CN104510813A - Preparation method for Xinmaitong capsules - Google Patents
Preparation method for Xinmaitong capsules Download PDFInfo
- Publication number
- CN104510813A CN104510813A CN201510011589.XA CN201510011589A CN104510813A CN 104510813 A CN104510813 A CN 104510813A CN 201510011589 A CN201510011589 A CN 201510011589A CN 104510813 A CN104510813 A CN 104510813A
- Authority
- CN
- China
- Prior art keywords
- radix
- water
- minutes
- filter
- concentrated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002775 capsule Substances 0.000 title claims abstract description 36
- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- 239000008579 xinmaitong Substances 0.000 title abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 76
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 68
- 239000000843 powder Substances 0.000 claims abstract description 56
- 239000000706 filtrate Substances 0.000 claims abstract description 44
- 238000000605 extraction Methods 0.000 claims abstract description 20
- 239000000284 extract Substances 0.000 claims abstract description 15
- 239000006228 supernatant Substances 0.000 claims abstract description 15
- 238000002156 mixing Methods 0.000 claims abstract description 10
- 210000000582 semen Anatomy 0.000 claims abstract description 7
- 235000003143 Panax notoginseng Nutrition 0.000 claims description 31
- 241000180649 Panax notoginseng Species 0.000 claims description 31
- 241000628997 Flos Species 0.000 claims description 20
- 238000004064 recycling Methods 0.000 claims description 14
- 239000012467 final product Substances 0.000 claims description 10
- 230000001476 alcoholic effect Effects 0.000 claims description 9
- 239000003814 drug Substances 0.000 claims description 9
- 239000002671 adjuvant Substances 0.000 claims description 8
- 238000001035 drying Methods 0.000 claims description 6
- 238000010992 reflux Methods 0.000 claims description 6
- 239000012141 concentrate Substances 0.000 claims description 5
- 206010013786 Dry skin Diseases 0.000 claims description 3
- 239000000084 colloidal system Substances 0.000 claims description 3
- 239000007787 solid Substances 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- 239000007788 liquid Substances 0.000 claims description 2
- 238000000034 method Methods 0.000 abstract description 21
- 239000000203 mixture Substances 0.000 abstract description 7
- 244000061520 Angelica archangelica Species 0.000 abstract 3
- 235000011509 Angelica tomentosa Nutrition 0.000 abstract 3
- 244000131316 Panax pseudoginseng Species 0.000 abstract 3
- 235000003181 Panax pseudoginseng Nutrition 0.000 abstract 3
- 244000046101 Sophora japonica Species 0.000 abstract 3
- 235000010586 Sophora japonica Nutrition 0.000 abstract 3
- 241000607122 Uncaria tomentosa Species 0.000 abstract 3
- 235000011472 cat’s claw Nutrition 0.000 abstract 3
- 240000000031 Achyranthes bidentata Species 0.000 abstract 2
- 235000003365 Ilex pubescens Nutrition 0.000 abstract 2
- 241001100932 Ilex pubescens Species 0.000 abstract 2
- 244000179560 Prunella vulgaris Species 0.000 abstract 2
- 235000010674 Prunella vulgaris Nutrition 0.000 abstract 2
- 241000731396 Pueraria montana var. thomsonii Species 0.000 abstract 2
- 241000304195 Salvia miltiorrhiza Species 0.000 abstract 2
- 235000011135 Salvia miltiorrhiza Nutrition 0.000 abstract 2
- 238000001914 filtration Methods 0.000 abstract 1
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 24
- 238000005516 engineering process Methods 0.000 description 22
- 239000006071 cream Substances 0.000 description 21
- 239000000243 solution Substances 0.000 description 17
- 239000008187 granular material Substances 0.000 description 16
- 230000001105 regulatory effect Effects 0.000 description 14
- 235000008733 Citrus aurantifolia Nutrition 0.000 description 12
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 12
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 12
- 229920002472 Starch Polymers 0.000 description 12
- 235000011941 Tilia x europaea Nutrition 0.000 description 12
- 238000009835 boiling Methods 0.000 description 12
- 239000004571 lime Substances 0.000 description 12
- 235000019359 magnesium stearate Nutrition 0.000 description 12
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 12
- 239000008108 microcrystalline cellulose Substances 0.000 description 12
- 229940016286 microcrystalline cellulose Drugs 0.000 description 12
- 235000019698 starch Nutrition 0.000 description 12
- 239000008107 starch Substances 0.000 description 12
- 239000012567 medical material Substances 0.000 description 11
- 229920003139 Eudragit® L 100 Polymers 0.000 description 10
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 10
- 238000004821 distillation Methods 0.000 description 8
- JMGZEFIQIZZSBH-UHFFFAOYSA-N Bioquercetin Natural products CC1OC(OCC(O)C2OC(OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5)C(O)C2O)C(O)C(O)C1O JMGZEFIQIZZSBH-UHFFFAOYSA-N 0.000 description 7
- IVTMALDHFAHOGL-UHFFFAOYSA-N eriodictyol 7-O-rutinoside Natural products OC1C(O)C(O)C(C)OC1OCC1C(O)C(O)C(O)C(OC=2C=C3C(C(C(O)=C(O3)C=3C=C(O)C(O)=CC=3)=O)=C(O)C=2)O1 IVTMALDHFAHOGL-UHFFFAOYSA-N 0.000 description 7
- FDRQPMVGJOQVTL-UHFFFAOYSA-N quercetin rutinoside Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 FDRQPMVGJOQVTL-UHFFFAOYSA-N 0.000 description 7
- IKGXIBQEEMLURG-BKUODXTLSA-N rutin Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@@H]1OC[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-BKUODXTLSA-N 0.000 description 7
- ALABRVAAKCSLSC-UHFFFAOYSA-N rutin Natural products CC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5 ALABRVAAKCSLSC-UHFFFAOYSA-N 0.000 description 7
- 235000005493 rutin Nutrition 0.000 description 7
- 229960004555 rutoside Drugs 0.000 description 7
- 239000002904 solvent Substances 0.000 description 7
- 239000003795 chemical substances by application Substances 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 239000000047 product Substances 0.000 description 6
- 238000004806 packaging method and process Methods 0.000 description 5
- 238000004458 analytical method Methods 0.000 description 4
