CN1063077C - Traditional Chinese medicine composition for lowering blood-lipid, and method for preparing same - Google Patents
Traditional Chinese medicine composition for lowering blood-lipid, and method for preparing same Download PDFInfo
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- CN1063077C CN1063077C CN 98100188 CN98100188A CN1063077C CN 1063077 C CN1063077 C CN 1063077C CN 98100188 CN98100188 CN 98100188 CN 98100188 A CN98100188 A CN 98100188A CN 1063077 C CN1063077 C CN 1063077C
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- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to a traditional Chinese medicine composition for lowering blood fat and a preparation method thereof. The traditional Chinese medicine composition is prepared from 11 traditional Chinese medicines; the preparation method comprises the following steps: crushing several kinds of the traditional Chinese medicines; extracting the crushed traditional Chinese medicine with water twice; concentrating the extracts into liquid extract; mixing the liquid extract with the rest crushed traditional Chinese medicines; drying and crushing the mixture; preparing the crushed mixture into granules by using the aqueous solution of ethanol as an adhesive agent; drying the granules. The traditional Chinese medicine composition has the advantages of good curative effect, short treatment course, cheap price, no toxic or side effect and simple preparation technology.
Description
The present invention relates to derive from the Chinese drugs agentia of vegetable material, Chinese drugs agentia of a kind of blood fat reducing of more specifically saying so and preparation method thereof.
Middle-aged and elderly people blood fat height in the last few years, the patient of brain cardiovascular disease increases, and blood flow is just learned and is checked and show that the blood viscosity index exceeds standard.Because the blood fat height causes the disease of serious harm people life such as myocardial infarction, cerebral thrombosis easily.Therefore the problem that how to make hyperlipemic patients reduce to normal value has caused the common concern of the researcher of medical profession.
Using more fat-reducing medicament clinically in China has unsaturated fatty acids, and this class medicine comprises bathypelagic fish oil preparation such as Max EPA, the happy health of arteries and veins and Squalene etc.They all are 22 carbon and 26 carbon polyenoid class unsaturated fatty acids.Though they have certain curative effect, curative effect is not fairly obvious, and the course of treatment is long, and the happy health of for example arteries and veins that has costs an arm and a leg.Another kind of medicine trade name is the lipid lowerers of " Xuezhikang ", is to utilize Semen oryzae sativae to add culture fluid for raw material, and the inoculation Monascus Strains forms at the condition bottom fermentation of the temperature and time that suits.This be utilize that biotechnology makes contain cholesterol synthase inhibitor and unsaturated fatty acid.But the effective percentage of its cholesterol reducing has only 23%, and the effective percentage that falls serum triglycerides is 36.5%.4 months its courses of treatment of another kind of medicine clofibrate derivant " gemfibrozil capsule ", easily bounce-back after the drug withdrawal.The special good effects such as fat, fat Kangping of transferring of the fat-reducing medicament of import, short treating period, but also cost an arm and a leg, toxic reaction is especially very important to the toxic reaction of liver, and also very easily bounce-back in the short time after the drug withdrawal.
Chinese patent literature CN1062082 has reported a kind of fat-reducing and has adjusted blood fat masking liquid and compound method thereof, it is respectively with different solvents by Rhizoma Alismatis, Pericarpium Citri Reticulatae, Poria, the Rhizoma Atractylodis Macrocephalae, the Radix Angelicae Dahuricae, the Radix Paeoniae Alba, Flos Chrysanthemi, Semen Armeniacae Amarum etc., effective component extracting therefrom, after concentrating, become the extractum shape, adopt different emulsifying agents and emulsification method then, add skin penetrant, spice is composite forms.Its effective percentage reaches 91.2%, and technology is comparatively complicated.
Another piece Chinese patent literature CN1067179 has reported a kind of hypolipidemic, and it is by 8 flavor Chinese medicine components such as Radix Polygoni Multiflori, through being processed into dosage forms such as oral liquid, electuary.Be applicable to control person in middle and old age blood fat height, brain cardiovascular disease is compared evident in efficacy with traditional method.
One piece of patent documentation CN1066786 again of China has reported the reparation technology of long-life and fat-reducing powder.This technology is to choose a certain amount of Rhizoma Polygonati, Fructus Lycii to adopt decocting to boil, with the filtrate evaporation and concentration to the thick paste shape; Get a certain amount of Radix Polygoni Multiflori, Fructus Crataegi, Semen Cassiae again, adopt ethanol to decoct, its filtrate evaporation and concentration is to the thick paste shape.Merge thick paste and add an amount of starch, granulate behind the mixing and sieve, add 0.5% magnesium stearate mixing tabletting, sugar coating forms.This medical instrument has functions such as the liver and the kidney tonifying, nourishing blood for improving eyesight, blood fat reducing, is used for the hepatic and renal YIN deficiency, dizziness, blurred vision, sends out palpus early in vain, hyperlipidemia.
Treat at present as can be seen that the curative effect that the medicine of hyperlipidemia has is low, the course of treatment is long, easily bounce-back; The medicine that has has certain curative effect, and the course of treatment is also short, but toxic, also easily bounce-back.The curative effect of the Chinese drugs agentia of Chinese patent literature treatment hyperlipidemia is also not ideal enough, and the curative effect that has is up to 91.2%.
The objective of the invention is just to be to develop a kind of curative effect height, avirulence, the Chinese drugs agentia of a kind of blood fat reducing that does not rebound after the drug withdrawal.
Another object of the present invention is the process that works out the Chinese drugs agentia of the above-mentioned blood fat reducing of preparation.
