CN106039032A - Cordyceps sinensis composition, compound preparation, preparation method of compound preparation and application of cordyceps sinensis composition - Google Patents

Cordyceps sinensis composition, compound preparation, preparation method of compound preparation and application of cordyceps sinensis composition Download PDF

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Publication number
CN106039032A
CN106039032A CN201610561721.9A CN201610561721A CN106039032A CN 106039032 A CN106039032 A CN 106039032A CN 201610561721 A CN201610561721 A CN 201610561721A CN 106039032 A CN106039032 A CN 106039032A
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cordyceps
preparation
compound preparation
step
described
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CN201610561721.9A
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Chinese (zh)
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曾里
朱伦
朱一伦
白天松
白长林
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四川大学
成都百世源生物科技有限公司
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Priority to CN201610561721.9A priority Critical patent/CN106039032A/en
Publication of CN106039032A publication Critical patent/CN106039032A/en

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • A61K36/062Ascomycota
    • A61K36/066Clavicipitaceae
    • A61K36/068Cordyceps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/898Orchidaceae (Orchid family)
    • A61K36/8984Dendrobium

Abstract

The invention discloses a cordyceps sinensis composition, a compound preparation, a preparation method of the compound preparation and application of the cordyceps sinensis composition to preparation of human health care products. The cordyceps sinensis composition disclosed by the invention is prepared from the following raw materials in parts by weight: 50 to 70 parts of superfine powder of cordyceps sinensis, and 30 to 50 parts of superfine powder of dendrobium officinale; the diameter of the superfine powder of cordyceps sinensis is 10 to 30 [mu]m; the diameter of the superfine powder of dendrobium officinale is 10 to 30 [mu]m. The pharmaceutical preparation, namely, the compound preparation, made of the composition has the characteristics that the raw materials are fewer, that is, only cordyceps sinensis and dendrobium officinale are composed; the use ratios of the effective components of the herbs are high; the preparation process is simple; adding and homogenizing are not needed; a freeze drying process is not required; the preparation cost is low; the curative effect of the compound preparation on human health care, especially in the anti-tumor field, is high.

Description

A kind of cordyceps sinensis composition, compound preparation and its preparation method and application

Technical field

The present invention relates to compound preparation of a kind of Chinese crude drug and its preparation method and application, be specifically related to a kind of Cordyceps Compound preparation, the preparation method of this compound preparation and application in healthcare thereof.

Background technology

Cordyceps (Ophicordyceps sinensis) is section ergot fungus cordyceps sinensis bacterium, has another name called China worm Grass, is traditional rare Chinese medicine.According to the Pharmacopoeia of the People's Republic of China, Cordyceps nature and flavor are sweet, flat;Invigorating the lung and the kidney, only Blood, reduce phlegm;Cure mainly chronic cough dyspnea due to deficiency, chronic cough hemoptysis, impotence and seminal emission, soreness of waist and knee joint.Modern medicine and clinical research show, the worm summer in winter Grass mainly has antitumor, hepatoprotective protects kidney, regulation immunity, to effects such as the regulations of androgen secretion.

Herba Dendrobii (Dendrobium officinale Kimura et Migo) is the orchid family Dendrobium perennial herb Plant, has another name called Herba hedyotis costatae, Herba Dendrobii, is the traditional rare Chinese medicine of China, the most just has the good reputation of " gold in medicine ", Herba Dendrobii is classified as by " Taoist Scriptures " first of " nine big Herba mesonae chinensis ", among the people is called again " help Herba mesonae chinensis ".According to " China's people's republicanism State's pharmacopeia " described, Herba Dendrobii nature and flavor are sweet, be slightly cold;Reinforcing stomach reg fluid, nourishing YIN and clearing away heat;Curing mainly cloudy impairment of body fluid to lose, xerostomia excessive thirst, lack of appetite is retched, Deficiency-heat after being ill, poor vision.Modern medicine study shows, Herba Dendrobii have regulation immunity of organisms, blood sugar lowering, resisting fatigue, Antitumor, antioxidative effect.

The Chinese herbal medicine that prior art is famous and precious to both, have developed multi-medicament compositions, such as patent CN 102240365 A provide the pharmaceutical composition of a kind of enhancing human body immunity power, by artificial cordyceps militaris fruiting body, Herba Dendrobii, Calcium sulphate dihydrate, microcrystalline Cellulose, polyvinylpolypyrrolidone, hypromellose and magnesium stearate;Patent CN 103432421 A Providing the pharmaceutical composition of a kind of enhancing immunity, constituent is Cordyceps, Herba Dendrobii, Radix Panacis Quinquefolii extract, pellet Conopsea extraction and Radix Notoginseng extract;Patent CN 102349975 B provides a kind of Dendrobium officinale health product compositions, a combination thereof Thing composition includes fresh Herba Dendrobii extract, Fructus Lycii extract, Cordyceps powder extract and Radix Panacis Quinquefolii extract, is guaranteeing On the premise of enough enhancing immunity health-care effects, also reduce production cost.