- 238000002386 leaching Methods 0.000 description 4
- 238000005457 optimization Methods 0.000 description 4
- 239000002244 precipitate Substances 0.000 description 4
- 238000001694 spray drying Methods 0.000 description 4
- 206010020772 Hypertension Diseases 0.000 description 3
- 201000005577 familial hyperlipidemia Diseases 0.000 description 3
- -1 mixing Substances 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- RXUWDKBZZLIASQ-UHFFFAOYSA-N Puerarin Natural products OCC1OC(Oc2c(O)cc(O)c3C(=O)C(=COc23)c4ccc(O)cc4)C(O)C(O)C1O RXUWDKBZZLIASQ-UHFFFAOYSA-N 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 238000007405 data analysis Methods 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- HKEAFJYKMMKDOR-VPRICQMDSA-N puerarin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1C1=C(O)C=CC(C2=O)=C1OC=C2C1=CC=C(O)C=C1 HKEAFJYKMMKDOR-VPRICQMDSA-N 0.000 description 2
- 239000013558 reference substance Substances 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 238000003809 water extraction Methods 0.000 description 2
- 229920000858 Cyclodextrin Polymers 0.000 description 1
- 229960000583 acetic acid Drugs 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000012362 glacial acetic acid Substances 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 238000004811 liquid chromatography Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- YTJSFYQNRXLOIC-UHFFFAOYSA-N octadecylsilane Chemical compound CCCCCCCCCCCCCCCCCC[SiH3] YTJSFYQNRXLOIC-UHFFFAOYSA-N 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 235000019353 potassium silicate Nutrition 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 229940087332 rutin 10 mg Drugs 0.000 description 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000011003 system suitability test Methods 0.000 description 1
- 238000005550 wet granulation Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/482—Cassia, e.g. golden shower tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/536—Prunella or Brunella (selfheal)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a preparation method for Xinmaitong capsules. The method comprises the following steps: 1, crushing pseudo-ginseng, to be specific, crushing pseudo-ginseng into fine powder with granularity of 80 meshes; 2, performing extraction and inclusion on sophora japonica to obtain sophora japonica extract inclusion; 3, extracting angelica and uncaria tomentosa, adding water with the amount which is 8 times of that of angelica and uncaria tomentosa, performing decoction twice for 40 minutes every time, performing concentration to a proper amount, adding ethanol until the ethanol content is 70 percent, performing standing for 24 hours, extracting supernatant for filtration, recovering ethanol from filtrate, and performing concentration to 1.25 to 1.30; 4, extracting salvia miltiorrhiza, pueraria thomsonii, semen cassiae, pubescent holly roots, prunella vulgaris and achyranthes bidentata, to be specific, adding water, and performing decoction twice for 30-60 minutes every time, wherein the amount of water added for the first time is 8 to 12 times of that of the mixture, and the amount of water added for the second time is 8-12 times of that of the mixture; 5, mixing the pseudo-ginseng powder, the sophora japonica extract and inclusion, the extract of angelica and uncaria tomentosa, the extract of salvia miltiorrhiza, pueraria thomsonii, semen cassiae, pubescent holly roots, prunella vulgaris and achyranthes bidentata and auxiliaries, and performing capsulation on the mixture, so as to obtain the Xinmaitong capsules.
Description
Technical field
The present invention relates to a kind of preparation method of heart maitong capsule.Belong to medical art.
Technical background
Heart maitong capsule belongs to prior art, by Radix Angelicae Sinensis, Semen Cassiae, Ramulus Uncariae Cum Uncis, Radix Achyranthis Bidentatae, Radix Salviae Miltiorrhizae, Pachyrhizua angulatus, the Flos Sophorae Immaturus, Radix Ilicis Pubescentis, Spica Prunellae, Radix Notoginseng totally 10 kinds of Chinese crude drugs through being processed into capsule.Have blood circulation promoting and blood stasis dispelling, freeing vessels and nourishing heart, effect of hypertension and hyperlipemia, for hypertension, hyperlipemia etc.Clinical efficacy is remarkable, is widely used.
It is as follows that existing heart maitong capsule is prepared from (consumption is weight portion) heart maitong capsule prescription by following traditional Chinese medicine raw medicine:
More than [method for making] in ten taste medical materials, except Radix Notoginseng powder is broken into fine powder, the Flos Sophorae Immaturus adds after in boiling water, regulates PH to 8.5 with lime cream, decoct secondary, filter, merging filtrate, regulate PH to 4.0 ~ 5.0 with hydrochloric acid, leave standstill 24 hours, leaching precipitates, and dry, pulverize into fine powder, Radix Angelicae Sinensis, Ramulus Uncariae Cum Uncis decoct with water secondary, filter, merging filtrate, be concentrated into appropriate, add ethanol and make alcohol content be 70%, leave standstill 24 hours, get supernatant to filter, filtrate recycling ethanol, is concentrated into thick paste.The Six-elements such as all the other Radix Salviae Miltiorrhizaes decoct with water secondary, and filter, merging filtrate, is concentrated into thick paste.Above-mentioned thick paste and Radix Notoginseng powder, starch, microcrystalline Cellulose, 1% magnesium stearate, Huai Goat fine powder are mixed, makes granule, dry, make 1000 capsules, to obtain final product.
Because existing heart maitong capsule has significant curative effect to treatment hypertension, hyperlipemia, but the content degraded that this product exists, draw the moist problem such as stronger, make this product there is greater risk qualitatively, be unfavorable for the sales promotion of product.
The invention provides a kind of heart maitong capsule new process formula, the technological parameter in original formulation is optimized, the stability of this kind is significantly improved.
