CN114732869A - Chinese medicinal composition for treating diabetes and preparation method thereof - Google Patents
Chinese medicinal composition for treating diabetes and preparation method thereof Download PDFInfo
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- 206010012601 diabetes mellitus Diseases 0.000 title claims abstract description 38
- 239000000203 mixture Substances 0.000 title claims abstract description 36
- 238000002360 preparation method Methods 0.000 title abstract description 7
- 239000003814 drug Substances 0.000 claims abstract description 44
- 239000002994 raw material Substances 0.000 claims abstract description 22
- 239000000843 powder Substances 0.000 claims description 17
- 241000301400 Trogopterus Species 0.000 claims description 11
- 210000003608 fece Anatomy 0.000 claims description 11
- 229940079593 drug Drugs 0.000 claims description 9
- 240000001462 Pleurotus ostreatus Species 0.000 claims description 8
- 235000001603 Pleurotus ostreatus Nutrition 0.000 claims description 8
- 239000006187 pill Substances 0.000 claims description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- 238000010298 pulverizing process Methods 0.000 claims description 6
- 235000007685 Pleurotus columbinus Nutrition 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 239000011248 coating agent Substances 0.000 claims description 3
- 238000000576 coating method Methods 0.000 claims description 3
- 238000001914 filtration Methods 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- 239000007779 soft material Substances 0.000 claims description 3
- 241000222350 Pleurotus Species 0.000 claims description 2
- 239000002245 particle Substances 0.000 claims description 2
- 238000007873 sieving Methods 0.000 claims description 2
- 239000008280 blood Substances 0.000 abstract description 26
- 210000004369 blood Anatomy 0.000 abstract description 26
- 240000000249 Morus alba Species 0.000 abstract description 11
- 235000008708 Morus alba Nutrition 0.000 abstract description 11
- 244000046146 Pueraria lobata Species 0.000 abstract description 10
- 235000010575 Pueraria lobata Nutrition 0.000 abstract description 10
- 241000218989 Trichosanthes Species 0.000 abstract description 9
- 235000017784 Mespilus germanica Nutrition 0.000 abstract description 8
- 244000182216 Mimusops elengi Species 0.000 abstract description 8
- 235000000560 Mimusops elengi Nutrition 0.000 abstract description 8
- 235000007837 Vangueria infausta Nutrition 0.000 abstract description 8
- 241000972672 Phellodendron Species 0.000 abstract description 3
- 208000024891 symptom Diseases 0.000 description 10
- 241000972673 Phellodendron amurense Species 0.000 description 8
- 230000000694 effects Effects 0.000 description 7
- 208000008454 Hyperhidrosis Diseases 0.000 description 4
- 206010033557 Palpitations Diseases 0.000 description 4
- 230000007774 longterm Effects 0.000 description 4
- 230000035900 sweating Effects 0.000 description 4
- 230000035922 thirst Effects 0.000 description 4
- 208000002193 Pain Diseases 0.000 description 3
- 241000756042 Polygonatum Species 0.000 description 3
- 230000001684 chronic effect Effects 0.000 description 3
- 206010013781 dry mouth Diseases 0.000 description 3
- 230000002218 hypoglycaemic effect Effects 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 244000241872 Lycium chinense Species 0.000 description 2
- 235000015468 Lycium chinense Nutrition 0.000 description 2
- 235000008737 Polygonatum biflorum Nutrition 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- 206010006895 Cachexia Diseases 0.000 description 1
- 206010020710 Hyperphagia Diseases 0.000 description 1
- 206010023379 Ketoacidosis Diseases 0.000 description 1
- 208000007976 Ketosis Diseases 0.000 description 1
- 241001106041 Lycium Species 0.000 description 1
- 244000252132 Pleurotus eryngii Species 0.000 description 1
- 235000001681 Pleurotus eryngii Nutrition 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 241000219780 Pueraria Species 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 208000016097 disease of metabolism Diseases 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 208000026500 emaciation Diseases 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 201000001421 hyperglycemia Diseases 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 208000030159 metabolic disease Diseases 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 206010062198 microangiopathy Diseases 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 231100000862 numbness Toxicity 0.000 description 1
- 208000033808 peripheral neuropathy Diseases 0.000 description 1
- 206010036067 polydipsia Diseases 0.000 description 1
- 208000022530 polyphagia Diseases 0.000 description 1
- 210000001525 retina Anatomy 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/24—Mucus; Mucous glands; Bursa; Synovial fluid; Arthral fluid; Excreta; Spinal fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
- A61K36/428—Trichosanthes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- Diabetes (AREA)
- Biomedical Technology (AREA)
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Abstract
The invention discloses a traditional Chinese medicine composition for treating diabetes, which comprises the raw material medicine components of phellodendron, rhizoma polygonati, medlar, mulberry leaf, trichosanthes root, kudzu root and the like, and has the advantages of simple compatibility, easy preparation, convenient taking and better blood sugar control for diabetic patients.
