CN104055963B - A kind of fat reducing Chinese medicine composition and preparation method - Google Patents
A kind of fat reducing Chinese medicine composition and preparation method Download PDFInfo
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- CN104055963B CN104055963B CN201310615473.8A CN201310615473A CN104055963B CN 104055963 B CN104055963 B CN 104055963B CN 201310615473 A CN201310615473 A CN 201310615473A CN 104055963 B CN104055963 B CN 104055963B
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Abstract
The invention discloses a kind of fat reducing Chinese medicine compositions, including following weight percents component：Lotus leaf 3%~79%, rhizoma alismatis 5%~75%, Ilex Latifolia Thunb 4%~70%, cassia seed 2%~78%, rheum officinale 4%~45%, dried orange peel 6%~60%.The invention also discloses a kind of preparation method of above-mentioned Chinese medicine composition, including effective constituents extraction, according to formula it is prepared into finished product.The Chinese medicine composition of the present invention makes full use of bulk pharmaceutical chemicals to carry out scientific matching, generates coordinating effect, reduces fat, and more traditional preparation has more preferable curative effect, and quality is more controllable, is suitble to industrialized production.
Description
Technical field
The present invention relates to a kind of fat reducing Chinese medicine composition and preparation methods, belong to the field of Chinese medicines.
Background technology
With the continuous improvement of people's living standards, the change of dietary structure, aging of population become clear day by day, it is cardiopathic
Incidence increasingly rises.For the whole world, since half a century, heart disease has become the disease for threatening human health most serious
One of, it is the underlying cause of death in the U.S. and certain industrialized countries.According to the statistics of the World Health Organization, in the total death toll in the U.S., have
24.7% dies of coronary heart disease, and Northern Ireland coronary heart disease case fatality rate occupies first place in the world, and is 5,36/,100,000；Japan is minimum, is 41/,100,000.
In recent years, the morbidity and mortality of China's coronary heart disease persistently rise, and have more than 700,000 people every year at present and die of coronary heart disease, in being
The elderly's the most common type cardiovascular disease has leapt to as first of internal disease.It can be seen that coronary heart disease has become global public hazards,
American wins worry as " pestilence in epoch ".
Obesity is to lead to all kinds of chronic diseases, such as an important risk factor of hyperlipidemia, hypertension and diabetes.High blood
Fat disease can also result in fatty liver, hepatic sclerosis, cholelithiasis, pancreatitis, fundus hemorrhage, blindness, peripheral vascular disease, limping, high urine
Acidaemia.So fat harm, positive prevention and treatment must be paid much attention to.
The means of clinical treatment obesity include liposuction, kinesiatrics and take slimming medicine at present.But some patientss
Since physical condition is poor, kinesiatrics can not be taken.Lipsuction risk is larger, and some patientss repel operation method.Therefore, it carries
Drug is extracted for a kind of safely controllable, cheap, eutherapeutic pure plant, there is great social effect and economic valence
Value.
Invention content
The object of the present invention is to provide the more controllable fat reducing Chinese medicine compositions of a kind of good effect, quality.
It is a further object of the present invention to provide a kind of preparation methods of the Chinese medicine composition.
It is a further object of the present invention to provide a kind of in the Chinese medicine composition equally in price with the market competitiveness.Institute
The Chinese medicine composition stated will not increase the financial burden of patient because of the raising of curative effect.
The present invention is made of following raw material：
Lotus leaf, cassia seed, rhizoma alismatis（Alismataceae）, Ilex Latifolia Thunb, rheum officinale, dried orange peel；The preferred great Ye of the Ilex Latifolia Thunb
Ilex kudingcha C.J.Tseng.
In order to achieve the above objectives, in drug composition of the invention, including following weight percents component：
Lotus leaf 3%~79%, rhizoma alismatis 5%~75%, Ilex Latifolia Thunb 4%~70%, cassia seed 2%~78%, rheum officinale 4%~45%, dried orange peel
6%~60%；
Preferably, in Chinese medicine composition of the present invention, including following weight percents component：
Lotus leaf 10%~55%, rhizoma alismatis 8%~50%, Ilex Latifolia Thunb 10%~40%, cassia seed 5%~50%, rheum officinale 10%~35% are old
Skin 10%~50%；
It is furthermore preferred that in Chinese medicine composition of the present invention, including following weight percents component：
Lotus leaf 10%~40%, rhizoma alismatis 10%~25%, Ilex Latifolia Thunb 10%~30%, cassia seed 10%~30%, rheum officinale 10%~25%,
Dried orange peel 10%~35%；
It is further preferred that in Chinese medicine composition of the present invention, including following weight percents component：
Lotus leaf 25%, rhizoma alismatis 13%, Ilex Latifolia Thunb 15%, cassia seed 20%, rheum officinale 12%, dried orange peel 15%.
The sum of weight percent of each raw material is 100%.
Composition of the present invention, can each bulk pharmaceutical chemicals be respectively adopted following methods extraction, then extract is mixed again
Conjunction：
Raw material is taken, ethyl acetate and ethyl alcohol, heating and refluxing extraction are added after being crushed, obtains extracting solution I, second is added in the dregs of a decoction
Alcohol, heating and refluxing extraction obtain extracting solution II, merge extracting solution I and II, are condensed into medicinal extract, medicinal extract are dissolved with ethyl alcohol, using non-pole
Property or low pole macroreticular resin detach it, first with 65%~70% ethanol elution, obtain eluent I；Then with 85%~
90% ethanol elution obtains eluent II, recycles, and is concentrated under reduced pressure, it is dry to get.
Preferably, the volume ratio of the ethyl acetate and ethyl alcohol is 1:2.
Preferably, the volumetric concentration of elution ethyl alcohol is 65% for the first time；The volumetric concentration of second of elution ethyl alcohol is 90%.
