CN105168140A - Preparation method and an application of non-decocting preparation of fresh traditional Chinese herbal medicine - Google Patents
Preparation method and an application of non-decocting preparation of fresh traditional Chinese herbal medicine Download PDFInfo
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Abstract
The invention provides a preparation method and an application of a non-decocting preparation of a fresh traditional Chinese herbal medicine and belongs to the technical field of traditional Chinese medicine preparation. According to the preparation method of the non-decocting preparation of the fresh Traditional Chinese herbal medicine, firstly, a special high-speed breaking and centrifuging device is adopted to break the traditional Chinese herbal medicine material at a high speed, a flow-state crude medicine is obtained and subjected to ultrasonic-wave processing, dissolution of effective ingredients is further enhanced, then the processed crude medicine is filtered, a filtrate is concentrated, dried, ground, sterilized and packaged, and a finished product is obtained. The preparation method is simple to control, green and environment-friendly, the processing steps have synergistic interaction, so that the preparation method has higher universality, the extraction efficiency is high, active ingredients are protected effectively, and the availability of the finished product of the traditional Chinese herbal medicine material is improved better.
Description
Technical field
The invention belongs to Chinese drug preparation technique field, be specifically related to preparation method and the application thereof of fresh plant free decoction preparation.
Background technology
Chinese medicine is Chinese nation's crystallization of wisdom, for ensureing that people ' s health has made tremendous contribution.The traditional dosage form of Chinese medicine has pill, powder, unguentum, medicated wine etc., but the deficiencies such as conventional dosage forms majority exists, and taking dose is large, dosage form thick, appearance poor, along with the raising of social development and people's economic level, these deficiencies have seriously constrained the paces of Chinese medicine development, introduce high-tech, utilizing new technique to improve the quality of Chinese medicine, is one of important channel of innovation of Chinese medicinal dosage form.
Fresh plant Chinese medicine, mainly refers to the natural juice of fresh plant class Chinese herbal medicine.It is one of the characteristic of the traditional Chinese medical science that fresh medicine is cured the disease, and its clinical practice is through the whole process of Chinese medicine and pharmacy flora development.The BAICAO that so-called " shennong went into the mountains collecting, tasting and testing different kinds of herbs to be used as medicine, one day and meet 70 poison " is tasted must be fresh grass undoubtedly.What " Bencao Congxin " was also loaded with " the fresh person of raw pick, smashes juice and drink it " says.Fresh goods Chinese medicine can be described as one of weapon that hominid fights back the disease, and ancient times, people constantly explored in productive labor, then through China's ancient Chinese medicine doctor clinical practice and summary, have accumulated rich experiences.The treatment that fresh medicine is sick to some febrile diseases, blood disorder, wound disease and difficult serious symptom etc., truly have effect that it is special, not only because fresh property of medicine nature flavour " pure ", fresh, the natural characteristic that juice alcohol, abnormal smells from the patient are all pure of medicine can be kept, also increase because it has directly to promote the production of body fluid the effect that liquid helps the moon.In southern areas such as China Guangdong, among the people for exterior syndrome, how to adopt a little Herba Verbenae, (mud) Herba Kalimeridis, calabash Chinese herbaceous peony leather (Herba Plantaginis) etc. and so on fresh goods medical herbs decoction on field wing side voluntarily, for heat syndrome diseases caused by exogenous pathogenic factor, this method often can As the medicine took effect, the symptoms lessened, therefore among the peoplely often have saying of " cat fever, Herba Kalimeridis adds Herba Verbenae ".Meet affection by exopathogenic cold-wind, have some inkling of a cold, common people are many can use Rhizoma Zingiberis Recens, Bulbus Allii Fistulosi, the drink-service of brown sugar three warm water, after treating slight perspiration, evil in sweating, spontaneous recovery.Among the people, experience application fresh goods green herbal medicine, although strictly can not follow the principle-method-recipe-medicines principle of the traditional Chinese medical science, on dialectical basis, according to monarch polypharmacy, is enough to illustrate that fresh goods Chinese medicine is extensively at vast Popular Utilization.But, because fresh medicine is extremely inconvenient in storage, processing, transport and use, and perishable inefficacy, therefore the use of fresh medicine is subject to the restriction of epoch and technology, is difficult to be developed in clinical, is even once occurring the phenomenon stagnated.
The application of fresh medicine tradition mainly contains decoction method, natural juice interior oral administration, the way of distillation, soft extracts method, directly mashes application, the outer usage 6 kinds of methods of natural juice.These methods are all now adopt existing use, are confined to Popular Utilization, are substantially not suitable with the needs of modern clinic medication.Therefore, fresh medicine preparation novel form and the new technology of researching and developing efficacy stability, easily storage, applying flexible are the task of top priority.
