CN107087789A - A kind of yellow hypoglycemic Ultramicro-powder pharmaceutical formulation of mulberry Pueraria lobota and its application - Google Patents
A kind of yellow hypoglycemic Ultramicro-powder pharmaceutical formulation of mulberry Pueraria lobota and its application Download PDFInfo
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- CN107087789A CN107087789A CN201710408250.2A CN201710408250A CN107087789A CN 107087789 A CN107087789 A CN 107087789A CN 201710408250 A CN201710408250 A CN 201710408250A CN 107087789 A CN107087789 A CN 107087789A
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- 235000008708 Morus alba Nutrition 0.000 title claims abstract description 71
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
- B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
- B02C19/00—Other disintegrating devices or methods
- B02C19/06—Jet mills
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Alternative & Traditional Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Food Science & Technology (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides a kind of yellow hypoglycemic Ultramicro-powder pharmaceutical formulation of mulberry Pueraria lobota, it is characterised in that：The active component of the compound is made up of mulberry leaf, the root of kudzu vine, sealwort；Antihypelipidemic foodstuff, health food or/and medicine that the present invention is prepared using ultra micro powder craft.The formula and ultra micro powder craft provided compared to more traditional extraction and purification process, the present invention is more simple in technique, can effectively control the quality of product.
Description
Technical field
The invention provides a kind of formula food being made up of medicine-food two-purpose medicinal material, the more specifically present invention provides one
Plant a kind of yellow hypoglycemic Ultramicro-powder pharmaceutical formulation of mulberry Pueraria lobota with hypoglycemic activity and its application.
Technical background
Traditional medicine thinks that " healthy tendency " is vigorous in vivo, can resist the invasion and attack of various " perverse trends " (pathogenic factor), tradition doctor
Learn the effect for emphasizing very much " healthy tendency ", it is believed that generation, development and the conversion of disease depend on the growth and decline that good and evil are struggled against, so as to propose
The base therapy thinking of " strengthening vital QI to eliminate pathogenic factors ", that is, emphasize, from entirety, to strengthen the immunity of body to resist with disease.Doctor trained in Western medicine
Think that immunity is a kind of ability that human immune system carries out self-protection, one of main effect be body resistance bacterium or
The ability of the infection such as virus.
Since ancient times, the traditional Chinese medical science just using mulberry leaf as treatment diabetes (i.e. the diabetes of modern medicine) application in TCM in facing
Bed, Japanese ancient book《Eat tea health note》Also recording mulberry leaf plays the role of improvement " drinking-water disease " (i.e. the diabetes of modern medicine).Mulberry
Leaf is as medicine-food two-purpose material, and studying data at home and abroad is confirmed, alkaloid and polysaccharide are main blood sugar reducing components in mulberry leaf,
It produces inhibitory action by decomposing enzymatic activity to disaccharides, so that suppress absorption of the small intestine to disaccharide, blood glucose after reduction food
Peak value.In mulberry leaf alkaloid and mulberry leaf polysaccharide promote β cells point must insulin, and insulin can promote cell to the profit of sugar
With the synthesis of, hepatic glycogen and improve glycometabolism, be finally reached hypoglycemic effect.The polyhydroxy isolated from mulberry leaf removes first Liang
Henbane alkali has very strong glycosidase inhibiting function；Blood sugar level can be significantly decreased, the generation of diabetes is greatly reduced.
The root of kudzu vine is medicine-food two-purpose, has inducing diaphoresis to bring down a fever, promotes the production of body fluid to quench thirst, the function of antidiarrheal, and can improve hypertensive diabetes disease
The symptoms such as Xiang Qiang, dizziness, the headache of people.Root of kudzu vine extraction flavonoid substances are combined to form with mulberry-leaf extract DNJ to be washed
The clear sugar of pancreas is plain (cics), can deeply enter small enteral and suppress human body invertase, maltose, alpha-glucosaccharase carbohydrase, alpha-amylase
Activity, combined, direct decomposition glucose, lightened the burden for impaired pancreas islet with alpha-glucosidase, enhancing islet receptor activity cleans pancreas
Island cell, removes unnecessary indissoluble sugared part, activates islet cells, it is recovered pancreas function, with bidirectional modulation blood glucose,
Recover itself function carbohydrate metabolism；There is quick repair to be damaged β cells, make pancreatic cell regeneration, nutrition pancreas strengthens body immunity
Effect.
