CN104116882B - Treat the preparation method of the medicine of hemorrhoid - Google Patents
Treat the preparation method of the medicine of hemorrhoid Download PDFInfo
- Publication number
- CN104116882B CN104116882B CN201410344377.9A CN201410344377A CN104116882B CN 104116882 B CN104116882 B CN 104116882B CN 201410344377 A CN201410344377 A CN 201410344377A CN 104116882 B CN104116882 B CN 104116882B
- Authority
- CN
- China
- Prior art keywords
- relative density
- ethanol
- amount
- filtrate
- concentrated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000003814 drug Substances 0.000 title claims abstract description 69
- 208000014617 hemorrhoid Diseases 0.000 title claims abstract description 40
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- 241000237502 Ostreidae Species 0.000 claims abstract description 31
- 235000020636 oyster Nutrition 0.000 claims abstract description 30
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims abstract description 26
- 235000003140 Panax quinquefolius Nutrition 0.000 claims abstract description 26
- 235000008434 ginseng Nutrition 0.000 claims abstract description 26
- 244000037364 Cinnamomum aromaticum Species 0.000 claims abstract description 24
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 claims abstract description 24
- 241000219784 Sophora Species 0.000 claims abstract description 24
- 238000005242 forging Methods 0.000 claims abstract description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 129
- 239000000706 filtrate Substances 0.000 claims description 49
- 238000001914 filtration Methods 0.000 claims description 46
- 239000000843 powder Substances 0.000 claims description 40
- 241000208340 Araliaceae Species 0.000 claims description 26
- 238000010992 reflux Methods 0.000 claims description 24
- 239000006071 cream Substances 0.000 claims description 18
- 239000000284 extract Substances 0.000 claims description 16
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
- 238000004064 recycling Methods 0.000 claims description 12
- 238000003756 stirring Methods 0.000 claims description 11
- 239000007788 liquid Substances 0.000 claims description 9
- 229920002472 Starch Polymers 0.000 claims description 8
- 239000002775 capsule Substances 0.000 claims description 8
- 235000019359 magnesium stearate Nutrition 0.000 claims description 8
- 239000008107 starch Substances 0.000 claims description 8
- 235000019698 starch Nutrition 0.000 claims description 8
- 239000012141 concentrate Substances 0.000 claims description 7
- 238000005469 granulation Methods 0.000 claims description 6
- 230000003179 granulation Effects 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- 239000007888 film coating Substances 0.000 claims description 5
- 238000009501 film coating Methods 0.000 claims description 5
- 239000008187 granular material Substances 0.000 claims description 5
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 5
- 238000001035 drying Methods 0.000 claims description 4
- -1 tabletting Substances 0.000 claims description 4
- 229920001353 Dextrin Polymers 0.000 claims description 3
- 239000004375 Dextrin Substances 0.000 claims description 3
- 235000019425 dextrin Nutrition 0.000 claims description 3
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 3
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 3
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 3
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 3
- 239000007921 spray Substances 0.000 claims description 3
- 235000020985 whole grains Nutrition 0.000 claims description 3
- 239000002671 adjuvant Substances 0.000 claims description 2
- 239000006187 pill Substances 0.000 claims description 2
- 239000003826 tablet Substances 0.000 claims description 2
- 229940079593 drug Drugs 0.000 abstract description 30
- 239000008280 blood Substances 0.000 abstract description 24
- 210000004369 blood Anatomy 0.000 abstract description 24
- 230000000694 effects Effects 0.000 abstract description 24
- 238000000034 method Methods 0.000 abstract description 22
- 230000000740 bleeding effect Effects 0.000 abstract description 10
- 206010030113 Oedema Diseases 0.000 abstract description 6
- 230000008961 swelling Effects 0.000 abstract description 6
- 210000000436 anus Anatomy 0.000 abstract description 5
- 208000024891 symptom Diseases 0.000 abstract description 5
- 240000008042 Zea mays Species 0.000 abstract description 3
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 abstract description 3
- 235000002017 Zea mays subsp mays Nutrition 0.000 abstract description 3
- 235000005822 corn Nutrition 0.000 abstract description 3
- 231100000331 toxic Toxicity 0.000 abstract description 3
