CN103989619A - Anti-aging cream of lucid ganoderma and preparation method thereof - Google Patents
Anti-aging cream of lucid ganoderma and preparation method thereof Download PDFInfo
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- CN103989619A CN103989619A CN201410219028.4A CN201410219028A CN103989619A CN 103989619 A CN103989619 A CN 103989619A CN 201410219028 A CN201410219028 A CN 201410219028A CN 103989619 A CN103989619 A CN 103989619A
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Abstract
The invention discloses an anti-aging cream of lucid ganoderma. The anti-aging cream comprises 0.02-5% of component A and 0.02-5% of component B by the mass percent in the cream. The invention also discloses a preparation method of the anti-aging cream of the lucid ganoderma. The method comprises the following steps: preparing the component A, namely a water extract anti-aging active ingredient of the lucid ganoderma; preparing a component B, namely CO2 supercritical extraction anti-aging active ingredient of the lucid ganoderma; emulsifying the component A with the component B according to a certain ratio at high temperature, and then adding a base stock at high temperature to obtain the cream. The anti-aging active substance in the lucid ganoderma is effectively extracted, the active substance is applied to production of the cream, and the experiment proves that the prepared cream has the anti-aging effect, is significant in effect, and has good safety.
Description
Technical field
The present invention relates to a kind of facial cream, especially a kind of Ganoderma anti-aging face cream and preparation method thereof.
Background technology
Human senility is a kind of irreversible degradation phenomena occurring with age growth, can be divided into naturally-aged and disease old and feeble.How slow down aging and slow down the injury being brought to the mankind by disease aging, has become the study hotspot in current Medical Biology field, and has day by day received the concern of countries in the world.Along with like a raging fire the carrying out of anti-aging product research, various antiaging agents also emerge in multitude market, edible and medical fungi anti-aging product has become the new lover of research field at present, and in numerous anti-aging products, is the research of skin care item to antidotal hot research.
Ganoderma is exactly the famous and precious medicinal fungi of China since ancient times, and modern medicine research finds that Ganoderma has the immunity of enhancing, enhances metabolism, the effect such as antitumor, slow down aging.At present, Ganoderma is general as edible, as the use of anti-aging face cream, does not also have report.
Summary of the invention
One of object of the present invention is to provide a kind of new Ganoderma anti-aging face cream, experiment confirmation, and this facial cream has senile-resistant efficacy, and safety has no side effect.
A kind of Ganoderma anti-aging face cream, comprise that to account for facial cream mass percent be the composition A of 0.02%-5% and the composition B of 0.02%-5%, wherein, the preparation process of described composition A is: the Ganoderma sporophore that is 10-80:10-80:10-80 according to weight portion proportioning, Ganoderma mycelium and Ganoderma spore powder mix, in water bath with thermostatic control, carry out water extraction, concentrate drying obtains composition A; Wherein, the preparation process of described composition B is: the Ganoderma sporophore that is 10-80:10-80:10-80 according to weight portion proportioning, Ganoderma mycelium and Ganoderma spore powder mix, and pulverize supercritical CO after oven dry
2extraction obtains composition B.
In a preferred embodiment, above-mentioned facial cream also comprises base material.
In a preferred embodiment, base material contains water, sad, glycerol, cetearyl alcohol, polydimethylsiloxane, silicon wax, the smooth hard acid esters of Pyrusussuriensis, sodium acrylate, 2-Methylpentadecane, Methylisothiazolinone.
In other preferred embodiments, above-mentioned base material can be also the existing conventional cosmetics additive formula that meets cosmetics additive national standard.
Wherein, in the preparation process of mentioned component A, the solid-liquid ratio of water extraction is preferably 1:10; Water bath with thermostatic control is preferably constant temperature 1-3h in 90 ℃ of water-baths.
