CN106729215A - It is a kind of to treat Chinese medicine preparation of osteoarthritis and preparation method thereof - Google Patents
It is a kind of to treat Chinese medicine preparation of osteoarthritis and preparation method thereof Download PDFInfo
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Abstract
Chinese medicine preparation of osteoarthritis and preparation method thereof is treated the invention discloses a kind of, the bulk drug for preparing Chinese medicine preparation is：Faenum graecum, Ficus prmua L. fruitses, broomrape, Eclipta prostrata, cassia seed, tribulus terrestris, dalbergia wood, radix notoginseng, wintergreen, chinaroot greenbrier, amethyst, Longstamen Onion Bulb, rush, Tong puncture vine, lalang grass rhizome.Each medicine compatibility of Chinese medicine preparation of the treatment osteoarthritis that the present invention is prepared is proper, with warm kidney yang-tonifying, invigorates blood circulation the effect of leading to silt, strong muscles and bones, expelling wind and removing dampness, so as to reach the purpose for the treatment of osteoarthritis.
Description
Technical field
The present invention relates to the field of pharmaceutical preparations of traditional herbal medicines, and in particular to a kind of Chinese medicine preparation for treating osteoarthritis and
Its preparation method.
Background technology
Osteoarthritis is a kind of retrogression pathological changes, is due to increasing age, obesity, strain, wound, joint birth defect, pass
Articular cartilage degeneration damage, joint margins and subchondral bone reactive hyperplasia that the factors such as section deformity cause, close also known as bone
Section disease, DA, senescent arthritis, hypertrophiarthritis etc..For the treatment of osteoarthritis, doctor trained in Western medicine is mainly used
Take analgesic type drug, hormone medicine and inject hyaluronic acid, carry out the means such as operative treatment, treatment means specific aim
By force, but for older or weak sufferer, means are excessively fierce, and body is difficult to bear.Accordingly, it would be desirable to using more
It is the treatment means eased up.
Osteoarthritis belongs to " bi Zheng ", " heumatism " category in the traditional Chinese medical science, and clinical manifestation is so that limbs joint is heavy, stiff, pain
Bitterly, very then lopsided tetanic, contraction flexing is main feature.The traditional Chinese medical science thinks, heumatism is that because of deficiency of qi and blood, wind, cold, wet, heat etc. are outer
Heresy is attacked human body, impatency channels and collaterals and causes the disease that QI-blood circulation is not smooth, muscles and bones mistake is foster.Treatment by Chinese herbs heumatism, to tonify the liver and kidney,
The regulation of qi and blood, expelling wind and clearing away cold, dampness removing heat-clearing, promoting blood circulation and removing blood stasis, eleminating phlegm and freeing channels are therapeutic rule.
Chinese patent CN201310336962.X discloses a kind of Chinese medicine for treating knee osteoarthritis, by levisticum, windproof, Du
Secondary, cassia twig, asarum, the radix paeoniae rubrathe, gekko, dipsacus root, frankincense, purslane speedwell, Radix Glycyrrhizae are prepared from as bulk drug.But the patent system is obtained
Chinese medicine it is main based on windproof clearing damp, and osteoarthritis is referred to as non-inflammatory disease, therefore, treat the Chinese medicine of rheumatism to bone
Arthritis does not have therapeutic effect.
Accordingly, it would be desirable to a kind of compatibility is rationally, Chinese medicine preparation of osteoarthritis evident in efficacy and preparation method thereof.
The content of the invention
The present invention is regarding to the issue above, there is provided a kind of to treat Chinese medicine preparation of osteoarthritis and preparation method thereof.
