CN104857087A - Pharmaceutic preparation with blood glucose reducing effect, and preparation method and application of pharmaceutic preparation - Google Patents
Pharmaceutic preparation with blood glucose reducing effect, and preparation method and application of pharmaceutic preparation Download PDFInfo
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- CN104857087A CN104857087A CN201510297471.8A CN201510297471A CN104857087A CN 104857087 A CN104857087 A CN 104857087A CN 201510297471 A CN201510297471 A CN 201510297471A CN 104857087 A CN104857087 A CN 104857087A
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Abstract
The invention belongs to the field of drugs, and discloses a pharmaceutic preparation with a blood glucose reducing effect. The pharmaceutic preparation comprises 20 parts of beet root, 18 parts of varnish tree wood, 20 parts of kalanchoe spathulata, 15 parts of warty thladiantha, 20 parts of false indigo root, 18 parts of polygala crotalarioides Buch.-Ham, 16 parts of black Chinese olive kernel, 14 parts of apocynum venetum, 18 parts of pongamia pinnata pierre ex merr, and 20 parts of root of delavay clovershrub. The dosage form can be granule, tablet and capsule. The invention further discloses a preparation method which comprises the following steps: adding water for decoction, concentrating, performing alcohol precipitation, carrying out spray drying, grinding obtained particles into dry extract powder, and adding auxiliary materials to prepare the needed preparation. The invention further discloses application of the pharmaceutic preparation in preparation of a drug for reducing blood glucose.
Description
Technical field
The present invention relates to pharmaceutical preparation, be specifically related to a kind of pharmaceutical preparation with effect of lowering blood sugar and its preparation method and application.
Background technology
The medicine of current clinical treatment 2 type is except insulin, and mainly oral antidiabetic drug, is roughly divided into sulphanylureas, biguanides, pharmaceutical preparation, other antidiabetic drugs and adjuvant drug.But its side effect of these Oral Chemicals is mainly manifested in all has certain detrimental effect to blood phase, liver function, renal function, diabetes mellitus's property cardiovascular and cerebrovascular complication can be caused, easily occur hypoglycemic reaction, irritant to gastrointestinal, generation anorexia, Nausea and vomiting are even suffered from diarrhoea.Therefore select efficient and can life-time service without any side effects, curative effect is reliable, the hypoglycemic medicine of taking convenience is badly in need of, medicine has certain curative effect for treatment diabetes, contrast Western medicine has the features such as curative effect is high, toxic and side effects is little, but the curative effect of current pharmaceutical preparation treatment diabetes is not remarkable, cannot play the advantage of TCM treatment of diabetes.
Summary of the invention
Goal of the invention: in order to solve the problem, the object of the present invention is to provide one can fall hypoglycemic pharmaceutical preparation.
Technical scheme: the object of the invention is by following scheme realize:
Have a pharmaceutical preparation for effect of lowering blood sugar, the active component contained by it is prepared from: Radix Betae 20 parts, Lignum toxicodendri verniciflni 18 parts, Herba kalanchoes spathulatae 20 parts, Herba Thladiantghae verrucosae 15 parts, Radix indigoferae Pseudotinctoriae 20 parts, Radix Polygalae Crotalarioidis 18 parts, Semen Canarii Pimelae 16 parts, Herba Apocyni veneti 14 parts, Semen Pongamiae Pinnatae 18 parts, Radix Campylotropis Delavayi 20 parts by following raw materials in part by weight proportioning.
Described have hypoglycemic pharmaceutical preparation is fallen, preparation method comprises the steps: that getting above-mentioned medical material merges, decoct with water twice, collecting decoction, when being concentrated into 65 DEG C, relative density is 1.10-1.20, add ethanol, stir, make alcohol content by volume percentage calculation reach 65-85%, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.20-1.30 and reclaims ethanol, and by concentrated solution spraying dry, gained granular powder is broken into dry extract, add adjuvant, make granule, tablet, capsule.
Described have the pharmaceutical preparation reducing blood glucose effect, and in preparation method, decocting condition is: amount of water is the 8-12 times amount of medical material weight for the first time, decocts 1-2h, and second time amount of water is the 6-10 times amount of medical material weight, decocts 1-2h.