Summary of the invention
The object of the present invention is to provide a kind of preparation method of heart maitong capsule.The present invention also aims to bag and technology that a kind of Huai Goat is provided.The present invention also aims to the anti-hygroscopic technology that a kind of capsule is provided.
The preparation method of heart maitong capsule of the present invention, is characterized in that comprising the steps:
1. Radix Notoginseng is pulverized; Pulverized by Radix Notoginseng, obtaining granularity is 80 object fine powders;
2. the Flos Sophorae Immaturus extracts enclose; Obtain Huai Goat clathrate;
3. the extraction of Radix Angelicae Sinensis, Ramulus Uncariae Cum Uncis; Add 8 times amount soak by water secondaries, each 40 minutes, be concentrated into appropriate.Adding ethanol makes alcohol content be 70%, leaves standstill 24 hours, and get supernatant and filter, filtrate recycling ethanol, is concentrated into 1.25-1.30.
4. the extraction of Radix Salviae Miltiorrhizae, Pachyrhizua angulatus, Semen Cassiae, Radix Ilicis Pubescentis, Spica Prunellae, Radix Achyranthis Bidentatae Six-element medicine; Decoct with water secondary, each 30-60 minute, add water 8-12 times amount for the first time, the 2nd the 8-12 times amount that adds water.
5. the extract of the extract of above-mentioned gained Radix Notoginseng medicated powder, Huai Goat clathrate, Radix Angelicae Sinensis, Ramulus Uncariae Cum Uncis and Radix Salviae Miltiorrhizae, Pachyrhizua angulatus, Semen Cassiae, Radix Ilicis Pubescentis, Spica Prunellae, Radix Achyranthis Bidentatae Six-element medicine and adjuvant mixing, encapsulated and get final product.
The Flos Sophorae Immaturus of the present invention extracts, and adopts hot reflux technology to extract, with 8 times amount water extraction 2 times, and each 30 minutes, PH control 8.5, merge extractive liquid, concentrate drying and get final product.
Huai Goat of the present invention, needs to carry out cyclodextrin inclusion compound further.Method is as follows: get beta-schardinger dextrin-100 parts and add appropriate water, add Huai Goat alcoholic solution 10 parts, stirring and dissolving, adopt colloid mill mill certain hour, be cooled to-1 ~ 15 DEG C, filter, obtain solids 30 ~ 40 DEG C of dryings, obtain Huai Goat clathrate.
Therefore, heart maitong capsule of the present invention, the clathrate of Huai Goat just wherein adopted.
Heart maitong capsule prepared by method of the present invention, has excellent technique effect, its technical scheme be through screening obtain, screening process is as follows:
Process optimization is carried out in the extraction of the step 2. Flos Sophorae Immaturus, adopts hot reflux technology.With the rutin rate of transform for inspection target carries out orthogonal experiment by 4 factor 3 levels, experimental result and variance analysis are in table 1, table 2, table 3.
Table 1 affects 4 factor 3 water-glasses that the Flos Sophorae Immaturus extracts
The orthogonal design table that table 2 screens about extraction factor
Table 3 affects the variance analysis of the factor extracting the rate of transform
Visible by analysis, extraction time, quantity of solvent have a significant impact prescription, and can show that Extraction technique combined with extraction time according to average is 30 minutes, and Extraction solvent is water, quantity of solvent is 8 times amount is best collocation, carries out process optimization by this scheme to formula.Owing to have employed hot reflux technology, increase substantially the content rate of transform of medical material, shortened process route, avoid the potential problems that the hydrochloric acid introduced in former technique brings product quality.Therefore optimised process is: adopt hot reflux technology to extract, with 8 times amount water extraction 2 times, and each 30 minutes, PH control 8.5.
Traditional decocting process easily makes medical material local temperature too high, can not complete desorbing, dissolving, diffusion very well.Adopt hot reflux technology, Extraction solvent constantly can carry out desorbing, dissolving, diffusion with medical material, and then reaches the effect fully extracted.This technology is that solvent is added on powder continuously, and from top to bottom by medical material layer, the solutes content in medical material maintains higher gradient, the solute high speed stripping in medical material with solutes content in solvent, until complete stripping, has the advantages that extraction efficiency is high.Extracting solution stops suction concentrator, concentrated indirect steam passes on cooler, concentrate and proceed, until be condensed into extractum, release for subsequent use, due to the stripping of solute high speed, extraction time is short, and concentrated and extraction is carried out simultaneously, and concentrated economic benefits and social benefits of taking concentrate, this technology energy rapid concentration extracting solution, energy savings effectively.Therefore medical material is shorter than traditional time to concentrated ointment, utilization rate of equipment and installations is high.This technical operation, for drop in extraction pot by medical material, adds medical material some water, and open extraction pot and lead directly to and jacket steam valve, after making medicinal material extract certain hour, extracting solution suction concentrator concentrates.The surface that medical material fallen by hot solvent is extracted, and completes a continuous extraction and concentration.
In order to improve the stability of Huai Goat in heart maitong capsule, carry out following preferred process:
Get beta-schardinger dextrin-100 parts and add appropriate water, add Huai Goat alcoholic solution 10 parts, stirring and dissolving, adopt colloid mill mill certain hour, be cooled to-1 ~ 15 DEG C, filter, obtain solids 30 ~ 40 DEG C of dryings, obtain Huai Goat clathrate.In table 4
Huai Goat clathrate preparation table in table 4 heart maitong capsule
According to the balance of material and reasonably apply, with clathrate 5 is the most reasonable.
Investigate the stability of clathrate and non-clathrate
The assay method of rutin content in Huai Goat:
[assay] measures according to high performance liquid chromatography (annex VI D).
Chromatographic condition and system suitability test octadecylsilane chemically bonded silica are filler; With acetonitrile-methanol-water-glacial acetic acid (50:100:350:13) for mobile phase, column temperature 40 DEG C; Determined wavelength 254nm.Theoretical cam curve calculates by rutin, should be not less than 3000.
