CN104173495A - Jiangzhining granule and preparation method thereof - Google Patents
Jiangzhining granule and preparation method thereof Download PDFInfo
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- CN104173495A CN104173495A CN201410377468.2A CN201410377468A CN104173495A CN 104173495 A CN104173495 A CN 104173495A CN 201410377468 A CN201410377468 A CN 201410377468A CN 104173495 A CN104173495 A CN 104173495A
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Abstract
The invention discloses a Jiangzhining granule. The traditional Chinese medicine is prepared from the following raw materials in parts by weight: 25 to 27.5 parts of hawthorn, 1 to 1.25 parts of radix polygonum multiflorum preparata, 1 to 1.25 parts of semen cassiae and 3.25 to 3.75 parts of lotus leaves. The prepared Jiangzhining granule has functions of expanding coronary vessels, increasing coronary flow, reducing cholesterol absorption, accelerating cholesterol excretion, inhibiting the rising of serum cholesterol and the formation of atherosclerotic plaques, reducing blood fat and cholesterol and the like.
Description
Technical field
The present invention relates to Chinese drug preparation technique field.More specifically, relate to a kind of JIANGZHINING KELI and preparation method thereof.
Background technology
Cardiovascular disease is one of disease that harm humans healthy (particularly person in middle and old age) is the most common, the most serious, and dyslipidemia is the important hazard factor of atherosclerosis, coronary heart disease and other cardiovascular and cerebrovascular disease.In recent years, hyperlipidemia becomes a kind of common disease in current social development, and along with the raising of people's living standard and the change of lifestyle, the sickness rate of hyperlipidemia is also progressively rising.In the middle of adult in the whole nation more than 30 years old, the sickness rate of hyperlipidemia is in 10%-20% left and right, and hyperlipemia number is up to 9,000 ten thousand.
At present, the hypolipidemic species on market is a lot, mainly with Western medicine, is main, and in general, lipid-regulation medicine needs long-term taking, and the time, even needing of having took throughout one's life at least more than 1-2.And take pure Chinese medicinal preparation, not containing harmful chemical analysis, more not containing hormone, side effect is little, is conducive to the physical and mental health of hyperlipemia.Because this product is nontoxic drug matching, forming, is pure Chinese medicinal preparation, can not injure Liver and kidney, to human body without any side effect.And Western medicine is as all very strong in the toxicity of statins, after taking, not only can injures Liver and kidney, and cause myalgia, dyspepsia, erythra etc.
On market, the medicine of Reducing Blood Lipid by Chinese medicine is main mainly with tablet, but long in gastrointestinal disintegration time after oral, and general 15-20 minute, easily produces damage to gastric mucosa, for the more difficult hypopharynx of difficult patient of swallowing.And granulation agent is convenient to take, and the quick solution absorption of energy after oral, mouthfeel is good, is applicable to old man and child and uses.
Summary of the invention
First technical problem that the present invention will solve is to provide a kind of JIANGZHINING KELI, and this particulate species, like decoction, can be given rapidly absorption of human body, and to blood fat reducing, vessel softening, strengthens coronary flow circulation, and arrhythmia and hyperlipidemia have good therapeutic effect.
Second technical problem that the present invention will solve is to provide the preparation method of above-mentioned JIANGZHINING KELI.
For solving above-mentioned first technical problem, the present invention adopts following technical proposals:
Fructus Crataegi (enucleation) 20-25 part, Radix Polygoni Multiflori Preparata 1-1.25 part, Semen Cassiae 1-1.25 part, Folium Nelumbinis 3.25-3.75 part, Fructus Crataegi, Semen Cassiae are added to 4 times of amount pure water and decoct secondary, each 2 hours, merge decoction liquor, filter medicinal residues, filtrate is evaporated to the clear paste that relative density is 1.26-1.32 (50 ℃); All the other Folium Nelumbinis, Radix Polygoni Multiflori Preparata are measured Diluted Alcohol reflux, extract, three times with 2 times, and 3 hours for the first time, 2 hours for the second time, 1 hour for the third time, merge extractive liquid,, reclaims ethanol, and being evaporated to relative density is the clear paste of 1.2-1.26 (50 ℃), merge with above-mentioned thick paste, appropriate with sucrose, mix granulation, dry, obtain; Or it is appropriate to add dextrin, mix, granulation, dry, obtain (without sucrose).
