CN111714553A - A Chinese medicinal composition for treating new coronary pneumonia and/or influenza, and its preparation method - Google Patents
A Chinese medicinal composition for treating new coronary pneumonia and/or influenza, and its preparation method Download PDFInfo
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- CN111714553A CN111714553A CN202010581336.7A CN202010581336A CN111714553A CN 111714553 A CN111714553 A CN 111714553A CN 202010581336 A CN202010581336 A CN 202010581336A CN 111714553 A CN111714553 A CN 111714553A
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Abstract
The invention provides a traditional Chinese medicine composition for treating neocoronary pneumonia and/or influenza and a preparation method thereof, belonging to the technical field of traditional Chinese medicines. The invention provides a traditional Chinese medicine composition for treating neocoronary pneumonia and/or influenza, which comprises the following components in parts by weight: 5-30 parts of astragalus membranaceus, 5-30 parts of radix puerariae, 5-30 parts of radix bupleuri, 5-30 parts of honeysuckle, 5-30 parts of fructus forsythiae, 5-30 parts of agastache rugosus, 2-20 parts of Dahuang processed with wine, 5-30 parts of platycodon grandiflorum, 3-30 parts of raw epimedium, 5-30 parts of fried rhizoma atractylodis, 5-30 parts of radish seed, 3-20 parts of dried orange peel, 5-30 parts of white paeony root, 5-30 parts of poria cocos, 3-20 parts of mint and 2-20 parts of liquorice. The Chinese medicinal composition has the effects of strengthening body resistance and invigorating spleen, regulating qi-flowing and regulating the middle warmer, clearing away damp-heat, permeating exterior lightly, and strengthening body constitution, and can be used for preventing and treating new crown pneumonia and influenza.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating new coronary pneumonia and/or influenza and a preparation method thereof.
Background
Symptoms of new coronary pneumonia and influenza have some similar symptoms, such as fever, cough, sputum and the like. The influenza is caused by infection of influenza virus, symptoms such as nasal obstruction and rhinorrhea easily occur, low-moderate fever of about three to five days also occurs, and systemic symptoms such as muscle ache and weakness are easily caused. Patients with new coronary pneumonia are also infected with new coronavirus (COVID-19), and symptoms are persistent fever and repeated even with fever reduction. Meanwhile, patients with new coronary pneumonia are easy to have severe dry cough and even respiratory symptoms such as dyspnea. Some patients may also have symptoms such as vomiting and diarrhea, but a less ill patient may have rhinorrhea or nasal obstruction.
At present, no specific medicine for treating the new coronary pneumonia exists at home and abroad, and the clinical treatment is mainly used, and the improvement of the immunity of the organism is assisted to resist the new coronary pneumonia. Meanwhile, aiming at the treatment of influenza, the immunity of the organism is improved, and the antiviral western medicine is adopted for treatment. At present, no Chinese patent medicine which has curative effects on influenza and new coronary pneumonia at the same time is reported.
Disclosure of Invention
In view of the above, the present invention aims to provide a traditional Chinese medicine composition for treating new coronary pneumonia and/or influenza and a preparation method thereof, which can effectively prevent and treat new coronary pneumonia and/or influenza.
The invention provides a traditional Chinese medicine composition for treating neocoronary pneumonia and/or influenza, which comprises the following components in parts by weight: 5-30 parts of astragalus membranaceus, 5-30 parts of radix puerariae, 5-30 parts of radix bupleuri, 5-30 parts of honeysuckle, 5-30 parts of fructus forsythiae, 5-30 parts of wrinkled gianthyssop herb, 2-20 parts of Dahuang processed with wine, 5-30 parts of platycodon grandiflorum, 3-30 parts of raw epimedium, 5-30 parts of fried rhizoma atractylodis, 5-30 parts of radish seed, 3-20 parts of dried orange peel, 5-30 parts of white paeony root, 5-30 parts of poria cocos, 3-20 parts of mint and 2-20 parts of liquorice.
Preferably, the composition comprises the following components in parts by weight: 10-25 parts of astragalus membranaceus, 10-25 parts of radix puerariae, 10-25 parts of bupleurum root, 10-25 parts of honeysuckle, 10-25 parts of fructus forsythiae, 10-25 parts of agastache rugosus, 6-16 parts of rhubarb processed with wine, 10-25 parts of platycodon grandiflorum, 10-24 parts of raw epimedium, 10-25 parts of fried rhizoma atractylodis, 10-25 parts of flatfish radish seed, 7-16 parts of dried orange peel, 10-25 parts of white paeony root, 10-25 parts of poria cocos, 10-17 parts of mint and 8-17 parts of liquorice.
Preferably, the composition comprises the following components in parts by weight: 18 parts of astragalus mongholicus, 15 parts of radix puerariae, 15 parts of radix bupleuri, 18 parts of honeysuckle, 15 parts of fructus forsythiae, 20 parts of wrinkled gianthyssop herb, 12 parts of yellow rhubarb, 18 parts of platycodon grandiflorum, 17 parts of raw epimedium herb, 18 parts of fried rhizoma atractylodis, 18 parts of fry radish seed, 12 parts of dried orange peel, 17 parts of white paeony root, 18 parts of poria cocos, 13 parts of mint and 13 parts of liquorice.
The invention provides a preparation method of the traditional Chinese medicine composition, which comprises the following steps:
1) distilling herba Agastaches and herba Menthae with steam to extract volatile components to obtain herba Agastaches and herba Menthae distillate;
2) radix astragali, radix Puerariae, bupleuri radix, flos Lonicerae, fructus forsythiae, herba et Gemma Agrimoniae processed with wine, radix Platycodi, herba Epimedii, rhizoma Atractylodis parched, semen Raphani, pericarpium Citri Tangerinae, radix Paeoniae alba, Poria and Glycyrrhrizae radix by extracting medicinal active ingredients with water to obtain water extractive solution;
3) mixing the agastache rugosus and mint distillate with the water extraction liquid medicine, and concentrating to obtain a traditional Chinese medicine composition;
there is no chronological restriction between step 1) and step 2).