Summary of the invention
Technical problem to be solved by this invention is, for the deficiencies in the prior art, provides a kind of efficacy stability, effectively the preparation method of the fresh plant free decoction preparation of extraction and protection effective ingredient.
For solving the problems of the technologies described above, the technical solution adopted in the present invention is: the preparation method of fresh plant free decoction preparation, comprises the following steps:
1) by fresh plant Effect of Chinese Medicine Qing wash clean, add in the broken centrifugal device of specialized high-speed and process, obtain fluidised form medical material;
2) take out the fluidised form medical material that step 1) obtains, add the water of its volume 1 ~ 2 times, at 20 ~ 25 DEG C, adopt ultrasonic Treatment;
3) by step 2) filter through the fluidised form medical material of ultrasonic Treatment, obtain filtrate and filtering residue;
4) filtering residue that step 3) obtains is proceeded to step 1) clean up after fresh plant Chinese medicine in, proceed process, filtrate is added in concentrator rapidly and concentrates, then dry, pulverize, obtain fresh plant free decoction preparation.
Preferably, described fresh plant Chinese medicine is the one in fresh Herba Menthae, fresh Herba Lysimachiae, cadmium yellow stilbene, fresh Rhizoma dioscoreae, new lotus leaf and fresh Rhizoma Smilacis Glabrae.
Preferably, the broken centrifugal device of described specialized high-speed, comprise container containing, centrifuge container, broken cutting mechanism, controlling organization and motor, described motor is connected with controlling organization, described container containing is arranged on the outside of centrifuge container, described broken cutting mechanism is arranged in centrifuge container, and drive with motor and be connected, the blade that described broken cutting mechanism comprises rotating shaft and is connected with described rotating shaft, described blade is around described shaft circumference Heterogeneous Permutation, the inwall of described centrifuge container arranges the catch to described centrifuge container bottom angled, the wall of described centrifuge container arranges the filter opening communicated with described container containing, described filter opening flare structure, large mouth is towards the inside of described centrifuge container, the top of described centrifuge container arranges charging aperture, the bottom of described container containing arranges discharging opening.
Preferably, step 2) described in the process conditions of ultrasonic Treatment be: supersonic frequency 20 ~ 30kHz, power 150 ~ 300W, time 8 ~ 15min, number of repetition is 2 ~ 3 times.
Preferably, concentrated described in step 4) is that filtrate is carried out vacuum-concentrcted, and when being concentrated into 60 ~ 80 DEG C, relative density is the mastic of 1.05 ~ 1.13.
Preferably, dry for described mastic is carried out vacuum lyophilization described in step 4).
Preferably, micronizing described in step 4) is, through super micron mill, dried mastic is ground into the fine powder that particle diameter is 10 ~ 75 μm.
Preferably, the present invention also comprises and carries out sterilizing to gained fresh plant free decoction preparation, packaging.
Present invention also offers the application of above-mentioned preparation method gained fresh plant free decoction preparation in compound preparation, fresh plant free decoction preparation is directly added in described compound preparation, make pharmaceutically acceptable dosage form, comprise liquid preparation, granule, tablet, capsule, injection, powder, unguentum, pill.
Preferably, present invention also offers the application of above-mentioned preparation method gained fresh plant free decoction preparation in compound preparation, fresh plant free decoction preparation is directly added in described compound preparation, makes Chinese medicine compound liquid preparation or granule.
Compared with prior art, its beneficial effect is in the present invention:
First the present invention adopts the broken centrifugal device of specialized high-speed to carry out high-speed breakage to fresh plant Chinese crude drug, by the cutting of broken cutting mechanism, effect of impact between material, between material and chamber wall, make the cell wall rupture of Chinese crude drug cell, intracellular effective ingredient flows out, and is then thrown away by fluidised form medical material by centrifugal, collides again with container containing, then converge, discharging; Then ultrasonic Treatment is carried out to the fluidised form medical material of discharging, strengthens further the stripping of effective ingredient, then filter, filtrate is concentrated, dry, then pulverize, sterilizing, packaging, gets product.Whole process control of the present invention is simple, environmental protection, each processing step Synergistic; make preparation method universality of the present invention stronger; extraction efficiency is higher, and active component obtains available protecting, improves the availability of fresh plant Chinese crude drug finished product preferably.
Figure of description
Fig. 1: the structural representation of the broken centrifugal device of a kind of specialized high-speed of the present invention;
Fig. 2: the structural representation of blade in Fig. 1 of the present invention.
Detailed description of the invention
In order to understand the present invention better, set forth content of the present invention below in conjunction with embodiment is clear further, but protection content of the present invention is not only confined to the following examples.
In the following description, a large amount of concrete details is given to provide more thorough understanding of the invention.But, it will be apparent to one skilled in the art that the present invention can be implemented without the need to these details one or more.In other example, in order to avoid obscuring with the present invention, technical characteristics more well known in the art are not described.