The present invention the used technical scheme that solves the above problems is：A kind of Chinese medicine preparation for treating osteoarthritis, prepares
The bulk drug and its weight portion of Chinese medicine preparation be：20 parts~25 parts of faenum graecum, 5 parts~8 parts of Ficus prmua L. fruitses, 1 part~2 parts of broomrape, drought
3 parts~7 parts of lotus grass, 2 parts~5 parts of cassia seed, 4 parts~8 parts of tribulus terrestris, 5 parts~10 parts of dalbergia wood, 3 parts of radix notoginseng~8 parts, deer hoof
4 parts~8 parts of grass, 2 parts~4 parts of chinaroot greenbrier, 1 part~2 parts of amethyst, 1 part~3 parts of Longstamen Onion Bulb, 1 part~3 parts of rush, 1 part of Tong puncture vine
~3 parts, 0.5 part~2 parts of lalang grass rhizome；Wherein, faenum graecum is frying faenum graecum of the water content no more than 5%；Calcirm-fluoride in amethyst
Content is 90.2%~94.5%.
Wherein, faenum graecum, the big temperature of bitter, enters kidney channel, have the effect of warm kidney sun, by cold-dampness；Ficus prmua L. fruitses, acidic and flat taste,
Invigorate the kidney and stop nocturnal emission, invigorate blood circulation to lead to and become silted up；Broomrape, it is sweet warm in nature, there is strengthening the bones and muscles；Eclipta prostrata, sweet acid cold, enter liver
Kidney channel, there is replenishing vital essence to strengthen the kidney；Cassia seed, sweet-bitter flavor saltiness is slightly cold, enter liver, gallbladder channel, has and lets out liver and gall stagnated fire, dispelling wind and heat from the body clearly
The effect of；Tribulus terrestris, taste is pungent bitterness tepor, enters Liver Channel, there is soothing the liver, soothing the liver, wind-dispelling；Dalbergia wood, taste is pungent is warm in nature, enter liver
Through having the effect of sending down abnormally ascending and warding off dirty, scattered silt；Radix notoginseng, sweet warm in nature, enter liver, stomach have the effect of dissolving stasis, the row stasis of blood and relieve pain；Deer hoof
Grass, bitter is mild-natured, there is wind-damp dispelling, kidney tonifying；Chinaroot greenbrier, it is sweet acid flat, there are expelling wind and removing dampness, swelling and pain relieving；It is purple
Quartz, it is sweet warm in nature, enter the heart, Liver Channel, there are relieving palpitation arresting convulsion, warm lung；Longstamen Onion Bulb, taste is pungent bitterness temperature, enters lung, stomach, large intestine channel,
Have the effect of middle benefit gas activate yang, lower gas dissipating bind；Rush, slightly sweet flavor cold nature enters the heart, small intestinl channel, there is clearing away heat and promoting diuresis；Tong
Puncture vine, it is sweet warm in nature, enter liver and kidney channel, there is kidney tonifying；Lalang grass rhizome, it is sweet cold in nature, enter lung, stomach, there are clearing heat and promoting fluid, cool blood
The effect of；Using faenum graecum, Ficus prmua L. fruitses, broomrape as monarch drug in a prescription, Eclipta prostrata, cassia seed, tribulus terrestris, dalbergia wood as ministerial drug, radix notoginseng,
Used as adjutant, rush, Tong puncture vine, lalang grass rhizome are used as making medicine for wintergreen, chinaroot greenbrier, amethyst, Longstamen Onion Bulb；Each medicine compatibility is proper, has
The effect of silt, strong muscles and bones, expelling wind and removing dampness are led in warm kidney yang-tonifying, promoting blood circulation, so as to reach the purpose for the treatment of osteoarthritis.
Further, the bulk drug and its weight portion for preparing Chinese medicine preparation be：21 parts~23 parts of faenum graecum, 6 parts of Ficus prmua L. fruitses
~8 parts, 1 part~1.6 parts of broomrape, 4 parts~6 parts of Eclipta prostrata, 2 parts~4 parts of cassia seed, 5 parts~7 parts of tribulus terrestris, dalbergia wood 6 parts~8
Part, 4 parts~6 parts of radix notoginseng, 5 parts~7 parts of wintergreen, 3 parts~4 parts of chinaroot greenbrier, 1.5 parts~2 parts of amethyst, 1 part~2 parts of Longstamen Onion Bulb,
2 parts~3 parts of rush, 1.5 parts~3 parts of Tong puncture vine, 1 part~2 parts of lalang grass rhizome.
