CN103598590B - Traditional Chinese medicine composition for decreasing blood sugar and application thereof - Google Patents
Traditional Chinese medicine composition for decreasing blood sugar and application thereof Download PDFInfo
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- A—HUMAN NECESSITIES
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
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- A—HUMAN NECESSITIES
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- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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Abstract
The invention relates to a traditional Chinese medicine composition for decreasing blood sugar and application thereof. The composition comprises the following components in parts by weight: 5 to 10 parts of scrophularia ningpoensis, 10 to 24 parts of astragalus membranaceus, 30 to 38 parts of radix puerariae, 30 to 40 parts of rhizoma polygonati, and 10 to 25 parts of lithocarpus polystachyus leaves. The preparation method of the traditional Chinese medicine composition comprises the step of superfine grinding by which the effective ingredients can be quickly dissolved out and absorbed by a human body. The traditional Chinese medicine composition has the effects of assisting to decrease blood sugar, comprehensively regulating physical function, treating both symptoms and root causes, and consolidating the effect.
Description
Technical field
The invention belongs to Chinese medicine health-care technical field, be specifically related to one and fall hypoglycemic Chinese medicine composition and application thereof.
Background technology
Diabetes a kind ofly increase endocrine and metabolic disorders disease for feature with plasma glucose levels, be a kind ofly to interact with inherent cause and environmental factor, the multifactor disease jointly caused.Clinically, diabetes show typical three-many-one-little symptom, i.e. many drinks, diuresis, the symptom of eating more and losing weight, and the various complication caused by it have become that patient is disabled, lethal one of the main reasons.This disease is difficult to cure, needs of patients Long-term taking medicine, maintains blood sugar in normal range (NR) or stop blood sugar to raise further, delay increasing the weight of and the generation of complication of the state of an illness by medicine.
At present, the treatment of diabetes is main mainly with Western medicine, as sulfonylureas and biguanides, although hypoglycemic effect is rapid, act on single, increase pancreas islet burden, and there is the side effect such as hypoglycemia, gastrointestinal reaction, along with the prolongation for the treatment of time, hypoglycemic effect is reduction trend, and long-term taking also can cause liver kidney toxic and side effect.
Theory of traditional Chinese medical science thinks that diabetes spp is in category of quenching one's thirst, its interpretation of the cause, onset and process of an illness be mainly lung, stomach, the dirty the moon of kidney three thanks to scorching, calcination body fluid, disappear caused by bright water paddy.Chinese traditional herbs treatment diabetes action temperature and lasting, side effect is little, and the mechanism of action has Mutiple Targets, manifold effect, multi-functional Comprehensive Characteristics.
If filter out from Chinese medicine effectively, the hypoglycemic medicinal material of safety and par, be made into the formulation conveniently taken, take while other medicines treatment diabetes, can play assistant hypoglycemic, comprehensively regulating physical function, treats both principal and secondary aspect of disease, the effect of consolidate curative effect.
Summary of the invention
In view of this, the object of the present invention is to provide one to fall hypoglycemic Chinese medicine composition, said composition can play assistant hypoglycemic, comprehensively regulating physical function, treats both principal and secondary aspect of disease, the effect of consolidate curative effect.
For solving the problems of the technologies described above, the technical solution used in the present invention is:
Of the present inventionly fall hypoglycemic Chinese medicine composition, comprise the component of following weight proportion: radix scrophulariae 5 ~ 10 parts, the Radix Astragali 10 ~ 24 parts, the root of kudzu vine 30 ~ 38 parts, sealwort 30 ~ 40 parts, manyspike tanoak leaf 10 ~ 25 parts.