The contained middle Fructus Crataegi of JIANGZHINING KELI is containing Crataegolic acid, Fructus Crataegi flavone.Energy dilating coronary blood vessel, increases coronary flow; The permeability that increases heart blood capillary and cardiac muscle fiber, increases myocardium nutrient flow amount; Radix Polygoni Multiflori contains chrysophanic acid, emodin, and the anthraquinones such as chrysophanol, aloe-emodin can promote intestinal peristalsis promoting, reduces cholesterol absorption, and increased excretions of cholesterol excretion reduces blood fat, antiatherogenic effect thereby play; Semen Cassiae mainly contains phytosterol and anthraquinones, has the effect that serum cholesterol raises and atheromatous plaque forms that suppresses; Folium Nelumbinis, containing nuciferine, has spasmolysis to smooth muscle.
Yellowish-brown of the present invention is to tan granule; Sour in the mouth, sweet or sour in the mouth, micro-hardship (without sucrose).To blood fat reducing, vessel softening.Be used for strengthening coronary flow circulation, arrhythmia and hyperlipidemia all have obvious curative effects.This type of form of Chinese drug, like decoction feature, can be absorbed by the body rapidly, effective fast.
In the prescription of JIANGZHINING KELI, Chinese crude drug is standard medical material of including of < < Chinese Pharmacopoeia > > (version in 2010), medication refine, with low cost, preparation technology's science.
JIANGZHINING KELI is through animal acute toxicity experiment, get 20 of mices, body weight 18-20g, with Cmax (300%), maximum volume (0.4ml/10g) once gavages, and gives mouse gavaging after 3 times continuous 2 weeks in 24 hours, and result mice is without death, show that this granule is substantially nontoxic, use safety.
Beneficial effect of the present invention is as follows:
The JIANGZHINING KELI that the present invention makes has dilating coronary blood vessel, increases coronary flow, reduces cholesterol absorption, and increased excretions of cholesterol excretion suppresses serum cholesterol rising and atheromatous plaque and forms, the effects such as blood fat reducing and cholesterol.
The specific embodiment
In order to be illustrated more clearly in the present invention, below in conjunction with preferred embodiment, describe.It will be appreciated by those skilled in the art that specifically described content is illustrative and nonrestrictive below, should not limit the scope of the invention with this.
Embodiment 1
Take Fructus Crataegi (enucleation) 500g, Radix Polygoni Multiflori Preparata 25g, Semen Cassiae 25g, Folium Nelumbinis 75g, decocts with water secondary by Fructus Crataegi, Semen Cassiae, and each 2 hours, collecting decoction, filtered, and filtrate is concentrated into the clear paste that relative density is 1.30 (50 ℃); All the other Folium Nelumbinis, Radix Polygoni Multiflori Preparata Diluted Alcohol reflux, extract, three times, 3 hours for the first time, 2 hours for the second time, 1 hour for the third time, merge extractive liquid,, reclaimed ethanol, being concentrated into relative density is the clear paste of 1.22 (50 ℃), merge with above-mentioned thick paste, with sucrose 900g, mix, make 1000g amount, granulation, dry, obtain.
Usage and dosage: oral.A 10g (1 bag), 3 times on the one.
Embodiment 2
Take Fructus Crataegi (enucleation) 500g, Radix Polygoni Multiflori Preparata 25g, Semen Cassiae 25g, Folium Nelumbinis 75g, decocts with water secondary by Fructus Crataegi, Semen Cassiae, and each 2 hours, collecting decoction, filtered, and filtrate is concentrated into the clear paste that relative density is 1.30 (50 ℃); All the other Folium Nelumbinis, Radix Polygoni Multiflori Preparata Diluted Alcohol reflux, extract, three times, 3 hours for the first time, 2 hours for the second time, 1 hour for the third time, merge extractive liquid,, reclaimed ethanol, being concentrated into relative density is the clear paste of 1.22 (50 ℃), merge with above-mentioned thick paste, add dextrin 310g, mix, make 400g amount, granulation, dry, obtain (without sucrose).
Usage and dosage: oral.A 10g (1 bag), 3 times on the one.
Effect:
Get the JIANGZHINING KELI that makes by embodiment 1 method for clinical treatment.