Preferably, the volume ratio of the total mass of the agastache rugosa and the mint in the step 1) to the water used for steam is 1 g: 4-8 mL; the distillation and extraction time is 4-6 h.
Preferably, the number of times of the extraction in the step 2) is 2;
during extraction at the 1 st time, 1g of total mass of astragalus, radix puerariae, radix bupleuri, honeysuckle, fructus forsythiae, rhubarb processed with wine, platycodon grandiflorum, raw epimedium, stir-fried rhizoma atractylodis, radish seed, dried orange peel, radix paeoniae alba, poria cocos and liquorice in a volume ratio to water: 8-12 mL; the time for the 1 st extraction is 1-2 h;
in the 2 nd extraction, mixing the residue obtained in the 1 st extraction with water; the mass ratio of the medicine dregs to the volume of water is 1 g: 6-8 mL; the time for the 2 nd extraction is 1-1.5 h;
the temperature of the two extractions is 80-100 ℃.
The volume concentration of the ethanol mixed liquid medicine in the step 3) is 55-75%.
Preferably, the concentration further comprises adding ethanol into the obtained concentrated liquid medicine until the volume concentration reaches 50-80%, purifying, collecting the supernatant, and removing the ethanol to obtain the traditional Chinese medicine composition.
Preferably, when the dosage form of the traditional Chinese medicine composition is a solid preparation, the supernatant fluid without ethanol is concentrated, dried and crushed to obtain medicinal powder;
when the solid preparation is dispersant or granule, the medicinal powder is directly subpackaged to obtain;
when the solid preparation is capsule, filling the medicinal powder into hollow hard capsule, and making into capsule;
when the solid preparation is tablet, the medicinal powder is mixed with tablet adjuvants, and tabletted to make tablet.
When the solid preparation is pill, mixing the medicinal powder, pill adjuvants and binder, and making into watered pill, honeyed pill, watered honeyed pill, concentrated pill, paste pill or wax pill;
the weight of the medicinal powder is calculated by 100%, the adding weight of pill auxiliary materials is 20-40% and the adding weight of the adhesive is 3-10%.
Preferably, when the dosage form of the traditional Chinese medicine composition is a water aqua, the supernatant liquid after ethanol removal is concentrated and then directly subpackaged into decoction, or the supernatant liquid is concentrated to obtain a concentrated solution which is blended to obtain the oral liquid;
the mass ratio of the concentrated solution to the blending auxiliary materials is (1-4): (6-9); the blending auxiliary materials comprise sucrose and/or honey;
the concentration degree is that the relative density of the supernatant is 1.1-1.30 when the supernatant is concentrated to 50 ℃.
Preferably, when the dosage form of the Chinese medicinal composition is dripping pill, heating, melting and mixing the supernatant without ethanol and the dripping pill matrix, dripping into immiscible condensate, and contracting and condensing to obtain dripping pill preparation.
The invention provides a traditional Chinese medicine composition for treating new coronary pneumonia and/or influenza, which is prepared by combining 16 traditional Chinese medicine components and has the effects of strengthening body resistance and strengthening spleen, regulating vital energy and regulating middle warmer, clearing damp-heat, permeating exterior lightly and strengthening body. The rhizoma atractylodis is used for strengthening body resistance, tonifying qi and strengthening exterior to strengthen the disease resistance of human body constitution, and is matched with adjuvant drugs of white paeony root, blewing radish seed, dried orange peel and liquorice to strengthen the spleen and stomach in a synergistic manner and strengthen and stimulate the digestion function. Honeysuckle, Dahuang made with wine, kudzu vine root and bupleurum root in ministerial drugs play roles of clearing heat, detoxifying and broad-spectrum antagonistic virus germs. The honeysuckle has strong bacteriostatic action on various viruses, bacilli, vibrio cholerae, staphylococcus and streptococcus. The epimedium contains icariine, volatile oil, ceryl alcohol, phytosterol, tannin, vitamin E and other components, can excite sexual function, also can lower blood pressure (causing peripheral vasodilatation), lower blood sugar, promote urination, relieve cough, eliminate phlegm, increase blood flow of heart and cerebral vessels, promote hematopoiesis, improve immunity and bone metabolism, has broad-spectrum antiviral and anti-aging effects, and can effectively kill cancer cells. Meanwhile, the bupleurum root is matched with the mint to relieve depression and raise yang, and dispel wind and reduce fever. The mint is cool and refreshing, and can clear away heart-fire and relieve fever. Aiming at the novel pneumonia, the pathogenic factors are mostly generated from the interior, and some patients are caused by the pathogenic factors, so that the clearance is important. The kudzu vine root is mainly used for relieving muscles and relieving exterior syndrome, reducing fire and expelling toxin, is matched with the bupleurum root to relieve the fever of the shaoyang exterior half, relieve depression and ascend clear, and has stronger efficacy of relieving muscles and relieving fever and relieving exterior syndrome by combining the two medicines. Based on the current mastered condition, the novel pneumonia attacks the heart, symptoms such as myocarditis and the like easily occur, and the kudzuvine root has good influence on the metabolism of the myocardium, so that the work efficiency of the myocardium is improved, and the kudzuvine root has a certain effect on adjusting the oxygen supply balance of the myocardium. In addition, Huoxiang, cang Zhu, Fu Zi, and jin Yin Hua are used to clear interior heat, the lung and large intestine are exterior and interior, and Da Huang is used to expel lung toxin from the intestines. Based on tidal fever and damp-heat in less water, crime new pneumonia epidemic is diffuse in damp toxin, and the idea of eliminating evil, clearing heat, removing dampness and dredging membrane is adopted to prevent and treat new coronary pneumonia infection and influenza. The traditional Chinese medicine composition provided by the invention can be taken by different drug-receiving people, and after cold patients take the medicine for 7 days (doses) continuously, the normal state is basically recovered, and the body does not have discomfort; after the medicine is taken for 2 weeks to 1 month, the patients with cold and new crown infection are not existed. The result shows that the traditional Chinese medicine composition provided by the invention can be effectively used for preventing and treating the new coronary pneumonia or the influenza.
