CN1289111C - Medicine for lowering blood lipid and softening blood vessel and its preparing method - Google Patents
Medicine for lowering blood lipid and softening blood vessel and its preparing method Download PDFInfo
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- CN1289111C CN1289111C CN 200310119373 CN200310119373A CN1289111C CN 1289111 C CN1289111 C CN 1289111C CN 200310119373 CN200310119373 CN 200310119373 CN 200310119373 A CN200310119373 A CN 200310119373A CN 1289111 C CN1289111 C CN 1289111C
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- fat reducing
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- vessel softening
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Abstract
The present invention discloses a medicine for lowering blood fat and softening blood vessels and a preparing method thereof. The medicine is a medicinal preparation proportionally prepared from semen cassiae, hawthorn, lotus leaf and prepared fleeceflower root as raw materials by using the preparing methods of water extraction, pulverization, etc., and has the functions of lowering blood fat, softening blood vessels, strengthening the blood circulation of coronary arteries, improving the sensitivity of cardiac muscles to cardiac glycoside and resisting arrhythmia and hyperlipemia. The therapeutic effect of the medicine is obvious.
Description
Technical field
The present invention relates to blood fat reducing, vessel softening, be used to strengthen blood circulation coronarius, improve the sensitivity of cardiac muscle, medicine of a kind of blood fat reducing vessel softening of arrhythmia and hyperlipidemia and preparation method thereof the cardiotonic glycoside effect.
Technical background
The research work of using the treatment by Chinese herbs hyperlipidemia in recent years grows a lot, the research data of Chinese medicine blood fat reducing has a lot, mainly contain periodical Tianjin traditional Chinese medical science nineteen ninety, (4) document serial number 92002669 discloses " clinical observation on the therapeutic effect of Chinese medicine fat reducing pill treatment hyperlipoproteinemia " its prescription: Fructus Crataegi 100g, Semen Cassiae, Folium Nelumbinis, the Radix Polygoni Multiflori, Radix Salviae Miltiorrhizae, each 60g medicine-feeding of Rhizoma Alismatis are fine flour altogether, practicing honey is ball, through 103 routine hyperlipemic patients checkings, total effective rate 89.22%.But its component flavour of a drug are more, the cost height.
Summary of the invention:
The object of the present invention is to provide through clinical verification evident in efficacy with medicine existing prescription component, a kind of blood fat reducing vessel softening that proportioning is different and preparation method thereof.Reduce component and reduce cost, the present invention takes following technical scheme for this reason: a kind of medicine of blood fat reducing vessel softening is characterized in that it is the medicament that the following weight proportion raw material is made:
700 parts-850 parts of 30 portions of-45 portions of Fructus Crataegis of Semen Cassiae
30 parts-45 parts of 100 parts of-130 parts of Radix Polygoni Multiflori Preparatas of Folium Nelumbinis
According to the medicine of above-mentioned blood fat reducing vessel softening, it is characterized in that its best proportioning is:
800 parts of 40 portions of Fructus Crataegis of Semen Cassiae
40 parts of 120 parts of Radix Polygoni Multiflori Preparatas of Folium Nelumbinis
According to the medicine of above-mentioned blood fat reducing vessel softening, it is characterized in that said medicament is the above a dosage form of any pharmaceutics.
According to the medicine of described blood fat reducing vessel softening, it is characterized in that said medicament is pill, capsule, tablet, granule.
According to the process for preparing medicine of described blood fat reducing, vessel softening, it is characterized in that above four flavors, add 480 parts of white sugar, be ground into fine powder 100 orders that sieve, mixing; In the GMP cleaning shop, above-mentioned raw materials is mixed in proportion, add 1036-1332 part refined honey, make blood fat reducing, vessel softening honeyed pill.
