CN116268254A - Wild-imitation total ganoderma lucidum effervescent tablet with health care function and preparation method thereof - Google Patents
Wild-imitation total ganoderma lucidum effervescent tablet with health care function and preparation method thereof Download PDFInfo
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- 240000008397 Ganoderma lucidum Species 0.000 title claims abstract description 79
- 235000001637 Ganoderma lucidum Nutrition 0.000 title claims abstract description 79
- 239000007938 effervescent tablet Substances 0.000 title claims abstract description 43
- 230000036541 health Effects 0.000 title claims abstract description 34
- 238000002360 preparation method Methods 0.000 title claims abstract description 28
- 239000000843 powder Substances 0.000 claims abstract description 56
- 239000002253 acid Substances 0.000 claims abstract description 46
- 238000007873 sieving Methods 0.000 claims abstract description 41
- 241000222336 Ganoderma Species 0.000 claims abstract description 40
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 39
- 239000003513 alkali Substances 0.000 claims abstract description 37
- 239000000284 extract Substances 0.000 claims abstract description 35
- 238000005303 weighing Methods 0.000 claims abstract description 26
- 238000001035 drying Methods 0.000 claims abstract description 23
- 239000002994 raw material Substances 0.000 claims abstract description 21
- 238000000034 method Methods 0.000 claims abstract description 9
- 239000000853 adhesive Substances 0.000 claims abstract description 7
- 230000001070 adhesive effect Effects 0.000 claims abstract description 7
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 6
- 239000000945 filler Substances 0.000 claims abstract description 6
- 239000006184 cosolvent Substances 0.000 claims abstract description 5
- 238000004108 freeze drying Methods 0.000 claims abstract description 5
- 235000000346 sugar Nutrition 0.000 claims abstract description 5
- 238000001556 precipitation Methods 0.000 claims abstract description 3
- 238000003809 water extraction Methods 0.000 claims abstract description 3
- 239000008187 granular material Substances 0.000 claims description 58
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 51
- 239000004570 mortar (masonry) Substances 0.000 claims description 49
- 239000000463 material Substances 0.000 claims description 27
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 26
- 239000008101 lactose Substances 0.000 claims description 26
- 238000000227 grinding Methods 0.000 claims description 18
- 235000015165 citric acid Nutrition 0.000 claims description 17
- 238000002156 mixing Methods 0.000 claims description 16
- 238000010438 heat treatment Methods 0.000 claims description 14
- 239000002245 particle Substances 0.000 claims description 14
- 235000013399 edible fruits Nutrition 0.000 claims description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
- 235000019441 ethanol Nutrition 0.000 claims description 10
- 239000007788 liquid Substances 0.000 claims description 10
- 238000001816 cooling Methods 0.000 claims description 6
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- 238000001914 filtration Methods 0.000 claims description 6
- 238000003756 stirring Methods 0.000 claims description 6
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims description 4
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical group [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 4
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 claims description 4
- 238000012869 ethanol precipitation Methods 0.000 claims description 4
- 238000001704 evaporation Methods 0.000 claims description 4
- CDBYLPFSWZWCQE-UHFFFAOYSA-L sodium carbonate Substances [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 4
- 230000008569 process Effects 0.000 claims description 3
- 238000009461 vacuum packaging Methods 0.000 claims description 3
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 2
- 229920001353 Dextrin Polymers 0.000 claims description 2
- 239000004375 Dextrin Substances 0.000 claims description 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 2
- 229930195725 Mannitol Natural products 0.000 claims description 2
- 229920002472 Starch Polymers 0.000 claims description 2
- 229930006000 Sucrose Natural products 0.000 claims description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 2
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 2
- 239000001361 adipic acid Substances 0.000 claims description 2
- 235000011037 adipic acid Nutrition 0.000 claims description 2
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 2
- 238000009835 boiling Methods 0.000 claims description 2
- 235000019425 dextrin Nutrition 0.000 claims description 2
- 230000005496 eutectics Effects 0.000 claims description 2
- 238000007710 freezing Methods 0.000 claims description 2
- 230000008014 freezing Effects 0.000 claims description 2
- 239000001530 fumaric acid Substances 0.000 claims description 2
- 235000011087 fumaric acid Nutrition 0.000 claims description 2
- 238000003306 harvesting Methods 0.000 claims description 2
- 235000011090 malic acid Nutrition 0.000 claims description 2
- 239000001630 malic acid Substances 0.000 claims description 2
- 239000000594 mannitol Substances 0.000 claims description 2
- 235000010355 mannitol Nutrition 0.000 claims description 2
- 239000002244 precipitate Substances 0.000 claims description 2
- 230000001376 precipitating effect Effects 0.000 claims description 2