Wherein, supercritical CO in the preparation process of mentioned component B
2extraction conditions is preferably: extracting pressure 10-20MPa, extraction temperature 30-50 ℃, separating pressure (4.5-6.5) MPa, separation temperature 25-40 ℃, CO
2flow 15-30L*h
-1, extraction time 200-300min.
Two of object of the present invention is also to provide a kind of preparation method of Ganoderma anti-aging face cream.
A preparation method for Ganoderma anti-aging face cream, comprises the following steps:
(1) prepared composition A: the Ganoderma sporophore that is 10-80:10-80:10-80 according to weight portion proportioning, Ganoderma mycelium and Ganoderma spore powder mix after pulverizing, in water bath with thermostatic control, carry out water extraction, solid-liquid ratio is preferably 1:10, preferred constant temperature 1-3h in 90 ℃ of water-baths, concentrate drying obtains composition A;
(2) prepared composition B: the Ganoderma sporophore that is 10-80:10-80:10-80 according to weight portion proportioning, Ganoderma mycelium and Ganoderma spore powder mix, and pulverize supercritical CO after oven dry
2extraction obtains composition B;
(3) prepare facial cream: by A and the emulsifying of B mix homogeneously high temperature, and at high temperature adding base material or cosmetics additive (facial cream additive or skin care product additive) to obtain facial cream, the quality percentage composition that wherein A and B account for facial cream is respectively 0.02%-5% and 0.02%-5%.
In a preferred embodiment, the supercritical CO of above-mentioned steps (2)
2extraction conditions is: extracting pressure 10-20MPa, extraction temperature 30-50 ℃, separating pressure (4.5-6.5) MPa, separation temperature 25-40 ℃, CO
2flow 15-30L*h
-1, extraction time 200-300min.
In Ganoderma sporophore, Ganoderma mycelium and Ganoderma spore, contain the various bioactivators such as polysaccharide, ucleosides, furan derivative, steroid ferment class, alkaloids, protein, polypeptide, amino acids, triterpenes, sesquiterpene, organic germanium, inorganic salt.In addition mycelium has enrichment, can be conducive to absorption of human body by rare element in environment as the inorganic form of selenium, germanium, iodine is converted into organic form, has strengthened Ganoderma mycelium effect.
The present invention has effectively extracted the activity of fighting against senium material in Ganoderma, and active substance is used for making facial cream, experiment confirmation, and prepared facial cream has antidotal effect, and effect is remarkable, and has good safety.
Accompanying drawing explanation
Examples of the present invention will be described by way of reference to the accompanying drawings, wherein:
Fig. 1 is target site skin elasticity variation diagram before and after the Ganoderma anti-aging face cream of embodiment 1 is used.
Fig. 2 is target site skin coarseness variation diagram before and after the Ganoderma anti-aging face cream of embodiment 1 is used.
The specific embodiment
Disclosed all features in this description, or the step in disclosed all methods or process, except mutually exclusive feature and/or step, all can combine by any way.
Disclosed arbitrary feature in this description (comprising any accessory claim, summary and accompanying drawing), unless narration especially all can be replaced by other equivalences or the alternative features with similar object.That is,, unless narration especially, each feature is an example in a series of equivalences or similar characteristics.