According to the process for preparing medicine of described blood fat reducing vessel softening, it is characterized in that taking by weighing Semen Cassiae, Fructus Crataegi, Radix Polygoni Multiflori Preparata, Folium Nelumbinis and add 10 times of water gagings, reflux, extract, 2 times, each 2 hours, filter, when filtrate decompression is concentrated into 80 ℃ of thick paste shapes, relative density is 1.28, and is standby; The water of said extracted gained is carried thick paste, and 50～60 ℃ of drying under reduced pressure were pulverized 100 mesh sieves and were got fine powder.Use 70% alcohol granulation, cross 18 mesh sieves, 50～60 ℃ of dryings are crossed 18 mesh sieve granulate, and the hard capsule of packing into promptly gets blood fat reducing, vessel softening capsule.
According to the process for preparing medicine of described blood fat reducing vessel softening, it is characterized in that taking by weighing Semen Cassiae, Fructus Crataegi, Radix Polygoni Multiflori Preparata, Folium Nelumbinis and add 10 times of water gagings, reflux, extract, 2 times, each 2 hours, filter, when filtrate decompression is concentrated into 80 ℃ of thick paste shapes, relative density is 1.28, and is standby; The water of said extracted gained is carried thick paste, and 50～60 ℃ of drying under reduced pressure were pulverized 100 mesh sieves and were got fine powder.Use 65% alcohol granulation, cross 18 mesh sieves, 50～60 ℃ of dryings are crossed 18 mesh sieve granulate, promptly get blood fat reducing, vessel softening granule.
According to the preparation method of the medicine of described blood fat reducing vessel softening, it is characterized in that taking by weighing Semen Cassiae, Fructus Crataegi, Radix Polygoni Multiflori Preparata, Folium Nelumbinis and add 10 times of water gagings, reflux, extract, 2 times, each 2 hours, filter, when filtrate decompression is concentrated into 80 ℃ of thick paste shapes, relative density is 1.28, and is standby; The water of said extracted gained is carried thick paste, add 80 parts of starch, 100 parts of microcrystalline Cellulose, mixing, 50～60 ℃ of dryings were pulverized 100 mesh sieves and were got fine powder, added 30 parts of CMC-Ca, mixing is used 70% alcohol granulation, crosses 18 mesh sieves, 50～60 ℃ of dryings, cross 18 mesh sieve granulate, add 4 parts of magnesium stearate, mixing, tabletting promptly gets blood fat reducing vessel softening sheet.
Preparation method according to the medicine of described blood fat reducing vessel softening, it is characterized in that taking by weighing Semen Cassiae, Fructus Crataegi, Radix Polygoni Multiflori Preparata, Folium Nelumbinis and add 10 times of water gagings, reflux, extract, 2 times, each 2 hours, filter, when filtrate decompression is concentrated into 80 ℃ of thick paste shapes, relative density is 1.28, drying under reduced pressure was pulverized 100 mesh sieves and got fine powder, and was standby; To stir evenly after 0.5 part in lecithin, 500 parts of salad oils, 60 parts of heat fused of Cera Flava, filter, add medicated powder when being cooled to 40 ℃, emulsifying is also crossed colloid mill, makes blood fat reducing, vessel softening soft capsule.
Through Tianjin peace hospital, Tianjin waterside pavilion hospital, "four news" (new ideas cotton mill, Tianjin health station, Tangshan City's pottery hospital, hospital of Langfang petroleum pipeline office blood fat reducing vessel softening ball (claiming XUEZHINING WAN again) is done clinical 250 routine curative effect statistics altogether by 250 routine clinical trial XUEZHINING from 1980 to 1981 and sees Table 1:
Table 1
| Organization | The example number | Produce effects | Percentage ratio | Effectively | Percentage ratio | Invalid | Percentage ratio |
| Tianjin peace hospital | 44 | 25 | 57％ | 12 | 27％ | 7 | 16％ |
| Tianjin waterside pavilion hospital | 85 | 47 | 55％ | 35 | 41％ | 3 | 4％ |
| "four news" (new ideas cotton mill, Tianjin health station | 8 | 3 | 37.5％ | 4 | 50％ | 1 | 12.5％ |
| Tangshan City pottery hospital | 20 | 5 | 25％ | 11 | 55％ | 4 | 20％ |
| Tangshan City first hospital | 31 | 21 | 68％ | 7 | 22％ | 3 | 10％ |
| Langfang hospital of petroleum pipeline office | 62 | 35 | 56％ | 18 | 29％ | 9 | 15％ |
| Amount to | 250 | 136 | 54.4％ | 87 | 34.8％ | 27 | 10.8％ |
Find out 250 routine total effective rates 89.2% from table, test shows, evident in efficacy treatment cholesterol, triglyceride disease, it is a kind of determined curative effect, easy to carry be used to strengthen blood circulation coronarius, improve the sensitivity of cardiac muscle the cardiotonic glycoside effect, arrhythmia and hyperlipidemia Chinese medicine preparation, the few two flavor medicines of relatively existing prescription reduce cost and have guaranteed the higher effective rate.
