CN110025730A - A kind of Dendrobidium huoshanness lozenge and preparation method thereof - Google Patents
A kind of Dendrobidium huoshanness lozenge and preparation method thereof Download PDFInfo
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Abstract
The present invention discloses a kind of Dendrobidium huoshanness lozenge, it is related to lozenge processing technique field, based in existing Dendrobidium huoshanness lozenge preparation process because raw material are loose, easily there is the problem of tabletting can not form and propose, Dendrobidium huoshanness lozenge, mainly be prepared from the following raw materials in parts by weight: Dendrobidium huoshanness Ultramicro-powder is 1~9 part, and Dendrobii extract is 1~9 part.The present invention also provides the preparation methods of Dendrobidium huoshanness lozenge, comprising the following steps: (1) mixes；(2) it is granulated；(3) dry；(4) whole grain；(5) tabletting.The beneficial effects of the present invention are: the preparation method of Dendrobidium huoshanness lozenge is able to solve Dendrobidium huoshanness Ultramicro-powder powder loosely in the present invention, the technical issues of direct tablet compressing can not form, after Dendrobii extract is added, compressibility is improved significantly, and the Dendrobidium huoshanness prepared is containing sheet hardness height, not cracky, high yield rate.
Description
Technical field
The present invention relates to lozenge processing technique fields, and in particular to a kind of Dendrobidium huoshanness lozenge and preparation method thereof.
Background technique
Dendrobium nobile, the Shennong's Herbal before being recorded in 2300 earliest, sweet taste, in main wound, gas under eliminating impediment, tonifying five zang organs
Consumptive disease, thin thin, Qiang Yin, long term usage thickness stomach.Dendrobium nobile is always the enriching yin good merchantable brand in Chinese traditional herbs, and Chinese medicine is particular about its road
Ground, Zhao Xuemin records in supplementary Amplifications of the Compendium of Materia Medica " has a kind of short cun of shape to be permitted, carefully such as lampwick, color bluish yellow, nozzle when dendrobium nobile is close
It is sweet in flavor, micro- to have sliding saliva, be six mansion An Zhoujizhou Huoshan County out, name Dendrobidium huoshanness is best ".
The eating method of traditional Dendrobidium huoshanness is soaked after having fresh eating, fresh juicing, maple bucket being made, maple bucket is to boil water, enters meals, decocts
Cream, infusing drugs in wine and milling, in above-mentioned eating method, fresh eating belongs to a kind of side for saving Dendrobidium huoshanness nutritional ingredient to the full extent
Method, but limited by season and region.Above-mentioned other eating methods in addition to fresh eating, it is annual edible, but it is prepared
The effect of complex steps, time-consuming, thus the nutrient loss of Dendrobidium huoshanness is serious, reduces Dendrobidium huoshanness.Modern life
Movable joint is played has no excessive energy by eating Dendrobidium huoshanness by decoction, method that is soaked, entering meals fastly.
Currently, Dendrobidium huoshanness product includes maple bucket, particle, medicinal extract, capsule, lozenge etc., existing Dendrobidium huoshanness lozenge system
Because raw material are loose during standby, easily there is the problem of direct tablet compressing can not form.
Summary of the invention
Present invention solves the technical problem that being in existing Dendrobidium huoshanness lozenge preparation process because raw material are loose, easily go out
Existing tabletting can not form.
The present invention adopts the following technical solutions solves above-mentioned technical problem:
The present invention provides a kind of Dendrobidium huoshanness lozenge, is mainly prepared from the following raw materials in parts by weight: Dendrobidium huoshanness ultra micro
Powder is 1~9 part, and Dendrobii extract is 1~9 part.
Preferably, the weight ratio of the Dendrobidium huoshanness Ultramicro-powder and Dendrobii extract is 1:1.
Preferably, the Dendrobidium huoshanness Ultramicro-powder preparation method the following steps are included:
(1) dry: Dendrobidium huoshanness being placed in vacuum freeze drier, vacuum freeze drying is carried out；
(2) it crushes: the dry item of Dendrobidium huoshanness after freeze-drying being put into pulverizer ambient ground into coarse powder, then is placed in low
Low temperature broken wall in temperature vibration cracker for medicine, the cryogenic temperature are -40~-20 DEG C.
Preferably, the operating condition being freeze-dried in the step (1) are as follows: -50 DEG C~-40 DEG C of pre-freeze, 1h~3h is kept,
Pressure 2Pa~3Pa, keeps 10h~20h, 0 DEG C~20 DEG C of parsing-desiccation temperature, keeps 1h~5h by 0 DEG C~20 DEG C of sublimation temperature.
Preferably, the Dendrobii extract preparation method the following steps are included:
(1) grinding filtering: Dendrobidium huoshanness and water are mixed in the ratio of 1:10~40, mistake after ground machine grinding under room temperature
Filter, obtains Dendrobidium huoshanness filtrate；
(2) it is concentrated: Dendrobidium huoshanness filtrate being placed in inspissator and is concentrated, thickening temperature is 50~70 DEG C, vacuum degree
0.06~0.08Mpa, being concentrated into relative density is 1.15~1.20, obtains Dendrobidium huoshanness concentrate；
(3) dry: Dendrobidium huoshanness concentrate obtained being placed in thermostatic drying chamber and is dried；
(4) crush: product, which is placed in low temperature shock cracker for medicine, in step (3) is crushed, and temperature when crushing is-
40 DEG C~-20 DEG C, obtain Dendrobii extract；
(5) it is sieved: smashed Dendrobii extract is sieved.
