CN1977944A - Red ginseng and lilyturf root soft capsule and its preparing method - Google Patents
Red ginseng and lilyturf root soft capsule and its preparing method Download PDFInfo
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- CN1977944A CN1977944A CN 200510126088 CN200510126088A CN1977944A CN 1977944 A CN1977944 A CN 1977944A CN 200510126088 CN200510126088 CN 200510126088 CN 200510126088 A CN200510126088 A CN 200510126088A CN 1977944 A CN1977944 A CN 1977944A
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Abstract
The present invention discloses a Shenmai soft capsule with the functions of nourishing yin and promoting the production of the body fluid. It is made up by using 6 Chinese medicinal materials of red ginseng, adenophora root, ophiopogen tuber, polygonatum root, Chinese yam and lyceum berry and at least on kind of medicinal auxiliary material selected from vegetable oil or polyethylene glycol or ethylene glycol monoethyl ether through a certain preparation process.
Description
Technical field
What the present invention relates to is a kind of Chinese medicine novel form and preparation method thereof, especially relates to Chinese medicinal soft capsule of a kind of YIN nourishing and the production of body fluid promoting and preparation method thereof.
Background technology
The compound preparation that Chinese medicine Rhizoma Zingiberis Recens granule is made up of Six-element Chinese medicines such as Radix Ginseng Rubra, Radix Adenophorae, Radix Ophiopogonis, Rhizoma Polygonati, Rhizoma Dioscoreae, Fructus Lycii, this prescription have the effect that supplementing QI and nourishing YIN, promoting the production of body fluid to quench thirst, yin fluid astringing take off admittedly.Modern medicine think have heart tonifying, boost, coronary artery dilating, increase blood supply of cardiac muscle, reduce myocardial oxygen consumption, remove oxygen-derived free radicals, the effect of blood sugar lowering, tentative cerebral ischemia has the anti-hypoxia protective effect.Be used for the treatment of diseases such as emaciation and sallow complexion, soreness of the waist and knees, inappetence, dizziness and blurred vision, shortness of breath and palpitation, Tianjin are thirsty less, neurasthenia.The product of listing is a granule at present, is produced by many enterprises, and market sale is steady, has higher popularity in the middle at home medicine.Granule is a national medical insurance Class A kind.Its process characteristic be with the prescription Chinese crude drug through extract, concentrate, dry, add sucrose, granulation, granule.This product contains a large amount of sugar part, is not suitable for diabetic to take, be old man patient and this medicine is primarily aimed at, so the limitation that this medicine uses has some idea of.In addition, when the preparation granule, can produce bigger dust, can endanger the healthy of employee for a long time in the past, also pollute the environment simultaneously.
" a kind of ginseng and ophiopogon root dripping pill that is used for YIN nourishing and the production of body fluid promoting and preparation method thereof " (application number CN200510008905.4) described the preparation method of ginseng and ophiopogon root dripping pill, product quality compared with former preparation be improved to some extent.
" total Saponin drop pill of Rhizoma Zingiberis Recens and preparation method thereof " (application number CN200310121712.0) then is again through macroporous resin adsorption after alcohol extraction, purification and the preparation that makes of total saponins effective site, but lost the mucopolysaccharide composition, this part then has stronger effect to enhance immunity.
Discover through this seminar, only with Radix Ginseng Rubra and Radix Ophiopogonis prescription, if the preparation of selecting suitable extraction process to make has similar clinical efficacy to above-mentioned symptom, so obtain in the present invention embodying.
Summary of the invention
The object of the present invention is to provide red ginseng and lilyturf root soft capsule of a kind of YIN nourishing and the production of body fluid promoting, invigorating the kidney and strengthening the bones and preparation method thereof, overcome the problem that existing granule exists, have that stripping is fast, dosage accurately, the unsuitable moisture absorption, good stability, characteristics that curative effect is high.And this product is not moisture, belongs to a kind of advanced person's non-aqueous soft capsule production technology.