Further, the bulk drug and its weight portion for preparing Chinese medicine preparation be：22 parts of faenum graecum, 7 parts of Ficus prmua L. fruitses, broomrape
1.5 parts, 5 parts of Eclipta prostrata, 3 parts of cassia seed, 6 parts of tribulus terrestris, 7 parts of dalbergia wood, 5 parts of radix notoginseng, 6 parts of wintergreen, 3.5 parts of chinaroot greenbrier is purple
1.7 parts of quartz, 1.5 parts of Longstamen Onion Bulb, 2.5 parts of rush, 2 parts of Tong puncture vine, 1.5 parts of lalang grass rhizome.
Another goal of the invention of the invention, is to provide a kind of preparation side of the Chinese medicine preparation of above-mentioned treatment osteoarthritis
Method, comprises the following steps：
Step S1, porcelain mortar is respectively placed in by the faenum graecum of the weight portion, Receptaculum Fici Pumilae, cassia seed, tribulus terrestris, Tong puncture vine
In grind into powder I；The broomrape of the weight portion, Eclipta prostrata, wintergreen, chinaroot greenbrier, rush are respectively placed on shearing machine
Shred into the segment II of 15mm~20mm；The dalbergia wood of the weight portion, radix notoginseng, Longstamen Onion Bulb, lalang grass rhizome are respectively placed in crushing mechanism
On be broken into area for 2cm2~5cm2The thin slice III of size；The amethyst of the weight portion is placed in crucible and is crushed, cross 120
Mesh~150 mesh sieve, takes the lower fine powder IV of sieve；Obtained powder I, segment II, thin slice III, fine powder IV are uniformly mixed to get mixing
Medicine, is transferred in earthen container, adds the clear water of 12 times~20 times of mixing medicine weight, is cooked by slow fire 4h~6h, is filtered after closing fire
Medicinal material residue is removed, decocting for Chinese herbal medicine liquid is obtained, is then concentrated under reduced pressure, obtain concentrate；
Step S2, to the absolute ethyl alcohol that 1.1 times~1.3 times of its volume is added in the concentrate that step S1 is obtained, is connected
Continuous extraction 48h~72h, gained extract solution is 75 DEG C~90 DEG C in temperature, and pressure is to be sprayed under conditions of 8MPa~12MPa
Dry, Chinese traditional medicine composition powder is obtained；
Step S3, to adding its own weight 8%~20% pharmaceutically in the Chinese traditional medicine composition powder that step S1 is obtained
Acceptable auxiliary material, is made clinically acceptable preparation, obtains final product the Chinese medicine preparation for the treatment of osteoarthritis.
Further, in step S1, the average grain diameter of powder I is 3mm~8mm.
Further, in step S1, the temperature being cooked by slow fire is 120 DEG C~140 DEG C.
Further, in step S1, the density of concentrate is：4g/mL~10g/mL.
Further, in step S2, the average grain diameter of Chinese traditional medicine composition powder is 20 μm~50 μm.
Further, in step S3, pharmaceutically acceptable auxiliary material is：Icing Sugar, starch, amylum pregelatinisatum, dextrin, breast
Any one in sugar, rubber cement, mannitol, honey, microcrystalline cellulose.
Further, in step S3, clinically acceptable preparation is：Tablet, capsule, powder, dripping pill, honeyed bolus, ball
Any one in agent, granule, soft extract with bee honey agent, injection, ointment, oral liquid formulations.
It is an advantage of the invention that：
1. the Chinese medicine preparation of the obtained treatment osteoarthritis of the present invention using faenum graecum, Ficus prmua L. fruitses, broomrape as monarch drug in a prescription, non-irrigated lotus
Grass, cassia seed, tribulus terrestris, dalbergia wood as ministerial drug, radix notoginseng, wintergreen, chinaroot greenbrier, amethyst, Longstamen Onion Bulb as adjutant, rush,
Tong puncture vine, lalang grass rhizome are used as making medicine；Each medicine compatibility is proper, and the work(of silt, strong muscles and bones, expelling wind and removing dampness is led to warm kidney yang-tonifying, promoting blood circulation
Effect, so as to reach the purpose for the treatment of osteoarthritis；
2. the present invention prepare Chinese medicine preparation method it is easy, easily operated, be conducive to standardization, the scale of tcm product
Production.