Enumerate " peaceful hospital XUEZHINING observation of curative effect material " that peace hospital in Tianjin does totally 44 examples here, see Table 2:
Table 2
| Curative effect | The example number | Percentage ratio | Remarks |
| Produce effects | 25 | 57％ | |
| Effectively | 12 | 27％ | |
| Invalid | 7 | 16％ | |
| Amount to | 44 | 100％ |
Find out 44 routine total effective rates 84% from table.XUEZHINING treatment hyperlipidemia 44 routine clinical observation on the therapeutic effect: coronary heart disease is a kind of common frdquently encountered disease, and its pathogenic factor is more, but wherein one of chief reason and related to blood fat.We obtain preliminary effect from year February in March, 1980 to 1981 with XUEZHINING treatment hyperlipidemia 44 examples, now the clinical observation on the therapeutic effect result are reported as follows:
One, physical data:
Among the 44 routine patients, male's 26 examples, women's 18 examples, minimum 21 years old of age, the oldest 70 years old, the mean age 48, the year, the cadre accounts for 27 people, workman 16 people, housewife 1 people, coronary heart disease 16 people, coronary heart disease of hypertension 9 people, hyperlipidemia 17 people, chronic hepatitis 1 people.
Two, prescription is formed and method of administration:
XUEZHINING Main Ingredients and Appearance: refined honey balls such as Fructus Crataegi, the Radix Polygoni Multiflori, Folium Nelumbinis, white sugar, the heavy 4.5g of every ball obeys secondary every day, obeys 4 balls at every turn, at period in a medicine, withdraw in other, western lipid lowerers, diet is as usual, take medicine before the chemical examination blood fat, so that in contrast, every clothes one month were a course of treatment, and the check blood fat is once observed contrast before and after taking medicine.
Three, therapeutic evaluation standard:
I chemically examine normal value, cholesterol peak 220mg% by institute's blood fat.
(example) what * *, the woman, 54 years old,, main for my nurse of institute (retirement) has hypertension at ordinary times, presses coronary heart disease
Tell dizziness, feel suffocated, precordial pain, what on October 13rd, 80 began to take XUEZHINING, in the preceding chemical examination of taking medicine: three acid glycerols
1000mg%, chemically examine after the January of taking medicine: three acid glycerol 365mg%, chemical examination after taking medicine two months: it is a lot of that three acid glycerol 500mg%, (during this period because of having eaten the food of some chickens, shrimp and so on) but the inferior medicine of clothes generally speaking descend, and symptom significantly alleviates.
(example) Lee * *, man, 47 years old, work unit: peaceful hospital, professional laboratorian, main suit's dizziness, hands swelling, chemical examination: three acid glycerol 170mg%, chemical examination three acid glycerol 95mg% after the January of taking medicine, dizzy, hands swelling transference cure.Period in a medicine is not obeyed in other, western lipid lowerers.
