CN104800332B - Menstruation-regulating face-beautifying piece and preparation method thereof - Google Patents
Menstruation-regulating face-beautifying piece and preparation method thereof Download PDFInfo
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Abstract
It is broken by Radix Notoginseng nanopowder the invention discloses a kind of menstruation-regulating face-beautifying piece and preparation method thereof, take second half to be extracted with remaining five tastes, second half together adds granulation with auxiliary material, then using specific auxiliary material, specific part by weight, so as to improve panax ginsenoside Rg1 contents, disintegration time limited is fast, and steady quality is easy to take, bioavilability is high, and its preparation method is simple, is not required to any special installation, it is adapted to industrialized production.
Description
Technical field
The invention belongs to traditional Chinese medicine preparation field, and in particular to a kind of menstruation-regulating face-beautifying piece and preparation method thereof.
Background technology
Menstruation-regulating face-beautifying piece/capsule prescription is Yi nationality side.The Yi nationality, distributed over Yunnan, Sichuan and Guizhou be in Minorities In China with a long history, offspring and population compared with
One of wider nationality in many, Distribution Area, is mainly distributed on In Southwest China Ailaoshan, Yunnan Wumeng Shan Mountain area, Sichuan Liangshan District
The Huairen one in state and Guizhou Province with and Guangxi Zhuang Autonomous Region some areas.During same the Nature and disease struggle,
The Yi nationality, distributed over Yunnan, Sichuan and Guizhou people have accumulated the traditional medicine with Yi Nationality Medicine characteristic.Yi nationality's medicine rises in Nan Zhao Dali medicine and pharmacology, absorbs
The elite of local medical science, Hindu medicine and Persian medical science, systematic theory of medicine basis and abundant clinical application practice, Yi nationality
Doctor has gradually formed the medical theory of oneself in the period of Ming and Qing.The current industrialization development degree of Yi nationality, distributed over Yunnan, Sichuan and Guizhou's medicine be only second to Tibetan medicine and
Seedling medicine, Yi nationality's medicine is expected to turn into Chinese the third-largest ethnic drug.
Because there is advantageous natural environment the Yi Nationality Area, Yi ethnic medicine resources very abundant, includes dynamic by up to thousand kinds
Thing medicine, mineral drug, autonomic drug, wherein with autonomic drug and animal drugs with relatively broad.Radix Astragali bowl spares benefit in menstruation-regulating face-beautifying prescription
Gas, the fruit of glossy privet tonifies the liver and kidney, and rubia yunnanensis is the distinctive local nationalities' medicine in Yunnan, and Herba Pratiae Nummulariae, Caulis et Folium fici Tikouae, pseudo-ginseng are then with the Yi Nationality Area
For the main place of production, the work(of invigorate blood circulation, all medicines share are respectively provided with, it is adaptable to menoxenia and its caused dysmenorrhoea, complexion
It is light dark or have blackening.
The formulation of dispersible tablet is applied to menstruation-regulating face-beautifying preparation by Publication No. CN1895360A Chinese patent application first,
Its preparation method is that pseudo-ginseng is ground into fine powder, is sterilized standby;Remaining five tastes is added water to cook three times, collecting decoction, filtration, is concentrated into
Alcohol precipitation three times after clear cream, cooling, merging takes supernatant to reclaim ethanol, dry, pulverize, with Radix Notoginseng powder mixing granulation.But use
The action for the tablet that this kind of method is obtained is slow, and assimilation effect is bad, and main cause may is that disintegration time limited and dissolution rate are relatively low,
It has impact on the curative effect of tablet;Meanwhile, the content of ginsenoside Rg1 is generally relatively low in the tablet pseudo-ginseng, causes drug effect slow, controls curative effect
Fruit is not good enough.
The content of the invention
The invention provides a kind of menstruation-regulating face-beautifying piece and preparation method thereof, the menstruation-regulating face-beautifying piece has preferable disintegration time limited
And dissolution rate, it is easy to absorb;And the preparation method process is simple, quality controllable and suitable for industrialized production.
A kind of menstruation-regulating face-beautifying piece, is made up of the medicinal material and auxiliary material of following parts by weight:
Wherein, 50%~80% pseudo-ginseng extracts active component with water and is used as medicine, and remaining pseudo-ginseng is used as medicine in the form of medicinal powder.