Drawings
FIG. 1 is a pie chart of the dosage of a Chinese medicinal composition administered;
FIG. 2 is a pie chart of the proportion of males and females in a population of subjects;
FIG. 3 shows the administration of precursor substances to a population of subjects.
Detailed Description
The invention provides a traditional Chinese medicine composition for treating neocoronary pneumonia and/or influenza, which comprises the following components in parts by weight: 5-30 parts of astragalus membranaceus, 5-30 parts of radix puerariae, 5-30 parts of radix bupleuri, 5-30 parts of honeysuckle, 5-30 parts of fructus forsythiae, 5-30 parts of wrinkled gianthyssop herb, 2-20 parts of Dahuang processed with wine, 5-30 parts of platycodon grandiflorum, 3-30 parts of raw epimedium, 5-30 parts of fried rhizoma atractylodis, 5-30 parts of radish seed, 3-20 parts of dried orange peel, 5-30 parts of white paeony root, 5-30 parts of poria cocos, 3-20 parts of mint and 2-20 parts of liquorice.
The traditional Chinese medicine composition comprises astragalus membranaceus. The astragalus mongholicus is preferably 10-25 parts by weight, and more preferably 18 parts by weight. The radix astragali has effects of invigorating qi and strengthening body resistance.
The traditional Chinese medicine composition comprises kudzu root. The kudzuvine root is preferably 10-25 parts by weight, and more preferably 15 parts by weight. The kudzu vine root has the functions of expelling pathogenic factors from muscles and skin, reducing pathogenic fire and expelling toxin, is matched with the bupleurum root to release the heat of the shaoyang exterior half, relieve depression and ascend clear, and has stronger efficacy of expelling pathogenic factors from muscles and skin and expelling toxin. Based on the current mastered condition, the novel pneumonia attacks the heart, myocarditis and other symptoms are easy to appear, and the kudzuvine root has good influence on the metabolism of the cardiac muscle, so that the work efficiency of the cardiac muscle is improved, and especially, the kudzuvine root has a certain effect on adjusting the oxygen supply balance of the cardiac muscle.
The traditional Chinese medicine composition comprises radix bupleuri. The bupleurum is preferably 10 to 25 parts by weight, and more preferably 15 parts by weight. The radix bupleuri is matched with the mint to play the effects of resolving depression, invigorating yang, dispelling wind and reducing fever.
The traditional Chinese medicine composition comprises honeysuckle. The honeysuckle is preferably 10-25 parts by weight, and more preferably 18 parts by weight. The honeysuckle has strong bacteriostatic action on various viruses, bacilli, vibrio cholerae, staphylococcus and streptococcus.
The traditional Chinese medicine composition comprises fructus forsythiae. The forsythia is preferably 10 to 25 parts by weight, and more preferably 15 parts by weight. The fructus forsythiae has the effects of clearing away heat and toxic materials.
The traditional Chinese medicine composition comprises agastache rugosus. The agastache rugosa is preferably 10-25 parts by weight, and more preferably 20 parts by weight. The combination of Huoxiang and jin Yin Hua can clear internal heat, and the exterior and interior of the lung and large intestine are mutually, so that the heat-evil and lung toxicity can be discharged from the intestinal tract by using rhubarb. Based on tidal fever, damp-heat and diffuse toxicity of crime novel pneumonia epidemic, the thought of eliminating pathogenic factors, clearing heat, removing dampness, dredging membrane is adopted to make the medicine become even.
The traditional Chinese medicine composition comprises yellow dock root. Preferably, the yellow wine prepared rhubarb is 6-16 parts by weight, and more preferably 12 parts by weight. The prepared rhubarb horsetails exert the effects of clearing heat and detoxifying, and antagonizing virus and germs in a broad spectrum.
The traditional Chinese medicine composition comprises platycodon grandiflorum. The platycodon grandiflorum is preferably 6-16 parts by weight, and more preferably 18 parts by weight. The radix Platycodi has effects of dispersing lung qi and relieving sore throat.
The traditional Chinese medicine composition comprises raw epimedium herb. The raw epimedium is preferably 10-24 parts by weight, and more preferably 17 parts by weight. The raw epimedium contains icariine, volatile oil, ceryl alcohol, phytosterol, tannin, vitamin E and other components, can excite sexual function, also has the functions of reducing blood pressure (causing peripheral blood vessel relaxation), reducing blood sugar, promoting urination, relieving cough, eliminating phlegm, increasing blood flow of heart and cerebral vessels, promoting hematopoietic function, improving immunologic function and bone metabolism, has broad-spectrum antiviral and anti-aging effects and can effectively kill cancer cells.
The traditional Chinese medicine composition comprises Chinese atractylodes cake. The amount of the bran-fried rhizoma atractylodis is preferably 10-25 parts by weight, and more preferably 18 parts by weight. The fried rhizoma atractylodis has the effects of strengthening body resistance, benefiting qi and strengthening exterior to strengthen the disease resistance of human physique, and has the effects of strengthening spleen and stomach and enhancing and reviving digestion functions in cooperation with adjuvant medicines of white paeony root, semen raphani, dried orange peel and liquorice. At the same time, cang Zhu and jin Yin Hua are used to clear internal heat, so that the lung and large intestine are exterior to interior, and Da Huang is used to expel lung-toxicity from the intestine. Based on the fact that the tidal heat and damp-heat are lower in the area hong and Australia and the novel pneumonia epidemic crime is pervasive in damp-toxin, the thought of eliminating evil, clearing heat, removing dampness and dredging membrane is adopted to make the pneumonia become even.
The traditional Chinese medicine composition comprises semen raphani. The weight part of the Mandarin radish seed is preferably 10-25 parts, and more preferably 18 parts. The yang-qi deficiency is caused by the fact that the yang-qi is added with the yang-qi, the. Based on tidal fever and damp-heat in less tidal waters and diffuse toxicity of crime novel pneumonia epidemic, the thought of eliminating pathogenic factors, clearing heat, removing dampness and dredging membrane is adopted to make the pneumonia become even.