The preparation precision of reference substance solution takes control substance of Rutin 10mg, puts in 50ml measuring bottle, with a small amount of methanol ultrasonic dissolution, with methanol dilution to scale, shakes up, then draws 2ml and be diluted to 10ml, obtains (1ml is containing rutin 40 μ g).
The content under this product content uniformity item is got in the preparation of need testing solution, and mixing, gets 0.1g, accurately weighed, put in tool plug conical flask, precision adds methanol 50ml, weighed weight, supersound process 30 minutes, lets cool, weighed weight again, supply the weight of less loss with methanol, filter, get subsequent filtrate, filter with microporous filter membrane (0.45 μm), to obtain final product.
Algoscopy is accurate respectively draws reference substance solution and each 10 μ l of need testing solution, injection liquid chromatography, measures, to obtain final product.
Scheme 1: Radix Notoginseng 6 grams is ground into 80 object fine powders, the Flos Sophorae Immaturus 100 grams adds after in 8 times amount boiling water, PH to 8.5 is regulated with lime cream, decoct secondary again, each 30 minutes, filter, merging filtrate, PH to 4.0 ~ 5.0 are regulated with hydrochloric acid, leave standstill 24 hours, leaching precipitates, dry, be ground into fine powder, Radix Angelicae Sinensis 185 grams, Ramulus Uncariae Cum Uncis 125 grams adds 8 times amount soak by water secondaries, each 40 minutes, filter, merging filtrate, be concentrated into appropriate, adding ethanol makes alcohol content be 70%, leave standstill 24 hours, get supernatant to filter, filtrate recycling ethanol, be concentrated into the thick paste of relative density 1.25-1.30.The Six-elements (totally 700 grams) such as all the other Radix Salviae Miltiorrhizaes decoct with water secondary, and filter, merging filtrate, is concentrated into thick paste.Above-mentioned thick paste and Radix Notoginseng powder, starch, microcrystalline Cellulose, 1% magnesium stearate, Huai Goat fine powder are mixed, makes granule, dry, make 1000 capsules.
Scheme 2: Radix Notoginseng 6 grams is ground into 80 object fine powders, the Flos Sophorae Immaturus 100 grams adds after in 8 times amount boiling water, PH to 8.5 is regulated with lime cream, adopt circumfluence distillation technology, decoct secondary again, , each 30 minutes, receive cream, dry, be ground into fine powder, clathrate is prepared in the ratio of 7 parts of Huai Goat and 100 parts of beta-schardinger dextrin-s, Radix Angelicae Sinensis 185 grams, Ramulus Uncariae Cum Uncis 125 grams adds 8 times amount soak by water secondaries, each 40 minutes, filter, merging filtrate, be concentrated into appropriate, adding ethanol makes alcohol content be 70%, leave standstill 24 hours, get supernatant to filter, filtrate recycling ethanol, be concentrated into the thick paste of relative density 1.25-1.30.The Six-elements (totally 700 grams) such as all the other Radix Salviae Miltiorrhizaes decoct with water secondary, and filter, merging filtrate, is concentrated into thick paste.Above-mentioned thick paste and Radix Notoginseng powder, starch, microcrystalline Cellulose, 1% magnesium stearate, Huai Goat clathrate fine powder are mixed, makes granule, dry, make 1000 capsules.
Accelerated stability is investigated and be the results are shown in Table 5
In table 5 heart maitong capsule, the content accelerated stability of 6 months of Huai Goat rutin is investigated
Result shows: effective than direct Huai Goat of the stability of clathrate.Add the stability of rutin content in Huai Goat.
The extraction of the step 4. Six-element medicine such as Radix Salviae Miltiorrhizae carries out process optimization, with the content of puerarin for Testing index, in table 6.
The Six-element medicine extraction processes such as table 6 Radix Salviae Miltiorrhizae are investigated
Draw decoction 2 times by data analysis, each 60 minutes, the mean transferred rate of the content of its puerarin is far above other group.On the multiple of amount of water, 10 times with 8 times group with 12 times and 10 times of groups almost consistent in the content rate of transform, from save energy and reduce the cost angle analysis, as the best: the multiple that adds water is 10 times and 8 times, decocting time 60 minutes/time.Receive cream proportion 1.25-1.30.
Because heart maitong capsule is for being wet granulation, paste containing amount is comparatively large, and granule draws moist stronger.For this situation, carry out and anti-draw moist technology, from step 5., 8. step carry out, and carries out process optimization to draw moist data for reference index.In table 7.
Table 7 draws moist technique investigation table
| Method of granulating | Granule moisture content (%) | Draw moist (%) |
| Standard technology method for making | 4.5 | 11 |
| Standard technology method for making | 3 | 11 |
| Standard technology method for making | 1.5 | 12 |
| Moistureproof coating-Eudragit L100 | 4.5 | 4 |
| Moistureproof coating-Eudragit L100 | 3 | 3 |
| Moistureproof coating-Eudragit L100 | 1.5 | 4 |
| Moistureproof coating-Kollicaot IR | 4.5 | 3 |
| Moistureproof coating-Kollicaot IR | 3 | 4 |
| Moistureproof coating-Kollicaot IR | 1.5 | 3 |
| Spray-drying pelleting machine (Inner adds anti-blushing agent) | 4.5 | 2 |
| Spray-drying pelleting machine (Inner adds anti-blushing agent) | 3 | 1 |
| Spray-drying pelleting machine (Inner adds anti-blushing agent) | 1.5 | 1 |
As can be seen from upper table data: it is moist that moistureproof coating-Eudragit L100 and Kollicaot IR and spray-drying pelleting machine all can effectively reduce drawing of granule, associate without larger with the moisture content of particle drying.From one-tenth originally, used Eudragit L100 more reasonable.But through moistureproof coating granule its draw moist still > 2%, therefore need 8. increase a moisture-proof cover in step, qualified to ensure capsule moisture content before the deadline.As the best, step 5. in charging in total mass percent concentration of clear paste and adjuvant control 16%, and anti-blushing agent is pressed 2% of grain amount, be mixed with the alcoholic solution of 3%, mixing inlet temperature with the mixture of clear paste and adjuvant, to control at air temperature be 175 DEG C, and feed rate controls at 22ml/mim.