The Chinese medicine that mainly contains the following weight ratio in the Chinese drugs agentia material medicine of a kind of blood fat reducing of the present invention: Radix Et Rhizoma Rhei 100-700 part, Rhizoma Curcumae Longae 300-800 part, Radix Curcumae 300-700 part.
In order to strengthen curative effect, in material medicine, also contain the Chinese medicine of following weight ratio: Pollen Typhae 200-700 part, Radix Puerariae 400-600 part.
In order to reach best curative effect, in material medicine, also contain the Chinese medicine of following weight ratio: Radix Salviae Miltiorrhizae 100-500 part, Radix Astragali 100-500 part, Rhizoma Alismatis 300-600 part, Rhizoma Dioscoreae 300-600 part, Radix Trichosanthis 100-500 part, Radix Polygoni Multiflori 200-500 part.
Above-mentioned said part be weight portion, its unit can be restrain, two, unit of weights such as money, jin, kilogram, ton, said medicament is to make capsule for well.
In above-mentioned blood fat reducing Chinese drugs agentia, Radix Et Rhizoma Rhei, Rhizoma Curcumae Longae, Radix Curcumae are three main flavor hypolipidemics.Once above-mentioned three flavor medicines being removed between 5～JIUYUE in 1996 only uses Radix Salviae Miltiorrhizae 500 grams, the Radix Astragali 500 grams, Pollen Typhae 500 grams, Rhizoma Alismatis 500 grams, Rhizoma Dioscoreae 500 grams, Radix Trichosanthis 500 grams, Radix Puerariae 500 grams, Radix Polygoni Multiflori 500 grams to make capsule by former Chinese drugs agentia technology, select 100 routine hyperlipemic patients else and compare test, its method of administration, medication dose, medicine time, criterion of therapeutical effect are identical with former Chinese drugs agentia, and its result is as shown in table 1.
Table 1 100 routine hyperlipemic patients are taken the observation of curative effect that removes three flavor principal agents
| Blood fat situation before taking | Number | Blood fat situation of change after taking medicine one month | Number |
| Triglyceride 300-575mg/dl | 100 | Triglyceride is reduced to 310-432mg/dl | 24 |
| Cholesterol 265-308mg/dl | 11 | Cholesterol is reduced to≤250mg/dl | 3 |
| Triglyceride does not have significant change or undesirable | 76 |
None example of triglyceride reaches healing after taking medicine as can be seen from Table 11 month, effective percentage has only 24%, triglyceride does not have significant change person or undesirable person 76 examples account for 76% after taking medicine 1 month, and hypercholesterolemia patient 11 examples in 100 examples are taken the Chinese drugs agentia capsule that removes three flavor principal agents, have only 3 examples to reduce to normally after 1 month.So after removing three flavor principal agents in the Chinese drugs agentia clinical meaning of hyperlipemic patients is reduced significantly, total effective rate has only 27%.
In October, 96 above-mentioned 100, routine hyperlipemic patients was taken the Chinese drugs agentia capsule that does not remove three flavor principal agents, testing result shows in 100 to be that triglyceride is not reduced to normal person and all is reduced to below the normal value originally after one month, and 8 routine hypercholesterolemia patients also reduce to below the normal value.Proved that three flavor principal agents have significant effect.
The preparation method of the Chinese drugs agentia of a kind of blood fat reducing of the present invention is pressed Radix Et Rhizoma Rhei 100-700 weight portion, Rhizoma Curcumae Longae 300-800 weight portion, Radix Curcumae 300-700 weight powder batching; Rhizoma Curcumae Longae, Radix Curcumae are pulverized altogether, make it become the granule of 20～40 order sizes, the water that adds 6～8 times of amounts of Rhizoma Curcumae Longae, Radix Curcumae gross weight in the Rhizoma Curcumae Longae of pulverizing, turmeric powder boiled 40-60 minute, filtered, the water that in filtering residue, adds 6 times of amounts of Rhizoma Curcumae Longae, Radix Curcumae gross weight, boiled 20-60 minute, and filtered, merge the filtrate after boiling for twice, medicinal residues discard, and the filtrate that merges is concentrated into flowing soaking paste; Radix Et Rhizoma Rhei was pulverized the 100-120 mesh sieve, again with above-mentioned fluid extract mixing, dry (oven dry), the mixture of Radix Et Rhizoma Rhei powder after drying and fluid extract is pulverized the 80-100 mesh sieve formed the mixture powder, the ethanol water that adds an amount of percentage by volume and be 50-70% is a binding agent, made the granule of 20～60 order sizes, oven dry forms the Chinese drugs agentia of blood fat reducing of the present invention.
Add ethanol water as binding agent after, made incapsulate after the granule oven dry of 20～60 order sizes or tabletting for well.In adding behind the water boil of above-mentioned secondary with good good with 4 layers of filtered through gauze.In above-mentioned secondary is dried, be advisable in baking oven, to dry in 50-70 ℃.Ethanol water with percentage by volume 50～70% is a binding agent, and the ethanol water of the percentage by volume 50～70% that is added is 0.1～0.2 with the ratio of the weight of the mixture powder of the back gained that sieves: 1.