Description
Technical Field
The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for treating diabetes, a preparation method and application thereof.
Background
Diabetes is a chronic systemic metabolic disease, which is mainly characterized by chronic hyperglycemia and diabetes, has no symptoms in the early clinical presentation, can have symptoms of polydipsia, polyphagia, diuresis, emaciation and the like when developing to the clinical symptom stage, can have ketoacidosis when being serious, and has common complications of acute infection, atherosclerosis, microangiopathy such as kidney and retina and peripheral neuropathy.
Diabetes cannot be cured at present, and the treatment targets of the diabetes are mainly blood sugar control, acute metabolic complications prevention, chronic complications prevention and the like. From the effect of the existing clinical medicines, the curative effect of the chemical hypoglycemic medicine for treating diabetes is determined, but the chemical hypoglycemic medicine needs to be added gradually after long-term use, and the long-term use of the chemical hypoglycemic medicine has certain adverse reaction and even serious side effect, and can not effectively control complications. The treatment of diabetes by traditional Chinese medicine is an empirical prescription since ancient times. However, the treatment effect will be different depending on the Chinese medicinal composition. It is hoped that the traditional Chinese medicine composition with simple compatibility, simple and convenient preparation and definite curative effect can be obtained.
Disclosure of Invention
In order to overcome the above problems, the present inventors have conducted intensive studies and found that a Chinese medicinal composition obtained by selecting phellodendron, polygonatum, lycium, mulberry leaf, trichosanthes root and pueraria root has a good therapeutic effect on the treatment of diabetes, thereby completing the present invention.
The object of the present invention is to provide the following:
1. a Chinese medicinal composition for treating diabetes comprises cortex Phellodendri, rhizoma Polygonati, fructus Lycii, folium Mori, Trichosanthis radix, radix Puerariae, etc.
2. The traditional Chinese medicine composition for treating diabetes mellitus as described in the above 1 comprises the following raw materials by weight:
40-80 parts of phellodendron bark
30-50 parts of rhizoma polygonati
50-70 parts of medlar
30-50 parts of mulberry leaves
30-50 parts of trichosanthes root
30-50 parts of kudzu root.
3. The traditional Chinese medicine composition for treating diabetes as described in the above 1, comprises the following raw material medicines by weight:
60 parts of phellodendron bark
40 parts of rhizoma polygonati
60 parts of medlar
40 parts of mulberry leaves
40 parts of trichosanthes root
40 parts of kudzu root.
4. The traditional Chinese medicine composition for treating diabetes as described in the above 1, further comprising at least one of pleurotus ostreatus and trogopterus dung.
5. The traditional Chinese medicine composition for treating diabetes as described in the above 4, further comprising oyster mushroom and trogopterus dung.
6. The traditional Chinese medicine composition for treating diabetes as described in the above 4, the weight ratio of pleurotus eryngii and/or trogopterus dung is respectively as follows:
30-50 parts of oyster mushroom
30-50 parts of trogopterus dung.
7. The traditional Chinese medicine composition for treating diabetes as described in the above 5, comprises the following raw material medicines by weight:
60 parts of phellodendron bark
40 parts of rhizoma polygonati
60 parts of medlar
40 parts of mulberry leaves
40 parts of trichosanthes root
40 parts of kudzu root
40 parts by weight of side ear
40 parts of trogopterus dung.
8. The traditional Chinese medicine composition for treating diabetes mellitus of any one of 1 to 7, which is powder, pill or decoction.
9. The preparation method of the traditional Chinese medicine composition for treating diabetes mellitus of any one of the 1 to 7 comprises the following steps:
pulverizing the raw materials, and mixing to obtain powder; or
Pulverizing the raw materials, sieving, adding water, making soft material, making pill, and coating to obtain pill; or
Decocting part of the raw materials with water for 30-60 min, filtering to obtain decoction, pulverizing the other part of the raw materials into fine powder, and mixing the fine powder with the decoction to obtain decoction.