Sealwort is liliaceous plant P. kingianum Polygonatum kingianum Coll.et Hemsl., sealwort
Polygonatum sibiricum Red. or David's-harp Polygonatum cyrtonema Hua dry rhizome.By shape
Shape is different, practises and claims " big sealwort ", " polygonatum sibiricum Redoute ", " RHIZOMA POLYGONATI ZINGIBERIFORME ".Spring, the excavation of season in autumn two, remove fibrous root, clean, put boiling water
It is middle slightly to scald or steam to the saturating heart, dry.Modern medicine study is found, a variety of chemical substances, such as organic acid, Yan are contained in sealwort
Acid, glutinous rehmannia glucoside and organic acid etc..Sealwort is soaked to be drunk with good health-care effect, is suffered from simultaneously for a variety of diseases
Good therapeutic action.Such as weakness of the spleen and the stomach, poor appetite, cough due to deficiency of the lung and situations such as asthenia of essence and blood, clothes that can be appropriate
Use sealwort；In the event of diabetes either diabetes, soaked drink of sealwort is either arranged in pairs or groups together with other Chinese medicines,
Also it can be good at promoting physical recovery health.
Ultramicro grinding refers to overcome solid interior cohesiveness to be allowed to broken using mechanical or hydrokinetic method, so that will
More than 3 millimeters of material particles are crushed to 10-25 microns of operating technology.It is modern high to adapt to after being 1970s
The development of new technology and a kind of materiel machining new and high technology produced.Ultramicro powder is the final products of ultramicro grinding, is had
The unexistent special physico-chemical property of general particle, such as good dissolubility, dispersiveness, adsorptivity, chemical reactivity.Therefore
Ultramicro powder is widely used to food, chemical industry, medicine, cosmetics agricultural chemicals, dyestuff, coating, electronics and Aero-Space etc. and permitted
On multi-field.Superfine communication technique is using methods such as supersonic jet mill, the crushing of cold slurry, with conventional purely mechanic crushing side
Method is entirely different.Hot-spot phenomenon will not be produced in crushing process, or even can be crushed under low-temperature condition, speed
It hurry up, moment can complete, thus retain the bioactive ingredients of powder to greatest extent, in favor of required high-quality volume production is made
Product.
Ultramicro grinding is effective crucial skill for solving plant cell wall breaking, improving that eating mouth feel and increase human consumption absorb
Art.The meaning of superfine communication technique is more prominent in terms of health food.As the improvement of people's living standards, people seek newly
Health nutraceutical be a main trend.Because China lacks advanced ultramicro grinding process technology, substantial amounts of agricultural byproducts
Intensive processing utilization is unable to, the waste of Edible resource is caused.Such as wheat bran, oat hull, maize peel, rice bran, bean dregs
Etc. feed is mainly used in, without good development and utilization.Domestic and international nutritionist expert already unanimously thinks wheat bran and rice bran
It is very high " health food " containing dietary fiber.It is that 17.6%, fat is 8.3% that its fiber content, which is up to 43.9%, protein,.
Eat these food and be beneficial to human metabolism, and to preventing constipation, reduction cholesterol, prevention of arterial hardening etc. have bright
Effective fruit.Application of the Crushing of Ultrafine technology in food processing has the significance of two aspects, and one is the mouthfeel for improving food,
And be conducive to the absorption of nutriment；Two be that the raw material that can not be fully absorbed or utilize originally is re-used, and prepares and adds deeply
Work develops new food material, adds new food kind, improve resource utilization into various functions food.China's food work
Proportion of the industry gross output value in industrial department has been leapt to the first position, reaches 5,00,000,000,000 yuan of scale, but product structure is closed not to the utmost
Reason, deep processed product instant food manufacturing industry only accounts for 16%.At present, promote the deep processing of food industry, improve added value of product
Common recognition as society and enterprise.Therefore, superfine communication technique will have wide as a kind of new and high technology in food processing
Application prospect.
The content of the invention
In order to which the present invention that solves the above problems provides a kind of mulberry Pueraria lobota yellow hypoglycemic Ultramicro-powder pharmaceutical formulation, the activity of the compound
Composition is made up of mulberry leaf, the root of kudzu vine, sealwort.
