CN104958567A - Dendrobium candidum wall.ex lindl lozenge and preparation method thereof - Google Patents
Dendrobium candidum wall.ex lindl lozenge and preparation method thereof Download PDFInfo
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- CN104958567A CN104958567A CN201510470407.5A CN201510470407A CN104958567A CN 104958567 A CN104958567 A CN 104958567A CN 201510470407 A CN201510470407 A CN 201510470407A CN 104958567 A CN104958567 A CN 104958567A
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- herba dendrobii
- dendrobium candidum
- lindl
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Abstract
The invention discloses a dendrobium candidum wall.ex lindl lozenge and a preparation method thereof. The preparation method comprises the following steps: (1) performing superfine grinding on dried dendrobium candidum wall.ex lindl to obtain dendrobium candidum wall.ex lindl superfine powder; (2) adding water to pulp fresh dendrobium candidum wall.ex lindl so as to obtain a dendrobium candidum wall.ex lindl juice, wherein the ratio of the fresh dendrobium candidum wall.ex lindl to water is (25-150)g:1000ml; (3) weighing the dendrobium candidum wall.ex lindl superfine powder and the dendrobium candidum wall.ex lindl juice according to a ratio of (1500-4000)g:1000ml, and mixing uniformly to obtain a soft material; (4) performing granulation, drying, tabletting and sterilization on the obtained soft material to obtain the lozenge. According to the preparation method disclosed by the invention, the dendrobium candidum wall.ex lindl juice is used as an adhesive and a wetting agent at the same time, and the lozenge can be prepared without adding auxiliary agents of other adhesives and wetting agents, so that the characteristics that the obtained product is green, healthy (without any organic solvent residues) and additive-free can be effectively ensured, and the production cost is greatly reduced because alcohol is avoided from being used as a wetting agent.
Description
Technical field
The present invention relates to a kind of Herba Dendrobii buccal tablet and preparation method thereof, belong to Chinese medicine or health product preparing technical field.
Background technology
The perennial herbaceous plant that grows nonparasitically upon another plant that Herba Dendrobii (Dendrobium candidum Wall.ex Lindl) is the orchid family (Orchidaceae) Dendrobium, has another name called Herba Dendrobii, earrings dendrobium, iron sheet orchid, Herba hedyotis costatae etc.The good reputation that Herba Dendrobii just has since ancient times " in medicine gold ", first of Herba Dendrobii is classified as by Taoist school medical science classics " Taoist Scriptures " " nine large Herba mesonae chinensis ", to be among the peoplely called " help Herba mesonae chinensis ".Record according to the Eastern Han Dynasty Shennong's Herbal, Herba Dendrobii has that damaging the spleen and stomach, eliminating impediment, the therapeutic method to keep the adverse QI flowing downwards, tonifying five ZANG-organs asthenia are thin and weak, reinforcing YIN-essence, take thick the intestines and stomach and effect such as to prolong life of making light of one's life by commiting suicide for a long time.The Pharmacopoeia of the People's Republic of China (2010) is single-row by it, returns stomach, kidney channel, sweet in the mouth, be slightly cold, there is reinforcing stomach reg fluid, the effect of nourishing YIN and clearing away heat, lose for cloudy impairment of body fluid, xerostomia excessive thirst, deficiency of stomach-Yin, lack of appetite is retched, deficiency-heat is not moved back after being ill, hyperactivity of fire caused by deficiency of YIN, hectic fever due to YIN-deficiency consumptive fever, poor vision, muscles and bones flaccidity is soft.Modern medicine study shows, Herba Dendrobii contains type tens kinds of chemical compositions such as dendrobium polysaccharide, aminoacid, trace element, luxuriant and rich with fragrance compounds, Bibenzyl compound, phenolic acid compound, alkaloid, has multiple pharmacological effect such as regulating immunity of organisms, antioxidation, antitumor, resisting fatigue, blood sugar lowering and YIN nourishing and the production of body fluid promoting.
