia version in 2000.
Chromatographic condition: C
18Post (enlightening horse, 200*4.6mm, 5 μ); Mobile phase: methanol-water (3: 7); Detect wavelength 230nm; Flow velocity: 1ml/min.
The preparation of reference substance solution: it is an amount of to get the peoniflorin reference substance, adds methanol and makes the solution that contains 0.06mg among every 1ml, in contrast product solution.
The preparation of dry extract need testing solution: get the medicinal liquid under the orthogonal test item, be concentrated into thick paste, 70 ℃ of dryings 5 hours, get dry extract, porphyrize is got about 1g, the accurate title, decide, and puts in the 25ml measuring bottle, adds the about 20ml of methanol, supersound process 30 minutes (200W 40KHz) is taken out, and puts cold, add methanol to scale, shake up, filter, get filtrate, as need testing solution.
The preparation of white Peony Root need testing solution: get the about 2g of Radix Paeoniae Alba fine powder, the accurate title, decide, and puts in the 25ml measuring bottle, adds the about 20ml of methanol, soaked 4 hours, supersound process 30 minutes (200W 40KHz) is taken out, and puts coldly, adds methanol to scale, shake up, filter, get filtrate, as need testing solution.
Algoscopy: accurate respectively reference substance and each 5 μ l of need testing solution of drawing, inject chromatograph of liquid, measure.External standard method is calculated, promptly.
This research is 0.81% with content of paeoniflorin in the white Peony Root.
1.4, water proposes orthogonal test scheme, result and variance analysis
With dry extract yield, peoniflorin extracted amount is index, adopts orthogonal test, preferred optimum process condition, and orthogonal test scheme, result and The results of analysis of variance see Table 2,3,4.
Table 2 water is carried orthogonal test scheme and table as a result
| Tested number | A | B | C | D | Dried cream yield (%) | Peoniflorin extracted amount (mg) |
| 1 | 1 | 1 | 1 | 1 | 16.1 | 19.0 |
Table 3 water is carried the dried cream yield of quadrature analysis of variance table
| Soruces of variation | Sum of deviation square | Degree of freedom | Variance | The F value | Significance |
| A B C error e | 5.4866 0.02666 20.3466 1.04 | 2 2 2 2 | 2.7433 0.01333 10.1733 0.52 | 5.3 0.03 19.6 | ＞0.05 ＞0.05 ＜0.05* |
Wherein " * " looks into F-distribution critical table: F for significant difference is arranged
0.05(2,2)=19.00.Analysis result shows that optimised process consists of A
2B
1C
3
Table 4 water is carried the analysis of variance table of quadrature peoniflorin extracted amount
| Soruces of variation | Sum of deviation square | Degree of freedom | Variance | The F value | Significance |
| A B C error e | 0.1267 0.0067 2.22 0.02667 | 2 2 2 2 | 0.0633 0.00333 1.11 0.0133 | 4.8 0.3 83.3 | ＞0.05 ＞0.05 ＜0.05* |
Wherein " * " looks into F-distribution critical table: F for significant difference is arranged
0.05(2,2)=19.00.
From table 4 The results of analysis of variance as can be known: A the A factor
2＞A
3＞A
1, select best level A
2, B in the B factor
1＞B
3＞B
2, select best level B
1, C in the C factor
2＞C
3＞C
1, select best level C
2, analysis result shows: optimised process consists of A
2B
1C
2
Comprehensive above-mentioned The results of analysis of variance considers that the more dried cream yield of peoniflorin extracted amount is important, so the selection optimised process is A
2B
1C
2The material of promptly getting it filled decocts with water secondary, adds 8 times of water gagings 2 hours at every turn.
Because of concentrating and the dry inherent quality that directly influences medicine, because of the too high destruction that easily causes effective ingredient of its temperature, so investigate to concentrating condition and baking temperature.
2.1, concentrate the selection of condition
Get twice recipe quantity medical material 1618.8g altogether, extract, filter by above-mentioned preferred preferred plan, medicinal liquid is divided into halves, a concentrated in 100 ℃ of normal pressures, another part is in relative negative pressure 0.07-0.09Mpa, 60 ℃ of-70 ℃ of following concentrating under reduced pressure, all being concentrated into relative density is the thick paste of 1.35 (60 ℃ of heat are surveyed), observes concentrated effect.The results are shown in Table 5.