Further, of the present inventionly fall hypoglycemic Chinese medicine composition, preferably include the component of following weight proportion: radix scrophulariae 6 ~ 7 parts, the Radix Astragali 13 ~ 17 parts, the root of kudzu vine 32 ~ 36 parts, sealwort 34 ~ 36 parts, manyspike tanoak leaf 20 ~ 24 parts.Describedly fall hypoglycemic Chinese medicine composition, more preferably comprise the component of following weight proportion: radix scrophulariae 7 parts, the Radix Astragali 17 parts, the root of kudzu vine 32 parts, sealwort 34 parts, manyspike tanoak leaf 24 parts.
Above-mentioned composition is in a particular application, different depending on concrete dosage form, also can add filler, cosolvent, flavouring, bacteriostatic agent etc.
According to " Chinese medicine voluminous dictionary " (Nanjing University of Traditional Chinese Medicine writes, Shanghai science tech publishing house, the second edition), the mechanism of described five tastes raw medicinal material is as follows: radix scrophulariae, return lung, stomach, kidney channel, there is cool blood, nourishing Yin and falling fire, effect of removing toxic substances, warm heat disease heat can be treated and enter ying blood, body heat, polydipsia, tongue is deep red, and send out spot, hectic fever due to yin labor is coughed, dysphoria is insomnia, and constipation is hindered in Tianjin, and order is puckery dim-sighted, abscess of throat, scrofula subcutaneous nodule, skin sore etc.The Radix Astragali, returns lung, the spleen channel, has invigorating qi for strengthening superficies, diuresis holder poison, apocenosis, and expelling pus and promoting granulation is weak for the deficiency of vital energy, anorexia and loose stool, and the sinking of qi of middle-jiao, rushes down prolapse of the anus for a long time, uterine bleeding of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy oedema, and ulcer difficulty is burst, and burst for a long time and do not hold back, flaccidity of limbs due to deficiency of blood is yellow, and interior heat is quenched one's thirst; Chronic rephrilis protinuria, diabetes.Sealwort, returns spleen, stomach warp, has Yin nourishing and lung moistening, invigorate the spleen and benefit qi, effect of Zishen fill fine, can treat deficiency of Yin labor and cough, xeropulmonary cough; Insufficiency of the spleen weak, the few dry of food, quenches one's thirst; Deficiency of the kidney soreness and weakness of waist and knees, impotence and seminal emission, tinnitus order is dark, poliosis, and body void is won thin, wind favus disease etc.The root of kudzu vine, returns spleen, stomach warp, has expelling pathogenic factors from muscles and skin and deliver, promote the production of body fluid to quench thirst, rise effect of positive antidiarrheal, cure mainly fever caused by exogenous pathogens, rigid and painful head and neck, and measles goes out smooth from the beginning of, rash, warm disease is thirsty, diabete, has loose bowels, dysentery etc.Manyspike tanoak leaf, has clearing heat and detoxicating, reduces phlegm, dispel the wind, step-down, main damp-heat dysentery, cough with lung heat, ulcer sores, pruitus, hypertension.
Described gomi herbs weight proportion in the composition, with the prepared slices of Chinese crude drugs through concocting for benchmark.Said composition, when embody rule, can adopt traditional decoction form, also can be used as functional materials and adds in health food, also can be prepared as the preparation being easy to preserve and take.Another order of the present invention is just that protection is of the present invention and falls hypoglycemic Chinese medicine composition and preparing the application in Chinese medicine preparation or health products.Particularly, the formulation of described preparation is pill, powder, tablet, capsule, granule, paste, oral liquid etc.
There is provided a kind of below the present invention and utilize the above-mentioned method of falling hypoglycemic Chinese medicine composition and preparing preparation, the method is conducive to the stripping of each medicinal material active ingredient in composition, and extraction efficiency is high, and the concentrate of preparation is also convenient to further preparation.
