CN116036165A - Traditional Chinese medicine composition for treating novel coronavirus and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating novel coronavirus and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating novel coronaviruses, which comprises the following components in parts by weight, 60-90 parts of astragalus mongholicus and 75-110 parts of dried orange peel. Preferably, the honeysuckle flower tea also comprises 20-30 parts by weight of honeysuckle flower. The invention also discloses a preparation method of the traditional Chinese medicine composition, and the traditional Chinese medicine composition is prepared from water decoction. The invention has the advantages of short treatment time, quick recovery, obvious effect, and convenient use, low economic cost and convenient use for the masses, and can be obtained by using two to three components and decocting without matching various raw materials.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for treating novel coronaviruses and a preparation method thereof.
Background
At present, a novel traditional Chinese medicine composition with a simple preparation method for coronavirus convalescence is lacking. In order to better exert the effect of traditional Chinese medicine treatment, the research and development of medicines for treating novel coronaviruses, which has the advantages of simple method, good effect and convenient application, popularization and use, is urgently needed.
Disclosure of Invention
In order to overcome the defects of the prior art, the invention provides a traditional Chinese medicine composition for treating novel coronaviruses and a preparation method thereof, and the traditional Chinese medicine composition has simple formula and preparation method, good effect and convenient popularization and popularization.
The technical scheme adopted by the invention is as follows:
the invention discloses a traditional Chinese medicine composition for treating novel coronaviruses, which comprises the following components in parts by weight, 60-90 parts of astragalus mongholicus and 75-110 parts of dried orange peel.
Further, it comprises the following components in parts by weight, 75 parts of astragalus and 100 parts of dried orange peel.
Further, the honeysuckle flower tea also comprises 20-30 parts by weight of honeysuckle flower.
Further, the traditional Chinese medicine comprises the following components in parts by weight, 65 parts of astragalus membranaceus, 90 parts of dried orange peel and 25-30 parts of honeysuckle.
Further, the traditional Chinese medicine composition is prepared from water decoction.
The invention also discloses a preparation method of the traditional Chinese medicine composition, which comprises the following steps of S1, soaking astragalus and dried orange peel in water for 15-30 minutes to obtain a mixed soaked substance;
s2, boiling the mixed soaked matter, and then decocting for 20-30 minutes to obtain a first mixture;
s3, pouring out the liquid in the first mixture for standby, adding water into the rest solid for mixing, boiling and then decocting for 20-30 minutes to obtain a second mixture;
and S4, combining the liquids in the first mixture and the second mixture.
Further, in step S1, the mass of water: total mass of astragalus and dried orange peel = 10:1, a step of;
in the step S3, the mass of the added water is 5 times of the total mass of the astragalus and the dried orange peel in the step S1.
Further, in the steps S2 and S3, the stirring is intermittently carried out in the process of decoction, and the interval time is 5-10 minutes.
Further, (1) soaking radix astragali and pericarpium Citri Tangerinae in water for 15-30 min to obtain mixed soaking material; soaking flos Lonicerae in water for 15-25 min to obtain flos Lonicerae soaked product;
(2) Boiling the mixed soaking material for 10 minutes, adding the honeysuckle soaking material, and decocting for 10-20 minutes to obtain a third mixture;
(3) Pouring out the liquid in the third mixture for standby, adding water into the rest solid for mixing, boiling and decocting for 20-30 minutes to obtain a fourth mixture;
(4) The liquid of the third mixture and the liquid of the fourth mixture are combined.
Further, in the step (1), the mass ratio of each component is that: total mass of astragalus and dried orange peel = 10:1, water: honeysuckle = 5:1; in the step (2), the mass of the added water is 5 times of the total mass of the honeysuckle, the astragalus and the dried orange peel, and in the steps (2) and (3), the water is intermittently stirred in the decoction process for 5-10 minutes.
The method comprises the following steps:
radix astragali: sweet nature, warm nature, enter spleen meridian and lung meridian, tonify spleen and lung qi, benefit defensive qi, strengthen body resistance, strengthen superficies, induce diuresis to alleviate edema, remove toxicity and promote tissue regeneration.