The inventors discovered that, the tablet compactibility obtained using CN1895360A Chinese patent application method is poor,
Its disintegrating property and dissolution rate are very poor, have a strong impact on it and absorb and curative effect.When by pseudo-ginseng a part using water extract activity into
After point being used as medicine, it has unexpectedly been found that disintegrating property and dissolution rate are increased substantially, and are conducive to the absorption of medicine.In addition, pressing
The content of the main active ginsenoside Rg1 of the menstruation-regulating face-beautifying piece obtained according to this kind of method also has a certain degree of liter
It is high.
Preferably, described menstruation-regulating face-beautifying piece is made up of the medicinal material and auxiliary material of following parts by weight:
Present invention also offers a kind of preparation method of described menstruation-regulating face-beautifying piece, comprise the following steps:
(1) pseudo-ginseng is ground into by fine powder using superfine communication technique, takes 20%~50% fine powder standby;
(2) 50%~80% in pseudo-ginseng fine powder after step (1) is crushed adds water carry out ultrasonic extraction with remaining five tastes,
The filter vacuum low temperature being filtrated to get is condensed into clear cream, carries out alcohol precipitation, dry extract is dry, pulverize to obtain in 60~86 DEG C;
(3) the standby fine powder of step (1), the dry extract of step (2) and microcrystalline cellulose, superfine silica gel powder are mixed, plus
Enter ethanol and mix softwood processed, wet granular is made in 18~20 mesh sieves, drying, 18~20 mesh sieve whole grains, add hydroxypropylcellulose,
Carboxyrnethyl starch sodium and magnesium stearate, are well mixed, tabletted, film coating, obtain described menstruation-regulating face-beautifying piece.
Preferably, the particle diameter after step (1) ultramicro grinding is 200~300nm.
Preferably, in step (2), ultrasonic extraction number of times is 2 times, the consumption of each water is 8~10 times of medicinal material weight,
Extraction time is 30~60min, and 40~80kw of ultrasonic power, temperature is 30~60 DEG C.
Preferably, in step (2), filter vacuum low temperature is concentrated into the clear cream that relative density is 1.20 (70~80 DEG C).
Preferably, in step (2), alcohol precipitation temperature is 5~10 DEG C, alcohol content is 50~80% (percents by volume), alcohol
Heavy 3~6h.
Preferably, step (3) wet granular drying temperature is 50~70 DEG C.
Compared with the existing technology, beneficial effects of the present invention are embodied in:
(1) present invention is broken by Radix Notoginseng nanopowder, takes a part to be extracted with remaining five tastes, and another part together adds with auxiliary material
Enter granulation, so as to improve panax ginsenoside Rg1 contents;
(2) the meticulous screening of the invention by auxiliary material, made grain graininess is uniform, slice, thin piece hardness, slice, thin piece finish
Aspect has the particle being made better than traditional handicraft.
Embodiment
Embodiment 1
Prescription:
Preparation method:
(1) pseudo-ginseng is ground into by 200~300nm fine powders using superfine communication technique, takes half fine powder standby.
(2) five tastes such as second half pseudo-ginseng fine powder of step (1) and Caulis et Folium fici Tikouae are added into octuple weight water ultrasonic extraction 2 times, every time
40min, ultrasonic power 60kw, temperature are 45 DEG C, and it is 1.20 (70~80 that gained filter vacuum low temperature, which is concentrated into relative density,
DEG C) clear cream, after cooling with 10 times amount 70% ethanol alcohol precipitations, alcohol precipitation temperature be 10 DEG C, alcohol precipitation 5h.Supernatant is taken to reclaim ethanol,
Dry extract is dry, pulverize to obtain in 75 DEG C;
(3) the standby pseudo-ginseng fine powder of step (1) and dry extract, microcrystalline cellulose, superfine silica gel powder are mixed, adds 80%
Ethanol mixes softwood processed, and wet granular is made in 18 mesh sieves, dries, 18 mesh sieve whole grains.Add hydroxypropylcellulose, carboxyrnethyl starch sodium
And magnesium stearate, it is well mixed, tabletted, film coating produces menstruation-regulating face-beautifying piece.
Embodiment 2
Prescription:
Preparation method:
(1) pseudo-ginseng is ground into by 200~300nm fine powders using superfine communication technique, takes half fine powder standby.