Fresh medicine clinically, modal botanical herbs material has Radix et Caulis Opuntiae Dillenii, fresh Rhizoma Phragmitis, fresh Herba Plantaginis, fresh Herba Taraxaci, fresh Rhizoma Acori Graminei, fresh honeysuckle, fresh Radix Polygoni Multiflori, fresh cogongrass, fresh Herba Artemisiae Annuae, fresh Herba Pogostemonis, Rhizoma Zingiberis Recens, fresh Herba Eupatorii, Nodus Nelumbinis Rhizomatis, fresh Herba Setariae Viridis, fresh Herba Equiseti Hiemalis, fresh Herba Peristrophes, fresh Ramulus et Folium Bauhiniae Faberi, fresh Folium cinnamomi camphorae, fresh Herba Dendranthematis indici, fresh Herba Menthae, fresh Herba Lysimachiae, cadmium yellow stilbene, fresh Rhizoma dioscoreae, new lotus leaf, fresh Rhizoma Smilacis Glabrae etc. more than 30 to plant.Said fresh Herba Menthae refers to fresh mint leaf herein.
The invention provides the preparation method of fresh plant free decoction preparation, comprise the following steps:
1) by fresh plant Effect of Chinese Medicine Qing wash clean, add in the broken centrifugal device of specialized high-speed and process, obtain fluidised form medical material;
2) take out the fluidised form medical material that step 1) obtains, add the water of its volume 1 ~ 2 times, at 20 ~ 25 DEG C, adopt ultrasonic Treatment;
3) by step 2) filter through the fluidised form medical material of ultrasonic Treatment, obtain filtrate and filtering residue;
4) filtering residue that step 3) obtains is proceeded to step 1) clean up after fresh plant Chinese medicine in, proceed process, filtrate is added in concentrator rapidly and concentrates, then dry, pulverize, obtain fresh plant free decoction preparation.
One in the present invention in the preferred fresh Herba Menthae of fresh plant Chinese medicine, fresh Herba Lysimachiae, cadmium yellow stilbene, fresh Rhizoma dioscoreae, new lotus leaf, fresh Rhizoma Smilacis Glabrae.
Of the present invention exempt from fried dose be preferably powder, also the powder obtained can be dissolved in any solvent of medically acceptable, be prepared into liquid preparation; Or be combined with medically acceptable adjuvant, be prepared into granule.
In step 1), consult Fig. 1, the broken centrifugal device of described specialized high-speed, comprise container containing 1, centrifuge container 2, broken cutting mechanism, controlling organization and motor 3, motor 3 is connected with controlling organization, container containing 1 is arranged on the outside of centrifuge container 2, broken cutting mechanism is arranged in centrifuge container 2, and drive with motor 3 and be connected, the blade 5 that broken cutting mechanism comprises rotating shaft 4 and is connected with rotating shaft 4, blade 5 is 4 circumference Heterogeneous Permutations around the shaft, the inwall of centrifuge container 2 arranges the catch 6 to centrifuge container 2 bottom angled, the wall of centrifuge container 2 arranges the filter opening 7 communicated with container containing 1, filter opening 7 flare structure, large mouth is towards the inside of centrifuge container 2, the top of centrifuge container 2 arranges charging aperture 8, the bottom of container containing 1 arranges discharging opening 9.Wherein, motor 3 adopts high-speed electric expreess locomotive.Filter opening 7 is tubaeform, and large mouth (one end that namely diameter is large) is towards the inside of centrifuge container 2, and osculum (one end that namely diameter is little) is towards container containing 1, and the diameter of osculum is 0.1 ~ 1 millimeter.Wherein, the blade 5 that broken cutting mechanism comprises rotating shaft 4 and is connected with rotating shaft 4, blade 5 is 4 circumference Heterogeneous Permutations around the shaft.Wherein, rotating shaft exceeds the bottom of centrifuge container, and one end of blade is located in rotating shaft, and blade is around rotating shaft Heterogeneous Permutation between two.As shown in Figure 2, blade 5 is flat, and symmetrical, both sides are arc, and with sharp-pointed sawtooth 10 on arcuate structure.
In step 2) in, the process conditions of described ultrasonic Treatment are: supersonic frequency 20 ~ 30kHz, power 150 ~ 300W, time 8 ~ 15min, and number of repetition is 2 ~ 3 times.Accelerate breaking of cell wall further by ultrasonic Treatment, strengthen the release of intracellular organic matter, diffusion and dissolving.
Concentrated described in step 4) is that filtrate is carried out vacuum-concentrcted, and when being concentrated into 60 ~ 80 DEG C, relative density is the mastic of 1.05 ~ 1.13.This process can be carried out in vacuum-concentrcted equipment, and vacuum-concentrcted can reduce the boiling point of material, increases the temperature difference of steam and storeroom, and improve concentrated speed, thermal loss is few, concentrates at low ambient temperatures, can prevent the loss of heat-sensitive materials.