Described have the pharmaceutical preparation reducing blood glucose effect, and spray drying condition described in preparation method is: inlet temperature is 90-110 DEG C, and leaving air temp is 60-90 DEG C, and temperature of charge is 60-90 DEG C, and atomizing pressure is 0.2-0.5 MPa, and spray velocity is 1-10ml/s.
Described pharmaceutical preparation has the application reduced in blood glucose effect medicine in preparation.
Radix Betae is the root of Li section Zhi Wu Chard dish.Lignum toxicodendri verniciflni is the heartwood of Anacardiaceae plant Toxicodendron verniciflnum (Stokes) F. A. Barkley (Rhus verniciflua Stokes).Herba kalanchoes spathulatae is the herb of crassulaceae plants Herba kalanchoes spathulatae.Herba Thladiantghae verrucosae is the herb of cucurbitaceous plant Herba Thladiantghae verrucosae.Radix indigoferae Pseudotinctoriae is the root of leguminous plant horse sour jujube.Radix Polygalae Crotalarioidis is the root of milk wort Radix Polygalae Crotalarioidis.Semen Canarii Pimelae is the kernel of olive subject plant Fructus Canarii Pimelae.Herba Apocyni veneti is the herb of apocynaceae plant Herba Apocyni veneti.Semen Pongamiae Pinnatae is the seed of leguminous plant Semen Pongamiae Pinnatae.Radix Campylotropis Delavayi is the root of the leguminous plant southwest Hang Zi tip.
From theory of Chinese medical science; Radix Betae, Lignum toxicodendri verniciflni, Herba kalanchoes spathulatae heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling is monarch drug altogether, Herba Thladiantghae verrucosae, Radix indigoferae Pseudotinctoriae, Radix Polygalae Crotalarioidis, Semen Canarii Pimelae promoting diuresis to eliminate dampness and promoting QI circulation are ministerial drug, increase the effect of monarch drug blood circulation promoting and blood stasis dispelling, Herba Apocyni veneti, Semen Pongamiae Pinnatae, Radix Campylotropis Delavayi coordinating the actions of various ingredients in a prescription, all medicines are harmonious, play blood circulation promoting and blood stasis dispelling altogether, effect that clearing away heat and promoting production of body fluid eliminates the phlegm the turbid descending, for the treatment of diabetes.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
Embodiment 1: Qu Radix Betae 20g, Lignum toxicodendri verniciflni 18g, Herba kalanchoes spathulatae 20g, Herba Thladiantghae verrucosae 15g, Radix indigoferae Pseudotinctoriae 20g, Radix Polygalae Crotalarioidis 18g, Semen Canarii Pimelae 16g, Herba Apocyni veneti 14g, Semen Pongamiae Pinnatae 18g, Radix Campylotropis Delavayi 20g medical material, mixing, decoct with water twice, first time adds water as 8 times amount of medical material weight, decoct 1.5h, second time adds water as 6 times amount of medical material weight, decoct 1h, collecting decoction, filter, filtrate is concentrated into relative density 1.10 (65 DEG C), adding ethanol in proper amount makes alcohol content (volume fraction) reach 65%, stir, leave standstill 24 hours, filter, filtrate recycling ethanol is also concentrated into the concentrated solution of relative density 1.20 (65 DEG C), it is spray-dried that (condition is inlet temperature is 100 DEG C, leaving air temp is 80 DEG C, temperature of charge is 80 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 5ml/s.), be ground into dry extract, then add suitable dextrin, mix homogeneously, with appropriate 80% ethanol wet, soft material processed, cross 14 mesh sieves and granulate, 70 DEG C of dryings, 60 order granulate, obtain granule.