Specific embodiment
Embodiments of the invention are described in detail below, but the present invention can be defined by the claims and cover
Multitude of different ways is implemented.
Embodiment 1
A kind of Chinese medicine preparation for treating osteoarthritis, the bulk drug and its weight portion for preparing Chinese medicine preparation be：Faenum graecum 20
Part, 5 parts of Ficus prmua L. fruitses, 1 part of broomrape, 3 parts of Eclipta prostrata, 2 parts of cassia seed, 4 parts of tribulus terrestris, 5 parts of dalbergia wood, 3 parts of radix notoginseng, wintergreen 4
Part, 2 parts of chinaroot greenbrier, 1 part of amethyst, 1 part of Longstamen Onion Bulb, 1 part of rush, 1 part of Tong puncture vine, 0.5 part of lalang grass rhizome；Wherein, faenum graecum is aqueous
Measure the frying faenum graecum for 5%；Calcium Fluoride Content is 90.2% in amethyst.
Embodiment 2
A kind of Chinese medicine preparation for treating osteoarthritis, the bulk drug and its weight portion for preparing Chinese medicine preparation be：Faenum graecum 25
Part, 8 parts of Ficus prmua L. fruitses, 2 parts of broomrape, 7 parts of Eclipta prostrata, 5 parts of cassia seed, 8 parts of tribulus terrestris, 10 parts of dalbergia wood, 8 parts of radix notoginseng, wintergreen 8
Part, 4 parts of chinaroot greenbrier, 2 parts of amethyst, 3 parts of Longstamen Onion Bulb, 3 parts of rush, 3 parts of Tong puncture vine, 2 parts of lalang grass rhizome；Wherein, faenum graecum is water content
It is 2% frying faenum graecum；Calcium Fluoride Content is 94.5% in amethyst.
Embodiment 3
A kind of Chinese medicine preparation for treating osteoarthritis, the bulk drug and its weight portion for preparing Chinese medicine preparation be：Faenum graecum 21
Part, 6 parts of Ficus prmua L. fruitses, 1 part of broomrape, 4 parts of Eclipta prostrata, 2 parts of cassia seed, 5 parts of tribulus terrestris, 6 parts of dalbergia wood, 4 parts of radix notoginseng, wintergreen 5
Part, 3 parts of chinaroot greenbrier, 1.5 parts of amethyst, 1 part of Longstamen Onion Bulb, 2 parts of rush, 1.5 parts of Tong puncture vine, 1 part of lalang grass rhizome；Wherein, faenum graecum be containing
Water is 3% frying faenum graecum；Calcium Fluoride Content is 92.5% in amethyst.
Embodiment 4
A kind of Chinese medicine preparation for treating osteoarthritis, the bulk drug and its weight portion for preparing Chinese medicine preparation be：Faenum graecum 23
Part, 8 parts of Ficus prmua L. fruitses, 1.6 parts of broomrape, 6 parts of Eclipta prostrata, 4 parts of cassia seed, 7 parts of tribulus terrestris, 8 parts of dalbergia wood, 6 parts of radix notoginseng, wintergreen
7 parts, 4 parts of chinaroot greenbrier, 2 parts of amethyst, 2 parts of Longstamen Onion Bulb, 3 parts of rush, 3 parts of Tong puncture vine, 2 parts of lalang grass rhizome；Wherein, faenum graecum is water content
It is 4% frying faenum graecum；Calcium Fluoride Content is 94% in amethyst.
