CN104258108B - A kind of preparation method of compound tall gastrodia tuber preparation and the compound tall gastrodia tuber preparation of acquisition - Google Patents
A kind of preparation method of compound tall gastrodia tuber preparation and the compound tall gastrodia tuber preparation of acquisition Download PDFInfo
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- 238000002360 preparation method Methods 0.000 title claims abstract description 66
- 150000001875 compounds Chemical class 0.000 title claims abstract description 40
- 241000305492 Gastrodia Species 0.000 title claims abstract description 37
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 125
- 239000006071 cream Substances 0.000 claims abstract description 64
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 36
- 238000005325 percolation Methods 0.000 claims abstract description 21
- 238000001035 drying Methods 0.000 claims abstract description 19
- 239000002775 capsule Substances 0.000 claims abstract description 11
- 239000007902 hard capsule Substances 0.000 claims abstract description 11
- 239000000203 mixture Substances 0.000 claims abstract description 11
- 238000010992 reflux Methods 0.000 claims abstract description 9
- 239000000843 powder Substances 0.000 claims description 41
- 230000006837 decompression Effects 0.000 claims description 31
- 239000000284 extract Substances 0.000 claims description 28
- 238000002156 mixing Methods 0.000 claims description 19
- 239000000469 ethanolic extract Substances 0.000 claims description 15
- 238000004064 recycling Methods 0.000 claims description 12
- 238000005507 spraying Methods 0.000 claims description 12
- 239000007788 liquid Substances 0.000 claims description 10
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 10
- 229960002901 sodium glycerophosphate Drugs 0.000 claims description 9
- REULQIKBNNDNDX-UHFFFAOYSA-M sodium;2,3-dihydroxypropyl hydrogen phosphate Chemical compound [Na+].OCC(O)COP(O)([O-])=O REULQIKBNNDNDX-UHFFFAOYSA-M 0.000 claims description 9
- 238000010438 heat treatment Methods 0.000 claims description 7
- 230000000740 bleeding effect Effects 0.000 claims description 6
- 238000007789 sealing Methods 0.000 claims description 6
- 235000019359 magnesium stearate Nutrition 0.000 claims description 5
- 239000003814 drug Substances 0.000 abstract description 22
- PUQSUZTXKPLAPR-UJPOAAIJSA-N Gastrodin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(CO)C=C1 PUQSUZTXKPLAPR-UJPOAAIJSA-N 0.000 abstract description 13
- 230000000694 effects Effects 0.000 abstract description 12
- 239000004615 ingredient Substances 0.000 abstract description 8
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 abstract description 6
- 229930006000 Sucrose Natural products 0.000 abstract description 6
- 239000002671 adjuvant Substances 0.000 abstract description 6
- 239000005720 sucrose Substances 0.000 abstract description 6
- 239000004375 Dextrin Substances 0.000 abstract description 5
- 229920001353 Dextrin Polymers 0.000 abstract description 5
- 235000019425 dextrin Nutrition 0.000 abstract description 5
- 239000008187 granular material Substances 0.000 abstract description 4
- 238000001914 filtration Methods 0.000 abstract description 3
- 239000000463 material Substances 0.000 abstract description 3
- 229940126678 chinese medicines Drugs 0.000 abstract description 2
- 239000002552 dosage form Substances 0.000 abstract 1
- 239000000706 filtrate Substances 0.000 abstract 1
- 239000000047 product Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 description 19
- 230000000052 comparative effect Effects 0.000 description 8
- 239000012153 distilled water Substances 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 6
- 239000002994 raw material Substances 0.000 description 6
- 241000305491 Gastrodia elata Species 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 230000003345 hyperglycaemic effect Effects 0.000 description 4
- 230000002421 anti-septic effect Effects 0.000 description 3
- 238000003556 assay Methods 0.000 description 3
