CN1895360A - Preparation of tablets for harmonizing menstruation and nourishing face - Google Patents
Preparation of tablets for harmonizing menstruation and nourishing face Download PDFInfo
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- CN1895360A CN1895360A CN 200610051097 CN200610051097A CN1895360A CN 1895360 A CN1895360 A CN 1895360A CN 200610051097 CN200610051097 CN 200610051097 CN 200610051097 A CN200610051097 A CN 200610051097A CN 1895360 A CN1895360 A CN 1895360A
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Abstract
A Chinese medicine in the form of tablet for regulating menstruation and beautifying skin is prepared from 6 Chinese-medicinal materials including astragalus root, Yunnan madder root, lucid ligustrum fruit, notoginseng, etc through pulverizing notoginseng, decocting others three times, vacuum concentrating, alcohol depositing three times, recovering alcohol, drying, pulverizing, mixing it with notoginseng powder, granulating, drying, die pressing and coating.
Description
Technical field
The invention belongs to medical technical field, relate in particular to a kind of production method of menstruation-regulating face-beautifying sheet.
Background technology
" national standard for traditional Chinese medicines compilation " Chinese patent medicine provincial standard rising national standard part---surgery, the fascicle WS-10418 of gynecological (ZD-0418)-2002 menstruation-regulating face-beautifying capsule.Because content is Chinese medical concrete and raw medicinal herbs powder, easily the moisture absorption is rotten.Do not have clear paste relative density in paste volume behind concrete amount of water, the water extract-alcohol precipitation, the alcohol deposit fluid concentration technology, precipitate with ethanol in its extraction process with technical parameters such as ethanol allocation proportions, so its technology is uncontrollable, quality is also unstable.
Summary of the invention
A kind of drug quality that the objective of the invention is to overcome above-mentioned shortcoming and provide is stable, and technology is controlled, and Film coated tablets can secluding air, and it is rotten to be difficult for the moisture absorption, and can cover the production method of the menstruation-regulating face-beautifying sheet of bad smell.
The production method of a kind of menstruation-regulating face-beautifying sheet of the present invention comprises:
1250 parts of 1250 parts of Fructus Ligustri Lucidi of 1500 parts of Radixs Astragali of Caulis et Folium fici Tikouae
200 parts of 250 portions of Radix Notoginseng of 750 parts of Herba Pratiae Nummulariae of Radix Rubiae Yunnanensis
Above Six-element, Radix Notoginseng powder is broken into fine powder, and it is standby to sterilize; The five tastes such as all the other Caulis et Folium fici Tikouaes decoct with water each 2 hours three times, for the first time add 10 times of water gagings, second and third time respectively adds 8 times of water gagings, collecting decoction, filter, the filtrate vacuum and low temperature is concentrated into the clear paste that relative density is 1.20 (70～80 ℃), and 70% ethanol precipitate with ethanol are measured three times with 10 times in the cooling back, for the first time 5 times of amounts, 3 times of amounts, 2 times of amounts for the third time for the second time, merge alcohol deposit fluid, left standstill 2 hours, and got supernatant and reclaim ethanol, and be concentrated into relative density 1.35-1.40 (70-80 ℃) thick paste.In 60～86 ℃ of dryings, pulverize, with the Radix Notoginseng powder mix homogeneously, granulate, dry (55 ℃), and tabletting, the bag film-coat, packing, promptly.
The production method of above-mentioned menstruation-regulating face-beautifying sheet, wherein: granulating with binding agent is that weight concentration is a 85-95% ethanol.
The production method of above-mentioned menstruation-regulating face-beautifying sheet, wherein: granulating with binding agent is that weight concentration is 85% ethanol.
The production method of above-mentioned menstruation-regulating face-beautifying sheet, wherein: lubricant is a magnesium stearate, its consumption is the 0.1-1% of total amount.
The production method of above-mentioned menstruation-regulating face-beautifying sheet, wherein: lubricant is a magnesium stearate, its consumption is 0.5% of a total amount.