For solving the problems of the technologies described above, the technical solution used in the present invention is:
Fall the method that hypoglycemic Chinese medicine composition prepares preparation, comprise the following steps:
A, get the prepared slices of Chinese crude drugs respectively ultramicro grinding of manyspike tanoak leaf, radix scrophulariae, the Radix Astragali, the root of kudzu vine and sealwort, obtain medicinal powder;
B, by the above-mentioned weight proportion falling hypoglycemic Chinese medicine composition, the medicinal powder getting steps A carries out ultrasonic wave or microwave radiation exaraction, obtains extract;
C, the extract getting step B carry out filtering with microporous membrane, concentrated, obtain concentrate for preparation and get final product.
Further, the preparation method of the prepared slices of Chinese crude drugs of described radix scrophulariae, the Radix Astragali, the root of kudzu vine and sealwort comprises the following steps: the fresh medicinal material getting radix scrophulariae, the Radix Astragali, the root of kudzu vine and sealwort, through cleaning, drying, stripping and slicing, after degreasing, dries obtained.
Further, described steps A is by medicine materical crude slice ultramicro grinding to 200 order or thinner.
Ultramicro grinding described in steps A refers to that utilizing machinery or hydrokinetic method to overcome solid interior cohesiveness makes it broken, material particles more than millimeter can be crushed to the operating technology of micron, the powder obtained thus has good dissolubility, dispersiveness, adsorptivity, chemical reactivity etc.Superfine communication technique is used for the present invention, thus obtained drug powder, being directly used in preparation has good formulation properties, and for further extraction, extracted amount and the extraction efficiency of its active component also increase.
In above-mentioned preparation method, extract again after ultramicro grinding, can extraction efficiency be improved, increase the stripping of active component; And when preparing the prepared slices of Chinese crude drugs, ungrease treatment is carried out to medicinal material, be then conducive to the carrying out of ultramicro grinding.During concrete crushing operation, after can first tentatively pulverizing with common grinder, then be crushed to required granularity with micronizer.
It is the special roles such as the cavitation utilizing ultrasonic wave to produce that ultrasonic wave described in step B extracts, one that chemical composition contained in medicine is extracted quickly and efficiently new extractive technique.Its operating process is: add in a reservoir and extract solvent (water, ethanol or other organic solvents etc.), Chinese medicine is pulverized or is cut into graininess as required, puts into and extracts solvent; The bonding transducer oscillator of outer wall of container or oscillator is sealed in stainless steel box drops in container; Open supersonic generator, oscillator sends ultrasonic wave in extraction solvent, ultrasonic wave extract in solvent ' cavitation effect ' that produce and mechanism one side can the cell membrane of broken medicinal material effectively, make active ingredient be free state and dissolve in extract in solvent, the molecular motion of extracting solvent can be accelerated on the other hand, make to extract the active ingredient Rapid contact in solvent and medicinal material, mutually fused, mixing.Ultrasonic wave extracts the extraction low with its Extracting temperature, recovery rate is high, extraction time is short unique advantage is widely used in Chinese medicine and various animal and plant effective content, is to substitute tradition to shear the modern high technology means that process realization is efficient, energy-saving and environmental protection formula is extracted.Described microwave auxiliary extraction (MAE), i.e. microwave abstracting, that the difference absorbing microwave ability according to different material makes some component in some region of base matter or extraction system by selective heating, thus make to be extracted material and be separated from matrix or system, enter into that dielectric constant is less, the extractant of microwave absorption capacity relative mistake, reach the object of extraction.The present invention adopts ultrasonic wave or microwave radiation exaraction, due to the advantage of the method itself, and the synergy of the present composition in leaching process, recovery rate and extraction efficiency can be significantly improved.
Filtering with microporous membrane described in step C is also known as secondary filter, mainly for separating of submicron particles, current most widely used a kind of compartment analysis subparticle and ultra-clean degerming means, have simple to operate, floor space is little, without phase transformation and can not produce the advantages such as new polluter, good separating effect in processing procedure.In method of the present invention, after first can carrying out coarse filtration to extract, carry out filtering with microporous membrane again.