Preferably, the Dendrobidium huoshanness is by pretreatment, and the pretreatment is gone the following steps are included: select Dendrobidium huoshanness
It except surface impurity, is cleaned with circulating water, removes root, the branches and leaves of Dendrobidium huoshanness, and make dissection processing.
Preferably, the drying temperature in the step (3) is 50~60 DEG C, and drying time is 10~15h.
Preferably, 60~100 meshes are crossed in the step (5).
It preferably, further include 0-2 parts of sweeteners in the Dendrobidium huoshanness lozenge, the sweetener is D-sorbite, malt
One of sugar alcohol or antierythrite.
The present invention also provides a kind of preparation methods of Dendrobidium huoshanness lozenge, comprising the following steps:
(1) it mixes: Dendrobidium huoshanness Ultramicro-powder, Dendrobii extract is uniformly mixed in proportion, it is mixed to obtain Dendrobidium huoshanness
Close object；
(2) it is granulated: dehydrated alcohol wetting being added into Dendrobidium huoshanness mixture, after evenly mixing, is granulated with pelletizer, and
Sieving processing, is made Dendrobidium huoshanness tablet；
(3) dry: the Dendrobidium huoshanness tablet after granulation is dry with thermostatic drying chamber；
(4) whole grain: the Dendrobidium huoshanness tablet after drying is sieved, and screens out incomplete Dendrobidium huoshanness tablet；
(5) tabletting: complete Dendrobidium huoshanness tablet is subjected to tabletting with tablet press machine, adjusts slice weight.
Preferably, the Dendrobidium huoshanness Ultramicro-powder preparation method the following steps are included:
(1) dry: Dendrobidium huoshanness being placed in vacuum freeze drier, vacuum freeze drying is carried out；
(2) it crushes: the dry item of Dendrobidium huoshanness after freeze-drying being put into pulverizer ambient ground into coarse powder, then is placed in low
Low temperature broken wall in temperature vibration cracker for medicine, the cryogenic temperature are -40~-20 DEG C.
Preferably, the operating condition being freeze-dried in the step (1) are as follows: -50 DEG C~-40 DEG C of pre-freeze, 1h~3h is kept,
Pressure 2Pa~3Pa, keeps 10h~20h, 0 DEG C~20 DEG C of parsing-desiccation temperature, keeps 1h~5h by 0 DEG C~20 DEG C of sublimation temperature.
Preferably, the Dendrobii extract preparation method the following steps are included:
(1) grinding filtering: Dendrobidium huoshanness and water are mixed in the ratio of 1:10~40, mistake after ground machine grinding under room temperature
Filter, obtains Dendrobidium huoshanness filtrate；
(2) it is concentrated: Dendrobidium huoshanness filtrate being placed in inspissator and is concentrated, thickening temperature is 50~70 DEG C, vacuum degree
0.06~0.08Mpa, being concentrated into relative density is 1.15~1.20, obtains Dendrobidium huoshanness concentrate；
(3) dry: Dendrobidium huoshanness concentrate obtained being placed in thermostatic drying chamber and is dried；
(4) crush: product, which is placed in low temperature shock cracker for medicine, in step (3) is crushed, and temperature when crushing is-
40 DEG C~-20 DEG C, obtain Dendrobii extract；
(5) it is sieved: smashed Dendrobii extract is sieved.
Preferably, the Dendrobidium huoshanness is by pretreatment, and the pretreatment is gone the following steps are included: select Dendrobidium huoshanness
It except surface impurity, is cleaned with circulating water, removes root, the branches and leaves of Dendrobidium huoshanness, and make dissection processing.
Preferably, the drying temperature in the step (3) is 50~60 DEG C, and drying time is 10~15h.
Preferably, 60~100 meshes are crossed in the step (5).
It preferably, further include 0-2 parts of sweeteners in the Dendrobidium huoshanness lozenge, the sweetener is D-sorbite, malt
One of sugar alcohol or antierythrite.
The beneficial effects of the present invention are:
(1) Dendrobidium huoshanness lozenge mouthfeel prepared by the present invention is satiny, can retain the original flavour of medicinal material, and without bonding
Agent can retain the nutritional ingredient of Dendrobidium huoshanness, promote the utility value of Dendrobidium huoshanness, and then meet consumer demand；And
Dendrobidium huoshanness obtained is containing sheet hardness height, not cracky, high yield rate；
(2) preparation method of Dendrobidium huoshanness lozenge is able to solve Dendrobidium huoshanness Ultramicro-powder powder loosely in the present invention, directly
The technical issues of tabletting can not form is connect, after Dendrobii extract is added, compressibility is improved significantly.
Detailed description of the invention
Fig. 1 is the flow chart of Dendrobidium huoshanness process for preparing buccal lozenge in the present invention；
In figure: being D grades of clean areas in dotted line frame, the neatness standard of clean area presses " health food Good Manufacture Practice "
(GMP) standard executes；It is general production district outside dotted line frame.
Specific embodiment
The present invention is described in further details below with reference to Figure of description and embodiment.
Test material and reagent as used in the following examples etc., unless otherwise specified, commercially obtain.
In the examples where no specific technique or condition is specified, can according to the literature in the art described technology or
Condition is carried out according to product description.
Fig. 1 is the flow chart of the preparation method of Dendrobidium huoshanness lozenge provided by the invention；
Dendrobidium huoshanness lozenge provided by the invention, including Dendrobidium huoshanness Ultramicro-powder and Dendrobii extract, by weight,
Dendrobidium huoshanness Ultramicro-powder is 1~9 part, and Dendrobii extract is 1~9 part.
