CN105079134A - Preparation process of traditional Chinese medicine preparation used for treating cold and application of traditional Chinese medicine preparation - Google Patents
Preparation process of traditional Chinese medicine preparation used for treating cold and application of traditional Chinese medicine preparation Download PDFInfo
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Abstract
The invention discloses a preparation process of a traditional Chinese medicine preparation used for treating cold and application of the traditional Chinese medicine preparation. The traditional Chinese medicine preparation is composed of honeysuckle, red peony root and male fern rhizome. Active ingredients in three Chinese medicinal herbs are extracted through decocting in water, a clarifying agent and a clarifying agent pretreating agent are used to perform impurity removal on extract, and pharmaceutically feasible excipients are added after the extract is concentrated to be clear paste to prepare the traditional Chinese medicine preparation having efficacy of clearing heat and detoxifying; the traditional Chinese medicine preparation has obvious curative effect on fever, headache, nasal obstruction, sneezing and pharyngalgia caused by exogenous wind-heat.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicine preparation, particularly a kind of preparation technology and application thereof for the treatment of the Chinese medicine composition of flu.
Background technology
Flu, be a kind of self-healing property disease, clinical manifestation is its feature with nasal obstruction, cough, headache, fever with aversion to cold, general malaise, and the whole year all can fall ill.Common cold is divided into again common cold and influenza clinically.Common cold, the traditional Chinese medical science claims " cold ", is a kind of respiratory tract commonly encountered diseases caused by multiple virus.Influenza is the Acute respiratory infectious disease caused by influenza virus.At present, the medicine great majority being used for the treatment of flu are on the market all Western medicine, and Western medicine can only be applied to cold symptoms occur after alleviation, for multiple viral influenza, effect is undesirable, and toxic and side effects is large.
And in the product of in use patent medicine treatment flu, wherein comparitive study significantly has KANGKAN KELI, its constituent is Flos Lonicerae, Radix Paeoniae Rubra, Rhizoma Dryopteris Crassirhizomatis, and preparation technology is conventional decoction and alcohol sedimentation technique, and technological deficiency is wherein: owing to containing a large amount of starch in component Radix Paeoniae Rubra, content of starch in extracting solution is increased, filtration difficulty, the extractum viscosity after concentrated is large, increases the difficulty of granulation, the easy moisture absorption of the granule made, adds investment of production cost.
Summary of the invention
For above-mentioned technological deficiency, in the extracting solution particularly in anti-sense prescription preparation technology, content of starch is high, filtration difficulty, viscosity is large, granulate difficult, the defect of the easy moisture absorption of granule, the object of the present invention is to provide a kind of preparation method being used for the treatment of the Chinese medicine preparation of flu.
The present invention also aims to the application that a kind of above-mentioned Chinese medicine preparation is provided.
A kind of Chinese medicine preparation being used for the treatment of flu described in the present invention, comprises the component of following weight portion:
Flos Lonicerae 700 parts of Radix Paeoniae Rubra 700 parts of Rhizoma Dryopteris Crassirhizomatiss 233 parts
A kind of preparation method being used for the treatment of the Chinese medicine preparation of flu of the present invention is achieved through the following technical solutions: 1. one kind is used for the treatment of the preparation method of the Chinese medicine preparation of flu, it is characterized in that, comprise the steps: extracting honeysuckle 700 parts, Radix Paeoniae Rubra 700 parts, Rhizoma Dryopteris Crassirhizomatis 233 parts, after medical material pre-treatment, soak, add 4-10 times of soak by water, merge extractive liquid, filter, add natural clarifying agent pretreating agent after concentrated to stir, boil, then add natural clarifying agent to boil, let cool, room temperature leaves standstill, get the clear paste that supernatant concentration to relative density is 1.3-1.35 (75 DEG C), described clear paste mixes with the ratio of adjuvant in 1:4 ~ 1:6, adds adjuvant and makes granule, dry, to obtain final product.