It is furthermore preferred that the preparation method of the Chinese medicine composition of the present invention includes the following steps：
Raw material is taken, volume ratio 1 is added after being crushed:2 ethyl acetate and 70% ethyl alcohol, heating and refluxing extraction 2 times, the
One time 1~3 hour, second 1~2 hour, filtrate merged to obtain extracting solution I, and 70% ethyl alcohol, heating and refluxing extraction 2 is added in the dregs of a decoction
Secondary, 0.5~1.5 hour for the first time, second 0.5~1 hour, filtrate merged to obtain extracting solution II, merged extracting solution I and II, dense
It shortens medicinal extract into, dissolves medicinal extract with 50% ethyl alcohol, it is detached using nonpolarity or low pole macroreticular resin, first 65%~
70% ethanol elution obtains eluent I；Again with 85%~90% ethanol elution, eluent II is obtained, is recycled, is concentrated under reduced pressure, it is dry, i.e.,
.
The elution flow rate is 1~4BV/h；Preferably, elution flow rate is 1~2BV/h, more preferably 2BV/h.
The macroreticular resin is preferably AB-8 and X-5, more preferably X-5.
Heretofore described concentration of alcohol is volumetric concentration.
Preferably, cassia seed, rheum officinale and dried orange peel bulk pharmaceutical chemicals are prepared into extract using the above method, then again by its with
Lotus leaf, rhizoma alismatis and the Folum Ilicis extract mixing prepared by following methods can be prepared into composition of the present invention.
Lotus leaf, rhizoma alismatis and Folum Ilicis extract preparation method of the present invention include：
（1）By raw material extracting in water 2 times, 6~10 times of amount water, 90 DEG C~100 DEG C holding 1.5-3 of temperature are added for the first time
Hour, filtering；Second of addition, 4~8 times of amount water, 90 DEG C~100 DEG C of temperature are kept for 0.5~1.5 hour, filtering, merging filtrate；
（2）Macroporous absorbent resin on filtrate, respectively for the second time with the elution for the first time of 20%~60% ethyl alcohol, 60%~95% ethyl alcohol
Eluent is collected in elution；
（3）0.01~0.09Mpa of steam pressure, vacuum degree -0.03~-0.08Mpa, 50~85 DEG C of temperature are concentrated into phase
To 1.20~1.25g/cm of density3Medicinal extract（50~55 DEG C of surveys）；
（4）Vacuum degree -0.04~-0.09Mpa, 60~95 DEG C of temperature, dry, pulverize 60 mesh sieve to get.
Preferably, step（2）Middle ethanol eluate volumetric concentration is respectively：For the first time 30%~55%；Second 70%~
80%；It is furthermore preferred that the volumetric concentration of elution ethyl alcohol is respectively：For the first time 35%；Second 75%.
Preferably, step（3）Middle 0.04~0.07Mpa of steam pressure, vacuum degree -0.04~-0.06Mpa, temperature 65~
75 DEG C, it is concentrated into 1.20~1.25g/cm of relative density3Medicinal extract.
It is furthermore preferred that step（3）Middle steam pressure 0.05Mpa, vacuum degree -0.06Mpa, temperature 70 C are concentrated into opposite
Density 1.23g/cm3Medicinal extract.
The composition of the present invention, can be with such as starch, dextrin, lactose, micro- of auxiliary material in any type or more than one pharmacies
Crystalline cellulose, hypromellose, polyethylene glycol, magnesium stearate, superfine silica gel powder, xylitol, lactitol, glucose, sweet ammonia
The various dosage forms that acid, mannitol, glycine etc. are mixed, for example, can be made into liquid drugs injection, tablet, sustained release tablets, dripping pill, particle
Agent, powder-injection, capsule, fine granule.Preferred dosage form is dripping pill, capsule.
The Chinese medicine composition of the present invention makes full use of bulk pharmaceutical chemicals to carry out scientific matching, generates coordinating effect, reduces fat, compared with
Traditional preparation has more preferable curative effect, and quality is more controllable, is suitble to industrialized production.
Test example
Below by clinical testing data, the advantageous effect that further illustrates the present invention：
1, data and method
1.1 research object：40 volunteers participate in, age 25-45 Sui, male 22, women 18.All objects are equal
Non-smoking history, no heart and lung diseases and skeletal muscle disease, and sings and symptoms of the exercise test without myocardial ischemia before experiment（Fortune
Aroused in interest electrograph shows ST sections and forces down within 1mm）.
1.2 experimental method：In the case of double blind, volunteer is randomized to either experimental group according to random table（n=20）
Or control group（n=20）.Research object is required to keep life style relatively constant during the test, including eating habit,
Exercise and other daily routines, and other Chinese herbal medicines and Western medicine are not taken.Experimental group takes the preparation of the embodiment of the present invention three
Capsule, 2 times a day, 3 tablets each time；Control group takes placebo, totally 8 weeks.Before and after experiment, the 0th week and the 8th week, weight is measured
And body fat percentage.
1.3 statistical procedures
Measurement data with mean ± standard deviation () indicate, it is examined using t；Enumeration data x2It examines, P ＜ 0.05 are
Difference is significant.
1.4 result
Specific data see the table below：
Table 1 tests front and back weight and body fat variation
# p ＜ 0.05
1.5 discussing：
After treatment in 8 weeks, the weight and body fat level of control group are without significant change；The weight and body fat of experimental group are horizontal apparent
It reduces, it is statistically significant.Show that the present composition has the function of fat reducing.
Specific implementation mode
Embodiment 1
（1）The preparation of cassia seed, rheum officinale and dried orange peel extracts
Depend on pine torch, rheum officinale and dried orange peel raw material, volume ratio 1 is added after being crushed:2 ethyl acetate and 70% ethyl alcohol, add
Circumfluence distillation 2 times, 1.5 hours for the first time, second 1 hour, filtrate merged to obtain extracting solution I, and the dregs of a decoction are added 70% ethyl alcohol, add
Circumfluence distillation 2 times, 1 hour for the first time, second 0.5 hour, filtrate merged to obtain extracting solution II；Merge extracting solution I and II, it is dense
It shortens medicinal extract into, dissolves medicinal extract with 50% methanol, detached using macroreticular resin AB-8, first with 65% ethanol elution, must be eluted
Liquid I；Again with 85% ethanol elution, eluent flow rate 2.5BV/h obtains eluent II, recycles, and is concentrated under reduced pressure, it is dry to get.