Scheme 1: Radix Notoginseng 6 grams is ground into 80 object fine powders, the Flos Sophorae Immaturus 100 grams adds after in 8 times amount boiling water, PH to 8.5 is regulated with lime cream, decoct secondary again, each 30 minutes, filter, merging filtrate, PH to 4.0 ~ 5.0 are regulated with hydrochloric acid, leave standstill 24 hours, leaching precipitates, dry, be ground into fine powder, Radix Angelicae Sinensis 185 grams, Ramulus Uncariae Cum Uncis 125 grams adds 8 times amount soak by water secondaries, each 40 minutes, filter, merging filtrate, be concentrated into appropriate, adding ethanol makes alcohol content be 70%, leave standstill 24 hours, get supernatant to filter, filtrate recycling ethanol, be concentrated into the thick paste of relative density 1.25-1.30.The Six-elements (totally 700 grams) such as all the other Radix Salviae Miltiorrhizaes decoct with water secondary, and filter, merging filtrate, is concentrated into thick paste.Above-mentioned thick paste and Radix Notoginseng powder, starch, microcrystalline Cellulose, 1% magnesium stearate, Huai Goat fine powder are mixed, makes granule, dry, make 1000 capsules.
Scheme 2:: Radix Notoginseng 6 grams is ground into 80 object fine powders, the Flos Sophorae Immaturus 100 grams adds after in 8 times amount boiling water, PH to 8.5 is regulated with lime cream, adopt circumfluence distillation technology, decoct secondary again, each 30 minutes, receive cream, dry, be ground into fine powder, clathrate is prepared in the ratio of 7 parts of Huai Goat and 100 parts of beta-schardinger dextrin-s, Radix Angelicae Sinensis 185 grams, Ramulus Uncariae Cum Uncis 125 grams adds 8 times amount soak by water secondaries, each 40 minutes, filter, merging filtrate, be concentrated into appropriate, adding ethanol makes alcohol content be 70%, leave standstill 24 hours, get supernatant to filter, filtrate recycling ethanol, be concentrated into the thick paste of relative density 1.25-1.30.The Six-elements (totally 700 grams) such as all the other Radix Salviae Miltiorrhizaes decoct with water secondary, each 60 minutes, and add water 10 times amount for the first time, the 2nd 8 times amount that add water, and filter, merging filtrate, is concentrated into the thick paste of relative density 1.25-1.30.By above-mentioned thick paste and Radix Notoginseng powder, starch, microcrystalline Cellulose, 1% magnesium stearate, Huai Goat clathrate fine powder, Eudragit L100 solution, mixing, granulates, dry, makes 1000 capsules.
Scheme 3:: Radix Notoginseng 6 grams is ground into 80 object fine powders, the Flos Sophorae Immaturus 100 grams adds after in 8 times amount boiling water, PH to 8.5 is regulated with lime cream, adopt circumfluence distillation technology, decoct secondary again, each 30 minutes, receive cream, dry, be ground into fine powder, clathrate is prepared in the ratio of 7 parts of Huai Goat and 100 parts of beta-schardinger dextrin-s, Radix Angelicae Sinensis 185 grams, Ramulus Uncariae Cum Uncis 125 grams adds 8 times amount soak by water secondaries, each 40 minutes, filter, merging filtrate, be concentrated into appropriate, adding ethanol makes alcohol content be 70%, leave standstill 24 hours, get supernatant to filter, filtrate recycling ethanol, be concentrated into the thick paste of relative density 1.25-1.30.The Six-elements (totally 700 grams) such as all the other Radix Salviae Miltiorrhizaes decoct with water secondary, each 60 minutes, and add water 10 times amount for the first time, the 2nd 8 times amount that add water, and filter, merging filtrate, is concentrated into the thick paste of relative density 1.25-1.30.By above-mentioned thick paste and Radix Notoginseng powder, starch, microcrystalline Cellulose, 1% magnesium stearate, Huai Goat clathrate fine powder, Eudragit L100 solution, mixing, granulates, dry, makes 1000 capsules.A moisture barrier bag is increased during packaging.
Scheme 4:: Radix Notoginseng 6 grams is ground into 80 object fine powders, the Flos Sophorae Immaturus 100 grams adds after in 8 times amount boiling water, PH to 8.5 is regulated with lime cream, adopt circumfluence distillation technology, decoct secondary again, each 30 minutes, receive cream, dry, be ground into fine powder, clathrate is prepared in the ratio of 7 parts of Huai Goat and 100 parts of beta-schardinger dextrin-s, Radix Angelicae Sinensis 185 grams, Ramulus Uncariae Cum Uncis 125 grams adds 8 times amount soak by water secondaries, each 40 minutes, filter, merging filtrate, be concentrated into appropriate, adding ethanol makes alcohol content be 70%, leave standstill 24 hours, get supernatant to filter, filtrate recycling ethanol, be concentrated into the thick paste of relative density 1.25-1.30.The Six-elements (totally 700 grams) such as all the other Radix Salviae Miltiorrhizaes decoct with water secondary, each 60 minutes, and add water 10 times amount for the first time, the 2nd 8 times amount that add water, and filter, merging filtrate, is concentrated into the thick paste of relative density 1.25-1.30.By above-mentioned thick paste and Radix Notoginseng powder, starch, microcrystalline Cellulose, 1% magnesium stearate, Huai Goat clathrate fine powder, 3%Eudragit L100 alcoholic solution, spray dryer is used to granulate dry, in charging, total mass percent concentration of clear paste and adjuvant controls 16%, and anti-blushing agent is pressed 2% of grain amount, be mixed with the alcoholic solution of 3%, mixing inlet temperature with the mixture of clear paste and adjuvant, to control at air temperature be 175 DEG C, feed rate controls at 22ml/mim, makes 1000 capsules.Accelerated stability is investigated and be the results are shown in Table 8
The accelerated stability data of above-mentioned 4 schemes of table 8
Draw from above-mentioned all data analysiss: the invention has the advantages that: products obtained therefrom oxidation resistance is strong, stability strong, stable curative effect; Integrated artistic is easy to operation, is suitable for applying.