Embodiment 5
A kind of Chinese medicine preparation for treating osteoarthritis, the bulk drug and its weight portion for preparing Chinese medicine preparation be：Faenum graecum 22
Part, 7 parts of Ficus prmua L. fruitses, 1.5 parts of broomrape, 5 parts of Eclipta prostrata, 3 parts of cassia seed, 6 parts of tribulus terrestris, 7 parts of dalbergia wood, 5 parts of radix notoginseng, wintergreen
6 parts, 3.5 parts of chinaroot greenbrier, 1.7 parts of amethyst, 1.5 parts of Longstamen Onion Bulb, 2.5 parts of rush, 2 parts of Tong puncture vine, 1.5 parts of lalang grass rhizome；Wherein, cucurbit
Bar is frying faenum graecum that water content is 3.5%；Calcium Fluoride Content is 93% in amethyst.
Embodiment 6
A kind of preparation method of the Chinese medicine preparation for treating osteoarthritis, comprises the following steps：
Step S1, porcelain mortar is respectively placed in by the faenum graecum of the weight portion, Receptaculum Fici Pumilae, cassia seed, tribulus terrestris, Tong puncture vine
It is middle to grind into the powder I that average grain diameter is 3mm；By the broomrape of the weight portion, Eclipta prostrata, wintergreen, chinaroot greenbrier, rush difference
It is placed on shearing machine and shreds into the segment II of 15mm；The dalbergia wood of the weight portion, radix notoginseng, Longstamen Onion Bulb, lalang grass rhizome are respectively placed in
Area is broken on crushing mechanism for 2cm2The thin slice III of size；The amethyst of the weight portion is placed in crucible and is crushed, mistake
120 mesh sieves, take the lower fine powder IV of sieve；Obtained powder I, segment II, thin slice III, fine powder IV are uniformly mixed to get mixing medicine, are turned
Move in earthen container, add the clear water of 12 times of mixing medicine weight, be cooked by slow fire 4h, medicinal material residue is filtered off after closing fire, obtain
Decocting for Chinese herbal medicine liquid, is then concentrated under reduced pressure, and obtains the concentrate that density is 4g/mL；Wherein, the temperature being cooked by slow fire is 120
℃；
Step S2, to the absolute ethyl alcohol that 1.1 times of its volume is added in the concentrate that step S1 is obtained, is continuously extracted
48h, gained extract solution is 75 DEG C in temperature, and to be spray-dried under conditions of 8MPa, it is 20 μm that average grain diameter is obtained to pressure
Chinese traditional medicine composition powder；
Step S3, to the rubber cement that its own weight 8% is added in the Chinese traditional medicine composition powder that step S1 is obtained, mixing is equal
It is even, mixture powder is granulated, 200 mesh sieves are crossed, 4h is dried under 60 DEG C of temperature conditionss, then diameter is made with tablet press machine
It is 8mm, piece weight is the tablet of 120mg, obtains final product the Chinese medicine preparation for the treatment of osteoarthritis.
Embodiment 7
A kind of preparation method of the Chinese medicine preparation for treating osteoarthritis, comprises the following steps：
Step S1, porcelain mortar is respectively placed in by the faenum graecum of the weight portion, Receptaculum Fici Pumilae, cassia seed, tribulus terrestris, Tong puncture vine
It is middle to grind into the powder I that average grain diameter is 8mm；By the broomrape of the weight portion, Eclipta prostrata, wintergreen, chinaroot greenbrier, rush difference
It is placed on shearing machine and shreds into the segment II of 20mm；The dalbergia wood of the weight portion, radix notoginseng, Longstamen Onion Bulb, lalang grass rhizome are respectively placed in
Area is broken on crushing mechanism for 5cm2The thin slice III of size；The amethyst of the weight portion is placed in crucible and is crushed, mistake
150 mesh sieves, take the lower fine powder IV of sieve；Obtained powder I, segment II, thin slice III, fine powder IV are uniformly mixed to get mixing medicine, are turned
Move in earthen container, add the clear water of 20 times of mixing medicine weight, be cooked by slow fire 6h, medicinal material residue is filtered off after closing fire, obtain
Decocting for Chinese herbal medicine liquid, is then concentrated under reduced pressure, and obtains the concentrate that density is 10g/mL；Wherein, the temperature being cooked by slow fire is 140
℃；
Step S2, to the absolute ethyl alcohol that 1.3 times of its volume is added in the concentrate that step S1 is obtained, is continuously extracted
72h, gained extract solution is 90 DEG C in temperature, and to be spray-dried under conditions of 12MPa, it is 50 μm that average grain diameter is obtained to pressure
Chinese traditional medicine composition powder；
Step S3,112 DEG C are heated to by the honey of Chinese traditional medicine composition powder weight 20%, the glossiness bubble of light red occur
Foam, the viscosity picked up with hand is relatively strong, but without white silk, obtains refined honey；The Chinese traditional medicine composition powder that will be prepared, with refined honey according to 1:
3 mass ratio mechanical mixture in mixer, using peanut oil as lubricant, does imaging surface group sample ball block, using wax bag
Dress, is stored at shady and cool drying, obtains final product pill, obtains final product the Chinese medicine preparation for the treatment of osteoarthritis.