The mulberry leaf root of kudzu vine sealwort capsule is made up of the Ultramicro-powder of mulberry leaf, the root of kudzu vine, sealwort.
The mulberry leaf, the root of kudzu vine, the ultra micro Powder Particle Size of sealwort are in the mesh of 500 mesh -2000.
The mulberry leaf, the root of kudzu vine, the ultra micro Powder Particle Size of sealwort are 700 mesh.
A kind of yellow hypoglycemic Ultramicro-powder pharmaceutical formulation of described mulberry Pueraria lobota, it is characterised in that：The mulberry leaf, the root of kudzu vine, the group of sealwort
Compare 1-2 into weight:2-6:2-6.
A kind of yellow hypoglycemic Ultramicro-powder pharmaceutical formulation of described mulberry Pueraria lobota, it is characterised in that：The mulberry leaf, the root of kudzu vine, the group of sealwort
It is 1 into weight ratio:2:2.
The preparation method of mulberry Pueraria lobota Huang hypoglycemic Ultramicro-powder pharmaceutical formulation, comprises the following steps：
1) mulberry leaf, the root of kudzu vine, sealwort after cleaning will be screened, moisture in mulberry leaf, the root of kudzu vine, sealwort is made using vacuum drying method
Content is 2%~10%；
2) being weighed respectively according to formula makes the mesh of granularity >=500 after medicinal material, crushing；
3) powder of mulberry leaf, the root of kudzu vine and sealwort is mixed, uses 50% alcohol granulation, dried；Obtain the yellow hypoglycemic ultra micro of mulberry Pueraria lobota
Powder particles.
The yellow hypoglycemic ultrafine powder particle of mulberry Pueraria lobota is filled into capsule with hard shell capsules, using 60C0-y irradiation sterilizations, irradiation dose is 4~
6kGy, obtains the yellow hypoglycemic ultra micro powder capsule of mulberry Pueraria lobota.
By the yellow hypoglycemic ultrafine powder particle tabletting of mulberry Pueraria lobota, using 60C0-y irradiation sterilizations, irradiation dose is 4~6kGy, is obtained
Mulberry Pueraria lobota Huang hypoglycemic ultra micro powder chewable tablet.
The method have the benefit that：The invention provides one kind, the antihypelipidemic foodstuff prepared using ultra micro powder craft,
Health food or/and medicine.The formula and ultra micro powder craft provided compared to more traditional extraction and purification process, the present invention is in technique
On it is more simple, can effectively control the quality of product.
Embodiment
The preparation of the mulberry Pueraria lobota of embodiment 1 Huang hypoglycemic Ultramicro-powder formula
1st, mulberry leaf, the root of kudzu vine, the crushing of sealwort and granularity
Mulberry leaf (S), the root of kudzu vine (G) and sealwort (H) are weighed respectively, and using forced air drying, No. 9 were crushed using traditional powder beater
Sieve, numbering S1, G1, H1.
Mulberry leaf (S), the root of kudzu vine (G) and sealwort (H) separately are weighed, is freeze-dried, ultramicro grinding, particle size analyzer determination grain is carried out
Degree, numbering S2, G2, H2, S3, G3, H3, S4, G4, H4, S5, G5, H5, S6, G6, H6, S7, G7, H7, specific such as the institute of table 1 respectively
Show.
The grinding particle size table of table 1
According to comminution of material self character, material is crushed in different ways, mulberry leaf, the root of kudzu vine and sealwort crushing is obtained
Grain and Ultramicro-powder, and measure respective component different grain size.
2nd, the activity investigation of different grinding particle sizes pair
By mulberry leaf, the root of kudzu vine and the mesh ultramicro grinding powder of sealwort 200 according to S1, G1 and H1 weight ratio 1:2:2 mixing, using medicine
The water refluxing extraction of 5 times of material weight 3 times, each 30min, centrifugal filtration obtains extract solution, merges extract solution and is concentrated into 1g lifes
Medicine/mL.As a control group.