The present invention compared with prior art, clear and definite amount of water specifically, precipitate with ethanol had so both made technology controlled, stable with technical parameters such as ethanol allocation proportions, had guaranteed that again extract character is consistent with former dosage form simultaneously.The preparations shaping part then adopts to add an amount of suitable adjuvant, and the mixed-powder pelletizing press sheet is investigated powder and particulate flowability and hygroscopicity and compression molding effect etc. by test, determines the optimised process of tabletting.Impurity-eliminating effect of the present invention is good, and the gained drug quality is good, and Film coated tablets can secluding air, and it is rotten to be difficult for the moisture absorption, thereby increases the stability of tablet, and can cover bad smell.
The specific embodiment
Further specify beneficial effect of the present invention by following experimental example:
One, technical study is investigated index choice
Because Radix Notoginseng directly is used as medicine with the crude drug powder among the we, need carry out the medical material that water carries is: Caulis et Folium fici Tikouae, the Radix Astragali, Fructus Ligustri Lucidi, Radix Rubiae Yunnanensis, the five tastes such as Herba Pratiae Nummulariae, and the effect that the Radix Astragali has QI invigorating, nourishes blood in the side, astragaloside is one of effective ingredient in the Milkvetch Root, and Astragaloside content assay method maturation, so the content of astragaloside is that Study on extraction is investigated index in our the selective extraction liquid.
Two, water absorption experiment
Take by weighing 5 parts of all the other five tastes medical materials except that Radix Notoginseng by 1/5 of recipe quantity respectively, respectively add 10 times of water gagings and be dipped to the saturating heart of the whole moistenings of medical material, filter, calculate water absorption, the results are shown in Table 1.
Table 1 menstruation-regulating face-beautifying slice prescription medical material water absorption rate
| Tested number | 1 | 2 | 3 | 4 | 5 | Average water absorption rate (%) |
| Water absorption rate (%) | 203 | 209 | 198 | 202 | 189 | 200.2 |
Average as can be seen from the above table water absorption is the twice of medical material.
Three, concrete amount of water experiment
Method is as follows:
Get three parts of 1 times of each 5000g of formula ratio menstruation-regulating face-beautifying sheet medical material (the astragaloside theoretical amount is 593.75mg in each part crude drug Radix Astragali) except that Radix Notoginseng.The water that adds 6 times of amounts, 8 times of amounts, 10 times of amounts respectively decocts each 2 hours three times, collecting decoction filters, and vacuum concentration is to the clear paste of relative density 1.20 (70～80 ℃), measuring the wherein extracted amount of astragaloside, serves as to investigate index with the extracted amount of astragaloside, the results are shown in Table 2.
The concrete amount of water experimental result table of table 2
| Tested number | Amount of water (multiple) | The extracted amount of astragaloside (mg) | The rate of transform of astragaloside (%) |
| 1 2 3 | 6 8 10 | 331.5 369.9 371.7 | 55.8 62.3 62.6 |
As seen from the above table: amount of water is 8 times during with 10 times, the astragaloside amount difference of extracting is little, but height when adding 6 times of water gagings and extracting, and energy-saving and cost-reducingly considers from producing, determine that the amount of water in the extraction process is 8 times, because the medical material water absorption is about 2 times of medical material first.So optimised process is decided to be: decoct with water three times, add 10 times of water gagings for the first time, second, third time adds 8 times of water gagings and decocts, and decocts 2 hours at every turn, and collecting decoction filters.
Four, alcohol precipitation process experiment
With alcoholic acid three kinds of allocation proportions: experimentized in 4: 3: 35: 3: 26: 2: 2.
Experimental technique: take by weighing 3 times of recipe quantity medical materials by prescription and amount to 15000g (Caulis et Folium fici Tikouae 4500g Radix Astragali 3750g Fructus Ligustri Lucidi 3750g Radix Rubiae Yunnanensis 2250g Herba Pratiae Nummulariae 750g), extract by best decocting process, extracting solution is concentrated into the clear paste that relative density is 1.20 (70～80 ℃), records that to contain the astragaloside total amount in the clear paste be 1135.8mg.It is divided into 3 parts, (every part contains astragaloside 378.6mg,) add totally 10 times of amount 70% ethanol precipitate with ethanol three times by above-mentioned three kinds of allocation proportions respectively after the cooling, merge alcohol deposit fluid, left standstill 2 hours, and got supernatant and reclaim ethanol, in 60～86 ℃ of dryings, pulverize, measure the dried cream yield and the astragaloside rate of transform.Experimentizing with the influence to Astragaloside content in the extract powder of the ethanol precipitate with ethanol of different allocation proportions below, is index with the content of astragaloside.Experimental result sees Table 3.