2. preparation method according to claim 1, is characterized in that, comprises the steps:
(1) get the Flos Lonicerae of recipe quantity, Radix Paeoniae Rubra, Rhizoma Dryopteris Crassirhizomatis, respectively after pre-treatment, add Aqua pure extract 2-3 time, each amount of water is 4-10 times of crude drug, and merge extractive liquid, filters, after filtrate reduced in volume, add ZTC1+1 natural clarifying agent pretreating agent A and stir, boil; Fluid temperature is cooled to the 50-80 DEG C of ZTC1+1 natural clarifying agent pretreating agent B adding equivalent to stir, insulation, boils, after add ZTC1+1 natural clarifying agent B and stir, insulation; Add ZTC1+1 natural clarifying agent A to stir, boil, let cool, room temperature places about 8-15 hour, high speed centrifugation, and supernatant is evaporated to the clear paste that relative density is 1.3-1.35 (75 DEG C);
(2) clear paste described in step (1) is mixed with the ratio of adjuvant in 1:4 ~ 1:6, add adjuvant and make granule, dry, to obtain final product.
Preparation method of the present invention can be following steps:
(1) get the Flos Lonicerae of recipe quantity, Radix Paeoniae Rubra, Rhizoma Dryopteris Crassirhizomatis, add Aqua pure extract 2-3 time, each 1-2 hour, amount of water is 4-10 times of crude drug.Collecting decoction, filter, filtrate reduced in volume is to certain volume, and the ZTC1+1 natural clarifying agent pretreating agent A adding the 0.2%-1% of crude drug stirs, and boils; Fluid temperature is cooled to the 50-80 DEG C of ZTC1+1 natural clarifying agent pretreating agent B adding equivalent to stir, insulation 5-7 hour, boil 10-30 minute, the 2-10%ZTC1+1 natural clarifying agent B adding medicine liquid volume after fluid temperature drops to 60-80 DEG C stirs, and is incubated 20 minutes; The ZTC1+1 natural clarifying agent A adding the 2%-8% of medicine liquid volume stirs, and boils 30-60 minute.Let cool, room temperature places about 8-15 hour, high speed centrifugation, and supernatant is evaporated to the clear paste that relative density is 1.3-1.35.
(2) clear paste described in step (1) is mixed with the ratio of adjuvant in 1:4 ~ 6, add adjuvant and make granule, dry, to obtain final product.
ZTC1+1 natural clarifying agent described in step (1) is ZTC1+1 II type, the one in ZTC1+1 III type.
Adjuvant described in step (2) is cane sugar powder and dextrin, wherein cane sugar powder: dextrin=50 ~ 60:1.
Granule described in the present invention has effect of heat-clearing and toxic substances removing, and for the heating that affection due to external wind and heat causes, headache, nasal obstruction, sneeze, pharyngalgia has obvious curative effect.
Compared with prior art, the beneficial effect had is in the present invention:
1. compare in traditional alcohol precipitation process after using clarifier and clarifier pre-treatment treatment and easily granulate and the granule made not easily moisture absorption caking, granule soak is limpid;
2., while paste-forming rate is higher than alcohol precipitation process, granule prepared after mixing with less pharmaceutically feasible adjuvant meets pharmacopeia 2010 editions to KANGKAN KELI
The regulation of middle paeoniflorin content, overall economic efficiency considers that technical solutions according to the invention improve output under the prerequisite ensureing granular mass, has saved production cost.
3., compared with traditional alcohol precipitating method, the loss of Dryocrassine reduces the content namely finally staying the Dryocrassine in finished product and increases, and adds productivity effect, reduces cost.