Embodiment 8
A kind of preparation method of the Chinese medicine preparation for treating osteoarthritis, comprises the following steps：
Step S1, porcelain mortar is respectively placed in by the faenum graecum of the weight portion, Receptaculum Fici Pumilae, cassia seed, tribulus terrestris, Tong puncture vine
It is middle to grind into the powder I that average grain diameter is 5mm；By the broomrape of the weight portion, Eclipta prostrata, wintergreen, chinaroot greenbrier, rush difference
It is placed on shearing machine and shreds into the segment II of 18mm；The dalbergia wood of the weight portion, radix notoginseng, Longstamen Onion Bulb, lalang grass rhizome are respectively placed in
Area is broken on crushing mechanism for 3cm2The thin slice III of size；The amethyst of the weight portion is placed in crucible and is crushed, mistake
140 mesh sieves, take the lower fine powder IV of sieve；Obtained powder I, segment II, thin slice III, fine powder IV are uniformly mixed to get mixing medicine, are turned
Move in earthen container, add the clear water of 16 times of mixing medicine weight, be cooked by slow fire 5h, medicinal material residue is filtered off after closing fire, obtain
Decocting for Chinese herbal medicine liquid, is then concentrated under reduced pressure, and obtains the concentrate that density is 8g/mL；Wherein, the temperature being cooked by slow fire is 130
℃；
Step S2, to the absolute ethyl alcohol that 1.2 times of its volume is added in the concentrate that step S1 is obtained, is continuously extracted
60h, gained extract solution is 85 DEG C in temperature, and to be spray-dried under conditions of 10MPa, it is 40 μm that average grain diameter is obtained to pressure
Chinese traditional medicine composition powder；
Step S3, to the dextrin that its own weight 14% is added in the Chinese traditional medicine composition powder that step S1 is obtained, size-reduced,
200 mesh sieves are crossed after uniform mixing, by obtaining powdered after vacuum freeze drying 40h under the temperature conditionss that temperature is -40 DEG C
Preparation, is fitted into one bag of aluminium plastic bag per 30mg powder preparations, obtains final product powder, obtains final product the Chinese medicine preparation for the treatment of osteoarthritis.
Experimental example 1
Select 90 male and female half and half, body weight in the rat of 180g~220g as experimental animal, it is multiple using Hulth molding methods
Rat osteoarthritis processed.90 rats are randomly divided into 9 groups, wherein 10 are only used as control group, 200mg/kg are taken daily
Placebo 2 times, continuous 8 weeks, remaining 80 rat stochastic averagina was divided into 8 groups, as experimental group, 200mg/ is taken daily
Chinese medicine preparation 2 times obtained in kg embodiments 1~8, continuous 8 weeks, 90 other feeding conditions all sames of rat.
Next day each group rat anesthesia after last dose, arteria carotis communis takes blood, centrifuging and taking serum, in ELISA method detection serum
1L-1 β, TNF-α, MMP-1, MMP-3, TIMP-1 content；Each group rat takes condyle articular cartilage in the femur of right side and is fixed on 10% first
In aldehyde, dyeed by decalcification, FFPE, section and HE, row histopathologic examination, and enter according to Mankin ' s standards of grading
Row scoring, appraisal result is as shown in Table 1 and Table 2.