The traditional Chinese medicine composition comprises dried orange peel. The dried orange peel is preferably 7-16 parts by weight, and more preferably 12 parts by weight. The dried orange peel, the white paeony root, the blewing radish seed and the liquorice are used as adjuvant medicines to synergistically strengthen the spleen and the stomach and enhance and stimulate the digestion function.
The traditional Chinese medicine composition comprises white paeony root. The white peony root is preferably 10-25 parts by weight, and more preferably 17 parts by weight. The white paeony root, the dried orange peel, the blewing radish seed and the liquorice are used as adjuvant medicines to synergistically strengthen the spleen and the stomach and enhance and stimulate the digestion function.
The traditional Chinese medicine composition comprises poria cocos. The poria cocos is preferably 10-25 parts by weight, and more preferably 18 parts by weight. The Poria has effects of inducing diuresis with bland drugs.
The traditional Chinese medicine composition comprises mint. The mint is preferably 10-17 parts by weight, and more preferably 13 parts by weight. In the present invention, the mint is used for refreshing and cooling the heart and relieving fever. Bupleurum root, radix bupleuri is used in combination with Boerhavia diffusa to relieve depression and raise yang, and to dispel wind and reduce fever. Aiming at the novel pneumonia, the pathogenic factors are mostly latent and the latent pathogenic factors are caused by the new affection of exogenous pathogenic factors, so that the dredging and clearing are important.
The traditional Chinese medicine composition comprises liquorice. The liquorice is preferably 8-17 parts by weight, and more preferably 13 parts by weight. The liquorice, the white paeony root, the dried tangerine peel and the blewing radish seed are used as adjuvant drugs to synergistically strengthen the spleen and the stomach and enhance and stimulate the digestion function.
The source of the 16 Chinese medicaments is not particularly limited in the invention, and the source of the Chinese medicaments known in the field can be adopted.
The invention provides a preparation method of the traditional Chinese medicine composition, which comprises the following steps:
1) distilling herba Agastaches and herba Menthae with steam to extract volatile components to obtain herba Agastaches and herba Menthae distillate;
2) radix astragali, radix Puerariae, bupleuri radix, flos Lonicerae, fructus forsythiae, herba et Gemma Agrimoniae processed with wine, radix Platycodi, herba Epimedii, rhizoma Atractylodis parched, semen Raphani, pericarpium Citri Tangerinae, radix Paeoniae alba, Poria and Glycyrrhrizae radix by extracting medicinal active ingredients with water to obtain water extractive solution;
3) mixing the agastache rugosus and mint distillate with the water extraction liquid medicine, and concentrating to obtain a traditional Chinese medicine composition;
there is no chronological restriction between step 1) and step 2).
The invention distills agastache rugosus and mint by steam to extract volatile components of the components, thus obtaining agastache rugosus and mint distillate.
In the present invention, the ratio of the total mass of the agastache rugosa and mint to the volume of water for steam is preferably 1 g: 4-8 mL, more preferably 1 g: 5-7 mL, most preferably 1 g: 6 mL. The time for distillation and extraction is preferably 4-6 h, and more preferably 5 h. The distillation extraction is beneficial to extracting volatile active substances in the agastache rugosa and the mint.
According to the invention, water is used for extracting medicinal active ingredients from astragalus membranaceus, radix puerariae, radix bupleuri, honeysuckle, fructus forsythiae, rhubarb processed with wine, platycodon grandiflorum, epimedium, fried rhizoma atractylodis, radish seed, dried orange peel, radix paeoniae alba, poria cocos and liquorice to obtain a water extraction liquid medicine.
In the present invention, the number of times of the extraction is preferably 2; in the extraction of the 1 st time, the volume ratio of the total mass of the astragalus, the root of kudzu vine, the radix bupleuri, the honeysuckle, the fructus forsythiae, the rhubarb processed with wine, the platycodon grandiflorum, the raw epimedium, the bran-fried rhizoma atractylodis, the radish seed, the dried orange peel, the white paeony root, the poria cocos and the liquorice to the water is preferably 1 g: 8-12 mL, more preferably 1 g: 10 mL; the time for the 1 st extraction is preferably 1-2 h, and more preferably 1.5 h; in the 2 nd extraction, mixing the residue obtained in the 1 st extraction with water; the mass of the dregs of a decoction to the volume ratio of water is preferably 1 g: 6-8 mL, more preferably 1 g: 7 mL; the time for the 2 nd extraction is preferably 1-1.5 h, and more preferably 1.2 h. The temperature of the two extractions is preferably 80-100 ℃, and more preferably 85-95 ℃. After extraction, solid-liquid separation is carried out, and the two extracting solutions are mixed to obtain water extracting liquid medicine. The method of the solid-liquid separation in the present invention is not particularly limited, and a solid-liquid separation method known in the art, such as filtration, may be employed.
After the ageratum and mint distillate and the water extraction liquid medicine are obtained, the ageratum and mint distillate and the water extraction liquid medicine are mixed and concentrated to obtain the traditional Chinese medicine composition.
In the present invention, the concentration is preferably performed so that the volume ratio of the crude drug to the drug solution is 1: 1. And drying is also included after the concentration. The drying method is not particularly limited in the present invention, and spray drying, microwave drying and reduced pressure drying, which are well known in the art, may be used.
In the invention, the concentration preferably includes purification, and the purification method comprises the steps of adding ethanol into the obtained concentrated liquid medicine until the volume concentration reaches 50-80%, purifying, collecting supernatant, and removing ethanol to obtain the traditional Chinese medicine composition. In the present invention, the volume concentration of the ethanol mixed chemical solution is preferably 55% to 75%, more preferably 60% to 70%, and most preferably 65%. The purification method is static standing, and the time of the static standing is preferably 2-3 h. The method for removing ethanol preferably adopts a method of reduced pressure distillation to remove ethanol.
In the invention, the preparation method is different according to different preparation forms of the prepared traditional Chinese medicine composition:
when the dosage form of the traditional Chinese medicine composition is a water aqua, the supernatant liquid after ethanol removal is preferably concentrated and then directly subpackaged into decoction, or the supernatant liquid is concentrated to obtain concentrated solution, and the concentrated solution is blended to obtain the oral liquid. The concentration degree is that the supernatant is concentrated to the relative density of 1.05-1.20. The mass percentage of the concentrated solution and the auxiliary materials for blending is preferably (1-4): (0.5 to 2), more preferably 1: 0.5 or 4: 1 or 3: 1; the auxiliary materials for blending preferably comprise sucrose and/or honey; the preparation process can be omitted for people with diabetes according to different people.