But, the compositions in above-mentioned patent generally exists that effective ingredient dissolution is low, product health care is inefficient Shortcoming, additionally in pharmaceutical composition, component is added too much, and famous and precious Chinese crude drug selected mostly by raw material, causes preparation cost very Height, complex technical process.There is presently no a kind of pharmaceutical composition of relevant report proposition, at anti-tumor aspect, there is well treatment Effect, is only to be made up of Cordyceps and Herba Dendrobii, without adding any adjuvant;Its effective ingredient dissolution simultaneously Degree is high, product good health care effect, and preparation technology is simple, Cordyceps with low cost and Herba Dendrobii compositions.

Summary of the invention

The purpose of the present invention is aiming at the deficiencies in the prior art, and provide a kind of Cordyceps compound preparation and Its preparation method, the raw material components of this pharmaceutical preparation is few, is only made up of Cordyceps and Herba Dendrobii, effective ingredient profit High by rate, and preparation technology is simple, with low cost, said preparation especially has well at anti-tumor aspect in terms of body-care Curative effect.

An object of the present invention is to provide a kind of cordyceps sinensis composition, and said composition is by the raw material group of following weight parts Become: Cordyceps superfine powder 50-70 part, dendrobium candidum ultrafine powder 30-50 part;The particle diameter of described Cordyceps superfine powder be 10~ 30 μm, the particle diameter of described dendrobium candidum ultrafine powder is 10~30 μm.

The composite formula of the present invention combines the feature of two kinds of raw materials, in the premise giving full play to two kinds of raw material drug effects Under, successfully have developed a kind of only containing Cordyceps and the product of Herba Dendrobii, without adding any adjuvant, it is ensured that Zero interpolation of other adjuvant and the top grade of product.The present invention after substantial amounts of experimentation, surprisingly, it is found that, by ferrum After skin Herba Dendrobii is prepared as superfine powder, it is possible to play good binding agent effect, directly can make with Cordyceps superfine powder Grain and shaping, it addition, Cordyceps and Herba Dendrobii are prepared as superfine powder by the present invention, when its particle diameter is between 10~30 μm, Can improve the dissolution of effective ingredient largely, two kinds of superfine powder are mutually promoted so that effective ingredient is abundant simultaneously Dissolution, the two dissolution in human gastric juice all up to more than 90%, it is possible to fully ensure that the performance of drug effect, improve medicine Bioavailability, and save dosage.Root it is documented, Herba Dendrobii is sweet, is slightly cold, and belongs to clear and rich product, both stomach reinforcing Raw Feng, nourishing YIN and clearing away heat again;Cordyceps is sweet, temperature, tonifying deficiency, benefit vital essence, relieving cough and resolving phlegm;The property of medicine of Herba Dendrobii is cool property, And the property of medicine of Cordyceps is hot, the people of cool gonosome matter nourishes the Herba Dendrobii of cool property for a long time, is to make the matter worse, febricity body constitution People nourish for a long time hot Cordyceps, be to pour oil on the fire.The present invention disclosure satisfy that the demand of nourishing of various crowd, will both compatibilities Together, the most comprehensively, coordinate the most very much and balance, it is possible to the crowd being suitable for various body constitution nourishes, the people of febricity body constitution Need not be again because the property of medicine of Cordyceps be hot and cannot nourish for a long time, the people of cool gonosome matter is without because Herba Dendrobii The property of medicine is cool property and gives up its medical value.

The two can be carried out compatibility by inventive formulation well, has simultaneously worked as the effect of Synergistic so that compound recipe Overcome the limitation of single raw material, surmount again effect of single raw material with compound recipe.The main component of Cordyceps is Cordyceps gland Glycosides, now there are some researches show, adenosine is a kind of endogenous nucleoside spreading all over human body cell, can phosphorylated generation adenylic acid, participate in Energy metabolism of myocardial, also acts as dilating coronary blood vessel simultaneously, increases blood flow, and to the many of cardiovascular system and human body, other is System and tissue all have physiological action;And Herba Dendrobii contains abundant water soluble polysaccharide, it is a para-immunity reinforcing agent, has reality Testing and show, it, to improving the outer weekly form cell of mice and promoting that lymphocyte produces shifter factor and has obvious effect, can improve first The weakness symptom of high type mice, has the effects such as suppression tumor, defying age and expansion blood vessel.