Dried orange peel: warm, pungent and bitter in property, enters lung meridian and spleen meridian, has the effects of regulating qi, strengthening spleen, drying dampness and eliminating phlegm.
Honeysuckle flower: cold in nature, sweet in taste, enters the lung, heart and stomach meridians, and has the effects of clearing heat and removing toxicity, resisting inflammation, tonifying deficiency and treating wind.
Monarch drug: the astragalus root and the dried orange peel are used as monarch drugs, the astragalus root supplements qi of spleen and lung, strengthens healthy qi and benefits defenses, the dried orange peel regulates lung qi and moves qi to remove dampness, and the astragalus root and the dried orange peel are used for supplementing qi and regulating qi to move qi, supplementing but not stagnating, strengthening healthy qi and defending pathogenic factors.
Ministerial drugs: honeysuckle flower, flos Lonicerae, with fragrance of Gan Hanqi, can disperse wind-heat, dispel pathogenic factors, and take its auxiliary action as minister. When no honeysuckle is available in the case of medical resource deficiency, the dosage of the two monarch drugs can be increased, and the single-knife direct-entering effect of the monarch drugs is exerted.
The usage of the invention is as follows: orally taken, 1 bag at a time, 400-550 ml in one bag, 3 times a day, and 4 days as a treatment course. The invention has the main effects of: the invention is mainly used for treating and preventing novel coronavirus.
The beneficial effects of the invention are as follows:
(1) The raw materials of the invention are all purely natural Chinese herbal medicines, and have no toxic or side effect.
(2) Short treatment time, quick recovery, and obvious effect, and has the effects of tonifying qi and strengthening body resistance.
(3) Because two to three components are used, the Chinese medicinal preparation can be obtained through decoction without matching with various raw materials, and is convenient to use, low in economic cost and convenient for the masses to use.
Detailed Description
The invention provides a traditional Chinese medicine composition for treating novel coronaviruses, which comprises astragalus and dried orange peel, wherein the content of each component is shown in table 1.
TABLE 1
| Astragalus membranaceus | Dried orange peel | |
| Example 1 | 75g | 100g |
| Example 2 | 60g | 105g |
| Example 3 | 90g | 90g |
| Example 4 | 75g | 75g |
| Example 5 | 65g | 110g |
The invention provides a traditional Chinese medicine composition for treating novel coronaviruses, which comprises honeysuckle and one of astragalus and dried orange peel, wherein the content of each component is shown in table 2.
TABLE 2
| Astragalus membranaceus | Dried orange peel | Honeysuckle | |
| Example 6 | 65g | 90g | 25g |
| Example 7 | 60g | 110g | 20g |
| Example 8 | 90g | 75g | 30g |
| Example 9 | 65g | 100g | 25g |
The traditional Chinese medicine composition is prepared from water decoction, and all the embodiments 1-9 of the invention are prepared from water decoction.
The manufacturing process comprises the following steps: examples 1-5 included two components, astragalus root and dried orange peel.
The preparation method of example 1 is:
the preparation method comprises the following steps of s1, soaking astragalus and dried orange peel in water for 18 minutes to obtain a mixed soaked substance;
s2, boiling the mixed soaked matter, decocting for 24 minutes, intermittently stirring for 8 minutes to obtain a first mixture;
s3, pouring out the liquid in the first mixture for standby, adding water into the rest solid for mixing, boiling and then decocting for 30 minutes, wherein in the decocting process, the stirring is intermittently carried out for 10 minutes at intervals, and finally a second mixture is obtained;
s4, removing residues from the liquid of the first mixture and the second mixture, and then combining the liquid medicine parts, and removing residues. The solid-liquid separation and the separation of the medicine residue and the medicine liquid in the preparation process can be completed through conventional filtration.
In step S1, the mass of water: total mass of astragalus and dried orange peel = 10:1.
in the step S3, the mass of the added water is 5 times of the total mass of the astragalus and the dried orange peel in the step S1.
