CN105079135A - Traditional Chinese medicine combination used for treating cold and preparation method thereof - Google Patents
Traditional Chinese medicine combination used for treating cold and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine combination used for treating cold and a preparation method thereof. The traditional Chinese medicine combination is composed of honeysuckle, red peony root and male fern rhizome. Active ingredients in three Chinese medicinal herbs are extracted through ultrahigh-pressure extraction technology, a clarifying agent and a clarifying agent pretreating agent are used to perform impurity removal on extract, and pharmaceutically acceptable excipients are added after the extract is concentrated to be clear paste to prepare the traditional Chinese medicine like granules and capsules having efficacy of clearing heat and detoxifying.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicine preparation, particularly a kind of Chinese medicine composition for the treatment of flu and preparation method thereof.
Background technology
Flu, be a kind of self-healing property disease, clinical manifestation is its feature with nasal obstruction, cough, headache, fever with aversion to cold, general malaise, and the whole year all can fall ill.Common cold is divided into again common cold and influenza clinically.Common cold, the traditional Chinese medical science claims " cold ", is a kind of respiratory tract commonly encountered diseases caused by multiple virus.Influenza is the Acute respiratory infectious disease caused by influenza virus.At present, the medicine great majority being used for the treatment of flu are on the market all Western medicine, and Western medicine can only be applied to cold symptoms occur after alleviation, for multiple viral influenza, effect is undesirable, and toxic and side effects is large, effectively can not improve the immunologic function of human body self.So use western medicine flu to there is the defect of integrated control effect difference.
In the product that existing Chinese patent drugs for treatment is caught a cold, wherein comparitive study significantly has KANGKAN KELI, its constituent is Flos Lonicerae, Radix Paeoniae Rubra, Rhizoma Dryopteris Crassirhizomatis, preparation technology is conventional decoction and alcohol sedimentation technique, technological deficiency is wherein that decoction and alcohol sedimentation technique is incomplete to the extracts active ingredients in Chinese crude drug, and owing to containing a large amount of starch in component Radix Paeoniae Rubra, easily be burned in soak by water process, the viscosity of decoction liquor is large, follow-up filtration step is made to become difficulty, extractum viscosity also corresponding increase after concentrated, increase the difficulty of granulation, add investment of production cost simultaneously.Stronger in medicament storage hygroscopicity, cause product to lump, be difficult to reach and still remain valid in effect duration.
Summary of the invention
The present invention is in order to solve above-mentioned technological deficiency, it is particularly in KANGKAN KELI preparation technology because the content of starch in Radix Paeoniae Rubra is high, soak by water process is easily burned, the decoction liquor filtration difficulty simultaneously obtained, extractum viscosity is large, granulate difficulty, the defect of the easy moisture absorption of granule, the object of the present invention is to provide the preparation method that a kind of Chinese medicine preparation being used for the treatment of flu is new.
The present invention also aims to the application that a kind of above-mentioned Chinese medicine preparation is provided.
A kind of Chinese medicine preparation being used for the treatment of flu described in the present invention, comprises the component of following weight portion: Flos Lonicerae 700 parts, Radix Paeoniae Rubra 700 parts, Rhizoma Dryopteris Crassirhizomatis 233 parts.
A kind of preparation method being used for the treatment of the Chinese medicine preparation of flu of the present invention is achieved through the following technical solutions:
Extracting honeysuckle 700 parts, Radix Paeoniae Rubra 700 parts, Rhizoma Dryopteris Crassirhizomatis 233 parts, after medical material pre-treatment, soak, hyperpressure extraction, merge extractive liquid, filter, add natural clarifying agent pretreating agent after concentrated and stir, boil, then add natural clarifying agent to boil, let cool, room temperature leaves standstill, and gets the clear paste that supernatant concentration to relative density is 1.3-1.35 (75 DEG C); Described clear paste mixes with the ratio of adjuvant in 1:4 ~ 1:6, adds adjuvant and makes granule, dry, to obtain final product.