The investigation experiment of the different method for concentration of table 5
| Method for concentration | Be concentrated into relative density | Concentration time (min) | Appearance character |
| 100 ℃, normal pressure | 1.35 | 95 | Sticking wall loss is big, and color is dark |
| 60℃-70℃、 (0.07-0.09Mpa) | 1.35 | 60 | Not sticking wall, of light color |
Experimental result shows that it is serious that above-mentioned normal pressure concentrates the sticking wall of condition ointment, loses greatly, and the ointment color is dark, medicinal liquid heating temperature height, and concentration time is long; The sticking wall of thickening efficiency height under the reduced pressure, ointment lose for a short time, and the medicinal liquid heated time is lacked, and heating temperature is low, and flavour of a drug are dense, and color is better.Consider production cost and production cycle, so 60 ℃-70 ℃ of preferred temperature, relatively negative pressure 0.07-0.09Mpa is for concentrating condition.
2.2, the selection of drying condition
Get ten times of recipe quantity medical materials 8094g altogether, extract, filter by above-mentioned preferred preferred plan, it is the 1.35 (thick pastes of (60 ℃ of heat are surveyed) that the medicinal liquid concentrating under reduced pressure becomes relative density, be divided into two parts, at similarity condition lower berth layer, portion (60 ℃-70 ℃ of temperature, vacuum is 0.07-0.08Mpa) drying in vacuum drying oven, another part carries out drying in electric heating constant temperature (80 ℃) drying baker, the results are shown in Table 6.
Table 6 drying mode is preferably shown
| Drying mode | Drying time (h) | Dried cream character | Dried cream heavy (g) |
| Vacuum | 12 | Yellowish-brown, not sticking wall is cellular, and flavor is fragrant | 849.5 |
| Normal pressure (80 ℃) | 28 | Pitchy, sticking wall in bulk and hard, flavor is fragrant | 847.7 |
More than two kinds of drying meanss, must measure dried cream does not have obviously influence, but bigger to drying time, dried cream affect trait.
Under constant pressure and dry (80 ℃) condition, sticking wall is serious and by the wall part coking, dried cream color is darker, and hard in bulk be unfavorable for pulverizing, and drying time is long, and drying efficiency is low; Under vacuum drying (60 ℃-70 ℃ of temperature, vacuum is 0.07-0.08Mpa) condition, the not sticking wall of dried cream, drying time is short, the efficient height, dried cream color is more shallow, and dried cream is cellular, and is more crisp, helps pulverizing.So the drying mode of this product is selected vacuum drying mode (60 ℃-70 ℃ of temperature, vacuum is 0.07-0.08Mpa).
3, Study on Forming
Because of the dry extract hygroscopicity is strong, unsuitable directly encapsulating capsule is unfavorable for storing, so need to add appropriate amount of auxiliary materials, overcomes shortcomings such as the easy moisture absorption of extractum.Therefore supplementary product kind, consumption and granulation condition are investigated, test method and result are as follows:
3.1, the selection of supplementary product kind and consumption
This product is the water extracted immersing paste preparation, if do not add appropriate amount of auxiliary materials, viscosity is big during granulation, should not granulate, easily lump when dry, product in storage process easily the moisture absorption, go mouldy, variable color, adjuvant commonly used has starch, micropowder silica gel, select starch as excipient, and the consumption of starch investigated, be solvent with 80% ethanol, the system soft material, granulate with 16 mesh sieves, the results are shown in Table 7.
The selection test of table 7 material consumption
| Dried cream powder: starch | The granulation situation |
| 170∶40 170∶60 170∶80 | Agglomerating, it is not agglomerating to be difficult for sieving, and it is not agglomerating more easily to sieve, and easily sieves non-blocking screen |
The above results shows: dried cream powder: starch is solvent in 170: 80 ratio mixing with 80% ethanol, and is not agglomerating during granulation, non-blocking screen, made uniform particles.
3.2, the selection of system soft material wetting agent
This product adopts ethanol to granulate as wetting agent, and comes to determine concentration of ethanol by experiment.Get three parts of mixed powders, every part of 100g adds Different concentrations of alcohol and stirs 16 orders. and the sieve series grain, 70 ℃ of dryings are taken out, and are evaluation index with the granulation situation, the results are shown in Table 8.
The selection test of table 8 wetting agent
| Medicated powder heavy (g) | Concentration of alcohol | The ethanol consumption | The granulation situation |
| 100 100 100 | 95％ 90％ 80％ | 10ml 10ml 10ml | Bad granulation, loose, the granulation of easily sieving, loose slightly, the granulation of easily sieving is easily sieved |
Experimental result shows: adopt 80% ethanol to make wetting agent, do not lump during granulation, easily sieve, so this product adopts 80% ethanol as wetting agent, addition is about 10% of a medicated powder.
3.3, the selection of drying condition
After granule is made, should be in time dry.Exsiccant temperature generally is controlled at 70-80 ℃, and temperature should rise gradually when dry, so that the evaporation of intragranular moisture average rate.The granule water content is controlled at less than 2%.