The present invention, by continuing to optimize the technique of prescription, improves the rate of transform of rutin in the Flos Sophorae Immaturus, and adopts inclusion technique to improve the stability of Huai Goat, adopts anti-stability of drawing moist technology raising capsule simultaneously.Curative effect does not reduce simultaneously, and the stability of heart maitong capsule significantly improves.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in further detail.
Embodiment 1: Radix Notoginseng 6 grams is ground into 80 object fine powders, the Flos Sophorae Immaturus 100 grams adds after in 8 times amount boiling water, PH to 8.5 is regulated with lime cream, decoct secondary again, each 30 minutes, filter, merging filtrate, PH to 4.0 ~ 5.0 are regulated with hydrochloric acid, leave standstill 24 hours, leaching precipitates, dry, be ground into fine powder, Radix Angelicae Sinensis 185 grams, Ramulus Uncariae Cum Uncis 125 grams adds 8 times amount soak by water secondaries, each 40 minutes, filter, merging filtrate, be concentrated into appropriate, adding ethanol makes alcohol content be 70%, leave standstill 24 hours, get supernatant to filter, filtrate recycling ethanol, be concentrated into the thick paste of relative density 1.25-1.30.The Six-elements (totally 700 grams) such as all the other Radix Salviae Miltiorrhizaes decoct with water secondary, and filter, merging filtrate, is concentrated into thick paste.Above-mentioned thick paste and Radix Notoginseng powder, starch, microcrystalline Cellulose, 1% magnesium stearate, Huai Goat fine powder are mixed, makes granule, dry, make 1000 capsules.Packaging, to obtain final product.
Embodiment 2: Radix Notoginseng 6 grams is ground into 80 object fine powders, the Flos Sophorae Immaturus 100 grams adds after in 8 times amount boiling water, PH to 8.5 is regulated with lime cream, adopt circumfluence distillation technology, decoct secondary again, each 30 minutes, receive cream, dry, be ground into fine powder, clathrate is prepared in the ratio of 7 parts of Huai Goat and 100 parts of beta-schardinger dextrin-s, Radix Angelicae Sinensis 185 grams, Ramulus Uncariae Cum Uncis 125 grams adds 8 times amount soak by water secondaries, each 40 minutes, filter, merging filtrate, be concentrated into appropriate, adding ethanol makes alcohol content be 70%, leave standstill 24 hours, get supernatant to filter, filtrate recycling ethanol, be concentrated into the thick paste of relative density 1.25-1.30.The Six-elements (totally 700 grams) such as all the other Radix Salviae Miltiorrhizaes decoct with water secondary, and filter, merging filtrate, is concentrated into the thick paste of relative density 1.25-1.30.Above-mentioned thick paste and Radix Notoginseng powder, starch, microcrystalline Cellulose, 1% magnesium stearate, Huai Goat clathrate fine powder are mixed, makes granule, dry, make 1000 capsules.Packaging, to obtain final product.
Embodiment 3: Radix Notoginseng 6 grams is ground into 80 object fine powders, the Flos Sophorae Immaturus 100 grams adds after in 8 times amount boiling water, PH to 8.5 is regulated with lime cream, adopt circumfluence distillation technology, decoct secondary again, each 30 minutes, receive cream, dry, be ground into fine powder, clathrate is prepared in the ratio of 7 parts of Huai Goat and 100 parts of beta-schardinger dextrin-s, Radix Angelicae Sinensis 185 grams, Ramulus Uncariae Cum Uncis 125 grams adds 8 times amount soak by water secondaries, each 40 minutes, filter, merging filtrate, be concentrated into appropriate, adding ethanol makes alcohol content be 70%, leave standstill 24 hours, get supernatant to filter, filtrate recycling ethanol, be concentrated into the thick paste of relative density 1.25-1.30.The Six-elements (totally 700 grams) such as all the other Radix Salviae Miltiorrhizaes decoct with water secondary, each 60 minutes, and add water 10 times amount for the first time, the 2nd 8 times amount that add water, and filter, merging filtrate, is concentrated into thick paste.Above-mentioned thick paste and Radix Notoginseng powder, starch, microcrystalline Cellulose, 1% magnesium stearate, Huai Goat clathrate fine powder are mixed, makes granule, dry, make 1000 capsules.
Embodiment 4: Radix Notoginseng 6 grams is ground into 80 object fine powders, the Flos Sophorae Immaturus 100 grams adds after in 8 times amount boiling water, PH to 8.5 is regulated with lime cream, adopt circumfluence distillation technology, decoct secondary again, each 30 minutes, receive cream, dry, be ground into fine powder, clathrate is prepared in the ratio of 7 parts of Huai Goat and 100 parts of beta-schardinger dextrin-s, Radix Angelicae Sinensis 185 grams, Ramulus Uncariae Cum Uncis 125 grams adds 8 times amount soak by water secondaries, each 40 minutes, filter, merging filtrate, be concentrated into appropriate, adding ethanol makes alcohol content be 70%, leave standstill 24 hours, get supernatant to filter, filtrate recycling ethanol, be concentrated into the thick paste of relative density 1.25-1.30.The Six-elements (totally 700 grams) such as all the other Radix Salviae Miltiorrhizaes decoct with water secondary, each 60 minutes, and add water 10 times amount for the first time, the 2nd 8 times amount that add water, and filter, merging filtrate, is concentrated into the thick paste of relative density 1.25-1.30.By above-mentioned thick paste and Radix Notoginseng powder, starch, microcrystalline Cellulose, 1% magnesium stearate, Huai Goat clathrate fine powder, 3%Eudragit L100 alcoholic solution, mixing, granulates, dry, makes 1000 capsules.Packaging, to obtain final product.