(know the research of what small intestinal mucosa disaccharidase using classical alpha-glucosaccharase enzyme inhibition activity in vitro models
The contemporary livestock and poultry breeding industries of [J] that is in progress, 2007,06:20-22；Schmidt DD,Frommer W,Junge B,et al.α-
Glucosidase inhibitors[J].Sci Nat,1977,64(10):535-536) investigate the drop of above-mentioned Ultramicro-powder formula
Sugar effect.
In vitro using Tang Mingmin (the quick mulberry leaf blood sugar reductions active principle bases of Tang Ming and its mechanism of action in the preparation of model
Study [D] Beijing University of Chinese Medicine, 2016) the external alpha-glucosidase reaction system set up sets up.
The ultramicro grinding powder that above-mentioned experimental group 1,2,3,4,5 is prepared is each configured to 0.11gL-1、
0.52g·L-1、 1.02g·L-1、5.1g·L-1、10.2g·L-1The mixed rotary liquid of water carries out alpha-glucosaccharase enzyme inhibition rate measure.
50 μ L intestines extract solutions are taken to add 67mmolL-1Phosphoric acid buffer salt buffer (pH6.8), 37 DEG C of water-bath temperature incubate 10min, are separately added into
100 μ LpNPG (10mmolL are being added after the above-mentioned saturation 5min of experimental group 1,2,3,4,5-1), system cumulative volume is 350 μ L,
After water-bath 30min, 0.1molL is added-1Na2CO3400 μ L terminating reactions.Sample solution be placed in 96 orifice plates with ELIASA in
Absorbance is determined at 405nm.Control group (correspondence crude drug concentration is measured), negative control (without inhibitor, supplement buffering
Liquid) and blank control (being not added with substrate and inhibitor, supplement buffer solution) calculating inhibiting rate, and draw the suppression of various concentrations extract part
Rate curve processed, calculates IC50。
Inhibiting rate (%)=[(A feminine gender-A samples)/(A feminine gender-A blank)] × 100%
By mulberry leaf, the root of kudzu vine and the mesh ultramicro grinding powder of sealwort 200 according to S1, G1 and H1 weight ratio 1:2:2 are mixed with
To experimental group A.By mulberry leaf, the root of kudzu vine and the mesh ultramicro grinding powder of sealwort 400 according to S2, G2 and H2 weight ratio 1:2:2 are mixed with
Obtain experimental group B；By mulberry leaf, the root of kudzu vine and the mesh ultramicro grinding powder of sealwort 500 according to S3, G3 and H3 weight ratio 1:2:2 mixing systems
It is standby to obtain experimental group C；By mulberry leaf, the root of kudzu vine and the mesh ultramicro grinding powder of sealwort 600 according to S4, G4 and H4 weight ratio 1:2:2 mixing
Experimental group D is prepared, by mulberry leaf, the root of kudzu vine and the mesh ultramicro grinding powder of sealwort 700 according to S5, G5 and H5 weight ratio 1:2:2 mix
Conjunction prepares experimental group E, by mulberry leaf, the root of kudzu vine and the mesh ultramicro grinding powder of sealwort 800 according to S6, G6 and H6 weight ratio 1:2:2
It is mixed with and obtains experimental group F.Investigated not using above-mentioned identical alpha-glucosaccharase enzyme inhibition activity in vitro models
The blood sugar reducing function of the Ultramicro-powder of one-size.
Experimental group to gradient concentration carries out the inhibiting rate measure of alpha-glucosidase, draws inhibiting rate curve and simultaneously calculates
IC50, the result of each sample is as shown in table 2.Compare each extract part IC50As a result show, alpha-glucosaccharase enzyme inhibition activity intensity
Order is experimental group E>Experimental group F>Experimental group D>Experimental group C>Control group>Experimental group B>Experimental group A, it was found from experimental data,
It can judge to diminish with granularity substantially, the activity of each experimental group shows a rising trend, after particle diameter is less than 600 mesh, activity
It is stable, illustrate Task-size Controlling 600 mesh and more than, it is possible to realize the breaking-wall cell of medicinal material, turn of effective guarantee active component
Move.