Dendrobidium huoshanness lozenge provided by the invention is able to solve Dendrobidium huoshanness Ultramicro-powder powder loosely, and direct tablet compressing can not
The technical issues of molding, after Dendrobii extract is added, compressibility is significantly promoted, and Dendrobidium huoshanness obtained contains sheet hardness
Height, not cracky, high yield rate, the Dendrobidium huoshanness lozenge mouthfeel in the present invention is satiny, remains the original flavour of medicinal material, and be free of
Binder remains the nutritional ingredient of Dendrobidium huoshanness to the full extent, improves the utility value of Dendrobidium huoshanness, to the full extent
Meet consumer demand.
In a preferred embodiment, the weight ratio of Dendrobidium huoshanness Ultramicro-powder and Dendrobii extract is 1:1.Suddenly
When the Herba Dendrobii extract accounting 50% of mountain, mouldability is best, and Dendrobidium huoshanness obtained is high (up to 6~10kgf (thousand containing sheet hardness
Gram force)), not cracky, high yield rate.
Dendrobidium huoshanness Ultramicro-powder is prepared in accordance with the following steps:
(1) pre-process: selecting Dendrobidium huoshanness, remove surface impurity, cleaned with circulating water, remove Dendrobidium huoshanness root,
Branches and leaves, and make dissection processing；
(2) dry: the pretreated brown Dendrobidium huoshanness of institute is placed in vacuum freeze drier, carries out vacuum freeze drying；
Carrying out vacuum freeze drying concrete operations is -50 DEG C~-40 DEG C of pre-freeze, keeps 1h~3h, pressure 2Pa~3Pa, sublimation temperature 0
DEG C~20 DEG C, 10h~20h is kept, 0 DEG C~20 DEG C of parsing-desiccation temperature, keeps 1h~5h.
(3) crush: the dry item of Dendrobidium huoshanness after freeze-drying is put into pulverizer ambient ground into coarse powder, then is placed in low temperature
Low temperature broken wall in cracker for medicine is vibrated, operating temperature is -40 DEG C~-20 DEG C.
Dendrobidium huoshanness Ultramicro-powder is that through vacuum freeze drying, crushing, low temperature broken wall superfine powder is made in the fresh item of Dendrobidium huoshanness.Suddenly
Mountain dendrobium nobile maintains the activity of Dendrobidium huoshanness effective component after vacuum freeze drying, reduces oxidation；It is broken through pulverizer low temperature again
Wall is avoided when normal temperature condition carries out pulverizing process, and the high temperature of generation causes the stream of effective component in Dendrobidium huoshanness freeze-drying item
The destruction for bioactivity of becoming estranged, the loss of flavor substance, appearance luster variation, so that the medical value of dendrobium nobile is unable to fully benefit
With, and wall breaking technology is used, Dendrobidium huoshanness effective component can be made sufficiently to discharge, cell-wall breaking ratio is high, improves effective component
Dissolution, drug action enhancing, utilization rate is high.
Dendrobii extract is prepared in accordance with the following steps:
(1) pre-process: selecting Dendrobidium huoshanness, remove surface impurity, cleaned with circulating water, remove Dendrobidium huoshanness root,
Branches and leaves；
(2) grinding filtering: pretreated Dendrobidium huoshanness and tap water are mixed in the ratio of 1:10~40, through grinding under room temperature
It is filtered after grinding machine grinding, obtains Dendrobidium huoshanness filtrate；
(3) it is concentrated: Dendrobidium huoshanness filtrate being placed in inspissator and is concentrated, thickening temperature is 50~70 DEG C, vacuum degree
0.06~0.08Mpa, until relative density 1.15~1.20, obtains Dendrobidium huoshanness concentrate；
(4) dry: Dendrobidium huoshanness concentrate being placed in thermostatic drying chamber and is dried, 50~60 DEG C, 10~15h is obtained
Dendrobidium huoshanness concentrate；
(5) it crushes: Dendrobidium huoshanness concentrate being placed in low temperature shock cracker for medicine and is crushed, operating temperature -40
DEG C~-20 DEG C, obtain Dendrobii extract；
(6) it is sieved: Dendrobii extract is sieved, sieve mesh number is 60~100 mesh.
Dendrobii extract be ground Dendrobidium huoshanness, filtering, concentration, it is dry, crush extract powder be made；Wherein adopt
The mode ground with room temperature, Dendrobidium huoshanness contain polysaccharide, alkaloid, amino acid, luxuriant and rich with fragrance class, phenols, flavonoids and vitamins
Etc. multiple nutritional components, these effective components focus primarily upon into the cell, fresh Dendrobidium huoshanness cell is easily broken, and the grinding of this technique is thin
Degree is up to 2 μm, and cell dia can break cell wall at 50 μm or so completely, discharges nutritional ingredient therein.And it ought be suddenly
Mountain dendrobium nobile is after being dried, cell dehydration, and conventional extracting method is difficult to propose nutritional ingredient；Concentrated, dry again,
Low temperature broken wall farthest retains the nutritional ingredient and bioactivity of Dendrobidium huoshanness in whole process, reduce because plus
The loss that work generates.Therefore the nutritional ingredients yield such as polysaccharide of ultra micro extraction process proposition and the rate of transform are high, and decoct relative to conventional
The high temperature extracting mode boiled, Dendrobidium huoshanness polysaccharide yield are higher by 50%, and remain script flavour.
