CN100411670C - Medicine for treating tumor in upper digestive tract and its preparing method - Google Patents
Medicine for treating tumor in upper digestive tract and its preparing method Download PDFInfo
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- CN100411670C CN100411670C CNB2006100387452A CN200610038745A CN100411670C CN 100411670 C CN100411670 C CN 100411670C CN B2006100387452 A CNB2006100387452 A CN B2006100387452A CN 200610038745 A CN200610038745 A CN 200610038745A CN 100411670 C CN100411670 C CN 100411670C
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Abstract
The present invention relates to a medicine for treating the upper gastrointestinal tract, which comprises the raw materials of the following proportion by weight: white atractylodes rhizome, Chinese yam, rehmannia root, belvedere fruit, bitter orange, coix seed, poria from yunnan of China, spina date seed, magnolia barks and licorice root. The present invention is on the foundation of maintaining organism autologous disease resistance, takes nourishing and harmonizing the stomach and strengthening vital qi to eliminate pathogenic factor as principle, adopts traditional Chinese medicinal materials, takes white atractylodes rhizome and the Chinese yam as a sovereign medicine, takes the bitter orange and the poria from yunnan of China as a minister medicine, takes the magnolia barks, spina date seed, rehmannia root, coix seed and licorice root as an envoy medicine, and takes the belvedere fruit as a medicine for enhancing the efficacy of medicine. The present invention aims at treating oesophagus cancer and the pain generated before and after the oesophagus cancer radiotherapy, and angelica, chuanxiong rhizome and haw are added into the raw materials. The present invention has the advantages of precise formula, appropriate compounded and no relation of the compounds to cause the inner efficiency of strengthening vital qi to eliminate pathogenic factor to be fully exerted, and has the obvious functions of promoting the circulation of qi, dissipating blood stasis, resolving masses and expelling toxin. The present invention has the favorable curative effects of treating upper digestive tract tumor, such as esophagus cancer, carcinoma of gastric cardia and gastric cancer.
Description
Technical field
The present invention relates to a kind of Chinese herbal medicine, particularly a kind of medicine for the treatment of the tumor in upper digestive tract of esophageal carcinoma, carcinoma of gastric cardia, gastric cancer.
The invention still further relates to a kind of preparation method of this medicine.
Background technology
Digestive tract tumor is the common frdquently encountered disease of serious harm human health, and mortality rate is very high, and tumor in upper digestive tract comprises esophageal carcinoma, carcinoma of gastric cardia, gastric cancer.The medicine that is used for the treatment of at present upper digestive tract cancer at home and abroad is a lot, but the western medicine side effect is big, has the phenomenon of a lot of over-treatments.In traditional Chinese medicine preparation, much all exist curative effect low, the problem that the course of treatment is long, the heavy dose of medication that has, the long-term prescription that has, the compatibility that has is unreasonable, the treating the poisonous disease with poisonous drugs that has, all objective reality is damaged body vigour, the Wei Zhiqi of battalion, the phenomenon of over-treatment occurs.
Summary of the invention
The technical problem to be solved in the present invention is at the deficiencies in the prior art, the medicine of the treatment tumor in upper digestive tract that proposed a kind of good effect, has no side effect.
Another technical problem that will solve of the present invention is a kind of preparation method that discloses this medicine.
Human society is in continuous development, and the sickness rate of various pathological changes, tumor is more and more higher, and is especially high with the number of the infected of the esophageal carcinoma of upper digestive tract, carcinoma of gastric cardia, gastric cancer.Its main cause is, human dietary structure becomes increasingly complex, Di Li artificial destruction in addition, weather, environment, water source, food, plant etc. be by the extensive pollution of various chemical oxious components, and the depression of human colony, individual emotion, influence such as fidgety, cause irritability liver-fire rising in the body, cause human body operation functional activity of QI being not smooth, metabolic imbalance, gastrointestinal are taken in toxin that digestion discharges and can not be detoxified smoothly to arrange and rush down, condense with irritability, the stasis of blood is long-pending will to develop into tumor to certain position.The stasis of blood is amassed in upper digestive tract will form esophageal carcinoma or gastric cancer or carcinoma of gastric cardia.According to this pathogeny, cardinal principle of the present invention is exactly to utilize the flavor efficacy of Chinese medicine, and bleed is descending, sets about from the source of treatment cancer, based on conditioning liver stomach, strengthening vital QI to eliminate pathogenic factors, blood stasis dispelling toxin expelling, treatment cancer.