10. The preparation method of the traditional Chinese medicine composition for treating diabetes described in the above 9, wherein, when preparing decoction, the other part of the raw material medicines are crushed into fine powder with a particle size of below 400 meshes.
The traditional Chinese medicine composition for treating diabetes provided by the invention is simple in compatibility, easy to prepare, convenient to take and better in controlling blood sugar of a diabetic patient.
Detailed Description
The present invention will be described in further detail below with reference to preferred embodiments. The features and advantages of the present invention will become more apparent from the description.
The invention selects phellodendron, rhizoma polygonati, medlar, mulberry leaf, trichosanthes root and kudzu root as raw material medicines of a basic prescription through reasonable compatibility, and is preferably matched with pleurotus and/or trogopterus dung, the obtained traditional Chinese medicine composition can better reduce and stabilize the blood sugar level of a diabetic patient after long-term continuous taking for 3 months, and the blood sugar level of the diabetic patient is basically kept at a healthy low level after long-term continuous taking for 1 year.
In the invention, the selected raw material medicine has strict requirements, and the obtained traditional Chinese medicine composition has a good blood sugar control effect when the raw material medicine is prepared according to the following weight ratio:
40-80 parts of phellodendron bark
30-50 parts of rhizoma polygonati
50-70 parts of medlar
30-50 parts of mulberry leaves
30-50 parts of trichosanthes root
30-50 parts by weight of kudzu-vine root,
optionally, 30-50 parts by weight of oyster mushroom
Optionally, 30-50 parts by weight of trogopterus dung.
Particularly, the preferred dosage ratio of the traditional Chinese medicine composition is as follows:
60 parts of phellodendron bark
40 parts of rhizoma polygonati
60 parts of medlar
40 parts of mulberry leaves
40 parts of trichosanthes root
40 parts of kudzu root.
Furthermore, the preferable dosage ratio of the traditional Chinese medicine composition is as follows:
60 parts of phellodendron bark
40 parts of sealwort
60 parts of medlar
40 parts of mulberry leaves
40 parts of trichosanthes root
40 parts of kudzu root
40 parts by weight of side ear
40 parts of trogopterus dung.
The traditional Chinese medicine composition provided by the invention can be prepared by a common method in the field, such as crushing to prepare powder, crushing, adding water to prepare soft materials, then preparing pills and coating to obtain pills, or decocting with water to prepare decoction. Preferably, however, part of the raw materials are decocted with water for 30-60 minutes, filtered to obtain decoction, the other part of the raw materials are pulverized into fine powder, and the fine powder is mixed with the decoction to obtain decoction, which has better effect of controlling blood sugar of patients.
Example 1
The medicine with the following mixture ratio is crushed to 400 meshes and mixed to obtain powder:
phellodendron bark, cortex Phellodendri 60g
40g of Siberian solomonseal rhizome
Chinese wolfberry fruit 60g
Mulberry leaf 40g
Trichosanthis radix 40g
40g of kudzu root.
Example 2
The medicine with the following mixture ratio is crushed into fine powder and sieved by a 400-mesh sieve:
phellodendron bark, cortex Phellodendri 60g
40g of Siberian solomonseal rhizome
Chinese wolfberry fruit, fructus Lycii 60g
Mulberry leaf 40g
Trichosanthis radix 40g
Root of kudzu vine 40g
Side ear 40g
Oletum Trogopterori 40g
Decocting cortex Phellodendri, rhizoma Polygonati, fructus Lycii, radix Puerariae and Pleurotus Ostreatus with 550ml water for 30 min, filtering, collecting filtrate to obtain decoction, and adding folium Mori, Trichosanthis radix and Oletum Trogopterori fine powder to obtain decoction.
Experimental example 1
From 2014 to 2018, 30 diabetes (diabetes) patients are treated totally, the powder or decoction of the example 1 is taken 3 doses each day, after 3 months of taking, the blood sugar is controlled to be between 13.9 and 15.6mmol/L, after 6 months, the blood sugar is controlled to be between 8.9 and 10.8 mmol/L, after 9 months, the blood sugar is controlled to be between 7.8 and 8.5mmol/L, and after 12 months, the blood sugar is controlled to be between 4.6 and 6.7.