The different ethanol allocation proportions of table 3 are to the influence of alcohol precipitation process
| Sequence number | The ethanol allocation proportion | Dried cream yield (%) | Contain astragaloside amount (mg) | The rate of transform of astragaloside (%) |
| 1 2 3 | 4∶3∶3 5∶3∶2 6∶2∶2 | 7.1 5.6 5.5 | 348.6 366.4 329.8 | 92.1 96.8 87.1 |
Above result shows that the ethanol allocation proportion is 5: 3: 2 impurity-eliminating effect the bests in the alcohol precipitation process.
Five, the selection of powder and granule tabletting mode
Select extract powder tabletting or after making granule with the assay method of angle of repose with Radix Notoginseng powder mixing direct compression.Method is as follows:
Get Radix Notoginseng fine powder 200g and extract powder 280g mix homogeneously, standby.
Get Radix Notoginseng fine powder 200g and extract powder 280g mix homogeneously, make binding agent with 85% ethanol, 18 mesh sieves are granulated, 55 ℃ of dryings, and 20 mesh sieve granulate get granule, and are standby.
Adopt the fixed funnel method, with the series connection of 3 funnels and be fixed in the height place of 2cm on the graph paper of horizontal positioned, carefully sample is poured in the uppermost funnel till the medicated powder cone tip that nethermost funnel forms touches bell mouth along hopper walls respectively, measure the diameter (measuring repeatedly 3 times) of conical base by graph paper, according to formula tg α=height/radius, calculate angle of repose.The results are shown in Table 4.
Table 4 measurement result angle of repose
As can be known from the above table: mobility of particle is better than powder flowbility, therefore adopts the granule tabletting.
Six, the selection of binding agent
Select for use Different concentrations of alcohol to make binding agent, observe molding particles and granulation situation, result such as table 5.
The selection of table 5 binding agent
| The binding agent kind | Molding effect |
| 95% ethanol, 90% ethanol, 85% ethanol, 80% ethanol | Loose particles, granulate easily, the many loose particles of fine powder, granulate easily, the many uniform particles of fine powder, the easy particle bond of granulating, it is difficult to granulate |
As can be known from the above table: the 85-95% granulating efficiency is comparatively desirable, and preferred 85% alcohol granulation effect is the most desirable.
Seven, selection of lubricants
Because the magnesium stearate lubricant greasy property is good, consumption is little, and selecting it is that the lubricant quantity test sees Table 6.
Table 6 selection of lubricants
| Tested number | Magnesium stearate ratio (%) | α ° of angle of repose |
| 1 2 3 4 5 6 | 0.1 0.3 0.4 0.5 0.6 1 | 40 39 36 32 31 28 |
As can be known from the above table: the magnesium stearate with 0.1-1% is made lubricant, all can reach promising result.For reducing supplementary product consumption, preferred 0.5% magnesium stearate is made lubricant.
Eight, the experiment of particle drying technology
Contain moisture in the granule, need drying after the granulation.For guaranteeing its water content, now its drying process is investigated below 5%.Get four parts of each 20g of wet granular, drying is 4 hours in different temperatures underlying air dry oven, result such as table 7.
Table 7 baking temperature investigation table
| Numbering | Sampling amount (g) | Baking temperature (℃) | Water content (%) | The granulate situation |
| 1 2 3 4 | 20 20 20 20 | 50 55 65 75 | 5.5 3.6 2.8 2.5 | Be easier to easy in bulk, difficult granulate in bulk, difficult granulate |
As can be known from the above table: the best when baking temperature is controlled at 55 ℃.Therefore in granulation, adopt 55 ℃ of dryings.
Seven, the purpose of coating
Because of the plain sheet of this product is Chinese medicine extract and crude drug powder, the easy moisture absorption, but bag film-coat secluding air prevents the plain sheet moisture absorption; Also can cover the bad flavor of smelling of medicine simultaneously, be convenient to take, so tablet of the present invention is carried out coating.