Embodiment 2: Qu Radix Betae 20g, Lignum toxicodendri verniciflni 18g, Herba kalanchoes spathulatae 20g, Herba Thladiantghae verrucosae 15g, Radix indigoferae Pseudotinctoriae 20g, Radix Polygalae Crotalarioidis 18g, Semen Canarii Pimelae 16g, Herba Apocyni veneti 14g, Semen Pongamiae Pinnatae 18g, Radix Campylotropis Delavayi 20g medical material, mixing, decoct with water twice, add water as 10 times amount of medical material weight time, decoct 2h, second time adds water as 8 times amount of medical material weight, decoct 1h, collecting decoction, filter, filtrate is concentrated into relative density 1.15 (65 DEG C), adding ethanol in proper amount makes alcohol content (volume fraction) reach 75%, stir, leave standstill 24 hours, filter, filtrate recycling ethanol is also concentrated into the concentrated solution of relative density 1.25 (65 DEG C), it is spray-dried that (condition is inlet temperature is 120 DEG C, leaving air temp is 90 DEG C, temperature of charge is 80 DEG C, atomizing pressure is 0.3 MPa, spray velocity is 7.5/s.), be ground into dry extract, then add appropriate Icing Sugar, mix homogeneously, with appropriate 80% ethanol wet, soft material processed, cross 30 mesh sieves and granulate, in 70 ~ 80 DEG C of dryings, with 60 mesh sieve granulate, tabletting, sugar coating, subpackage, outer package, censorship is qualified, obtains finished product.
Embodiment 3: Qu Radix Betae 20g, Lignum toxicodendri verniciflni 18g, Herba kalanchoes spathulatae 20g, Herba Thladiantghae verrucosae 15g, Radix indigoferae Pseudotinctoriae 20g, Radix Polygalae Crotalarioidis 18g, Semen Canarii Pimelae 16g, Herba Apocyni veneti 14g, Semen Pongamiae Pinnatae 18g, Radix Campylotropis Delavayi 20g medical material, mixing, decoct with water twice, first time adds water as 10 times amount of medical material weight, decoct 1.5h, second time adds water as 8 times amount of medical material weight, decoct 1.5h, collecting decoction, filter, filtrate is concentrated into relative density 1.15 (65 DEG C), adding ethanol in proper amount makes alcohol content (volume fraction) reach 75%, stir, leave standstill 24 hours, filter, filtrate recycling ethanol is also concentrated into the extractum of relative density 1.25 (65 DEG C), it is spray-dried that (condition is inlet temperature is 120 DEG C, leaving air temp is 90 DEG C, temperature of charge is 90 DEG C, atomizing pressure is 0.4 MPa, spray velocity is 7.5/s.), be ground into dry extract, cross No. 6 sieves, reinstall No. 1 capsule finished product.
Embodiment 4: fall hypoglycemic pharmacodynamic study
Laboratory animal: Kunming mouse (20 ± 2g) is male, and Shanghai Slac Experimental Animal Co., Ltd. provides, production licence: SCXK (Shanghai) 2007-0005.
Experimental agents: invent this pharmaceutical preparation, prepares by above-described embodiment 1 method.
Positive drug diabetes pill, Guangzhou Zhongyi Medicine Industry Co., Ltd's product, lot number 20130310, specification is 30g/ bottle, every bottle of l20 grain, and 10 is 2.5g, and calculate by per kilogram mice, namely positive drug group gives diabetes pill 0.65g/kg.
Instrument and reagent: alloxan (C
4h
2n
2o
4h
2o, molecular weight 160.08), blood glucose meter, full automatic biochemical apparatus, 721 spectrophotometers, microplate reader, balance.
After adaptability raises 1 day, get 10 mices at random as normal group, another 90 animal fasting 3-5 hour, survey fasting glucose, as this batch of animal basal plasma glucose value.Animal fasting subsequently 24 hours (freely drinking water), lumbar injection alloxan (using front Fresh) 130mg/kg modeling, animal fasting 5 hours after 5 days, surveys blood glucose, and blood glucose value 10 ~ 25mmol/L is hyperglycemia model success animal.
Select hyperglycemia model animal 40, by the blood sugar level grouping of fasting 3-5 hour, select 1 model control group and 4 dosage groups (between group, difference is not more than 1.1mmol/L) at random, often organize 10 animals, dosage group gives variable concentrations given the test agent, and model control group gives solvent, continuous 30 days, survey fasting blood sugar (fasting is with before experiment), more each treated animal blood glucose value and blood glucose decline percentage rate.