Red ginseng and lilyturf root soft capsule of the present invention is made up of content and softgel shell two parts, content comprises Radix Ginseng Rubra, Radix Ophiopogonis two flavor Chinese medicinal ingredients at least, alternative add in the four flavor Chinese medicines such as Radix Adenophorae, Rhizoma Polygonati, Rhizoma Dioscoreae, Fructus Lycii simply or the number flavor, above-mentioned Chinese medicine extract and pharmaceutic adjuvant weight proportion are:
Active ingredient 10-70%
Pharmaceutic adjuvant 30-90%
The weight proportion of above-mentioned various components is preferably as follows:
Active ingredient 15-60%
Pharmaceutic adjuvant 40-85%
Among the present invention in the content weight proportion of various components as follows:
Extract 10-70%
Diluent 30-80%
Surfactant 1-10%
Suspending agent 1-5%
The weight proportion of above-mentioned various components is preferably as follows:
Extract 15-60%
Diluent 35-65%
Surfactant 3-8%
Suspending agent 2-4%
Pharmaceutic adjuvant of the present invention refers to ethylene glycol monomethyl ether.
Pharmaceutic adjuvant of the present invention can also be the combination of diluent, surfactant, suspending agent, diluent can be one or more in Polyethylene Glycol (PEG) and the vegetable oil, PEG comprises liquid PEG-400, PEG-600 etc., also can cooperate and add a certain amount of solid-state PEG, as PEG6000 etc.; Vegetable oil comprises Semen Maydis oil, soybean oil, salad oil, Oleum Brassicae campestris, tea tree oil, Cortex cocois radicis wet goods.
Surfactant can be one or more in tween, span, lecithin, the polyoxyethylene castor oil.
Suspending agent can be one or more in Cera Flava, ethyl cellulose, hydrogenated palm oil, the mono stearate glyceryl ester etc.
Various components proportioning routinely in the softgel shell among the present invention.
Red ginseng and lilyturf root soft capsule preparation method among the present invention is as follows:
Extracting method
1, thinly slice Radix Ginseng Rubra, Radix Ophiopogonis, add the alcohol heating reflux that 6-10 doubly measures 50-80% and extract 2 times, filter, filtrate recycling ethanol, crushed after being dried makes fine powder A.
2, thinly slice Radix Ginseng Rubra, Radix Ophiopogonis, add the alcohol heating reflux that 6-10 doubly measures 50-80% and extract 2 times, filter, filtrate recycling ethanol, medicinal residues decoct with water twice, each 2 hours, collecting decoction filters, and filtrate is concentrated in right amount, add equivalent ethanol, stir evenly, leave standstill, filter, filtrate recycling ethanol is concentrated into the clear paste that relative density is about 1.35 (80～85 ℃), add above-mentioned Radix Ginseng Rubra, Radix Ophiopogonis extract, mixing, crushed after being dried makes fine powder B.
3, Radix Ginseng Rubra is thinly sliced, and adds alcohol heating reflux and extracts, and filters, filtrate recycling ethanol, the five tastes such as medicinal residues and all the other Radix Ophiopogonis decoct with water twice, each 2 hours, collecting decoction filters, and filtrate is concentrated in right amount, add equivalent ethanol, stir evenly, leave standstill, filter, filtrate recycling ethanol is concentrated into the clear paste that relative density is about 1.35 (80～85 ℃), add above-mentioned red ginseng extract, mixing, crushed after being dried makes fine powder C.
The content preparation method:
1, appoints and get above-mentioned a kind of fine powder and be dispersed in and promptly get content in the ethylene glycol monomethyl ether;
2, the heating of surfactant and suspending agent is dissolved in the diluent, appoints and get above-mentioned a kind of fine powder and be dispersed in the diluent, cross the colloid mill mix homogeneously, promptly get content.
The capsule liquid making method:
Take by weighing in the pure water input glue jar, when rising to 70～80 ℃, temperature adds gelatin, glycerol, begin after pigment, titanium dioxide, the antiseptic to stir, keep 70～80 ℃ of temperature, vacuum outgas, vacuum outgas, vacuum outgas, vacuum outgas, vacuum outgas, stirred 1 hour, 55～60 ℃ of heat preservation for standby use.
Pelleting technology:
The medicinal liquid for preparing is carried out pelleting.Soft capsule moves into drying room and carries out drying 30 ± 5% times setting of 25 ± 2 ℃, relative humidity 20 hours, and drying condition is that 30 ± 2 ℃, relative humidity are 20%, 8 hours drying times.Exsiccant soft capsule washes ball, pack after picking up ball.
Beneficial effect of the present invention is embodied in following several respects:
(1) in soft capsule, content is the fine particles shape behind colloid mill, and is in uniform suspension state.Owing to the increase of specific surface area, improved the rate of release of medicine; If make uniform liquid, then after the soft capsule disintegrate, medicine is existed in gastric juice with molecularity, compare with hard capsule, can be absorbed more rapidly and fully by body, thereby improve drug bioavailability, reached the purpose that improves drug effect.