The preparation method of example 2 is:
s1, soaking astragalus and dried orange peel in water for 15 minutes to obtain a mixed soaked substance;
s2, boiling the mixed soaked matter, decocting for 30 minutes, intermittently stirring for 10 minutes to obtain a first mixture;
s3, pouring out the liquid in the first mixture for standby, adding water into the rest solid for mixing, boiling, decocting for 24 minutes, and intermittently stirring for 8 minutes to obtain a second mixture;
s4, combining the liquid of the first mixture and the liquid of the second mixture, obtaining a liquid medicine after combination, and removing dregs. In step S1, the mass of water: total mass of astragalus and dried orange peel = 10:1.
in the step S3, the mass of the added water is 5 times of the total mass of the astragalus and the dried orange peel in the step S1.
The preparation method of example 3 is:
s1, soaking astragalus and dried orange peel in water for 30 minutes to obtain a mixed soaked substance;
s2, boiling the mixed soaked matter, and then decocting for 20 minutes, wherein the mixed soaked matter is intermittently stirred for 5 minutes to obtain a first mixture;
s3, pouring out the liquid in the first mixture for standby, adding water into the rest solid for mixing, boiling, decocting for 20 minutes, and intermittently stirring for 5 minutes to obtain a second mixture;
and S4, combining the liquid of the first mixture and the liquid of the second mixture.
In step S1, the mass of water: total mass of astragalus and dried orange peel = 10:1.
in the step S3, the mass of the added water is 5 times of the total mass of the astragalus and the dried orange peel in the step S1.
The preparation method of examples 6-9 is: examples 6-9 include three components, astragalus root, dried orange peel and honeysuckle flower.
The preparation method of the embodiment 6 comprises the following steps of (1) soaking astragalus and dried orange peel in water for 20 minutes to obtain a mixed soaked substance; soaking flos Lonicerae in water for 20 min to obtain flos Lonicerae soaked product;
(2) Boiling the mixed soaking material for 10 minutes, adding the honeysuckle soaking material, and decocting for 20 minutes, wherein in the process of decoction, the mixed soaking material is intermittently stirred for 10 minutes at intervals, and finally a third mixture is obtained;
(3) Pouring out the liquid in the third mixture for standby, adding water into the rest solid for mixing, boiling and decocting for 24 minutes, and intermittently stirring for 8 minutes at intervals for 3 times to finally obtain a fourth mixture;
(4) The liquid of the third mixture and the liquid of the fourth mixture are combined.
In the step (1), the mass ratio of each component is as follows: total mass of astragalus and dried orange peel = 10:1, water: honeysuckle = 5:1;
in the step (2), the mass of the added water is 5 times of the total mass of the honeysuckle, the astragalus and the dried orange peel.
The preparation method of the embodiment 7 comprises the following steps of (1) soaking astragalus and dried orange peel in water for 15 minutes to obtain a mixed soaked substance; soaking flos Lonicerae in water for 25 min to obtain flos Lonicerae soaked product;
(2) Boiling the mixed soaking material for 10 minutes, adding the honeysuckle soaking material, continuously decocting for 16 minutes, and intermittently stirring for 8 minutes in the decocting process to finally obtain a third mixture;
(3) Pouring out the liquid in the third mixture for standby, adding water into the rest solid for mixing, boiling and then decocting for 20 minutes, wherein in the decocting process, the stirring is intermittently carried out for 5 minutes at intervals, and finally a fourth mixture is obtained;
(4) The liquid of the third mixture and the liquid of the fourth mixture are combined.
In the step (1), the mass ratio of each component is as follows: total mass of astragalus and dried orange peel = 10:1, water: honeysuckle = 5:1;
in the step (2), the mass of the added water is 5 times of the total mass of the honeysuckle, the astragalus and the dried orange peel.
The preparation method of the embodiment 8 comprises the following steps of (1) soaking astragalus and dried orange peel in water for 30 minutes to obtain a mixed soaked substance; soaking flos Lonicerae in water for 15 min to obtain flos Lonicerae soaked product;
(2) Boiling the mixed soaking material for 10 minutes, adding the honeysuckle soaking material, and decocting for 10 minutes, wherein in the process of decoction, the mixed soaking material is intermittently stirred for 5 minutes at intervals, so as to finally obtain a third mixture;
(3) Pouring out the liquid in the third mixture for standby, adding water into the rest solid for mixing, boiling and decocting for 30 minutes, wherein in the decocting process, the stirring is intermittently carried out for 10 minutes at intervals, and stirring is carried out for three times to obtain a fourth mixture;
(4) The liquid of the third mixture and the liquid of the fourth mixture are combined.