In order to strengthen curative effect by Radix Et Rhizoma Rhei 100-700 weight portion, Rhizoma Curcumae Longae 300-800 weight portion, Radix Curcumae 300-700 weight portion, Pollen Typhae 200-700 weight portion, Radix Puerariae 400-600 weight portion batching; Rhizoma Curcumae Longae, Radix Curcumae, Radix Puerariae are pulverized jointly, make it become the granule of 20～40 order sizes, in the Rhizoma Curcumae Longae of pulverizing, Radix Curcumae, powder of Radix Puerariae, add the water that the 6-8 of Rhizoma Curcumae Longae, Radix Curcumae, Radix Puerariae gross weight doubly measures, boiled 40～60 minutes, filter, the water that in filtering residue, adds 6 times of amounts of Rhizoma Curcumae Longae, Radix Curcumae, Radix Puerariae gross weight, boiled 20～60 minutes, and filtered, merge the filtrate after boiling for twice, medicinal residues discard, and the filtrate that merges is concentrated into flowing soaking paste; Radix Et Rhizoma Rhei, Pollen Typhae were pulverized the 100-120 mesh sieve, again with above-mentioned fluid extract mixing, dry, the mixture of the Radix Et Rhizoma Rhei after drying, Pollen Typhae powder and fluid extract is pulverized the 80-100 mesh sieve formed the mixture powder, the ethanol water that adds an amount of percentage by volume and be 50-70% is a binding agent, makes the granule of 20～60 order sizes, roasting oven dry, form blood fat reducing Chinese drugs agentia of the present invention, encapsulated or tabletting.
After secondary adds water boil,, dry, be advisable in baking oven, to dry in 50-70 ℃ at above-mentioned secondary with 4 layers of filtered through gauze.With percentage by volume is that 50～70% ethanol water is a binding agent, and the percentage by volume that is added is 50～70% ethanol water and the ratio of the weight of the mixture powder of the back gained that sieves is 0.1～0.2: 1.
In order to reach best curative effect by Radix Et Rhizoma Rhei 100-700 weight portion, Rhizoma Curcumae Longae 300-800 weight portion, Radix Curcumae 300-700 weight portion, Pollen Typhae 200-700 weight portion, Radix Puerariae 400-600 weight portion, Radix Salviae Miltiorrhizae 100-500 weight portion, Radix Astragali 100-500 weight portion, Rhizoma Alismatis 300-600 weight portion, Rhizoma Dioscoreae 300-600 weight portion, Radix Trichosanthis 100-500 weight portion, Radix Polygoni Multiflori 200-500 weight portion batching; With Rhizoma Curcumae Longae, Radix Curcumae, Radix Puerariae, Radix Salviae Miltiorrhizae, the Radix Astragali, Rhizoma Alismatis, Radix Polygoni Multiflori is pulverized jointly, make it become the granule of 20～40 order sizes, to the Rhizoma Curcumae Longae of pulverizing, Radix Curcumae, Radix Puerariae, Radix Salviae Miltiorrhizae, the Radix Astragali, Rhizoma Alismatis, add Rhizoma Curcumae Longae in the Radix Polygoni Multiflori, Radix Curcumae, Radix Puerariae, Radix Salviae Miltiorrhizae, the Radix Astragali, Rhizoma Alismatis, the water that fleece-flower root total weight 6-8 doubly measures, boiled 40-60 minute, filter, in filtering residue, add Rhizoma Curcumae Longae, Radix Curcumae, Radix Puerariae, Radix Salviae Miltiorrhizae, the Radix Astragali, Rhizoma Alismatis, the water of 6 times of amounts of fleece-flower root total weight, boiled 20-60 minute, filter, merge the filtrate after boiling for twice, medicinal residues discard, the filtrate that merges is concentrated into flowing soaking paste, with Radix Et Rhizoma Rhei, Pollen Typhae, Rhizoma Dioscoreae, Radix Trichosanthis was pulverized the 100-120 mesh sieve, with above-mentioned fluid extract mixing, dried again; The powder of the Radix Et Rhizoma Rhei after drying, Pollen Typhae, Rhizoma Dioscoreae, Radix Trichosanthis and the mixture of fluid extract were pulverized 80-100 mesh sieve formation mixture powder, the ethanol water that adds an amount of percentage by volume and be 50-70% is a binding agent, made the granule of 20～60 order sizes, dry, form the Chinese drugs agentia of blood fat reducing of the present invention, encapsulated or tabletting.Each capsule weighs 0.4 gram, every heavy 0.3 gram.Capsule can be called pure health blood fat capsule.
Above-mentioned all added water yields are 6～8 times, add water in the middle of needing less than 6 times, waste energy when concentrated greater than 8 times.The time of boiling also can be suitable shortening or prolongation, this is that those skilled in the art all know.
Behind water boil with 4 layers of filtered through gauze for well, when above-mentioned all secondaries are dried in baking oven, to dry to good in 50-70 ℃.With percentage by volume is that 50～70% ethanol water is a binding agent, and the ethanol water of the percentage by volume 50～70% that is added is 0.1～0.2 with the ratio of the weight of the mixture powder of the back gained that sieves: 1.
The instructions of taking of medicament capsule of the present invention is taken medicament capsule 1.6 grams of the present invention at every turn, every day three times, send down with warm water.
Medicament capsule acute toxicity test of the present invention is as follows:
One, median lethal dose(LD 50) (LD
50) mensuration:
After the powder water of this medicament capsule mixed, have medicinal residues not irritate stomach by conduit, the water of former medicinal four times of amounts is boiled the extraction secondary in 100 ℃, the extracting liquid filtering post-heating is concentrated into 1: 1 concentration, and promptly every 1ml contains the 1g crude drug.