Detailed description of the invention
1. material and instrument:
Medical material: Flos Lonicerae Radix Paeoniae Rubra Rhizoma Dryopteris Crassirhizomatis is purchased from Chinese crude drug wholesale market, International trade city, Chengdu
Reagent: be analytical pure methanol (Chengdu Ke Long chemical reagent factory); Peoniflorin reference substance (middle inspection institute lot number: 110736200527); Dryocrassine reference substance (Institute of Analysis of Sichuan University provides, purity 98%)
ZTC1+1 natural clarifying agent pretreating agent (Tianjin Zheng Tiancheng clarification technique company limited)
ZTC1+1 natural clarifying agent (Tianjin Zheng Tiancheng clarification technique company limited)
Instrument: Agilent 1200 high performance liquid chromatograph
2. the preparation of clarifier:
2.1ZTC1+1 natural clarifying agent (Tianjin Zheng Tiancheng clarification technique company limited) is the polymer substance extracted from food
2.2 preparations:
Component A: first become pasty state by a small amount of deionized water and stirring, then add requirement deionized water, swelling 24 hours, stirs, filters, obtain 1% viscose solution with double gauze.
B component: first with the acetum of glacial acetic acid and deionized water preparation 1%, then stir into pasty state by 1% a small amount of acetate dissolution B component, add 1% acetic acid of q.s, swelling 24 hours, stir, filter with double gauze, obtain 1% viscose solution.
3. paeoniflorin content measures
3.1 reference substance solution preparations: precision takes peoniflorin reference substance 1.57mg 20% methanol constant volume to 10ml product solution in contrast
3.2 sample preparations:
Get the filtrate 2ml pure water after clarification and be settled to 25ml as test sample 1;
Get the finished granule made to pulverize, precision takes 0.6g, puts in tool plug conical flask, precision adds methanol 50ml, weighed weight, supersound process 10 minutes, let cool, weigh, supply minimizing weight with methanol, shake up, leave standstill, precision measures supernatant 10ml, evaporate to dryness, residue 20% dissolve with methanol, adds 20% methanol to 10ml, shake up, centrifugally namely obtain test sample 2.
3.3 paeoniflorin contents measure: measure with reference to 2010 editions pharmacopeia KANGKAN KELI peoniflorin assay method.4. the assay of Dryocrassine
The drafting of 4.1 standard curves: it is appropriate that precision takes Dryocrassine reference substance, and making concentration with chloroform is 0.198mg.ml
-1reference substance solution, sample introduction 2 μ l, 4 μ l, 6 μ l, 8 μ l, 10 μ l respectively, with acetonitrile-chloroform-isopropanol-0.3% phosphoric acid-0.1% sodium lauryl sulphate (50:10:35:10:5) for mobile phase, 286nm is determined wavelength, utilizes high performance liquid chromatograph to measure.Carry out linear regression with the peak area y of gained Dryocrassine to sample size x (μ g), regression equation is: y=1E+06x-10839, R=0.9999; Result shows, Dryocrassine sample size is good in 0.396-1.98ug internal linear relation in scope.
Dryocrassine assay in 4.2 samples: get the finished granule made and grind, take 0.6g, put in tool plug conical flask, precision adds people's chloroform 40mL, and close plug, weighs, and supersound extraction 30min lets cool, then weighs, and supplies the quality of less loss, shake up with chloroform.Filter, get subsequent filtrate 5mL in 10mL measuring bottle, add chloroform and be settled to scale, shake up, microporous filter, get supernatant, sample size is 10 μ l.Measure chromatographic condition consistent with the chromatographic condition of preparation standard curve, obtain the content of Dryocrassine in finished particle.
Embodiment 1:
Take Flos Lonicerae 7000g, Radix Paeoniae Rubra 7000g, Rhizoma Dryopteris Crassirhizomatis 2330g, Aqua pure extract is added 3 times by after three taste medical material coarse crushing process, extraction time is respectively 2 hours, 1.5 hours, 1 hour, amount of water is respectively 10 times, 10 times, 8 times, merge three decoction liquor, filter, filtrate reduced in volume (70 DEG C) is to about 8L, the 0.2%ZTC1+1 natural clarifying agent pretreating agent A adding crude drug total amount stirs, and boils 20 minutes; Fluid temperature is cooled to about 60 DEG C of ZTC1+1 natural clarifying agent pretreating agent B adding equivalent to stir, 60 DEG C of insulations about 6 hours, boil 30 minutes, treat that fluid temperature is down to 70 DEG C and is added 6%ZTC1+1 natural clarifying agent II B and stir, be incubated 20 minutes; Add 2%ZTC1+1 natural clarifying agent II A to stir, boil 1 hour.Let cool, room temperature places about 10h, filters, be evaporated to the clear paste that relative density is 1.33 (75 DEG C), granule made by the adjuvant (cane sugar powder: dextrin=50:1) adding 4 times of clear paste, dry, make granule and be about 17595g, pack, every bag of 10g.