Embodiment 1
A preparation method for Ganoderma anti-aging face cream, step is as follows:
1. prepared composition A: Ganoderma sporophore, Ganoderma mycelium and the Ganoderma spore powder of selecting high-quality, mix homogeneously after pulverizing by 30% Ganoderma sporophore, 40% Ganoderma mycelium and 30% Ganoderma spore powder proportioning, then use water extraction, solid-liquid ratio is 1:10, constant temperature 3h in 9O ℃ of water-bath, A is standby for concentrate drying powdered;
2. prepared composition B: select Ganoderma sporophore, Ganoderma mycelium and the Ganoderma spore powder of high-quality, after pulverizing by 30% Ganoderma sporophore, 40% Ganoderma mycelium and 30% Ganoderma spore powder proportioning, mix homogeneously is dried in 65 ℃ of baking ovens, pulverizes, and utilizes supercritical CO
2abstraction technique extraction, extraction conditions is: extracting pressure 15MPa, 35 ℃ of extraction temperature, separating pressure 5.5MPa, 30 ℃ of separation temperatures, CO
2flow 23L? h-1, extraction time 250min, obtains active component B standby;
3. prepare facial cream: by the mass percent that accounts for facial cream by powders A with 0.04% and composition B with 1% mix homogeneously high temperature emulsifying, after emulsifying, high temperature adds base material to obtain Ganoderma anti-aging face cream, optionally can lower the temperature at once, then subpackage, base material is water, sad, glycerol, cetearyl alcohol, polydimethylsiloxane, silicon wax, the smooth hard acid esters of Pyrusussuriensis, sodium acrylate, 2-Methylpentadecane, Methylisothiazolinone, these compositions all meet the national standard about cosmetics additive.
Embodiment 2
A preparation method for Ganoderma anti-aging face cream, step is as follows:
1. prepared composition A: Ganoderma sporophore, Ganoderma mycelium and the Ganoderma spore powder of selecting high-quality, by the quality percentage composition of 35%: 35%: 30%, than mix homogeneously after pulverizing, then use water extraction, solid-liquid ratio is 1:10, constant temperature 3h in 9O ℃ of water-bath, A is standby for concentrate drying powdered;
2. prepared composition B: select Ganoderma sporophore, Ganoderma mycelium and the Ganoderma spore powder of high-quality, dry in 65 ℃ of baking ovens than pulverizing mix homogeneously afterwards by the quality percentage composition of 35%: 35%: 30%, pulverize, utilize supercritical CO
2abstraction technique extraction, extraction conditions is: extracting pressure 17MPa, 34 ℃ of extraction temperature, separating pressure 5.4MPa, 32 ℃ of separation temperatures, CO
2flow 25L*h
-1, extraction time 260min, obtains active component B standby;
3. prepare facial cream: by powders A to account for the mass percent of facial cream 0.06% and composition B to account for the quality percentage composition of facial cream 0.5% than the emulsifying of mix homogeneously high temperature, after emulsifying, high temperature adds base material to obtain Ganoderma anti-aging face cream, optionally can lower the temperature, then subpackage at once.
Embodiment 3
1. prepared composition A: Ganoderma sporophore, Ganoderma mycelium and the Ganoderma spore powder of selecting high-quality, by the quality percentage composition of 25%: 30%: 45%, than mix homogeneously after pulverizing, then use water extraction, solid-liquid ratio is 1:10, constant temperature 3h in 90 ℃ of water-baths, A is standby for concentrate drying powdered;
2. prepared composition B: select Ganoderma sporophore, Ganoderma mycelium and the Ganoderma spore powder of high-quality, dry in 65 ℃ of baking ovens than pulverizing mix homogeneously afterwards by the quality percentage composition of 25%: 30%: 45%, pulverize, utilize supercritical CO
2abstraction technique extraction, extraction conditions is: extracting pressure 17MPa, 33 ℃ of extraction temperature, separating pressure 5.4MPa, 34 ℃ of separation temperatures, CO
2flow 25L*h
-1, extraction time 270min, obtains active component B standby.
3. prepare facial cream: to account for facial cream 0.2% and composition B to account for the quality percentage composition of facial cream 0.5% than the emulsifying of mix homogeneously high temperature, after emulsifying, high temperature adds base material to obtain Ganoderma anti-aging face cream, optionally can lower the temperature, then subpackage at once by powders A.
The efficacy detection of the Ganoderma anti-aging face cream of embodiment 4 embodiment 1:
1, detection method:
Detecting sample is 200 people, after sooner or later clean skin of face, gets appropriate facial cream (1-2mg) and is evenly applied in face and skin of neck separately, is massaged into gently completely and absorbs, and within one day, uses twice, uses altogether 12 weeks.