- JEJFTTRHGBKKEI-OKILXGFUSA-N deoxyschizandrin Chemical compound C1[C@H](C)[C@H](C)CC2=CC(OC)=C(OC)C(OC)=C2C2=C1C=C(OC)C(OC)=C2OC JEJFTTRHGBKKEI-OKILXGFUSA-N 0.000 description 3
- JEJFTTRHGBKKEI-UHFFFAOYSA-N deoxyschizandrin Natural products C1C(C)C(C)CC2=CC(OC)=C(OC)C(OC)=C2C2=C1C=C(OC)C(OC)=C2OC JEJFTTRHGBKKEI-UHFFFAOYSA-N 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- 230000007062 hydrolysis Effects 0.000 description 3
- 238000006460 hydrolysis reaction Methods 0.000 description 3
- 239000002674 ointment Substances 0.000 description 3
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 3
- 235000010234 sodium benzoate Nutrition 0.000 description 3
- 239000004299 sodium benzoate Substances 0.000 description 3
- 241000736075 Schisandra Species 0.000 description 2
- 235000008422 Schisandra chinensis Nutrition 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 238000000889 atomisation Methods 0.000 description 2
- 230000004071 biological effect Effects 0.000 description 2
- -1 drying lets cool Substances 0.000 description 2
- 238000004128 high performance liquid chromatography Methods 0.000 description 2
- 239000012567 medical material Substances 0.000 description 2
- 230000000087 stabilizing effect Effects 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Natural products OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- WQZGKKKJIJFFOK-UHFFFAOYSA-N alpha-D-glucopyranose Natural products OCC1OC(O)C(O)C(O)C1O WQZGKKKJIJFFOK-UHFFFAOYSA-N 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- XJCRCPKBJWRZAX-UHFFFAOYSA-L disodium;dibenzoate Chemical compound [Na+].[Na+].[O-]C(=O)C1=CC=CC=C1.[O-]C(=O)C1=CC=CC=C1 XJCRCPKBJWRZAX-UHFFFAOYSA-L 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 210000004211 gastric acid Anatomy 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 206010027175 memory impairment Diseases 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 229960003742 phenol Drugs 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- DKVBOUDTNWVDEP-NJCHZNEYSA-N teicoplanin aglycone Chemical compound N([C@H](C(N[C@@H](C1=CC(O)=CC(O)=C1C=1C(O)=CC=C2C=1)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)OC=1C=C3C=C(C=1O)OC1=CC=C(C=C1Cl)C[C@H](C(=O)N1)NC([C@H](N)C=4C=C(O5)C(O)=CC=4)=O)C(=O)[C@@H]2NC(=O)[C@@H]3NC(=O)[C@@H]1C1=CC5=CC(O)=C1 DKVBOUDTNWVDEP-NJCHZNEYSA-N 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8988—Gastrodia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/79—Schisandraceae (Schisandra family)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8968—Ophiopogon (Lilyturf)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
The present invention relates to the field of Chinese medicines, particularly relate to a kind of preparation method of compound tall gastrodia tuber preparation and the compound tall gastrodia tuber preparation of acquisition.Preparation method of the present invention with Rhizoma Gastrodiae, Fructus Schisandrae Chinensis, Radix Ophiopogonis for effective ingredient, with the heavy percolation Rhizoma Gastrodiae of the ethanol of 70%-80% volume fraction, with the alcohol reflux Fructus Schisandrae Chinensis of 85%-95% volume fraction, Radix Ophiopogonis soak by water, concentrated filtrate after filtering respectively, dry the first dry cream, second dry cream and the 3rd dry cream, by the first dry cream after drying, second dry cream and the 3rd dry cream are pulverized and mixed respectively, add ethanol and make granule, drying, add appropriate amount of auxiliary materials mix homogeneously, filled hard capsules or enteric coated capsule get product; This obtained preferred dosage form of compound tall gastrodia tuber preparation is hard capsule or enteric coated capsule.Preparation method of the present invention solves the difficult problem that gastrodine is easily degraded, and reduces adjuvant as the use of dextrin, sucrose, improves the curative effect of medicine, be conducive to large-scale promotion and application.
Description
Technical field
The present invention relates to the field of Chinese medicines, particularly relate to a kind of preparation method of compound tall gastrodia tuber preparation and obtain compound tall gastrodia tuber preparation.