Extract after filtering concentrates by modes such as atmospheric evaporation, reduction vaporization, thin film evaporation.The concentrate obtained can carry out preparation according to the conventional method of Chinese medicine preparation, finally makes the various formulations such as pill, powder, tablet, capsule, granule.According to standby concrete formulation of drawing up, necessary diluent, adhesive, disintegrant, lubricant etc. can be added.
The present invention also have an object to be providing a kind of utilizes the above-mentioned method of falling hypoglycemic Chinese medicine composition and preparing capsule, the method operation is simple, product storage and take all very convenient.The technical scheme adopted is:
Fall the method that hypoglycemic Chinese medicine composition prepares capsule, comprise the following steps:
By the above-mentioned weight proportion falling hypoglycemic Chinese medicine composition, get the prepared slices of Chinese crude drugs ultramicro grinding of manyspike tanoak leaf, radix scrophulariae, the Radix Astragali, the root of kudzu vine and sealwort respectively, cross 200 mesh sieves, obtain medicinal powder batch mixing, encapsulated, to obtain final product.
Further, the preparation method of the prepared slices of Chinese crude drugs of described radix scrophulariae, the Radix Astragali, the root of kudzu vine and sealwort comprises the following steps: the fresh medicinal material getting radix scrophulariae, the Radix Astragali, the root of kudzu vine and sealwort, through cleaning, drying, stripping and slicing, after degreasing, dries obtained.
The ultramicro grinding medicinal powder granularity that said method obtains is suitable for, and has both been conducive to the absorption of human body, has had again good mobility, be convenient to pharmaceutical practice.As the further improvement of said method, preferably capsule is prepared into the capsule containing medicinal ingredient 0.3g/ grain.
Beneficial effect of the present invention: of the present inventionly fall hypoglycemic Chinese medicine composition, follows the principle of tcm syndrome differentiation and treatment, all medicine phases and, there is nourishing kidney-YIN, fall hypoglycemic effect, integration of drinking and medicinal herbs, cheap.The medicine for the treatment of diabetes by itself and other is taken simultaneously, and particularly as adjuvant drug or the health products of chemical classes antidiabetic drug, can play assistant hypoglycemic, comprehensively regulating physical function, treats both principal and secondary aspect of disease, the effect of consolidate curative effect; For having Diabetes family history or three high diabetes vulnerable crowds, it can be used as health products to take and can play the effect preventing diabetes.This falls hypoglycemic Chinese medicine composition can be prepared as multiple formulation, and its preparation method adopts superfine communication technique again, makes the product of acquisition have good dissolubility, dispersiveness, adsorptivity, chemical reactivity etc., is easy to follow-up pharmaceutical practice and absorption of human body.Especially the capsule prepared as stated above, operation is simple, and product is stored and taken all very convenient.
Detailed description of the invention
In order to make the object, technical solutions and advantages of the present invention clearly, below the preferred embodiments of the present invention and contrast experiment's example are described in detail.
Embodiment 1
Press row weight proportion and prepare each component: radix scrophulariae 10g, Radix Astragali 24g, root of kudzu vine 30g, sealwort 30g, manyspike tanoak leaf 25g.Each component is tentatively pulverized respectively, carries out ultramicro grinding again after pulverizing, and cross 200 mesh sieves, batch mixing, is pressed into 0.25g/ sheet, film coating, obtains final product.
Embodiment 2
Press row weight proportion and prepare each component: radix scrophulariae 6g, Radix Astragali 18g, root of kudzu vine 36g, sealwort 34g, manyspike tanoak leaf 23g.Each component is tentatively pulverized respectively, carries out ultramicro grinding again after pulverizing, and cross 200 mesh sieves, batch mixing, packing, sterilizing, obtains powder.
Embodiment 3
Press row weight proportion and prepare each component: radix scrophulariae 7g, Radix Astragali 14g, root of kudzu vine 36g, sealwort 36g, manyspike tanoak leaf 22g.Each component is tentatively pulverized respectively, carries out ultramicro grinding again after pulverizing, and cross 200 mesh sieves, batch mixing, encapsulated 0.3g/ grain, to obtain final product.