The technical problem to be solved in the present invention is achieved through the following technical solutions, and a kind of medicine for the treatment of tumor in upper digestive tract is characterized in: it is by the medicament that comprises that following raw materials by weight proportions is made,
The Rhizoma Atractylodis Macrocephalae 10～60 Rhizoma Dioscoreaes 10～60 Radix Rehmanniae 10～30
The Fructus Kochiae 10～30 Fructus Aurantiis 10～60 Semen Coiciss 10～60
Poria 10～60 Semen Ziziphi Spinosaes 10～60 Cortex Magnoliae Officinalis 10～60
Radix Glycyrrhizae 5～20.
The technical problem to be solved in the present invention can also be come further realization by the following technical programs, and it is the medicament of being made by following raw materials by weight proportions,
The Rhizoma Atractylodis Macrocephalae 10～60 Rhizoma Dioscoreaes 10～60 Radix Rehmanniae 10～30
The Fructus Kochiae 10～30 Fructus Aurantiis 10～60 Semen Coiciss 10～60
Poria 10～60 Semen Ziziphi Spinosaes 10～60 Cortex Magnoliae Officinalis 10～60
Radix Glycyrrhizae 5～20 Radix Angelicae Sinensis 10～60 Rhizoma Chuanxiongs 10～60
Fructus Crataegi 10～60.
This policy is to the pain therapy before and after the esophageal carcinoma and the esophageal carcinoma radiotherapy, and relieving pain is especially better to the therapeutic effect of female patient.
The technical problem to be solved in the present invention can also come to realize that further pharmaceutical dosage form of the present invention is an oral formulations by the following technical programs.As: oral liquid, full dissolved granule, powder, tablet, pill etc., tablet can also be made coated tablet, gelatin foil.Preferred oral liquid and full dissolved granule dosage form.
Dosage form of the present invention is an oral liquid, and its preparation method is: take by weighing authentic medicinal herbs, the accurate extraction is because the active ingredient good water solubility of all medical materials so adopt water or alcohol to make solvent, adopts decocting method extraction or percolation or circumfluence method to extract.The technical program adopts the traditional water decoction to extract.With 5～10 times of water gagings medical material was soaked 2～4 hours, decocted 2 hours for the first time, will often stir in the decoction process, double gauze filters; For the second time decoct with water 1 hour, will often stir in the decoction process, prevent to stick with paste at the end, double gauze filters; Merging filtrate, three layers of gauze secondary filter of reuse, an amount of concentrating, the metering packing gets oral liquid.
Usage and consumption: a twice-daily, morning and evening (medicine) being taken before meal usefulness, the suitable 15～30g crude drug of a 150～250ml amount.
Dosage form of the present invention is full granule, and its preparation method is: take by weighing authentic medicinal herbs, with 5～10 times of water gagings medical material was soaked 2～4 hours, decocted 2 hours for the first time, will often stir in the decoction process, double gauze filters; For the second time decoct with water 1 hour, will often stir in the decoction process, prevent to stick with paste at the end, double gauze filters; Merging filtrate, three layers of gauze secondary filter of reuse, concentrate extractum, cool, make soft material with dried starch, with 14～16 mesh sieve system granules, 60 degree are following dries, 10 mesh sieve granulate, the weighing packing gets final product.
Usage and consumption: a twice-daily, morning and evening (medicine) being taken before meal usefulness, 15～30g crude drug amount.
Points for attention:
1, necessary decoction being taken warmly, (medicine) being taken before meal is used;
2, diet Cyprinus carpio, cock, Carnis Sus domestica and pungent, frying, raw food;
3, period in a medicine diet Semen phaseoli radiati and goods thereof;
4, the hyperglycemic patients period in a medicine reduces the intake of carbohydrate;
5, take a good rest and note warmingly, note Changes in weather, prevent that physically-draining from causing flu, keep mood optimistic.
The present invention is the basis from the resistance against diseases of safeguarding body self, and with the nourishing the stomach stomach function regulating, strengthening vital QI to eliminate pathogenic factors is a principle, selecting genuine Chinese crude drug for use, is monarch with the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae, and Fructus Aurantii, Poria are for being minister, assistant is with Cortex Magnoliae Officinalis, Semen Ziziphi Spinosae, the Radix Rehmanniae, Semen Coicis, Radix Glycyrrhizae, with the Fructus Kochiae for drawing.Its prescription is rigorous, and compatibility is proper, and not irrelevant composition makes the specific efficacy performance of its strengthening vital QI to eliminate pathogenic factors perfect, the circulation of qi promoting dissipating blood stasis, and the transforming calculus, eliminating toxin effect is remarkable, can reach the purpose of control tumor symptom in the medication short time, thereby heal the sick.
