CN106860758A - Reduce Chinese medicine composition and its application of blood sugar - Google Patents

Abstract

Chinese medicine composition and its application the present invention relates to reduce blood sugar.Said composition includes the component of following weight proportion：5 10 parts of radix scrophulariae, 10 24 parts of the Radix Astragali, 30 38 parts of the root of kudzu vine, 30 40 parts of sealwort, 10 25 parts of manyspike tanoak leaf.Include ultramicro grinding step in its preparation method, be conducive to the dissolution of active ingredient and the absorption of human body.The Chinese medicine composition can play a part of assistant hypoglycemic, comprehensively regulating physical function, treat both principal and secondary aspect of disease, consolidates curative effect.

Description

Reduce Chinese medicine composition and its application of blood sugar

Technical field

The invention belongs to Chinese medicine health-care technical field, and in particular to a kind of Chinese medicine composition of reduction blood sugar and its application.

Background technology

Diabetes are a kind of endocrine and metabolic disorders diseases for being increased with plasma glucose levels and being characterized, and are a kind of and something lost Biography factor and environmental factor interact, multifactor common caused disease.Clinically, diabetes show more than typical three one Few symptom, i.e., many drinks, diuresis, eat more and weight loss symptom, the various complication caused by it disable as patient, lethal One of the main reasons.The disease is difficult to cure, and patient needs Long-term taking medicine, and blood sugar is maintained in normal range (NR) or resistance by medicine Hemostasis sugar is further raised, and delays the exacerbation of the state of an illness and the generation of complication.

At present, the treatment of diabetes is more based on Western medicine, such as sulfonylureas and biguanides, although hypoglycemic effect is rapid, but makees With single, increase pancreas islet burden, and there is the side effects such as hypoglycemia, gastrointestinal reaction, with the extension for the treatment of time, hypoglycemic Effect is in reduction trend, and long-term taking also results in liver kidney toxic and side effect.

Theory of traditional Chinese medical science thinks diabetes spp in category of quenching one's thirst, and it is scorching, bright that its interpretation of the cause, onset and process of an illness essentially consists in lung, stomach, the dirty yin deficiency of kidney three Caused by burning body fluid, the bright water paddy that disappears.Chinese traditional herbs treat diabetes action temperature and lasting, Small side effects, and the mechanism of action has Mutiple Targets, manifold effect, multi-functional Comprehensive Characteristics.

If filtering out the hypoglycemic medicinal material of effective, safety and par from Chinese medicine, the formulation conveniently taken is made into, at it Taken while its drug treatment of diabetic, assistant hypoglycemic can be played, comprehensively regulating physical function is treated both principal and secondary aspect of disease, and consolidates curative effect Effect.

The content of the invention

In view of this, it is an object of the invention to provide a kind of Chinese medicine composition for reducing blood sugar, said composition can be played The effect of assistant hypoglycemic, comprehensively regulating physical function, curative effect for the treatment of both principal and secondary aspect of disease, consolidate.

In order to solve the above technical problems, the technical solution adopted by the present invention is：

It is of the invention reduce blood sugar Chinese medicine composition, including following weight proportion component：5 10 parts of radix scrophulariae, the Radix Astragali 10 24 parts, 30 38 parts of the root of kudzu vine, 30 40 parts of sealwort, 10 25 parts of manyspike tanoak leaf.

Further, the Chinese medicine composition for reducing blood sugar of the invention, preferably includes the component of following weight proportion：Radix scrophulariae 67 parts, 13 17 parts of the Radix Astragali, 32 36 parts of the root of kudzu vine, 34 36 parts of sealwort, 20 24 parts of manyspike tanoak leaf.The reduction blood The Chinese medicine composition of sugar, more preferably including the component of following weight proportion：7 parts of radix scrophulariae, 17 parts of the Radix Astragali, 32 parts of the root of kudzu vine, sealwort 34 Part, 24 parts of manyspike tanoak leaf.

Above-mentioned composition is in a particular application, different depending on specific dosage form, can also add filler, cosolvent, flavoring Agent, bacteriostatic agent etc..