The effect ((X scholar D) that the present invention declines to the sugared model mice blood glucose of height
Compare * * * p<0.001 with normal group, compare ###p<0.001 with model group, compare with positive drug group
$p<0.05.
Medicine of the present invention has hypoglycemic effect to hyperglycemia mice, significantly reduces, illustrate that the present invention has hypoglycemic effect with blood glucose value after model group comparative experiments.The high dose group of medicine of the present invention is compared with positive drug group, and blood glucose declines significant difference, illustrates that the effect of medicine of the present invention is better than positive drug.
Claims (5)
1. one kind has the pharmaceutical preparation of effect of lowering blood sugar, it is characterized in that, the active component contained by it is prepared from: Radix Betae 20 parts, Lignum toxicodendri verniciflni 18 parts, Herba kalanchoes spathulatae 20 parts, Herba Thladiantghae verrucosae 15 parts, Radix indigoferae Pseudotinctoriae 20 parts, Radix Polygalae Crotalarioidis 18 parts, Semen Canarii Pimelae 16 parts, Herba Apocyni veneti 14 parts, Semen Pongamiae Pinnatae 18 parts, Radix Campylotropis Delavayi 20 parts by following raw materials in part by weight proportioning.
2. have as claimed in claim 1 and fall hypoglycemic pharmaceutical preparation, it is characterized in that, preparation method comprises the steps: that getting above-mentioned medical material merges, decoct with water twice, collecting decoction, when being concentrated into 65 DEG C, relative density is 1.10-1.20, adds ethanol, stirs, make alcohol content by volume percentage calculation reach 65-85%, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.20-1.30 and reclaims ethanol, by concentrated solution spraying dry, gained granular powder is broken into dry extract, adds adjuvant, makes granule, tablet, capsule.
3. there is pharmaceutical preparation as claimed in claim 2 that reduce blood glucose effect, it is characterized in that, in preparation method, decocting condition is: amount of water is the 8-12 times amount of medical material weight for the first time, decocts 1-2h, second time amount of water is the 6-10 times amount of medical material weight, decocts 1-2h.
4. there is pharmaceutical preparation as claimed in claim 2 that reduce blood glucose effect, it is characterized in that, spray drying condition described in preparation method is: inlet temperature is 90-110 DEG C, leaving air temp is 60-90 DEG C, temperature of charge is 60-90 DEG C, atomizing pressure is 0.2-0.5 MPa, and spray velocity is 1-10ml/s.
5. pharmaceutical preparation as claimed in claim 1 has the application reduced in blood glucose effect medicine in preparation.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105663312A (en) * | 2016-03-04 | 2016-06-15 | 南京多宝生物科技有限公司 | Preparation method and application of red sage root formula granules |
| CN105687257A (en) * | 2016-03-04 | 2016-06-22 | 南京多宝生物科技有限公司 | Poria cocos formula granule preparation method and application |
| CN105748542A (en) * | 2016-03-07 | 2016-07-13 | 南京多宝生物科技有限公司 | Preparation method and application of angelica sinensis formula granules |
Citations (1)
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| CN102614258A (en) * | 2012-04-23 | 2012-08-01 | 卞毓平 | Chinese medicinal composition with blood sugar reducing effect, and preparation method and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102614258A (en) * | 2012-04-23 | 2012-08-01 | 卞毓平 | Chinese medicinal composition with blood sugar reducing effect, and preparation method and application thereof |
Non-Patent Citations (3)
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| 何一成: "《8周改善糖尿病饮食事典》", 30 June 2014, 中国纺织出版社 * |
| 玉山江: "糖尿病从热毒论治探要", 《新疆中医药》 * |
| 郭建辉: "从气机升降异常论治 2 型糖尿病", 《中国中医药信息杂志》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105663312A (en) * | 2016-03-04 | 2016-06-15 | 南京多宝生物科技有限公司 | Preparation method and application of red sage root formula granules |
| CN105687257A (en) * | 2016-03-04 | 2016-06-22 | 南京多宝生物科技有限公司 | Poria cocos formula granule preparation method and application |
| CN105748542A (en) * | 2016-03-07 | 2016-07-13 | 南京多宝生物科技有限公司 | Preparation method and application of angelica sinensis formula granules |
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Application publication date: 20150826 |