Embodiment 2:
Take Flos Lonicerae 7000g, Radix Paeoniae Rubra 7000g, Rhizoma Dryopteris Crassirhizomatis 2330g, Aqua pure extract is added 3 times by after three taste medical material coarse crushing process, extraction time is respectively 2 hours, 1.5 hours, 1 hour, amount of water is respectively 10 times, 10 times, 8 times, merge three decoction liquor, filter, filtrate reduced in volume (70 DEG C) is to about 8.3L, the 0.2%ZTC1+1 natural clarifying agent pretreating agent A adding crude drug total amount stirs, and boils 20 minutes; Fluid temperature is cooled to about 60 DEG C of ZTC1+1 natural clarifying agent pretreating agent B adding equivalent to stir, 60 DEG C of insulations about 6 hours, boil 30 minutes, treat that fluid temperature is down to 70 DEG C and is added 6%ZTC1+1 natural clarifying agent III B and stir, be incubated 20 minutes; Add 2%ZTC1+1 natural clarifying agent III A to stir, boil 1 hour.Let cool, room temperature places about 10h, filters, be evaporated to the clear paste that relative density is 1.32 (75 DEG C), granule made by the adjuvant (cane sugar powder: dextrin=50:1) adding 4 times of clear paste, dry, make granule and be about 16002g, pack, every bag of 10g.
Embodiment 3:
Take Flos Lonicerae 700g, Radix Paeoniae Rubra 700g, Rhizoma Dryopteris Crassirhizomatis 233g, add Aqua pure extract 2 times by after three taste medical material coarse crushing process, extraction time is respectively 2 hours, 1.5 hours, amount of water was respectively 10 times, 4 times, merged secondary decoction liquor, filter, filtrate reduced in volume (70 DEG C) is to about 10L, and the 1%ZTC1+1 natural clarifying agent pretreating agent A adding crude drug total amount stirs, and boils 10 minutes; Fluid temperature is cooled to about 50 DEG C of ZTC1+1 natural clarifying agent pretreating agent B adding equivalent to stir, 50 DEG C of insulations about 7 hours, boil 10 minutes, treat that fluid temperature is down to 60 DEG C and is added 3%ZTC1+1 natural clarifying agent II B and stir, be incubated 20 minutes; Add 1%ZTC1+1 natural clarifying agent II A to stir, boil 30 minutes.Let cool, room temperature places about 15h, filters, be evaporated to the clear paste that relative density is 1.35 (75 DEG C), granule made by the 5 times amount adjuvants (cane sugar powder: dextrin=60:1) adding clear paste, dry, make granule and be about 1554g, pack, every bag of 10g.
Embodiment 4:
Take Flos Lonicerae 2100g, Radix Paeoniae Rubra 2100g, Rhizoma Dryopteris Crassirhizomatis 699g, add Aqua pure extract 3 times by after three taste medical material coarse crushing process, extraction time is respectively 1.5 hours, amount of water is respectively 10 times, 10 times, 8 times, merge three decoction liquor, filter, filtrate reduced in volume (70 DEG C) is to about 13L, the 0.5%ZTC1+1 natural clarifying agent pretreating agent A adding crude drug total amount stirs, and boils 20 minutes; Fluid temperature is cooled to about 80 DEG C of ZTC1+1 natural clarifying agent pretreating agent B adding equivalent to stir, is incubated about 5 hours, boils 30 minutes, treat that fluid temperature is down to 80 DEG C and is added 10%ZTC1+1 natural clarifying agent III B and stir, be incubated 30 minutes; Add 3%ZTC1+1 natural clarifying agent III A to stir, boil 40 minutes.Let cool, room temperature places about 8h, filters, be evaporated to the clear paste that relative density is 1.31 (75 DEG C), granule made by the 4 times amount adjuvants (cane sugar powder: dextrin=60:1) adding clear paste, dry, make granule and be about 4869g, pack, every bag of 10g.