Table 9 ZHANGYANMING PIAN and capsule quality comparison sheet
The above results shows: the quality standard of capsule is significantly increased than former dosage form.
In sum, product of the present invention is that a kind of more stable quality is reliable, has protection against the tide, shortens disintegration, selects for doctor and the more medication of patient, and can produce better economic benefit ZHANGYANMING capsule.Preparation technology of the present invention is more perfect, is more conducive to the abundant reservation of effective ingredient, and saves cost again.
The specific embodiment
Embodiment 1
Effective ingredient of the present invention is: Rhizoma Acori Graminei 22.8g, Semen Cassiae 30.6g, Herba Cistanches 37.8g, Radix Puerariae 37.8g, Semen Celosiae 30.6g, Radix Codonopsis 48.6g, Fructus Viticis 30.6g, Fructus Lycii 48.6g, Semen Plantaginis 37.8g, Radix Paeoniae Alba 45.6g, Fructus Corni 24.6g, Radix Glycyrrhizae 22.8g, Semen Cuscutae 61.2g, Rhizoma Cimicifugae 7.8g, the Nux Prinsepiae 37.8g that removes endocarp, Flos Chrysanthemi 37.8g, Flos Buddlejae 37.8g, Rhizoma Chuanxiong 30.6g, Rhizoma Polygonati 37.8g, Radix Rehmanniae Preparata 61.2g, Cortex Phellodendri 30.6g, Radix Astragali 48.6g.
More than 22 the flavor, Semen Cassiae, Fructus Viticis, Semen Cuscutae, Semen Celosiae, Semen Plantaginis add boiling water and soaked 20 hours, add remaining Rhizoma Acori Graminei 17 flavor decocting in water secondaries then, each 2 hours, the water that at every turn adds 8 times of amounts filters merging filtrate, be condensed into to relative density 1.35 clear paste that record 60 ℃ the time, 60 ℃-70 ℃ of temperature, vacuum is vacuum drying under the 0.07-0.08Mpa condition, pulverizes, dried cream powder 170g, add starch 80 grams again, get the about 250g of medicated powder, use 80% alcohol granulation, addition is 10% of a medicated powder, unit/ml/g.70-80 ℃ of drying, encapsulated, make 1000, promptly.
Embodiment 2-4
In order to verify and improve the preparation technology that experimentation goes out, so that reach the operability of production and to the adaptability of relevant devices, we amplify 10 times with preparation prescription and feed intake, to under laboratory condition, studying the optimum process technology condition that obtains, carry out three batches of pilot scale researches, and each key process technology parameter of itemized record.And three batches of pilot products are carried out quality inspection, the results are shown in Table 14.
Three batches of pilot scale production technologies of table 10 tables of data
| Lot number | Embodiment 2 | Embodiment 3 | Embodiment 4 | |
| Total inventory (kg, 10 times of recipe quantities) | 8.094 | 8.094 | 8.094 | |
| Dry extract (kg) | 1.71 | 1.70 | 1.73 | |
| Starch (kg) | 0.8 | 0.8 | 0.8 | |
| Particle weight (kg) | 2.43 | 2.47 | 2.46 | |
| Finished product theoretical yield (grain) | 10000 | 10000 | 10000 | |
| Finished product is actual must measure (grain) | 9560 | 9583 | 9643 | |
| Finished product yield (%) | 95.6 | 95.83 | 96.43 | |
| Character | Be capsule, content is brown granular or powder; Sweet in the mouth, little acid. | Be capsule, content is brown granular or powder; Sweet in the mouth, little acid. | Be capsule, content is brown granular or powder; Sweet in the mouth, little acid. | |
| Quality examination | Differentiate | Detect Radix Puerariae | Detect Radix Puerariae | Detect Radix Puerariae |
| Detect Cortex Phellodendri | Detect Cortex Phellodendri | Detect Cortex Phellodendri | ||
| Detect ferulic acid | Detect ferulic acid | Detect ferulic acid | ||
| Detect Fructus Lycii | Detect Fructus Lycii | Detect Fructus Lycii | ||
| Detect Semen Cassiae | Detect Semen Cassiae | Detect Semen Cassiae | ||
| Detect Radix Glycyrrhizae | Detect Radix Glycyrrhizae | Detect Radix Glycyrrhizae | ||
| Detect astragaloside | Detect astragaloside | Detect astragaloside | ||
| Moisture content (%) | 4.7 | 4.5 | 4.5 | |
| Disintegration (min) | 15 | 15 | 15 | |
| Content uniformity | Up to specification | Up to specification | Up to specification | |
| Paeoniflorin content (mg/ grain) | 0.149 | 0.148 | 0.143 | |
| Bacterial population (individual/g) | 50 | 45 | 40 | |
| Fungi count (individual/g) | ＜10 | ＜10 | ＜10 | |
| Escherichia coli (individual/g) | Do not detect | Do not detect | Do not detect |
Above result shows: ZHANGYANMING capsules preparation technique condition is reasonable, feasible; Extract, concentrate, methods such as drying, preparation adapt with the amplification production equipment; Prepared product quality is qualified, can be used for commercial production.