Herba Dendrobii is subject to extensive concern because of the medicine and health care effect of its uniqueness, and its product has fresh bar, Herba Dendrobii extract, soft capsule, buccal tablet etc.There is multiple dendrobium candidum buccal tablets in the market, if publication number is the patents of invention such as CN102406842A, CN102949597A, CN103285242A, all disclose composition and the preparation method of Herba Dendrobii buccal tablet, but, they all with the addition of adjuvant or the additive such as filler, binding agent, lubricant, flavoring agent of certain content in varying degrees, cause drug content relatively to reduce on the one hand; On the other hand, people have also taken a certain amount of additive while taking buccal tablet, there is adverse effect.Publication number is that the patent of invention of CN104605343A discloses a kind of Herba Dendrobii buccal tablet and preparation method thereof, and the solid content of this buccal tablet is 100% Herba Dendrobii, and its preparation method is: get appropriate dendrobium candidum ultrafine powder, with hot water punching slurry, makes binding agent; Separately get after appropriate dendrobium candidum ultrafine powder adds 50 ~ 95% edible ethanols mixings, then add in binding agent and make Herba Dendrobii soft material, then pour oscillating granulation in wet granulator into; Then oven dry, tabletting, sterilizing, packaging, obtains finished product Herba Dendrobii buccal tablet.This tablet adopts 100% Herba Dendrobii composition, adopts Herba Dendrobii punching slurry itself as binding agent in the preparation thus need not add the adjuvants such as binding agent again, product is more good for one's health; But, this buccal tablet needs to add a large amount of 50 ~ 95% ethanol (as wetting agent in preparation process, the ratio of ethanol and dendrobium candidum ultrafine powder is (0.2 ~ 1) mL/g), this has the following disadvantages: on the one hand, a large amount of ethanol add the production cost substantially increasing product; On the other hand, even if select alcohol recycle to utilize, but this can increase the input of equipment, thus causes the further raising of production cost; Again on the one hand, a large amount of ethanol that uses also may make in tablet because affecting drug effect containing residual ethanol.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of green, healthy, additive-free, and solid constituent is Herba Dendrobii buccal tablet of 100% Herba Dendrobii and preparation method thereof.
The manufacture method of Herba Dendrobii buccal tablet of the present invention, comprises the following steps:
1) get dry Herba Dendrobii and carry out micronizing, obtain dendrobium candidum ultrafine powder;
2) get fresh Herba Dendrobii to add water slurrying, obtain Herba Dendrobii juice; Wherein, the proportioning of fresh Herba Dendrobii and water is 25 ~ 150g:1000ml;
3) take dendrobium candidum ultrafine powder and Herba Dendrobii juice by the proportioning of 1500g ~ 4000g:1000ml, mix homogeneously, obtain Herba Dendrobii soft material;
4) gained Herba Dendrobii soft material routinely technique carry out granulating, drying, tabletting, sterilization, obtain Herba Dendrobii buccal tablet.
Applicant finds, the juice of the slurrying gained that added water in specific proportions by fresh Herba Dendrobii has good stickiness.Added water by the fresh Herba Dendrobii juice of slurrying gained of the present invention is applied to the preparation of Herba Dendrobii buccal tablet simultaneously as binding agent and wetting agent, do not need the adjuvant such as binding agent and wetting agent adding other more namely can make buccal tablet, not only effectively can ensure that products obtained therefrom is green, healthy, non-additive feature, also because avoiding using ethanol to reduce production cost significantly as wetting agent.
The step 1 of technique scheme) in, the Herba Dendrobii that described dry Herba Dendrobii obtains after referring to and being dried by fresh Herba Dendrobii branch.Can obtain by the drying technology of existing routine, also can directly commercially obtain, usually require water content≤10% of dry Herba Dendrobii.In this step, normally Herba Dendrobii is crushed to below 400 orders, preferred powder is broken to 400 ~ 600 orders.
The step 2 of technique scheme) in, described fresh Herba Dendrobii refers to fresh Herba Dendrobii branch.The proportioning of described fresh Herba Dendrobii and water is preferably 50 ~ 150g:1000ml, is more preferably 80 ~ 120g:1000ml.In this step, normally fresh Herba Dendrobii and water are placed in beater (as fruit pulping machince) making beating, cross 100 ~ 200 mesh sieves, permeate carries out homogenizing with high pressure homogenizer again, and (homogenization pressure is generally 20 ~ 40MPa, preferably also sterilisation step is comprised after homogenizing, sterilization temperature is 90 ~ 95 DEG C, and the time is 30 ~ 60s), obtain Herba Dendrobii juice.
The step 3 of technique scheme) in, the proportioning of dendrobium candidum ultrafine powder and Herba Dendrobii juice is preferably 1500 ~ 3000g:1000ml, is more preferably 2000 ~ 3000g:1000ml.
The step 4 of technique scheme) in, described granulation, tabletting and sterilization operation are same as the prior art.
The present invention also comprises the Herba Dendrobii buccal tablet obtained by said method.
Compared with prior art, feature of the present invention is:
1, adopt 100% Herba Dendrobii composition, do not add any adjuvant, the Herba Dendrobii buccal tablet composition made by guarantee is 100% pure powder.