In the step (1), the mass ratio of each component is as follows: total mass of astragalus and dried orange peel = 10:1, water: honeysuckle = 5:1;
in the step (2), the mass of the added water is 5 times of the total mass of the honeysuckle, the astragalus and the dried orange peel.
The application method of the invention comprises the following steps: three times a day, 400-550 ml at a time. Three times of fasting oral administration, which is a powerful anti-novel coronavirus drug. When the decoction is necessary, for example, patients have high fever with dizziness, aphasia, weak footfall instability and the like, the first three times of taking the decoction can be separated by 4-5 hours, and the later time is separated by 8 hours for taking the decoction once. The decoction has low cost and easily available medicinal taste, and is suitable for common people family treatment.
The Chinese herbal medicine composition for treating the novel coronavirus provided by the invention takes pure natural Chinese herbal medicines as raw materials, has no toxic or side effect, short treatment time, quick recovery, convenient use, low economic cost, convenient use by masses and obvious effect. In addition, the taste and smell of the patient taking the medicine of the invention are not affected during the treatment process and after the recovery.
The invention adopts the modified astragalus and dried orange peel decoction (as a special effect drug) to treat the novel coronavirus infection.
The traditional Chinese medicine composition provided by the invention is prepared from 60-90g of astragalus membranaceus and 75-110g of dried orange peel, and 20-30g of honeysuckle is added or not added according to the requirements; in the case of no honeysuckle, most preferably, the common therapeutic amount of astragalus mongholicus 75 g+dried orange peel 100g, and in the case of adding honeysuckle, most preferably, 25g of honeysuckle+the common therapeutic amount of astragalus mongholicus 65 g+dried orange peel 90g. The novel coronavirus infection effect is remarkable in clinic treatment by taking a large amount of astragalus and dried orange peel as basic prescription, and the body temperature drop, headache and muscular soreness are relieved after the decoction is orally taken for 3-4 hours at the initial stage of symptoms or at the time of the biggest symptoms, and the body temperature returns to be normal and the headache and muscular soreness disappear after the decoction is orally taken for about 12 hours. The time for eliminating symptoms is obviously shortened after the decoction is applied, and even no fever occurs when a part of patients take the decoction when the patients have symptoms slightly in the first day, so that the treatment effect is obviously higher than that of the decoction, the Chinese patent medicines and the western medicines which are clinically applied at present.
The formula has only two to three medicines, is simple, takes the effect of directly taking the medicine flavor by a single knife, and has strong antiviral activity, low cost and strong practicability.
The invention can change the symptoms of conventional morbidity after the medicine is taken, and reduce the occurrence of symptoms such as high fever, pain and the like.
The cost of the invention is far lower than that of the medicine in the prior art, and referring to the existing market price, the cost of the invention is 25 yuan for 1000g of astragalus, 15 yuan for 1000g of dried orange peel and 135 yuan for 1000g of honeysuckle, and the cost of one person is only 6-7 yuan a day, thus greatly saving the economic cost and medical resources.
The formula mechanism of the invention is described:
(1) Astragalus root and dried orange peel are all common clinical traditional Chinese medicines, the main components of astragalus root (having the effects of sweet nature, warming spleen channel, lung channel, tonifying lung qi and spleen qi, tonifying defensive qi, consolidating exterior, inducing diuresis to alleviate edema, expelling toxin, promoting granulation and the like), the main components of dried orange peel (having the effects of regulating qi, strengthening spleen, eliminating dampness and eliminating phlegm, and having the effects of regulating qi, strengthening spleen) are flavonoid substances and volatile oil, wherein the volatile oil is an invalid component for treatment and is partially removed in the long-time decoction process. The astragalus root and the dried orange peel are used as monarch drugs, the astragalus root supplements qi of spleen and lung, strengthens healthy qi and benefits defenses, the dried orange peel regulates lung qi and moves qi to remove dampness, and the astragalus root and the dried orange peel are used for supplementing qi and regulating qi to move qi, supplementing but not stagnating, strengthening healthy qi and defending pathogenic factors. The recipe has the effects of invigorating qi, strengthening body resistance, and strengthening body resistance. 4 days is a course of treatment, and can be used for treating and preventing novel coronaviruses.