It in a preferred embodiment, further include sweetener, sweetener is D-sorbite, maltitol or erythrose
One of alcohol, sweetener are 0~2 part by weight.Sweetener can also be added in Dendrobidium huoshanness lozenge provided by the invention,
While guaranteeing product quality, cost can be suitably reduced, promotes lozenge mouthfeel.
The preparation method of Dendrobidium huoshanness lozenge provided by the invention, comprising the following steps:
(1) it mixes: Dendrobidium huoshanness Ultramicro-powder, Dendrobii extract is uniformly mixed in proportion, it is mixed to obtain Dendrobidium huoshanness
Close object；
(2) it is granulated: dehydrated alcohol wetting being added into Dendrobidium huoshanness mixture, after evenly mixing, is granulated with pelletizer, and
Sieving processing, is made Dendrobidium huoshanness tablet；
(3) dry: the Dendrobidium huoshanness tablet after granulation is dry with thermostatic drying chamber；
(4) whole grain: the Dendrobidium huoshanness tablet after drying is sieved, and screens out incomplete Dendrobidium huoshanness tablet；
(5) tabletting: complete Dendrobidium huoshanness tablet is subjected to tabletting with tablet press machine, adjusts slice weight.
Embodiment 1
(1) preparation of Dendrobidium huoshanness Ultramicro-powder
(1) pre-process: selecting Dendrobidium huoshanness, remove surface impurity, cleaned with circulating water, remove Dendrobidium huoshanness root,
Branches and leaves, and make dissection processing；
(2) dry: pretreated Dendrobidium huoshanness is placed in vacuum freeze drier, and vacuum freeze drying condition is pre-
Freeze -50 DEG C, keeps 1h, pressure 2Pa, 0 DEG C of sublimation temperature, keep 10h, 0 DEG C of parsing-desiccation temperature, keep 1h；
(3) crush: the dry item of Dendrobidium huoshanness after freeze-drying is put into Universalpulverizer ambient ground into coarse powder, then is placed in
Low temperature broken wall in low temperature shock cracker for medicine, -40 DEG C of operating temperature；
(2) preparation of Dendrobii extract
(1) pre-process: selecting Dendrobidium huoshanness, remove surface impurity, cleaned with circulating water, remove Dendrobidium huoshanness root,
Branches and leaves；
(2) grinding filtering: pretreated Dendrobidium huoshanness and tap water are mixed in the ratio of 1:10, after ground machine grinding
Filtering, obtains Dendrobidium huoshanness filtrate；
(3) be concentrated: Dendrobidium huoshanness filtrate, which is placed in single-effect concentrator, to be concentrated, and thickening temperature is 50 DEG C, vacuum degree
0.06Mpa, until relative density 1.15, obtains Dendrobidium huoshanness concentrate；
(4) dry: Dendrobidium huoshanness concentrate being placed in thermostatic drying chamber and is dried, drying temperature is 50 DEG C, dry
Time is 10h；
(5) crush: Dendrobidium huoshanness concentrate is placed in low temperature shock cracker for medicine and is crushed, and operating temperature is -40
DEG C, obtain Dendrobii extract；
(6) it is sieved: Dendrobii extract sieving is handled, sieve mesh number is 60 mesh.
(3) preparation of Dendrobidium huoshanness lozenge
(1) it mixes: 6 parts of Dendrobidium huoshanness Ultramicro-powders, 4 parts of Dendrobii extracts uniformly being mixed in proportion, obtain Huoshan
Dendrobium nobile mixture；
(2) it is granulated: dehydrated alcohol wetting being added into Dendrobidium huoshanness mixture, after evenly mixing, is made with pelletizer
Grain, and processing of being sieved；
(3) dry: the Dendrobidium huoshanness tablet after granulation is placed in drying in thermostatic drying chamber, and 55 DEG C of drying temperature, drying is extremely
Dendrobidium huoshanness tablet moisture content is 3%；Wherein the measuring method of moisture content is the prior art；
(4) whole grain: the Dendrobidium huoshanness tablet sieving processing after dry screens out incomplete Dendrobidium huoshanness tablet；
(5) tabletting: complete Dendrobidium huoshanness tablet carries out compressing tablet process with tablet press machine, adjusts per a piece of Dendrobidium huoshanness lozenge
Slice weight.
As shown in Figure 1, to reduce influence and guarantee product matter of the microorganism to product in Dendrobidium huoshanness lozenge preparation process
Amount, part preparation process, the preparation process of Dendrobii extract of Dendrobidium huoshanness Ultramicro-powder are completed in D grades of clean areas,
The neatness standard of clean area is executed by " health food Good Manufacture Practice " (GMP) standard.