(2) capsule shells of making medicine behind the soft capsule and do not had breathability seals, and is isolated with air, is difficult for oxidation reaction takes place, and the active ingredient in the Chinese medicine is more stable.
(3) make the bitterness that can cover medicine behind the soft capsule, and good looking appearance, soft high resilience, swallow than hard capsule is easier, improved the compliance of patient's medication greatly.
The specific embodiment
Embodiment 1:
The content prescription:
Component: every weight (milligram) weight ratio (%)
Extract clear paste 90 20
PEG400 337.5 75
Tween 80 13.5 3
Cera Flava 92
Gross weight 450
The softgel shell prescription:
Component: weight (gram) weight ratio (%)
Gelatin 10,750 43
Glycerol 4,500 18
Water 8,878 38.1
Methyl hydroxybenzoate 20 0.08
Propylparaben 5 0.02
Iron oxide red 160 0.64
Titanium dioxide 25 0.1
Gross weight 25000
Content preparation technology is as follows:
Radix Ginseng Rubra is thinly sliced, and adds alcohol heating reflux and extracts, and filters, filtrate recycling ethanol, the five tastes such as medicinal residues and all the other Radix Ophiopogonis decoct with water twice, each 2 hours, collecting decoction filters, and filtrate is concentrated in right amount, add equivalent ethanol, stir evenly, leave standstill, filter, filtrate recycling ethanol is concentrated into the clear paste that relative density is about 1.35 (80～85 ℃), add above-mentioned red ginseng extract, mixing.The Cera Flava heating is dissolved among the PEG400, adds Tween 80, and above-mentioned clear paste evenly is dissolved in the diluent, make content.
The capsule liquid making method:
Take by weighing in the pure water input glue jar, add gelatin, glycerol when temperature rises to 70～80 ℃, begin after iron oxide red, titanium dioxide, the antiseptic to stir, keep 70～80 ℃ of temperature, vacuum outgas was stirred 1 hour, 55～60 ℃ of heat preservation for standby use.
Pelleting technology:
The medicinal liquid for preparing is carried out pelleting.Soft capsule moves into drying room and carries out drying 30 ± 5% times setting of 25 ± 2 ℃, relative humidity 20 hours, and drying condition is that 30 ± 2 ℃, relative humidity are 20%, 8 hours drying times.Exsiccant soft capsule washes ball, pack after picking up ball.
Embodiment 2:
The content prescription:
Component: every weight (milligram) weight ratio (%)
Concentrate clear paste 90 60
PEG400 45 30
PEG6000 3 2
Tween 80 7.5 5
Cera Flava 4.5 3
Gross weight 150
The softgel shell prescription:
Component: weight (gram) weight ratio (%)
Gelatin 11,250 45
Glycerol 5,500 22
Water 8,020 32
Methyl hydroxybenzoate 30 0.12
Propylparaben 7.5 0.03
Iron oxide red 160 0.64
Titanium dioxide 32. 0.13
Gross weight 25000
Extract preparation: the content preparation process is as follows: Radix Ginseng Rubra, Radix Ophiopogonis thinly slice, and add the alcohol heating reflux that 6-10 doubly measures 50-80% and extract 2 times, filter, and filtrate recycling ethanol, crushed after being dried makes fine powder.
The PEG6000 heating is dissolved among the PEG400, adds Tween 80, and fine powder is dispersed in the diluent, make content.
Preparation of capsule liquid and pelleting technology are with embodiment 1.
Embodiment 3:
The content prescription:
Component: every weight (milligram) weight ratio (%)
Extract fine powder 70 20
Soybean oil 238 68
Polyoxyethylene castor oil 28 8
Glyceryl monostearate 14 4
Gross weight 350
The softgel shell prescription:
Component: weight (gram) weight ratio (%)
Gelatin 11,750 47
Glycerol 6,750 27
Water 6,258 25
Ethyl hydroxybenzoate 36 0.144
Propylparaben 9 0.036
Iron oxide red 160 0.64
Titanium dioxide 37.5 0.15
Gross weight 25000
Content preparation technology is as follows:
Radix Ginseng Rubra, Radix Ophiopogonis thinly slice, and add the alcohol heating reflux that 6-10 doubly measures 50-80% and extract 2 times, filter, filtrate recycling ethanol, medicinal residues decoct with water twice, each 2 hours, collecting decoction filters, and filtrate is concentrated in right amount, add equivalent ethanol, stir evenly, leave standstill, filter, filtrate recycling ethanol is concentrated into the clear paste that relative density is about 1.35 (80～85 ℃), add above-mentioned Radix Ginseng Rubra, Radix Ophiopogonis extract, mixing, crushed after being dried makes fine powder.Polyoxyethylene castor oil and glyceryl monostearate heating are dissolved in the soybean oil, and the extract fine powder is dispersed in the above-mentioned diluent, make content.