- 238000005057 refrigeration Methods 0.000 claims description 2
- 238000000926 separation method Methods 0.000 claims description 2
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 2
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- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 2
- 239000008107 starch Substances 0.000 claims description 2
- 235000019698 starch Nutrition 0.000 claims description 2
- 230000001954 sterilising effect Effects 0.000 claims description 2
- 239000005720 sucrose Substances 0.000 claims description 2
- 239000006228 supernatant Substances 0.000 claims description 2
- 235000002906 tartaric acid Nutrition 0.000 claims description 2
- 239000011975 tartaric acid Substances 0.000 claims description 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 2
- 239000008280 blood Substances 0.000 abstract description 5
- 210000004369 blood Anatomy 0.000 abstract description 5
- 239000003963 antioxidant agent Substances 0.000 abstract description 3
- 230000003078 antioxidant effect Effects 0.000 abstract description 3
- 230000004089 microcirculation Effects 0.000 abstract description 3
- 230000032683 aging Effects 0.000 abstract description 2
- 230000002708 enhancing effect Effects 0.000 abstract description 2
- 210000000987 immune system Anatomy 0.000 abstract description 2
- 210000004798 organs belonging to the digestive system Anatomy 0.000 abstract description 2
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 239000002671 adjuvant Substances 0.000 abstract 1
- 230000009286 beneficial effect Effects 0.000 abstract 1
- 201000011529 cardiovascular cancer Diseases 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 230000006870 function Effects 0.000 description 18
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 10
- 239000000047 product Substances 0.000 description 9
- 239000008118 PEG 6000 Substances 0.000 description 6
- 229920002584 Polyethylene Glycol 6000 Polymers 0.000 description 6
- 239000002585 base Substances 0.000 description 6
- 230000018109 developmental process Effects 0.000 description 5
- 229920001223 polyethylene glycol Polymers 0.000 description 5
- 238000005728 strengthening Methods 0.000 description 4
- 238000001514 detection method Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 230000000050 nutritive effect Effects 0.000 description 2
- 150000003254 radicals Chemical class 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 230000002000 scavenging effect Effects 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 208000019505 Deglutition disease Diseases 0.000 description 1
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- OIRDTQYFTABQOQ-UHFFFAOYSA-N ara-adenosine Natural products Nc1ncnc2n(cnc12)C1OC(CO)C(O)C1O OIRDTQYFTABQOQ-UHFFFAOYSA-N 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 238000004925 denaturation Methods 0.000 description 1
- 230000036425 denaturation Effects 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000007760 free radical scavenging Effects 0.000 description 1
- 210000004602 germ cell Anatomy 0.000 description 1
- 229910052732 germanium Inorganic materials 0.000 description 1
- GNPVGFCGXDBREM-UHFFFAOYSA-N germanium atom Chemical compound [Ge] GNPVGFCGXDBREM-UHFFFAOYSA-N 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000036449 good health Effects 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 230000008821 health effect Effects 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- 239000011669 selenium Substances 0.000 description 1
- 239000007909 solid dosage form Substances 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 230000004206 stomach function Effects 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 150000003648 triterpenes Chemical class 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/385—Concentrates of non-alcoholic beverages
- A23L2/39—Dry compositions
- A23L2/395—Dry compositions in a particular shape or form
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/40—Effervescence-generating compositions
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Medicines Containing Plant Substances (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The invention discloses a wild-simulated whole ganoderma lucidum effervescent tablet with a health care function and a preparation method thereof, belonging to the technical field of ganoderma lucidum processing. The wild-imitating full-glossy ganoderma effervescent tablet comprises the following components in parts by weight: 2-8 parts of wild-like full-glossy ganoderma powder, 20-30 parts of disintegrating agent, 58-64 parts of filler, 1-4 parts of cosolvent and 1-2 parts of adhesive. Sieving the above raw materials and adjuvants, weighing, granulating with acid and alkali, sieving, drying and granulating, and tabletting to obtain wild-like whole Ganoderma effervescent tablet. The wild-like total ganoderma lucidum effervescent tablet provided by the invention is beneficial to improving microcirculation of eaters, has an antioxidant function, can remove free radicals in vivo and resist aging, has a blood sugar reducing function, and can strengthen the operation of digestive organs; effectively enhancing the function of immune system, reducing the prevalence of cardiovascular diseases and tumors, and obtaining the ganoderma lucidum fruiting body extract by using a water extraction and alcohol precipitation method and a freeze drying technology, thereby effectively improving the utilization rate of ganoderma lucidum fruiting bodies after spore ejection.
