CN102145017B - Method for improving hot-melt wall sticking in spray drying process of traditional Chinese medicinal extracting solution - Google Patents
Method for improving hot-melt wall sticking in spray drying process of traditional Chinese medicinal extracting solution Download PDFInfo
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- CN102145017B CN102145017B CN2010101080217A CN201010108021A CN102145017B CN 102145017 B CN102145017 B CN 102145017B CN 2010101080217 A CN2010101080217 A CN 2010101080217A CN 201010108021 A CN201010108021 A CN 201010108021A CN 102145017 B CN102145017 B CN 102145017B
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Abstract
The invention discloses a method for improving hot-melt wall sticking in the spray drying process of traditional Chinese medicinal extracting solution, which comprises the following steps of: adding light-weight magnesium oxide serving as an antisticking agent into traditional Chinese medicinal extracting solution to be processed, stirring and dispersing uniformly, and performing spray drying with stirring, wherein the solid content of the traditional Chinese medicinal extracting solution to be processed is between 0 and 50 percent, and the using amount of the light-weight magnesium oxide is 0.1 to 15 percent of the solid content of the traditional Chinese medicinal extracting solution to be processed. By the method, the hot-melt wall sticking in the spray drying process of the traditional Chinese medicinal extracting solution is improved effectively.
Description
Technical field
The invention belongs to the drying technique category, be specifically related to the method for a kind of wall sticking phenomenon that utilizes pharmaceutic adjuvant to improve to occur in the Chinese medicine extract spray-drying process (particularly through technological parameter adjustment can't the sticking wall of improved heat molten type).
Background technology
Spray-drying has advantages such as " instantaneous drying ", " the dry products quality is good ", " dry run is simple " as a kind of novel drying process, has been widely used in the dry run of traditional Chinese medicine extraction concentrate at present.But, the phenomenon that powder glues wall appears in the spray-drying process of Chinese medicine extract easily.
The sticking wall of powder is unusual stubborn problem in the Chinese medical extract spray-drying process, not only causes the serious waste of product, reduces economic efficacy, and also possibly cause the interruption of dry run when serious when gluing wall, makes production to proceed.According to the reason and the performance that produce; Roughly can be divided into 3 types of (Zhou Xueyong with gluing wall; High health care. the reason and the solution route (J) of the sticking wall of spray-drying. use chemical industry, 2007,36 (6): 599-602.): half wet stock glues the sticking wall of heat molten type and the dry powder surface attachment of wall, low-melting-point material.The Chinese medical extract particularly sticking wall of Chinese medicine alcohol extracting extract spray-drying is the most common, also the most hard to manage with the sticking wall of heat molten type.
At present, the method for improving the sticking wall of powder in the Chinese medicine extract spray-drying process in the production mainly contains: spray drying device is transformed, increased attachment device, as adopting chuck cooling tower wall, low temperature spray drying method etc.; And in extract, add auxiliary material.With respect to chuck cooling method and low temperature spray drying method, add the auxiliary material method and have advantage aspect operability and the performance driving economy, therefore be to improve the sticking wall of powder in the production at present to use the widest method.Add in the auxiliary material method; The kind of auxiliary material is comparatively commonly used with soluble starch, maltodextrin, but when being used to improve the sticking wall of heat molten type, consumption is generally bigger; Generally can reach (the Xiao Dan more than 50% of dried cream amount in the extract; Bian Hongyan. drying process with atomizing research (J) Chinese herbal medicine of root of Dahurain angelica granule, 2006,37 (6): 874-876.).Supplementary product consumption is big, will certainly reduce the medicine carrying amount of prescription, thereby causes the dose behind the preparations shaping excessive.Therefore, how to overcome the sticking wall of heat molten type in the Chinese medicine extract spray-drying process, the consumption that reduces auxiliary material simultaneously will seem most important.
Summary of the invention
Technical problem to be solved by this invention provides a kind of through selecting suitable pharmaceutic adjuvant to improve the method for the sticking wall of heat molten type of Chinese medicine extract spray-drying process.Supplementary product consumption of the present invention is few, and is noiseless to the release of drug main composition, and favorable reproducibility.