Pharmaceutical test:
One, animal acute toxicity experiment
Carry out acute toxicity test with mice and rat respectively, (5g crude drug/ml) irritate stomach (ig) medicament of the present invention three times on the one with maximum administration volume (mice 0.4ml/10g body weight, rat 2ml/100g body weight) is observed a week with Cmax.The result is none routine animal dead in experimentation, does not also have any toxic reaction, and gastric infusion can not surveyed the median lethal dose(LD 50) (LD of this medicament
50), recording three gastric infusion maximum tolerated doses (MTD) in a day, rat is 600g crude drug/kg, mice is 300g crude drug/kg, is equivalent to respectively be grown up intend 200 times and 100 times of clinical consumption per day.
Two, long-term toxicity test for animals
With the WISTAR rat medicament of the present invention is carried out long term toxicity test, divide high, medium and low three dosage (100g crude drug/kg, 30g crude drug/kg, 10g crude drug/kg, calculate by kg body weight, 40 times, 12 times, 4 times of clinical consumption per day are equivalent to respectively to be grown up), once a day, gastric infusion is 90 days continuously, continues after the drug withdrawal of part animal to see 14 days.Observe through general situation, hematological indices, blood parameters, gross anatomy and histopathology are observed, and the result shows that the medication animal blood glucose slightly raises (p＜0.05) than matched group, other non-evident sympton.Illustrating that this medicament is without any side effects, is safe in the normal clinical scope of application.
Three, analgesic activity
Get 60 of mices, male, be divided into 4 groups at random by body weight, divide high, medium and low three dosage groups and matched group, behind high, medium and low three dosage group gastric infusions, each organizes the acetum 0.2ml/20g of the equal lumbar injection 0.7% of mice, observing behind the injection acetic acid in 10 minutes mice the writhing response number of times occurs and (stretches hind leg, abdominal part shrinks indent, and arm is raised), and calculate suppression ratio.
| The dosage group | Ulcer index (X ± SD) | Suppression ratio (%) |
| Matched group | 25.38±8.23 | |
| Low dose group | 18.46±6.94 | 27.3 |
| Middle dosage group | 17.74±6.55 | 36.8 |
| High dose group | 15.29±5.11 | 39.8 |
The result shows, medicine of the present invention has an obvious suppression effect to mice acetic acid is pain caused.
Clinical practice
For showing that medicament of the present invention comprises the therapeutic effect of esophageal carcinoma, carcinoma of gastric cardia, gastric cancer to tumor in upper digestive tract, with medicament of the present invention 133 routine patients are carried out system's clinical observation, wherein carcinoma of gastric cardia 38 examples, the esophageal carcinoma 65 examples, gastric cancer 30 examples, male's 88 examples wherein, women's 45 examples, its curative effect statistical result is as follows:
After morning person took medicine 12 hours, belch, feel sick, symptoms of emesis improves, and tells a large amount of mucus symptoms after 48 hours and is improved or controls, after the course of treatment, the good person of effect just can advance general food.
The pain relieving situation: taking this medicine all has inhibitory action in various degree to patient's chest pain, back pain, precordialgia, stomachache.
Effective percentage sees the following form:
Showing that from above clinical statistics data the present invention comprises that to tumor in upper digestive tract the therapeutic effect of esophageal carcinoma, carcinoma of gastric cardia, gastric cancer is obvious, is a kind of good medicine of treatment tumor in upper digestive tract.
The specific embodiment
Embodiment 1, a kind of medicine for the treatment of tumor in upper digestive tract, and it is by the medicament that comprises that the following weight proportion raw material is made, the present embodiment dosage form is an oral liquid.
The Rhizoma Atractylodis Macrocephalae 10, Rhizoma Dioscoreae 10, the Radix Rehmanniae 10, the Fructus Kochiae 10, Fructus Aurantii 10,
Semen Coicis 10, Poria 10, Semen Ziziphi Spinosae 10, Cortex Magnoliae Officinalis 10, Radix Glycyrrhizae 5.