Embodiment 5: Radix Notoginseng 6 grams is ground into 80 object fine powders, the Flos Sophorae Immaturus 100 grams adds after in 8 times amount boiling water, PH to 8.5 is regulated with lime cream, adopt circumfluence distillation technology, decoct secondary again, each 30 minutes, receive cream, dry, be ground into fine powder, clathrate is prepared in the ratio of 7 parts of Huai Goat and 100 parts of beta-schardinger dextrin-s, Radix Angelicae Sinensis 185 grams, Ramulus Uncariae Cum Uncis 125 grams adds 8 times amount soak by water secondaries, each 40 minutes, filter, merging filtrate, be concentrated into appropriate, adding ethanol makes alcohol content be 70%, leave standstill 24 hours, get supernatant to filter, filtrate recycling ethanol, be concentrated into the thick paste of relative density 1.25-1.30.The Six-elements (totally 700 grams) such as all the other Radix Salviae Miltiorrhizaes decoct with water secondary, each 60 minutes, and add water 10 times amount for the first time, the 2nd 8 times amount that add water, and filter, merging filtrate, is concentrated into the thick paste of relative density 1.25-1.30.By above-mentioned thick paste and Radix Notoginseng powder, starch, microcrystalline Cellulose, 1% magnesium stearate, Huai Goat clathrate fine powder, 3%Eudragit L100 alcoholic solution, spray dryer is used to granulate dry, in charging, total mass percent concentration of clear paste and adjuvant controls 16%, and anti-blushing agent is pressed 2% of grain amount, be mixed with the alcoholic solution of 3%, mixing inlet temperature with the mixture of clear paste and adjuvant, to control at air temperature be 175 DEG C, feed rate controls at 22ml/mim, makes 1000 capsules.Packaging, to obtain final product.
Claims (1)
1. a preparation method for heart maitong capsule, is characterized in that comprising the steps:
1. Radix Notoginseng is pulverized; Pulverized by Radix Notoginseng, obtaining granularity is 80 object fine powders;
2. the Flos Sophorae Immaturus extracts enclose; Obtain Huai Goat clathrate;
3. the extraction of Radix Angelicae Sinensis, Ramulus Uncariae Cum Uncis; Add 8 times amount soak by water secondaries, each 40 minutes, be concentrated into appropriate.Adding ethanol makes alcohol content be 70%, leaves standstill 24 hours, and get supernatant and filter, filtrate recycling ethanol, is concentrated into 1.25-1.30.
4. the extraction of Radix Salviae Miltiorrhizae, Pachyrhizua angulatus, Semen Cassiae, Radix Ilicis Pubescentis, Spica Prunellae, Radix Achyranthis Bidentatae Six-element medicine; Decoct with water secondary, each 30-60 minute, add water 8-12 times amount for the first time, the 2nd the 8-12 times amount that adds water.
5. the extract of the extract of above-mentioned gained Radix Notoginseng medicated powder, Huai Goat clathrate, Radix Angelicae Sinensis, Ramulus Uncariae Cum Uncis and Radix Salviae Miltiorrhizae, Pachyrhizua angulatus, Semen Cassiae, Radix Ilicis Pubescentis, Spica Prunellae, Radix Achyranthis Bidentatae Six-element medicine and adjuvant mixing, encapsulated and get final product.
Wherein, the described Flos Sophorae Immaturus extracts enclose, and step is as follows: by 8 times of water gaging reflux, extract, 2 times, each 30 minutes, PH controlled 8.5, merge extractive liquid, concentrate drying, get beta-schardinger dextrin-100 parts and add water, add the alcoholic solution 10 parts of Huai Goat, stirring and dissolving, employing colloid mill grinds, be cooled to-1 ~ 15 DEG C, filter, obtain solids, 30 ~ 40 DEG C of dryings, obtain Huai Goat clathrate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510011589.XA CN104510813B (en) | 2015-01-10 | 2015-01-10 | A kind of preparation method of heart maitong capsule |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510011589.XA CN104510813B (en) | 2015-01-10 | 2015-01-10 | A kind of preparation method of heart maitong capsule |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104510813A true CN104510813A (en) | 2015-04-15 |
| CN104510813B CN104510813B (en) | 2017-09-15 |
Family
ID=52787052
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510011589.XA Active CN104510813B (en) | 2015-01-10 | 2015-01-10 | A kind of preparation method of heart maitong capsule |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104510813B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113599363A (en) * | 2021-08-24 | 2021-11-05 | 江西济民可信药业有限公司 | Preparation method of Xinmaitong capsules |
| CN115487225A (en) * | 2022-09-21 | 2022-12-20 | 江西济民可信药业有限公司 | Preparation method of sophora flower bud extract |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1362223A (en) * | 2001-01-08 | 2002-08-07 | 杨孟君 | Nano Xinmaitong medicine and its preparation |
| CN1376491A (en) * | 2002-04-15 | 2002-10-30 | 徐国勇 | Medicine for treating myocardial infarction and angina pectoris |
| CN1785293A (en) * | 2005-10-17 | 2006-06-14 | 贵州益佰制药股份有限公司 | Quality control method of heart pulse free flow oral preparation |
| CN1823959A (en) * | 2005-12-12 | 2006-08-30 | 湛江市国基药业有限公司 | Heart vessel free flowing dispersion tablet and its preparation method |
| CN101468087A (en) * | 2007-12-26 | 2009-07-01 | 上海玉森新药开发有限公司 | Method for preparing 'Xinmaitong' granular formulation |
-
2015
- 2015-01-10 CN CN201510011589.XA patent/CN104510813B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1362223A (en) * | 2001-01-08 | 2002-08-07 | 杨孟君 | Nano Xinmaitong medicine and its preparation |
| CN1376491A (en) * | 2002-04-15 | 2002-10-30 | 徐国勇 | Medicine for treating myocardial infarction and angina pectoris |