（2）The preparation of lotus leaf, rhizoma alismatis and Folum Ilicis extract
By raw material extracting in water 2 times, 6 times of amount water are added for the first time, 90 DEG C~100 DEG C of temperature is kept for 1.5 hours, filtering；
Second of addition, 4 times of amount water, 90 DEG C~100 DEG C of temperature are kept for 0.5 hour, filtering, merging filtrate；Macroporous absorption tree on filtrate
Then fat collects eluent with 60%~95% ethanol elution again first with 20% ethanol elution；Steam pressure 0.01Mpa, vacuum
Degree -0.03Mpa, temperature 60 C are concentrated into relative density 1.20g/cm3Medicinal extract；Vacuum degree -0.04Mpa, temperature 60 C are done
It is dry, crushed 60 mesh sieve to get.
Above-mentioned Lotus Leafextract 79g, Alisma extract 5g, Folum Ilicis extract 4g, cassia seed extract 2g, rheum officinale is taken to carry
Object 4g, dried orange peel extracts 6g are taken, auxiliary material is added, dripping pill 10000 is made.
Embodiment 2
（1）It is prepared by cassia seed, rheum officinale and dried orange peel extracts
Depend on pine torch, rheum officinale and dried orange peel raw material, volume ratio 1 is added after being crushed:2 ethyl acetate and 70% ethyl alcohol, add
Circumfluence distillation 2 times, 1.5 hours for the first time, second 1 hour, filtrate merged to obtain extracting solution I, and the dregs of a decoction are added 70% ethyl alcohol, add
Circumfluence distillation 2 times, 1 hour for the first time, second 0.5 hour, filtrate merged to obtain extracting solution II；Merge extracting solution I and II, it is dense
It shortens medicinal extract into, dissolves medicinal extract with 50% methanol, detached using macroreticular resin X-5, first with 70% ethanol elution, obtain eluent
I；Again with 90% ethanol elution, eluent flow rate 2BV/h obtains eluent II, recycles, and is concentrated under reduced pressure, it is dry to get.
（2）The preparation of lotus leaf, rhizoma alismatis and Folum Ilicis extract
By raw material extracting in water 2 times, 10 times of amount water are added for the first time, 90 DEG C~100 DEG C of temperature is kept for 3 hours, filtering；The
Secondary that 8 times of amount water are added, 90 DEG C~100 DEG C of temperature is kept for 1.5 hours, filtering, merging filtrate；Macroporous absorbent resin on filtrate,
First with 60% ethanol elution, then eluent is collected with 95% ethanol elution again；Steam pressure 0.09Mpa, vacuum degree-
0.08Mpa, 80 DEG C of temperature, is concentrated into relative density 1.25g/cm3Medicinal extract；Vacuum degree -0.09Mpa, 95 DEG C of temperature is dry,
Crushed 60 mesh sieve to get.
Above-mentioned Lotus Leafextract 3g, Alisma extract 5g, Folum Ilicis extract 4g, cassia seed extract 78g, rheum officinale is taken to carry
Object 4g, dried orange peel extracts 6g are taken, auxiliary material is added, capsule 1000 is made.
Embodiment 3
（1）It is prepared by cassia seed, rheum officinale and dried orange peel extracts
Depend on pine torch, rheum officinale and dried orange peel raw material, volume ratio 1 is added after being crushed:2 ethyl acetate and 70% ethyl alcohol, add
Circumfluence distillation 2 times, 2 hours for the first time, second 1 hour, filtrate merged to obtain extracting solution I, and 70% ethyl alcohol, heating is added in the dregs of a decoction
Refluxing extraction 2 times, 1 hour for the first time, second 0.5 hour, filtrate merged to obtain extracting solution II；Merge extracting solution I and II, concentration
At medicinal extract, medicinal extract is dissolved with 50% ethyl alcohol, is detached using macroreticular resin X-5, first with 65% ethanol elution, obtains eluent I；
Again with 90% ethanol elution, eluent flow rate 2BV/h obtains eluent II, recycles, and is concentrated under reduced pressure, it is dry to get.
（2）The preparation of lotus leaf, rhizoma alismatis and Folum Ilicis extract
By raw material extracting in water 2 times, 8 times of amount water are added for the first time, 90 DEG C~100 DEG C of temperature is kept for 2 hours, filtering；The
Secondary that 6 times of amount water are added, 90 DEG C~100 DEG C of temperature is kept for 1 hour, filtering, merging filtrate；Macroporous absorbent resin on filtrate, first
With 30% ethanol elution, then eluent is collected with 70% ethanol elution again；Steam pressure 0.04Mpa, vacuum degree -0.04Mpa,
65 DEG C of temperature, is concentrated into relative density 1.20g/cm3Medicinal extract；Vacuum degree -0.04Mpa, temperature 70 C dry, pulverize 60
Mesh sieve to get.
Above-mentioned Lotus Leafextract 25g, Alisma extract 13g, Folum Ilicis extract 15g, cassia seed extract 20g are taken, greatly
Yellow extract 12g, dried orange peel extracts 15g are added auxiliary material and capsule 1000 are made.
Embodiment 4
（1）It is prepared by cassia seed, rheum officinale and dried orange peel extracts
Depend on pine torch, rheum officinale and dried orange peel raw material, volume ratio 1 is added after being crushed:2 ethyl acetate and 70% ethyl alcohol, add
Circumfluence distillation 2 times, 1 hour for the first time, second 1 hour, filtrate merged to obtain extracting solution I, and 70% ethyl alcohol, heating is added in the dregs of a decoction
Refluxing extraction 2 times, 0.5 hour for the first time, second 0.5 hour, filtrate merged to obtain extracting solution II；Merge extracting solution I and II, it is dense
It shortens medicinal extract into, dissolves medicinal extract with 50% ethyl alcohol, detached using macroreticular resin AB-8, first with 65% ethanol elution, must be eluted
Liquid I；Again with 90% ethanol elution, eluent flow rate 1BV/h obtains eluent II, recycles, and is concentrated under reduced pressure, it is dry to get.
（2）The preparation of lotus leaf, rhizoma alismatis and Folum Ilicis extract
By raw material extracting in water 2 times, 8 times of amount water are added for the first time, 90 DEG C~100 DEG C of temperature is kept for 2 hours, filtering；The
Secondary that 6 times of amount water are added, 90 DEG C~100 DEG C of temperature is kept for 1 hour, filtering, merging filtrate；Macroporous absorbent resin on filtrate, first
With 55% ethanol elution, then eluent is collected with 90% ethanol elution again；Steam pressure 0.07Mpa, vacuum degree -0.06Mpa,
75 DEG C of temperature, is concentrated into relative density 1.25g/cm3Medicinal extract；Vacuum degree -0.08Mpa, 90 DEG C of temperature, dry, pulverize 60
Mesh sieve to get.