Embodiment 5:
Take Flos Lonicerae 7000g, Radix Paeoniae Rubra 7000g, Rhizoma Dryopteris Crassirhizomatis 2330g, add Aqua pure extract 3 times by after three taste medical material coarse crushing process, extraction time is respectively 2 hours, 1.5 hours, 1 hour, amount of water is respectively 10 times, 10 times, 8 times, merges three decoction liquor, filters, filtrate reduced in volume (70 DEG C) is to about 163L, after heating concentrated solution to 70 DEG C, 6%ZTC1+1 natural clarifying agent II B adding medicine liquid volume stirs, and is incubated 20 minutes; Add 2%ZTC1+1 natural clarifying agent II A to stir, boil 1 hour.Let cool, room temperature places about 10h, filters, be evaporated to the clear paste that relative density is 1.32 (75 DEG C), granule made by the adjuvant (cane sugar powder: dextrin=50:1) adding 4 times of clear paste, dry, make granule and be about 19204g, pack, every bag of 10g.
Embodiment 6:
Take Flos Lonicerae 1400g, Radix Paeoniae Rubra 1400g, Rhizoma Dryopteris Crassirhizomatis 466g, add Aqua pure extract 3 times by after three taste medical material coarse crushing process, extraction time is respectively 2 hours, 1.5 hours, 1 hour, amount of water is respectively 10 times, 10 times, 8 times, merges three decoction liquor, filters, filtrate reduced in volume (70 DEG C) is to about 150L, after heating concentrated solution to 70 DEG C, 6%ZTC1+1 natural clarifying agent III B adding medicine liquid volume stirs, and is incubated 20 minutes; Add 2%ZTC1+1 natural clarifying agent III A to stir, boil 1 hour.Let cool, room temperature places about 10h, filters, be evaporated to the clear paste that relative density is 1.33 (75 DEG C), granule made by the adjuvant (cane sugar powder: dextrin=50:1) adding 4 times of clear paste, dry, make granule and be about 3520g, pack, every bag of 10g.
Embodiment 7:
Take Flos Lonicerae 700g, Radix Paeoniae Rubra 700g, Rhizoma Dryopteris Crassirhizomatis 233g, add Aqua pure extract 3 times, extraction time is respectively 2 hours, 1.5 hour, 1 hour, amount of water is respectively 10 times, 10 times, 8 times, merging filtrate concentrating under reduced pressure (70 DEG C) is to about 8.0L, add 95% ethanol to be about 7500ml and to reach 50% to alcohol content, stir, room temperature places about 10h, filter, concentrating under reduced pressure reclaims ethanol extremely without alcohol taste, and be concentrated into the clear paste that relative density is 1.32 (75 DEG C), granule made by the adjuvant (cane sugar powder: dextrin=60:1) adding 4 times of fashionable clear paste weight, dry, make granule and be about 1195g, pack, every bag of 10g.
Test example 1
In comparing embodiment 1 ~ 7, granule granulation difficulty or ease and hygroscopicity, the results are shown in Table 1
Hygroscopicity Acceleration study: get that each group granule 50 bags (every bag of 10g) is aluminum-plastic packaged is placed in RH75%, temperature is under the condition of (40 ± 1) DEG C, respectively at 0,1,2, March four sub-sampling observe.
Embodiment 1-4 is that embodiment 5-6 is with the granule prepared by clarifier process with clarifier and the granule prepared by clarifier pretreating agent, and embodiment 7 is the granules using the method for traditional water extract-alcohol precipitation to prepare.