Below be that 44 examples are taken XUEZHINING therapeutic effect statistical table 3
Table 3 is that 44 examples are taken XUEZHINING therapeutic effect statistics
| Sequence number | The example number | Cholesterol decline effect number | The example number | Triglyceride decline effect number | ||||||
| Produce effects | Effectively | Invalid | Decline % | Produce effects | Effectively | Invalid | Decline % | |||
| 1 | 23 | 13 | 4 | 6 | 74 | 26 | 13 | 6 | 7 | 73 |
| 2 | 16 | 2 | 14 | 100 | 14 | 13 | 1 | 100 | ||
| 3 | 3 | 1 | 2 | 33 | 2 | 1 | 1 | 50 | ||
| 4 | 1 | 1 | - | 1 | 1 | |||||
| 5 | 1 | 1 | - | 1 | 1 | |||||
| Amount to | 44 | 16 | 18 | 10 | 77 | 44 | 27 | 7 | 10 | 77 |
Four, side effect: oral non-evident effect, have only a few patients reaction that gastric acid is arranged, still advise all have serious gastric ulcer patient Ying Shen with or need not.The routine number that we observe is less, and the time is shorter, from the observation of curative effect that 44 routine patients take medicine, thinks that XUEZHINING treatment hyperlipemia curative effect is a medicine preferably, and lipid-lowering effect is more remarkable.If allow patient eat the food of increase blood fat less at period in a medicine, the effect of blood fat reducing can be better.Good than other fat-reducing medicament lipid-lowering effects, it is fast to produce effects, and has no side effect, so suggestion is put into operation.
Other clinical datas in 250 examples see attached Tianjin waterside pavilion hospital " XUEZHINING treatment hyperlipemia 85 routine observation of curative effect " for details; "four news" (new ideas cotton mill, Tianjin health station " XUEZHINING clinical observation on the therapeutic effect table (8) example "; Tangshan City pottery hospital's " XUEZHINING 20 routine clinical observations "; Tangshan City first hospital " 31 routine clinical observation on the therapeutic effect "; Hospital of pipeline office of Langfang petroleum department " XUEZHINING treatment hyperlipemia 50 routine clinical observation efficacy analysis ".
Description of drawings
Fig. 1 is a blood fat reducing vessel softening ball process chart.
Fig. 2 is a blood fat reducing vessel softening hard capsule process chart.
Fig. 3 is a blood fat reducing vessel softening granule process chart.
Fig. 4 is a blood fat reducing vessel softening blade technolgy flow chart.
Fig. 5 is a blood fat reducing vessel softening soft capsule process chart.
The specific embodiment
The preparation of embodiment 1 blood fat reducing vessel softening ball:
Prescription:
800 parts of 40 portions of Fructus Crataegis of Semen Cassiae
40 parts of 120 parts of Radix Polygoni Multiflori Preparatas of Folium Nelumbinis
Preparation method:
More than four flavors, add 480 parts of white sugar, be ground into fine powder 100 orders that sieve, mixing.
In the GMP cleaning shop, above-mentioned raw materials is mixed in proportion, add 1036-1332 part refined honey, make the big honeyed pills of the heavy 9g of every ball.
The preparation of embodiment 2 blood fat reducing vessel softening hard capsules:
Prescription:
800 parts of 40 portions of Fructus Crataegis of Semen Cassiae
40 parts of 120 parts of Radix Polygoni Multiflori Preparatas of Folium Nelumbinis
Preparation method:
One: extract
Take by weighing Semen Cassiae, Fructus Crataegi, Radix Polygoni Multiflori Preparata, Folium Nelumbinis and add 10 times of water gagings, reflux, extract, 2 times, each 2 hours, filter, filtrate decompression is concentrated into thick paste shape (80 ℃ time, relative density is 1.28), and is standby.
Two: preparation
The water of said extracted gained is carried thick paste, and 50～60 ℃ of drying under reduced pressure were pulverized 100 mesh sieves and were got fine powder.Use 70% alcohol granulation, cross 18 mesh sieves, 50～60 ℃ of dryings are crossed 18 mesh sieve granulate, and encapsulated (tolerant 0.33 gram of every intragranular), promptly.
The particulate preparation of embodiment 3 blood fat reducing vessel softeninges:
Prescription:
800 parts of 40 portions of Fructus Crataegis of Semen Cassiae
40 parts of 120 parts of Radix Polygoni Multiflori Preparatas of Folium Nelumbinis
Preparation method:
One: extract
Take by weighing Semen Cassiae, Fructus Crataegi, Radix Polygoni Multiflori Preparata, Folium Nelumbinis and add 10 times of water gagings, reflux, extract, 2 times, each 2 hours, to filter, filtrate decompression is concentrated into thick paste shape (80 ℃ time, relative density is 1.28), and is standby.