Above-mentioned Lotus Leafextract 10g, Alisma extract 18g, Folum Ilicis extract 40g, cassia seed extract 12g are taken, greatly
Yellow extract 10g, dried orange peel extracts 10g are added auxiliary material and capsule 1000 are made.
Embodiment 5
（1）It is prepared by cassia seed, rheum officinale and dried orange peel extracts
Depend on pine torch, rheum officinale and dried orange peel raw material, volume ratio 1 is added after being crushed:2 ethyl acetate and 70% ethyl alcohol, add
Circumfluence distillation 2 times, 3 hours for the first time, second 2 hours, filtrate merged to obtain extracting solution I, and 70% ethyl alcohol, heating is added in the dregs of a decoction
Refluxing extraction 2 times, 1.5 hours for the first time, second 1 hour, filtrate merged to obtain extracting solution II；Merge extracting solution I and II, concentration
At medicinal extract, medicinal extract is dissolved with 50% ethyl alcohol, is detached using macroreticular resin X-5, first with 70% ethanol elution, obtains eluent I；
Again with 88% ethanol elution, eluent flow rate 4BV/h obtains eluent II, recycles, and is concentrated under reduced pressure, it is dry to get.
（2）The preparation of lotus leaf, rhizoma alismatis and Folum Ilicis extract
By raw material extracting in water 2 times, 8 times of amount water are added for the first time, 90 DEG C~100 DEG C of temperature is kept for 2 hours, filtering；The
Secondary that 6 times of amount water are added, 90 DEG C~100 DEG C of temperature is kept for 1 hour, filtering, merging filtrate；Macroporous absorbent resin on filtrate, first
With 35% ethanol elution, then eluent is collected with 75% ethanol elution again；Steam pressure 0.05Mpa, vacuum degree -0.06Mpa,
Temperature 70 C is concentrated into relative density 1.23g/cm3Medicinal extract；Vacuum degree -0.06Mpa, 80 DEG C of temperature, dry, pulverize 60
Mesh sieve to get.
Take above-mentioned Lotus Leafextract 55g, Alisma extract 8g, Folum Ilicis extract 10g, cassia seed extract 5g, rheum officinale
Extract 10g, dried orange peel extracts 12g are added auxiliary material and capsule 1000 are made.
Embodiment 6
（1）It is prepared by cassia seed, rheum officinale and dried orange peel extracts
Depend on pine torch, rheum officinale and dried orange peel raw material, volume ratio 1 is added after being crushed:2 ethyl acetate and 70% ethyl alcohol, add
Circumfluence distillation 2 times, 1.5 hours for the first time, second 1 hour, filtrate merged to obtain extracting solution I, and the dregs of a decoction are added 70% ethyl alcohol, add
Circumfluence distillation 2 times, 1 hour for the first time, second 0.5 hour, filtrate merged to obtain extracting solution II；Merge extracting solution I and II, it is dense
It shortens medicinal extract into, dissolves medicinal extract with 50% ethyl alcohol, detached using macroreticular resin X-5, first with 65% ethanol elution, obtain eluent
I；Again with 86% ethanol elution, eluent flow rate 2BV/h obtains eluent II, recycles, and is concentrated under reduced pressure, it is dry to get.
（2）The preparation of lotus leaf, rhizoma alismatis and Folum Ilicis extract
By raw material extracting in water 2 times, 10 times of amount water are added for the first time, 90 DEG C~100 DEG C of temperature is kept for 3 hours, filtering；The
Secondary that 8 times of amount water are added, 90 DEG C~100 DEG C of temperature is kept for 1.5 hours, filtering, merging filtrate；Macroporous absorbent resin on filtrate,
First with 50% ethanol elution, then eluent is collected with 75% ethanol elution again；Steam pressure 0.07Mpa, vacuum degree-
0.06Mpa, 65 DEG C of temperature, is concentrated into relative density 1.21g/cm3Medicinal extract；Vacuum degree -0.05Mpa, 75 DEG C of temperature is dry,
Crushed 60 mesh sieve to get.
Above-mentioned Lotus Leafextract 30g, Alisma extract 15g, Folum Ilicis extract 15g, cassia seed extract 10g are taken, greatly
Yellow extract 10g, dried orange peel extracts 20g are added auxiliary material and 1000 bags of electuary are made.
Embodiment 7
（1）It is prepared by cassia seed, rheum officinale and dried orange peel extracts
Depend on pine torch, rheum officinale and dried orange peel raw material, volume ratio 1 is added after being crushed:2 ethyl acetate and 70% ethyl alcohol, add
Circumfluence distillation 2 times, 2 hours for the first time, second 1 hour, filtrate merged to obtain extracting solution I, and 70% ethyl alcohol, heating is added in the dregs of a decoction
Refluxing extraction 2 times, 1.5 hours for the first time, second 1 hour, filtrate merged to obtain extracting solution II；Merge extracting solution I and II, concentration
At medicinal extract, medicinal extract is dissolved with 50% ethyl alcohol, is detached using macroreticular resin X-5, first with 70% ethanol elution, obtains eluent I；
Again with 90% ethanol elution, eluent flow rate 3BV/h obtains eluent II, recycles, and is concentrated under reduced pressure, and drying is always yellow to get sea-buckthorn
Ketone extract.
（2）The preparation of lotus leaf, rhizoma alismatis and Folum Ilicis extract
By raw material extracting in water 2 times, 7 times of amount water are added for the first time, 90 DEG C~100 DEG C of temperature is kept for 2.5 hours, filtering；
Second of addition, 7 times of amount water, 90 DEG C~100 DEG C of temperature are kept for 1.5 hours, filtering, merging filtrate；Macroporous absorption tree on filtrate
Then fat collects eluent with 55% ethanol elution again first with 30% ethanol elution；Steam pressure 0.03Mpa, vacuum degree-
0.04Mpa, 75 DEG C of temperature, is concentrated into relative density 1.24g/cm3Medicinal extract；Vacuum degree -0.07Mpa, 65 DEG C of temperature is dry,
Crushed 60 mesh sieve to get.