Background technology
Compound gastrodia elata medicine mainly contains the effect for the treatment of invigorating brain and relieving mental uneasiness, is usually used in the symptoms such as the giddy headache that insomnia forgetfulness and neurasthenic patient and hypertension cause.Compound gastrodia elata medicine common is at present all with Rhizoma Gastrodiae, Fructus Schisandrae Chinensis, Radix Ophiopogonis three, taste medical material formed by extracting exquisiteness, Rhizoma Gastrodiae and Fructus Schisandrae Chinensis mainly use alcohol steep three times, each extraction time is 24 hours, merge lixiviating solution, normal pressure is adopted to reclaim ethanol immersion, Radix Ophiopogonis mainly extracts 2 times with water boil, each extraction 2 hours, obtain decoction liquor Radix Ophiopogonis, merge reclaim the extracting solution after ethanol and Radix Ophiopogonis decoction liquor, simmer down to is condensed into fluid extract, add 50% appropriate aqueous sodium glycerophosphate, sodium benzoate, sucrose and dextrin, drying lets cool, spray into Fructus Citri Limoniae essence, sodium glycerophosphate, dextrin, sucrose, granule made by the adjuvants such as sodium benzoate sodium, this preparation technology concentrated extracting solution under constant-pressure and high-temperature condition can reduce the content of gastrodine, also because gastrodine composition is 4-methylol benzene-β-D-pyranglucoside semihydrate, unstable under acidic condition, aglycon is easily hydrolyzed to para hydroxybenzene ketone and D-Glucopyranose., lose activity, gastrodine facile hydrolysis, reduce the original biological activity of gastrodine, reduce quality and the curative effect of medicine, simultaneously, in preparation process, add the adjuvant such as a large amount of sucrose and dextrin, be unfavorable for the use of hyperglycemic patients, easily there is the untoward reaction of medicine, increase the risk of side effects of pharmaceutical drugs, limit its scope of application.
In order to solve the problem, those skilled in the art constantly studies new extraction preparation method, Chinese patent CN102824550A discloses a kind of manufacture method of compound tall gastrodia tuber preparation, the method is according to given drug weight and composition, by Rhizoma Gastrodiae and Fructus Schisandrae Chinensis alcohol reflux, the rear concentrated extracting solution of filtration obtains the first thick paste and drying obtains the first dry cream, then will decoct with water Radix Ophiopogonis, condensed water decoction liquor second thick paste drying obtains the second dry cream after filtering, first dry cream and the second dry cream add ethanol and are mixed and made into preparation, although the method is concentrated is adopt decompression method, improve the stability of the Chinese medicinal ingredients such as gastrodine, maintain the biological activity of the active ingredient of each medical material in prescription, improve the curative effect of medicine, this preparation method reduces a large amount of adjuvant and antiseptic that use in existing Technology, substantially increase the safety that medicine is taken, avoid the shortcoming that hyperglycemic patients can not take the agent of prior art medicine particle, there is the crowd's of taking advantage widely, but adopt the method Rhizoma Gastrodiae not to be described, Fructus Schisandrae Chinensis and Radix Ophiopogonis etc. raw material and ethanol consumption, and there is no the concentration of clear and definite ethanol, not there is practical significance, the Rhizoma Gastrodiae extracted and the effective ingredient of Fructus Schisandrae Chinensis insufficient, the Rhizoma Gastrodiae precisely do not extracted due to extracting solution consumption and the effective ingredient of Fructus Schisandrae Chinensis insufficient, cause concentration difficulty large, it is low that the compound tall gastrodia tuber preparation drawn effectively is divided into content, reduce the curative effect of medicine, be unfavorable for the promotion and application of this medicine.
Summary of the invention
Greatly and accurate in order to solve above extracting solution consumption, extracts active ingredients is insufficient, the shortcoming that gastrodine is easily degraded.The invention provides a kind of preparation method of compound tall gastrodia tuber preparation and obtain compound tall gastrodia tuber preparation, applicant through constantly determine the raw materials such as Rhizoma Gastrodiae, Fructus Schisandrae Chinensis and Radix Ophiopogonis and ethanol optimum amount, simultaneously, show that the ethanol of optimal volume mark can abundant effective component extracting through countless experiments, reduce the hydrolysis of gastrodine in producing process, ensure that quality and the curative effect of medicine.