Embodiment 2
(1) preparation of Dendrobidium huoshanness Ultramicro-powder
(1) pre-process: selecting Dendrobidium huoshanness, remove surface impurity, cleaned with circulating water, remove Dendrobidium huoshanness root,
Branches and leaves, and make dissection processing；
(2) dry: pretreated Dendrobidium huoshanness is placed in vacuum freeze drier, and vacuum freeze drying condition is pre-
Freeze -48 DEG C, keeps 1h, pressure 2Pa, 5 DEG C of sublimation temperature, keep 12h, 5 DEG C of parsing-desiccation temperature, keep 2h；
(3) crush: the dry item of Dendrobidium huoshanness after freeze-drying is put into Universalpulverizer ambient ground into coarse powder, then is placed in
Low temperature broken wall in low temperature shock cracker for medicine, operating temperature are -35 DEG C；
(2) preparation of Dendrobii extract
(1) pre-process: selecting Dendrobidium huoshanness, remove surface impurity, cleaned with circulating water, remove Dendrobidium huoshanness root,
Branches and leaves；
(2) grinding filtering: pretreated Dendrobidium huoshanness and tap water are mixed in the ratio of 1:20, after ground machine grinding
Filtering, obtains Dendrobidium huoshanness filtrate；
(3) be concentrated: Dendrobidium huoshanness filtrate, which is placed in single-effect concentrator, to be concentrated, and thickening temperature is 55 DEG C, vacuum degree
0.06Mpa, until relative density 1.16, obtains Dendrobidium huoshanness concentrate；
(4) dry: Dendrobidium huoshanness concentrate being placed in thermostatic drying chamber and is dried, drying temperature is 54 DEG C, dry
Time is 12h；
(5) crush: Dendrobidium huoshanness concentrate is placed in low temperature shock cracker for medicine and is crushed, and operating temperature is -35
DEG C, obtain Dendrobii extract；
(6) it is sieved: Dendrobii extract sieving is handled, sieve mesh number is 60 mesh.
(3) preparation of Dendrobidium huoshanness lozenge
(1) it mixes: 6 parts of Dendrobidium huoshanness Ultramicro-powders, 4 parts of Dendrobii extracts uniformly being mixed in proportion, obtain Huoshan
Dendrobium nobile mixture；
(2) it is granulated: dehydrated alcohol wetting being added into Dendrobidium huoshanness mixture, after evenly mixing, is made with pelletizer
Grain, and processing of being sieved；
(3) dry: the Dendrobidium huoshanness tablet after granulation is placed in drying in thermostatic drying chamber, and drying temperature is 55 DEG C, dry
It is 3% to Dendrobidium huoshanness tablet moisture content；Wherein the measuring method of moisture content is the prior art；
(4) whole grain: the Dendrobidium huoshanness tablet sieving processing after dry screens out incomplete Dendrobidium huoshanness tablet；
(5) tabletting: complete Dendrobidium huoshanness tablet carries out compressing tablet process with tablet press machine, adjusts per a piece of Dendrobidium huoshanness lozenge
Slice weight.
Embodiment 3
(1) preparation of Dendrobidium huoshanness Ultramicro-powder
(1) pre-process: selecting Dendrobidium huoshanness, remove surface impurity, cleaned with circulating water, remove Dendrobidium huoshanness root,
Branches and leaves, and make dissection processing；
(2) dry: pretreated Dendrobidium huoshanness is placed in vacuum freeze drier, -45 DEG C of pre-freeze, keeps 2h, pressure
2Pa, keeps 15h, 10 DEG C of parsing-desiccation temperature, keeps 3h by 10 DEG C of sublimation temperature；
(3) crush: the dry item of Dendrobidium huoshanness after freeze-drying is put into Universalpulverizer ambient ground into coarse powder, then is placed in
Low temperature broken wall in low temperature shock cracker for medicine, -30 DEG C of operating temperature；
(2) preparation of Dendrobii extract
(1) pre-process: selecting Dendrobidium huoshanness, remove surface impurity, cleaned with circulating water, remove Dendrobidium huoshanness root,
Branches and leaves；
(2) grinding filtering: pretreated Dendrobidium huoshanness and tap water are mixed in the ratio of 1:25, after ground machine grinding
Filtering, obtains Dendrobidium huoshanness filtrate；
(3) be concentrated: Dendrobidium huoshanness filtrate, which is placed in single-effect concentrator, to be concentrated, and thickening temperature is 60 DEG C, vacuum degree
0.07Mpa, until relative density 1.18, obtains Dendrobidium huoshanness concentrate；
(4) dry: Dendrobidium huoshanness concentrate being placed in thermostatic drying chamber and is dried, drying temperature is 55 DEG C, dry
Time is 14h；
(5) crush: Dendrobidium huoshanness concentrate is placed in low temperature shock cracker for medicine and is crushed, and operating temperature is -30
DEG C, obtain Dendrobii extract；
(6) it is sieved: Dendrobii extract sieving is handled, sieve mesh number is 80 mesh.
(3) preparation of Dendrobidium huoshanness lozenge
(1) it mixes: 9 parts of Dendrobidium huoshanness Ultramicro-powders, 7 parts of Dendrobii extracts uniformly being mixed in proportion, obtain Huoshan
Dendrobium nobile mixture；
(2) it is granulated: dehydrated alcohol wetting being added into Dendrobidium huoshanness mixture, after evenly mixing, is made with pelletizer
Grain, and processing of being sieved；
(3) dry: the Dendrobidium huoshanness tablet after granulation is placed in drying in thermostatic drying chamber, and drying temperature is 58 DEG C, dry
It is 5% to Dendrobidium huoshanness tablet moisture content；Wherein the measuring method of moisture content is the prior art；
(4) whole grain: the Dendrobidium huoshanness tablet sieving processing after dry screens out incomplete Dendrobidium huoshanness tablet；
(5) tabletting: complete Dendrobidium huoshanness tablet carries out compressing tablet process with tablet press machine, adjusts per a piece of Dendrobidium huoshanness lozenge
Slice weight.
