CN103877246A - Medicament capable of nourishing kidneys, promoting blood circulation, relieving rheumatism and pain and strengthening body and brain and preparation method of medicament - Google Patents
Medicament capable of nourishing kidneys, promoting blood circulation, relieving rheumatism and pain and strengthening body and brain and preparation method of medicament Download PDFInfo
- Publication number
- CN103877246A CN103877246A CN201410110176.2A CN201410110176A CN103877246A CN 103877246 A CN103877246 A CN 103877246A CN 201410110176 A CN201410110176 A CN 201410110176A CN 103877246 A CN103877246 A CN 103877246A
- Authority
- CN
- China
- Prior art keywords
- medicament
- ginseng
- preparation
- seudo
- radix
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a preparation method of a traditional Chinese medicine, and particularly relates to medicament capable of nourishing kidneys, promoting blood circulation, relieving rheumatism and pain and strengthening the body and the brain and the preparation method of the medicament. The medicament is prepared from the following raw materials by weight: 204.5g of prepared rehmannia root, 272.8g of polygonum multiflorum, 136.4g of the bark of eucommia, 136.4g of herba pyrolae, 136.4g of rhizoma drynariae (scalded), 100g of uncaria rhynchophylla, 100g of radix puerariae, 50g of pseudo-ginseng and 86.2g of semen raphani (fried). The preparation method comprises the following steps: taking 25g of the seudo-ginseng from the nine raw materials and crushing the seudo-ginseng into fine powder; adding water into the rest seudo-ginseng and the rest eight raw materials including the prepared rehmannia root, wherein the amount of the added water is eight times that of the rest seudo-ginseng and the rest eight raw materials; performing a heat reflux extraction process for 5 hours, filtering, concentrating filtrate into thick paste of which the relative density is 1.30-1.35 (at 80 DEG C) and making the thick paste into 1000 capsules, wherein each capsule contains 0.65mg of the seudo-ginseng, metered based on ginsenoside Rg1 (C42H72O14). The medicament prepared by the method disclosed by the invention has high effective component content, the work efficiency is improved, the yield is increased and the curative effect of a product is improved.
Description
Technical field
The present invention relates to a kind of Chinese medicinal preparation method, specifically a kind of invigorating kidney, promoting blood circulation, numbness relieving and pain relieving, keep fit medicine and the preparation method of brain-strengthening.Trade name: neck recovering capsule (drug standard numbering YBZ11092008).
Background technology
In prior art, neck recovering capsule (drug standard numbering YBZ11092008) is for due to treatment blood stasis due to renal deficiency myelopathy: neck distending pain numbness, movable unfavorable, the medicine of dizziness and tinnitus.Its prescription is: Radix Rehmanniae Preparata 204.5g, Radix Polygoni Multiflori 272.8g, Cortex Eucommiae 136.4g, Herba Pyrolae 136.4g, Rhizoma Drynariae (scalding) 136.4g, Ramulus Uncariae Cum Uncis 100g, Radix Puerariae 100g, Radix Notoginseng 50g, Semen Raphani (stir-fry) 86.2g.Preparation method is: above nine tastes, and get Radix Notoginseng 25g and be ground into fine powder; Eight tastes such as remaining Radix Notoginseng and Radix Rehmanniae Preparata, decoct with water secondary, add for the first time 8 times of water gagings, decoct 3 hours; Add for the second time 8 times of water gagings, decoct 2 hours, collecting decoction, filter, it is 1.30～1.35(80 DEG C that filtrate is concentrated into relative density) thick paste, mix with above-mentioned powder, dry, pulverize into fine powder, add appropriate amount of starch, mix, granulate, dry, incapsulate, make 1000, to obtain final product.The product that this technique obtains after testing every of its Main Ingredients and Appearance contains Radix Notoginseng with ginsenoside Rg
1(C
42h
72o
14) meter, be 0.40mg, assay method is: measure according to high performance liquid chromatography (annex VI D of Chinese Pharmacopoeia version in 2010).This preparation method shortcoming is that the production time is long, and work efficiency is low, and its active ingredient is easily destroyed, lessens the curative effect.