Above-mentioned Lotus Leafextract 10g, Alisma extract 25g, Folum Ilicis extract 12g, cassia seed extract 16g are taken, greatly
Yellow extract 12g, dried orange peel extracts 25g are added auxiliary material and 1000 bags of electuary are made.
Embodiment 8
（1）It is prepared by cassia seed, rheum officinale and dried orange peel extracts
Depend on pine torch, rheum officinale and dried orange peel raw material, volume ratio 1 is added after being crushed:2 ethyl acetate and 70% ethyl alcohol, add
Circumfluence distillation 2 times, 2 hours for the first time, second 2 hours, filtrate merged to obtain extracting solution I, and 70% ethyl alcohol, heating is added in the dregs of a decoction
Refluxing extraction 2 times, 1.5 hours for the first time, second 1 hour, filtrate merged to obtain extracting solution II；Merge extracting solution I and II, concentration
At medicinal extract, medicinal extract is dissolved with 50% ethyl alcohol, is detached using macroreticular resin AB-8, first with 67% ethanol elution, obtains eluent
I；Again with 84% ethanol elution, eluent flow rate 2BV/h obtains eluent II, recycles, and is concentrated under reduced pressure, it is dry to get.
（2）The preparation of lotus leaf, rhizoma alismatis and Folum Ilicis extract
By raw material extracting in water 2 times, 9 times of amount water are added for the first time, 90 DEG C~100 DEG C of temperature is kept for 3 hours, filtering；The
Secondary that 8 times of amount water are added, 90 DEG C~100 DEG C of temperature is kept for 1.5 hours, filtering, merging filtrate；Macroporous absorbent resin on filtrate,
First with 59% ethanol elution, then eluent is collected with 85% ethanol elution again；Steam pressure 0.08Mpa, vacuum degree-
0.07Mpa, 78 DEG C of temperature, is concentrated into relative density 1.20g/cm3Medicinal extract；Vacuum degree -0.04Mpa, 90 DEG C of temperature is dry,
Crushed 60 mesh sieve to get.
Above-mentioned Lotus Leafextract 14g, Alisma extract 14g, Folum Ilicis extract 30g, cassia seed extract 16g are taken, greatly
Yellow extract 10g, dried orange peel extracts 16g are added auxiliary material and 1000 bags of electuary are made.
Embodiment 9
（1）It is prepared by cassia seed, rheum officinale and dried orange peel extracts
Depend on pine torch, rheum officinale and dried orange peel raw material, volume ratio 1 is added after being crushed:2 ethyl acetate and 70% ethyl alcohol, add
Circumfluence distillation 2 times, 1.5 hours for the first time, second 1.5 hours, filtrate merged to obtain extracting solution I, and 70% ethyl alcohol is added in the dregs of a decoction,
Heating and refluxing extraction 2 times, 1 hour for the first time, second 1 hour, filtrate merged to obtain extracting solution II；Merge extracting solution I and II, it is dense
It shortens medicinal extract into, dissolves medicinal extract with 50% ethyl alcohol, detached using macroreticular resin-X-5, first with 68% ethanol elution, must be eluted
Liquid I；Then with, then with 89% ethanol elution, eluent flow rate 2.5BV/h obtains eluent II, recycles, and is concentrated under reduced pressure, dry,
To obtain the final product.
（2）The preparation of lotus leaf, rhizoma alismatis and Folum Ilicis extract
By raw material extracting in water 2 times, 6 times of amount water are added for the first time, 90 DEG C~100 DEG C of temperature is kept for 1.5 hours, filtering；
Second of addition, 4 times of amount water, 90 DEG C~100 DEG C of temperature are kept for 1.5 hours, filtering, merging filtrate；Macroporous absorption tree on filtrate
Then fat collects eluent with 80% ethanol elution again first with 40% ethanol elution；Steam pressure 0.09Mpa, vacuum degree-
0.08Mpa, temperature 60 C are concentrated into relative density 1.25g/cm3Medicinal extract；Vacuum degree -0.04Mpa, 95 DEG C of temperature is dry,
Crushed 60 mesh sieve to get.
Above-mentioned Lotus Leafextract 17g, Alisma extract 20g, Folum Ilicis extract 13g, cassia seed extract 30g are taken, greatly
Yellow extract 10g, dried orange peel extracts 10g are added auxiliary material and 1000 bags of electuary are made.
Embodiment 10
（1）It is prepared by cassia seed, rheum officinale and dried orange peel extracts
Depend on pine torch, rheum officinale and dried orange peel raw material, volume ratio 1 is added after being crushed:2 ethyl acetate and 70% ethyl alcohol, add
Circumfluence distillation 2 times, 3 hours for the first time, second 2 hours, filtrate merged to obtain extracting solution I, and 70% ethyl alcohol, heating is added in the dregs of a decoction
Refluxing extraction 2 times, 1.5 hours for the first time, second 1 hour, filtrate merged to obtain extracting solution II；Merge extracting solution I and II, concentration
At medicinal extract, medicinal extract is dissolved with 50% ethyl alcohol, is detached using macroreticular resin X-5, first with 65% ethanol elution, obtains eluent I；
Again with 90% ethanol elution, eluent flow rate 2BV/h obtains eluent II, recycles, and is concentrated under reduced pressure, it is dry to get.
（2）The preparation of lotus leaf, rhizoma alismatis and Folum Ilicis extract
By raw material extracting in water 2 times, 9 times of amount water are added for the first time, 90 DEG C~100 DEG C of temperature is kept for 3 hours, filtering；The
Secondary that 7 times of amount water are added, 90 DEG C~100 DEG C of temperature is kept for 0.5 hour, filtering, merging filtrate；Macroporous absorbent resin on filtrate,
First with 45% ethanol elution, then eluent is collected with 75% ethanol elution again；Steam pressure 0.04Mpa, vacuum degree-
0.05Mpa, temperature 70 C are concentrated into relative density 1.20g/cm3Medicinal extract；Vacuum degree -0.04Mpa, temperature 60 C is dry,
Crushed 60 mesh sieve to get.