The curative effect that the compound recipe of the present invention possesses relatively folk prescription is greatly improved, this medicine rich in abundant polysaccharide component, And polysaccharide is antineoplastic main active;In addition the sterols contained in Cordyceps and cordycepin, Herba Dendrobii In the EN that contains and chrysotoxene all have certain antitumous effect, this medicine in terms of body-care especially at antitumor Aspect serves good curative effect.The compound preparation of the present invention is through mice anti-tumor experiment, as shown in table 2 in experimental example 2, it is possible to Well extend the life cycle suffering from mice with tumor and play certain antitumous effect.

Preferably, the particle diameter of described Cordyceps superfine powder is 16~20 μm, and the particle diameter of described dendrobium candidum ultrafine powder is 16~20 μm, in this particle size range, the effective ingredient dissolution of Cordyceps and Herba Dendrobii is the highest, and drug effect is the most notable.

Second object of the present invention is to provide a kind of described Cordyceps compound preparation and preparation method thereof, described winter worm Summer grass compound preparation includes capsule, tablet or pill, is made up of above-mentioned cordyceps sinensis composition, the preparation method bag of described preparation Include following steps:

(1) micronizing: by weight, weighs 50-70 part Cordyceps and 26-44 part Herba Dendrobii respectively, uses Both is crushed to the superfine powder that particle diameter is 10~30 μm by superfine grinding method, obtains Cordyceps superfine powder and Herba Dendrobii Superfine powder, will the two mix homogeneously;

(2) preparation of Herba Dendrobii binding agent: by weight, separately takes the Herba Dendrobii that 4~6 parts of particle diameters are 10~30 μm Superfine powder, adds in hot water by weight the ratio for 1:3~5 and is sufficiently mixed, prepare Herba Dendrobii binding agent;

(3) pelletize: pelletize after step (2) gained binding agent is mixed homogeneously with step (1) gains;

(4) dry: step (3) gains are put into baking oven, dry to water content less than 5%;

(5) shape: after being shaped at normal temperatures by step (4) gains, prepare Cordyceps compound preparation.

In preparation method of the present invention, Cordyceps and Herba Dendrobii are carried out micronizing and obtains superfine powder After, it has unexpectedly been found that, by Herba Dendrobii binding agent can be made after directly mixing with dendrobium candidum ultrafine powder with hot water, it is possible to Reshape after well Cordyceps superfine powder and dendrobium candidum ultrafine powder being sufficiently mixed granulation, and any auxiliary without adding Material, the preparation method of the present invention, it is not necessary to add homogenizing, it is not necessary to freezing dry process, shaping of pelletizing the most at normal temperatures, whole Individual preparation technology is simple, and raw material components is few, and preparation cost is cheap.

Preferably, step (1) and step (2) use Cordyceps superfine powder and iron sheet stone that superfine grinding method obtains The particle diameter of dry measure used in former times superfine powder is 16~20 μm, and the Cordyceps compound preparation effective ingredient dissolution prepared under this particle diameter is more Good.

Preferably, described in step (1), micronizing is 50HZ micronizing.

Preferably, described in step (2), the temperature of hot water is 80~95 DEG C.

Preferably, the temperature dried described in step (4) is 40~60 DEG C.

Preferably, described in step (5), manufacturing process includes making capsule, tablet or pill.

Third object of the present invention is to provide the application in terms of preparing health product of a kind of described cordyceps sinensis composition.

The compound preparation that the cordyceps sinensis composition of the present invention prepares can treat phthisical cough expectorant blood, night sweat, sexual impotence, something lost The diseases such as essence, jaundice, pulmonary tuberculosis and old weak, chronic cough and asthma, have the strong effect taken in concurrently and hold back calmness.Blood sugar lowering can be played Effect, enhancing human body immunity power, heart can be played a protective role, blood system is damaged maintenance and to respiratory system Improve reparation to have certain effect, immune enhancing and protection and preventing and treating to digestive system are respectively provided with well treatment Effect.Special instruction, the compound preparation of the present invention all serves at anti-tumor aspect relatively free drug and other combination drug More preferably effect.

What the present invention compared with prior art possessed has the beneficial effects that: the raw material of the present invention only selects Cordyceps and ferrum Skin Herba Dendrobii, has accomplished zero interpolation of adjuvant, it is ensured that the top grade of this pharmaceutical preparation, and compared with other compound preparation, raw material becomes This is less expensive, the preparation of superfine powder simultaneously so that effective ingredient can be fully dissolved out, lifting evident in efficacy, and can Meet the demand of different crowd, in terms of body-care, especially have good curative effect at anti-tumor aspect.