Embodiment 1:
The following raw material of weighing:
Caulis et Folium fici Tikouae 1500g Radix Astragali 1250g Fructus Ligustri Lucidi 1250g
Radix Rubiae Yunnanensis 750g Herba Pratiae Nummulariae 250g Radix Notoginseng 200g
Above Six-element, Radix Notoginseng powder is broken into fine powder, and it is standby to sterilize; The five tastes such as all the other Caulis et Folium fici Tikouaes decoct with water each 2 hours three times, add for the first time 10 times of water gagings, second, respectively add 8 times of water gagings for three times, collecting decoction, filter, the filtrate vacuum and low temperature is concentrated into the clear paste that relative density is 1.20 (70～80 ℃), and 70% ethanol precipitate with ethanol are measured three times with 10 times in the cooling back, for the first time 5 times of amounts, 3 times of amounts, 2 times of amounts for the third time for the second time, merge alcohol deposit fluid, left standstill 2 hours, and got supernatant and reclaim ethanol, and be concentrated into 1.40 (70～80 ℃), in 60～86 ℃ of dryings, pulverize, with the Radix Notoginseng powder mix homogeneously, the ethanol 50ml of adding 85% makes binding agent system soft material, granulate with 18 mesh sieves, dry (55 ℃), 20 mesh sieve granulate add 2.5 gram magnesium stearate and make lubricant and always be mixed even, tabletting, the bag film-coat, packing, promptly.
Embodiment 2:
The following raw material of weighing:
Caulis et Folium fici Tikouae 1500g Radix Astragali 1250g Fructus Ligustri Lucidi 1250g
Radix Rubiae Yunnanensis 750g Herba Pratiae Nummulariae 250g Radix Notoginseng 200g
Above Six-element, Radix Notoginseng powder is broken into fine powder, and it is standby to sterilize; The five tastes such as all the other Caulis et Folium fici Tikouaes decoct with water each 2 hours three times, add for the first time 10 times of water gagings, second, respectively add 8 times of water gagings for three times, collecting decoction, filter, the filtrate vacuum and low temperature is concentrated into the clear paste that relative density is 1.20 (70～80 ℃), and 70% ethanol precipitate with ethanol are measured three times with 10 times in the cooling back, for the first time 5 times of amounts, 3 times of amounts, 2 times of amounts for the third time for the second time, merge alcohol deposit fluid, left standstill 2 hours, and got supernatant and reclaim ethanol, and be concentrated into 1.35 (70～80 ℃), in 60～86 ℃ of dryings, pulverize, with the Radix Notoginseng powder mix homogeneously, the ethanol 70ml of adding 90% makes binding agent system soft material, granulate with 18 mesh sieves, dry (55 ℃), 20 mesh sieve granulate add 1.5 gram magnesium stearate and make lubricant and always be mixed even, tabletting, the bag film-coat, packing, promptly.
Embodiment 3:
The following raw material of weighing:
Caulis et Folium fici Tikouae 1500g Radix Astragali 1250g Fructus Ligustri Lucidi 1250g
Radix Rubiae Yunnanensis 750g Herba Pratiae Nummulariae 250g Radix Notoginseng 200g
Above Six-element, Radix Notoginseng powder is broken into fine powder, and it is standby to sterilize; The five tastes such as all the other Caulis et Folium fici Tikouaes decoct with water each 2 hours three times, add for the first time 10 times of water gagings, second, respectively add 8 times of water gagings for three times, collecting decoction, filter, the filtrate vacuum and low temperature is concentrated into the clear paste that relative density is 1.20 (70～80 ℃), and 70% ethanol precipitate with ethanol are measured three times with 10 times in the cooling back, for the first time 5 times of amounts, 3 times of amounts, 2 times of amounts for the third time for the second time, merge alcohol deposit fluid, left standstill 2 hours, and got supernatant and reclaim ethanol, and be concentrated into 1.37 (70～80 ℃), in 60～86 ℃ of dryings, pulverize, with the Radix Notoginseng powder mix homogeneously, the ethanol 50ml of adding 95% makes binding agent system soft material, granulate with 18 mesh sieves, dry (55 ℃), 20 mesh sieve granulate add 2.5 gram magnesium stearate and make lubricant and always be mixed even, tabletting, the bag film-coat, packing, promptly.