Description
Technical Field
The invention relates to the technical field of ganoderma lucidum deep processing, in particular to a wild-simulated all-ganoderma lucidum effervescent tablet with a health care function and a preparation method thereof.
Background
Ganoderma lucidum is a traditional medicinal material for both food and medicine in China, has long history of medicinal use in China, is a rare medicinal material for strengthening body resistance and strengthening body resistance in China, and is listed as a top grade in Shennong Ben Cao Jing. Ganoderma spore is the extremely tiny oval germ cells ejected from Ganoderma pleat in the mature period of Ganoderma, i.e. Ganoderma seed, which coagulates the essence of Ganoderma, and has the whole health promoting effect of Ganoderma. The Ganoderma spore powder contains Ganoderma polysaccharide, ganoderma triterpene, natural organic germanium, folded adenine nucleoside, trace element selenium, etc., and has antioxidant and free radical scavenging effects; anti-inflammatory; pain relief; bacteriostasis; inhibiting tumor cells, etc. Wherein, ganoderan and ganoderan are main active ingredients, and modern medicine proves that ganoderan and ganoderan can improve microcirculation and reduce cholesterol; strengthening liver, spleen and intestine and stomach functions, and strengthening the operation of digestive organs; enhancing the functioning of the immune system; accelerating blood microcirculation, improving oxygen supply capability of blood, etc. Along with the enhancement of health care consciousness of people, the demand of the domestic and foreign markets for ganoderma lucidum is gradually increased, and ganoderma lucidum products have good development and application prospects in the field of large health.
The ganoderma lucidum product is mostly packaged by an aluminum foil bag or a ceramic pot and is taken by being matched with warm water, so that the loss of the wall hanging of spore powder is easy to cause, and the ganoderma lucidum product is inconvenient to carry and eat. In addition, after the ganoderma lucidum ejects spore powder, a great amount of active ingredients are lost, so that the market value of fruiting bodies after spore ejection is generally underestimated.
The Chinese medicine oral effervescent tablet is a novel solid dosage form, and has the advantages of convenient administration and quick response; good taste and good compliance of users; the bioavailability is high; the traditional Chinese medicine oral effervescent tablet is more and more favored by patients because of the advantages of convenient carrying, transportation, storage and the like.
The wild-imitating ganoderma lucidum full ganoderma lucidum spore powder effervescent tablet is developed at present to meet the requirements of consumers on ganoderma lucidum health care products which are convenient to carry and good in health care effect.
Disclosure of Invention
The invention aims to provide a wild-simulated whole ganoderma lucidum effervescent tablet with a health care function and a preparation method thereof. According to the wild-like whole ganoderma lucidum effervescent tablet, the freeze-drying technology is used for obtaining the extract of fruiting bodies after spore ejection and ganoderma lucidum spore powder to form the raw materials of the wild-like whole ganoderma lucidum, the wild-like whole ganoderma lucidum effervescent tablet is prepared by an acid-base separate granulation method, the raw materials of the effervescent tablet are processed by the wild-like whole ganoderma lucidum, the wild-like whole ganoderma lucidum effervescent tablet is easy to store, transport, store and carry, the compliance of users is good, the nutritive value is high, the bioavailability of ganoderma lucidum can be improved, the idea of healthy development is met, and the wild-like whole ganoderma lucidum effervescent tablet has good development and application prospects in the field of great health, and the technical scheme adopted by the invention is as follows:
according to one aspect of the invention, the invention provides an imitation wild ganoderma lucidum effervescent tablet with a health care function, which comprises the following components in parts by weight: 2-8 parts of wild-like whole ganoderma lucidum powder, 20-30 parts of disintegrating agent, 58-64 parts of filler, 1-4 parts of cosolvent and 1-2 parts of adhesive.
Preferably, the wild-like whole ganoderma lucidum powder comprises ganoderma lucidum spore powder and a fruiting body extract after spore ejection, wherein the ganoderma lucidum spore powder is prepared by the following steps of: the ratio of fruiting body extract is 1:3.