Above-mentioned Lotus Leafextract 10g, Alisma extract 19g, Folum Ilicis extract 11g, cassia seed extract 20g are taken, greatly
Yellow extract 15g, dried orange peel extracts 25g are added auxiliary material and 1000, tablet are made.
Embodiment 11
（1）It is prepared by cassia seed, rheum officinale and dried orange peel extracts
Depend on pine torch, rheum officinale and dried orange peel raw material, volume ratio 1 is added after being crushed:2 ethyl acetate and 70% ethyl alcohol, add
Circumfluence distillation 2 times, 2.5 hours for the first time, second 1.5 hours, filtrate merged to obtain extracting solution I, and 70% ethyl alcohol is added in the dregs of a decoction,
Heating and refluxing extraction 2 times, 1 hour for the first time, second 0.5 hour, filtrate merged to obtain extracting solution II；Merge extracting solution I and II,
It is condensed into medicinal extract, medicinal extract is dissolved with 50% ethyl alcohol, is detached using macroreticular resin AB-8, first with 65% ethanol elution, must be washed
De- liquid I；Again with 89% ethanol elution, eluent flow rate 3.5BV/h obtains eluent II, recycles, and is concentrated under reduced pressure, it is dry to get.
（2）The preparation of lotus leaf, rhizoma alismatis and Folum Ilicis extract
By raw material extracting in water 2 times, 6 times of amount water are added for the first time, 90 DEG C~100 DEG C of temperature is kept for 1.5 hours, filtering；
Second of addition, 8 times of amount water, 90 DEG C~100 DEG C of temperature are kept for 1 hour, filtering, merging filtrate；Macroporous absorbent resin on filtrate,
First with 25% ethanol elution, then eluent is collected with 85% ethanol elution again；Steam pressure 0.01Mpa, vacuum degree-
0.03Mpa, temperature 70 C are concentrated into relative density 1.25g/cm3Medicinal extract；Vacuum degree -0.09Mpa, 95 DEG C of temperature is dry,
Crushed 60 mesh sieve to get.
Take above-mentioned Lotus Leafextract 9g, Alisma extract 25g, Folum Ilicis extract 21g, cassia seed extract 8g, rheum officinale
Extract 6g, dried orange peel extracts 31g are added auxiliary material and 1000 bags of electuary are made.
Embodiment 12
（1）It is prepared by cassia seed, rheum officinale and dried orange peel extracts
Depend on pine torch, rheum officinale and dried orange peel raw material, volume ratio 1 is added after being crushed:2 ethyl acetate and 70% ethyl alcohol, add
Circumfluence distillation 2 times, 2.5 hours for the first time, second 1.5 hours, filtrate merged to obtain extracting solution I, and 70% ethyl alcohol is added in the dregs of a decoction,
Heating and refluxing extraction 2 times, 1.5 hours for the first time, second 0.5 hour, filtrate merged to obtain extracting solution II；Merge extracting solution I and
II is condensed into medicinal extract, dissolves medicinal extract with 50% ethyl alcohol, is detached using macroreticular resin X-5, first with 66% ethanol elution, obtained
Eluent I；Again with 87% ethanol elution, eluent flow rate 4BV/h obtains eluent II, recycles, and is concentrated under reduced pressure, it is dry to get.
（2）The preparation of lotus leaf, rhizoma alismatis and Folum Ilicis extract
By raw material extracting in water 2 times, 8 times of amount water are added for the first time, 90 DEG C~100 DEG C of temperature is kept for 2 hours, filtering；The
Secondary that 8 times of amount water are added, 90 DEG C~100 DEG C of temperature is kept for 1 hour, filtering, merging filtrate；Macroporous absorbent resin on filtrate, first
With 55% ethanol elution, then eluent is collected with 80% ethanol elution again；Steam pressure 0.09Mpa, vacuum degree -0.08Mpa,
63 DEG C of temperature, is concentrated into relative density 1.21g/cm3Medicinal extract；Vacuum degree -0.06Mpa, 85 DEG C of temperature, dry, pulverize 60
Mesh sieve to get.
Take above-mentioned Lotus Leafextract 25g, Alisma extract 15g, Folum Ilicis extract 8g, cassia seed extract 22g, rheum officinale
Extract 15g, dried orange peel extracts 15g are added auxiliary material and capsule 1000 are made.
Embodiment 13
（1）It is prepared by cassia seed, rheum officinale and dried orange peel extracts
Depend on pine torch, rheum officinale and dried orange peel raw material, volume ratio 1 is added after being crushed:2 ethyl acetate and 70% ethyl alcohol, add
Circumfluence distillation 2 times, 3 hours for the first time, second 1 hour, filtrate merged to obtain extracting solution I, and 70% ethyl alcohol, heating is added in the dregs of a decoction
Refluxing extraction 2 times, 0.5 hour for the first time, second 0.5 hour, filtrate merged to obtain extracting solution II；Merge extracting solution I and II, it is dense
It shortens medicinal extract into, dissolves medicinal extract with 50% ethyl alcohol, detached using macroreticular resin X-5, first with 66% ethanol elution, obtain eluent
I；Again with 87% ethanol elution, eluent flow rate 3.5BV/h obtains eluent II, recycles, and is concentrated under reduced pressure, it is dry to get.
（2）The preparation of lotus leaf, rhizoma alismatis and Folum Ilicis extract
By raw material extracting in water 2 times, 7 times of amount water are added for the first time, 90 DEG C~100 DEG C of temperature is kept for 1.5 hours, filtering；
Second of addition, 5 times of amount water, 90 DEG C~100 DEG C of temperature are kept for 0.8 hour, filtering, merging filtrate；Macroporous absorption tree on filtrate
Then fat collects eluent with 65% ethanol elution again first with 45% ethanol elution；Steam pressure 0.07Mpa, vacuum degree-
0.05Mpa, 78 DEG C of temperature, is concentrated into relative density 1.20g/cm3Medicinal extract；Vacuum degree -0.06Mpa, 65 DEG C of temperature is dry,
Crushed 60 mesh sieve to get.
Above-mentioned Lotus Leafextract 28g, Alisma extract 14g, Folum Ilicis extract 30g, cassia seed extract 15g are taken, greatly
Yellow extract 6g, dried orange peel extracts 7g are added auxiliary material and capsule 1000 are made.