In order to solve the problems of the technologies described above; Technical scheme provided by the invention is following: a kind of method of improving the sticking wall of heat molten type in the Chinese medicine extract spray-drying process; Its innovative point is: at solid content is to add light magnesium oxide in the pending Chinese medicine extract of 0%-50% as antiplastering aid; The consumption of light magnesium oxide is the 0.1%-15% of pending traditional Chinese medicine extraction fluid solid content, and dispersed with stirring is even, and under stirring condition spray-drying.
Preferably; The present invention is above-mentioned to be improved in the method for the sticking wall of heat molten type in the Chinese medicine extract spray-drying process; When adding light magnesium oxide; In pending Chinese medicine extract, add microcrystalline cellulose (MCC) as anti-caking agent, the consumption of microcrystalline cellulose (MCC) is the 0%-5% of pending traditional Chinese medicine extraction fluid solid content.
Preferably, the present invention is above-mentioned to be improved in the method for the sticking wall of heat molten type in the Chinese medicine extract spray-drying process, and pending Chinese medicine extract is that Chinese medicine simple or compound serve as to extract solvent with water or different concentration ethanol, through suitably extracting and concentrate the concentrate that obtains; Or Chinese medicine simple or compound water extract after variable concentrations alcohol precipitation, filtration and concentrate the concentrate that obtains.
Embodiment subsequently will prove; The inventive method method can not only significantly be improved the sticking wall of heat molten type in the Chinese medicine extract spray-drying process, and has reduced supplementary product consumption significantly, and antiplastering aid is by original 50%-60%; Be reduced to 0.1%-15%, also improved the proterties of powder simultaneously.
The specific embodiment
Below in conjunction with specific embodiment, further set forth the present invention.These embodiment are interpreted as only being used to the present invention is described and are not used in restriction protection scope of the present invention.After the content of having read the present invention's record, those skilled in the art can do various changes or modification to the present invention, and these equivalences change and modify and fall into claim of the present invention institute restricted portion equally.
Embodiment 1: potenlin side's extract spray-drying
The potenlin sheet records kind for " the Sanitation Ministry medicine standard Chinese traditional patent formulation preparation " the 10th, is formed through extracting to make with extra care by wilsonii and the fruit of Chinese wolfberry 2 flavor Chinese medicines.Find that in experiment the sticking wall of heat molten type takes place when spray-drying potenlin side's extract easily, the powder yield is almost nil.
Improved spray drying process is: potenlin extracts through suitably concentrating, and obtains extracting concentrate (solid content: 10.7%); The MCC that makes antiplastering aid and account for dried cream amount 3% in the concentrate to the light magnesium oxide that wherein adds 10% makes anti-caking agent; Stirring makes and is uniformly dispersed, and under stirring condition, carry out spray-drying (BUCHI-B290 spray-drying appearance, technological parameter is set to: 120 ℃ of EATs; Atomizing pressure 55mm; Feed liquor speed 15%, air intake air quantity 90%), the average yield of three batch of powder is 90.69%.
Adopt the little agar diffusion method of version Chinese Pharmacopoeia two appendix XC three therapeutic methods of traditional Chinese medicine in 2005 that the release degree of principal component Syringin in the potenlin extract spray-dried powders is investigated, the cumulative release rate of Syringin behind 15min surpasses 75%, meets the requirement of release degree.
Embodiment 2: blue a kind of reed mentioned in ancient books side extract spray-drying
Blue a kind of reed mentioned in ancient books side is that national ministry standard is included (WS-214 (Z-033)-96), and extract obtains extracting concentrate (solid content: 11.7%) through suitably concentrating; The MCC that makes antiplastering aid and account for dried cream amount 5% in the concentrate to the light magnesium oxide that wherein adds the dried cream amount 9% in the concentrate that accounts for makes anti-caking agent; Stirring makes and is uniformly dispersed, and under stirring condition, carry out spray-drying (BUCHI-B290 spray-drying appearance, technological parameter is set to: 130 ℃ of EATs; Atomizing pressure mm; Feed liquor speed 15%, air intake air quantity 80%), the average yield of three batch of powder is 95.26%.
Adopt the little agar diffusion method of version Chinese Pharmacopoeia two appendix XC three therapeutic methods of traditional Chinese medicine in 2005 that the release degree of principal component Gardenoside in blue a kind of reed mentioned in ancient books extract spray-dried powders is investigated, the cumulative release rate of Gardenoside behind 15min surpasses 75%, meets the requirement of release degree.