Further optimisation technique scheme is that (1) gets the Flos Lonicerae of recipe quantity, Radix Paeoniae Rubra, Rhizoma Dryopteris Crassirhizomatis, respectively after process, soak 10-30 minute, hyperpressure extraction 1-3 time, each 10-30 minute, merge extractive liquid, filter, after filtrate reduced in volume, the ZTC1+1 natural clarifying agent pretreating agent A adding the 0.2%-1% of crude drug stirs, and boils; Fluid temperature is cooled to the 50-80 DEG C of ZTC1+1 natural clarifying agent pretreating agent B adding equivalent to stir, insulation, boils, after add ZTC1+1 natural clarifying agent B and stir, insulation; Add ZTC1+1 natural clarifying agent A to stir, boil, let cool, room temperature places about 8-15 hour, high speed centrifugation, and supernatant is evaporated to the clear paste that relative density is 1.3-1.35 (75 DEG C);
(2) clear paste described in step (1) is mixed with the ratio of adjuvant in 1:4 ~ 1:6, add adjuvant and make granule, dry, to obtain final product.
Further be, hyperpressure extraction 1-3 time in step (1), each 10-30 minute, merge extractive liquid, filter, after filtrate reduced in volume, the ZTC1+1 natural clarifying agent pretreating agent A adding the 0.2%-1% of crude drug stirs, and boils; Fluid temperature is cooled to the 50-80 DEG C of ZTC1+1 natural clarifying agent pretreating agent B adding equivalent to stir, insulation 5-7 hour, boil 10-30 minute, the 2-10%ZTC1+1 natural clarifying agent B adding medicine liquid volume after fluid temperature drops to 60-80 DEG C stirs, and is incubated 20 minutes; The ZTC1+1 natural clarifying agent A adding the 2%-8% of medicine liquid volume stirs, and boil 30-60 minute, let cool, room temperature places about 8-15 hour, high speed centrifugation, and supernatant is evaporated to the clear paste that relative density is 1.3-1.35 (75 DEG C).
Supertension described in step (1), condition is 200-600MPa.
ZTC1+1 natural clarifying agent described in step (1) is ZTC1+1 II type, the one in ZTC1+1 III type.
Adjuvant described in step (2) is cane sugar powder and dextrin, wherein cane sugar powder: dextrin=50 ~ 60:1.
Granule described in the present invention has effect of heat-clearing and toxic substances removing, and for the heating that affection due to external wind and heat causes, headache, nasal obstruction, sneeze, pharyngalgia has obvious curative effect.
Compared with prior art, the beneficial effect had is in the present invention:
1. use supertension Flos Lonicerae, Radix Paeoniae Rubra, Rhizoma Dryopteris Crassirhizomatis are extracted, to a greater extent by extracts active ingredients out, in the granule prepared, the content of peoniflorin is higher than traditional decoction and alcohol sedimentation technique;
2. use easy granulation compared with traditional alcohol precipitation process after clarifier and clarifier pre-treatment treatment, and the granule made not easily moisture absorption caking, granule soak is limpid;
3. the paste-forming rate of the technical scheme gained clear paste described in the present invention is higher than the paste-forming rate of aqueous extraction-alcohol precipitation technology, the consumption of adjuvant can be reduced, the granule prepared meets pharmacopeia 2010 editions regulations to paeoniflorin content in KANGKAN KELI, overall economic efficiency considers that technical solutions according to the invention also improve output while raising granular mass, has saved production cost.
Detailed description of the invention
1. material and instrument:
Medical material: Flos Lonicerae Radix Paeoniae Rubra Rhizoma Dryopteris Crassirhizomatis is purchased from Chinese crude drug wholesale market, International trade city, Chengdu.
Reagent: be analytical pure methanol (Chengdu Ke Long chemical reagent factory); Peoniflorin reference substance (middle inspection institute lot number: 110736200527).Dryocrassine reference substance (Institute of Analysis of Sichuan University provides, purity 98%) ZTC1+1 natural clarifying agent pretreating agent A and B is purchased from Tianjin Zheng Tiancheng clarification technique company limited.