Preferably, the preparation steps of the spore powder are as follows: harvesting spores of ganoderma lucidum, sieving the spores with a 100-mesh sieve, sterilizing the sieved spores in a wet and hot environment at 100 ℃, then drying the spores at low temperature by a low-temperature oven, breaking the wall of the dried spores for 45min by using a cell-grade superfine pulverizer at the low temperature of 10-15 ℃ to obtain ganoderma lucidum spore powder, sieving the ganoderma lucidum spore powder after breaking the wall with a 300-mesh sieve, and vacuum packaging for later use.
Preferably, the preparation steps of the fruit body extract are as follows: drying Ganoderma fruiting body, sieving with 40 mesh sieve to obtain coarse powder, extracting with water, precipitating with ethanol, centrifuging, evaporating, and lyophilizing to obtain extract.
Preferably, the steps of water extraction and alcohol precipitation are as follows: weighing 50g of fruit body coarse powder, adding 200mL of water, heating to boiling, stirring and heating for 3h, keeping the liquid level unchanged, filtering, collecting filter residues, extracting again under the same condition, mixing the two water extracts, heating, continuously stirring to obtain concentrated extract, and cooling the extract to room temperature or lower; slowly adding ethanol into the concentrated extract under the condition of strong stirring to ensure that the ethanol content reaches 80 percent, generating flocculent precipitate during the process, slowly cooling the ethanol-containing liquid medicine to room temperature, transferring to a refrigeration house, standing for 24-48 hours at 5-10 ℃, taking supernatant liquid for centrifugal separation, filtering the centrifuged ethanol precipitation liquid, and rotationally evaporating the ethanol precipitation liquid after filtering to obtain concentrated extract.
Preferably, the freeze-drying method comprises the following steps: the obtained concentrated extracting solution is put into a freezing chamber for prefreezing, the prefreezing temperature is set at minus 35 ℃, the eutectic point of the extracting solution is reached, the prefreezing time is 15 hours, the prefreezed extracting solution is sent into a drying bin, a vacuum pump is started, the vacuum pressure is kept below 10pa, the temperature is slowly increased to minus 15 ℃ at the heating rate of 1 ℃ per hour, the temperature is kept for 10 hours, the temperature is slowly increased to minus 5 ℃ at the heating rate of 2 ℃ per hour, the temperature is kept for 5 hours, and the first drying stage is finished; slowly heating to 40deg.C at a heating rate of 3 deg.C per hour, maintaining the temperature for 6 hr, taking out to obtain Ganoderma fruiting body extract, bagging, and vacuum-cooling to obtain Ganoderma fruiting body extract bag.
Preferably, the disintegrating agent is an acid source and an alkali source, and the acid source is one of citric acid, tartaric acid, fumaric acid, adipic acid and malic acid; the alkali source is sodium bicarbonate or sodium carbonate.
Preferably, the filler is one of lactose, starch, powdered sugar, dextrin, mannitol and sucrose.
Preferably, the binder is one of absolute ethanol, water, PVP and L-HPC.
Preferably, the cosolvent is PEG 6000.
Preferably, the preparation method of the wild-simulated whole ganoderma lucidum effervescent tablet with the health care function comprises the following steps of:
(1) Sieving raw materials: grinding wild-like Ganoderma powder in a mortar at 25deg.C or below and humidity of 30% or below until the powder is 100 mesh;
(2) Sieving auxiliary materials: grinding all auxiliary materials in a mortar at a temperature of not higher than 25 ℃ and a humidity of not higher than 30% until the auxiliary materials are sieved by a 100-mesh sieve;
(3) Weighing raw materials and auxiliary materials: weighing the raw materials and the auxiliary materials according to a proportion;
(4) Granulating: taking two mortars to prepare acid particles and alkali particles separately, and adding half of wild-like total ganoderma lucidum powder into the two mortars according to groups; weighing lactose according to half of the weight of the group in a mortar for preparing alkali granules, and grinding uniformly; weighing lactose according to half of the weight of the groups in a mortar for preparing acid granules, and grinding uniformly;
(5) Sieving: adding a proper amount of adhesive according to the conditions of acid particles and alkali particles, and sieving with a 16-mesh sieve to obtain granules;
(6) Drying and granulating: drying in a 50 ℃ oven for 1.5 hours, adding acid sources correspondingly in a mortar for preparing acid particles according to a grouping proportion, and mixing uniformly, and finally mixing the acid particles and the alkali particles uniformly;
(7) Tabletting: tabletting the well-granulated acid and alkali granules.