According to《Dictionary of medicinal plant》（Nanjing University of Traditional Chinese Medicine writes, Shanghai science tech publishing house, the second edition), it is described The mechanism of five tastes raw medicinal material is as follows_：Radix scrophulariae, return lung, stomach, kidney channel, with cool blood, nourishing Yin and falling fire, effect of removing toxic substances can be treated Warm heat disease heat enters ying blood, and body heat, polydipsia, tongue is deep red, sends out spot, and hectic fever due to yin labor is coughed, dysphoria is insomnia, and Tianjin hinder constipation, mesh is puckery dim-sighted, and throat swells Bitterly, scrofula subcutaneous nodule, skin sore etc..The Radix Astragali, return lung, the spleen channel, with invigorating qi for strengthening superficies, diuretic and maintain drug, apocenosis, expelling pus and promoting granulation is used In treatment deficiency of vital energy weak, anorexia and loose stool, the sinking of qi of middle-jiao, rush down prolapse of the anus for a long time, uterine bleeding of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy oedema, ulcer is difficult to burst, long Burst and do not hold back, flaccidity of limbs due to deficiency of blood is yellow, Heat Diabetes；Chronic rephrilis protinuria, diabetes.Sealwort, returns spleen, stomach, with Yin nourishing and lung moistening, Invigorate the spleen and benefit qi, effect of Zishen fill fine can treat deficiency of Yin labor and cough, xeropulmonary cough；Insufficiency of the spleen weak, few dry of food is quenched one's thirst；Deficiency of the kidney Soreness and weakness of waist and knees, impotence and seminal emission, tinnitus mesh is dark, and poliosis, physically weak win is thin, wind favus disease etc..The root of kudzu vine, returns spleen, stomach, with solution Flesh is delivered, and is promoted the production of body fluid to quench thirst, effect of Shengyang Zhixie, cures mainly fever caused by exogenous pathogens, rigid and painful head and neck, and measles goes out not smooth, warm disease mouthful from the beginning of, rash Yearningly, diabete, diarrhea, dysentery etc..Manyspike tanoak leaf, with clearing heat and detoxicating, resolving sputum, wind-dispelling, step-down, main damp-heat dysentery, lung heat Cough, ulcer sores, pruitus, hypertension.

Gomi herbs weight proportion in the composition is stated, on the basis of the prepared slices of Chinese crude drugs by processing.Said composition In concrete application, can use traditional decoction form, also can as functional materials add health food in, can also prepare It is the preparation for being easy to preserve and take.Another mesh of the invention is that the protection Chinese medicine composition for reducing blood sugar of the invention exists Prepare the application in Chinese medicine preparation or health products.Specifically, the formulation of the preparation be pill, powder, tablet, capsule, Granule, paste, oral liquid etc..

A kind of method of present invention Chinese medicine composition preparation of preparation using above-mentioned reduction blood sugar presented below, the method has Beneficial to the dissolution of each medicinal material active ingredient in composition, extraction efficiency is high, and the concentrate of preparation also allows for further preparation.

In order to solve the above technical problems, the technical solution adopted by the present invention is：

The method for reducing the Chinese medicine composition preparation of preparation of blood sugar, comprises the following steps：

A, the prepared slices of Chinese crude drugs difference ultramicro grinding for taking manyspike tanoak leaf, radix scrophulariae, the Radix Astragali, the root of kudzu vine and sealwort, obtain medicinal powder；

B, by above-mentioned reduction blood sugar Chinese medicine composition weight proportion, take that the medicinal powder of step A carries out ultrasonic wave or microwave is auxiliary Extraction is helped, extract solution is obtained；

C, the extract solution for taking step B carry out filtering with microporous membrane, concentrate, and obtain concentrate and are obtained final product for preparation.

Further, the preparation method of the prepared slices of Chinese crude drugs of the radix scrophulariae, the Radix Astragali, the root of kudzu vine and sealwort is comprised the following steps：Take profound The fresh medicinal material of ginseng, the Radix Astragali, the root of kudzu vine and sealwort, it is cleaned, dry, stripping and slicing, after degreasing, drying is obtained.

Further, the step A is by medicine materical crude slice ultramicro grinding to 200 mesh or thinner.