Statistical method：Experimental data is with mean ± standard deviationRepresent, compare between group using single factor test variance point
Analysis, P<0.05 expression difference has statistical significance.
The Chinese medicine preparation of the treatment osteoarthritis that table 1 is prepared is for rat blood serum 1L-1 β, the influence of TNF-α content
Note：Compared with control group, P<0.05.
The Chinese medicine preparation of the treatment osteoarthritis that table 2 is prepared is for rat blood serum MMP-1, MMP-3, TIMP-1 content
Influence
Note：Compared with control group, P<0.05.
As a result：In experimental group 1~8 in rat blood serum 1L-1 β, TNF-α content compared with 1L-1 β in control rats serum,
TNF-α content is substantially reduced, and inhibitory action is notable；In experimental group 1~8 in rat blood serum MMP-1, MMP-3 content compared with control group
MMP-1, MMP-3 content are substantially reduced in rat blood serum, and inhibitory action is obvious；TIMP-1 contains in rat blood serum in experimental group 1~8
Amount is significantly improved compared with TIMP-1 contents in control rats serum, and facilitation is notable.
Conclusion：The Chinese medicine preparation of the treatment osteoarthritis that the application is prepared has significantly treatment for osteoarthritis disorders
Effect.
The preferred embodiments of the present invention are these are only, is not intended to limit the invention, for those skilled in the art
For member, the present invention can have various modifications and variations.All any modifications within the spirit and principles in the present invention, made,
Equivalent, improvement etc., should be included within the scope of the present invention.
Claims (10)
1. a kind of Chinese medicine preparation for treating osteoarthritis, it is characterised in that prepare the bulk drug and its weight of the Chinese medicine preparation
Part it is：20 parts~25 parts of faenum graecum, 5 parts~8 parts of Ficus prmua L. fruitses, 1 part~2 parts of broomrape, 3 parts~7 parts of Eclipta prostrata, cassia seed 2 parts~5
Part, 4 parts~8 parts of tribulus terrestris, 5 parts~10 parts of dalbergia wood, 3 parts~8 parts of radix notoginseng, 4 parts~8 parts of wintergreen, 2 parts~4 parts of chinaroot greenbrier is purple
1 part~2 parts of quartz, 1 part~3 parts of Longstamen Onion Bulb, 1 part~3 parts of rush, 1 part~3 parts of Tong puncture vine, 0.5 part~2 parts of lalang grass rhizome；
Wherein, the faenum graecum is frying faenum graecum of the water content no more than 5%；Calcium Fluoride Content is in the amethyst
90.2%~94.5%.
2. it is according to claim 1 treatment osteoarthritis Chinese medicine preparation, it is characterised in that prepare the Chinese medicine preparation
Bulk drug and its weight portion are：21 parts~23 parts of faenum graecum, 6 parts~8 parts of Ficus prmua L. fruitses, 1 part~1.6 parts of broomrape, 4 parts of Eclipta prostrata~
6 parts, 2 parts~4 parts of cassia seed, 5 parts~7 parts of tribulus terrestris, 6 parts~8 parts of dalbergia wood, 4 parts~6 parts of radix notoginseng, 5 parts~7 parts of wintergreen,
3 parts~4 parts of chinaroot greenbrier, 1.5 parts~2 parts of amethyst, 1 part~2 parts of Longstamen Onion Bulb, 2 parts~3 parts of rush, 1.5 parts of Tong puncture vine~3 parts, thatch
1 part~2 parts of root.