Summary of the invention
The object of the invention is to provide for above-mentioned deficiency a kind of technological effect better a kind of can invigorating kidney, promoting blood circulation, numbness relieving and pain relieving, keep fit medicine and the preparation method of brain-strengthening.
Technical solution of the present invention is: a kind of invigorating kidney, promoting blood circulation, numbness relieving and pain relieving, keep fit the process for preparing medicine of brain-strengthening and comprise the following steps:
(1) raw material is Radix Rehmanniae Preparata 204.5g, Radix Polygoni Multiflori 272.8g, Cortex Eucommiae 136.4g, Herba Pyrolae 136.4g, Rhizoma Drynariae (scalding) 136.4g, Ramulus Uncariae Cum Uncis 100g, Radix Puerariae 100g, Radix Notoginseng 50g, Semen Raphani (stir-fry) 86.2g.
(2) above nine tastes, get Radix Notoginseng 25g and are ground into fine powder.
(3) get the water that remaining Radix Notoginseng and Radix Rehmanniae Preparata, Radix Polygoni Multiflori, the Cortex Eucommiae, Herba Pyrolae, Rhizoma Drynariae (scalding), Ramulus Uncariae Cum Uncis, Radix Puerariae, Semen Raphani (stir-fry) add 8 times of amounts, hot reflux is extracted 5 hours, filter, it is 1.30～1.35(80 DEG C that filtrate is concentrated into relative density) thick paste.
(4) thick paste is mixed with above-mentioned powder, dry, pulverize into fine powder, add appropriate amount of starch, mix, granulate, dry, incapsulate, make 1000, to obtain final product.
Medicine Main Ingredients and Appearance ginsenoside Rg
1(C
42h
72o
14) testing result is: every of this product containing Radix Notoginseng with ginsenoside Rg
1(C
42h
72o
14) meter, content is: 0.65mg/ grain.
Advantage of the present invention: the medicament effective component that the present invention makes is higher than traditional handicraft content, improves work efficiency, improves yield.In the middle of preparation process, active ingredient is not decomposed, and shows through pharmacodynamic study, and its medicament effective component content is at utmost retained, thereby has improved the bioavailability of medicine, has clear superiority than former method, has improved the curative effect of product.
Below in conjunction with embodiment, embodiments of the present invention are described in further detail.
Detailed description of the invention
Embodiment 1
A kind of invigorating kidney, promoting blood circulation, numbness relieving and pain relieving, keep fit the process for preparing medicine of brain-strengthening and comprise the following steps: raw material is Radix Rehmanniae Preparata 204.5g, Radix Polygoni Multiflori 272.8g, Cortex Eucommiae 136.4g, Herba Pyrolae 136.4g, Rhizoma Drynariae (scalding) 136.4g, Ramulus Uncariae Cum Uncis 100g, Radix Puerariae 100g, Radix Notoginseng 50g, Semen Raphani (stir-fry) 86.2g; Above nine tastes, get Radix Notoginseng 25g and are ground into fine powder; Eight tastes such as remaining Radix Notoginseng and Radix Rehmanniae Preparata, add the water of 8 times of amounts, and hot reflux is extracted 5 hours, filter, it is 1.30～1.35(80 DEG C that filtrate is concentrated into relative density) thick paste, mix with above-mentioned powder, dry, pulverize into fine powder, add appropriate amount of starch, mix, granulate, dry, incapsulate, make 1000, to obtain final product.
Experimental example 1
Medicine Main Ingredients and Appearance ginsenoside Rg
1(C
42h
72o
14) detect
Detection method: measure according to high performance liquid chromatography (annex VI D of Chinese Pharmacopoeia version in 2010).
Chromatographic condition and system suitability: taking octadecylsilane chemically bonded silica as filler; Taking acetonitrile-0.05% phosphoric acid solution (20:80) as mobile phase; Detection wavelength is 203nm.Number of theoretical plate is by ginsenoside Rg
1peak calculates should be not less than 2500.