Ultramicro grinding described in step A refers to overcome the solid interior cohesiveness to make using mechanical or hydrokinetic method It is broken, material particles more than millimeter can be crushed to the operating technology of micron, thus obtained powder has good molten Xie Xing, dispersiveness, adsorptivity, chemical reactivity etc..Superfine communication technique is used for the present invention, thus obtained medicine powder End, being directly used in preparation has good formulation properties, for further extraction, the extracted amount and extraction efficiency of its active component Also increase.

In above-mentioned preparation method, extracted again after ultramicro grinding, extraction efficiency can be improved, increased the molten of active component Go out；And ungrease treatment is carried out when preparing the prepared slices of Chinese crude drugs to medicinal material, then be conducive to the carrying out of ultramicro grinding.During specific crushing operation, After common grinder preliminary crushing first being used, then required granularity is crushed to micronizer.

Ultrasonic wave extraction described in step B is the special effects such as utilizing the cavitation produced by ultrasonic wave, will be contained in medicine The new extractive technique that chemical composition is quickly and efficiently extracted.Its operating process is_：Add in a reservoir and extract molten Matchmaker's (water, ethanol or other organic solvents etc.), Chinese medicine is crushed as needed or graininess is cut into, and is put into extraction solvent； The outer wall bonding transducer oscillator of container or oscillator is sealed in stainless steel box is put into container；Open supersonic generator, , to ultrasonic wave is sent in extraction solvent, ' cavitation effect ' and mechanism of ultrasonic wave generation in solvent is extracted are on the one hand for oscillator The cell membrane of medicinal material can effectively be crushed, make active ingredient in free state and dissolve in extraction solvent in, on the other hand can accelerate Extract the molecular motion of solvent so that extract the active ingredient Rapid contact in solvent and medicinal material, mutually fused, mixing.Ultrasound Ripple extracts unique advantage low with its Extracting temperature, that recovery rate is high, extraction time is short and is widely used in Chinese medicine and various animal and plant The extraction of effective content, is to substitute traditional shears technique method to realize the modern high technology hand that efficient, energy-saving and environmental protection formula is extracted Section.The microwave auxiliary extraction（MAE), i.e. microwave abstracting, is to absorb the difference of microwave ability so that matrix according to different material Some of some regions or extraction system of material component is selectively heated, so that being extracted material from matrix or body Separated in system, enter into that dielectric constant is smaller, in microwave absorption capacity relative mistake extractant, reach the purpose of extraction.This hair Bright use ultrasonic wave or microwave radiation exaraction, due to the method advantage in itself, and the present composition is in extraction process In synergy, recovery rate and extraction efficiency can be significantly improved.

Filtering with microporous membrane described in step C, also known as secondary filter, is current mainly for separating of submicron particles Most widely used a kind of separation analysis subparticle and ultra-clean degerming means, place small with simple to operate, floor space Without phase transformation and the advantages of new polluter, good separating effect will not be produced during reason.In the method for the present invention, can first to carrying Filtering with microporous membrane is carried out again after taking liquid and carrying out coarse filtration.

Extract solution after filtering can be concentrated by modes such as atmospheric evaporation, reduction vaporization, thin film evaporations.Obtain Concentrate can carry out preparation according to the conventional method of Chinese medicine preparation, be finally made pill, powder, tablet, capsule, granule etc. Various formulations.According to standby specific formulation of drawing up, necessary diluent, adhesive, disintegrant, lubricant etc. can be added.

Further object of the present invention is to provide a kind of Chinese medicine composition using above-mentioned reduction blood sugar to prepare capsule Method, the method operation is simple, and product is stored and takes very convenient.The technical scheme for using for：

The method that the Chinese medicine composition of blood sugar prepares capsule is reduced, is comprised the following steps：

By the weight proportion of the Chinese medicine composition of above-mentioned reduction blood sugar, manyspike tanoak leaf, radix scrophulariae, the Radix Astragali, the root of kudzu vine and Huang are taken respectively The prepared slices of Chinese crude drugs ultramicro grinding of essence, crosses 200 mesh sieves, obtains medicinal powder batch mixing, encapsulated, obtains final product.