The technical scheme adopted by the invention has the following remarkable effects:
(1) The wild-like total ganoderma lucidum effervescent tablet is reasonable in proportion, the product is added into 200mL of water, and after the product is disintegrated in the water, the product is drunk, has good health-care functions of improving the antioxidant capacity, scavenging free radicals, resisting aging, reducing blood sugar and the like, and the raw materials of the formula are edible products, so that the eating is safe; the preparation process is simple, and the finished product is easy to preserve and eat. The quality difference detection, the disintegration time limit detection and the hardness detection are all in the national standard range, the ganoderma lucidum fruit body extract after spore ejection is effectively utilized, the utilization value of the ganoderma lucidum fruit body extract is improved, the ganoderma lucidum fruit body extract is convenient to store, transport, store and carry, the industrial production is convenient, the compliance of users is good, the nutrition value is high, the bioavailability of ganoderma lucidum can be improved, the idea of healthy development is met, and the ganoderma lucidum fruit body extract has good development and application prospects in the field of great health and is worthy of popularization and production.
(2) According to the invention, the ganoderma lucidum fruiting body is extracted by a freeze drying technology to obtain the ganoderma lucidum fruiting body extract, so that the activity of the extracted ganoderma lucidum is protected to the greatest extent, and meanwhile, the oxidative denaturation of the ganoderma lucidum fruiting body extract in the storage and transportation process is prevented to the greatest extent by vacuum packaging.
(3) The wild-like total ganoderma effervescent tablet has simple preparation process, convenient taking and quick response; the compliance of the users is good, and the capsule is suitable for the old, children and people with dysphagia to take; the effervescent tablet is convenient to store, transport, store and carry, has good health care functions of resisting oxidation, scavenging free radicals, reducing blood sugar and the like, has higher nutritive value, and can improve the bioavailability of ganoderma lucidum.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention will be described in further detail by referring to preferred embodiments. It should be noted, however, that many of the details set forth in the description are merely provided to provide a thorough understanding of one or more aspects of the invention, and that these aspects of the invention may be practiced without these specific details.
The invention relates to a wild-simulated whole ganoderma lucidum effervescent tablet with a health care function and a preparation method thereof, wherein the wild-simulated whole ganoderma lucidum effervescent tablet comprises the following raw materials in parts by weight: 2-8 parts of wild-like full-glossy ganoderma powder, wherein the disintegrating agent is an acid source and an alkali source, 15 parts of the acid source, 15 parts of the alkali source, 58-64 parts of filler, 4 parts of cosolvent and 1mL of adhesive.
Example 1:
a preparation method of wild-like full-glossy ganoderma effervescent tablet with health care function comprises the following components in parts by mass: 2 parts of wild-like whole ganoderma lucidum powder, 0.5 part of spore powder and 1.5 parts of fruiting body extract; 15 parts of citric acid, 15 parts of sodium bicarbonate, 64 parts of lactose, 60004 parts of PEG and 1mL of absolute ethyl alcohol.
The preparation method of the wild-like total ganoderma lucidum effervescent tablet with the health care function comprises the following steps:
step one: sieving raw materials: grinding wild-like Ganoderma powder with mortar at 25deg.C or below and humidity of 30% or below, and sieving with 100 mesh sieve.
Step two: sieving auxiliary materials: all auxiliary materials are ground by a mortar to pass through a 100-mesh sieve in an environment with the temperature not higher than 25 ℃ and the humidity not higher than 30%.
Step three: weighing raw materials and auxiliary materials: weighing wild-like whole ganoderma powder, citric acid, sodium bicarbonate, lactose and PEG 6000 according to a certain proportion.
Step four: granulating: (1) Taking two mortars to prepare acid granules and alkali granules separately, and adding half of wild-like total ganoderma lucidum powder into the two mortars according to groups. (2) Weighing lactose according to half of the weight of the group in a mortar for preparing alkali granules, and grinding uniformly; the lactose is weighed and ground into a mortar for preparing the acid granules according to half of the weight of the group.
Step five: sieving: adding appropriate amount of about 0.2mL absolute ethanol according to the conditions of acid granule and alkali granule, sieving with 16 mesh sieve, and grading
Step six: drying and granulating: drying in oven at 50deg.C for 1.5 hr, adding citric acid in mortar for preparing acid granule, mixing, and mixing acid granule and alkali granule
Step seven: tabletting: tabletting the acid-base granules after finishing.