An object of the present invention is to provide a kind of preparation method of compound tall gastrodia tuber preparation, this compound tall gastrodia tuber preparation contain Rhizoma Gastrodiae, Fructus Schisandrae Chinensis, Radix Ophiopogonis composition, described preparation method comprises the following steps:
(1) Rhizoma Gastrodiae extracts: take 10kg Rhizoma Gastrodiae, Rhizoma Gastrodiae powder is broken into coarse powder, add the ethanol percolation of 70%-80% volume fraction, the addition (L) of ethanol is 4-5 times of Rhizoma Gastrodiae gross mass (KG), filter to obtain ethanol percolation liquid, repeat percolation 3 times, merge percolate;
By above-mentioned ethanol percolation liquid decompression recycling ethanol, obtain the first thick paste;
(2) Fructus Schisandrae Chinensis extracts: take 5kg Fructus Schisandrae Chinensis, Fructus Schisandrae Chinensis powder is broken into coarse powder, adds the ethanol of 85%-95% volume fraction, the addition (L) of ethanol is 6 times of the gross mass (KG) of Fructus Schisandrae Chinensis, reflux, extract, 2-3h, filters to obtain ethanol extract;
By above-mentioned ethanol extract decompression recycling ethanol and concentrated ethanol extract, obtain the second thick paste;
(3) extract Radix Ophiopogonis: take 10kg Radix Ophiopogonis, add the 4-7 soak by water doubly of quality Radix Ophiopogonis (KG), heat cycles decocts 2-3h, filters to obtain water decoction, and heating decoction 3 times, merges water decoction;
Concentrated above-mentioned water decoction, the relative density to 1.25 of condensed water decoction liquor at 60 DEG C, adds the sodium glycerophosphate of 50%, obtains the 3rd thick paste;
(4) dry: the first thick paste, the second thick paste and the 3rd thick paste to be carried out drying under reduced pressure or spraying dry respectively, obtains the first dry cream, the second dry cream and the 3rd dry cream;
Drying under reduced pressure: the first thick paste, the second thick paste and the 3rd thick paste, put into an airtight decompression dry device, carry out decompression of bleeding, when temperature is at 55-65 DEG C, the vacuum of sealing decompression dry device is when reaching 360-600Mpa, dry the first dry cream, the second dry cream and the 3rd dry cream;
Spraying dry: the first thick paste, the second thick paste and the 3rd thick paste, put into drying device, carries out atomization heating, when temperature is at 60-90 DEG C, when the vacuum of sprayer unit reaches 260-560MPa, dry the first dry cream, the second dry cream and the 3rd dry cream;
(5) mix: the first dry cream obtained above, the second dry cream and the 3rd dry cream are ground into 100 order fine powders respectively, fine powder is mixed, add the ethanol of 40%-60% volume fraction, the interpolation volume (L) of ethanol is 0.1-0.2 times of fine powder gross mass (KG) after mixing, reduces pressure or spraying dry after mixing under 40-60 DEG C of condition, manufactures granulating, add the 0.3-0.8% magnesium stearate mixing of fine powder gross mass, load hard capsule or enteric coated capsule, blister package, obtains compound tall gastrodia tuber preparation.
Compound tall gastrodia tuber preparation of the present invention extracts respectively three kinds of materials, Rhizoma Gastrodiae adopts Repercolation method to extract, Repercolation method has solvent load few, utilization rate is high, in percolate, effective ingredient concentration is high, avoid effective ingredient decomposes goods and can send out loss, avoid gastrodine and meet water degraded, the phenomenon of pyrolytic; Fructus Schisandrae Chinensis adopts solvent extraction method, and concentration of alcohol has extracted conclusive effect to deoxyschizandrin, and when concentration of alcohol is 85%-95%, deoxyschizandrin yield is the highest, and this process stabilizing is feasible, and simple to operate, practicalness is strong; Radix Ophiopogonis adopts decocting method, repeatedly extracts, sufficient effective component extracting.