The preparation of reference substance solution: precision takes ginsenoside Rg
1reference substance is appropriate, adds methanol and makes the solution of every 1ml containing 0.2mg, shakes up, and to obtain final product.
The preparation of need testing solution: embodiment 1 product.Get the content under content uniformity item, porphyrize, get 1g, accurately weighed, add water saturated n-butyl alcohol 50ml, close plug, weighed weight, placement is spent the night, supersound process 1 hour, let cool, weighed weight again, supply the weight of less loss with water saturated n-butyl alcohol, shake up, filter, precision measures subsequent filtrate 25ml, the ammonia solution saturated with n-butyl alcohol washs 2 times, each 25ml, cleaning mixture extracts 2 times with water saturated n-butyl alcohol jolting again, each 20ml, merge n-butyl alcohol liquid, evaporate to dryness, residue adds dissolve with methanol and is transferred in 5ml measuring bottle, add methanol to scale, shake up, obtain.
Algoscopy: accurate reference substance solution and the each 10 μ l of need testing solution of drawing respectively, injection liquid chromatography, measures, and to obtain final product.
Every of this product contains Radix Notoginseng with ginsenoside Rg
1(C
42h
72o
14) meter, content is: 0.65mg/ grain.
Experimental example 2
Technological parameter is selected
Process choice Orthogonal experiment results is:
Factor level table
Orthogonal test conceptual design and result
Select optimum experimental condition to be by result of the test: solvent consumption is 8 times of medical material, 5 hours extraction times.The Main Ingredients and Appearance ginsenoside Rg of product under these process conditions
1(C
42h
72o
14) content is the highest.
Two kinds of its Main Ingredients and Appearance of product ginsenoside Rgs that technique obtains
1(C
42h
72o
14) content differs 0.25mg, bioavailability can improve 62.5%, illustrates that active ingredient is not decomposed in the middle of the preparation process of new method, and its medicament effective component content is at utmost retained.
After process innovation optimization, successful shows the curative effect that has greatly improved product as can be seen here.
Claims (1)
- Energy invigorating kidney, promoting blood circulation, numbness relieving and pain relieving, keep fit medicine and the preparation method of brain-strengthening, it is characterized in that step is as follows:(1) raw material is Radix Rehmanniae Preparata 204.5g, Radix Polygoni Multiflori 272.8g, Cortex Eucommiae 136.4g, Herba Pyrolae 136.4g, Rhizoma drynariae preparata 136.4g, Ramulus Uncariae Cum Uncis 100g, Radix Puerariae 100g, Radix Notoginseng 50g, Semen Raphani (parched) 86.2g;(2) above nine tastes, get Radix Notoginseng 25g and are ground into fine powder;(3) eight tastes such as remaining Radix Notoginseng and Radix Rehmanniae Preparata, add the water of 8 times of amounts, and hot reflux is extracted 5 hours, filter, and it is 1.30～1.35 thick paste that filtrate is concentrated into relative density at 80 DEG C;(4) thick paste is mixed with above-mentioned powder, dry, pulverize into fine powder, add starch, mix, granulate, dry, incapsulate, make 1000, to obtain final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410110176.2A CN103877246A (en) | 2014-03-24 | 2014-03-24 | Medicament capable of nourishing kidneys, promoting blood circulation, relieving rheumatism and pain and strengthening body and brain and preparation method of medicament |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410110176.2A CN103877246A (en) | 2014-03-24 | 2014-03-24 | Medicament capable of nourishing kidneys, promoting blood circulation, relieving rheumatism and pain and strengthening body and brain and preparation method of medicament |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103877246A true CN103877246A (en) | 2014-06-25 |
Family
ID=50946582