ZTC1+1 natural clarifying agent (Tianjin Zheng Tiancheng clarification technique company limited).
Instrument: Agilent 1200 high performance liquid chromatograph.
2. the preparation of clarifier:
2.1ZTC1+1 natural clarifying agent (Tianjin Zheng Tiancheng clarification technique company limited) is the polymer substance extracted from food.
2.2 preparations:
Component A: first become pasty state by a small amount of deionized water and stirring, then add requirement deionized water, swelling 24 hours, stirs, filters, obtain 1% viscose solution with double gauze.
B component: first with the acetum of glacial acetic acid and deionized water preparation 1%, then stir into pasty state by 1% a small amount of acetate dissolution B component, add 1% acetic acid of q.s, swelling 24 hours, stir, filter with double gauze, obtain 1% viscose solution.
3 paeoniflorin contents measure
3.1 reference substance solution preparations: precision takes peoniflorin reference substance 1.57mg 20% methanol constant volume to 10ml product solution in contrast
3.2 sample preparations:
Get the filtrate 2ml pure water after clarification and be settled to 25ml as test sample 1;
Get the finished granule made to pulverize, precision takes 0.6g, puts in tool plug conical flask, precision adds methanol 50ml, weighed weight, supersound process 10 minutes, let cool, weigh, supply minimizing weight with methanol, shake up, leave standstill, precision measures supernatant 10ml, evaporate to dryness, residue 20% dissolve with methanol, adds 20% methanol to 10ml, shake up, centrifugally namely obtain test sample 2.
3.3 paeoniflorin contents measure: measure with reference to 2010 editions pharmacopeia KANGKAN KELI peoniflorin assay method.
4. Dryocrassine assay:
The drafting of 4.1 standard curves: it is appropriate that precision takes Dryocrassine reference substance, and making concentration with chloroform is 0.198mg.ml
-1reference substance solution, sample introduction 2 μ l, 4 μ l, 6 μ l, 8 μ l, 10 μ l respectively, with acetonitrile-chloroform-isopropanol-0.3% phosphoric acid-0.1% sodium lauryl sulphate (50:10:35:10:5) for mobile phase, 286nm is determined wavelength, utilizes high performance liquid chromatograph to measure.Carry out linear regression with the peak area y of gained Dryocrassine to sample size x (μ g), regression equation is: y=1E+06x-41054, R=0.9996; Result shows, Dryocrassine sample size is good in 0.396-1.98ug internal linear relation in scope.
Dryocrassine assay in 3.2 samples: get the finished granule made and grind, take 0.6g, put in tool plug conical flask, precision adds people's chloroform 40mL, and close plug, weighs, and supersound extraction 30min lets cool, then weighs, and supplies the quality of less loss, shake up with chloroform.Filter, get subsequent filtrate 5mL in 10mL measuring bottle, add chloroform and be settled to scale, shake up, microporous filter, get supernatant, sample size is 10 μ l.Measure chromatographic condition consistent with the chromatographic condition of preparation standard curve, obtain the content of Dryocrassine in finished particle.
Embodiment 1:
Take Flos Lonicerae 2100g, Radix Paeoniae Rubra 2100g, Rhizoma Dryopteris Crassirhizomatis 699g, after three taste medical materials are done pulverization process respectively, add pure water and soak 20 minutes, medical material puts into hyperpressure extraction device together with soak, extracts 3 times under the pressure of 400MPa, each 10 minutes, merge three extracting solution, filter, filtrate reduced in volume (70 DEG C) is to about 8L, the 0.2%ZTC1+1 natural clarifying agent pretreating agent A adding crude drug total amount stirs, and boils 20 minutes; Fluid temperature is cooled to about 60 DEG C of ZTC1+1 natural clarifying agent pretreating agent B adding equivalent to stir, 60 DEG C of insulations about 6 hours, boil 30 minutes, treat that fluid temperature is down to 70 DEG C and is added 6%ZTC1+1 natural clarifying agent II B and stir, be incubated 20 minutes; Add 2%ZTC1+1 natural clarifying agent II A to stir, boil 1 hour.Let cool, room temperature places about 10h, filters, be evaporated to the clear paste that relative density is 1.32 (75 DEG C), granule made by the adjuvant (cane sugar powder: dextrin=50:1) adding 4 times of clear paste, dry, make granule and be about 3759g, pack, every bag of 10g.