2, the juice of slurrying gained of being added water by fresh Herba Dendrobii is applied to the preparation of Herba Dendrobii buccal tablet simultaneously as binding agent and wetting agent, do not need the adjuvant such as binding agent and wetting agent adding other more namely can make buccal tablet, not only effectively can ensure products obtained therefrom green, healthy (without any organic solvent residual), non-additive feature, also because avoiding using ethanol to reduce production cost significantly as wetting agent, the harm of edible additive also can be avoided.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is described in further detail, and to understand content of the present invention better, but the present invention is not limited to following examples.
Embodiment 1
1) dry: choosing fresh Herba Dendrobii branch is raw material, dries after being cleaned up by fresh Herba Dendrobii branch, be then placed in dehydrator and dry under 60 ~ 70 DEG C of conditions (controlling moisture is 8%), obtain dry Herba Dendrobii;
2) pulverize: dry for gained Herba Dendrobii is placed in super micron mill and pulverizes, cross 400 mesh sieves, obtain dendrobium candidum ultrafine powder;
3) slurrying: separately get fresh Herba Dendrobii branch and be placed in fruit pulping machince, the ratio being 100g:1000mL in fresh Herba Dendrobii branch and distilled water adds water making beating, cross 200 mesh sieves, then carry out homogenizing with high pressure homogenizer, homogenization pressure is 40MPa, makes the fresh juice of stickiness, sterilizing in short-term afterwards, (temperature is 90 ~ 95 DEG C, time is 60s), be cooled to room temperature after sterilization, obtain Herba Dendrobii juice;
4) mix: by step 2) gained dendrobium candidum ultrafine powder and step 3) gained Herba Dendrobii juice mixes in the ratio of 2500g:1000ml, and stirs, and obtains Herba Dendrobii soft material;
5) granulate: by step 4) gained Herba Dendrobii soft material put into wet granulator routinely technique granulate;
6) dry: by step 5) the gained Herba Dendrobii grain that wets carries out drying (drying condition is 55 ~ 60 DEG C, controls moisture 2 ~ 4%), obtains dry granule;
7) tabletting: by step 6) the dry granule of gained be placed in tablet machine routinely technique carry out tabletting (every sheet 0.5g).
8) sterilize: gained tablet irradiates 20min under being placed in ultraviolet, namely obtains Herba Dendrobii buccal tablet.
Embodiment 2
Repeat embodiment 1, unlike:
Step 3) in the ratio of fresh Herba Dendrobii branch and distilled water be: 25g:1000mL;
Step 4) in the ratio of dendrobium candidum ultrafine powder and Herba Dendrobii juice be: 3500g:1000ml.
Embodiment 3
Repeat embodiment 1, unlike:
Step 3) in the ratio of fresh Herba Dendrobii branch and distilled water be: 50g:1000mL;
Step 4) in the ratio of dendrobium candidum ultrafine powder and Herba Dendrobii juice be: 3000g:1000ml.
Embodiment 4
Repeat embodiment 1, unlike:
Step 3) in the ratio of fresh Herba Dendrobii branch and distilled water be: 150g:1000mL;
Step 4) in the ratio of dendrobium candidum ultrafine powder and Herba Dendrobii juice be: 1500g:1000ml.
Embodiment 5
Repeat embodiment 1, unlike:
Step 3) in the ratio of fresh Herba Dendrobii branch and distilled water be: 120g:1000mL;
Step 4) in the ratio of dendrobium candidum ultrafine powder and Herba Dendrobii juice be: 4000g:1000ml.
Embodiment 6
Repeat embodiment 1, unlike:
Step 3) in the ratio of fresh Herba Dendrobii branch and distilled water be: 80g:1000mL;
Step 4) in the ratio of dendrobium candidum ultrafine powder and Herba Dendrobii juice be: 2000g:1000ml.
Carry out Quality Detection to the character of the obtained Herba Dendrobii buccal tablet of embodiment 1 and quality, result is respectively as shown in following table 1 and table 2:
Table 1: organoleptic detection result
| Test item | Result |
| Color and luster | In light green color or yellow green |
| Abnormal smells from the patient | Raw material abnormal smells from the patient inherently, free from extraneous odour |
| Tissue morphology | Oval lamellar, consolidation |
| Impurity | Without the visible exogenous impurity of naked eyes |
Table 2: microorganism detection result
Claims (6)
1. a manufacture method for Herba Dendrobii buccal tablet, comprises the following steps:
1) get dry Herba Dendrobii and carry out micronizing, obtain dendrobium candidum ultrafine powder;
2) get fresh Herba Dendrobii to add water slurrying, obtain Herba Dendrobii juice; Wherein, the proportioning of fresh Herba Dendrobii and water is 25 ~ 150g:1000ml;
3) take dendrobium candidum ultrafine powder and Herba Dendrobii juice by the proportioning of 1500g ~ 4000g:1000ml, mix homogeneously, obtain Herba Dendrobii soft material;
4) gained Herba Dendrobii soft material routinely technique carry out granulating, drying, tabletting, sterilization, obtain Herba Dendrobii buccal tablet.
