CN101700327B - Drug for treating prostatitis and preparation method - Google Patents

Abstract

The invention relates to a preparation method of a traditional Chinese medicine, in particular to a drug for treating prostatitis and a preparation method thereof. The preparation method is that 1600g of herba epimedii, 800g of raidx astragali, 600g of cattail pollen, 800g of plantain and 200g of medicinal cyathula root are used as bulk pharmaceutical chemicals and the preparation method comprises the following steps: taking a defined amount of herba epimedii, raidx astragali, cattail pollen, plantain and medicinal cyathula root to add 2000g of water to perform hot reflux and extraction for 2.5 hours, reducing pressure and concentrating the product into thick paste at the temperature of 60 DEG C, performing vacuum drying at the temperature of 60 DEG C, pulverizing into fine powder, mixing the fine powder with auxiliary materials to prepare capsules. The drug prepared by the invention has high-content effective components; the preparation efficiency and the yield are improved compared with the traditional technology; the effective components are not decomposed in the preparation process; and the content of the effective components are reserved to greatest degree, thus improving the bioavailability of the drug and having obvious advantages compared with the drug prepared by the original method.

Description

Prostatitic medicine of a kind of treatment and preparation method

Technical field

The present invention relates to a kind of Chinese medicinal preparation method, specifically is prostatitic medicine of a kind of treatment and preparation method.

Background technology

In prior art, the medicine of treatment prostatitis disease--prostate disease capsule (standard YBZ05102006) prescription is Herba Epimedii 1600g, Radix Astragali 800g, Pollen Typhae 600g, Herba Plantaginis 800g, Radix Cyathulae 200g.Preparation method is: Herba Epimedii, the Radix Astragali, Pollen Typhae, Herba Plantaginis, the Radix Cyathulae of getting ormal weight add water 2000g, decoct with water secondary, 2 hours for the first time, 1.5 hours for the second time, collecting decoction filtered, filtrate is concentrated into the extractum that relative density is 1.4 (80 ℃ of surveys), and drying is ground into fine powder, add appropriate amount of auxiliary materials, mixing is made granule, dry, encapsulated, make 1000, promptly.The product that this technology obtains is its Main Ingredients and Appearance icariin (C after testing ₃₃H ₄₀O ₁₅) content is the 1.2mg/ grain.Detection method: measure according to high performance liquid chromatography (appendix VID of Chinese Pharmacopoeia version in 2005).This preparation method shortcoming is that the production time is long, and work efficiency is low, and technological temperature is too high, and its active ingredient is easily destroyed, lessens the curative effect.

Summary of the invention

The objective of the invention is provides a kind of technological effect better a kind of preparation method for the treatment of the prostatitis medicine at above-mentioned deficiency.

Technical solution of the present invention is: a kind of method for the treatment of the prostatitis medicine may further comprise the steps:

(1) crude drug is Herba Epimedii 1600g, Radix Astragali 800g, Pollen Typhae 600g, Herba Plantaginis 800g and Radix Cyathulae 200g.

(2) Herba Epimedii, the Radix Astragali, Pollen Typhae, Herba Plantaginis and the Radix Cyathulae of getting ormal weight adds water 2000g hot reflux and extracted 2.5 hours, and 60 ℃ of concentrating under reduced pressure become thick paste, and 60 ℃ of vacuum dryings are ground into fine powder, with auxiliary materials and mixing, make capsule.

Medicine Main Ingredients and Appearance icariin testing result:

Detection method is measured according to high performance liquid chromatography (appendix VID of Chinese Pharmacopoeia version in 2005).

Chromatographic condition and system suitability test are filler with octadecylsilane chemically bonded silica; Acetonitrile-water (25: 75) is a mobile phase; The detection wavelength is 270nm; Number of theoretical plate should be not less than 3000 by the icariin peak.

It is an amount of that the preparation precision of reference substance solution takes by weighing the icariin reference substance, adds methanol and be mixed with the solution that every 1ml contains 55 μ g, promptly.

The content 0.3g under this product content uniformity item is got in the preparation of need testing solution, accurate claims surely, and the accurate 70% ethanol 50ml that adds claims decide weight, and supersound process 30 minutes is put coldly, supplies the weight that subtracts mistake with 70% ethanol, filtration, and filtrate is as need testing solution.

Accurate respectively reference substance solution and each the 10 μ l of need testing solution of drawing of algoscopy inject chromatograph of liquid, measure icariin (C ₃₃H ₄₀O ₁₅) content is the 2.Omg/ grain, promptly.

Two kinds of its Main Ingredients and Appearance icariin of product (C that technology obtains ₃₃H ₄₀O ₁₅) every of content differs the 0.8mg/ grain, bioavailability can improve 66%. this shows process innovation optimization after effect obvious, improved the curative effect of product greatly.

The process choice orthogonal experiments is:

The factor level table

Level	A extraction time	The B thickening temperature	The C bake out temperature
				1	2.5	60	60
2	3	80	80
				3	3.5	100	100

Orthogonal Experiment and Design table and result

Tested number	Extraction time (A)	Thickening temperature (B)	Bake out temperature (C)	Icariin content (x)
					1	1	1	1	2.06
2	1	2	2	2.04
					3	1	3	3	1.31
4	2	1	2	2.03
					5	2	2	3	1.96
6	2	3	1	1.96
					7	3	1	3	1.27
8	3	2	1	1.58
					9	3	3	2	1.21

Select optimum experimental condition to be by result of the test: 2.5 hours extraction times, thickening temperature and bake out temperature are 60 ℃.

Advantage of the present invention is: the effective ingredient content height that the present invention makes, improve work efficiency than traditional handicraft, and improve yield.Active ingredient is not decomposed in the middle of preparation process, and shows that through pharmacodynamic study its medicine effective component content is at utmost kept, thereby has improved bioavailability of medicament.Has remarkable advantages than former method.

Below in conjunction with embodiment embodiments of the present invention are described in further detail.

The specific embodiment

A kind of method for the treatment of the prostatitis medicine may further comprise the steps:

1, used medicine material is Herba Epimedii 1600g, Radix Astragali 800g, Pollen Typhae 600g Herba Plantaginis 800g, Radix Cyathulae 200g.

2, Herba Epimedii, the Radix Astragali, Pollen Typhae, Herba Plantaginis, the Radix Cyathulae of getting ormal weight adds water 2000g hot reflux and extracted 2.5 hours, and 60 ℃ of concentrating under reduced pressure become thick paste, and 60 ℃ of vacuum dryings are ground into fine powder, with suitable auxiliary materials and mixing, make capsule for clinical use.

Claims (1)

1. one kind prepares the method for the treatment of the prostatitis medicine, may further comprise the steps:

(1) crude drug is Herba Epimedii 1600g, Radix Astragali 800g, Pollen Typhae 600g, Herba Plantaginis 800g and Radix Cyathulae 200g;

(2) Herba Epimedii, the Radix Astragali, Pollen Typhae, Herba Plantaginis and the Radix Cyathulae of getting ormal weight adds water 2000g hot reflux and extracted 2.5 hours, and 60 ℃ of concentrating under reduced pressure become thick paste, and 60 ℃ of vacuum dryings are ground into fine powder, with auxiliary materials and mixing, make capsule.