Used animal is a Kunming kind white mice, body weight 20g ± 2g (Military Medical Science Institute's animal center provides), and male and female half and half are pressed 1ml/20g (quite crude drug 50g/kg), in disposable filling stomach at 8 o'clock in the morning, observe continuously then 7 days, and the result is as follows:
The liquid medicine white mice of medicament capsule system of the present invention is once irritated stomach (1ml/20g), observes after the administration 7 days, and 20 white mice activities, diet are normal, and weight increase (seeing Table 2) is not seen acute toxic reaction and death, LD
50Do not measure.The liquid medicine of the powder system in the oral medicament capsule of the present invention of table 2 white mice influences dosage (g/kg) sex number of animals body weight (X ± SD.g) to body weight
(only)
All 50 ♀ 10 21.2 ± 1.48 26.2 ± 2.10 after the administration before the administration
♂ 10 22.1±1.29 29.9±2.4
♀+♂ 20 21.7±1.42 28.1±2.89
Two, the mensuration of maximum tolerated dose (MTD):
The same LD of animal subject
50Measure, its method is to get 20 of white mice, male and female half and half, as the above-mentioned liquid medicine gastric infusion of making, with its Cmax, the dosage of heap(ed) capacity (volume) (1.0ml/20 gram) is given mice lavage, twice on the one (7 hours at interval), observed 7 days continuously, with the response situation of record animal.Consequently the Cmax of medicament capsule of the present invention and maximum volume (1.0ml/20g) irritate stomach twice in one day for white mice, white mice loose stool behind the filling stomach, recover normal after 24 hours, observed 7 days continuously, 20 none death of white mice, and movable, diet is normal, weight increase (seeing Table 3) is not seen acute toxic reaction.
The liquid medicine of the powder in table 3 white mice one day in the continuous oral medicament capsule of the present invention
Body weight influenced dosage (g/kg) sex number of animals body weight (X ± SD.g)
(only)
All 100 ♀ 10 21.4 ± 1.43 23.1 ± 1.3 after the administration before the administration
♂ 10 22.7±1.25 27.1±1.6
♀+♂ 20 22.1±1.47 25±2.5
In a word, the oral LD of medicament capsule of the present invention
50Show that with MTD mensuration the oral capacity of white mice is respectively 1.0ml/20g, 2.0ml/20g, in one day, once irritate the mode administration that harmonization of the stomach is irritated stomach for twice, calculate dosage and be respectively 50g/kg (LD
50) and 100g/kg (MTD) crude drug.Calculate by kg body weight, 410 times and 820 times of usual amounts every day (0.12g/kg) are equivalent to respectively to be grown up, pressing the system number calculates, 44.1 times and 88.2 times of consumption every day are equivalent to respectively to be grown up, none dead poisoning in 20 white mice 7 days, survey according to statistics Wrightization method, existing more than 99.99% and according to proof, the LD of white mice oral administration
50Must be greater than 50g/kg, MTD is greater than 100g/kg.The proof oral administration is safe.
The curative effect of medicament capsule of the present invention obtains proof from clinic trial.Since nineteen ninety-five December try out in clinical, in November, 1997 totally 320 examples.Male's 257 examples wherein, women's 63 examples, the oldest 74 years old, minimum 38 years old, 48.5 years old mean age.320 examples are one month medicine times, and medication dose is every day three times, take the capsule of 1.6g at every turn.Phlebotomize on an empty stomach respectively to the stipulated time and to detect serum cholesterol and serum triglycerides.Criterion of therapeutical effect is:
1. in required time, the dosage back of taking medicine phlebotomizes on an empty stomach and detects serum cholesterol and serum levels of triglyceride respectively at≤230mg/dl ,≤200mg/dl is for curing.
2. the same at one time dosage of serum cholesterol and serum triglycerides reduces 40mg/dl and 100mg/dl respectively for effectively.
3. by same medicine time, method of administration and dosage, serum cholesterol and serum triglycerides with take medicine before compare lifting be equal to or less than 20mg/dl or with take medicine before to compare no change be invalid.
Table 4 medicament capsule treatment of the present invention hyperlipidemia observation of curative effect table
| Blood fat situation before taking medicine | Number | Blood fat situation of change after taking medicine 1 month | Number |
| Serum triglycerides 350-700mg/dl | 300 | Serum triglycerides is reduced to 130-200mg/dl | 317 |
| Serum cholesterol 260-310mg/dl | 37 | Serum cholesterol is reduced to 166-230mg/dl | 37 |
| Serum triglycerides does not have significant change | 3 |
Illustrate: 37 people's hypercholesterolemia patients are included within 320 examples.
320 routine patients are after taking medicine 1 month as can be seen from Table 4, medication dose is identical, it is invalid that serum triglycerides has only 3 examples to show, account for 0.94% of whole case 320 examples, triglyceride is reduced to 317 people of normal range, 99.06%, the 37 routine hypercholesterolemia patient who accounts for whole case 320 examples all reduces to after taking medicine 1 month normally.
197 routine triglyceride are arranged between 550～700mg/dl in above-mentioned 320 routine patients.Before these patients take medicine the mostly conscious whole body feel nervous, dizzy, insobriety, it is tired to like to feel sleepy.Blood flow is just learned and is checked and to show that all the blood viscosity indexes exceed standard, and after taking medicine 1 month, by blood flow just and triglyceride, cholesterol detection, various indexs all show normally.Above-mentioned 197 routine patients are all conscious, and the whole body is light, and in various degree clearheaded and energetic all arranged, and dizzy symptom most of patients disappears, and has small part patient symptom obviously to improve.
Electrocardiogram is undesired before having 21 examples to take medicine in 320 routine patients, usually it is stuffy etc. to show as chest, flat crouch or the left in bed chest in left side very stuffy, there are 14 routine electrocardiograms normal after taking medicine, disappearance uncomfortable in chest, all the other 7 routine electrocardiograms and subjective symptoms make moderate progress, and illustrate that medicament capsule of the present invention has some improvement to abnormal electrocardiogram by blood fat reducing.