Two: preparation
The water of said extracted gained is carried thick paste, and 50～60 ℃ of drying under reduced pressure were pulverized 100 mesh sieves and were got fine powder.Use 65% alcohol granulation, cross 18 mesh sieves, 50～60 ℃ of dryings are crossed 18 mesh sieve granulate, promptly get blood fat reducing vessel softening granule.
The preparation of embodiment 4 blood fat reducing vessel softening sheets:
Prescription:
800 parts of 40 portions of Fructus Crataegis of Semen Cassiae
40 parts of 120 parts of Radix Polygoni Multiflori Preparatas of Folium Nelumbinis
Preparation method:
One: extract
Take by weighing Semen Cassiae, Fructus Crataegi, Radix Polygoni Multiflori Preparata, Folium Nelumbinis and add 10 times of water gagings, reflux, extract, 2 times, each 2 hours, to filter, filtrate decompression is concentrated into thick paste shape (80 ℃ time, relative density is 1.28), and is standby.
Two: preparation
The water of said extracted gained is carried thick paste, add 80 parts of starch, 100 parts of microcrystalline Cellulose, mixing, 50～60 ℃ of dryings were pulverized 100 mesh sieves and were got fine powder, added 30 parts of CMC-Ca, mixing is used 70% alcohol granulation, crosses 18 mesh sieves, 50～60 ℃ of dryings, cross 18 mesh sieve granulate, add 4 parts of magnesium stearate, mixing, tabletting (every 0.33 gram) promptly gets blood fat reducing vessel softening sheet.
Embodiment 4 blood fat reducing vessel softening preparation of soft capsule:
Prescription:
800 parts of 40 portions of Fructus Crataegis of Semen Cassiae
40 parts of 120 parts of Radix Polygoni Multiflori Preparatas of Folium Nelumbinis
Preparation method:
One: extract
Take by weighing Semen Cassiae, Fructus Crataegi, Radix Polygoni Multiflori Preparata, Folium Nelumbinis and add 10 times of water gagings, reflux, extract, 2 times, each 2 hours, to filter, filtrate decompression is concentrated into thick paste shape (80 ℃ time, relative density is 1.28), and drying under reduced pressure was pulverized 100 mesh sieves and got fine powder, and was standby.
Two: preparation
To stir evenly after 0.5 part in lecithin, 500 parts of salad oils, 60 parts of heat fused of Cera Flava, filter, add medicated powder when being cooled to 40 ℃, emulsifying is also crossed colloid mill, makes blood fat reducing vessel softening soft capsule (every 0.5g).
Claims (4)
1, a kind of process for preparing medicine of blood fat reducing vessel softening, it is by the following weight proportioning: the raw material of 40 parts of Semen Cassiaes, 800 parts of Fructus Crataegis, 120 parts on Folium Nelumbinis, 40 parts of Radix Polygoni Multiflori Preparatas, it is characterized in that taking by weighing Semen Cassiae, Fructus Crataegi, Radix Polygoni Multiflori Preparata, Folium Nelumbinis and add 10 times of water gagings, reflux, extract, 2 times, each 2 hours, filter, when filtrate decompression is concentrated into 80 ℃ of thick paste shapes, relative density is 1.28, and is standby; The water of said extracted gained is carried thick paste, and 50～60 ℃ of drying under reduced pressure were pulverized 100 mesh sieves and were got fine powder; Use 70% alcohol granulation, cross 18 mesh sieves, 50～60 ℃ of dryings are crossed 18 mesh sieve granulate, and the hard capsule of packing into promptly gets blood fat reducing vessel softening capsule.