Dry for described mastic is carried out vacuum lyophilization described in step 4).Concrete, mastic is put into vacuum freeze drier, close hermatic door, open vacuum pump switch and freeze dryer switch, be evacuated to 5kPa ~ 12kPa, start refrigeration simultaneously, in 4 hours, the condenser temperature of vacuum freeze drier is down to-20 DEG C ~-40 DEG C, 1 ~ 3 hour retention time, by heating system, mastic is slowly heated, in 8 ~ 20 hours, mastic is warming up to 0 ~ 12 DEG C, makes mastic dry.
Described in step 4), micronizing is, through super micron mill, dried mastic is ground into the fine powder that particle diameter is 10 ~ 75 μm.Preferred pulverization conditions is: temperature-30 ~-10 DEG C, time 5 ~ 30min, through micronizing, material is under the effects such as impact, collision, shearing, grinding, dispersion, overcome solid interior cohesiveness and make material broken, the dissolution of effective ingredient increases further, and take assimilation effect better, availability is higher.
In addition, the present invention also comprises and carries out sterilizing to gained fresh plant free decoction preparation, packaging.The present invention there is no particular determination to sterilizing, and can be sterilizing methods well known to those skilled in the art, the present invention preferably adopts low temperature sterilization.
Present invention also offers above-mentioned preparation method gained fresh plant free decoction preparation and prepare the application comprised in the compound preparation of fresh plant Chinese medicine, fresh plant free decoction preparation is directly added in described compound preparation, make any pharmaceutically acceptable dosage form, as liquid preparation, granule, tablet, capsule, injection, powder, unguentum or pill.
Below by specific embodiment, those skilled in the art can be implemented.
Embodiment 1
For fresh Herba Menthae, the preparation method of fried dose exempted from by its Chinese medicine, can carry out according to the following steps:
1) cleaned up by fresh Herba Menthae, add in the broken centrifugal device of specialized high-speed and process, obtain fluidised form medical material, wherein, the broken centrifugal device of specialized high-speed is recorded in this article in detail, repeats no more;
2) take out the fluidised form medical material that step 1) obtains, add the water of its volume 1.5 times, at 20 ~ 25 DEG C, adopt ultrasonic Treatment, supersonic frequency is 20kHz, and power is 300W, and the time is 8min, and number of repetition is 2 times;
3) by step 2) filter through the fluidised form medical material of ultrasonic Treatment, obtain filtrate and filtering residue, reduce the contact with air as far as possible;
4) filtering residue that step 3) obtains is proceeded to step 1) clean up after fresh Herba Menthae in, proceed process, filtrate is added rapidly in concentrator and carries out vacuum-concentrcted, when being concentrated into 60 DEG C, relative density is the mastic of 1.05, then vacuum lyophilization is carried out to mastic, dried mastic is ground into the fine powder that particle diameter is 10 ~ 75 μm, obtains fresh Herba Menthae and exempt from fried dose.
The fresh Herba Menthae of gained exempts from fried dose through sterilizing, and packaging, gets product.
Embodiment 2
For fresh Herba Menthae, the preparation method of fried dose exempted from by its Chinese medicine, can carry out according to the following steps:
1) cleaned up by fresh Herba Menthae, add in the broken centrifugal device of specialized high-speed and process, obtain fluidised form medical material, wherein, the broken centrifugal device of specialized high-speed is recorded in this article in detail, repeats no more;
2) take out the fluidised form medical material that step 1) obtains, add the water of its volume 2 times, at 20 ~ 25 DEG C, adopt ultrasonic Treatment, supersonic frequency is 30kHz, and power is 150W, and the time is 15min, and number of repetition is 2 times;
3) by step 2) filter through the fluidised form medical material of ultrasonic Treatment, obtain filtrate and filtering residue, reduce the contact with air as far as possible;
4) filtering residue that step 3) obtains is proceeded to step 1) clean up after fresh Herba Menthae in, proceed process, filtrate is added rapidly in concentrator and carries out vacuum-concentrcted, when being concentrated into 75 DEG C, relative density is the mastic of 1.10, then vacuum lyophilization is carried out to mastic, dried mastic is ground into the fine powder that particle diameter is 10 ~ 75 μm, obtains fresh Herba Menthae and exempt from fried dose.
The fresh Herba Menthae of gained exempts from fried dose through sterilizing, and packaging, gets product.