Above-mentioned result of the test explanation clarifier and the granule prepared by clarifier pre-treatment treatment improve that alcohol precipitation process difficulty is granulated, the shortcoming of the easy moisture absorption caking of the granule made.
Test example 2
Paeoniflorin content in comparing embodiment 1 ~ 7 in paste-forming rate and the granule prepared, the results are shown in Table 2:
Clear paste paste-forming rate (%)=(clear paste weight ÷ medical material gross weight) × 100%
In each embodiment of table 2, in paste-forming rate and every bag of granule preparing, paeoniflorin content compares (by every bag of 10g)
Embodiment 1-4 is that embodiment 5-6 is with the granule prepared by clarifier process with clarifier and the granule prepared by clarifier pretreating agent, and embodiment 7 is the granules using the method for traditional water extract-alcohol precipitation to prepare.Above-mentioned result of the test illustrates that the paste-forming rate after using clarifier and clarifier pre-treatment treatment is apparently higher than alcohol precipitation process, but prepared granule reach in pharmacopeia 2010 editions to the paeoniflorin content in KANGKAN KELI require (every bag containing Radix Paeoniae Rubra in peoniflorin, must not 55.0mg be less than) while also high than the content of the peoniflorin in the granule prepared by alcohol precipitation process, and under the adjuvant that consumption is less, prepared more granule improve output; Clarifier pre-treatment treatment makes granule immersion character be improved in addition.
Test example 3
The content of the Dryocrassine in the granule prepared in comparing embodiment 1 ~ 7, as table 3:
Because embodiment 1-4 is that embodiment 5-6 is with the granule prepared by clarifier process with the granule prepared by clarifier and clarifier pretreating agent, embodiment 7 is the granules using the method for traditional water extract-alcohol precipitation to prepare.By measuring the content of Dryocrassine in the finished particle prepared by embodiment 1-7 respectively, as can be seen from the Comparative result in table 3, the granule that in the granule using clarifier process medicinal liquid to prepare, the content of Dryocrassine is prepared apparently higher than alcohol deposition method; It can also be seen that the content of the Dryocrassine in the granule prepared by the embodiment 1-4 of clarifier and clarifier pretreating agent conbined usage is apparently higher than embodiment 5-6 simultaneously.
In sum, the paste-forming rate of the clear paste obtained after carrying out remove impurity process by the extracting solution of technical solutions according to the invention to the Flos Lonicerae of recipe quantity, Radix Paeoniae Rubra, Rhizoma Dryopteris Crassirhizomatis is higher than alcohol precipitation process, and the content of peoniflorin in the granule prepared meets the content requirement at pharmacopeia peoniflorin; Use technical scheme of the present invention to also solve the shortcoming of granulation difficulty in alcohol precipitation process, granule easy moisture absorption caking simultaneously; Compared with traditional handicraft, the loss of Dryocrassine in dedoping step greatly reduces and adds productivity effect; Overall economic efficiency considers that technical solutions according to the invention improve output under the prerequisite ensureing granular mass.
Claims (7)
1. be used for the treatment of a preparation method for the Chinese medicine preparation of flu, it is characterized in that, comprise the steps: extracting honeysuckle 700 parts, Radix Paeoniae Rubra 700 parts, Rhizoma Dryopteris Crassirhizomatis 233 parts, after medical material pre-treatment, soak, add 4-10 times of soak by water, merge extractive liquid, filter, add natural clarifying agent pretreating agent after concentrated and stir, boil, then add natural clarifying agent to boil, let cool, room temperature leave standstill, getting supernatant concentration to relative density is 1.3-1.35(75 DEG C) clear paste; Described clear paste mixes with the ratio of adjuvant in 1:4 ~ 1:6, adds adjuvant and makes granule, dry, to obtain final product.