The drying condition of this technique the best is drying under reduced pressure: the first thick original text, second thick paste or the 3rd dry cream, put into an airtight decompression dry device, carry out decompression of bleeding, when temperature is at 60 DEG C, when the vacuum of sealing decompression dry device reaches 420Mpa, dry the first dry original text, second dry cream or the 3rd dry cream, spraying dry: the first thick original text, second thick paste or the 3rd dry cream, put into drying device, carry out atomization heating, when temperature is at 75 DEG C, when the vacuum of sprayer unit reaches 400MPa, dry the first dry cream, second dry cream or the 3rd dry cream, at the first dry cream that above-mentioned condition is obtained, second dry cream or the 3rd dry cream are best.And the use of adjuvant as dextrin, sucrose is deducted in preparation, improve the curative effect of medicine; Solve the shortcoming that hyperglycemic patients can not be taken, avoid the generation of adverse effect simultaneously, make medicine more safe and effective; Expand patient medication crowd, and this technique does not add the use as antiseptic such as sodium benzoate in preparation process, what improve medicine takes safety, advantageously in the safety ensureing patient medication.
Two of object of the present invention is the compound tall gastrodia tuber preparations obtained according to above-mentioned preparation method, its oral type processed is hard capsule, enteric coated capsule, pill, soft capsule, granule, powder, unguentum, tablet, wherein preferred port system of mourning type is hard capsule, enteric coated capsule, hard capsule and enteric coated capsule are packed perfect, effectively reduce the moisture absorption of medicine, substantially increase the quality stability of medicine, facilitate taking and carrying of patient, substantially increase the compliance of patient consumes.
Compared with prior art, the preparation method of compound tall gastrodia tuber preparation provided by the invention has the following advantages:
(1) compound tall gastrodia tuber preparation preparation method of the present invention, often kind of material extracts respectively, leaching process simple and feasible, has higher controllability, the hydrolysis decreasing Gastrodia gastrodine and the deoxyschizandrin extracted efficiently in Fructus Schisandrae Chinensis, ensure that the drug effect of compound gastrodia elata;
(2) compound tall gastrodia tuber preparation preparation method of the present invention, is prepared into hard capsule or enteric coated capsule, makes the effective ingredient of compound gastrodia elata medicine not be vulnerable to the effect of gastric acid and be hydrolyzed, while ensure that pharmaceutical effectiveness, is convenient to take;
(3) compound tall gastrodia tuber preparation preparation method of the present invention does not add adjuvant and antiseptic, and such as, sucrose, sodium benzoate etc., improve the safety that medicine is taken, and avoids the shortcoming that hyperglycemic patients can not take existing granules medicine.
Detailed description of the invention
The present invention is further illustrated below by way of specific embodiment; but those skilled in the art should know specific embodiments of the invention and not limit the present invention in any way, and any equivalent replacement done on basis of the present invention all falls into protection scope of the present invention.