By before the above-mentioned treatment and the data situation after the treatment illustrate that medicament capsule of the present invention just learns the improvement of index by blood fat reducing and blood flow, blood viscosity lowering effectively, improve cardiac and cerebral blood-supply, the control cerebrovascular atherosclerosis, blood circulation promoting, cardiovascular and cerebrovascular disease there is good preventive and therapeutic effect, low price, about 20 yuan of per 100 RMB.
In addition, in above-mentioned 320 routine hyperlipemic patients, just learning inspection by blood flow finds, 28 examples are wherein arranged, the former laboratory values of the factor of taking medicine have in various degree exceed standard the minimum 0.2g% that exceeds standard, the highest 0.6g% that exceeds standard, 0.3～0.4g% person, 13 people that in 28 examples, exceed standard, 0.2g% person 12 people that exceed standard, 3 people of the 0.6g% that exceeds standard.Take medicament capsule of the present invention and all reduce to normal range after one month, be 2-4g% its normal range.
The advantage of blood fat reducing Chinese drugs agentia of the present invention and method for making thereof just is:
1. blood fat reducing Chinese drugs agentia of the present invention is mainly used in the treatment hyperlipidemia, blood circulation promoting and blood stasis dispelling, and promoting QI circulation for relieving depression clear away heart-fire and eliminate the phlegm, good effect, effective percentage height, short treating period, and low price.
2. cure the back and be difficult for knock-on, take case 100 examples that blood fat reducing Chinese drugs agentia of the present invention is cured, test blood fat review result shows after half a year, triglyceride bounce-back 50-100mg/d1 has only 4 examples, 96 examples all in normal value with interior or few high normal value 10～26mg/dl, the result after the check shows that cholesterol index is all below normal value.
3. but blood viscosity lowering, all healing person's blood flow are just learned check and are shown that the whole blood viscosity value all reduces to range of normal value.
4. avirulence does not have the effect of paying.Chinese drugs agentia of the present invention shows by acute toxicity test, oral LD
50Fail to measure maximum tolerated dose＞100g/kg, be equivalent to 410 times of clinical patient consumption white mice.
5. preparation method of the present invention, technology is easy, easy operating, product cost is low.
The present invention is further illustrated with following embodiment, will help the understanding to the present invention and advantage thereof.The present invention is not subjected to the qualification of these embodiment, and protection scope of the present invention is decided by claims.
Embodiment 1
The Chinese drugs agentia that the Chinese drugs agentia of the blood fat reducing of present embodiment is made with the raw material of following weight ratio, Radix Et Rhizoma Rhei 700 grams, Rhizoma Curcumae Longae 600 grams, Radix Curcumae 300 grams.
Its preparation method is by Radix Et Rhizoma Rhei 700 grams, Rhizoma Curcumae Longae 600 grams, Radix Curcumae 300 gram batchings; With Rhizoma Curcumae Longae, Radix Curcumae is pulverized altogether, make it become the granule of 40 order sizes, to the Rhizoma Curcumae Longae of pulverizing, add Rhizoma Curcumae Longae in the turmeric powder, the water of 6 times of amounts of Radix Curcumae gross weight, boiled 50 minutes, filter, in filtering residue, add Rhizoma Curcumae Longae, the water of 6 times of amounts of Radix Curcumae gross weight, boiled 30 minutes, filter, merge the filtrate after boiling for twice, medicinal residues discard, the filtrate that merges is concentrated into flowing soaking paste, Radix Et Rhizoma Rhei was pulverized 110 mesh sieves, with above-mentioned fluid extract mixing, dried again, the mixture of drying back Radix Et Rhizoma Rhei powder and fluid extract is pulverized 100 mesh sieves formed the mixture powder, adding an amount of percentage by volume and be 60% ethanol water is binding agent, makes 20 purpose size particles, and oven dry forms the Chinese drugs agentia of blood fat reducing of the present invention.
Embodiment 2
The Chinese drugs agentia capsule that the Chinese drugs agentia of the blood fat reducing of present embodiment is made with the raw material of following weight ratio, Radix Et Rhizoma Rhei 200 grams, Rhizoma Curcumae Longae 400 grams, Radix Curcumae 700 grams.
Its preparation method is substantially with embodiment 1, and only different is that Rhizoma Curcumae Longae, Radix Curcumae are pulverized altogether, makes its granule that becomes 20 order sizes, and the water to the Rhizoma Curcumae Longae of pulverizing, turmeric powder adding Rhizoma Curcumae Longae, 8 times of amounts of Radix Curcumae gross weight boiled 60 minutes, with 4 layers of filtered through gauze.In filtering residue, add Rhizoma Curcumae Longae, the water of 6 times of amounts of Radix Curcumae gross weight, boiled 50 minutes, with 4 layers of filtered through gauze, merging filtrate, be concentrated into fluid extract, Radix Et Rhizoma Rhei was pulverized 120 mesh sieves, with Radix Et Rhizoma Rhei powder and above-mentioned fluid extract mixing, pulverized 80 mesh sieves in baking oven after 70 ℃ of oven dry, adding percentage by volume and be 70% ethanol water is binding agent, and the ethanol water of the percentage by volume 70% that is added is 0.1: 1 with the ratio of the weight of the back gained mixture powder that sieves, form the granule of 40 order sizes, in baking oven,, form blood fat reducing Chinese drugs agentia of the present invention, incapsulate 50 ℃ of oven dry.