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410110176.2A Pending CN103877246A (en) | 2014-03-24 | 2014-03-24 | Medicament capable of nourishing kidneys, promoting blood circulation, relieving rheumatism and pain and strengthening body and brain and preparation method of medicament |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103877246A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107126480A (en) * | 2016-02-29 | 2017-09-05 | 山东中泰药业有限公司 | A kind of Chinese medicine capsules and its method of quality control for treating cervical spondylopathy |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101773561A (en) * | 2009-01-13 | 2010-07-14 | 北京亚东生物制药有限公司 | Chinese medicine composition with functions of tonifying kidney, invigorating blood circulation and relieving pain and preparation method thereof |
| CN101953940A (en) * | 2010-10-16 | 2011-01-26 | 秦皇岛皇威制药有限公司 | Traditional Chinese medicine having function of tonifying kidney, invigorating blood circulation and relieving pain, preparation method and quality specification thereof |
-
2014
- 2014-03-24 CN CN201410110176.2A patent/CN103877246A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101773561A (en) * | 2009-01-13 | 2010-07-14 | 北京亚东生物制药有限公司 | Chinese medicine composition with functions of tonifying kidney, invigorating blood circulation and relieving pain and preparation method thereof |
| CN101953940A (en) * | 2010-10-16 | 2011-01-26 | 秦皇岛皇威制药有限公司 | Traditional Chinese medicine having function of tonifying kidney, invigorating blood circulation and relieving pain, preparation method and quality specification thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107126480A (en) * | 2016-02-29 | 2017-09-05 | 山东中泰药业有限公司 | A kind of Chinese medicine capsules and its method of quality control for treating cervical spondylopathy |
| CN107126480B (en) * | 2016-02-29 | 2020-08-07 | 山东中泰药业有限公司 | A Chinese medicinal capsule for treating cervical spondylosis, and its quality control method |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103207255B (en) | A kind of detection method of content of NAOXINTONG JIAONANG | |
| CN102988667B (en) | Preparation method and application of tablet for regulating menstruation and activating blood | |
| CN103720892A (en) | Traditional Chinese medicine composition comprising herba epimedii and preparation method of traditional Chinese medicine composition | |
| CN103800438A (en) | Ligusticum wallichii tea modulator and preparation method thereof | |
| CN103784505B (en) | 'Chuan Xiong Tea ' | |
| CN103784761A (en) | Drug for treatment of vertigo and preparation method thereof | |
| CN102973861A (en) | Preparation method and quality control method of sugar-free compound fructus momordicae antitussive particles | |
| CN103877246A (en) | Medicament capable of nourishing kidneys, promoting blood circulation, relieving rheumatism and pain and strengthening body and brain and preparation method of medicament | |
| CN102590423B (en) | Fingerprint spectrum determination method of ligusticum wallichii tea-blending granular preparation | |
| CN102233097A (en) | Quality control method for Zengguang capsules | |
| CN100515476C (en) | Compound capsule with pseudo-ginseng and Chinese fanpalm seed, its preparation process and quality control method | |
| CN101700327B (en) | Drug for treating prostatitis and preparation method | |
| CN103933295A (en) | Six-ingredient rehmannia pill and preparation technology thereof | |
| CN103816223B (en) | Sugarless type Chuan Xiong Tea particle | |
| CN102743523A (en) | Production process of traditional Chinese medicine for treating anhypnia | |
| CN105456688A (en) | Preparation method of medicinal preparation with efficacies of benefiting qi for activating blood circulation and eliminating fatigue | |
| CN102824487A (en) | Preparation method of weight-reducing capsule | |
| CN102397346B (en) | Method for preparing hepatitis B health-energy-strengthening capsule | |
| CN101869644A (en) | Dark-skinned chicken dispersible tablet and preparation process thereof | |
| CN102178778B (en) | Medicament for tranquilizing mind, invigorating brain, strengthening body and relieving fatigue and preparation method thereof | |
| CN104857143A (en) | Medicinal preparation for improving anoxia endurance | |
| CN104510813A (en) | Preparation method for Xinmaitong capsules | |
| CN108969567B (en) | Preparation method of traditional Chinese medicine composition containing rock fat | |
| CN101829281A (en) | Pharmaceutical composite capsule containing siegesbeckia herba and preparation method thereof | |
| CN103768494B (en) | One treats migrainous pharmaceutical composition and its preparation method and application |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20140625 |