embodiment 1,a kind of preparation method of compound tall gastrodia tuber preparation:
(1) Rhizoma Gastrodiae extracts: take 10kg Rhizoma Gastrodiae, Rhizoma Gastrodiae powder is broken into coarse powder, add the ethanol percolation that 50L volume fraction is 70%, filter to obtain ethanol percolation liquid, repeats percolation 3 times, merges percolate;
By above-mentioned ethanol percolation liquid decompression recycling ethanol, obtain the first thick paste;
(2) Fructus Schisandrae Chinensis extracts: take 5kg Fructus Schisandrae Chinensis, Fructus Schisandrae Chinensis powder is broken into coarse powder, add the ethanol that 30L volume fraction is 85%, reflux, extract, 3h, filter to obtain ethanol extract;
By above-mentioned ethanol extract decompression recycling ethanol and concentrated ethanol extract, obtain the second thick paste;
(3) extract Radix Ophiopogonis: take 10kg Radix Ophiopogonis, add 50L soak by water, heat cycles decocts 3h, filters to obtain water decoction, and heating decoction 3 times, merges water decoction;
Concentrated above-mentioned water decoction, the relative density to 1.25 of condensed water decoction liquor at 60 DEG C, adds the sodium glycerophosphate of 50%, obtains the 3rd thick paste;
(4) drying under reduced pressure: the first thick paste, the second thick paste and the 3rd thick paste, put into an airtight decompression dry device, carry out decompression of bleeding, when temperature is at 60 DEG C, the vacuum of sealing decompression dry device is when reaching 420Mpa, dry the first dry cream, the second dry cream and the 3rd dry cream;
(5) mix: the first dry cream obtained above, the second dry cream and the 3rd dry cream are ground into 100 order fine powders respectively, fine powder is mixed, add the ethanol that volume fraction is 40%, the interpolation volume (L) of ethanol is 0.2 times of fine powder gross mass (KG) after mixing, reduces pressure or spraying dry after mixing under 40 DEG C of conditions, manufactures granulating, add the mixing of fine powder gross mass 0.5% magnesium stearate, load hard capsule or enteric coated capsule, blister package, obtains compound tall gastrodia tuber preparation.
embodiment 2,a kind of preparation method of compound tall gastrodia tuber preparation:
(1) Rhizoma Gastrodiae extracts: take 10kg Rhizoma Gastrodiae, Rhizoma Gastrodiae powder is broken into coarse powder, add the ethanol percolation that 50L volume fraction is 75%, filter to obtain ethanol percolation liquid, repeats percolation 3 times, merges percolate;
By above-mentioned ethanol percolation liquid decompression recycling ethanol, obtain the first thick paste;
(2) Fructus Schisandrae Chinensis extracts: take 5kg Fructus Schisandrae Chinensis, Fructus Schisandrae Chinensis powder is broken into coarse powder, add the ethanol that 30L volume fraction is 90%, reflux, extract, 2h, filter to obtain ethanol extract;
By above-mentioned ethanol extract decompression recycling ethanol and concentrated ethanol extract, obtain the second thick paste;
(3) extract Radix Ophiopogonis: take 10kg Radix Ophiopogonis, add 50L soak by water, heat cycles decocts 3h, filters to obtain water decoction, and heating decoction 3 times, merges water decoction;
Concentrated above-mentioned water decoction, the relative density to 1.25 of condensed water decoction liquor at 60 DEG C, adds the sodium glycerophosphate of 50%, obtains the 3rd thick paste;
(4) drying under reduced pressure: the first thick paste, the second thick paste and the 3rd thick paste, put into an airtight decompression dry device, carry out decompression of bleeding, when temperature is at 60 DEG C, the vacuum of sealing decompression dry device is when reaching 420Mpa, dry the first dry cream, the second dry cream and the 3rd dry cream;
(5) mix: the first dry cream obtained above, the second dry cream and the 3rd dry cream are ground into 100 order fine powders respectively, fine powder is mixed, add the ethanol that volume fraction is 50%, the interpolation volume of ethanol is 0.2 times of fine powder gross mass after mixing, reduces pressure or spraying dry after mixing under 40 DEG C of conditions, manufactures granulating, add the mixing of fine powder gross mass 0.5% magnesium stearate, load hard capsule or enteric coated capsule, blister package, obtains compound tall gastrodia tuber preparation.