Embodiment 14
Lotus leaf, rhizoma alismatis, Ilex Latifolia Thunb, cassia seed, rheum officinale and dried orange peel raw material are taken, extract is prepared respectively using following methods：
Volume ratio 1 is added after raw material is crushed:2 ethyl acetate and 70% ethyl alcohol, heating and refluxing extraction 2 times, 1 hour for the first time, second
Secondary 1 hour, filtrate merged to obtain extracting solution I, and the dregs of a decoction are added 70% ethyl alcohol, heating and refluxing extraction 2 times, 0.5 hour for the first time, and second
Secondary 0.5 hour, filtrate merged to obtain extracting solution II；Merge extracting solution I and II, be condensed into medicinal extract, dissolves medicinal extract with 50% ethyl alcohol, adopt
It is detached with macroreticular resin AB-8, first with 68% ethanol elution, obtains eluent I；Again with 85% ethanol elution, eluent flow rate
For 1.5BV/h, obtain eluent II, recycle, be concentrated under reduced pressure, it is dry to get.
Above-mentioned Lotus Leafextract 28g, Alisma extract 14g, Folum Ilicis extract 30g, cassia seed extract 15g are taken, greatly
Yellow extract 6g, dried orange peel extracts 7g are added auxiliary material and 1000, tablet are made.
Embodiment 15
Lotus leaf, rhizoma alismatis, Ilex Latifolia Thunb, cassia seed, rheum officinale and dried orange peel raw material are taken, extract is prepared respectively using following methods：
Volume ratio 1 is added after raw material is crushed:2 ethyl acetate and 70% ethyl alcohol, heating and refluxing extraction 2 times, 1.5 hours for the first time, the
Secondary 1 hour, filtrate merged to obtain extracting solution I, and the dregs of a decoction are added 70% ethyl alcohol, heating and refluxing extraction 2 times, 1.5 hours for the first time, the
Secondary 0.5 hour, filtrate merged to obtain extracting solution II；Merge extracting solution I and II, be condensed into medicinal extract, dissolves medicinal extract with 50% ethyl alcohol,
It is detached using macroreticular resin X~5, first with 65% ethanol elution, obtains eluent I；Again with 95% ethanol elution, liquid stream is eluted
Speed is 2.5BV/h, obtains eluent II, is recycled, and is concentrated under reduced pressure, it is dry to get.
Above-mentioned Lotus Leafextract 25g, Alisma extract 13g, Folum Ilicis extract 15g, cassia seed extract 20g are taken, greatly
Yellow extract 12g, dried orange peel extracts 15g are added auxiliary material and 1000, tablet are made.
Embodiment 16
Lotus leaf, rhizoma alismatis, Ilex Latifolia Thunb, cassia seed, rheum officinale and dried orange peel raw material are taken, extract is prepared respectively using following methods：
Volume ratio 1 is added after raw material is crushed:2 ethyl acetate and 70% ethyl alcohol, heating and refluxing extraction 2 times, 3 hours for the first time, second
Secondary 2 hours, filtrate merged to obtain extracting solution I, and the dregs of a decoction are added 70% ethyl alcohol, heating and refluxing extraction 2 times, 1 hour for the first time, second 1
Hour, filtrate merges to obtain extracting solution II；Merge extracting solution I and II, be condensed into medicinal extract, medicinal extract is dissolved with 50% ethyl alcohol, using macropore
Resin A B-8 is detached, and first with 70% ethanol elution, obtains eluent I；Again with 95% ethanol elution, eluent flow rate 3BV/
H obtains eluent II, recycles, and is concentrated under reduced pressure, it is dry to get.
Take above-mentioned Lotus Leafextract 55g, Alisma extract 8g, Folum Ilicis extract 10g, cassia seed extract 5g, rheum officinale
Extract 10g, dried orange peel extracts 12g are added auxiliary material and 1000, tablet are made.
Embodiment 17
Lotus leaf, rhizoma alismatis, Ilex Latifolia Thunb, cassia seed, rheum officinale and dried orange peel raw material are taken, extract is prepared respectively using following methods：
Volume ratio 1 is added after raw material is crushed:2 ethyl acetate and 70% ethyl alcohol, heating and refluxing extraction 2 times, 2.5 hours for the first time, the
Secondary 1 hour, filtrate merged to obtain extracting solution I, and the dregs of a decoction are added 70% ethyl alcohol, heating and refluxing extraction 2 times, 1 hour for the first time, and second
Secondary 0.5 hour, filtrate merged to obtain extracting solution II；Merge extracting solution I and II, be condensed into medicinal extract, dissolves medicinal extract with 50% ethyl alcohol, adopt
It is detached with macroreticular resin X-5, first with 68% ethanol elution, obtains eluent I；Again with 90% ethanol elution, eluent flow rate
For 1BV/h, obtain eluent II, recycle, be concentrated under reduced pressure, it is dry to get.
Above-mentioned Lotus Leafextract 10g, Alisma extract 19g, Folum Ilicis extract 11g, cassia seed extract 20g are taken, greatly
Yellow extract 15g, dried orange peel extracts 25g are added auxiliary material and 1000, tablet are made.
Embodiment 18
Lotus leaf, rhizoma alismatis, Ilex Latifolia Thunb, cassia seed, rheum officinale and dried orange peel raw material are taken, extract is prepared respectively using following methods：
Volume ratio 1 is added after raw material is crushed:2 ethyl acetate and 70% ethyl alcohol, heating and refluxing extraction 2 times, 3 hours for the first time, second
Secondary 2 hours, filtrate merged to obtain extracting solution I, and the dregs of a decoction are added 70% ethyl alcohol, heating and refluxing extraction 2 times, 1.5 hours for the first time, and second
Secondary 0.5 hour, filtrate merged to obtain extracting solution II；Merge extracting solution I and II, be condensed into medicinal extract, dissolves medicinal extract with 50% ethyl alcohol, adopt
It is detached with macroreticular resin AB-8, first with 69% ethanol elution, obtains eluent I；Again with 85% ethanol elution, eluent flow rate
For 1BV/h, obtain eluent II, recycle, be concentrated under reduced pressure, it is dry to get.