Claims (6)
1, a kind of production method of menstruation-regulating face-beautifying sheet is characterized in that:
1250 parts of 1250 parts of Fructus Ligustri Lucidi of 1500 parts of Radixs Astragali of Caulis et Folium fici Tikouae
200 parts of 250 portions of Radix Notoginseng of 750 parts of Herba Pratiae Nummulariae of Radix Rubiae Yunnanensis
Above Six-element, Radix Notoginseng powder is broken into fine powder, and it is standby to sterilize; The five tastes such as all the other Caulis et Folium fici Tikouaes decoct with water each 2 hours three times, for the first time add 10 times of water gagings, second and third time respectively adds 8 times of water gagings, collecting decoction, filter, the filtrate vacuum and low temperature is concentrated into 70～80 ℃, and to survey relative densities be 1.20 clear paste, and 70% ethanol precipitate with ethanol are measured three times with 10 times in the cooling back, for the first time 5 times of amounts, 3 times of amounts, 2 times of amounts for the third time for the second time, merge alcohol deposit fluid, left standstill 2 hours, and got supernatant and reclaim ethanol, in 60～86 ℃ of dryings, pulverize, with the Radix Notoginseng powder mix homogeneously, granulate 55 ℃ of dryings, tabletting, the bag film-coat, packing, promptly.
2, the production method of menstruation-regulating face-beautifying sheet as claimed in claim 1, wherein: get supernatant and reclaim ethanol, and be concentrated into 70-80 ℃ of survey relative density 1.35-1.40 thick paste.
3, the production method of menstruation-regulating face-beautifying sheet as claimed in claim 1 or 2, wherein: granulating with binding agent is that weight concentration is a 85-95% ethanol.
4, the production method of menstruation-regulating face-beautifying sheet as claimed in claim 3, wherein: granulating with binding agent is that weight concentration is 85% ethanol.
5, the production method of menstruation-regulating face-beautifying sheet as claimed in claim 3, wherein: lubricant is a magnesium stearate, its consumption is the 0.1-1% of total amount.
6, the production method of menstruation-regulating face-beautifying sheet as claimed in claim 4, wherein: lubricant is a magnesium stearate, its consumption is 0.5% of a total amount.
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| CN 200610051097 CN1895360A (en) | 2006-06-15 | 2006-06-15 | Preparation of tablets for harmonizing menstruation and nourishing face |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200610051097 CN1895360A (en) | 2006-06-15 | 2006-06-15 | Preparation of tablets for harmonizing menstruation and nourishing face |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104800332A (en) * | 2015-04-22 | 2015-07-29 | 海南葫芦娃制药有限公司 | Menstruation regulating beautifying tablet and preparation method thereof |
| CN110051789A (en) * | 2018-01-19 | 2019-07-26 | 余屋山 | It is a kind of to treat protrusion of lumber intervertebral disc liquid medicine and preparation method thereof |
| CN110302274A (en) * | 2019-07-30 | 2019-10-08 | 数源汇通（北京）医药科技有限公司 | Alleviate the Traditional Chinese drug mixture and preparation method thereof of stomach disease |
| CN112569314A (en) * | 2020-12-29 | 2021-03-30 | 北京悦康科创医药科技股份有限公司 | Menstruation regulating and face nourishing medicinal preparation and preparation method thereof |
-
2006
- 2006-06-15 CN CN 200610051097 patent/CN1895360A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104800332A (en) * | 2015-04-22 | 2015-07-29 | 海南葫芦娃制药有限公司 | Menstruation regulating beautifying tablet and preparation method thereof |
| CN104800332B (en) * | 2015-04-22 | 2017-10-13 | 海南葫芦娃药业集团股份有限公司 | Menstruation-regulating face-beautifying piece and preparation method thereof |
| CN110051789A (en) * | 2018-01-19 | 2019-07-26 | 余屋山 | It is a kind of to treat protrusion of lumber intervertebral disc liquid medicine and preparation method thereof |
| CN110302274A (en) * | 2019-07-30 | 2019-10-08 | 数源汇通（北京）医药科技有限公司 | Alleviate the Traditional Chinese drug mixture and preparation method thereof of stomach disease |
| CN112569314A (en) * | 2020-12-29 | 2021-03-30 | 北京悦康科创医药科技股份有限公司 | Menstruation regulating and face nourishing medicinal preparation and preparation method thereof |
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