Embodiment 4
Press row weight proportion and prepare each component: radix scrophulariae 5g, Radix Astragali 13g, root of kudzu vine 38g, sealwort 40g, manyspike tanoak leaf 20g.Each component is tentatively pulverized respectively, carries out ultramicro grinding again after pulverizing, and cross 200 mesh sieves, batch mixing, encapsulated 0.3g/ grain, to obtain final product.
Embodiment 5
Press row weight proportion and prepare each component: radix scrophulariae 700g, Radix Astragali 1700g, root of kudzu vine 3200g, sealwort 3400g, manyspike tanoak leaf 2400g.Each component is tentatively pulverized respectively, carries out ultramicro grinding again after pulverizing, and cross 200 mesh sieves, batch mixing, encapsulated 0.3g/ grain, to obtain final product.
Embodiment 6
Press row weight proportion and prepare each component: radix scrophulariae 500g, Radix Astragali 1000g, root of kudzu vine 3000g, sealwort 3000g, manyspike tanoak leaf 1000g.Each component is tentatively pulverized respectively, carries out ultramicro grinding again after pulverizing, and cross 200 mesh sieves, add filler starch 2900g, batch mixing, encapsulated 0.3g/ grain, to obtain final product.
Embodiment 7
Get the fresh medicinal material of radix scrophulariae, the Radix Astragali, the root of kudzu vine and sealwort, through cleaning, drying, stripping and slicing, after degreasing, dry the obtained prepared slices of Chinese crude drugs.Get the prepared slices of Chinese crude drugs of manyspike tanoak leaf again, and the prepared slices of Chinese crude drugs of aforementioned obtained radix scrophulariae, the Radix Astragali, the root of kudzu vine and sealwort ultramicro grinding respectively, obtain medicinal powder.Press row weight proportion and take each medicinal powder: radix scrophulariae 10g, Radix Astragali 24g, root of kudzu vine 30g, sealwort 30g, manyspike tanoak leaf 25g, all medicinal powder is mixed, proceeding to model is in the ultrosonic extractor of SBL-ultrasonic wave (Ningbo Xin Zhi biotechnology Co., Ltd), add water 2000ml, ultrasonic power 600W, ultrasonic extraction 1 hour.After extraction completes, suction filtration obtains filtrate, then obtains filtrate with the filtering with microporous membrane of 0.45 μm.Filtrate evaporated under reduced pressure after filtering with microporous membrane is concentrated into 500ml, adds white granulated sugar 250g, and dissolve mixing, sterilizing, obtains the syrup of this Chinese medicine composition.
Contrast experiment's example 1
Accept out-patient 150 example for medical treatment, the wherein male sex 90 people, women 60 people, 50 years old mean age, is divided into A, B1, B2, C1, C2 five groups at random, often organizes 30 people: A group, as reference group, takes starch capsule 1,3 times/day; B1 and B2 group takes the capsule 1 of embodiment 5 and embodiment 6 preparation respectively, 3 times/day; C1 and C2 group takes the capsule 2 of embodiment 5 and embodiment 6 preparation respectively, 3 times/day.
All patients take capsule continuously and stop using after 30 days, then observe 20 days.Respectively take capsule first 1 day, take capsule after within the 30th day and after taking capsule the 50th day, carry out detection fasting blood-glucose index.The surveyed index average ± standard deviation of result represents, the statistical method of application t inspection is analyzed result, and P < 0.05 thinks tool significance.Test result is as follows:
Table 1 patient takes the test result of fasting blood-glucose before and after capsule (mmol/L)
Group | Take capsule situation | Take first 1 day | Take latter 30th day | Take latter 50th day |
A group | Starch capsule 1,3 times/day | 11.9±0.8 | 12.8±1.0 | 12.9±0.8 |
B1 group | Embodiment 5 capsule 1,3 times/day | 12.0±1.1 | 8.6±1.0* | 9.6±1.4* |
B2 group | Embodiment 6 capsule 1,3 times/day | 12.1±0.9 | 9.4±1.2* | 9.9±1.6* |
C1 group | Embodiment 5 capsule 2,3 times/day | 12.2±1.3 | 8.7±1.1* | 9.8±1.5* |
C2 group | Embodiment 6 capsule 2,3 times/day | 11.9±1.0 | 8.6±0.9* | 9.5±1.3* |
Note *: with take before compare: P < 0.05, its otherness has statistical significance.