Further, the preparation method of the prepared slices of Chinese crude drugs of the radix scrophulariae, the Radix Astragali, the root of kudzu vine and sealwort is comprised the following steps：Take profound The fresh medicinal material of ginseng, the Radix Astragali, the root of kudzu vine and sealwort, it is cleaned, dry, stripping and slicing, after degreasing, drying is obtained.

The ultramicro grinding medicinal powder granularity that the above method is obtained is suitable, not only improves the absorption of human body, there is preferably flowing again Property, it is easy to pharmaceutical practice.As the further improvement of the above method, preferably capsule is prepared into containing medicinal ingredient 0. 3g/ Capsule.

Beneficial effects of the present invention_：The Chinese medicine composition for reducing blood sugar of the invention, it then follows the principle of tcm syndrome differentiation and treatment, All medicine phases and, there is nourishing kidney-YIN, blood sugar is reduced, integration of drinking and medicinal herbs is cheap.By itself and other treatment diabetes Medicine is taken simultaneously, especially as the adjuvant drug or health products of chemical classes antidiabetic drug, can play assistant hypoglycemic, comprehensively regulating Physical function, treats both principal and secondary aspect of disease, and consolidates the effect of curative effect；For having Diabetes family history or three diabetes vulnerable crowds high, will It takes as health products can play a part of to prevent diabetes.The Chinese medicine composition of the reduction blood sugar can be prepared as various doses Type, its preparation method uses superfine communication technique again, makes the product of acquisition and has good dissolubility, dispersiveness, adsorptivity, change Learn reactivity etc., it is easy to follow-up pharmaceutical practice and absorption of human body.The capsule for especially preparing as stated above, operation letter Single, product is stored and takes very convenient.

Specific embodiment

In order that the object, technical solutions and advantages of the present invention are clearer, below to the preferred embodiments of the present invention and Contrast experiment's example is described in detail.

Embodiment 1

Prepare each component by following weight proportion：Radix scrophulariae 10g, Radix Astragali 24g, root of kudzu vine 30g, sealwort 30g, manyspike tanoak leaf 25g. Each component carries out preliminary crushing respectively, carries out ultramicro grinding after crushing again, crosses 200 mesh sieves, and batch mixing is pressed into 0.25g/ pieces, wraps Film-coating, obtains final product.

Embodiment 2

Prepare each component by following weight proportion：Radix scrophulariae 6g, Radix Astragali 18g, root of kudzu vine 36g, sealwort 34g, manyspike tanoak leaf 23g.Respectively Component carries out preliminary crushing respectively, carries out ultramicro grinding after crushing again, crosses 200 mesh sieves, and batch mixing, packing sterilizes, i.e., mouth must dissipate Agent.

Claims (4)

1. the component of the Chinese medicine composition of reduction blood sugar, including following weight proportion：5 10 parts of radix scrophulariae, 10 24 parts of the Radix Astragali, 30 38 parts of the root of kudzu vine, 30 40 parts of sealwort, 10 25 parts of manyspike tanoak leaf.

2. it is according to claim 1 reduce blood sugar Chinese medicine composition, it is characterised in that_：Group including following weight proportion Point：67 parts of radix scrophulariae, 13 17 parts of the Radix Astragali, 32 36 parts of the root of kudzu vine, 34 36 parts of sealwort, 20 24 parts of manyspike tanoak leaf.

3. it is according to claim 1 reduce blood sugar Chinese medicine composition, it is characterised in that：Including following weight proportion Component：7 parts of radix scrophulariae, 17 parts of the Radix Astragali, 32 parts of the root of kudzu vine, 34 parts of sealwort, 24 parts of manyspike tanoak leaf.

4. using the method for the Chinese medicine composition preparation of preparation for reducing blood sugar described in any one of claim 1 to 3, including with Lower step：

A, the prepared slices of Chinese crude drugs difference ultramicro grinding for taking manyspike tanoak leaf, radix scrophulariae, the Radix Astragali, the root of kudzu vine and sealwort, obtain medicinal powder；

B, the weight proportion as described in any one of claims 1 to 3, the medicinal powder for taking step A carry out ultrasonic wave or Microwave-assisted Extraction Take, obtain extract solution；

C, the extract solution for taking step B carry out filtering with microporous membrane, concentrate, and obtain concentrate and are obtained final product for preparation.