Claims (6)
1, a kind of ZHANGYANMING capsule, its effective ingredient is: Rhizoma Acori Graminei 22.8g, Semen Cassiae 30.6g, Herba Cistanches 37.8g, Radix Puerariae 37.8g, Semen Celosiae 30.6g, Radix Codonopsis 48.6g, Fructus Viticis 30.6g, Fructus Lycii 48.6g, Semen Plantaginis 37.8g, Radix Paeoniae Alba 45.6g, Fructus Corni 24.6g, Radix Glycyrrhizae 22.8g, Semen Cuscutae 61.2g, Rhizoma Cimicifugae 7.8g, remove the Nux Prinsepiae 37.8g of endocarp, Flos Chrysanthemi 37.8g, Flos Buddlejae 37.8g, Rhizoma Chuanxiong 30.6g, Rhizoma Polygonati 37.8g, Radix Rehmanniae Preparata 61.2g, Cortex Phellodendri 30.6g, Radix Astragali 48.6g, it is characterized in that: adjuvant adopts starch, and the weight ratio that is made dried cream powder and starch by active ingredient is 170-175: 80.
2, a kind of ZHANGYANMING capsule according to claim 1, it is characterized in that: the optimum weight ratio of dried cream powder and starch is 170: 80.
3, a kind of ZHANGYANMING capsule according to claim 1 is characterized in that: every capsules Chinese medicine active component is 170mg-175mg: 80mg with the content ratio of adjuvant.
4, the described a kind of ZHANGYANMING capsules preparation technique of claim 1 is:
A, Semen Cassiae, Fructus Viticis, Semen Cuscutae, Semen Celosiae, Semen Plantaginis add boiling water and soaked 20 hours;
B, add remaining Rhizoma Acori Graminei 17 flavors, the decocting in water secondary, each 2 hours, add the water of 8 times of amounts at every turn, filter, merging filtrate,
C, filtrate are condensed into to relative density 1.35 clear paste that record 60 ℃ the time, and 60 ℃-70 ℃ of temperature, vacuum is vacuum drying under the 0.07-0.08Mpa condition,
D, dry extract is pulverized, is got dried cream powder 170-175g, add starch 80 grams again, medicated powder, use 80% alcohol granulation, drying, encapsulated, make 1000, promptly.
5, a kind of ZHANGYANMING capsules preparation technique according to claim 1 is characterized in that: use 80% alcohol granulation, addition is 10% of a medicated powder, unit/ml/g.
6, a kind of ZHANGYANMING capsules preparation technique according to claim 1, it is characterized in that: the exsiccant temperature after the granulation is controlled at 70-80 ℃, and vacuum is 0.07-0.08Mpa.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100324637A CN100361650C (en) | 2005-11-30 | 2005-11-30 | Zhangyanming capsule and preparing process |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100324637A CN100361650C (en) | 2005-11-30 | 2005-11-30 | Zhangyanming capsule and preparing process |
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|---|---|
| CN1814071A true CN1814071A (en) | 2006-08-09 |
| CN100361650C CN100361650C (en) | 2008-01-16 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103040974A (en) * | 2013-01-21 | 2013-04-17 | 广东岭南职业技术学院 | Traditional Chinese medicine compound eye drops for preventing cataract and preparation method thereof |
| CN104027510A (en) * | 2014-06-20 | 2014-09-10 | 广州白云山中一药业有限公司 | Application of epation in preparation of medicines for preventing and treating xerophthalmia |
-
2005
- 2005-11-30 CN CNB2005100324637A patent/CN100361650C/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103040974A (en) * | 2013-01-21 | 2013-04-17 | 广东岭南职业技术学院 | Traditional Chinese medicine compound eye drops for preventing cataract and preparation method thereof |
| CN104027510A (en) * | 2014-06-20 | 2014-09-10 | 广州白云山中一药业有限公司 | Application of epation in preparation of medicines for preventing and treating xerophthalmia |
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| Publication number | Publication date |
|---|---|
| CN100361650C (en) | 2008-01-16 |
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