Preparation of capsule liquid and pelleting technology are with embodiment 1.
Embodiment 4:
The content prescription:
Component: every weight (milligram) weight ratio (%)
Extract fine powder 70 50
Soybean oil 63 45
Polyoxyethylene castor oil 4.2 3
Glyceryl monostearate 2.8 2
Gross weight 140
The softgel shell prescription:
Component: weight (gram) weight ratio (%)
Gelatin 11,750 47
Glycerol 6,750 27
Water 6,258 25
Ethyl hydroxybenzoate 36 0.144
Propylparaben 9 0.036
Iron oxide red 160 0.64
Titanium dioxide 37.5 0.15
Gross weight 25000
Preparation is as embodiment 3.
Embodiment 5:
The content prescription:
Component: every weight (milligram) weight ratio (%)
Extract fine powder 70 15
Ethylene glycol monomethyl ether 397 85
Gross weight 467
The softgel shell prescription:
Component: weight (gram) weight ratio (%)
Gelatin 10,750 43
Glycerol 4,500 18
Water 8,878 38.1
Methyl hydroxybenzoate 20 0.08
Propylparaben 5 0.02
Iron oxide red 160 0.64
Titanium dioxide 25 0.1
Gross weight 25000
Content preparation technology is as follows:
Radix Ginseng Rubra is thinly sliced, and adds alcohol heating reflux and extracts, and filters, filtrate recycling ethanol, the five tastes such as medicinal residues and all the other Radix Ophiopogonis decoct with water twice, each 2 hours, collecting decoction filters, and filtrate is concentrated in right amount, add equivalent ethanol, stir evenly, leave standstill, filter, filtrate recycling ethanol is concentrated into the clear paste that relative density is about 1.35 (80～85 ℃), add above-mentioned red ginseng extract, mixing, crushed after being dried makes fine powder.Mixture is dissolved in the ethylene glycol monomethyl ether.
Preparation of capsule liquid and pelleting technology are with embodiment 1.
Claims (11)
1. the red ginseng and lilyturf root soft capsule of a YIN nourishing and the production of body fluid promoting, content comprise the extract and the pharmaceutic adjuvant of Radix Ginseng Rubra, Radix Ophiopogonis two flavor Chinese crude drugs at least, and wherein the weight proportion of various components is: extract 10-70%, pharmaceutic adjuvant 30-90%.
2. the red ginseng and lilyturf root soft capsule of a YIN nourishing and the production of body fluid promoting, content except that contain Radix Ginseng Rubra, Radix Ophiopogonis, also can select for use in Radix Adenophorae, Rhizoma Polygonati, Rhizoma Dioscoreae, seed of Fructus Lycii etc. the four flavor Chinese crude drugs a kind of or several, make extract and press column weight amount proportioning: extract 10-70%, pharmaceutic adjuvant 30-90% makes.
3. as claim 1,2 described red ginseng and lilyturf root soft capsules, it is characterized in that: described pharmaceutic adjuvant is an ethylene glycol monomethyl ether.
4. as claim 1,2 described red ginseng and lilyturf root soft capsules, it is characterized in that: described pharmaceutic adjuvant can be the combination of diluent, surfactant, suspending agent, and its weight proportion is 10-70: 30-80: 1-10: 1-5.
5. as claim 1,2 described red ginseng and lilyturf root soft capsules, it is characterized in that: described pharmaceutic adjuvant can be the combination of diluent, surfactant, suspending agent, and its weight proportion is preferably 15-60: 35-65: 3-8: 2-4.
6. as claim 4,5 described red ginseng and lilyturf root soft capsules, it is characterized in that: described diluent is one or more in Polyethylene Glycol (PEG) and the vegetable oil; Surfactant is one or more in tween, span, lecithin, the polyoxyethylene castor oil; Suspending agent is one or more in Cera Flava, ethyl cellulose, hydrogenated palm oil, the mono stearate glyceryl ester etc.
7. the preparation method of a red ginseng and lilyturf root soft capsule, the content preparation process is as follows: Radix Ginseng Rubra, Radix Ophiopogonis thinly slice, and add the alcohol heating reflux that 6-10 doubly measures 50-80% and extract 2 times, filter, filtrate recycling ethanol, crushed after being dried makes fine powder A.