Embodiment 3
For fresh Herba Lysimachiae, the preparation method of fried dose exempted from by its Chinese medicine, can carry out according to the following steps:
1) cleaned up by fresh Herba Lysimachiae, add in the broken centrifugal device of specialized high-speed and process, obtain fluidised form medical material, wherein, the broken centrifugal device of specialized high-speed is recorded in this article in detail, repeats no more;
2) take out the fluidised form medical material that step 1) obtains, add the water of its volume 1 times, at 20 ~ 25 DEG C, adopt ultrasonic Treatment, supersonic frequency is 30kHz, and power is 200W, and the time is 10min, and number of repetition is 3 times;
3) by step 2) filter through the fluidised form medical material of ultrasonic Treatment, obtain filtrate and filtering residue, reduce the contact with air as far as possible;
4) filtering residue that step 3) obtains is proceeded to step 1) clean up after fresh Herba Lysimachiae in, proceed process, filtrate is added rapidly in concentrator and carries out vacuum-concentrcted, when being concentrated into 65 DEG C, relative density is the mastic of 1.05, then vacuum lyophilization is carried out to mastic, dried mastic is ground into the fine powder that particle diameter is 10 ~ 75 μm, obtains fresh Herba Lysimachiae and exempt from fried dose.
The fresh Herba Lysimachiae of gained exempts from fried dose through sterilizing, and packaging, gets product.
Embodiment 4
For cadmium yellow stilbene, the preparation method of fried dose exempted from by its Chinese medicine, can carry out according to the following steps:
1) cleaned up by cadmium yellow stilbene, add in the broken centrifugal device of specialized high-speed and process, obtain fluidised form medical material, wherein, the broken centrifugal device of specialized high-speed is recorded in this article in detail, repeats no more;
2) take out the fluidised form medical material that step 1) obtains, add the water of its volume 2 times, at 20 ~ 25 DEG C, adopt ultrasonic Treatment, supersonic frequency is 25kHz, and power is 250W, and the time is 8min, and number of repetition is 3 times;
3) by step 2) filter through the fluidised form medical material of ultrasonic Treatment, obtain filtrate and filtering residue, reduce the contact with air as far as possible;
4) filtering residue that step 3) obtains is proceeded to step 1) clean up after cadmium yellow stilbene in, proceed process, filtrate is added rapidly in concentrator and carries out vacuum-concentrcted, when being concentrated into 70 DEG C, relative density is the mastic of 1.11, then vacuum lyophilization is carried out to mastic, dried mastic is ground into the fine powder that particle diameter is 10 ~ 75 μm, obtains cadmium yellow stilbene and exempt from fried dose.
Gained cadmium yellow stilbene exempts from fried dose through sterilizing, and packaging, gets product.
Embodiment 5
For fresh Rhizoma dioscoreae, the preparation method of fried dose exempted from by its Chinese medicine, can carry out according to the following steps:
1) cleaned up by fresh Rhizoma dioscoreae, add in the broken centrifugal device of specialized high-speed and process, obtain fluidised form medical material, wherein, the broken centrifugal device of specialized high-speed is recorded in this article in detail, repeats no more;
2) take out the fluidised form medical material that step 1) obtains, add the water of its volume 1.8 times, at 20 ~ 25 DEG C, adopt ultrasonic Treatment, supersonic frequency is 28kHz, and power is 200W, and the time is 12min, and number of repetition is 2 times;
3) by step 2) filter through the fluidised form medical material of ultrasonic Treatment, obtain filtrate and filtering residue, reduce the contact with air as far as possible;
4) filtering residue that step 3) obtains is proceeded to step 1) clean up after fresh Rhizoma dioscoreae in, proceed process, filtrate is added rapidly in concentrator and carries out vacuum-concentrcted, when being concentrated into 75 DEG C, relative density is the mastic of 1.08, then vacuum lyophilization is carried out to mastic, dried mastic is ground into the fine powder that particle diameter is 10 ~ 75 μm, obtains fresh Rhizoma dioscoreae and exempt from fried dose.
Gained fresh Rhizoma dioscoreae exempts from fried dose through sterilizing, and packaging, gets product.
Embodiment 6
For new lotus leaf, the preparation method of fried dose exempted from by its Chinese medicine, can carry out according to the following steps:
1) cleaned up by new lotus leaf, add in the broken centrifugal device of specialized high-speed and process, obtain fluidised form medical material, wherein, the broken centrifugal device of specialized high-speed is recorded in this article in detail, repeats no more;
2) take out the fluidised form medical material that step 1) obtains, add the water of its volume 2 times, at 20 ~ 25 DEG C, adopt ultrasonic Treatment, supersonic frequency is 20kHz, and power is 280W, and the time is 10min, and number of repetition is 2 times;
3) by step 2) filter through the fluidised form medical material of ultrasonic Treatment, obtain filtrate and filtering residue, reduce the contact with air as far as possible;
4) filtering residue that step 3) obtains is proceeded to step 1) clean up after new lotus leaf in, proceed process, filtrate is added rapidly in concentrator and carries out vacuum-concentrcted, when being concentrated into 65 DEG C, relative density is the mastic of 1.13, then vacuum lyophilization is carried out to mastic, dried mastic is ground into the fine powder that particle diameter is 10 ~ 75 μm, obtains new lotus leaf and exempt from fried dose.