Embodiment 2:
Take Flos Lonicerae 2100g, Radix Paeoniae Rubra 2100g, Rhizoma Dryopteris Crassirhizomatis 699g, after three taste medical materials are carried out pulverization process respectively, add pure water and soak 10 minutes, medical material is put into hyperpressure extraction device together with soak, extracts 2 times under the condition of 600MPa, 15 minutes first times, second time 10 minutes, 1.5 hours, 1 hour, merge extracted twice liquid, filter, filtrate reduced in volume (70 DEG C) is to about 8.3L, and the 0.2%ZTC1+1 natural clarifying agent pretreating agent A adding crude drug total amount stirs, and boils 20 minutes; Fluid temperature is cooled to about 60 DEG C of ZTC1+1 natural clarifying agent pretreating agent B adding equivalent to stir, 60 DEG C of insulations about 6 hours, boil 30 minutes, treat that fluid temperature is down to 70 DEG C and is added 6%ZTC1+1 natural clarifying agent III B and stir, be incubated 20 minutes; Add 2%ZTC1+1 natural clarifying agent III A to stir, boil 1 hour.Let cool, room temperature places about 10h, filters, be evaporated to the clear paste that relative density is 1.32 (75 DEG C), granule made by the adjuvant (cane sugar powder: dextrin=50:1) adding 5 times of clear paste, dry, make granule and be about 3670g, pack, every bag of 10g.
Embodiment 3:
Take Flos Lonicerae 1400g, Radix Paeoniae Rubra 1400g, Rhizoma Dryopteris Crassirhizomatis 466g, after three taste medical materials respectively pulverization process, add pure water and soak 30 minutes, put in hyperpressure extraction device by medical material together with soak, extract 1 time under the condition of 200MPa, extraction time is 30 minutes, filter, filtrate reduced in volume (70 DEG C) is to about 10L, and the 1%ZTC1+1 natural clarifying agent pretreating agent A adding crude drug total amount stirs, and boils 10 minutes; Fluid temperature is cooled to about 50 DEG C of ZTC1+1 natural clarifying agent pretreating agent B adding equivalent to stir, 50 DEG C of insulations about 7 hours, boil 10 minutes, treat that fluid temperature is down to 60 DEG C and is added 3%ZTC1+1 natural clarifying agent II B and stir, be incubated 20 minutes; Add 1%ZTC1+1 natural clarifying agent II A to stir, boil 30 minutes.Let cool, room temperature places about 15h, filters, be evaporated to the clear paste that relative density is 1.35 (75 DEG C), granule made by the 5 times amount adjuvants (cane sugar powder: dextrin=60:1) adding clear paste, dry, make granule and be about 2773g, pack, every bag of 10g.
Embodiment 4:
Take Flos Lonicerae 700g, Radix Paeoniae Rubra 700g, Rhizoma Dryopteris Crassirhizomatis 233g, after three taste medical materials respectively pulverization process, add pure water and soak 20 minutes, medical material is put in hyperpressure extraction device together with soak, extract 3 times under the condition of 200MPa, each time is 10 minutes, merge three extracting solution, filter, filtrate reduced in volume (70 DEG C) is to about 13L, the 0.5%ZTC1+1 natural clarifying agent pretreating agent A adding crude drug total amount stirs, and boils 20 minutes; Fluid temperature is cooled to about 80 DEG C of ZTC1+1 natural clarifying agent pretreating agent B adding equivalent to stir, is incubated about 5 hours, boils 30 minutes, treat that fluid temperature is down to 80 DEG C and is added 10%ZTC1+1 natural clarifying agent III B and stir, be incubated 30 minutes; Add 3%ZTC1+1 natural clarifying agent III A to stir, boil 40 minutes.Let cool, room temperature places about 8h, filters, be evaporated to the clear paste that relative density is 1.31 (75 DEG C), granule made by the 6 times amount adjuvants (cane sugar powder: dextrin=60:1) adding clear paste, dry, make granule and be about 1301g, pack, every bag of 10g.