2, testing result:
1) use the improvement situation of front and back skin elasticity:
The 4th week, the 8th week, the 12nd week detection of skin elastic parameter value after use, and average, Fig. 1, as can be seen from Figure 1, after product is used first 4 weeks, coefficient of skin elasticity R2 numerical value has the trend of minimizing before testing, skin elasticity variation, but use after the 4th week at product, skin elasticity is the trend of improving gradually, after the 8th week, skin elasticity is compared obvious improvement (P < 0.05) with before use.The Cutometer MPA580 that adopts German COURAGE+KHAZAKA (CK) company to produce carries out the mensuration of skin elasticity to experimenter's target site, select parameters R 2 index (R2: the ratio of the maximum tension amount of skin springback capacity when having negative pressure during without negative pressure as a comparison, ratio more approaches 1, and skin elasticity is better)
2) use the improvement situation of front and back skin coarseness:
The 4th week, the 8th week, the 12nd week detection of skin roughness parameter after use, and average, obtain Fig. 2, as can be seen from Figure 2, after product is used first 4 weeks, skin coarseness parameters R 3 is obvious ascendant trend (P < 0.05), it is coarse that skin becomes, but started at the 8th week, R3 is and reduces gradually trend, and along with the product increase of service time, using the 12nd week of product, R3 has obvious minimizing (P < 0.05) before using product, and skin coarseness obviously improves, and it is smooth that skin becomes.
First at canthus target site, with silica gel, make pellosil, then the wrinkle of skin measuring instrument SV600 that uses German COURAGE+KHAZAKA (CK) company to produce carries out the analysis of skin coarseness to experimenter's target site pellosil, selection parameters R 3 is wherein (in measuring length range, contour line is equally divided into 5 sections, obtain the highest crest of every section and the vertical dimension between the darkest trough, their meansigma methods is R3, and R3 is less shows that skin is better, and roughness is less)
Test result shows: 1. Ganoderma anti-aging face cream of the present invention all has certain effect at aspects such as improving xerosis cutis degree, elasticity, glossiness, tiny wrinkle, smoothness, after using product certain hour, can make skin of face holistic health degree there is improvement to a certain degree.2. from the result of experimenter's self-appraisal, product all has certain effect improving skin pliability, smoothness, moisture and moisten aspect degree and holistic health degree.
The present invention is not limited to the aforesaid specific embodiment.The present invention expands to any new feature or any new combination disclosing in this manual, and the arbitrary new method disclosing or step or any new combination of process.
Claims (9)
1. a Ganoderma anti-aging face cream, is characterized in that, comprises that to account for facial cream mass percent be the composition A of 0.02%-5% and the composition B of 0.02%-5%,
Wherein, the preparation process of described composition A is: the Ganoderma sporophore that is 10-80:10-80:10-80 according to weight portion proportioning, Ganoderma mycelium and Ganoderma spore powder mix after pulverizing, and carry out water extraction in water bath with thermostatic control, and concentrate drying obtains composition A;
Wherein, the preparation process of described composition B is: the Ganoderma sporophore that is 10-80:10-80:10-80 according to weight portion proportioning, Ganoderma mycelium and Ganoderma spore powder mix, and pulverize supercritical CO after oven dry
2extraction obtains composition B.
2. a kind of Ganoderma anti-aging face cream as claimed in claim 1, is characterized in that, also comprises base material.
3. a kind of Ganoderma anti-aging face cream as claimed in claim 1 or 2, is characterized in that, in the preparation process of described composition A, the solid-liquid ratio of water extraction is 1:10.
4. a kind of Ganoderma anti-aging face cream as claimed in claim 1 or 2, is characterized in that, in the preparation process of described composition A, water bath with thermostatic control is constant temperature 1-3h in 90 ℃ of water-baths.