2, a kind of process for preparing medicine of blood fat reducing vessel softening, it is by the following weight proportioning: the raw material of 40 parts of Semen Cassiaes, 800 parts of Fructus Crataegis, 120 parts on Folium Nelumbinis, 40 parts of Radix Polygoni Multiflori Preparatas, it is characterized in that taking by weighing Semen Cassiae, Fructus Crataegi, Radix Polygoni Multiflori Preparata, Folium Nelumbinis and add 10 times of water gagings, reflux, extract, 2 times, each 2 hours, filter, when filtrate decompression is concentrated into 80 ℃ of thick paste shapes, relative density is 1.28, and is standby; The water of said extracted gained is carried thick paste, and 50～60 ℃ of drying under reduced pressure were pulverized 100 mesh sieves and were got fine powder; Use 65% alcohol granulation, cross 18 mesh sieves, 50～60 ℃ of dryings are crossed 18 mesh sieve granulate, promptly get blood fat reducing vessel softening granule.
3, a kind of process for preparing medicine of blood fat reducing vessel softening, it is by the following weight proportioning: the raw material of 40 parts of Semen Cassiaes, 800 parts of Fructus Crataegis, 120 parts on Folium Nelumbinis, 40 parts of Radix Polygoni Multiflori Preparatas, it is characterized in that taking by weighing Semen Cassiae, Fructus Crataegi, Radix Polygoni Multiflori Preparata, Folium Nelumbinis and add 10 times of water gagings, reflux, extract, 2 times, each 2 hours, filter, when filtrate decompression is concentrated into 80 ℃ of thick paste shapes, relative density is 1.28, and is standby; The water of said extracted gained is carried thick paste, add 80 parts of starch, 100 parts of microcrystalline Cellulose, mixing, 50～60 ℃ of dryings were pulverized 100 mesh sieves and were got fine powder, added CMC-Ca30 part, mixing is used 70% alcohol granulation, crosses 18 mesh sieves, 50～60 ℃ of dryings, cross 18 mesh sieve granulate, add 4 parts of magnesium stearate, mixing, tabletting promptly gets blood fat reducing vessel softening sheet.
4, a kind of process for preparing medicine of blood fat reducing vessel softening, it is by the following weight proportioning: the raw material of 40 parts of Semen Cassiaes, 800 parts of Fructus Crataegis, 120 parts on Folium Nelumbinis, 40 parts of Radix Polygoni Multiflori Preparatas, it is characterized in that taking by weighing Semen Cassiae, Fructus Crataegi, Radix Polygoni Multiflori Preparata, Folium Nelumbinis and add 10 times of water gagings, reflux, extract, 2 times, each 2 hours, filter, when filtrate decompression was concentrated into 80 ℃ of thick paste shapes, relative density was 1.28, drying under reduced pressure, pulverize 100 mesh sieves and got fine powder, standby; To stir evenly after 0.5 part in lecithin, 500 parts of salad oils, 60 parts of heat fused of Cera Flava, filter, add medicated powder when being cooled to 40 ℃, emulsifying is also crossed colloid mill, makes blood fat reducing vessel softening soft capsule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200310119373 CN1289111C (en) | 2003-12-23 | 2003-12-23 | Medicine for lowering blood lipid and softening blood vessel and its preparing method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200310119373 CN1289111C (en) | 2003-12-23 | 2003-12-23 | Medicine for lowering blood lipid and softening blood vessel and its preparing method |
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| Publication Number | Publication Date |
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| CN1554408A CN1554408A (en) | 2004-12-15 |
| CN1289111C true CN1289111C (en) | 2006-12-13 |
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| CN 200310119373 Expired - Lifetime CN1289111C (en) | 2003-12-23 | 2003-12-23 | Medicine for lowering blood lipid and softening blood vessel and its preparing method |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101653496B (en) * | 2009-09-09 | 2012-05-23 | 天津中新药业集团股份有限公司达仁堂制药厂 | Discrimination method of traditional Chinese medicine Xuezhining pill |
| CN104082748A (en) * | 2014-07-23 | 2014-10-08 | 凯泽（武汉）健康管理有限公司 | Functional food for conditioning lipid balance |
| CN104173495A (en) * | 2014-08-01 | 2014-12-03 | 通化新东日药业股份有限公司 | Jiangzhining granule and preparation method thereof |
| CN117180340B (en) * | 2023-11-08 | 2024-04-26 | 吉林华康食元生物科技有限公司 | Composition for reducing blood fat and preparation method and application thereof |
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