Embodiment 5:
Take Flos Lonicerae 7000g, Radix Paeoniae Rubra 7000g, Rhizoma Dryopteris Crassirhizomatis 2330g, after three taste medical materials respectively pulverization process, add pure water and soak 30 minutes, medical material is put in hyperpressure extraction device together with soak, extract 2 times under the condition of 400MPa, each 10 minutes, merge extracted twice liquid, filter, filtrate reduced in volume (70 DEG C) is to about 163L, after heating concentrated solution to 70 DEG C, 6%ZTC1+1 natural clarifying agent II B adding medicine liquid volume stirs, and is incubated 20 minutes; Add 2%ZTC1+1 natural clarifying agent II A to stir, boil 1 hour.Let cool, room temperature places about 10h, filters, be evaporated to the clear paste that relative density is 1.3 (75 DEG C), granule made by the adjuvant (cane sugar powder: dextrin=50:1) adding 4 times of clear paste, dry, make granule and be about 17856g, pack, every bag of 10g.
Embodiment 6:
Take Flos Lonicerae 700g, Radix Paeoniae Rubra 700g, Rhizoma Dryopteris Crassirhizomatis 233g, after three taste medical materials respectively pulverization process, add pure water and soak 20 minutes, medical material is put in hyperpressure extraction device together with soak, extract 2 times under the condition of 400MPa, each 10 minutes, merge extracted twice liquid, filter, filtrate reduced in volume (70 DEG C) is to about 8.0L, add 95% ethanol to be about 7500ml and to reach 50% to alcohol content, stir, room temperature places about 10h, filter, concentrating under reduced pressure reclaims ethanol extremely without alcohol taste, and be concentrated into the clear paste that relative density is 1.3 (75 DEG C), granule made by the adjuvant (cane sugar powder: dextrin=60:1) adding 6 times of fashionable clear paste weight, dry, make granule and be about 1505g, pack, every bag of 10g.
Embodiment 7:
Take Flos Lonicerae 700g, Radix Paeoniae Rubra 700g, Rhizoma Dryopteris Crassirhizomatis 233g, add Aqua pure extract 3 times, extraction time is respectively 2 hours, 1.5 hour, 1 hour, amount of water is respectively 10 times, 10 times, 8 times, merging filtrate concentrating under reduced pressure (70 DEG C) is to about 8.0L, add 95% ethanol to be about 7500ml and to reach 50% to alcohol content, stir, room temperature places about 10h, filter, concentrating under reduced pressure reclaims ethanol extremely without alcohol taste, and be concentrated into the clear paste that relative density is 1.3, granule made by the adjuvant (cane sugar powder: dextrin=60:1) adding 5 times of fashionable clear paste weight, dry, make granule and be about 1095g, pack, every bag of 10g.
Now the technical scheme that embodiment 1-7 uses is further described: embodiment 1-4 replaces soak by water to extract the effective ingredient in medical material with supertension, extracting solution clarifier and the granule prepared by clarifier pretreating agent; Embodiment 5 adopts hyperpressure extraction technology to combine with clarifier adsorption clarification to prepare granule; Embodiment 6 adopts hyperpressure extraction technology to combine with traditional precipitate with ethanol technology to prepare granule; Embodiment 7 adopts traditional water extract-alcohol precipitation technology to prepare granule.
In comparing embodiment 1 ~ 7, granule granulation difficulty or ease and hygroscopicity, the results are shown in Table 1
Hygroscopicity Acceleration study: get that each group granule 50 bags (every bag of 10g) is aluminum-plastic packaged is placed in RH75%, temperature is under the condition of (40 ± 1) DEG C, respectively at 0,1,2, March four sub-sampling observe.