Embodiment 4
(1) preparation of Dendrobidium huoshanness Ultramicro-powder
(1) pre-process: selecting Dendrobidium huoshanness, remove surface impurity, cleaned with circulating water, remove Dendrobidium huoshanness root,
Branches and leaves, and make dissection processing；
(2) dry: pretreated Dendrobidium huoshanness is placed in vacuum freeze drier, and vacuum freeze drying condition is pre-
Freeze -42 DEG C, keeps 3h, pressure 3Pa, 15 DEG C of sublimation temperature, keep 18h, 14 DEG C of parsing-desiccation temperature, keep 4h；
(3) crush: the dry item of Dendrobidium huoshanness after freeze-drying is put into Universalpulverizer ambient ground into coarse powder, then is placed in
Low temperature broken wall in low temperature shock cracker for medicine, operating temperature are -25 DEG C；
(2) preparation of Dendrobii extract
(1) pre-process: selecting Dendrobidium huoshanness, remove surface impurity, cleaned with circulating water, remove Dendrobidium huoshanness root,
Branches and leaves；
(2) grinding filtering: pretreated Dendrobidium huoshanness and tap water are mixed in the ratio of 1:30, after ground machine grinding
Filtering, obtains Dendrobidium huoshanness filtrate；
(3) be concentrated: Dendrobidium huoshanness filtrate, which is placed in single-effect concentrator, to be concentrated, and thickening temperature is 65 DEG C, vacuum degree
0.07Mpa, until relative density 1.20, obtains Dendrobidium huoshanness concentrate；
(4) dry: Dendrobidium huoshanness concentrate being placed in thermostatic drying chamber and is dried, drying temperature is 58 DEG C, dry
Time is 15h；
(5) crush: Dendrobidium huoshanness concentrate is placed in low temperature shock cracker for medicine and is crushed, and -25 DEG C of operating temperature,
Obtain Dendrobii extract；
(6) it is sieved: Dendrobii extract sieving is handled, sieve mesh number is 80 mesh.
(3) preparation of Dendrobidium huoshanness lozenge
(1) it mixes: 4 parts of Dendrobidium huoshanness Ultramicro-powders, 7 parts of Dendrobii extracts uniformly being mixed in proportion, obtain Huoshan
Dendrobium nobile mixture；
(2) it is granulated: dehydrated alcohol wetting being added into Dendrobidium huoshanness mixture, after evenly mixing, is made with pelletizer
Grain, and processing of being sieved；
(3) dry: the Dendrobidium huoshanness tablet after granulation is placed in drying in thermostatic drying chamber, and drying temperature is 58 DEG C, dry
It is 5% to Dendrobidium huoshanness tablet moisture content；
(4) whole grain: the Dendrobidium huoshanness tablet sieving processing after dry screens out incomplete Dendrobidium huoshanness tablet；
(5) tabletting: complete Dendrobidium huoshanness tablet carries out compressing tablet process with tablet press machine, adjusts per a piece of Dendrobidium huoshanness lozenge
Slice weight.
Embodiment 5
(1) preparation of Dendrobidium huoshanness Ultramicro-powder
(1) pre-process: selecting Dendrobidium huoshanness, remove surface impurity, cleaned with circulating water, remove Dendrobidium huoshanness root,
Branches and leaves, and make dissection processing；
(2) dry: pretreated Dendrobidium huoshanness is placed in vacuum freeze drier, and vacuum freeze drying condition is pre-
Freeze -40 DEG C, keeps 3h, pressure 3Pa, 20 DEG C of sublimation temperature, keep 20h, 20 DEG C of parsing-desiccation temperature, keep 5h；
(3) crush: the dry item of Dendrobidium huoshanness after freeze-drying is put into Universalpulverizer ambient ground into coarse powder, then is placed in
Low temperature broken wall in low temperature shock cracker for medicine, operating temperature are -20 DEG C；
(2) preparation of Dendrobii extract
(1) pre-process: selecting Dendrobidium huoshanness, remove surface impurity, cleaned with circulating water, remove Dendrobidium huoshanness root,
Branches and leaves；
(2) grinding filtering: pretreated Dendrobidium huoshanness and tap water are mixed in the ratio of 1:40, after ground machine grinding
Filtering, obtains Dendrobidium huoshanness filtrate；
(3) be concentrated: Dendrobidium huoshanness filtrate, which is placed in single-effect concentrator, to be concentrated, and thickening temperature is 70 DEG C, vacuum degree
0.08Mpa, until relative density 1.20, obtains Dendrobidium huoshanness concentrate；
(4) dry: Dendrobidium huoshanness concentrate being placed in thermostatic drying chamber and is dried, drying temperature is 60 DEG C, dry
Time is 15h；
(5) crush: Dendrobidium huoshanness concentrate is placed in low temperature shock cracker for medicine and is crushed, and operating temperature is -20
DEG C, obtain Dendrobii extract；
(6) it is sieved: Dendrobii extract sieving is handled, sieve mesh number is 100 mesh.
(3) preparation of Dendrobidium huoshanness lozenge
(1) it mixes: 8 parts of Dendrobidium huoshanness Ultramicro-powders, 9 parts of Dendrobii extracts uniformly being mixed in proportion, obtain Huoshan
Dendrobium nobile mixture；
(2) it is granulated: dehydrated alcohol wetting being added into Dendrobidium huoshanness mixture, after evenly mixing, is made with pelletizer
Grain, and processing of being sieved；
(3) dry: the Dendrobidium huoshanness tablet after granulation is placed in drying in thermostatic drying chamber, and drying temperature is 60 DEG C, dry
It is 8% to Dendrobidium huoshanness tablet moisture content；Wherein determination of moisture method is the prior art；
(4) whole grain: the Dendrobidium huoshanness tablet sieving processing after dry screens out incomplete Dendrobidium huoshanness tablet；
(5) tabletting: complete Dendrobidium huoshanness tablet carries out compressing tablet process with tablet press machine, adjusts per a piece of Dendrobidium huoshanness lozenge
Slice weight.