| CN1785293A (en) * | 2005-10-17 | 2006-06-14 | 贵州益佰制药股份有限公司 | Quality control method of heart pulse free flow oral preparation |
| CN1823959A (en) * | 2005-12-12 | 2006-08-30 | 湛江市国基药业有限公司 | Heart vessel free flowing dispersion tablet and its preparation method |
| CN101468087A (en) * | 2007-12-26 | 2009-07-01 | 上海玉森新药开发有限公司 | Method for preparing 'Xinmaitong' granular formulation |
Non-Patent Citations (2)
| Title |
|---|
| 刘锡钧主编: "《福建省基本医疗保险药品实用指南》", 31 March 2002 * |
| 邵伟等: "芦丁-β-环糊精包合物的研究", 《中药材》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113599363A (en) * | 2021-08-24 | 2021-11-05 | 江西济民可信药业有限公司 | Preparation method of Xinmaitong capsules |
| CN113599363B (en) * | 2021-08-24 | 2022-11-11 | 江西济民可信药业有限公司 | Preparation method of Xinmaitong capsules |
| CN115487225A (en) * | 2022-09-21 | 2022-12-20 | 江西济民可信药业有限公司 | Preparation method of sophora flower bud extract |
| CN115487225B (en) * | 2022-09-21 | 2024-02-02 | 江西济民可信药业有限公司 | Preparation method of pagodatree flower bud extract |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104510813B (en) | 2017-09-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102579667B (en) | Preparation method of donkey-hide gelatin and Angelica blood-nourishing particles | |
| CN113599363B (en) | Preparation method of Xinmaitong capsules | |
| CN103784505B (en) | 'Chuan Xiong Tea ' | |
| CN104510813A (en) | Preparation method for Xinmaitong capsules | |
| CN107496375A (en) | A kind of preparation method of herbal mixture granule | |
| CN101647905B (en) | Preparation method of influenze granule for children | |
| CN103830292A (en) | Apocynum flavonoid extract and preparation method thereof | |
| CN104224867B (en) | A kind of desmodium sugar-free particle and preparation method thereof | |
| CN102614240B (en) | Extract containing breviscapine and preparation method thereof | |
| CN102319358B (en) | Preparation method of kidney-tonifying and life-prolonging capsule | |
| CN102048991B (en) | Sugar-reducing comfort pill and preparation method thereof | |
| CN111317789A (en) | Kidney recovering capsule and its prepn | |
| CN107961321B (en) | Extraction process of liuhe pill raw material medicine | |
| CN102590423B (en) | Fingerprint spectrum determination method of ligusticum wallichii tea-blending granular preparation | |
| CN101700327B (en) | Drug for treating prostatitis and preparation method | |
| CN101732527A (en) | Quality detection method for liver-soothing granules | |
| CN103830490A (en) | Extraction method of selenium-rich Huai rhizoma dioscoreae extract | |
| CN101869644B (en) | Dark-skinned chicken dispersible tablet and preparation process thereof | |
| CN103816223B (en) | Sugarless type Chuan Xiong Tea particle | |
| CN104069140B (en) | A kind of method for preparing desmodium medicinal extract and its particle | |
| CN102319308B (en) | Preparation method of heat-clearing cough-relieving oral liquid for children | |
| CN101632747A (en) | Preparation technology of children cold relaxation grain | |
| CN103063793A (en) | Method for determining content of cynomorium songaricum kidney-tonifying capsule | |
| CN103877246A (en) | Medicament capable of nourishing kidneys, promoting blood circulation, relieving rheumatism and pain and strengthening body and brain and preparation method of medicament | |
| CN106563115A (en) | Herba leonuri biochemical mixture and preparation process |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CP01 | Change in the name or title of a patent holder | ||
| CP01 | Change in the name or title of a patent holder |
Address after: 336000 Yuanzhou pharmaceutical industry park, Jiangxi, Yichun Co-patentee after: Jiangxi Jinshuibao Pharmaceutical Co.,Ltd. Patentee after: JIANGXI JIMINKEXIN PHARMACEUTICAL Co.,Ltd. Address before: 336000 Yuanzhou pharmaceutical industry park, Jiangxi, Yichun Co-patentee before: JIANGXI JIMINKEXIN JINSHUIBAO PHARMACEUTICAL Co.,Ltd. Patentee before: JIANGXI JIMINKEXIN PHARMACEUTICAL Co.,Ltd. |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: A preparation method of Xinmaitong capsule Effective date of registration: 20211224 Granted publication date: 20170915 Pledgee: Bank of China Limited Nanchang Qingyunpu sub branch Pledgor: Jiangxi Jinshuibao Pharmaceutical Co.,Ltd. Registration number: Y2021980016165 |
|
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20220902 Granted publication date: 20170915 Pledgee: Bank of China Limited Nanchang Qingyunpu sub branch Pledgor: Jiangxi Jinshuibao Pharmaceutical Co.,Ltd. Registration number: Y2021980016165 |
|
| PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: A kind of preparation method of Xinmaitong capsule Effective date of registration: 20220905 Granted publication date: 20170915 Pledgee: Bank of China Limited Nanchang Qingyunpu sub branch Pledgor: Jiangxi Jinshuibao Pharmaceutical Co.,Ltd. Registration number: Y2022980014590 |
|
| PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20230830 Granted publication date: 20170915 Pledgee: Bank of China Limited Nanchang Qingyunpu sub branch Pledgor: Jiangxi Jinshuibao Pharmaceutical Co.,Ltd. Registration number: Y2022980014590 |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: A preparation method for Xinmaitong capsules Effective date of registration: 20230831 Granted publication date: 20170915 Pledgee: Bank of China Limited Nanchang Qingyunpu sub branch Pledgor: Jiangxi Jinshuibao Pharmaceutical Co.,Ltd. Registration number: Y2023980054963 |
|
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Granted publication date: 20170915 Pledgee: Bank of China Limited Nanchang Qingyunpu sub branch Pledgor: Jiangxi Jinshuibao Pharmaceutical Co.,Ltd. Registration number: Y2023980054963 |