In the invention, when the dosage form of the traditional Chinese medicine composition is preferably a solid preparation, the supernatant fluid after ethanol removal is preferably concentrated, dried and crushed in sequence to obtain medicinal powder; the degree of concentration is preferably a concentrated paste having a relative density of 1.05 to 1.20. The drying temperature is preferably 60-80 ℃, and more preferably 60 ℃.
When the solid preparation is a dispersing agent or granules, the medicinal powder is preferably directly subpackaged.
When the solid preparation is a capsule, the medicinal powder is preferably filled in an empty hard capsule to prepare the capsule.
When the solid preparation is a tablet, the medicinal powder is preferably mixed with tablet excipients, tableted and made into tablets.
When the solid preparation is pill, preferably mixing the medicinal powder, pill adjuvants and binder, and making into watered pill, honeyed pill, watered honeyed pill, concentrated pill, paste pill or wax pill; the weight of the medicinal powder is calculated by 100%, the adding weight of the pill auxiliary materials is 20-40%, more preferably 40%, and the adding weight of the adhesive is 3-10%, more preferably 10%. The types of the pill auxiliary materials are not particularly limited, and the pill auxiliary materials well known in the field can be adopted, such as medical and edible auxiliary materials such as dextrin, maltodextrin, lactose or starch. The kind of the binder is not particularly limited, and any binder known in the art may be used, for example, water, honey, maltose, rice water, etc.
When the solid preparation is soft capsule, the medicinal powder is dissolved in the adjuvant of the soft capsule, and then sealed in spherical or olive-shaped soft capsule by pressing (or dripping) to obtain soft capsule.
When the dosage form of the traditional Chinese medicine composition is a dripping pill, heating, melting and uniformly mixing the supernatant without ethanol and a dripping pill substrate, dripping into immiscible condensate, and performing contraction and condensation to prepare a dripping pill preparation.
The invention has no special limitation on the types of the auxiliary materials used in different formulations, and the auxiliary materials well known in the field can be adopted. The present invention is not particularly limited in the preparation process of the various dosage forms, and the preparation method well known in the art may be used. The traditional Chinese medicine composition is orally taken. The dosage of the oral preparation is 1 dose a day, and 2-3 times a day. It is recommended to be taken half an hour after meals.
The following examples are provided to describe the Chinese medicinal composition for treating new coronary pneumonia and/or influenza and the preparation method thereof in detail, but they should not be construed as limiting the scope of the present invention.
Example 1
Accurately weighing the following traditional Chinese medicine raw materials by mass: 50g of astragalus membranaceus (raw), 200g of kudzuvine root, 70g of radix bupleuri, 300g of honeysuckle, 200g of fructus forsythiae, 50g of wrinkled gianthyssop herb, 20g of rhubarb (processed with wine), 300g of platycodon grandiflorum, 30g of epimedium (raw), 30g of rhizoma atractylodis (fried), 50g of radish seed, 20g of dried orange peel, 50g of white paeony root, 300g of poria cocos, 30g of mint and 200g of liquorice.
The preparation method of the traditional Chinese medicine composition oral liquid comprises the following steps:
1) mixing herba Menthae and herba Agastaches, extracting under water vapor for 4 hr, and collecting mixed distillate;
2) mixing radix astragali, radix Puerariae, bupleuri radix, flos Lonicerae, fructus forsythiae, herba et Gemma Agrimoniae processed with wine, radix Platycodi, herba Epimedii, rhizoma Atractylodis parched, semen Raphani, pericarpium Citri Tangerinae, radix Paeoniae alba, Poria and Glycyrrhrizae radix, adding 10 times of water, decocting for 1.5h, separating extractive solution, extracting the rest residues with 8 times of water for 1h, and mixing the extractive solution with the previous extractive solution to obtain extractive solution;
3) mixing the mixed distillate with the extractive solution, concentrating until the volume ratio of the crude drug to the extractive solution is 1:1, adding ethanol to make the final concentration of ethanol reach 50%, mixing, standing for 2 hr, collecting supernatant, removing ethanol under reduced pressure, and collecting the extractive solution;
4) according to the mass ratio of the liquid medicine to the auxiliary materials (honey and cane sugar) of 7: 1 to obtain the oral liquid.
Example 2
Accurately weighing the following traditional Chinese medicine raw materials by mass: 250g of astragalus mongholicus, 100g of radix puerariae, 250g of radix bupleuri, 100g of honeysuckle, 250g of fructus forsythiae, 100g of wrinkled gianthyssop herb, 160g of yellow dock, 100g of platycodon grandiflorum, 240g of raw epimedium herb, 100g of fried rhizoma atractylodis, 250g of radish seed, 70g of dried orange peel, 250g of white paeony root, 100g of poria cocos, 170g of thin lotus and 80g of liquorice.
The preparation method of the Chinese medicinal composition decoction comprises the following steps:
1) mixing herba Menthae and herba Agastaches, extracting under water vapor for 6 hr, and collecting mixed distillate;
2) mixing radix astragali, radix Puerariae, bupleuri radix, flos Lonicerae, fructus forsythiae, herba et Gemma Agrimoniae processed with wine, radix Platycodi, herba Epimedii, rhizoma Atractylodis parched, semen Raphani, pericarpium Citri Tangerinae, radix Paeoniae alba, Poria and Glycyrrhrizae radix, adding 12 times of water, decocting for 2h, separating extractive solution, extracting the residue with 6 times of water for 1.5h, and mixing the extractive solution with the previous extractive solution to obtain extractive solution;
3) mixing the mixed distillate and the extractive solution, concentrating until the volume ratio of the crude drug to the extractive solution is 1:1, adding ethanol until the final concentration of ethanol reaches 70%, mixing, standing for 2 hr, collecting supernatant, removing ethanol under reduced pressure, collecting medicinal solution, and packaging to obtain Chinese medicinal decoction.