Example 2:
a preparation method of wild-like full-glossy ganoderma effervescent tablet with health care function comprises the following components in parts by mass: 4 parts of wild-like whole ganoderma lucidum powder, 1 part of spore powder and 3 parts of fruiting body extract; 15 parts of citric acid, 15 parts of sodium bicarbonate, 62 parts of lactose, 60004 parts of PEG and 1mL of absolute ethyl alcohol.
A preparation method of wild-like full-glossy ganoderma effervescent tablet with health care function comprises the following steps:
step one: sieving raw materials: grinding wild-like Ganoderma powder with mortar at 25deg.C or below and humidity of 30% or below, and sieving with 100 mesh sieve.
Step two: sieving auxiliary materials: all auxiliary materials are ground by a mortar to pass through a 100-mesh sieve in an environment with the temperature not higher than 25 ℃ and the humidity not higher than 30%.
Step three: weighing raw materials and auxiliary materials: weighing wild-like whole ganoderma powder, citric acid, sodium bicarbonate, lactose and PEG 6000 according to a certain proportion.
Step four: granulating: (1) Taking two mortars to prepare acid granules and alkali granules separately, and adding half of wild-like total ganoderma lucidum powder into the two mortars according to groups. (2) Weighing lactose according to half of the weight of the group in a mortar for preparing alkali granules, and grinding uniformly; the lactose is weighed and ground into a mortar for preparing the acid granules according to half of the weight of the group.
Step five: sieving: adding appropriate amount of about 0.2mL absolute ethanol according to the conditions of acid granule and alkali granule, sieving with 16 mesh sieve, and grading
Step six: drying and granulating: drying in oven at 50deg.C for 1.5 hr, adding citric acid in mortar for preparing acid granule, mixing, and mixing acid granule and alkali granule
Step seven: tabletting: tabletting the acid-base granules after finishing.
Example 3:
a preparation method of wild-like full-glossy ganoderma effervescent tablet with health care function comprises the following components in parts by mass: 8 parts of wild-like whole ganoderma lucidum powder, 2 parts of spore powder, 6 parts of fruit body extract, 15 parts of citric acid, 15 parts of sodium bicarbonate, 58 parts of lactose, 60004 parts of PEG and 1mL of absolute ethyl alcohol.
The preparation method of the wild-like total ganoderma lucidum effervescent tablet with the health care function comprises the following steps:
step one: sieving raw materials: grinding wild-like Ganoderma powder with mortar at 25deg.C or below and humidity of 30% or below, and sieving with 100 mesh sieve.
Step two: sieving auxiliary materials: all auxiliary materials are ground by a mortar to pass through a 100-mesh sieve in an environment with the temperature not higher than 25 ℃ and the humidity not higher than 30%.
Step three: weighing raw materials and auxiliary materials: weighing wild-like whole ganoderma powder, citric acid, sodium bicarbonate, lactose and PEG 6000 according to a certain proportion.
Step four: granulating: (1) Taking two mortars to prepare acid granules and alkali granules separately, and adding half of wild-like total ganoderma lucidum powder into the two mortars according to groups. (2) Weighing lactose according to half of the weight of the group in a mortar for preparing alkali granules, and grinding uniformly; the lactose is weighed and ground into a mortar for preparing the acid granules according to half of the weight of the group.
Step five: sieving: adding appropriate amount of about 0.2mL absolute ethanol according to the conditions of acid granule and alkali granule, sieving with 16 mesh sieve, and grading
Step six: drying and granulating: drying in oven at 50deg.C for 1.5 hr, adding citric acid in mortar for preparing acid granule, mixing, and mixing acid granule and alkali granule
Step seven: tabletting: tabletting the acid-base granules after finishing.
Example 4:
a preparation method of wild-like full-glossy ganoderma effervescent tablet with health care function comprises the following components in parts by mass: 16 parts of wild-like whole ganoderma lucidum powder, 4 parts of spore powder, 12 parts of fruit body extract, 15 parts of citric acid, 15 parts of sodium bicarbonate, 50 parts of lactose, 60004 parts of PEG and 1mL of absolute ethyl alcohol.
The preparation method of the wild-like total ganoderma lucidum effervescent tablet with the health care function comprises the following steps:
step one: sieving raw materials: grinding wild-like Ganoderma powder with mortar at 25deg.C or below and humidity of 30% or below, and sieving with 100 mesh sieve.
Step two: sieving auxiliary materials: all auxiliary materials are ground by a mortar to pass through a 100-mesh sieve in an environment with the temperature not higher than 25 ℃ and the humidity not higher than 30%.