Gained new lotus leaf exempts from fried dose through sterilizing, and packaging, gets product.
Embodiment 7
For fresh Rhizoma Smilacis Glabrae, the preparation method of fried dose exempted from by its Chinese medicine, can carry out according to the following steps:
1) cleaned up by fresh Rhizoma Smilacis Glabrae, add in the broken centrifugal device of specialized high-speed and process, obtain fluidised form medical material, wherein, the broken centrifugal device of specialized high-speed is recorded in this article in detail, repeats no more;
2) take out the fluidised form medical material that step 1) obtains, add the water of its volume 1.5 times, at 20 ~ 25 DEG C, adopt ultrasonic Treatment, supersonic frequency is 25kHz, and power is 250W, and the time is 12min, and number of repetition is 3 times;
3) by step 2) filter through the fluidised form medical material of ultrasonic Treatment, obtain filtrate and filtering residue, reduce the contact with air as far as possible;
4) filtering residue that step 3) obtains is proceeded to step 1) clean up after fresh Rhizoma Smilacis Glabrae in, proceed process, filtrate is added rapidly in concentrator and carries out vacuum-concentrcted, when being concentrated into 70 DEG C, relative density is the mastic of 1.05, then vacuum lyophilization is carried out to mastic, dried mastic is ground into the fine powder that particle diameter is 10 ~ 75 μm, obtains fresh Rhizoma Smilacis Glabrae and exempt from fried dose.
The fresh Rhizoma Smilacis Glabrae of gained exempts from fried dose through sterilizing, and packaging, gets product.
Below by experiment embodiment, beneficial effect of the present invention is described.
Drug efficacy study
1) for a kind of medicine for external use of Acne treatment
Existing Chinese medicine formula: fresh Herba Setariae Viridis 8g, fresh Herba Equiseti Hiemalis 8g, fresh Herba Peristrophes 8g, fresh Ramulus et Folium Bauhiniae Faberi 8g, fresh Folium cinnamomi camphorae 8g, fresh Herba Menthae 6g, fresh Herba Dendranthematis indici 8g, Borneolum Syntheticum 0.8g, 75% ethanol 110g.
Existing method: cleaned by the above-mentioned fresh Chinese herbal medicine material gathered, dry water, loads in the container of clean sterilization by proportioning, add by proportioning the ethanol that content is 75%, sealing, soak 15-30 days, leach medicinal residues, add Borneolum Syntheticum by proportioning in the solution, be designated as liquid preparation I.
The inventive method: each raw material taking said ratio, what obtain each fresh feed according to the inventive method exempts from fried dose, adds by proportioning the ethanol that content is 75%, sealing, soaks 7 days, adds Borneolum Syntheticum in the solution, be designated as liquid preparation II by proportioning.
Lanqin oral solutions:
Observe case totally 80 examples; Wherein man 30 example, female 50 example; 14 ~ 36 years old age, average 2l year; The course of disease 3 months ~ 8 years, average 3 years.Diagnostic criteria is formulated with reference to " Chinese medical disease Standardization of diagnosis and curative effect " and " newly organized Dermatology of Traditional Chinese Medicine ".
Above-mentioned 80 routine patients are divided into 2 groups at random, often organize 40 examples; Apply respectively outside the liquid preparation I (matched group) of same dose and liquid preparation II (experimental group) and put on the skin, day 6 times, repeatedly put 6 times on the skin at every turn, advise avoid drink, delicious food savoury, pungent barbecue dryness-fire food, advise medication further consultation after 3 days, continuous treatment 2 weeks is 1 course for the treatment of. treats 2 courses for the treatment of altogether, observes clinical efficacy.
Evaluation index: recovery from illness: patient skin infringement is disappeared and counted >=95%.Effective: patient skin damages several 70% ~ <95% that disappears.Effective: patient skin damages several 50% ~ <70% that disappears.Invalid: patient skin damages several <50% that disappears.
Shown in clinical efficacy statistical result sees the following form:
Table 1 liang group Clinical efficacy comparison
| Group | Number of cases | Recovery from illness | Effective | Effectively | Invalid |
| Matched group | 40 | 9 | 18 | 11 | 2 |
| Experimental group | 40 | 10 | 22 | 7 | 1 |
Found out by table 1; experimental group is better than matched group; namely the liquid preparation II that the inventive method is made is taken; its curative effect is better than liquid preparation I; method of the present invention is adopted not only not reduce drug effect; and better efficacy, this also illustrates that its drug effect of fresh plant free decoction preparation prepared according to the methods of the invention maintains better, and active component obtains protection preferably and extracts.
2) to treat the Chinese medicine for oral administration granule of hyperlipemia
Existing Chinese medicine formula: fresh Radix Sorghum vulgare Pers. 20g, Receptaculum Helianthi 5g, Fructus Schisandrae Chinensis 4g, fresh winter bamboo shoot 5g, fresh mint leaf 3g, Phyllostachys pubescens Mazei ex H.de Lebaie 5g, American Avocado Tree kernel 3g, fresh cane shoots leaves 3g, Fructus Hordei Germinatus 4g.