100 routine hyperlipemias are divided into 2 groups at random, treatment group 50 examples, male 40 examples, female's 10 examples; 35~70 years old age; Course of disease April~9 year.Matched group 50 examples, male 35 examples, female's 15 examples; 35 years old~70 years old age; The course of disease 4 months~8 years.Diagnostic criteria: reference literature standard.
Treatment group: give JIANGZHINING KELI, usage and dosage: boiled water is taken after mixing it with water, three times on the one, one time 1 bag, within 30 days, be a course for the treatment of.Matched group: give zhibituo (every 0.35g, Chengdu buchu pharmaceutical Co. Ltd), each 3, every day 3 times is oral, 20 days is a course for the treatment of, adds up after two months curative effect.
By table 1, can find out two groups of Blood Lipid before and after treatment, reference literature standard rating curative effect.Matched group 50 examples, effective 34 examples, effective 10 examples, invalid 6 examples, total effective rate 88%; Treatment group 50 examples, effective 36 examples, effective 12 examples, invalid 2 examples, total effective rate 96%, treatment group curative effect is better than matched group.
Blood Lipid (x ± s, mmol/L) before and after table 1 liang group treatment
T check; Before and after group internal therapy, compare P<0.05, P<0.01; Between group, after treatment, compare P<0.05.
Obviously; the above embodiment of the present invention is only for example of the present invention is clearly described; and be not the restriction to embodiments of the present invention; for those of ordinary skill in the field; can also make other changes in different forms on the basis of the above description; here cannot give all embodiments exhaustive, every still row in protection scope of the present invention of apparent variation that technical scheme of the present invention extends out or change that belong to.
Claims (7)
1. a JIANGZHINING KELI, is characterized in that, the raw material of following weight portion is prepared from: 25-27.5 part Fructus Crataegi, 1-1.25 part Radix Polygoni Multiflori Preparata, 1-1.25 part Semen Cassiae, 3.25-3.75 part Folium Nelumbinis.
2. the preparation method of JIANGZHINING KELI as claimed in claim 1, comprises the steps:
1), by Fructus Crataegi, Semen Cassiae decocts with water;
2) by step 1) the whole decocting liquids that obtain filter, then filtrate is concentrated, obtain clear paste A;
3) by Folium Nelumbinis and Radix Polygoni Multiflori Preparata alcohol reflux, obtain extracting solution;
4) recycling step 3) ethanol in the extracting solution that makes, concentrated residue extracting solution, obtains clear paste B;
5) clear paste A and clear paste B are merged, with sucrose or dextrin, be mixed, granulation, is drying to obtain JIANGZHINING KELI.
3. method according to claim 2, is characterized in that: step 1) described Fructus Crataegi is enucleation Fructus Crataegi, described in add water amount be Fructus Crataegi and Semen Cassiae gross mass 4 times, the number of times of described decoction is that the decocting liquid that twice, twice decoction obtains merges.
4. method according to claim 2, is characterized in that: step 2) described concentrated condition is concentrating under reduced pressure.
5. method according to claim 2, is characterized in that: step 2) density of the concentrated clear paste obtaining is 1.26-1.32.
6. method according to claim 2, is characterized in that: step 4) described concentrated condition is concentrating under reduced pressure.
7. method according to claim 2, is characterized in that: step 4) density of the concentrated clear paste obtaining is 1.20-1.26.
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104983836A (en) * | 2015-06-12 | 2015-10-21 | 天津中医药大学 | Method for extracting active components from compound blood lipid ning bulk drugs |
CN106994143A (en) * | 2016-01-26 | 2017-08-01 | 上海华源制药安徽广生药业有限公司 | A kind of sugar-free JIANGZHINING KELI and preparation method thereof |
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CN1682936A (en) * | 2005-02-25 | 2005-10-19 | 石家庄四药有限公司 | Medicinal composition for treating hyperlipemia and its preparing method |
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104983836A (en) * | 2015-06-12 | 2015-10-21 | 天津中医药大学 | Method for extracting active components from compound blood lipid ning bulk drugs |
CN104983836B (en) * | 2015-06-12 | 2018-03-30 | 天津中医药大学 | A kind of method that active component is extracted in the bulk drug peaceful from compound blood fat |
CN106994143A (en) * | 2016-01-26 | 2017-08-01 | 上海华源制药安徽广生药业有限公司 | A kind of sugar-free JIANGZHINING KELI and preparation method thereof |
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