Embodiment 3
The Chinese drugs agentia capsule that the Chinese drugs agentia of the blood fat reducing of present embodiment is made with the raw material of following weight ratio.Radix Et Rhizoma Rhei 400 grams, Rhizoma Curcumae Longae 550 grams, Radix Curcumae 500 grams.
Its preparation method is substantially with embodiment 2.
Embodiment 4
The Chinese drugs agentia capsule that the Chinese drugs agentia of the blood fat reducing of present embodiment is made with the raw material of following weight ratio, Radix Et Rhizoma Rhei 400 grams, Rhizoma Curcumae Longae 700 grams, Radix Curcumae 600 grams, Pollen Typhae 700 grams, Radix Puerariae 600 grams.
Its preparation method is pressed Radix Et Rhizoma Rhei 400 grams, Rhizoma Curcumae Longae 700 grams, Radix Curcumae 600 grams, Pollen Typhae 700 grams, Radix Puerariae 600 gram batchings.Rhizoma Curcumae Longae, Radix Curcumae, Radix Puerariae are pulverized jointly, make it become the granule of 40 order sizes, the water that in the Rhizoma Curcumae Longae of pulverizing, Radix Curcumae, powder of Radix Puerariae, adds 7 times of amounts of Rhizoma Curcumae Longae, Radix Curcumae, Radix Puerariae gross weight, boiled 50 minutes, with 4 layers of filtered through gauze, in filtering residue, add the water of Rhizoma Curcumae Longae, Radix Curcumae, 6 times of amounts of Radix Puerariae gross weight, boiled 30 minutes, with 4 layers of filtered through gauze.Merge the filtrate after boiling for twice, medicinal residues discard.The filtrate that merges is concentrated into flowing soaking paste; Radix Et Rhizoma Rhei, Pollen Typhae were pulverized 120 mesh sieves, again with above-mentioned fluid extract mixing, in baking oven after 70 ℃ of oven dry, pulverized 100 mesh sieves, adding percetage by weight and be 65% ethanol water is binding agent, and the ethanol water of the percentage by volume 65% that is added is 0.15: 1 with the ratio of the weight of the back gained mixture powder that sieves, form the granule of 40 order sizes, 50 ℃ of oven dry, form the Chinese drugs agentia of blood fat reducing of the present invention in baking oven, encapsulated.
Embodiment 5
The Chinese drugs agentia capsule that the Chinese drugs agentia of the blood fat reducing of present embodiment is made with the raw material of following weight ratio.Radix Et Rhizoma Rhei 600 grams, Rhizoma Curcumae Longae 800 grams, Radix Curcumae 700 grams, Pollen Typhae 600 grams, Radix Puerariae 500 grams.
Its preparation method is substantially with embodiment 4, only different is with Rhizoma Curcumae Longae, Radix Curcumae, Radix Puerariae is pulverized jointly, make it cross the granule of 20 order sizes, to the Rhizoma Curcumae Longae of pulverizing, Radix Curcumae, add Rhizoma Curcumae Longae in the powder of Radix Puerariae, Radix Curcumae, the water of 8 times of amounts of Radix Puerariae gross weight, boiled 60 minutes, with 4 layers of filtered through gauze, in filtering residue, add Rhizoma Curcumae Longae, Radix Curcumae, the water of 6 times of amounts of Radix Puerariae gross weight, boiled 40 minutes, and, merged the filtrate after boiling for twice with 4 layers of filtered through gauze, medicinal residues discard, the filtrate that merges is concentrated into flowing soaking paste, Radix Et Rhizoma Rhei, Pollen Typhae was pulverized 120 mesh sieves, again with above-mentioned fluid extract mixing, in baking oven after 55 ℃ of oven dry, pulverized 80 mesh sieves, adding percentage by volume and be 55% ethanol water is binding agent, and the ethanol water of the percentage by volume 55% that is added is 0.2: 1 with the ratio of the weight of the back gained mixture powder that sieves, formed the granule of 40 order sizes, 65 ℃ of oven dry, form blood fat reducing Chinese drugs agentia of the present invention in baking oven, encapsulated.
Embodiment 6
The Chinese drugs agentia capsule that the Chinese drugs agentia of the blood fat reducing of present embodiment is made with the raw material of following weight ratio.Radix Et Rhizoma Rhei 450 grams, Rhizoma Curcumae Longae 550 grams, Radix Curcumae 500 grams, Pollen Typhae 450 grams, Radix Puerariae 500 grams.
Its preparation method is substantially with embodiment 5.
Embodiment 7
The Chinese drugs agentia capsule that the Chinese drugs agentia of the blood fat reducing of present embodiment is made with the raw material of following weight ratio.Radix Et Rhizoma Rhei 700 grams, Rhizoma Curcumae Longae 600 grams, Radix Curcumae 300 grams, Pollen Typhae 700 grams, Radix Puerariae 600 grams, Radix Salviae Miltiorrhizae 500 grams, the Radix Astragali 500 grams, Rhizoma Alismatis 600 grams, Rhizoma Dioscoreae 600 grams, Radix Trichosanthis 400 grams, Radix Polygoni Multiflori 400 grams.