Above-mentioned result of the test explanation clarifier and the granule prepared by clarifier pre-treatment treatment improve that alcohol precipitation process difficulty is granulated, the shortcoming of the easy moisture absorption caking of the granule made.
Paeoniflorin content in comparing embodiment 1 ~ 7 in paste-forming rate and the granule prepared, the results are shown in Table 2:
Clear paste paste-forming rate (%)=(clear paste weight ÷ medical material gross weight) × 100%
In each embodiment of table 2, in paste-forming rate and every bag of granule preparing, paeoniflorin content compares (by every bag of 10g)
Above-mentioned result of the test illustrates the content adopting superhigh pressure technique greatly can improve the peoniflorin in prepared granule, and clarifier pretreating agent and clarifier combine, make the granule soak limpid portion muddiness prepared, improve the quality of granule, and prepared granule meets pharmacopeia 2010 editions to paeoniflorin content in KANGKAN KELI (Radix Paeoniae Rubra is in peoniflorin in every bag of granule, must not be less than 55.0mg).
The content of the Dryocrassine in the granule prepared in comparing embodiment 1 ~ 7, the results are shown in Table 3:
| Group | Inventory | Make total number of particles (g) | Dryocrassine relative amount (mg/g) |
| Embodiment 1 | 3 recipe quantities | 3759 | 4.532 |
| Embodiment 2 | 3 recipe quantities | 3670 | 4.601 |
| Embodiment 3 | 2 recipe quantities | 2773 | 4.045 |
| Embodiment 4 | 1 recipe quantity | 1301 | 3.933 |
| Embodiment 5 | 10 recipe quantities | 17856 | 3.387 |
| Embodiment 6 | 1 recipe quantity | 1505 | 2.701 |
| Embodiment 7 | 1 recipe quantity | 1095 | 1.891 |
As can be seen from data in table 3, adopt the content of Dryocrassine in the granule prepared by embodiment 1-6 of hyperpressure extraction apparently higher than traditional water extraction; Simultaneously by clarifier and clarifier pretreating agent conjunctive use to the embodiment 1-4 in dedoping step, in the granule finally prepared, the content of Dryocrassine is than only high with the content of the embodiment 5 of clarifier remove impurity; The hyperpressure extraction that embodiment 6 uses, precipitate with ethanol remove impurity, be not difficult to find out that from result data the loss of Dryocrassine is larger.
In sum, although the paste-forming rate of the clear paste obtained after carrying out remove impurity process by the extracting solution of technical solutions according to the invention to the Flos Lonicerae of recipe quantity, Radix Paeoniae Rubra, Rhizoma Dryopteris Crassirhizomatis is higher than alcohol precipitation process, the content of the peoniflorin in the granule prepared is higher than the granule prepared by traditional aqueous extraction-alcohol precipitation technology; Use technical scheme of the present invention to also solve the shortcoming of granulation difficulty in alcohol precipitation process, granule easy moisture absorption caking simultaneously; Use hyperpressure extraction to considerably increase the dissolution rate of effective ingredient, clarifier and clarifier pretreating agent conbined usage are reduced the loss of Dryocrassine; Overall economic efficiency considers that technical solutions according to the invention also improve output under the prerequisite improving granular mass.
Claims (8)
1. be used for the treatment of a preparation method for the Chinese medicine composition of flu, it is characterized in that, comprise the steps: extracting honeysuckle 700 parts, Radix Paeoniae Rubra 700 parts, Rhizoma Dryopteris Crassirhizomatis 233 parts, after medical material pre-treatment, soak, hyperpressure extraction, merge extractive liquid, filter, add natural clarifying agent pretreating agent after concentrated and stir, boil, then add natural clarifying agent to boil, let cool, room temperature leave standstill, getting supernatant concentration to relative density is 1.3-1.35(75 DEG C) clear paste; Described clear paste mixes with the ratio of adjuvant in 1:4 ~ 1:6, adds adjuvant and makes granule, dry, to obtain final product.