Example 3
Accurately weighing the following traditional Chinese medicine raw materials by mass: 180g of astragalus mongholicus, 150g of radix puerariae, 150g of radix bupleuri, 180g of honeysuckle, 150g of fructus forsythiae, 200g of wrinkled gianthyssop herb, 120g of yellow dock, 180g of platycodon grandiflorum, 170g of raw epimedium herb, 180g of fried rhizoma atractylodis, 180g of radish seed, 120g of dried orange peel, 170g of white paeony root, 180g of poria cocos, 130g of thin lotus and 130g of liquorice.
The preparation method of the traditional Chinese medicine composition dispersing agent comprises the following steps:
1) mixing herba Menthae and herba Agastaches, extracting under water vapor for 5 hr, and collecting mixed distillate;
2) mixing radix astragali, radix Puerariae, bupleuri radix, flos Lonicerae, fructus forsythiae, herba et Gemma Agrimoniae processed with wine, radix Platycodi, herba Epimedii, rhizoma Atractylodis parched, semen Raphani, pericarpium Citri Tangerinae, radix Paeoniae alba, Poria and Glycyrrhrizae radix, adding 8 times of water, decocting for 1h, separating extractive solution, extracting the residue with 8 times of water for 1h, and mixing the extractive solution with the previous extractive solution to obtain extractive solution;
3) mixing the mixed distillate with the extractive solution, and concentrating to relative density of 1.3(50 deg.C);
4) drying the above medicinal liquid at 50 deg.C with microwave, and pulverizing to obtain Chinese medicinal composition dispersant.
Example 4
Accurately weighing the following traditional Chinese medicine raw materials by mass: 300g of astragalus mongholicus, 300g of radix puerariae, 200g of radix bupleuri, 300g of honeysuckle, 200g of fructus forsythiae, 200g of wrinkled gianthyssop herb, 80g of rhubarb (processed with wine), 200g of platycodon grandiflorum, 160g of epimedium, 300g of rhizoma atractylodis (fried), 250g of boiled radish seed, 100g of dried orange peel, 300g of white paeony root, 300g of poria cocos, 200g of mint and 100g of liquorice, and the weight of the yellow pig.
The preparation method of the traditional Chinese medicine composition granules comprises the following steps:
1) mixing herba Menthae and herba Agastaches, extracting with water vapor for 5 hr, and collecting volatile oil distillate of herba Menthae and herba Agastaches;
2) mixing radix astragali, radix Puerariae, bupleuri radix, flos Lonicerae, fructus forsythiae, herba et Gemma Agrimoniae processed with wine, radix Platycodi, herba Epimedii, rhizoma Atractylodis parched, semen Raphani, pericarpium Citri Tangerinae, radix Paeoniae alba, Poria and Glycyrrhrizae radix, adding 10 times of water, decocting for 1.5h, separating extractive solution, extracting the rest residues with 7 times of water for 1h, and mixing the extractive solution with the previous extractive solution to obtain extractive solution;
3) purifying the extractive solution with 65% ethanol, removing ethanol from the obtained supernatant, concentrating to relative density of 1.20(50 deg.C), spray drying, adding dextrin as adjuvant, mixing, granulating, drying, sieving to obtain fine powder, dissolving the volatile oil of herba Menthae and herba Agastaches with appropriate amount of ethanol, spraying or adding into the fine powder, mixing with the above granules, sealing for 30min, and making into granule.
Example 5
300g of astragalus mongholicus, 300g of radix puerariae, 200g of radix bupleuri, 300g of honeysuckle, 200g of wrinkled gianthyssop herb, 80g of Dahuang (processed with wine), 200g of platycodon grandiflorum, 160g of epimedium herb, 300g of rhizoma atractylodis (fried), 250g of fry radish seed, 100g of old skin, 300g of white paeony root, 300g of poria cocos, 200g of mint, 200g of fructus forsythiae and 100g of liquorice. 1000g was prepared.
The preparation method of the traditional Chinese medicine composition tablet comprises the following steps:
1) mixing herba Menthae and herba Agastaches, extracting with water vapor for 5 hr, and collecting volatile oil distillate of herba Menthae and herba Agastaches;
2) mixing radix astragali, radix Puerariae, bupleuri radix, flos Lonicerae, fructus forsythiae, herba et Gemma Agrimoniae processed with wine, radix Platycodi, herba Epimedii, rhizoma Atractylodis parched, semen Raphani, pericarpium Citri Tangerinae, radix Paeoniae alba, Poria and Glycyrrhrizae radix, adding 9 times of water, decocting for 2 hr, separating extractive solution, extracting the residue with 8 times of water for 1.5 hr, and mixing the extractive solution with the previous extractive solution to obtain extractive solution;
3) purifying the extractive solution with 75% ethanol, removing ethanol from the obtained supernatant, concentrating to relative density of 1.25(60 deg.C), spray drying, adding starch as adjuvant, mixing, dissolving the volatile oil of herba Menthae and herba Agastaches with appropriate amount of ethanol, adding into the mixture, mixing, tabletting, sealing for 30min, and making into tablet.
Example 6
300g of astragalus mongholicus, 300g of radix puerariae, 180g of radix bupleuri, 300g of honeysuckle, 200g of wrinkled gianthyssop herb, 80g of Dahuang (processed by wine), 200g of platycodon grandiflorum, 160g of epimedium herb, 300g of rhizoma atractylodis (fried), 250g of fry radish seed, 100g of old skin, 300g of white paeony root, 300g of poria cocos, 200g of mint, 200g of fructus forsythiae and 100g of liquorice. 1000g was prepared.