Its preparation method is pressed Radix Et Rhizoma Rhei 700 grams, Rhizoma Curcumae Longae 600 grams, Radix Curcumae 300 grams, Pollen Typhae 700 grams, Radix Puerariae 600 grams, Radix Salviae Miltiorrhizae 500 grams, the Radix Astragali 500 grams, Rhizoma Alismatis 600 grams, Rhizoma Dioscoreae 600 grams, Radix Trichosanthis 400 grams, Radix Polygoni Multiflori 400 gram batchings; With Rhizoma Curcumae Longae, Radix Curcumae, Radix Puerariae, Radix Salviae Miltiorrhizae, the Radix Astragali, Rhizoma Alismatis, Radix Polygoni Multiflori is pulverized jointly, make it become the granule of 40 order sizes, to the Rhizoma Curcumae Longae of pulverizing, Radix Curcumae, Radix Puerariae, Radix Salviae Miltiorrhizae, the Radix Astragali, Rhizoma Alismatis, add Rhizoma Curcumae Longae in the Radix Polygoni Multiflori powder, Radix Curcumae, Radix Puerariae, Radix Salviae Miltiorrhizae, the Radix Astragali, Rhizoma Alismatis, the water of 8 times of amounts of fleece-flower root total weight, boiled 50 minutes, with 4 layers of filtered through gauze, in filtering residue, add Rhizoma Curcumae Longae, Radix Curcumae, Radix Puerariae, Radix Salviae Miltiorrhizae, the Radix Astragali, Rhizoma Alismatis, the water of 6 times of amounts of fleece-flower root total weight, boiled 40 minutes, with 4 layers of filtered through gauze, merge the filtrate after boiling for twice, medicinal residues discard, the filtrate that merges is concentrated into flowing soaking paste, with Radix Et Rhizoma Rhei, Pollen Typhae, Rhizoma Dioscoreae, Radix Trichosanthis was pulverized 120 mesh sieves, again with above-mentioned fluid extract mixing, in baking oven after 70 ℃ of oven dry, with the Radix Et Rhizoma Rhei after the oven dry, Pollen Typhae, Rhizoma Dioscoreae, the powder of Radix Trichosanthis and the mixture of fluid extract were pulverized 100 mesh sieves and were formed the mixture powder, the ethanol water of adding 70% is a binding agent, the ethanol water of the percentage by volume 70% that is added is 0.15: 1 with the ratio of the weight of the back gained mixture powder that sieves, form the granule of 40 order sizes, in baking oven 50 ℃ of oven dry, form the Chinese drugs agentia of blood fat reducing of the present invention, encapsulated, each capsule weighs 0.4 gram.
Embodiment 8
The Chinese drugs agentia capsule that the Chinese drugs agentia of the blood fat reducing of present embodiment is made with the raw material of following weight ratio.Radix Et Rhizoma Rhei 200 grams, Rhizoma Curcumae Longae 400 grams, Radix Curcumae 700 grams, Pollen Typhae 600 grams, Radix Puerariae 500 grams, Radix Salviae Miltiorrhizae 350 grams, the Radix Astragali 350 grams, Rhizoma Alismatis 500 grams, Rhizoma Dioscoreae 500 grams, Radix Trichosanthis 200 grams, Radix Polygoni Multiflori 250 grams.
Its preparation method is substantially with embodiment 7.
Embodiment 9
The Chinese drugs agentia capsule that the Chinese drugs agentia of the blood fat reducing of present embodiment is made with the raw material of following weight ratio.Radix Et Rhizoma Rhei 400 grams, Rhizoma Curcumae Longae 550 grams, Radix Curcumae 500 grams, Pollen Typhae 450 grams, Radix Puerariae 500 grams, Radix Salviae Miltiorrhizae 300 grams, the Radix Astragali 300 grams, Rhizoma Alismatis 450 grams, Rhizoma Dioscoreae 450 grams, Radix Trichosanthis 500 grams, Radix Polygoni Multiflori 500 grams.
Its preparation method is substantially with embodiment 7.
Claims (10)
1. the Chinese drugs agentia of a blood fat reducing is characterized in that mainly containing in the material medicine Chinese medicine of following weight ratio: 100～700 parts of Radix Et Rhizoma Rhei, 300～800 parts in Rhizoma Curcumae Longae, 300～700 parts of Radix Curcumaes.
2. according to the Chinese drugs agentia of claim 1, it is characterized in that being also to contain in the material medicine Chinese medicine of following weight ratio: 200～700 parts of Pollen Typhaes, 400～600 parts of Radix Puerariaes.
3. according to the Chinese drugs agentia of claim 2, it is characterized in that being also to contain in the material medicine Chinese medicine of following weight ratio: Radix Salviae Miltiorrhizae 100-500 part, Radix Astragali 100-500 part, Rhizoma Alismatis 300-600 part, Rhizoma Dioscoreae 300-600 part, Radix Trichosanthis 100-500 part, Radix Polygoni Multiflori 200-500 part.
4. the preparation method of the Chinese drugs agentia of a blood fat reducing is characterized in that,
1) press Radix Et Rhizoma Rhei 100-700 weight portion, Rhizoma Curcumae Longae 300-800 weight portion, Radix Curcumae 300-700 weight portion batching,
2) Rhizoma Curcumae Longae, Radix Curcumae are pulverized altogether, make it become the granule of 20-40 order size, the water that in the Rhizoma Curcumae Longae of pulverizing, turmeric powder, adds 6～8 times of amounts of Rhizoma Curcumae Longae, Radix Curcumae gross weight, boiled 40～60 minutes, and filtered, in filtering residue, add the water of 6 times of amounts of Rhizoma Curcumae Longae, Radix Curcumae gross weight, boiled 20-60 minute, filter merging filtrate
3) filtrate that merges is concentrated into flowing soaking paste,
4) Radix Et Rhizoma Rhei was pulverized the 100-120 mesh sieve again with above-mentioned fluid extract mixing, dry, the mixture of Radix Et Rhizoma Rhei powder after drying and fluid extract is pulverized the 80-100 mesh sieve formed the mixture powder, the ethanol water that adds an amount of percentage by volume 50～70% is the granule that binding agent was made 20～60 order sizes, and oven dry forms the Chinese drugs agentia of blood fat reducing.