(2) five tastes such as second half pseudo-ginseng fine powder of step (1) and Caulis et Folium fici Tikouae are added into octuple weight water ultrasonic extraction 2 times, every time
50min, ultrasonic power 70kw, temperature are 50 DEG C, and it is 1.20 (70~80 that gained filter vacuum low temperature, which is concentrated into relative density,
DEG C) clear cream, after cooling with 10 times amount 70% ethanol alcohol precipitations, alcohol precipitation temperature be 10 DEG C, alcohol precipitation 5h.Supernatant is taken to reclaim ethanol,
Dry extract is dry, pulverize to obtain in 75 DEG C;
(3) step (1) pseudo-ginseng fine powder and dry extract, microcrystalline cellulose, superfine silica gel powder are mixed, adds 80% ethanol and mix
Softwood processed is closed, wet granular is made in 18 mesh sieves, is dried, 18 mesh sieve whole grains.Add hydroxypropylcellulose, carboxyrnethyl starch sodium and tristearin
Sour magnesium, is well mixed, tabletted, film coating produces menstruation-regulating face-beautifying piece.
Embodiment 3
Prescription:
Preparation method:
(1) pseudo-ginseng is ground into by 200~300nm fine powders using superfine communication technique, takes 20% fine powder (about 4kg) standby.
(2) five tastes such as the remaining 16kg pseudo-ginseng fine powder of step (1) and Caulis et Folium fici Tikouae are added eight times and measures water ultrasonic extraction 2 times, often
Secondary 40min, ultrasonic power 60kw, temperature are 45 DEG C, and it is 1.20 (70~80 that gained filter vacuum low temperature, which is concentrated into relative density,
DEG C) clear cream, after cooling with 10 times amount 70% ethanol alcohol precipitations, alcohol precipitation temperature be 10 DEG C, alcohol precipitation 5h.Supernatant is taken to reclaim ethanol,
Dry extract is dry, pulverize to obtain in 75 DEG C;
(3) the standby pseudo-ginseng fine powder of step (1) and dry extract, microcrystalline cellulose, superfine silica gel powder are mixed, adds 80%
Ethanol mixes softwood processed, and wet granular is made in 18 mesh sieves, dries, 18 mesh sieve whole grains.Add hydroxypropylcellulose, carboxyrnethyl starch sodium
And magnesium stearate, it is well mixed, tabletted, film coating produces menstruation-regulating face-beautifying piece.
Comparative example 1
Prescription:
Preparation method:
(1) pseudo-ginseng is ground into by 200~300nm fine powders using superfine communication technique, it is standby.
(2) five tastes such as Caulis et Folium fici Tikouae are added eight times and measures water ultrasonic extraction 2 times, each 40min, ultrasonic power 60kw, temperature
For 45 DEG C, gained filter vacuum low temperature is concentrated into the clear cream that relative density is 1.20 (70~80 DEG C), with 10 times of amounts after cooling
70% ethanol alcohol precipitation, alcohol precipitation temperature is 10 DEG C, alcohol precipitation 5h.Take supernatant to reclaim ethanol, dry extract is dry, pulverize to obtain in 75 DEG C
Powder;
(3) step (1) pseudo-ginseng fine powder and dry extract, microcrystalline cellulose, superfine silica gel powder are mixed, adds 80% ethanol and mix
Softwood processed is closed, wet granular is made in 18 mesh sieves, is dried, 18 mesh sieve whole grains.Add hydroxypropylcellulose, carboxyrnethyl starch sodium and tristearin
Sour magnesium, is well mixed, tabletted, film coating produces menstruation-regulating face-beautifying piece.
Comparative example 2
Prescription:
Preparation method:
(1) pseudo-ginseng is ground into 120 mesh fine powders, sterilizes standby.
(2) five tastes such as remaining Caulis et Folium fici Tikouae, are added water to cook three times, are added water 10 times and are measured for the first time, and second, add water 8 for the third time
Measure, decoct 2 hours every time, collecting decoction again, filtration, it is 1.20 (70~80 DEG C) that filter vacuum low temperature, which is concentrated into relative density,
Clear cream, measures 70% ethanol alcohol precipitation three times with 10 times after cooling, gained precipitation solution stands 2 hours, takes supernatant to reclaim ethanol, in 60
~86 DEG C dry, pulverize to obtain dry extract;
(3) step (1) pseudo-ginseng fine powder and dry extract, microcrystalline cellulose, superfine silica gel powder are mixed, adds 80% ethanol and mix
Softwood processed is closed, wet granular is made in 18 mesh sieves, is dried, 18 mesh sieve whole grains.Add hydroxypropylcellulose, carboxyrnethyl starch sodium and tristearin
Sour magnesium, is well mixed, tabletted, film coating produces menstruation-regulating face-beautifying piece.
Comparative example 3
Prescription:
Preparation method:
(1) pseudo-ginseng is ground into 120 mesh fine powders, sterilizes standby.