Existing method: 1) fresh Radix Sorghum vulgare Pers., fresh winter bamboo shoot, fresh mint leaf and fresh cane shoots leaves are cleaned up, squeeze the juice, filters obtained mixing juice stand-by;
2) be baked to by Phyllostachys pubescens Mazei ex H.de Lebaie and be charred, together send in parcher with Receptaculum Helianthi, Fructus Schisandrae Chinensis, American Avocado Tree kernel and Fructus Hordei Germinatus, bake and parch goes out mixed flavor;
3) step 2) in the good raw material of bake and parch is unified sends into pulverizer, use 90 eye mesh screens to pulverize, and by the raw material blending after pulverizing, obtain powder stand-by;
4) by step 1) in mixing juice adopt spray-dired mode to carry out drying, obtained solid drying thing, by stand-by for solid drying thing;
5) by solid drying and step 3) in powder integrally drop into ball mill, utilize ball mill to be milled to 400 orders, then add Mel furnishing ball, be designated as pill I.
The inventive method: 1) get the fresh Radix Sorghum vulgare Pers. of formulation weight, fresh winter bamboo shoot, fresh cane shoots leaves are prepared into fresh Radix Sorghum vulgare Pers. respectively according to the method for the embodiment of the present invention 7, fresh winter bamboo shoot, fresh cane shoots leaves exempt from fried dose, the fresh mint leaf getting formulation weight is prepared into fresh mint leaf according to the method for the embodiment of the present invention 6 and exempts from fried dose;
2) be baked to by Phyllostachys pubescens Mazei ex H.de Lebaie and be charred, together send in parcher with Receptaculum Helianthi, Fructus Schisandrae Chinensis, American Avocado Tree kernel and Fructus Hordei Germinatus, bake and parch goes out mixed flavor;
3) step 2) in the good raw material of bake and parch is unified sends into pulverizer, use 90 eye mesh screens to pulverize, and by the raw material blending after pulverizing, obtain powder stand-by;
4) the fresh Radix Sorghum vulgare Pers. prepared by step 1), fresh winter bamboo shoot, fresh cane shoots leaves, fresh mint leaf exempt from fried dose with step 3) powder prepared integrally drops into ball mill, utilize ball mill to be milled to 400 orders, then add Mel furnishing ball, be designated as pill II.
Lanqin oral solutions:
Choose 90 routine asthmatics.Be divided into 2 groups at random, often organize 45 examples, 2 groups are compared in sex, age, the course of disease, asthma degree etc., and through statistical procedures, difference there are no significant meaning (P > 0.05), has comparability.
Respectively by taking pill I (matched group) and pill II (experimental group) in identical dosage at one time section, continuous use 2 months is 1 course for the treatment of, observes 2 courses for the treatment of.
Criterion of therapeutical effect: clinical recovery: clinical symptoms, sign disappear or substantially disappear, disease integration reduces >=95%; Effective: clinical symptoms, sign are obviously improved, disease integration reduces >=70%; Take a turn for the better: clinical symptoms, sign all take a favorable turn, disease integration reduces >=30%; Invalid: clinical symptoms, sign are not improved, and even increase the weight of, disease integration reduces less than 30%.
Shown in clinical efficacy statistical result sees the following form:
Table 2 liang group Clinical efficacy comparison
| Group | Number of cases | Recovery from illness | Effective | Take a turn for the better | Invalid |
| Matched group | 45 | 7 | 12 | 20 | 6 |
| Experimental group | 45 | 8 | 15 | 18 | 4 |
As can be seen from Table 2; experimental group curative effect is better than matched group; namely the pill II that the inventive method is made is taken; curative effect is better than pill I; adopt method better efficacy of the present invention; this also further illustrates its drug effect of fresh plant free decoction preparation prepared according to the methods of the invention and maintains better, and active component obtains protection preferably and extracts.
Above-mentioned clinical research can obviously be found out, fresh plant free decoction preparation prepared by the present invention can be applied to prepares compound preparation, namely can be prepared into and comprise the fresh plant Chinese medicine fat/By Chinese Medicines of fresh plant Chinese medicine extract, pill, record in detail in this article; Same, according to record of the present invention, also can be prepared into and comprise the fresh plant Chinese medicine fat/tablet of fresh plant Chinese medicine extract, capsule, injection, powder, unguentum, granule, not enumerate in this application, can prepare under the enlightenment of the application; And evident in efficacy, be obviously better than conventional directly decoction gained Chinese medicine preparation.