5. the preparation method of the Chinese drugs agentia of claim 2 is characterized in that,
1) press Radix Et Rhizoma Rhei 100-700 weight portion, Rhizoma Curcumae Longae 300-800 weight portion, Radix Curcumae 300-700 weight portion, Pollen Typhae 200-700 weight portion, Radix Puerariae 400～600 weight portions batching,
2) Rhizoma Curcumae Longae, Radix Curcumae, Radix Puerariae are pulverized jointly, make it become the granule of 20-40 order size, in the Rhizoma Curcumae Longae of pulverizing, Radix Curcumae, powder of Radix Puerariae, add the water that the 6-8 of Rhizoma Curcumae Longae, Radix Curcumae, Radix Puerariae gross weight doubly measures, boiled 40～60 minutes, and filtered, in filtering residue, add the water of 6 times of amounts of Rhizoma Curcumae Longae, Radix Curcumae, Radix Puerariae gross weight, boiled 20-60 minute, filter merging filtrate
3) Radix Et Rhizoma Rhei, Pollen Typhae were pulverized the 100-120 mesh sieve, again with the fluid extract mixing, dry, the mixture of the Radix Et Rhizoma Rhei after drying, Pollen Typhae powder and fluid extract is pulverized the 80-100 mesh sieve formed the mixture powder, the ethanol water that adds an amount of percentage by volume and be 50-70% is a binding agent, made the granule of 20～60 order sizes, dried.
6. the preparation method of the Chinese drugs agentia of claim 3 is characterized in that,
1) presses Radix Et Rhizoma Rhei 100-700 weight portion, Rhizoma Curcumae Longae 300-800 weight portion, Radix Curcumae 300-700 weight portion, Pollen Typhae 200-700 weight portion, Radix Puerariae 400-600 weight portion, Radix Salviae Miltiorrhizae 100-500 weight portion, Radix Astragali 100-500 weight portion, Rhizoma Alismatis 300-600 weight portion, Rhizoma Dioscoreae 300-600 weight portion, Radix Trichosanthis 100-500 weight portion, Radix Polygoni Multiflori 200-500 weight portion batching
2) with Rhizoma Curcumae Longae, Radix Curcumae, Radix Puerariae, Radix Salviae Miltiorrhizae, the Radix Astragali, Rhizoma Alismatis, Radix Polygoni Multiflori is pulverized jointly, make it become the granule of 20-40 order size, to the Rhizoma Curcumae Longae of pulverizing, Radix Curcumae, Radix Puerariae, Radix Salviae Miltiorrhizae, the Radix Astragali, Rhizoma Alismatis, add Rhizoma Curcumae Longae in the Radix Polygoni Multiflori, Radix Curcumae, Radix Puerariae, Radix Salviae Miltiorrhizae, the Radix Astragali, Rhizoma Alismatis, the water that fleece-flower root total weight 6-8 doubly measures, boiled 40-60 minute, filter, in filtering residue, add Rhizoma Curcumae Longae, Radix Curcumae, Radix Puerariae, Radix Salviae Miltiorrhizae, the Radix Astragali, Rhizoma Alismatis, the water of 6 times of amounts of fleece-flower root total weight, boiled 20-60 minute, filter, merging filtrate
3) Radix Et Rhizoma Rhei, Pollen Typhae, Rhizoma Dioscoreae, Radix Trichosanthis were pulverized the 100-120 mesh sieve, again with above-mentioned fluid extract mixing, dry, the powder of the Radix Et Rhizoma Rhei after drying, Pollen Typhae, Radix Trichosanthis and the mixture of fluid extract were pulverized 80-100 mesh sieve formation mixture powder, the ethanol water that adds an amount of percentage by volume and be 50-70% is a binding agent, made the granule of 20～60 order sizes, dried.
7. according to the preparation method of the Chinese drugs agentia of claim 4, it is characterized in that the ethanol water of the percentage by volume 50-70% that is added is 0.1～0.2 with the ratio of the weight of the mixture powder of the back gained that sieves: 1.
8. according to the preparation method of the Chinese drugs agentia of claim 5, it is characterized in that the ethanol water of the percentage by volume 50-70% that is added is 0.1～0.2 with the ratio of the weight of the mixture powder of the back gained that sieves: 1.
9. according to the preparation method of the Chinese drugs agentia of claim 6, it is characterized in that the ethanol water of the percentage by volume 50-70% that is added is 0.1～0.2 with the ratio of the weight of the mixture powder of the back gained that sieves: 1.
10. according to the preparation method of the Chinese drugs agentia of claim 4 or 5 or 6, it is characterized in that, when secondary is dried, dry in 50-70 ℃.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 98100188 CN1063077C (en) | 1998-02-06 | 1998-02-06 | Traditional Chinese medicine composition for lowering blood-lipid, and method for preparing same |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 98100188 CN1063077C (en) | 1998-02-06 | 1998-02-06 | Traditional Chinese medicine composition for lowering blood-lipid, and method for preparing same |
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| CN1063077C true CN1063077C (en) | 2001-03-14 |
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| CN102488128B (en) * | 2011-12-02 | 2013-09-25 | 马松江 | Food composition having function of assisting in depressing blood-fat and preparation method thereof |
| CN104056184A (en) * | 2013-03-22 | 2014-09-24 | 曹昌银 | Traditional Chinese medicine health care composition for reducing blood lipid |
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