(2) five tastes such as remaining Caulis et Folium fici Tikouae, are added water to cook three times, are added water 10 times and are measured for the first time, and second, add water 8 for the third time
Measure, decoct 2 hours every time, collecting decoction again, filtration, it is 1.20 (70~80 DEG C) that filter vacuum low temperature, which is concentrated into relative density,
Clear cream, measures 70% ethanol alcohol precipitation three times with 10 times after cooling, gained precipitation solution stands 2 hours, takes supernatant to reclaim ethanol, in 60
~86 DEG C dry, pulverize to obtain dry extract;
(3) step (1) pseudo-ginseng fine powder and dry extract, microcrystalline cellulose are mixed, add 80% ethanol and mix softwood processed,
Wet granular is made in 18 mesh sieves, dries, 18 mesh sieve whole grains.Again plus dextrin and magnesium stearate, it is well mixed, it is tabletted, wrap thin
Film clothing, produces menstruation-regulating face-beautifying piece.
Comparative example 4
Prescription:
Preparation method:
(1) pseudo-ginseng is ground into by 200~300nm fine powders using superfine communication technique, takes 20% fine powder (13kg) standby.
(2) five tastes such as the remaining 7kg pseudo-ginseng fine powder of step (1) and Caulis et Folium fici Tikouae are added eight times and measures water ultrasonic extraction 2 times, every time
40min, ultrasonic power 60kw, temperature are 45 DEG C, and it is 1.20 (70~80 that gained filter vacuum low temperature, which is concentrated into relative density,
DEG C) clear cream, after cooling with 10 times amount 70% ethanol alcohol precipitations, alcohol precipitation temperature be 10 DEG C, alcohol precipitation 5h.Supernatant is taken to reclaim ethanol,
Dry extract is dry, pulverize to obtain in 75 DEG C;
(3) the standby pseudo-ginseng fine powder of step (1) and dry extract, microcrystalline cellulose, superfine silica gel powder are mixed, adds 80%
Ethanol mixes softwood processed, and wet granular is made in 18 mesh sieves, dries, 18 mesh sieve whole grains.Add hydroxypropylcellulose, carboxyrnethyl starch sodium
And magnesium stearate, it is well mixed, tabletted, film coating produces menstruation-regulating face-beautifying piece.
Comparative example 5
Prescription:
Preparation method:
(1) pseudo-ginseng is ground into by 200~300nm fine powders using superfine communication technique.
(2) five tastes such as step (1) pseudo-ginseng fine powder and Caulis et Folium fici Tikouae are added eight times and measures water ultrasonic extraction 2 times, each 40min surpasses
Acoustic power 60kw, temperature is 45 DEG C, and gained filter vacuum low temperature is concentrated into the clear cream that relative density is 1.20 (70~80 DEG C),
With 10 times of 70% ethanol alcohol precipitations of amount after cooling, alcohol precipitation temperature is 10 DEG C, alcohol precipitation 5h.Supernatant is taken to reclaim ethanol, in 75 DEG C of dryings,
Crush to obtain dry extract;
(3) dry extract, microcrystalline cellulose, superfine silica gel powder are mixed, adds 80% ethanol and mix softwood processed, in 18 mesh sieves
Wet granular is made, dries, 18 mesh sieve whole grains.Hydroxypropylcellulose, carboxyrnethyl starch sodium and magnesium stearate are added, is well mixed, pressure
Piece is made, film coating produces menstruation-regulating face-beautifying piece.
Menstruation-regulating face-beautifying piece sample prepared by embodiment 1~3 and comparative example 1~5 carry out respectively disintegration, character, property,
The detection methods such as content are respectively according to version in 2005《Chinese Pharmacopoeia》Two annex I A methods detections, the results are shown in Table 1.
The related check data of the menstruation-regulating face-beautifying piece of table 1
Testing result in table 1, is used as medicine, another part uses crude drug after a certain amount of pseudo-ginseng is extracted
Powder is used as medicine, and can effectively improve the disintegrating property and dissolution rate of tablet;When the medicinal powder underweight of extraction, disintegrating property and
The amplitude that dissolution rate is improved is not obvious, still, is used as medicine by the way of whole medicinal powder is all using extraction active component, disintegrative
Can on the contrary it decline with dissolution rate.Meanwhile, the mode of extraction also can produce large effect to reaction result, when being changed to decoction to surpass
After sound is extracted, the content of active ingredient and dissolution rate is significantly improved, it is possible to decoct the decomposition that result in active component.In addition,
The selection of auxiliary material also has on disintegrating property greatly to be influenceed, and inappropriate auxiliary material can also be such that disintegrating property significantly declines.