As shown in Table 1, diabetes patient is when refusing to obey other hypoglycemic medicine, only take the present invention and fall capsule prepared by hypoglycemic Chinese medicine composition, all before taking capsule, obvious decline is had at the blood glucose test result of the 30th day and the 50th day, and after drug withdrawal the 50th day, still there is not remarkable bounce-back in blood glucose test result.In addition, from the data of B1 and B2, C1 and C2, take embodiment 6, according to capsule prepared by composition minority component, still there is the curative effect suitable with embodiment 5 capsule.Therefore, of the present invention to fall hypoglycemic Chinese medicine composition curative effect reliable, has and obviously fall hypoglycemic function, has prevention effect to the generation of diabetes and development.
Contrast experiment's example 2
Accept out-patient 60 example for medical treatment, the wherein male sex 34 people, women 26 people, 50 years old mean age, is divided into A, B two groups at random, often organizes 30 people: A, B group all takes metformin hydrochloride tablet, each 0.25g, 3 times/day; B group also takes capsule 1 prepared by embodiment 5 simultaneously, 3 times/day.
All patients take capsule continuously and stop using after 30 days, then observe 20 days.Respectively take capsule first 1 day, take capsule after within the 30th day and after taking capsule the 50th day, detect, Detection of content comprises fasting blood-glucose.The surveyed index mean ± standard deviation of result represents, the statistical method of application t inspection is analyzed result, and P < 0.05 thinks tool significance.Test result is as follows:
The contrast test result of fasting blood-glucose (mmol/L) after table 2 patient in combination medication
Compare before noting * and taking: P < 0.05, its otherness has statistical significance.
As shown in Table 2, diabetes patient, when taking other hypoglycemic medicine, also takes the present invention and falls capsule prepared by hypoglycemic Chinese medicine composition, hypoglycemic effect better, more stable.
What finally illustrate is, above embodiment is only in order to illustrate technical scheme of the present invention and unrestricted, although with reference to preferred embodiment to invention has been detailed description, those of ordinary skill in the art is to be understood that, can modify to technical scheme or equivalent replacement, and not departing from aim and the scope of technical solution of the present invention, it all should be encompassed in the middle of right of the present invention.
Claims (9)
1. fall hypoglycemic Chinese medicine composition, be made up of the component of following weight proportion: radix scrophulariae 5 ~ 10 parts, the Radix Astragali 10 ~ 24 parts, the root of kudzu vine 30 ~ 38 parts, sealwort 30 ~ 40 parts, manyspike tanoak leaf 10 ~ 25 parts.
2. according to claim 1ly fall hypoglycemic Chinese medicine composition, it is characterized in that: be made up of the component of following weight proportion: radix scrophulariae 6 ~ 7 parts, the Radix Astragali 13 ~ 17 parts, the root of kudzu vine 32 ~ 36 parts, sealwort 34 ~ 36 parts, manyspike tanoak leaf 20 ~ 24 parts.
3. according to claim 1ly fall hypoglycemic Chinese medicine composition, it is characterized in that: be made up of the component of following weight proportion: radix scrophulariae 7 parts, the Radix Astragali 17 parts, the root of kudzu vine 32 parts, sealwort 34 parts, manyspike tanoak leaf 24 parts.