3. it is according to claim 2 treatment osteoarthritis Chinese medicine preparation, it is characterised in that prepare the Chinese medicine preparation
Bulk drug and its weight portion are：22 parts of faenum graecum, 7 parts of Ficus prmua L. fruitses, 1.5 parts of broomrape, 5 parts of Eclipta prostrata, 3 parts of cassia seed, tribulus terrestris 6
Part, 7 parts of dalbergia wood, 5 parts of radix notoginseng, 6 parts of wintergreen, 3.5 parts of chinaroot greenbrier, 1.7 parts of amethyst, 1.5 parts of Longstamen Onion Bulb, 2.5 parts of rush, Tong
2 parts of puncture vine, 1.5 parts of lalang grass rhizome.
4. the preparation method of the Chinese medicine preparation of a kind for the treatment of osteoarthritis according to any one of claims 1 to 3, it is special
Levy and be, comprise the following steps：
Step S1, the faenum graecum of the weight portion, Receptaculum Fici Pumilae, cassia seed, tribulus terrestris, Tong puncture vine are respectively placed in porcelain mortar and ground
It is broken into powder I；The broomrape of the weight portion, Eclipta prostrata, wintergreen, chinaroot greenbrier, rush are respectively placed on shearing machine and are shredded
Into the segment II of 15mm~20mm；The dalbergia wood of the weight portion, radix notoginseng, Longstamen Onion Bulb, lalang grass rhizome are respectively placed on crushing mechanism and are broken
Area is broken into for 2cm2~5cm2The thin slice III of size；The amethyst of the weight portion is placed in crucible and is crushed, 120 mesh excessively~
150 mesh sieves, take the lower fine powder IV of sieve；Obtained powder I, segment II, thin slice III, fine powder IV are uniformly mixed to get mixing medicine, are turned
Move in earthen container, add the clear water of 12 times~20 times of mixing medicine weight, be cooked by slow fire 4h~6h, medicinal material is filtered off after closing fire
Residue, obtains decocting for Chinese herbal medicine liquid, is then concentrated under reduced pressure, and obtains concentrate；
Step S2, to the absolute ethyl alcohol that 1.1 times~1.3 times of its volume is added in the concentrate that step S1 is obtained, is continuously soaked
48h~72h is carried, gained extract solution is 75 DEG C~90 DEG C in temperature, and pressure is dry to carry out spraying under conditions of 8MPa~12MPa
It is dry, Chinese traditional medicine composition powder is obtained；
Step S3, to adding can pharmaceutically connecing for its own weight 8%~20% in the Chinese traditional medicine composition powder that step S1 is obtained
The auxiliary material received, is made clinically acceptable preparation, obtains final product the Chinese medicine preparation of the treatment osteoarthritis.
5. preparation method according to claim 4, it is characterised in that in step S1, the average grain diameter of the powder I is
3mm~8mm.
6. preparation method according to claim 4, it is characterised in that in step S1, the temperature being cooked by slow fire is 120
DEG C~140 DEG C.
7. preparation method according to claim 4, it is characterised in that in step S1, the density of the concentrate is：4g/
ML~10g/mL.
8. preparation method according to claim 4, it is characterised in that in step S2, the Chinese traditional medicine composition powder it is flat
Equal particle diameter is 20 μm~50 μm.
9. preparation method according to claim 4, it is characterised in that in step S3, the pharmaceutically acceptable auxiliary material
For：Any one in Icing Sugar, starch, amylum pregelatinisatum, dextrin, lactose, rubber cement, mannitol, honey, microcrystalline cellulose.
10. preparation method according to claim 4, it is characterised in that in step S3, the clinically acceptable preparation
For：In tablet, capsule, powder, dripping pill, honeyed bolus, pill, granule, soft extract with bee honey agent, injection, ointment, oral liquid formulations
Any one.
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| CN101810739A (en) * | 2009-12-31 | 2010-08-25 | 南京中医药大学 | Anti-osteoarthritis Chinese medicament compound and use thereof |
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| CN101810739A (en) * | 2009-12-31 | 2010-08-25 | 南京中医药大学 | Anti-osteoarthritis Chinese medicament compound and use thereof |
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| CN109966344A (en) * | 2019-05-17 | 2019-07-05 | 陈方妹 | A kind of new application and application method of Chinese herbal medicine climbing fig |
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