Menstruation-regulating face-beautifying piece sample prepared by embodiment 1 and comparative example 1 carries out placing 6 months under the conditions of accelerated test respectively
Disintegration, content detection are carried out, detection method is respectively according to version in 2005《Chinese Pharmacopoeia》Two annex I A methods detections, knot
Fruit is shown in Table 2.
The accelerated test result of table 2
As a result show:Sample is placed 6 months under the conditions of accelerated test, and its disintegration time limited, character, property, content etc. are
Significant change does not occur, and each hydraulic performance decline of comparative example 1 is substantially, therefore the present invention is better than prior art.
Claims (8)
1. a kind of menstruation-regulating face-beautifying piece, it is characterised in that be made up of the medicinal material and auxiliary material of following parts by weight:
Wherein, 50%~80% pseudo-ginseng extracts active component with water and is used as medicine, and remaining pseudo-ginseng is used as medicine in the form of medicinal powder.
2. menstruation-regulating face-beautifying piece according to claim 1, it is characterised in that be made up of the medicinal material and auxiliary material of following parts by weight:
3. a kind of preparation method of menstruation-regulating face-beautifying piece as claimed in claim 1 or 2, it is characterised in that comprise the following steps:
(1) pseudo-ginseng is ground into by fine powder using superfine communication technique, takes 20%~50% fine powder standby;
(2) 50%~80% in pseudo-ginseng fine powder after step (1) is crushed adds water carry out ultrasonic extraction with remaining gomi herbs,
The filter vacuum low temperature being filtrated to get is condensed into clear cream, carries out alcohol precipitation, dry extract is dry, pulverize to obtain in 60~86 DEG C;
(3) the standby fine powder of step (1), the dry extract of step (2) and microcrystalline cellulose, superfine silica gel powder are mixed, adds second
Alcohol mixes softwood processed, and wet granular is made in 18~20 mesh sieves, dries, and 18~20 mesh sieve whole grains add hydroxypropylcellulose, carboxylic first
Sodium starch and magnesium stearate, are well mixed, tabletted, film coating, obtain described menstruation-regulating face-beautifying piece.
4. the preparation method of menstruation-regulating face-beautifying piece according to claim 3, it is characterised in that after step (1) ultramicro grinding
Particle diameter is 200~300nm.
5. the preparation method of menstruation-regulating face-beautifying piece according to claim 3, it is characterised in that in step (2), ultrasonic extraction time
Number is 2 times, and the consumption of each water is 8~10 times of medicinal material weight, and extraction time is 30~60min, ultrasonic power 40~
80kw, temperature is 30~60 DEG C.
6. the preparation method of menstruation-regulating face-beautifying piece according to claim 3, it is characterised in that in step (2), filter vacuum is low
Temperature is concentrated into the clear cream that relative density is 1.20.
7. the preparation method of described menstruation-regulating face-beautifying piece according to claim 3, it is characterised in that in step (2), alcohol precipitation
Temperature is 5~10 DEG C, and alcohol content is 50~80%, 3~6h of alcohol precipitation.
8. the preparation method of menstruation-regulating face-beautifying piece according to claim 3, it is characterised in that wet granular is dried in step (3)
Temperature is 50~70 DEG C.
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Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1552367A (en) * | 2003-06-03 | 2004-12-08 | 毛友昌 | Menstruation regulating and face nourishing pills and their preparation |
CN1759867A (en) * | 2005-07-22 | 2006-04-19 | 师宇 | Granules of Chinese traditional medicine for treating women's irregular menses |
CN1765380A (en) * | 2005-09-02 | 2006-05-03 | 北京润德康医药技术有限公司 | Menstruation-regulating face-beautifying Chinese medicinal formulation and its preparation method |
CN1895360A (en) * | 2006-06-15 | 2007-01-17 | 贵州太和制药有限公司 | Preparation of tablets for harmonizing menstruation and nourishing face |
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2015
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Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1552367A (en) * | 2003-06-03 | 2004-12-08 | 毛友昌 | Menstruation regulating and face nourishing pills and their preparation |
CN1759867A (en) * | 2005-07-22 | 2006-04-19 | 师宇 | Granules of Chinese traditional medicine for treating women's irregular menses |
CN1765380A (en) * | 2005-09-02 | 2006-05-03 | 北京润德康医药技术有限公司 | Menstruation-regulating face-beautifying Chinese medicinal formulation and its preparation method |
CN1895360A (en) * | 2006-06-15 | 2007-01-17 | 贵州太和制药有限公司 | Preparation of tablets for harmonizing menstruation and nourishing face |
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