Detailed description of the invention

In order to make the purpose of the present invention, technical scheme and advantage clearer, below in conjunction with embodiment to the present invention It is specifically described, it is necessary to it is noted that following example are used only for being explained and illustrated the present invention, be not used to Limit the present invention.Some nonessential improvement and adjustment that those skilled in the art are made according to foregoing invention content, still belong to In protection scope of the present invention.

Embodiment 1

Carry out the preparation of Cordyceps compound preparation according to the following steps:

(1) by weight, weigh 50 parts of Cordyceps fresh goods and 44 parts of iron-sheet dendrobe fresh products respectively, use pulverizer to enter Both is crushed to the superfine powder that particle diameter is 10 μm by row 50HZ micronizing, obtains Cordyceps superfine powder and Herba Dendrobii surpasses Micropowder, by prepared Cordyceps superfine powder and dendrobium candidum ultrafine powder mix homogeneously;

(2) by weight, separately take the dendrobium candidum ultrafine powder that 6 parts of particle diameters are 10 μm, add by weight the ratio for 1:3 Enter in the hot water of 80 DEG C and be sufficiently mixed, prepare Herba Dendrobii binding agent;

(3) pelletize after step (2) gained binding agent being mixed homogeneously with step (1) gains;

(4) step (3) gains are put into baking oven, dry at 40 DEG C to water content less than 5%;

(5) using tabletting method, tabletting prepares Cordyceps compound buccal lozenge the most at normal temperatures.

Embodiment 2

Carry out the preparation of Cordyceps compound preparation according to the following steps:

(1) by weight, weighing 60 parts of Cordyceps fresh goods and 35 parts of iron-sheet dendrobe fresh products respectively, employing pulverizer will Both is crushed to the superfine powder that particle diameter is 20 μm, by Cordyceps superfine powder and dendrobium candidum ultrafine powder mix homogeneously;

(2) by weight, separately take the dendrobium candidum ultrafine powder that 5 parts of particle diameters are 20 μm, add by weight the ratio for 1:4 Enter in 90 DEG C of hot water and be sufficiently mixed, prepare Herba Dendrobii binding agent;

(3) pelletize after step (2) gained binding agent being mixed homogeneously with step (1) gains;

(4) step (3) gains are put into baking oven, dry at 50 DEG C to water content be 4%;

(5) use capsule method processed, prepare Cordyceps compound capsule the most at normal temperatures.

Embodiment 3

Carry out the preparation of Cordyceps compound preparation according to the following steps:

(1) by weight, weigh 70 parts of Cordyceps fresh goods and 26 parts of iron-sheet dendrobe fresh products respectively, use pulverizer to enter Both is crushed to the superfine powder that particle diameter is 30 μm by row 50HZ micronizing, by Cordyceps superfine powder and Herba Dendrobii ultra micro Powder mix homogeneously;

(2) by weight, separately take the dendrobium candidum ultrafine powder that 4 parts of particle diameters are 30 μm, add by weight the ratio for 1:5 Enter in 95 DEG C of hot water and be sufficiently mixed, prepare Herba Dendrobii binding agent;

(3) pelletize after step (2) gained binding agent being mixed homogeneously with step (1) gains;

(4) step (3) gains are put into baking oven, dry at 60 DEG C to water content be 3%;

(5) use pill method, prepare Cordyceps compound recipe pill the most at normal temperatures.

Embodiment 4

In addition to the particle diameter of Cordyceps superfine powder and dendrobium candidum ultrafine powder is set to 16 μm, remaining and embodiment 1 Identical, prepare Cordyceps compound buccal lozenge.

Embodiment 5

In addition to the particle diameter of Cordyceps superfine powder and dendrobium candidum ultrafine powder is set to 18 μm, remaining and embodiment 2 Identical, prepare Cordyceps compound capsule.

Experimental example 1

Taking dilute hydrochloric acid 16mL, being diluted with water to pH is 1.5, carries out artificial simulation gastric juices environment, inquires into Cordyceps ultra micro Powder and the dendrobium candidum ultrafine powder effective ingredient dissolution rate size in simulated gastric fluid, result is as shown in table 1, and wherein matched group is Iron-sheet dendrobe fresh product and Cordyceps fresh goods are carried out traditional decoction:

1 60 minutes human gastric juice dissolution rates of table

As it can be seen from table 1 the Cordyceps compound preparation effective ingredient dissolution prepared in the present embodiment It is greatly improved compared to traditional decoction method, and particle diameter is imitated in the effective ingredient dissolution of the embodiment 2 and 4-3 of 16~20 μm Fruit is better than embodiment 1 and 3.