Embodiment 3: clear (particle) the square extract spray-drying of drenching
Clear (particle) side of drenching includes (WS3-B-1237-92) for national ministry standard, and extract is concentrated through suitably, obtains relative density and be 1.05 concentrate; Light magnesium oxide to wherein adding the dried cream amount 5% in the concentrate that accounts for is made antiplastering aid; Stirring makes and is uniformly dispersed, and under stirring condition, carry out spray-drying (BUCHI-B290 spray-drying appearance, technological parameter is set to: 130 ℃ of EATs; Atomizing pressure mm; Feed liquor speed 15%, air intake air quantity 80%), the yield of powder brings up to 84.13% by 34.50%.
Adopt the little agar diffusion method of version Chinese Pharmacopoeia two appendix XC three therapeutic methods of traditional Chinese medicine in 2005 that the release degree of principal component Gardenoside in the square extract spray-dried powders of clear pouring (particle) is investigated, the cumulative release rate of Gardenoside behind 15min surpasses 75%, meets the requirement of release degree.
Embodiment 4: Fructus Corni extract spray-drying
Fructus Corni is tcm clinical practice medication commonly used, and its aqueous extract is 1.10 concentrate through suitably concentrating, obtaining relative density; Light magnesium oxide to wherein adding the dried cream amount 1% in the concentrate that accounts for is done antiplastering aid, is uniformly dispersed during stirring, and (the BUCHI-B290 spray-drying appearance that under stirring condition, carries out spray-drying; Technological parameter is set to: 130 ℃ of EATs, atomizing pressure mm, feed liquor speed 15%; Air intake air quantity 80%), yield brings up to 87.5% by 34.1%.
Embodiment 5: DANNING PIAN (side) extract spray-drying
DANNING PIAN is herbal species of including of 2005 editions Chinese Pharmacopoeias, and the extract that obtains by its method for making is 1.12 concentrate through suitably concentrating, obtaining relative density; Do antiplastering aid to wherein adding the light magnesium oxide that accounts for dry measure 15% in the concentrate; Be uniformly dispersed during stirring, and under stirring condition, carry out spray-drying (BUCHI-B290 spray-drying appearance, technological parameter is set to: 130 ℃ of EATs; Atomizing pressure mm; Feed liquor speed 15%, air intake air quantity 80%), yield brings up to 87.5% by 38.5%.
Claims (3)
1. one kind is improved the method that heat molten type glues wall in the Chinese medicine extract spray-drying process; It is characterized in that; At solid content is to add light magnesium oxide in the pending Chinese medicine extract of 0%-50% as antiplastering aid; The consumption of light magnesium oxide is the 0.1%-15% of pending traditional Chinese medicine extraction fluid solid content, and dispersed with stirring is even, and under stirring condition spray-drying.
2. the method for improving the sticking wall of heat molten type in the Chinese medicine extract spray-drying process according to claim 1; It is characterized in that; When adding light magnesium oxide; In pending Chinese medicine extract, add microcrystalline cellulose as anti-caking agent, the consumption of microcrystalline cellulose is the 0%-5% of pending traditional Chinese medicine extraction fluid solid content.
3. the method for improving the sticking wall of heat molten type in the Chinese medicine extract spray-drying process according to claim 1 and 2; It is characterized in that; Pending Chinese medicine extract is that Chinese medicine simple or compound serve as to extract solvent with water or different concentration ethanol, through suitably extracting and concentrate the concentrate that obtains; Or Chinese medicine simple or compound water extract after variable concentrations alcohol precipitation, filtration and concentrate the concentrate that obtains.
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| CN103623411B (en) * | 2013-12-11 | 2015-06-17 | 河北省农林科学院经济作物研究所 | Method for reducing use amount of auxiliary materials for spray drying of traditional Chinese medicine extract |
| CN109770221A (en) * | 2019-03-08 | 2019-05-21 | 滨州中裕食品有限公司 | A kind of preparation method of the full powder of natural tomato and its application in noodles |
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Non-Patent Citations (3)
| Title |
|---|
| 周学永等.喷雾干燥粘壁的原因与解决途径.《应用化工》.2007,第36卷(第06期),599-602. * |
| 曾亚森等.中药喷雾干燥防止粘壁技术的研究.《医药工程设计》.2006,第27卷(第03期),10-13. * |
| 杜松等.中药提取物吸湿、结块和发黏现象的机制分析.《中草药》.2008,第39卷(第06期),932-934. * |
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