The alpha-glucosidase 503nhibiting concentration of the varigrained Ultramicro-powder of table 2
| Group | IC50(g·L-1) |
| Experimental group A (200 mesh) | 5.14 |
| Experimental group B (400 mesh) | 1.25 |
| Experimental group C (500 mesh) | 0.97 |
| Experimental group D (600 mesh) | 0.58 |
| Experimental group E (700 mesh) | 0.43 |
| Experimental group F (800 mesh) | 0.44 |
| Control group | 1.02 |
3rd, different formulations are formulated the influence of activity to the yellow hypoglycemic Ultramicro-powder of mulberry Pueraria lobota
By mulberry leaf, the root of kudzu vine and the mesh ultramicro grinding powder of sealwort 2000 according to S7, G7 and H7 weight ratio 1:1:1 is mixed with
To experimental group 1.By S7, G7 and H7 weight ratio 1:2:2 are mixed with and obtain experimental group 2；By S7, G7 and H7 weight ratio 1:3:3 mix
Conjunction prepares experimental group 3；By S7, G7 and H7 weight ratio 1:6:6 are mixed with and obtain experimental group 4, regard mulberry leaf S7 as experiment
Group 5.
The inhibiting rate for carrying out alpha-glucosidase using the above-mentioned experimental group to gradient concentration is determined.Set up the positive simultaneously
Compare (acarbose, Chinese medicines quasi-word H20103164, Haizheng Medicine Stock Co., Ltd., Zhejiang Prov), configure acarbose
0.051g·L-1、 0.25g·L-1、0.51g·L-1、0.75g·L-1、1.05g·L-1Carry out alpha-glucosaccharase enzyme inhibition rate survey
It is fixed.
The inhibiting rate of the alpha-glucosidase of the experimental group of gradient concentration is determined, inhibiting rate curve is drawn and calculates IC50,
The result of each sample is as shown in table 3.Compare each extract part IC50As a result show, alpha-glucosaccharase enzyme inhibition activity intensity sequence
For experimental group 2>Experimental group 1>Experimental group 3>Experimental group 4>Experimental group 5>Active most strong, the explanation of acarbose, wherein experimental group 1
Mulberry leaf, the root of kudzu vine and sealwort weight compare 1:2:2 be preferable Ultramicro-powder formula.
The alpha-glucosidase 503nhibiting concentration of the mesh Ultramicro-powder of 3 each group of table 2000 formula
| Group | IC50(g·L-1) |
| Experimental group 1 (1:1:1) | 0.74 |
| Experimental group 2 (1:2:2) | 0.43 |
| Experimental group 3 (1:3:3) | 0.70 |
| Experimental group 4 (1:6:6) | 1.05 |
| Experimental group 5 | 2.30 |
| Positive controls (acarbose) | 0.12 |
Claims (10)
1. a kind of yellow hypoglycemic Ultramicro-powder pharmaceutical formulation of mulberry Pueraria lobota, it is characterised in that：The active component of the compound by mulberry leaf, the root of kudzu vine,
Sealwort is constituted.
2. the yellow hypoglycemic Ultramicro-powder pharmaceutical formulation of a kind of mulberry Pueraria lobota according to claim 1, it is characterised in that：The mulberry leaf root of kudzu vine
Sealwort capsule is made up of the Ultramicro-powder of mulberry leaf, the root of kudzu vine, sealwort.
3. the yellow hypoglycemic Ultramicro-powder pharmaceutical formulation of a kind of mulberry Pueraria lobota according to claim 3, it is characterised in that：The mulberry leaf, Pueraria lobota
Root, the ultra micro Powder Particle Size of sealwort are in the mesh of 500 mesh -2000.
4. the yellow hypoglycemic Ultramicro-powder formula of a kind of mulberry Pueraria lobota according to claim 4, it is characterised in that：The mulberry leaf, the root of kudzu vine, Huang
The ultra micro Powder Particle Size of essence is 700 mesh.
5. according to a kind of yellow hypoglycemic Ultramicro-powder pharmaceutical formulation of any described mulberry Pueraria lobota of claim 3 or 4, it is characterised in that：It is described
Mulberry leaf, the root of kudzu vine, the composition weight of sealwort compare 1-2:2-6:2-6.
6. the yellow hypoglycemic Ultramicro-powder pharmaceutical formulation of a kind of mulberry Pueraria lobota according to claim 5, it is characterised in that：The mulberry leaf, Pueraria lobota
Root, the composition weight ratio of sealwort are 1:2:2.