2. preparation method according to claim 1, is characterized in that, comprises the steps:
(1) Flos Lonicerae of recipe quantity, Radix Paeoniae Rubra, Rhizoma Dryopteris Crassirhizomatis is got, respectively after process, soak 10-30 minute, hyperpressure extraction 1-3 time, each 10-30 minute, merge extractive liquid, filter, after filtrate reduced in volume, the ZTC1+1 natural clarifying agent pretreating agent A adding the 0.2%-1% of crude drug stirs, and boils; Fluid temperature is cooled to the 50-80 DEG C of ZTC1+1 natural clarifying agent pretreating agent B adding equivalent to stir, insulation, boils, after add ZTC1+1 natural clarifying agent B and stir, insulation; Add ZTC1+1 natural clarifying agent A to stir, boil, let cool, room temperature places about 8-15 hour, high speed centrifugation, and it is 1.3-1.35(75 DEG C that supernatant is evaporated to relative density) clear paste;
(2) clear paste described in step (1) is mixed with the ratio of adjuvant in 1:4 ~ 1:6, add adjuvant and make granule, dry, to obtain final product.
3., according to the preparation method described in claim 1, it is characterized in that step (1) middle hyperpressure extraction 1-3 time, each 10-30 minute, merge extractive liquid, filters, after filtrate reduced in volume, the ZTC1+1 natural clarifying agent pretreating agent A adding the 0.2%-1% of crude drug stirs, and boils; Fluid temperature is cooled to the 50-80 DEG C of ZTC1+1 natural clarifying agent pretreating agent B adding equivalent to stir, insulation 5-7 hour, boil 10-30 minute, the 2-10%ZTC1+1 natural clarifying agent B adding medicine liquid volume after fluid temperature drops to 60-80 DEG C stirs, and is incubated 20 minutes; The ZTC1+1 natural clarifying agent A adding the 2%-8% of medicine liquid volume stirs, and boil 30-60 minute, let cool, room temperature places about 8-15 hour, high speed centrifugation, and it is 1.3-1.35(75 DEG C that supernatant is evaporated to relative density) clear paste.
4. preparation method according to claim 1, is characterized in that, the supertension described in step (1), and condition is 200-600MPa.
5. preparation method according to claim 1, is characterized in that, the ZTC1+1 natural clarifying agent described in step (1) is ZTC1+1 II type, the one in ZTC1+1 III type.
6. preparation method according to claim 1, is characterized in that, the adjuvant described in step (2) is cane sugar powder and dextrin, wherein cane sugar powder: dextrin=50 ~ 60:1.
7. the preparation method of the Chinese medicine composition according to claim 1-6, is characterized in that, described Chinese medicine composition is containing Radix Paeoniae Rubra in peoniflorin, and content is at least 5.5mg/g.
8. the preparation method of the Chinese medicine composition according to claim 1-6, is characterized in that, described Chinese medicine composition has effect of heat-clearing and toxic substances removing, and for the heating that affection due to external wind and heat causes, headache, nasal obstruction, sneeze, pharyngalgia has obvious curative effect.
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| CN114504608A (en) * | 2020-11-17 | 2022-05-17 | 四川好医生攀西药业有限责任公司 | Anti-cold granules and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101933967A (en) * | 2010-08-31 | 2011-01-05 | 蚌埠丰原涂山制药有限公司 | Honeysuckle extract preparation method |
-
2014
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101933967A (en) * | 2010-08-31 | 2011-01-05 | 蚌埠丰原涂山制药有限公司 | Honeysuckle extract preparation method |
Non-Patent Citations (2)
| Title |
|---|
| 罗明生等，: "《药剂辅料大全》", 31 January 2006, 四川科学技术出版社 * |
| 黄启德等: "《四川省川东北片区药学学术研讨会文集》", 30 April 2003 * |
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| CN114504608A (en) * | 2020-11-17 | 2022-05-17 | 四川好医生攀西药业有限责任公司 | Anti-cold granules and preparation method thereof |
| CN114504608B (en) * | 2020-11-17 | 2023-01-17 | 四川好医生攀西药业有限责任公司 | Anti-cold granules and preparation method thereof |
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