8. the preparation method of a red ginseng and lilyturf root soft capsule, the content preparation process is as follows: Radix Ginseng Rubra, Radix Ophiopogonis thinly slice, add the alcohol heating reflux that 6-10 doubly measures 50-80% and extract 2 times, filter filtrate recycling ethanol, medicinal residues decoct with water twice, each 2 hours, collecting decoction filtered, filtrate is concentrated in right amount, add equivalent ethanol, stir evenly, leave standstill, filter, filtrate recycling ethanol is concentrated into the clear paste that relative density is about 1.35 (80～85 ℃), adds above-mentioned Radix Ginseng Rubra, Radix Ophiopogonis extract, mixing, crushed after being dried make fine powder B.
9. the preparation method of a red ginseng and lilyturf root soft capsule, the content preparation process is as follows: Radix Ginseng Rubra is thinly sliced, and adds alcohol heating reflux and extracts, and filters, filtrate recycling ethanol, the five tastes such as medicinal residues and all the other Radix Ophiopogonis decoct with water twice, each 2 hours, collecting decoction filters, and filtrate is concentrated in right amount, add equivalent ethanol, stir evenly, leave standstill, filter, filtrate recycling ethanol is concentrated into the clear paste that relative density is about 1.35 (80～85 ℃), add above-mentioned red ginseng extract, mixing, crushed after being dried makes fine powder C.
10. appoint and get above-mentioned a kind of fine powder and in ethylene glycol monomethyl ether, be uniformly dispersed and promptly get content M.
11. surfactant and/or suspending agent heating are dissolved in the diluent, and appoint and get above-mentioned a kind of fine powder, or be scattered in the dispersate, cross the colloid mill mix homogeneously; Or be dissolved in diluent, promptly get content N.Be raw material, prepared glue routinely with gelatin, glycerol, water again, will obtain the content fill then and make soft capsule, through typing, dry, wash ball, after promptly get product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510126088 CN1977944A (en) | 2005-11-30 | 2005-11-30 | Red ginseng and lilyturf root soft capsule and its preparing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510126088 CN1977944A (en) | 2005-11-30 | 2005-11-30 | Red ginseng and lilyturf root soft capsule and its preparing method |
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| CN1977944A true CN1977944A (en) | 2007-06-13 |
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| CN 200510126088 Pending CN1977944A (en) | 2005-11-30 | 2005-11-30 | Red ginseng and lilyturf root soft capsule and its preparing method |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103222526A (en) * | 2013-05-22 | 2013-07-31 | 北京绿源求证科技发展有限责任公司 | Food health preserving tea electuary for nourishing yin and moisturizing lung |
| CN105125816A (en) * | 2015-10-22 | 2015-12-09 | 陈远征 | Traditional Chinese medicine preparation for treating essential hypotension and preparation method thereof |
| WO2019047141A1 (en) * | 2017-09-08 | 2019-03-14 | 北京慧宝源生物技术股份有限公司 | Pharmaceutical composition for controlling blood sugar |
| CN110652590A (en) * | 2018-06-29 | 2020-01-07 | 上海复浩生物科技有限公司 | Traditional Chinese medicine compound for treating diabetes and preparation method and application thereof |
-
2005
- 2005-11-30 CN CN 200510126088 patent/CN1977944A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103222526A (en) * | 2013-05-22 | 2013-07-31 | 北京绿源求证科技发展有限责任公司 | Food health preserving tea electuary for nourishing yin and moisturizing lung |
| CN105125816A (en) * | 2015-10-22 | 2015-12-09 | 陈远征 | Traditional Chinese medicine preparation for treating essential hypotension and preparation method thereof |
| WO2019047141A1 (en) * | 2017-09-08 | 2019-03-14 | 北京慧宝源生物技术股份有限公司 | Pharmaceutical composition for controlling blood sugar |
| CN110300594A (en) * | 2017-09-08 | 2019-10-01 | 北京慧宝源生物技术股份有限公司 | Control the pharmaceutical composition of blood glucose |
| US11957726B2 (en) | 2017-09-08 | 2024-04-16 | Beijing Hebabiz Biotechnology Co., Inc. | Pharmaceutical composition for controlling blood sugar |
| CN110652590A (en) * | 2018-06-29 | 2020-01-07 | 上海复浩生物科技有限公司 | Traditional Chinese medicine compound for treating diabetes and preparation method and application thereof |
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