Step three: weighing raw materials and auxiliary materials: weighing wild-like whole ganoderma powder, citric acid, sodium bicarbonate, lactose and PEG 6000 according to a certain proportion.
Step four: granulating: (1) Taking two mortars to prepare acid granules and alkali granules separately, and adding half of wild-like total ganoderma lucidum powder into the two mortars according to groups. (2) Weighing lactose according to half of the weight of the group in a mortar for preparing alkali granules, and grinding uniformly; the lactose is weighed and ground into a mortar for preparing the acid granules according to half of the weight of the group.
Step five: sieving: adding appropriate amount of about 0.2mL absolute ethanol according to the conditions of acid granule and alkali granule, sieving with 16 mesh sieve, and grading
Step six: drying and granulating: drying in oven at 50deg.C for 1.5 hr, adding citric acid in mortar for preparing acid granule, mixing, and mixing acid granule and alkali granule
Step seven: tabletting: tabletting the acid-base granules after finishing.
Example 5:
a preparation method of wild-like full-glossy ganoderma effervescent tablet with health care function comprises the following components in parts by mass: 24 parts of wild-like whole ganoderma lucidum powder, 6 parts of spore powder, 18 parts of fruit body extract, 15 parts of citric acid, 15 parts of sodium bicarbonate, 42 parts of lactose, 60004 parts of PEG and 1mL of absolute ethyl alcohol.
A preparation method of wild-like full-glossy ganoderma effervescent tablet with health care function comprises the following steps:
step one: sieving raw materials: grinding wild-like Ganoderma powder with mortar at 25deg.C or below and humidity of 30% or below, and sieving with 100 mesh sieve.
Step two: sieving auxiliary materials: all auxiliary materials are ground by a mortar to pass through a 100-mesh sieve in an environment with the temperature not higher than 25 ℃ and the humidity not higher than 30%.
Step three: weighing raw materials and auxiliary materials: weighing wild-like whole ganoderma powder, citric acid, sodium bicarbonate, lactose and PEG 6000 according to a certain proportion.
Step four: granulating: (1) Taking two mortars to prepare acid granules and alkali granules separately, and adding half of wild-like total ganoderma lucidum powder into the two mortars according to groups. (2) Weighing lactose according to half of the weight of the group in a mortar for preparing alkali granules, and grinding uniformly; the lactose is weighed and ground into a mortar for preparing the acid granules according to half of the weight of the group.
Step five: sieving: adding appropriate amount of about 0.2mL absolute ethanol according to the conditions of acid granule and alkali granule, sieving with 16 mesh sieve, and grading
Step six: drying and granulating: drying in oven at 50deg.C for 1.5 hr, adding citric acid in mortar for preparing acid granule, mixing, and mixing acid granule and alkali granule
Step seven: tabletting: tabletting the acid-base granules after finishing.
The foregoing is merely a preferred embodiment of the present invention and it should be noted that modifications and adaptations to those skilled in the art may be made without departing from the principles of the present invention, which are intended to be comprehended within the scope of the present invention.
Claims (10)
1. A wild-like full-glossy ganoderma effervescent tablet with health care function is characterized in that: comprises the following components in parts by weight: 2-8 parts of wild-like whole ganoderma lucidum powder, 20-30 parts of disintegrating agent, 58-64 parts of filler, 1-4 parts of cosolvent and 1-2 parts of adhesive.
2. The wild-like whole ganoderma lucidum effervescent tablet with health care function according to claim 1, which is characterized in that: the wild-like whole ganoderma lucidum powder comprises ganoderma lucidum spore powder and fruiting body extract after spore ejection, wherein the ganoderma lucidum spore powder is prepared by the steps of: the ratio of fruiting body extract is 1:3.
3. The wild-like whole ganoderma lucidum effervescent tablet with health care function according to claim 2, which is characterized in that: the preparation method of the spore powder comprises the following steps: harvesting spores of ganoderma lucidum, sieving the spores with a 100-mesh sieve, sterilizing the sieved spores in a damp-heat environment at 100 ℃, then drying the spores at low temperature by using a low-temperature oven, breaking the wall of the dried spores for 45min by using a cell-grade superfine pulverizer at the low temperature of 10-15 ℃ to obtain ganoderma lucidum spore powder, sieving the ganoderma lucidum spore powder after breaking the wall with a 300-mesh sieve, and vacuum packaging for later use.