Embodiment 6
The present embodiment the difference from embodiment 1 is that, 9 parts of Dendrobidium huoshanness Ultramicro-powder, 1 part of Dendrobii extract.
Embodiment 7
The present embodiment the difference from embodiment 1 is that, 8 parts of Dendrobidium huoshanness Ultramicro-powder, 2 parts of Dendrobii extract.
Embodiment 8
The present embodiment the difference from embodiment 1 is that, 7 parts of Dendrobidium huoshanness Ultramicro-powder, 3 parts of Dendrobii extract.
Embodiment 9
The present embodiment the difference from embodiment 1 is that, 5 parts of Dendrobidium huoshanness Ultramicro-powder, 5 parts of Dendrobii extract.
Embodiment 10
The present embodiment the difference from embodiment 1 is that, 3 parts of Dendrobidium huoshanness Ultramicro-powder, 7 parts of Dendrobii extract.
Embodiment 11
The present embodiment the difference from embodiment 1 is that, 2 parts of Dendrobidium huoshanness Ultramicro-powder, 8 parts of Dendrobii extract.
Embodiment 12
The present embodiment the difference from embodiment 1 is that, 1 part of Dendrobidium huoshanness Ultramicro-powder, 9 parts of Dendrobii extract.
Embodiment 13
The present embodiment the difference from embodiment 1 is that, further include sweetener, sweetener is D-sorbite, maltitol, red
One of moss sugar alcohol, stevioside.2 parts by weight of sweetener, sweetener and Dendrobidium huoshanness Ultramicro-powder, Dendrobidium huoshanness extract
Object is taken to mix.
Embodiment 14
The Dendrobidium huoshanness lozenge prepared in embodiment 6-12 is measured, measurement item include Determination of Hardness and tablet at
Type state, wherein Determination of Hardness is measured using tablet hardness instrument, and experimental result is as shown in table 1.
1 Dendrobidium huoshanness of table contains sheet hardness and tablet sense organ measurement result
As can be seen from Table 1, obtained when the weight ratio of Dendrobidium huoshanness Ultramicro-powder and Dendrobii extract is 1:1
Dendrobidium huoshanness lozenge surface consolidation, glossy, without viscous without formed punch, tablet hardness is higher.
The present invention changes the edible way of Dendrobidium huoshanness.Traditional Dendrobidium huoshanness is with the shape of fresh item, maple bucket, dry item, powdery
Formula exists, or juicing or soaked or Baoshang or other Chinese herbal medicines of compatibility are eaten, and the present invention directly saves Dendrobidium huoshanness itself
Flavour, it is tabletted, it is convenient.The present invention uses superfine grinding and low temperature wall breaking technology, and improving Dendrobidium huoshanness has
The dissolution for imitating the nutriments such as ingredient polysaccharide, polyphenol, alkaloid, retains nutritional ingredient to the full extent.Dendrobidium huoshanness lozenge at
Type is good, and hardness is high, not cracky, high yield rate.
The above is only the preferred embodiment of the present invention, protection scope of the present invention is not limited merely to above-described embodiment,
It is within the scope of the invention with present inventive concept without the various process programs of substantial differences.
Claims (10)
1. a kind of Dendrobidium huoshanness lozenge, it is characterised in that: the Dendrobidium huoshanness lozenge is mainly by the raw material system of following parts by weight
At: Dendrobidium huoshanness Ultramicro-powder is 1~9 part, and Dendrobii extract is 1~9 part.
2. Dendrobidium huoshanness lozenge according to claim 1, it is characterised in that: the Dendrobidium huoshanness Ultramicro-powder and Dendrobidium huoshanness
The weight ratio of extract is 1:1.
3. Dendrobidium huoshanness lozenge according to claim 1, it is characterised in that: the preparation method of the Dendrobidium huoshanness Ultramicro-powder
The following steps are included:
(1) dry: Dendrobidium huoshanness being placed in vacuum freeze drier, vacuum freeze drying is carried out；
(2) it crushes: the dry item of Dendrobidium huoshanness after freeze-drying is put into pulverizer ambient ground into coarse powder, then be placed in low temperature vibration
Low temperature broken wall in dynamic cracker for medicine, the cryogenic temperature are -40~-20 DEG C.
4. Dendrobidium huoshanness lozenge according to claim 3, it is characterised in that: the operation being freeze-dried in the step (1)
Condition are as follows: -50 DEG C~-40 DEG C of pre-freeze, keep 1h~3h, pressure 2Pa~3Pa, 0 DEG C~20 DEG C of sublimation temperature, keep 10h~
20h, keeps 1h~5h by 0 DEG C~20 DEG C of parsing-desiccation temperature.
5. Dendrobidium huoshanness lozenge according to claim 1, it is characterised in that: the preparation method of the Dendrobii extract
The following steps are included:
(1) grinding filtering: Dendrobidium huoshanness and water being mixed in the ratio of 1:10~40, filtered after ground machine grinding under room temperature,
Obtain Dendrobidium huoshanness filtrate；
(2) it is concentrated: Dendrobidium huoshanness filtrate being placed in inspissator and is concentrated, thickening temperature is 50~70 DEG C, vacuum degree 0.06
~0.08Mpa, being concentrated into relative density is 1.15~1.20, obtains Dendrobidium huoshanness concentrate；
(3) dry: Dendrobidium huoshanness concentrate obtained being placed in thermostatic drying chamber and is dried；
(4) crush: product, which is placed in low temperature shock cracker for medicine, in step (3) is crushed, and temperature when crushing is -40 DEG C
~-20 DEG C, obtain Dendrobii extract；
(5) it is sieved: smashed Dendrobii extract is sieved.