7. a kind of preparation method of the yellow hypoglycemic Ultramicro-powder pharmaceutical formulation of mulberry Pueraria lobota, it is characterised in that：Comprise the following steps：
1) mulberry leaf, the root of kudzu vine, sealwort after cleaning will be screened, moisture in mulberry leaf, the root of kudzu vine, sealwort is made using vacuum drying method
For 2%~10%；
2) being weighed respectively according to formula makes the mesh of granularity >=500 after medicinal material, crushing；
3) powder of mulberry leaf, the root of kudzu vine and sealwort is mixed, uses 50% alcohol granulation, dried, whole grain, obtain the yellow hypoglycemic ultra micro of mulberry Pueraria lobota
Powder particles.
8. the preparation method of the yellow hypoglycemic Ultramicro-powder pharmaceutical formulation of mulberry Pueraria lobota according to claim 7, it is characterised in that：By mulberry Pueraria lobota
Yellow hypoglycemic ultrafine powder particle fills capsule with hard shell capsules, using 60C0-y irradiation sterilizations, and irradiation dose is 4~6kGy, obtains Sang Gehuang
Hypoglycemic ultra micro powder capsule.
9. the preparation method of the yellow hypoglycemic Ultramicro-powder pharmaceutical formulation of mulberry Pueraria lobota according to claim 8, it is characterised in that：By mulberry Pueraria lobota
Yellow hypoglycemic ultrafine powder particle tabletting, using 60C0-y irradiation sterilizations, irradiation dose is 4~6kGy, obtains the yellow hypoglycemic ultra micro of mulberry Pueraria lobota
Powder chewable tablet.
10. the yellow hypoglycemic Ultramicro-powder pharmaceutical formulation of mulberry Pueraria lobota the answering in antihypelipidemic product is prepared described in any one of claim 5 or 6
With.
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| CN108741032A (en) * | 2018-06-06 | 2018-11-06 | 成都中医药大学附属医院 | A kind of health food or pharmaceutical composition and preparation method thereof with hypoglycemic effect |
| CN109123296A (en) * | 2018-08-01 | 2019-01-04 | 刘英奎 | Pueraria lobata mulberry leaf compound solid beverage and preparation method |
| CN112691166A (en) * | 2019-10-23 | 2021-04-23 | 赵政 | Medicine containing Chinese medicine components and its prepn |
| CN113693146A (en) * | 2021-07-20 | 2021-11-26 | 红河学院 | Mulberry leaf and rhizoma polygonati tea and preparation method thereof |
| CN114431384A (en) * | 2022-01-27 | 2022-05-06 | 四川省川北人家农业科技有限公司 | Mulberry leaf and sealwort instant beverage and preparation method thereof |
| CN114732869A (en) * | 2021-01-07 | 2022-07-12 | 吴月英 | Chinese medicinal composition for treating diabetes and preparation method thereof |
| CN116211968A (en) * | 2023-03-09 | 2023-06-06 | 青岛康迈臣生物科技有限责任公司 | Hypoglycemic composition, preparation method and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108741032A (en) * | 2018-06-06 | 2018-11-06 | 成都中医药大学附属医院 | A kind of health food or pharmaceutical composition and preparation method thereof with hypoglycemic effect |
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| CN112691166A (en) * | 2019-10-23 | 2021-04-23 | 赵政 | Medicine containing Chinese medicine components and its prepn |
| CN114732869A (en) * | 2021-01-07 | 2022-07-12 | 吴月英 | Chinese medicinal composition for treating diabetes and preparation method thereof |
| CN113693146A (en) * | 2021-07-20 | 2021-11-26 | 红河学院 | Mulberry leaf and rhizoma polygonati tea and preparation method thereof |
| CN114431384A (en) * | 2022-01-27 | 2022-05-06 | 四川省川北人家农业科技有限公司 | Mulberry leaf and sealwort instant beverage and preparation method thereof |
| CN116211968A (en) * | 2023-03-09 | 2023-06-06 | 青岛康迈臣生物科技有限责任公司 | Hypoglycemic composition, preparation method and application thereof |
| CN116211968B (en) * | 2023-03-09 | 2024-08-20 | 青岛康迈臣生物科技有限责任公司 | Hypoglycemic composition, preparation method and application thereof |
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