4. The wild-like whole ganoderma lucidum effervescent tablet with health care function according to claim 2, which is characterized in that: the preparation method of the fruit body extract comprises the following steps: drying Ganoderma fruiting body, sieving with 40 mesh sieve to obtain coarse powder, extracting with water, precipitating with ethanol, centrifuging, evaporating, and lyophilizing to obtain extract.
5. The wild-like whole ganoderma lucidum effervescent tablet with health care function and the preparation method thereof are characterized in that: the water extraction and alcohol precipitation steps are as follows: weighing 50g of fruit body coarse powder, adding 200mL of water, heating to boiling, stirring and heating for 3h, keeping the liquid level unchanged, filtering, collecting filter residues, extracting again under the same condition, mixing the two water extracts, heating, continuously stirring to obtain concentrated extract, and cooling the extract to room temperature or lower; slowly adding ethanol into the concentrated extract under the condition of strong stirring to ensure that the ethanol content reaches 80 percent, generating flocculent precipitate during the process, slowly cooling the ethanol-containing liquid medicine to room temperature, transferring to a refrigeration house, standing for 24-48 hours at 5-10 ℃, taking supernatant liquid for centrifugal separation, filtering the centrifuged ethanol precipitation liquid, and rotationally evaporating the ethanol precipitation liquid after filtering to obtain concentrated extract.
6. The wild-like whole ganoderma lucidum effervescent tablet with health care function and the preparation method thereof are characterized in that: the freeze-drying method comprises the following steps: the obtained concentrated extracting solution is put into a freezing chamber for prefreezing, the prefreezing temperature is set at minus 35 ℃, the eutectic point of the extracting solution is reached, the prefreezing time is 15 hours, the prefreezed extracting solution is sent into a drying bin, a vacuum pump is started, the vacuum pressure is kept below 10pa, the temperature is slowly increased to minus 15 ℃ at the heating rate of 1 ℃ per hour, the temperature is kept for 10 hours, the temperature is slowly increased to minus 5 ℃ at the heating rate of 2 ℃ per hour, the temperature is kept for 5 hours, and the first drying stage is finished; slowly heating to 40deg.C at a heating rate of 3deg.C per hour, maintaining the temperature for 6 hr, taking out to obtain Ganoderma fruiting body extract, bagging, and vacuum-cooling to obtain Ganoderma fruiting body extract.
7. The wild-like whole ganoderma lucidum effervescent tablet with health care function and the preparation method thereof are characterized in that: the disintegrating agent is an acid source and an alkali source, and the acid source is one of citric acid, tartaric acid, fumaric acid, adipic acid and malic acid; the alkali source is sodium bicarbonate or sodium carbonate.
8. The wild-like whole ganoderma lucidum effervescent tablet with health care function and the preparation method thereof are characterized in that: the filler is one of lactose, starch, powdered sugar, dextrin, mannitol and sucrose.
9. The wild-like whole ganoderma lucidum effervescent tablet with health care function and the preparation method thereof are characterized in that: the adhesive is one of absolute ethyl alcohol, water, PVP and L-HPC.
10. A method for preparing the wild-like whole ganoderma lucidum effervescent tablet with health care function according to any one of claims 1 to 9, which is characterized in that: the method comprises the following steps:
(1) Sieving raw materials: grinding wild-like Ganoderma powder in a mortar at 25deg.C or below and humidity of 30% or below until the powder is 100 mesh;
(2) Sieving auxiliary materials: grinding all auxiliary materials in a mortar at a temperature of not higher than 25 ℃ and a humidity of not higher than 30% until the auxiliary materials are sieved by a 100-mesh sieve;
(3) Weighing raw materials and auxiliary materials: weighing the raw materials and the auxiliary materials according to a proportion;
(4) Granulating: taking two mortars to prepare acid particles and alkali particles separately, and adding half of wild-like total ganoderma lucidum powder into the two mortars according to groups; weighing lactose according to half of the weight of the group in a mortar for preparing alkali granules, and grinding uniformly; weighing lactose according to half of the weight of the groups in a mortar for preparing acid granules, and grinding uniformly;
(5) Sieving: adding a proper amount of adhesive according to the conditions of acid particles and alkali particles, and sieving with a 16-mesh sieve to obtain granules;
(6) Drying and granulating: drying in a 50 ℃ oven for 1.5 hours, adding acid sources correspondingly in a mortar for preparing acid particles according to a grouping proportion, and mixing uniformly, and finally mixing the acid particles and the alkali particles uniformly;
(7) Tabletting: tabletting the well-granulated acid and alkali granules.
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