Typical case 1
A patient has a certain Liu, and the patient is diagnosed 7 months and 18 days in 2015, and has lumbocrural pain, palpitation, sweating, thirst and 19.7mmol/L blood sugar. After taking the medicine for three months, the symptoms of lumbocrural pain, palpitation and sweating, dry mouth and thirst are relieved, the blood sugar is 15.2 mmol/L, the symptoms are basically relieved after six months, the blood sugar is 10.0mmol/L, the blood sugar is 6.9-7.5mmol/L after nine months, and the blood sugar is 5.9-6.6mmol/L after one year.
Typical case 2
A patient has a certain Liu, and is diagnosed in 2018, 2, 17 days, and the patients have numbness of hands and feet, weakness of waist and legs, palpitation and sweating, dry mouth and thirst, red tongue with fur, cracks in the middle of the tongue and 21.8 mmol/L blood sugar. After taking the decoction of the example 2 for three months, the symptoms are improved, the blood sugar is 14.8-15.3mmol/L, the symptoms are basically relieved after six months, the blood sugar is 8.9-10.0 mmol/L, the blood sugar is 7.8-8.2mmol/L after nine months, and the blood sugar is 5.6-6.1mmol/L after one year.
Typical case 3
A patient Wu is diagnosed in 2017, 9 and 26 days, and has symptoms of weakness in waist and lower extremities, general pain, palpitation, sweating, dry mouth, thirst, red tongue with fur, cracks in the middle of the tongue and 23.8 mmol/L of blood sugar. After taking the decoction of the example 2 for three months, the symptoms are improved, the blood sugar is 13.9-14.6mmol/L, the symptoms are basically relieved after six months, the blood sugar is 8.9-10.8 mmol/L, the blood sugar is 7.2-8.1mmol/L after nine months, and the blood sugar is 4.6-5.9mmol/L after one year.
The invention has been described in detail with reference to the preferred embodiments and illustrative examples. It should be noted, however, that these specific embodiments are only illustrative of the present invention and do not limit the scope of the present invention in any way. Various modifications, equivalent substitutions and alterations can be made to the technical content and embodiments of the present invention without departing from the spirit and scope of the present invention, and these are within the scope of the present invention. The scope of the invention is defined by the appended claims.
Claims (10)
1. A Chinese medicinal composition for treating diabetes comprises cortex Phellodendri, rhizoma Polygonati, fructus Lycii, folium Mori, Trichosanthis radix, radix Puerariae, etc.
2. The traditional Chinese medicine composition for treating diabetes as claimed in claim 1, which comprises the following raw material medicines in parts by weight:
3. the traditional Chinese medicine composition for treating diabetes as claimed in claim 1, which comprises the following raw material medicines in parts by weight:
4. the traditional Chinese medicine composition for treating diabetes as claimed in claim 1, further comprising at least one of pleurotus ostreatus and trogopterus dung.
5. The Chinese medicinal composition for treating diabetes as claimed in claim 4, further comprising Pleurotus ostreatus and Oletum Trogopterori.
6. The traditional Chinese medicine composition for treating diabetes as claimed in claim 4, wherein the weight ratio of the pleurotus and/or the trogopterus dung is respectively as follows:
30-50 parts of oyster mushroom
30-50 parts of trogopterus dung.
7. The traditional Chinese medicine composition for treating diabetes as claimed in claim 5, which comprises the following raw material medicines in parts by weight:
8. the traditional Chinese medicine composition for treating diabetes mellitus as claimed in any one of claims 1 to 7, which is powder, pill or decoction.
9. The method for preparing a Chinese medicinal composition for treating diabetes mellitus as claimed in any one of claims 1 to 7, comprising:
pulverizing the raw materials, and mixing to obtain powder; or
Pulverizing the raw materials, sieving, adding water, making soft material, making pill, and coating to obtain pill; or
Decocting part of the raw materials with water for 30-60 min, filtering to obtain decoction, pulverizing the other part of the raw materials into fine powder, and mixing the fine powder with the decoction to obtain decoction.
10. The method for preparing a Chinese medicinal composition for treating diabetes as claimed in claim 9, wherein, in preparing the decoction, the other part of the raw material medicines are pulverized into fine powder with a particle size of below 400 meshes.
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