Above-mentioned Lotus Leafextract 3g, Alisma extract 5g, Folum Ilicis extract 4g, cassia seed extract 78g, rheum officinale is taken to carry
Object 4g, dried orange peel extracts 6g are taken, auxiliary material is added, capsule 1000 is made.
Chinese medicine composition disclosed by the invention, those skilled in the art can extract link by change and realize.The present invention
Embodiment be only specific descriptions to technical solution, be not the limitation to technical solution, those skilled in the art are not changing
Become the replacement done under conditions of the substantive content of the present invention or change each falls within protection scope of the present invention.
Claims (11)
1. a kind of fat reducing Chinese medicine composition, is made of following weight percents component：Lotus leaf 3%~79%, rhizoma alismatis 5%~
75%, Ilex Latifolia Thunb 4%~70%, cassia seed 2%~78%, rheum officinale 4%~45%, dried orange peel 6%~60%；Preparation method packet
Include following steps：
The preparation method of cassia seed, rheum officinale and dried orange peel extracts includes：Raw material is taken, ethyl acetate and second are added after being crushed
Alcohol, heating and refluxing extraction obtain extracting solution I, and ethyl alcohol is added in the dregs of a decoction, and heating and refluxing extraction obtains extracting solution II, merge extracting solution I and
II is condensed into medicinal extract, with ethyl alcohol dissolve medicinal extract, using nonpolarity or low pole macroreticular resin it is detached, first with
65%~70% ethanol elution obtains eluent I；Then with 85%~90% ethanol elution, eluent II is obtained, is recycled, decompression is dense
Contracting, it is dry to get；
Lotus leaf, rhizoma alismatis and Folum Ilicis extract preparation method include：
(1) by raw material extracting in water 2 times, 6~10 times of amount water are added for the first time, 90 DEG C~100 DEG C of temperature is kept for 1.5-3 hours,
Filtering；Second of addition, 4~8 times of amount water, 90 DEG C~100 DEG C of temperature are kept for 0.5~1.5 hour, filtering, merging filtrate；
(2) macroporous absorbent resin on filtrate, respectively for the second time with the elution for the first time of 20%~60% ethyl alcohol, 60%~95% ethyl alcohol
Eluent is collected in elution；
(3) 0.01~0.09Mpa of steam pressure, vacuum degree -0.03~-0.08Mpa, 50~85 DEG C of temperature are concentrated into relatively close
Spend 1.20~1.25g/cm3Medicinal extract；
(4) vacuum degree -0.04~-0.09Mpa, 60~95 DEG C of temperature, dry, pulverize 60 mesh sieve to get.
2. Chinese medicine composition according to claim 1, which is characterized in that be made of following weight percents component：Lotus leaf
10%~55%, rhizoma alismatis 8%~50%, Ilex Latifolia Thunb 10%~40%, cassia seed 5%~50%, rheum officinale 10%~35%, dried orange peel
10%~50%.
3. Chinese medicine composition according to claim 1, which is characterized in that be made of following weight percents component：Lotus leaf
10%~40%, rhizoma alismatis 10%~25%, Ilex Latifolia Thunb 10%~30%, cassia seed 10%~30%, rheum officinale 10%~25% is old
Skin 10%~35%.
4. Chinese medicine composition according to claim 1, which is characterized in that be made of following weight percents component：Lotus leaf
25%, rhizoma alismatis 13%, Ilex Latifolia Thunb 15%, cassia seed 20%, rheum officinale 12%, dried orange peel 15%.
5. Chinese medicine composition according to claim 1, which is characterized in that cassia seed, rheum officinale and the dried orange peel extracts
Preparation method in, the volume ratio of ethyl acetate and ethyl alcohol is 1:2；The volumetric concentration of elution ethyl alcohol is 65% for the first time；Second
The volumetric concentration of secondary elution ethyl alcohol is 90%.
6. Chinese medicine composition according to claim 1, which is characterized in that cassia seed, rheum officinale and the dried orange peel extracts
Preparation method include the following steps：
Raw material is taken, volume ratio 1 is added after being crushed:2 ethyl acetate and 70% ethyl alcohol, heating and refluxing extraction 2 times, for the first time
1~3 hour, second 1~2 hour, filtrate merged to obtain extracting solution I, and the dregs of a decoction are added 70% ethyl alcohol, heating and refluxing extraction 2 times, the
One time 0.5~1.5 hour, second 0.5~1 hour, filtrate merged to obtain extracting solution II, merges extracting solution I and II, is condensed into leaching
Cream is dissolved medicinal extract with 50% ethyl alcohol, is detached to it using nonpolarity or low pole macroreticular resin, 65%~70% second first
Alcohol elutes, and obtains eluent I；Again with 85%~90% ethanol elution, obtain eluent II, recycle, be concentrated under reduced pressure, it is dry to get.
7. Chinese medicine composition according to claim 6, which is characterized in that cassia seed, rheum officinale and the dried orange peel extracts
Preparation method in, macroreticular resin be AB-8 or X-5, elution flow rate be 1~4BV/h.
8. Chinese medicine composition according to claim 6, which is characterized in that cassia seed, rheum officinale and the dried orange peel extracts
Preparation method in, macroreticular resin X-5, elution flow rate be 1~2BV/h.
9. Chinese medicine composition according to claim 6, which is characterized in that cassia seed, rheum officinale and the dried orange peel extracts
Preparation method in, elution flow rate 2BV/h.
10. Chinese medicine composition according to claim 1, which is characterized in that lotus leaf, rhizoma alismatis and the Folum Ilicis extract
In preparation method, ethanol eluate volumetric concentration is respectively in step (2)：For the first time 30%~55%, second 70%~
80%；0.04~0.07Mpa of steam pressure in step (3), vacuum degree -0.04~-0.06Mpa, 65~75 DEG C of temperature are concentrated into
1.20~1.25g/cm of relative density3Medicinal extract.
11. preparation method according to claim 1, which is characterized in that ethanol eluate volumetric concentration is distinguished in step (2)
For：For the first time 35%, second 75%；Steam pressure 0.05Mpa in step (3), vacuum degree -0.06Mpa, temperature 70 C are dense
It is reduced to relative density 1.23g/cm3Medicinal extract.
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