2. manufacture method according to claim 1, is characterized in that: step 2) in, the proportioning of described fresh Herba Dendrobii and water is 50 ~ 150g:1000ml.
3. manufacture method according to claim 1, is characterized in that: step 2) in, the proportioning of described fresh Herba Dendrobii and water is 80 ~ 120g:1000ml.
4. manufacture method according to claim 1, is characterized in that: step 3) in, take dendrobium candidum ultrafine powder and Herba Dendrobii juice by the proportioning of 1500 ~ 3000g:1000ml.
5. manufacture method according to claim 1, is characterized in that: step 3) in, take dendrobium candidum ultrafine powder and Herba Dendrobii juice by the proportioning of 2000 ~ 3000g:1000ml.
6. the Herba Dendrobii buccal tablet that method according to any one of Claims 1 to 5 is obtained.
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| CN201510470407.5A CN104958567A (en) | 2015-08-04 | 2015-08-04 | Dendrobium candidum wall.ex lindl lozenge and preparation method thereof |
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| CN201510470407.5A CN104958567A (en) | 2015-08-04 | 2015-08-04 | Dendrobium candidum wall.ex lindl lozenge and preparation method thereof |
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Cited By (7)
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| CN105410588A (en) * | 2015-11-06 | 2016-03-23 | 四川兴食尚科技有限公司 | Kiwi effervescent tablets and preparation technology thereof |
| CN105748944A (en) * | 2016-05-05 | 2016-07-13 | 上海雷允上药业有限公司神象参茸分公司 | Preparation method of dendrobium officinale decoction pieces |
| CN105796917A (en) * | 2016-04-01 | 2016-07-27 | 赵加棚 | Water extraction method for fresh natural dendrobium officinale |
| CN106039032A (en) * | 2016-07-15 | 2016-10-26 | 四川大学 | Cordyceps sinensis composition, compound preparation, preparation method of compound preparation and application of cordyceps sinensis composition |
| CN106420644A (en) * | 2016-11-22 | 2017-02-22 | 广西玉林容山堂生物科技有限公司 | Dendrobium officinale buccal tablet and preparation method thereof |
| CN110025730A (en) * | 2019-04-28 | 2019-07-19 | 九仙尊霍山石斛股份有限公司 | A kind of Dendrobidium huoshanness lozenge and preparation method thereof |
| CN112516254A (en) * | 2020-12-09 | 2021-03-19 | 云南中医药大学 | Dendrobium officinale instant granules and preparation method thereof |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105410588A (en) * | 2015-11-06 | 2016-03-23 | 四川兴食尚科技有限公司 | Kiwi effervescent tablets and preparation technology thereof |
| CN105796917A (en) * | 2016-04-01 | 2016-07-27 | 赵加棚 | Water extraction method for fresh natural dendrobium officinale |
| CN105748944A (en) * | 2016-05-05 | 2016-07-13 | 上海雷允上药业有限公司神象参茸分公司 | Preparation method of dendrobium officinale decoction pieces |
| CN106039032A (en) * | 2016-07-15 | 2016-10-26 | 四川大学 | Cordyceps sinensis composition, compound preparation, preparation method of compound preparation and application of cordyceps sinensis composition |
| CN106420644A (en) * | 2016-11-22 | 2017-02-22 | 广西玉林容山堂生物科技有限公司 | Dendrobium officinale buccal tablet and preparation method thereof |
| CN110025730A (en) * | 2019-04-28 | 2019-07-19 | 九仙尊霍山石斛股份有限公司 | A kind of Dendrobidium huoshanness lozenge and preparation method thereof |
| CN110025730B (en) * | 2019-04-28 | 2021-11-26 | 九仙尊霍山石斛股份有限公司 | Dendrobium huoshanense buccal tablets and preparation method thereof |
| CN112516254A (en) * | 2020-12-09 | 2021-03-19 | 云南中医药大学 | Dendrobium officinale instant granules and preparation method thereof |
| CN112516254B (en) * | 2020-12-09 | 2022-05-20 | 云南中医药大学 | Dendrobium officinale instant granules and preparation method thereof |
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Application publication date: 20151007 |