Embodiment 2, a kind of medicine for the treatment of tumor in upper digestive tract, and it is by the medicament that comprises that the following weight proportion raw material is made, the present embodiment dosage form is full dissolved granule.
The Rhizoma Atractylodis Macrocephalae 60, Rhizoma Dioscoreae 60, the Radix Rehmanniae 30, the Fructus Kochiae 30, Fructus Aurantii 60,
Semen Coicis 60 Poria 60, Semen Ziziphi Spinosae 60, Cortex Magnoliae Officinalis 60, Radix Glycyrrhizae 20.
Embodiment 3, a kind of medicine for the treatment of tumor in upper digestive tract, and it is by the medicament that comprises that the following weight proportion raw material is made, the present embodiment dosage form is a powder.
The Rhizoma Atractylodis Macrocephalae 30, Rhizoma Dioscoreae 30, the Radix Rehmanniae 20, the Fructus Kochiae 20, Fructus Aurantii 30,
Semen Coicis 30, Poria 30, Semen Ziziphi Spinosae 30, Cortex Magnoliae Officinalis 30, Radix Glycyrrhizae 15.
Embodiment 4, a kind of medicine for the treatment of tumor in upper digestive tract, and it is by the medicament that comprises that the following weight proportion raw material is made, the present embodiment dosage form is a tablet.
The Rhizoma Atractylodis Macrocephalae 10, Rhizoma Dioscoreae 30, the Radix Rehmanniae 20, the Fructus Kochiae 20, Fructus Aurantii 30,
Semen Coicis 30, Poria 10, Semen Ziziphi Spinosae 60, Cortex Magnoliae Officinalis 60,
Radix Glycyrrhizae 5, Radix Angelicae Sinensis 60, Rhizoma Chuanxiong 60, Fructus Crataegi 60.
This policy is to the pain therapy before and after the esophageal carcinoma and the esophageal carcinoma radiotherapy, relieving pain,
Especially better to the therapeutic effect of female patient.
Embodiment 5, a kind of medicine for the treatment of tumor in upper digestive tract, and it is by the medicament that comprises that the following weight proportion raw material is made, the present embodiment dosage form is a pill.
The Rhizoma Atractylodis Macrocephalae 60, Rhizoma Dioscoreae 10, the Radix Rehmanniae 30, the Fructus Kochiae 30, Fructus Aurantii 10,
Semen Coicis 30, Poria 60, Semen Ziziphi Spinosae 30, Cortex Magnoliae Officinalis 30
Radix Glycyrrhizae 20, Radix Angelicae Sinensis 30, Rhizoma Chuanxiong 30, Fructus Crataegi 30.
Embodiment 6, a kind of medicine for the treatment of tumor in upper digestive tract, and it is by the medicament that comprises that the following weight proportion raw material is made, the present embodiment dosage form can also be made coated tablet, gelatin foil.
The Rhizoma Atractylodis Macrocephalae 30, Rhizoma Dioscoreae 60, the Radix Rehmanniae 10, the Fructus Kochiae 10, Fructus Aurantii 10,
Semen Coicis 10, Poria 30, Semen Ziziphi Spinosae 10, Cortex Magnoliae Officinalis 10
Radix Glycyrrhizae 15, Radix Angelicae Sinensis 10, Rhizoma Chuanxiong 10, Fructus Crataegi 10.
Embodiment 7, and dosage form of the present invention is an oral liquid, and its preparation method is: take by weighing authentic medicinal herbs, the accurate extraction is because the active ingredient good water solubility of all medical materials so adopt water or alcohol to make solvent, adopts decocting method extraction or percolation or circumfluence method to extract.The technical program adopts the traditional water decoction to extract.With 5～10 times of water gagings medical material was soaked 2～4 hours, decocted 2 hours for the first time, will often stir in the decoction process, double gauze filters; For the second time decoct with water 1 hour, will often stir in the decoction process, prevent to stick with paste at the end, double gauze filters; Merging filtrate, three layers of gauze secondary filter of reuse, an amount of concentrating, the metering packing gets oral liquid.