4. the hypoglycemic Chinese medicine composition that falls described in any one of claims 1 to 3 is preparing the application in Chinese medicine preparation or health products.
5. application according to claim 4, is characterized in that: the formulation of described preparation is pill, powder, tablet, capsule or granule.
6. utilize and fall the method that hypoglycemic Chinese medicine composition prepares preparation described in any one of claim 1 to 3, comprise the following steps:
A, get the prepared slices of Chinese crude drugs respectively ultramicro grinding of manyspike tanoak leaf, radix scrophulariae, the Radix Astragali, the root of kudzu vine and sealwort, obtain medicinal powder;
B, by weight proportion described in any one of claims 1 to 3, the medicinal powder getting steps A carries out ultrasonic wave or microwave radiation exaraction, obtains extract;
C, the extract getting step B carry out filtering with microporous membrane, concentrated, obtain concentrate for preparation and get final product;
Described steps A is by medicine materical crude slice ultramicro grinding to 200 order or thinner.
7. the method for falling hypoglycemic Chinese medicine composition and preparing preparation according to claim 6, it is characterized in that: the preparation method of the prepared slices of Chinese crude drugs of described radix scrophulariae, the Radix Astragali, the root of kudzu vine and sealwort comprises the following steps: the fresh medicinal material getting radix scrophulariae, the Radix Astragali, the root of kudzu vine and sealwort, through cleaning, drying, stripping and slicing, after degreasing, dry obtained.
8. utilize and fall the method that hypoglycemic Chinese medicine composition prepares capsule described in any one of claim 1 to 3, comprise the following steps:
Get the prepared slices of Chinese crude drugs ultramicro grinding of manyspike tanoak leaf, radix scrophulariae, the Radix Astragali, the root of kudzu vine and sealwort by weight proportion described in any one of claims 1 to 3 respectively, cross 200 mesh sieves, obtain medicinal powder batch mixing, encapsulated, to obtain final product.
9. the method for falling hypoglycemic Chinese medicine composition and preparing capsule according to claim 8, it is characterized in that: the preparation method of the prepared slices of Chinese crude drugs of described radix scrophulariae, the Radix Astragali, the root of kudzu vine and sealwort comprises the following steps: the fresh medicinal material getting radix scrophulariae, the Radix Astragali, the root of kudzu vine and sealwort, through cleaning, drying, stripping and slicing, after degreasing, dry obtained.
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Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102144692A (en) * | 2010-09-25 | 2011-08-10 | 重庆辰龙制药有限公司 | Sweet tea and preparation method thereof |
CN102218085A (en) * | 2010-04-13 | 2011-10-19 | 常州善美药物研究开发中心有限公司 | Quality control method for leaves of lithocarpus litseifolius(Hance)Chun as medicinal material |
CN102526484A (en) * | 2012-02-16 | 2012-07-04 | 许从玉 | Medicinal composition for decreasing blood sugar |
-
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CN102144692A (en) * | 2010-09-25 | 2011-08-10 | 重庆辰龙制药有限公司 | Sweet tea and preparation method thereof |
CN102526484A (en) * | 2012-02-16 | 2012-07-04 | 许从玉 | Medicinal composition for decreasing blood sugar |
Non-Patent Citations (5)
Title |
---|
中药治疗糖尿病的心得体会;李春亮等;《张家口医学院学报》;20021231;第19卷(第03期);14-15 * |
浅谈影响中药提取质量的主要因素;鲁冰;《山东中医杂志》;20031031;第22卷(第10期);627-628 * |
糖尿病从脾论治浅析;张育清;《实用中医内科杂志》;20050430;第19卷(第02期);124 * |
糖尿病药对临床应用心得;李凤鸣;《中国社区医师(综合版)》;20071231;第9卷(第13期);147-148 * |
赵艳华.糖尿病的临床中药治疗体会.《中国保健(医学研究版)》.2007,第15卷(第14期),116-117. * |
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