6. the Dendrobidium huoshanness lozenge according to claim 3 or 5, it is characterised in that: the Dendrobidium huoshanness is by pretreatment, institute
Pretreatment is stated the following steps are included: selecting Dendrobidium huoshanness, surface impurity is removed, is cleaned with circulating water, remove the root of Dendrobidium huoshanness
Palpus, branches and leaves, and make dissection processing.
7. preparing the preparation method of Dendrobidium huoshanness lozenge described in claim 1, it is characterised in that: the following steps are included:
(1) it mixes: Dendrobidium huoshanness Ultramicro-powder, Dendrobii extract uniformly being mixed in proportion, obtain Dendrobidium huoshanness mixture；
(2) it is granulated: dehydrated alcohol wetting being added into Dendrobidium huoshanness mixture, after evenly mixing, is granulated with pelletizer, and be sieved
Dendrobidium huoshanness tablet is made in processing；
(3) dry: the Dendrobidium huoshanness tablet after granulation is dry with thermostatic drying chamber；
(4) whole grain: the Dendrobidium huoshanness tablet after drying is sieved, and screens out incomplete Dendrobidium huoshanness tablet；
(5) tabletting: complete Dendrobidium huoshanness tablet is subjected to tabletting with tablet press machine, adjusts slice weight.
8. the preparation method of Dendrobidium huoshanness lozenge according to claim 7, it is characterised in that: the Dendrobidium huoshanness Ultramicro-powder
Preparation method the following steps are included:
(1) dry: Dendrobidium huoshanness being placed in vacuum freeze drier, vacuum freeze drying is carried out；
(2) it crushes: the dry item of Dendrobidium huoshanness after freeze-drying is put into pulverizer ambient ground into coarse powder, then be placed in low temperature vibration
Low temperature broken wall in dynamic cracker for medicine, the cryogenic temperature are -40~-20 DEG C.
9. the preparation method of Dendrobidium huoshanness lozenge according to claim 7, it is characterised in that: freezing in the step (1)
Dry operating condition are as follows: -50 DEG C~-40 DEG C of pre-freeze, keep 1h~3h, pressure 2Pa~3Pa, 0 DEG C~20 DEG C of sublimation temperature,
10h~20h is kept, 0 DEG C~20 DEG C of parsing-desiccation temperature, keeps 1h~5h.
10. the preparation method of the Dendrobii extract the following steps are included:
(1) grinding filtering: Dendrobidium huoshanness and water being mixed in the ratio of 1:10~40, filtered after ground machine grinding under room temperature,
Obtain Dendrobidium huoshanness filtrate；
(2) it is concentrated: Dendrobidium huoshanness filtrate being placed in inspissator and is concentrated, thickening temperature is 50~70 DEG C, vacuum degree 0.06
~0.08Mpa, being concentrated into relative density is 1.15~1.20, obtains Dendrobidium huoshanness concentrate；
(3) dry: Dendrobidium huoshanness concentrate obtained being placed in thermostatic drying chamber and is dried；
(4) crush: product, which is placed in low temperature shock cracker for medicine, in step (3) is crushed, and temperature when crushing is -40 DEG C
~-20 DEG C, obtain Dendrobii extract；
(5) it is sieved: smashed Dendrobii extract is sieved.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112206282A (en) * | 2020-10-13 | 2021-01-12 | 安徽霍山县药王谷林农科技有限公司 | Pure dendrobium huoshanense ultramicro wall-broken buccal tablet |
| CN113172925A (en) * | 2021-05-17 | 2021-07-27 | 霍山县天下泽雨生物科技发展有限公司 | Preparation method of compound dendrobium huoshanense buccal tablets |
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| CN102302680A (en) * | 2011-09-16 | 2012-01-04 | 蔡光先 | Processing method capable of reserving all components of dendrobium officinale |
| CN104958567A (en) * | 2015-08-04 | 2015-10-07 | 桂林伯林生物技术有限公司 | Dendrobium candidum wall.ex lindl lozenge and preparation method thereof |
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| CN1457808A (en) * | 2002-05-14 | 2003-11-26 | 上海市中药研究所 | Iron scale dendrobium compound preposition and preparation and use |
| CN102302680A (en) * | 2011-09-16 | 2012-01-04 | 蔡光先 | Processing method capable of reserving all components of dendrobium officinale |
| CN104958567A (en) * | 2015-08-04 | 2015-10-07 | 桂林伯林生物技术有限公司 | Dendrobium candidum wall.ex lindl lozenge and preparation method thereof |
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| CN112206282A (en) * | 2020-10-13 | 2021-01-12 | 安徽霍山县药王谷林农科技有限公司 | Pure dendrobium huoshanense ultramicro wall-broken buccal tablet |
| CN113172925A (en) * | 2021-05-17 | 2021-07-27 | 霍山县天下泽雨生物科技发展有限公司 | Preparation method of compound dendrobium huoshanense buccal tablets |
| CN113172925B (en) * | 2021-05-17 | 2022-03-22 | 霍山县天下泽雨生物科技发展有限公司 | Preparation method of compound dendrobium huoshanense buccal tablets |
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