The preparation method of the Chinese medicinal composition honeyed pill comprises the following steps:
1) mixing herba Menthae and herba Agastaches, extracting under water vapor for 6 hr, and collecting volatile oil distillate of herba Menthae and herba Agastaches;
2) mixing radix astragali, radix Puerariae, bupleuri radix, flos Lonicerae, fructus forsythiae, herba et Gemma Agrimoniae processed with wine, radix Platycodi, herba Epimedii, rhizoma Atractylodis parched, semen Raphani, pericarpium Citri Tangerinae, radix Paeoniae alba, Poria and Glycyrrhrizae radix, adding 12 times of water, decocting for 1h, separating extractive solution, extracting the residue with 6 times of water for 1h, and mixing the extractive solution with the previous extractive solution to obtain extractive solution;
3) mixing the extractive solution with volatile oil distillate of herba Menthae and herba Agastaches, purifying with 80% ethanol, removing ethanol from the supernatant under reduced pressure, concentrating the extractive solution under reduced pressure to obtain concentrated extract with relative density of 1.35, and adding refined honey (concentrated extract: 1, honey: 1 or 1: 0.9, mass ratio), mixing evenly, and preparing into honeyed pills.
Example 7
1. Start and end date of experiment: 7 days in month 2-4 days in 2020.
2. Purpose and observation index: preliminarily observing the physical and pathological reactions of different drug-receiving people of the traditional Chinese medicine composition after taking the medicine, including adverse reaction information; it is important to know whether the cold and the new coronary pneumonia are infected after taking the medicine for 1 month.
1) The dosage of the Chinese medicinal composition is shown in Table 1 and figure 1.
TABLE 1 statistical table of dosage ratios of Chinese medicinal composition for administration
| Dosage (dose) of the medicine to be taken | 2 | 3 | 5 | 7 |
| Ratio (%) | 0.40 | 85.66 | 11.95 | 1.99 |
2) Basic information data of user
A. Age range: among the 251 people population, the age was the smallest to largest: 22-73 years old; the average age was 40 years, as shown in Table 2.
TABLE 2 proportion of each age group
| Age (year of old) | 20～30 | 30～40 | 40～50 | 50～60 | More than 60 |
| Ratio (%) | 11.55 | 49.80 | 30.28 | 6.77 | 1.59 |
B. The sex ratios are shown in table 3 and figure 2.
TABLE 3 sex ratio of test population
| Sex | For male | Woman | In total (human) |
| Ratio (%) | 49.8 | 50.2 | 100 |
C. Pre-medication symptoms: before administration, 99.6% of diet, mental and physiological state are normal, 0.4% of the patients suffer from common cold, and the body has uncomfortable symptoms, as shown in Table 4.
TABLE 4 physical signs of the test population before administration
3. The administration scheme is as follows: decocting the Chinese medicinal decoction in Tianda restaurant, and orally taking one dose every day, wherein 1 bag (2 bags each dose, 180 mL/bag) is respectively taken in the afternoon, and the decoction is taken warm after meals. It is recommended to take the medicine for 3-5 days continuously.
4. The inquiry method comprises the following steps: filling in a follow-up table of taking conditions of the traditional Chinese medicines on site by (1); (2) collecting call return information; (3) and collecting data of the mobile phone electronic questionnaire.
5. The results of the administration curative effect and the associated information are shown in Table 5.
TABLE 5 statistical table of the results of the curative effect and associated information of the administration
To summarize: after the medicine is taken for 3 days, the proportion of the patients with good physical symptom reaction is 92.4 percent; 7.6 percent of people with adverse reactions and discomfort; wherein, after the cold patient takes the medicine continuously for 7 days (dose), the cold patient basically recovers to be normal without discomfort. After the medicine is taken for 2 weeks to 1 month, the patients with cold and new crown infection are not existed.
6. Adverse reactions after three days of administration are shown in Table 6.
TABLE 6 adverse reactions after three days of administration
And (3) analysis: the medicine has certain purgation effect, and may be analyzed for patients sensitive to radix et rhizoma Rhei or patients with cold constitution; other malaise reactions are related to the physical condition or individual constitution and diet of the day of the administration.
7. Two weeks after dosing: the patient does not have cold or new coronary pneumonia infection when asked by telephone, and the specific table is shown in table 7.
TABLE 7 health status of the test population after two weeks of dosing
| Symptoms and signs | Influenza | Infection with new coronary pneumonia | Other discomfort |
| Number of people (human) | 0 | 0 | 0 |
8. After one month of administration: the patients were asked to find that cold or new coronary pneumonia did not appear, as shown in Table 8.
TABLE 8 health status of the test population one month after taking the drug
| Symptoms and signs | Influenza | Infection with new coronary pneumonia | Other discomfort |
| Number of people (human) | 0 | 0 | 0 |
9. Example (c):
a man in Hubei province, aged 57 years old, weighing 73 kg, suffered from cold before taking the decoction, had poor sleep and abnormal stool, and continuously taking 7 doses of the decoction can cure the cold, has normal stool and improves sleep. After the medicine is taken for 1 month in follow-up visit, all indexes of physical symptoms are not abnormal, and new crowns and cold are not infected.
And (4) conclusion: the traditional Chinese medicine composition provided by the invention is taken as a medicine for preventing cold or neocoronary pneumonia, has a certain effect, and is used with cautions for patients with spleen-stomach deficiency cold or loose stool. The Chinese medicinal composition is more suitable for taking after meals.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.
Claims (10)
1. A traditional Chinese medicine composition for treating neocoronary pneumonia and/or influenza is characterized by comprising the following components in parts by weight: 5-30 parts of astragalus membranaceus, 5-30 parts of radix puerariae, 5-30 parts of radix bupleuri, 5-30 parts of honeysuckle, 5-30 parts of fructus forsythiae, 5-30 parts of agastache rugosus, 2-20 parts of Dahuang processed with wine, 5-30 parts of platycodon grandiflorum, 3-30 parts of raw epimedium, 5-30 parts of fried rhizoma atractylodis, 5-30 parts of radish seed, 3-20 parts of dried orange peel, 5-30 parts of white paeony root, 5-30 parts of poria cocos, 3-20 parts of mint and 2-20 parts of liquorice.