In the recipe, honeysuckle flower is fragrant Gan Hanqi and is known from ancient times as a good medicine for clearing heat and detoxicating, dispersing wind-heat, eliminating pathogenic factors through the recipe and taking its auxiliary effect.
Honeysuckle is used as a ministerial drug. When no ministerial drug of honeysuckle is available, the two monarch drugs also have the efficacy of single knife direct entering. The honeysuckle has an auxiliary effect, and when the dosage of the astragalus and the dried orange peel is too large, such as obesity and hypertension, the honeysuckle can be used for replacing some dosage of the astragalus.
Pericarpium Citri Reticulatae can be used for treating hundred diseases by taking its effects of regulating qi and eliminating dampness, tonifying with tonic, purging with cathartic, ascending with ascending, descending with ascending, invigorating qi and yang, strengthening the body resistance, inducing diuresis and relieving edema. It can regulate blood vessels, flow meridians and collaterals, promote the growth of body surface, prevent sweating.
Dialectical: can be used for treating qi deficiency and defensive weakness, invasion of exogenous evil, phlegm retention, and cough due to excessive phlegm caused by deficiency of qi, deficiency of vital energy, deficiency of defensive qi, exterior deficiency, and pathogenic qi.
Taboo: a patient suffering from allergy to traditional Chinese medicine; patients with hemorrhage of digestive tract.
(2) The invention creatively selects two common traditional Chinese medicine components, obtains better effect than the conventional complex formula through compatibility and preparation of specific proportion, and has synergistic effect on treating novel coronavirus, especially the amikacin toxin after the astragalus and the dried orange peel are compatible.
Astragalus root, radix astragali is the long term tonic, tonifying qi and defensive qi, strengthening the body resistance and consolidating the exterior. Dried orange peel can regulate qi, invigorate spleen, dry dampness and eliminate phlegm. The two are used together to tonify qi, regulate qi and promote qi circulation, tonify without stagnation, strengthen body resistance and defend pathogenic factors. The recipe has the effects of invigorating qi, strengthening body resistance, and strengthening body resistance. The radix astragali contains saponin and isoflavone as main ingredients, wherein the calycosin and calycosin are decomposed into monosaccharide and calycosin by microbial enzymes in digestive tract, and the calycosin can be absorbed by passive diffusion. The main components of pericarpium Citri Tangerinae are flavonoids and volatile oil, wherein the volatile oil is the inactive component for treatment, and is partially removed during long-time decoction, wherein hesperidin, hesperetin, olein and neohesperidin are the main flavonoids, and hesperidin, naringin and neohesperidin are decomposed into hesperetin and naringenin by digestive tract microbial enzymes, and hesperetin and naringenin are absorbed by organism in a passive diffusion manner. Flavonoid glycosides are difficult to be absorbed by the body due to their high polarity.
In the invention, flavonoid compounds in the dried orange peel can prolong the serum half-life of calycosin in the astragalus, and the aim of prolonging the in-vivo half-life of the main active ingredient calycosin in the astragalus can be achieved by adopting a certain dosage when the astragalus and the dried orange peel are used together, thereby improving the curative effect.
At present, the technical scheme of the invention has been subjected to pilot-scale experiments, namely small-scale experiments of products before large-scale mass production; after the pilot test is completed, the use investigation of the user is performed in a small range, and the investigation result shows that the user satisfaction is higher; now, the preparation of the formal production of the product for industrialization (including intellectual property risk early warning investigation) is started.
The above-described embodiments are preferred examples of the invention and are not exhaustive of the possible implementations of the invention. Various modifications of the invention, which are apparent to those skilled in the art, should be deemed to be within the scope of the invention as defined by the appended claims.
Claims (10)
1. A traditional Chinese medicine composition for treating novel coronaviruses is characterized by comprising the following components in parts by weight, 60-90 parts of astragalus mongholicus and 75-110 parts of dried orange peel.