5. a kind of Ganoderma anti-aging face cream as claimed in claim 1 or 2, is characterized in that supercritical CO in the preparation process of described composition B
2extraction conditions is: extracting pressure 10-20MPa, extraction temperature 30-50 ℃, separating pressure (4.5-6.5) MPa, separation temperature 25-40 ℃, CO
2flow 15-30L*h
-1, extraction time 200-300min.
6. a preparation method for Ganoderma anti-aging face cream, is characterized in that, comprises the following steps:
(1) prepared composition A: the Ganoderma sporophore that is 10-80:10-80:10-80 according to weight portion proportioning, Ganoderma mycelium and Ganoderma spore powder mix, and carry out water extraction in water bath with thermostatic control, and concentrate drying obtains composition A;
(2) prepared composition B: the Ganoderma sporophore that is 10-80:10-80:10-80 according to weight portion proportioning, Ganoderma mycelium and Ganoderma spore powder mix, and pulverize supercritical CO after oven dry
2extraction obtains composition B;
(3) prepare facial cream: by A and the emulsifying of B mix homogeneously high temperature, and at high temperature add base material to obtain facial cream, the quality percentage composition that wherein A and B account for facial cream is respectively 0.02%-5% and 0.02%-5%.
7. the preparation method of a kind of Ganoderma anti-aging face cream as claimed in claim 6, is characterized in that, in described step (1), the solid-liquid ratio of water extraction is 1:10.
8. the preparation method of a kind of Ganoderma anti-aging face cream as claimed in claim 6, is characterized in that, in described step (1), water bath with thermostatic control is constant temperature 1-3h in 90 ℃ of water-baths.
9. the preparation method of a kind of Ganoderma anti-aging face cream as claimed in claim 6, is characterized in that, the supercritical CO of described step (2)
2extraction conditions is: extracting pressure 10-20MPa, extraction temperature 30-50 ℃, separating pressure (4.5-6.5) MPa, separation temperature 25-40 ℃, CO
2flow 15-30L*h
-1, extraction time 200-300min.
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Cited By (6)
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| CN104473860A (en) * | 2014-12-23 | 2015-04-01 | 广东粤微食用菌技术有限公司 | Ganodermalucidumcollagen mask and preparation process thereof |
| CN105411943A (en) * | 2015-12-22 | 2016-03-23 | 青岛博泰美联化工技术有限公司 | Anti-allergy face cream |
| CN107440945A (en) * | 2017-08-25 | 2017-12-08 | 晟源康生物科技有限公司 | The nourishing cream and preparation method of glossy ganoderma mycelium fermentation extract |
| CN108379135A (en) * | 2018-04-24 | 2018-08-10 | 广州环亚化妆品科技有限公司 | The composition and its extraction process of a kind of purple sesame extract and application |
| CN110522662A (en) * | 2019-08-29 | 2019-12-03 | 福州东星生物技术有限公司 | A kind of ganoderma lucidum face cream and preparation method thereof |
| CN112353719A (en) * | 2020-11-02 | 2021-02-12 | 郭光波 | Anti-aging lucid ganoderma face cream and preparation method thereof |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104473860A (en) * | 2014-12-23 | 2015-04-01 | 广东粤微食用菌技术有限公司 | Ganodermalucidumcollagen mask and preparation process thereof |
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| CN107440945A (en) * | 2017-08-25 | 2017-12-08 | 晟源康生物科技有限公司 | The nourishing cream and preparation method of glossy ganoderma mycelium fermentation extract |
| CN108379135A (en) * | 2018-04-24 | 2018-08-10 | 广州环亚化妆品科技有限公司 | The composition and its extraction process of a kind of purple sesame extract and application |
| CN110522662A (en) * | 2019-08-29 | 2019-12-03 | 福州东星生物技术有限公司 | A kind of ganoderma lucidum face cream and preparation method thereof |
| CN112353719A (en) * | 2020-11-02 | 2021-02-12 | 郭光波 | Anti-aging lucid ganoderma face cream and preparation method thereof |
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| CN103989619B (en) | 2016-05-18 |
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