2. preparation method according to claim 1, is characterized in that, comprises the steps:
(1) get the Flos Lonicerae of recipe quantity, Radix Paeoniae Rubra, Rhizoma Dryopteris Crassirhizomatis, respectively after pre-treatment, add Aqua pure extract 2-3 time, each amount of water is 4-10 times of crude drug, and merge extractive liquid, filters, after filtrate reduced in volume, add ZTC1+1 natural clarifying agent pretreating agent A and stir, boil; Fluid temperature is cooled to the 50-80 DEG C of ZTC1+1 natural clarifying agent pretreating agent B adding equivalent to stir, insulation, boils, after add ZTC1+1 natural clarifying agent B and stir, insulation; Add ZTC1+1 natural clarifying agent A to stir, boil, let cool, room temperature places about 8-15 hour, high speed centrifugation, and it is 1.3-1.35(75 DEG C that supernatant is evaporated to relative density) clear paste;
(2) clear paste described in step (1) is mixed with the ratio of adjuvant in 1:4 ~ 1:6, add adjuvant and make granule, dry, to obtain final product.
3. preparation method according to claim 1, it is characterized in that, comprise the steps: that (1) gets the Flos Lonicerae of recipe quantity, Radix Paeoniae Rubra, Rhizoma Dryopteris Crassirhizomatis, add Aqua pure extract 2-3 time, each 1-2 hour, amount of water is 4-10 times of crude drug, collecting decoction, filter, filtrate reduced in volume is to certain volume, the ZTC1+1 natural clarifying agent pretreating agent A adding the 0.1%-1% of crude drug stirs, and boils; Fluid temperature is cooled to the 50-80 DEG C of ZTC1+1 natural clarifying agent pretreating agent B adding equivalent to stir, insulation 5-7 hour, boil 10-30 minute, the 2-10%ZTC1+1 natural clarifying agent B adding medicine liquid volume after fluid temperature drops to 60-80 DEG C stirs, and is incubated 20 minutes; The ZTC1+1 natural clarifying agent A adding the 2%-8% of medicine liquid volume stirs, and boils 30-60 minute; Let cool, room temperature places about 8-15 hour, high speed centrifugation, and it is 1.3-1.35(75 DEG C that supernatant is evaporated to relative density) clear paste;
(2) clear paste described in step (1) is mixed with the ratio of adjuvant in 1:4 ~ 6, add adjuvant and make granule, dry, to obtain final product.
4. preparation method according to claim 1, is characterized in that, the ZTC1+1 natural clarifying agent described in step (1) is the one in ZTC1+1 II type or ZTC1+1 III type.
5. preparation method according to claim 1, is characterized in that, the adjuvant described in step (2) is cane sugar powder and dextrin, wherein cane sugar powder: dextrin=50 ~ 60:1.
6. the preparation method of the Chinese medicine preparation according to claim 1-5, is characterized in that, the Radix Paeoniae Rubra in described Chinese medicine preparation finished product is in peoniflorin, and content is no less than 5.5mg/g.
7. the preparation method of the Chinese medicine preparation according to claim 1-5, is characterized in that, described Chinese medicine preparation has effect of heat-clearing and toxic substances removing, and for the heating that affection due to external wind and heat causes, headache, nasal obstruction, sneeze, pharyngalgia has obvious curative effect.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114504608A (en) * | 2020-11-17 | 2022-05-17 | 四川好医生攀西药业有限责任公司 | Anti-cold granules and preparation method thereof |
| CN117530951A (en) * | 2024-01-09 | 2024-02-09 | 中国中医科学院中药研究所 | Composition for treating cold and preparation method and application thereof |
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2014
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114504608A (en) * | 2020-11-17 | 2022-05-17 | 四川好医生攀西药业有限责任公司 | Anti-cold granules and preparation method thereof |
| CN114504608B (en) * | 2020-11-17 | 2023-01-17 | 四川好医生攀西药业有限责任公司 | Anti-cold granules and preparation method thereof |
| CN117530951A (en) * | 2024-01-09 | 2024-02-09 | 中国中医科学院中药研究所 | Composition for treating cold and preparation method and application thereof |
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