Claims (7)
1. the preparation method of fresh plant free decoction preparation, is characterized in that: it comprises the following steps:
1) by fresh plant Effect of Chinese Medicine Qing wash clean, add in the broken centrifugal device of specialized high-speed and process, obtain fluidised form medical material;
2) take out the fluidised form medical material that step 1) obtains, add the water of its volume 1 ~ 2 times, at 20 ~ 25 DEG C, adopt ultrasonic Treatment;
3) by step 2) filter through the fluidised form medical material of ultrasonic Treatment, obtain filtrate and filtering residue;
4) filtering residue that step 3) obtains is proceeded to step 1) clean up after fresh plant Chinese medicine in, proceed process, filtrate is added in concentrator rapidly and concentrates, then dry, pulverize, obtain fresh plant free decoction preparation.
2. the preparation method of fresh plant free decoction preparation as claimed in claim 1, it is characterized in that: the broken centrifugal device of described specialized high-speed, comprise container containing, centrifuge container, broken cutting mechanism, controlling organization and motor, described motor is connected with controlling organization, described container containing is arranged on the outside of centrifuge container, described broken cutting mechanism is arranged in centrifuge container, and drive with motor and be connected, the blade that described broken cutting mechanism comprises rotating shaft and is connected with described rotating shaft, described blade is around described shaft circumference Heterogeneous Permutation, the inwall of described centrifuge container arranges the catch to described centrifuge container bottom angled, the wall of described centrifuge container arranges the filter opening communicated with described container containing, described filter opening flare structure, large mouth is towards the inside of described centrifuge container, the top of described centrifuge container arranges charging aperture, the bottom of described container containing arranges discharging opening.
3. the preparation method of fresh plant free decoction preparation as claimed in claim 1, is characterized in that: step 2) described in the process conditions of ultrasonic Treatment be: supersonic frequency 20 ~ 30kHz, power 150 ~ 300W, time 8 ~ 15min, number of repetition is 2 ~ 3 times.
4. the preparation method of fresh plant free decoction preparation as claimed in claim 1, is characterized in that: concentrated described in step 4) is that filtrate is carried out vacuum-concentrcted, and when being concentrated into 60 ~ 80 DEG C, relative density is the mastic of 1.05 ~ 1.13.
5. the preparation method of fresh plant free decoction preparation as claimed in claim 4, is characterized in that: dry for described mastic is carried out vacuum lyophilization described in step 4).
6. the preparation method of fresh plant free decoction preparation as claimed in claim 5, is characterized in that: micronizing described in step 4) is, through super micron mill, dried mastic is ground into the fine powder that particle diameter is 10 ~ 75 μm.
7. the application of fresh plant free decoction preparation prepared by the preparation method as described in any one of claim 1 ~ 6, it is characterized in that: fresh plant free decoction preparation is directly added in compound preparation, make pharmaceutically acceptable dosage form, comprise liquid preparation, granule, tablet, capsule, injection, powder, unguentum, pill.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106361794A (en) * | 2016-10-20 | 2017-02-01 | 心颐和国际中医药投资控股（北京）有限公司 | Preparation method of decoction-free fresh traditional Chinese medicine |
| WO2020224675A3 (en) * | 2020-07-27 | 2021-02-25 | 苏州巴涛信息科技有限公司 | Air humidifying device |
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| CN101869583A (en) * | 2010-06-23 | 2010-10-27 | 王笑影 | Method for preparing residue-free fresh medicine preparation |
| CN202741209U (en) * | 2012-06-16 | 2013-02-20 | 中国热带农业科学院热带作物品种资源研究所 | Crushing machine for fresh medicinal materials |
| CN203195400U (en) * | 2013-02-05 | 2013-09-18 | 九阳股份有限公司 | Juicing assembly, extrusion-type juicer and knife net centrifugal-type juicer |
| CN104189017A (en) * | 2014-08-13 | 2014-12-10 | 广东高山动物药业有限公司 | Method for processing fresh traditional Chinese medicines |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101869583A (en) * | 2010-06-23 | 2010-10-27 | 王笑影 | Method for preparing residue-free fresh medicine preparation |
| CN202741209U (en) * | 2012-06-16 | 2013-02-20 | 中国热带农业科学院热带作物品种资源研究所 | Crushing machine for fresh medicinal materials |
| CN203195400U (en) * | 2013-02-05 | 2013-09-18 | 九阳股份有限公司 | Juicing assembly, extrusion-type juicer and knife net centrifugal-type juicer |
| CN104189017A (en) * | 2014-08-13 | 2014-12-10 | 广东高山动物药业有限公司 | Method for processing fresh traditional Chinese medicines |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106361794A (en) * | 2016-10-20 | 2017-02-01 | 心颐和国际中医药投资控股（北京）有限公司 | Preparation method of decoction-free fresh traditional Chinese medicine |
| WO2020224675A3 (en) * | 2020-07-27 | 2021-02-25 | 苏州巴涛信息科技有限公司 | Air humidifying device |
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