2. The traditional Chinese medicine composition for treating novel coronaviruses according to claim 1, which is characterized by comprising the following components in parts by weight, 75 parts of astragalus mongholicus and 100 parts of dried orange peel.
3. The traditional Chinese medicine composition for treating novel coronaviruses according to claim 1, further comprising honeysuckle, wherein the weight parts of the honeysuckle are 20-30.
4. The traditional Chinese medicine composition for treating novel coronaviruses according to claim 3, which is characterized by comprising the following components in parts by weight, 65 parts of astragalus mongholicus, 90 parts of dried orange peel and 25-30 parts of honeysuckle.
5. The traditional Chinese medicine composition for treating novel coronaviruses according to claim 1, wherein the traditional Chinese medicine composition is in the form of decoction.
6. A preparation method of a traditional Chinese medicine composition for treating novel coronaviruses is characterized by comprising the following steps,
s1, soaking astragalus and dried orange peel in water for 15-30 minutes to obtain a mixed soaked substance;
s2, boiling the mixed soaked matter, and then decocting for 20-30 minutes to obtain a first mixture;
s3, pouring out the liquid in the first mixture for standby, adding water into the rest solid for mixing, boiling and then decocting for 20-30 minutes to obtain a second mixture;
and S4, combining the liquids in the first mixture and the second mixture.
7. The method for preparing a traditional Chinese medicine composition for treating novel coronaviruses according to claim 6, wherein in step S1, the mass of water is: total mass of astragalus and dried orange peel = 10:1, a step of;
in the step S3, the mass of the added water is 5 times of the total mass of the astragalus and the dried orange peel in the step S1.
8. The method of preparing a pharmaceutical composition for treating novel coronaviruses of claim 6, wherein steps S2 and S3 are performed with intermittent stirring for 5-10 minutes.
9. The method for preparing a Chinese medicinal composition for treating novel coronaviruses according to claim 6, comprising the steps of (1) soaking astragalus and dried orange peel in water for 15-30 minutes to obtain a mixed soaked product; soaking flos Lonicerae in water for 15-25 min to obtain flos Lonicerae soaked product;
(2) Boiling the mixed soaking material for 10 minutes, adding the honeysuckle soaking material, and decocting for 10-20 minutes to obtain a third mixture;
(3) Pouring out the liquid in the third mixture for standby, adding water into the rest solid for mixing, boiling and decocting for 20-30 minutes to obtain a fourth mixture;
(4) The liquid of the third mixture and the liquid of the fourth mixture are combined.
10. The method for preparing a traditional Chinese medicine composition for treating novel coronaviruses according to claim 9, wherein in the step (1), the mass ratio of each component is: total mass of astragalus and dried orange peel = 10:1, water: honeysuckle = 5:1;
in the step (2), the mass of the added water is 5 times of the total mass of the honeysuckle, the astragalus and the dried orange peel, and in the steps (2) and (3), the water is intermittently stirred in the decoction process for 5-10 minutes.
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| CN111714553A (en) * | 2020-06-23 | 2020-09-29 | 天大药业（珠海）有限公司 | A Chinese medicinal composition for treating new coronary pneumonia and/or influenza, and its preparation method |
| CN115227704A (en) * | 2022-08-18 | 2022-10-25 | 天津中医药大学 | Application of hesperidin in preparation of medicine for preventing and/or treating infection of novel Ormckhue coronavirus variant strain |
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| CN111714553A (en) * | 2020-06-23 | 2020-09-29 | 天大药业（珠海）有限公司 | A Chinese medicinal composition for treating new coronary pneumonia and/or influenza, and its preparation method |
| CN115227704A (en) * | 2022-08-18 | 2022-10-25 | 天津中医药大学 | Application of hesperidin in preparation of medicine for preventing and/or treating infection of novel Ormckhue coronavirus variant strain |
Non-Patent Citations (2)
| Title |
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| YUAN-CHIEH YEH等: "Honeysuckle (Lonicera japonica) and Huangqi (Astragalus membranaceus) Suppress SARS-CoV-2 Entry and COVID-19 Related Cytokine Storm in Vitro", FRONTIERS IN PHARMACOLOGY, vol. 12, no. 3, pages 2 * |
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