embodiment 3,a kind of preparation method of compound tall gastrodia tuber preparation:
(1) Rhizoma Gastrodiae extracts: take 10kg Rhizoma Gastrodiae, Rhizoma Gastrodiae powder is broken into coarse powder, add the ethanol percolation that 50L volume fraction is 80%, filter to obtain ethanol percolation liquid, repeats percolation 3 times, merges percolate;
By above-mentioned ethanol percolation liquid decompression recycling ethanol, obtain the first thick paste;
(2) Fructus Schisandrae Chinensis extracts: take 5kg Fructus Schisandrae Chinensis, Fructus Schisandrae Chinensis powder is broken into coarse powder, add the ethanol that 30L volume fraction is 95%, reflux, extract, 2h, filter to obtain ethanol extract;
By above-mentioned ethanol extract decompression recycling ethanol and concentrated ethanol extract, obtain the second thick paste;
(3) extract Radix Ophiopogonis: take 10kg Radix Ophiopogonis, add 50L soak by water, heat cycles decocts 3h, filters to obtain water decoction, and heating decoction 3 times, merges water decoction;
Concentrated above-mentioned water decoction, the relative density to 1.25 of condensed water decoction liquor at 60 DEG C, adds the sodium glycerophosphate of 50%, obtains the 3rd thick paste;
(4) drying under reduced pressure: the first thick paste, the second thick paste and the 3rd thick paste, put into an airtight decompression dry device, carry out decompression of bleeding, when temperature is at 60 DEG C, the vacuum of sealing decompression dry device is when reaching 420Mpa, dry the first dry cream, the second dry cream and the 3rd dry cream;
(5) mix: the first dry cream obtained above, the second dry cream and the 3rd dry cream are ground into 100 order fine powders respectively, fine powder is mixed, add the ethanol that volume fraction is 60%, the interpolation volume of ethanol is 0.2 times of fine powder gross mass after mixing, reduces pressure or spraying dry after mixing under 40 DEG C of conditions, manufactures granulating, add the mixing of fine powder gross mass 0.5% magnesium stearate, load hard capsule or enteric coated capsule, blister package, obtains compound tall gastrodia tuber preparation.
comparative example one,a kind of manufacture method of compound tall gastrodia tuber preparation:
(1) extract: take Rhizoma Gastrodiae 100g, Fructus Schisandrae Chinensis 50g, add the alcohol reflux 5h of 50% volume fraction of 5 times amount volumes (ml) of Rhizoma Gastrodiae and schisandra raw material gross mass (g), excess ethanol extracting solution, decompression recycling ethanol and concentrated extracting solution, the relative density to 1.25 of concentrated extracting solution at 60 DEG C, obtains the first thick paste;
Take 100g Radix Ophiopogonis, the distilled water adding the 5 times amount volumes (ml) of quality Radix Ophiopogonis (g) decocts 6h Radix Ophiopogonis, filter distilled water decoction liquor and concentrated distilled water decoction liquor, add aqueous sodium glycerophosphate, at 60 DEG C, the relative density to 1.25 of concentrated extracting solution obtains the second thick paste;
(2) dry: the first thick paste and the second thick paste to be carried out drying under reduced pressure or spraying dry respectively, obtains the first dry cream and the second dry cream;
(3) mix: pulverize after the first dry cream and the second dry cream mixing, after adding mixing, the ethanol of 0.2 times amount volume 50% volume fraction of raw material gross mass is mixed into ointment and drying under reduced pressure or spraying dry, makes preparation.
comparative example two,a kind of manufacture method of compound tall gastrodia tuber preparation:
(1) extract: take Rhizoma Gastrodiae 10kg, Fructus Schisandrae Chinensis 5kg, add the alcohol reflux 5h of 50% volume fraction of 5 times amount volumes (L) of Rhizoma Gastrodiae and schisandra raw material gross mass (KG), excess ethanol extracting solution, decompression recycling ethanol and concentrated extracting solution, the relative density to 1.25 of concentrated extracting solution at 60 DEG C, obtains the first thick paste;
Take 10kg Radix Ophiopogonis, the distilled water adding 5 times amount volumes (L) of quality Radix Ophiopogonis (KG) decocts 6h Radix Ophiopogonis, filter distilled water decoction liquor and concentrated distilled water decoction liquor, add aqueous sodium glycerophosphate, at 60 DEG C, the relative density to 1.25 of concentrated extracting solution obtains the second thick paste;
(2) dry: the first thick paste and the second thick paste to be carried out drying under reduced pressure or spraying dry respectively, obtains the first dry cream and the second dry cream;
(3) mix: pulverize after the first dry cream and the second dry cream mixing, after adding mixing, the ethanol of 0.2 times amount volume 50% volume fraction of raw material gross mass is mixed into ointment and drying under reduced pressure or spraying dry, makes preparation.