Experimental example 2

The Cordyceps compound preparation present invention prepared carries out antitumor performance test to mice.

Experiment chooses 100 BALB/c mouse being inoculated with ehrlich ascites cell and 100 to be inoculated with H22 hepatocarcinoma thin The BALB/c mouse of born of the same parents, carries out the Cordyceps compound preparation Aqueous extracts in subcutaneous injection embodiment 1-5 respectively, takes note every day Penetrating once, injection dosage is 2mg, observes survival period and the body weight change situation of mice, and wherein comparison 1 for choosing weight portion is The Cordyceps Aqueous extracts of 100 parts of particle diameter 20 μm, comparison 2 is to choose the Herba Dendrobii water that weight portion is 100 parts of particle diameter 20 μm to carry Liquid, comparison 3 is to choose particle diameter to be the mixture Aqueous extracts that weight portion is 50 parts of Herba Dendrobii and 50 parts of Cordyceps of 35 μm, Comparison 4 is to choose particle diameter to be the mixture Aqueous extracts that weight portion is 50 parts of Herba Dendrobii and 50 parts of Cordyceps of 8 μm, gained Result is as shown in table 2:

Table 2

From table 2 it can be seen that antitumor is played good effect by the Cordyceps compound preparation of the present invention, simultaneously can Improve the immunocompetence of mice, but outside the particle diameter of the present invention, the antitumous effect of mice will be deteriorated.

Claims (10)

1. a cordyceps sinensis composition, it is characterised in that be made up of the raw material of following weight parts: Cordyceps superfine powder 50- 70 parts, dendrobium candidum ultrafine powder 30-50 part;The particle diameter of described Cordyceps superfine powder is 10~30 μm, and described Herba Dendrobii surpasses The particle diameter of micropowder is 10~30 μm.
Cordyceps sinensis composition the most according to claim 1, it is characterised in that the particle diameter of described Cordyceps superfine powder is 16~20 μm, the particle diameter of described dendrobium candidum ultrafine powder is 16~20 μm.
3. a kind of Cordyceps compound preparation being made up of the compositions described in claim 1 or 2, it is characterised in that described system Agent includes capsule, tablet or pill.
The preparation method of a kind of Cordyceps compound preparation the most as claimed in claim 3, it is characterised in that described method includes Following steps:
(1) micronizing: by weight, weighs 50-70 part Cordyceps and 26-44 part Herba Dendrobii respectively, uses ultra micro Both is crushed to the superfine powder that particle diameter is 10~30 μm by breaking method, obtains Cordyceps superfine powder and Herba Dendrobii ultra micro Powder, will the two mix homogeneously;
(2) preparation of Herba Dendrobii binding agent: by weight, separately takes the Herba Dendrobii ultra micro that 4~6 parts of particle diameters are 10~30 μm Powder, adds in hot water by weight the ratio for 1:3~5 and is sufficiently mixed, prepare Herba Dendrobii binding agent;
(3) pelletize: pelletize after step (2) gained binding agent is mixed homogeneously with step (1) gains;
(4) dry: step (3) gains are put into baking oven, dry to water content less than 5%;
(5) shape: after being shaped at normal temperatures by step (4) gains, prepare Cordyceps compound preparation.
The preparation method of Cordyceps compound preparation the most according to claim 4, it is characterised in that step (1) and step (2) Cordyceps superfine powder and the particle diameter of dendrobium candidum ultrafine powder that in, employing superfine grinding method obtains are 16~20 μm.
6. according to the preparation method of the Cordyceps compound preparation described in claim 4 or 5, it is characterised in that institute in step (1) Stating superfine grinding method is 50HZ micronizing.
7. according to the preparation method of the Cordyceps compound preparation described in claim 4 or 5, it is characterised in that institute in step (2) The temperature stating hot water is 80~95 DEG C.
8. according to the preparation method of the Cordyceps compound preparation described in claim 4 or 5, it is characterised in that institute in step (4) The temperature stating drying is 40~60 DEG C.
9. according to the preparation method of the Cordyceps compound preparation described in claim 4 or 5, it is characterised in that institute in step (5) State manufacturing process to include making capsule, tablet or pill.
10. the application in terms of preparing health product of the cordyceps sinensis composition described in claim 1 or 2.
CN201610561721.9A 2016-07-15 2016-07-15 Cordyceps sinensis composition, compound preparation, preparation method of compound preparation and application of cordyceps sinensis composition CN106039032A (en)

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