Embodiment 8, and dosage form of the present invention is full granule, and its preparation method is: take by weighing authentic medicinal herbs, with 5～10 times of water gagings medical material was soaked 2～4 hours, decocted 2 hours for the first time, will often stir in the decoction process, double gauze filters; For the second time decoct with water 1 hour, will often stir in the decoction process, prevent to stick with paste at the end, double gauze filters; Merging filtrate, three layers of gauze secondary filter of reuse, concentrate extractum, cool, make soft material with dried starch, with 14～16 mesh sieve system granules, 60 degree are following dries, 10 mesh sieve granulate, the weighing packing gets final product.
Claims (6)
1. medicine for the treatment of tumor in upper digestive tract, it is characterized in that: it is by the medicament that comprises that following raw materials by weight proportions is made,
The Rhizoma Atractylodis Macrocephalae 10～60, Rhizoma Dioscoreae 10～60, the Radix Rehmanniae 10～30,
The Fructus Kochiae 10～30, Fructus Aurantii 10～60, Semen Coicis 10～60,
Poria 10～60, Semen Ziziphi Spinosae 10～60, Cortex Magnoliae Officinalis 10～60,
Radix Glycyrrhizae 5～20.
2. the medicine of treatment tumor in upper digestive tract according to claim 1 is characterized in that: it is the medicament of being made by following raw materials by weight proportions,
The Rhizoma Atractylodis Macrocephalae 10～60, Rhizoma Dioscoreae 10～60, the Radix Rehmanniae 10～30,
The Fructus Kochiae 10～30, Fructus Aurantii 10～60, Semen Coicis 10～60,
Poria 10～60, Semen Ziziphi Spinosae 10～60, Cortex Magnoliae Officinalis 10～60,
Radix Glycyrrhizae 5～20, Radix Angelicae Sinensis 10～60, Rhizoma Chuanxiong 10～60,
Fructus Crataegi 10～60.
3. the medicine of treatment tumor in upper digestive tract according to claim 1 and 2 is characterized in that: pharmaceutical dosage form of the present invention is an oral formulations.
4. the medicine of treatment tumor in upper digestive tract according to claim 3 is characterized in that: as: pharmaceutical dosage form of the present invention is oral liquid or full dissolved granule.
5. the medicine of the described treatment tumor in upper digestive tract of claim 3 is characterized in that, its dosage form is that the preparation method of oral liquid is: adopt decocting method to extract, with 5～10 times of water gagings medical material was soaked 2～4 hours, decocted 2 hours for the first time, will often stir in the decoction process, filter; For the second time decoct with water 1 hour, will often stir in the decoction process, prevent to stick with paste at the end, filter; Merging filtrate, secondary filter again, an amount of concentrating, the metering packing gets oral liquid.
6. the medicine of the described treatment tumor in upper digestive tract of claim 3, it is characterized in that: its dosage form is full dissolved granule, and its preparation method is: take by weighing authentic medicinal herbs, with 5～10 times of water gagings medical material was soaked 2～4 hours, decocted 2 hours for the first time, will often stir in the decoction process, filter; For the second time decoct with water 1 hour, will often stir in the decoction process, prevent to stick with paste at the end, filter; Merging filtrate, secondary filter again, concentrate extractum, cool, make soft material with dried starch, with 14～16 mesh sieve system granules, 60 degree are following dries, 10 mesh sieve granulate, the weighing packing gets final product.
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| CN100411670C true CN100411670C (en) | 2008-08-20 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101249235B (en) * | 2008-03-29 | 2010-11-03 | 李玉林 | Chinese medicine for curing esophagus cancer and method of preparing the same |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1537564A (en) * | 2003-04-17 | 2004-10-20 | 吴军杰 | Traditional chinese medicine prepns. for treating broad-spectrum cancers |
| CN1651064A (en) * | 2004-12-23 | 2005-08-10 | 黄文珍 | Medicinal composition for treating tumour and its preparation method |
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- 2006-03-05 CN CNB2006100387452A patent/CN100411670C/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1537564A (en) * | 2003-04-17 | 2004-10-20 | 吴军杰 | Traditional chinese medicine prepns. for treating broad-spectrum cancers |
| CN1651064A (en) * | 2004-12-23 | 2005-08-10 | 黄文珍 | Medicinal composition for treating tumour and its preparation method |
Non-Patent Citations (2)
| Title |
|---|
| 中医辨证论治癌痛54例. 钟毅，周红，张卫萍，江俊珊.安徽中医临床杂志，第6期. 2001 |
| 中医辨证论治癌痛54例. 钟毅，周红，张卫萍，江俊珊.安徽中医临床杂志，第6期. 2001 * |
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