experimental example one,compound tall gastrodia tuber preparation gastrodine high performance liquid chromatography (HPLC) assay result of the present invention:
High performance liquid chromatography is with reference to the assay method of " Chinese Pharmacopoeia version in 2010 annex VID ":
The assay of the gastrodine of table 1, embodiment of the present invention 1-3 and comparative example one and comparative example two:
From above-mentioned table 1, the effective ingredient that the preparation method of compound tall gastrodia tuber preparation of the present invention is extracted is all high than the content of comparative example one, and this process stabilizing is feasible, result is more stable, repeatability is stronger, is more conducive to suitability for industrialized production, especially best with embodiment 2.And by comparative example two (by unconventional and unrestrained for comparative example one technique to suitability for industrialized production time) find, the content of gastrodine is reduced to 0.92% by 1.20%, as can be seen here the unsuitable suitability for industrialized production of the technique of comparative example one.
Claims (2)
1. a preparation method for compound tall gastrodia tuber preparation, is characterized in that, described preparation method comprises the following steps:
(1) Rhizoma Gastrodiae extracts: take 10kg Rhizoma Gastrodiae, Rhizoma Gastrodiae powder is broken into coarse powder, add the ethanol percolation of 75% volume fraction, the addition of ethanol is 50L, filters to obtain ethanol percolation liquid, repeats percolation 3 times, merges percolate; By above-mentioned ethanol percolation liquid decompression recycling ethanol, obtain the first thick paste;
(2) Fructus Schisandrae Chinensis extracts: take 5kg Fructus Schisandrae Chinensis, Fructus Schisandrae Chinensis powder is broken into coarse powder, add the ethanol of 90% volume fraction, the addition of ethanol is 30L, and reflux, extract, 2h filters to obtain ethanol extract; By above-mentioned ethanol extract decompression recycling ethanol and concentrated ethanol extract, obtain the second thick paste;
(3) extract Radix Ophiopogonis: take 10kg Radix Ophiopogonis, add 50L soak by water, heat cycles decocts 3h, filters to obtain water decoction, and heating decoction 3 times, merges water decoction; Concentrated above-mentioned water decoction, the relative density to 1.25 of condensed water decoction liquor at 60 DEG C, adds the sodium glycerophosphate of 50%, obtains the 3rd thick paste;
(4) drying under reduced pressure: the first thick paste, the second thick paste and the 3rd thick paste, put into an airtight decompression dry device, carry out decompression of bleeding, when temperature is at 60 DEG C, the vacuum of sealing decompression dry device is when reaching 420mpa, dry the first dry cream, the second dry cream and the 3rd dry cream;
(5) mix: the first dry cream obtained above, the second dry cream and the 3rd dry cream are ground into 100 order fine powders respectively, fine powder is mixed, add the ethanol of 50% volume fraction, the interpolation volume of ethanol is 0.2 times of fine powder gross mass after mixing, reduces pressure or spraying dry after mixing under 40 DEG C of conditions, manufactures granulating, add the mixing of fine powder gross mass 0.5% magnesium stearate, load hard capsule or enteric coated capsule, blister package, obtains compound tall gastrodia tuber preparation.
2. the compound tall gastrodia tuber preparation that the preparation method of compound tall gastrodia tuber preparation as claimed in claim 1 is obtained.
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| CN102824550A (en) * | 2012-09-14 | 2012-12-19 | 昭通市骅成制药有限公司 | Method for preparing compound gastrodia elata preparation |
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| CN102824550A (en) * | 2012-09-14 | 2012-12-19 | 昭通市骅成制药有限公司 | Method for preparing compound gastrodia elata preparation |
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| 复方天麻咀嚼片提取工艺研究;万军等;《中成药》;20090731;第31卷(第7期);第1110-1111页 * |
| 高效液相色谱法优选五味子浸膏的提取工艺;田振坤等;《中医药学报》;20091231;第37卷(第2期);第43-45页 * |
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