2. The traditional Chinese medicine composition according to claim 1, which is characterized by comprising the following components in parts by weight: 10-25 parts of astragaloside IV, 10-25 parts of radix puerariae, 10-25 parts of radix bupleuri, 10-25 parts of honeysuckle, 10-25 parts of fructus forsythiae, 10-25 parts of agastache rugosus, 6-16 parts of Dahuang processed with wine, 10-25 parts of platycodon grandiflorum, 10-24 parts of raw epimedium, 10-25 parts of fried rhizoma atractylodis, 10-25 parts of flatfish radish seed, 7-16 parts of dried orange peel, 10-25 parts of white paeony root, 10-25 parts of poria cocos, 10-17 parts of mint and 8-17 parts of liquorice.
3. The traditional Chinese medicine composition according to claim 1, which is characterized by comprising the following components in parts by weight: 18 parts of astragalus mongholicus, 15 parts of radix puerariae, 15 parts of radix bupleuri, 18 parts of honeysuckle, 15 parts of fructus forsythiae, 20 parts of wrinkled gianthyssop herb, 12 parts of yellow rhubarb, 18 parts of platycodon grandiflorum, 17 parts of raw epimedium herb, 18 parts of fried rhizoma atractylodis, 18 parts of fry radish seed, 12 parts of dried orange peel, 17 parts of white paeony root, 18 parts of poria cocos, 13 parts of mint and 13 parts of liquorice.
4. The preparation method of the traditional Chinese medicine composition as claimed in any one of claims 1 to 3, which is characterized by comprising the following steps:
1) distilling herba Agastaches and herba Menthae with steam to extract volatile components to obtain herba Agastaches and herba Menthae distillate;
2) radix astragali, radix Puerariae, bupleuri radix, flos Lonicerae, fructus forsythiae, herba et Gemma Agrimoniae processed with wine, radix Platycodi, herba Epimedii, rhizoma Atractylodis parched, semen Raphani, pericarpium Citri Tangerinae, radix Paeoniae alba, Poria and Glycyrrhrizae radix by extracting medicinal active ingredients with water to obtain water extractive solution;
3) mixing the agastache rugosus and mint distillate with the water extraction liquid medicine, and concentrating to obtain a traditional Chinese medicine composition;
there is no chronological restriction between step 1) and step 2).
5. The method according to claim 4, wherein the ratio of the total mass of the Agastache rugosa and Mentha haplocalyx to the volume of the water used for steam in step 1) is 1 g: 4-8 mL; the distillation and extraction time is 4-6 h.
6. The method according to claim 4, wherein the number of times of the extraction in the step 2) is 2;
during extraction for the 1 st time, the volume ratio of the total mass of the astragalus, the kudzuvine root, the radix bupleuri, the honeysuckle, the forsythia, the rhubarb processed with wine, the platycodon root, the raw epimedium herb, the fried rhizoma atractylodis, the radish seed blown, the dried orange peel, the white paeony root, the tuckahoe and the liquorice to the water is 1 g: 8-12 mL; the time for the 1 st extraction is 1-2 h;
in the 2 nd extraction, mixing the residue obtained in the 1 st extraction with water; the mass of the dregs of a decoction and the volume ratio of water are 1 g: 6-8 mL; the time for the 2 nd extraction is 1-1.5 h;
the temperature of the two extractions is 80-100 ℃;
concentrating in the step 3) until the volume ratio of the crude drug to the liquid medicine is 1: 1.
7. the preparation method according to claim 4, wherein the step 3) of concentrating further comprises adding ethanol to the obtained concentrated liquid medicine until the volume concentration reaches 50-80%, purifying, collecting the supernatant, and removing ethanol to obtain the Chinese medicinal composition.
8. The preparation method according to any one of claims 4 to 7, wherein when the dosage form of the Chinese medicinal composition is a solid preparation, the supernatant from which ethanol is removed is sequentially concentrated, dried and pulverized to obtain a powder;
when the solid preparation is dispersant or granule, the medicinal powder is directly subpackaged to obtain;
when the solid preparation is capsule, filling the medicinal powder into hollow hard capsule, and making into capsule;
when the solid preparation is a tablet, mixing the medicinal powder with tablet adjuvants, and tabletting to obtain tablet;
when the solid preparation is pill, mixing the medicinal powder, pill adjuvants and binder, and making into watered pill, honeyed pill, watered honeyed pill, concentrated pill, paste pill or wax pill;
the weight of the medicinal powder is calculated by 100 percent, the adding weight of pill auxiliary materials is 20 to 40 percent and the adding weight of adhesive is 3 to 10 percent.
9. The preparation method according to any one of claims 4 to 7, wherein when the dosage form of the traditional Chinese medicine composition is an aqueous solution, the supernatant from which ethanol is removed is concentrated and then directly subpackaged into decoction, or the supernatant is concentrated to obtain a concentrated solution, and the concentrated solution is blended to obtain an oral liquid;
the mass ratio of the concentrated solution to the blending auxiliary materials is (1-4): (6-9); the auxiliary materials for blending comprise sucrose and/or honey;
the concentration degree is that the relative density of the supernatant is 1.1-1.30 when the supernatant is concentrated to 50 ℃.
10. The preparation method of any one of claims 4 to 7, wherein when the dosage form of the Chinese medicinal composition is a dripping pill, the supernatant from which the ethanol is removed and a dripping pill substrate are heated, melted, mixed uniformly, dropped into immiscible condensate, and then contracted and condensed to prepare the dripping pill.
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| CN114588208A (en) * | 2022-02-14 | 2022-06-07 | 珠海天大中医药研究开发有限公司 | Traditional Chinese medicine extract and compound medicine for treating common cold in four seasons and influenza as well as preparation method and application of traditional Chinese medicine extract and compound medicine |
| CN116036165A (en) * | 2022-12-12 | 2023-05-02 | 中国人民解放军联勤保障部队第九八0医院 | Traditional Chinese medicine composition for treating novel coronavirus and preparation method thereof |
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| CN114588208A (en) * | 2022-02-14 | 2022-06-07 | 珠海天大中医药研究开发有限公司 | Traditional Chinese medicine extract and compound medicine for treating common cold in four seasons and influenza as well as preparation method and application of traditional Chinese medicine extract and compound medicine |
| CN116036165A (en) * | 2022-12-12 | 2023-05-02 | 中国人民解放军联勤保障部队第九八0医院 | Traditional Chinese medicine composition for treating novel coronavirus and preparation method thereof |
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