- 230000002588 toxic effect Effects 0.000 abstract description 3
- 244000131316 Panax pseudoginseng Species 0.000 abstract 1
- 201000010099 disease Diseases 0.000 description 15
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 15
- 208000032843 Hemorrhage Diseases 0.000 description 9
- 241000699666 Mus <mouse, genus> Species 0.000 description 9
- 210000004185 liver Anatomy 0.000 description 8
- 231100000614 poison Toxicity 0.000 description 6
- 241000700159 Rattus Species 0.000 description 5
- 230000007812 deficiency Effects 0.000 description 5
- 210000002683 foot Anatomy 0.000 description 5
- 230000023597 hemostasis Effects 0.000 description 5
- 210000000936 intestine Anatomy 0.000 description 5
- 208000002193 Pain Diseases 0.000 description 4
- 230000001914 calming effect Effects 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 238000003304 gavage Methods 0.000 description 4
- 210000003734 kidney Anatomy 0.000 description 4
- 210000004072 lung Anatomy 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 210000000952 spleen Anatomy 0.000 description 4
- 206010010774 Constipation Diseases 0.000 description 3
- 238000012449 Kunming mouse Methods 0.000 description 3
- 206010057071 Rectal tenesmus Diseases 0.000 description 3
- 206010046788 Uterine haemorrhage Diseases 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 210000001124 body fluid Anatomy 0.000 description 3
- 239000010839 body fluid Substances 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 210000002429 large intestine Anatomy 0.000 description 3
- 230000002269 spontaneous effect Effects 0.000 description 3
- 230000035900 sweating Effects 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- 239000003440 toxic substance Substances 0.000 description 3
- 210000003462 vein Anatomy 0.000 description 3
- 206010012735 Diarrhoea Diseases 0.000 description 2
- 206010013911 Dysgeusia Diseases 0.000 description 2
- 208000000059 Dyspnea Diseases 0.000 description 2
- 206010013975 Dyspnoeas Diseases 0.000 description 2
- 101100203936 Mus musculus Srpra gene Proteins 0.000 description 2
- 206010068319 Oropharyngeal pain Diseases 0.000 description 2
- 201000007100 Pharyngitis Diseases 0.000 description 2
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 2
- 238000010171 animal model Methods 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 230000003750 conditioning effect Effects 0.000 description 2
- 230000001276 controlling effect Effects 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 208000002173 dizziness Diseases 0.000 description 2
- 230000004438 eyesight Effects 0.000 description 2
- 230000002650 habitual effect Effects 0.000 description 2
- 208000035861 hematochezia Diseases 0.000 description 2
- 241000411851 herbal medicine Species 0.000 description 2
- 206010022437 insomnia Diseases 0.000 description 2
- 230000009545 invasion Effects 0.000 description 2
- 235000021374 legumes Nutrition 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 231100000957 no side effect Toxicity 0.000 description 2
- 238000004806 packaging method and process Methods 0.000 description 2
- 239000002504 physiological saline solution Substances 0.000 description 2
- 239000002574 poison Substances 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 235000021251 pulses Nutrition 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 238000005728 strengthening Methods 0.000 description 2
- 208000012271 tenesmus Diseases 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 239000011800 void material Substances 0.000 description 2
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 206010000077 Abdominal mass Diseases 0.000 description 1
- 201000000736 Amenorrhea Diseases 0.000 description 1
- 206010001928 Amenorrhoea Diseases 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- 206010003445 Ascites Diseases 0.000 description 1
- 241000208365 Celastraceae Species 0.000 description 1
- 206010010741 Conjunctivitis Diseases 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 241001522252 Crassostrea rivularis Species 0.000 description 1
- 241000234272 Dioscoreaceae Species 0.000 description 1
- 206010013935 Dysmenorrhoea Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 208000010412 Glaucoma Diseases 0.000 description 1
- 206010018498 Goitre Diseases 0.000 description 1
- 208000000616 Hemoptysis Diseases 0.000 description 1
- 208000007514 Herpes zoster Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 208000037093 Menstruation Disturbances Diseases 0.000 description 1
- 206010027339 Menstruation irregular Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 206010029240 Neuritis Diseases 0.000 description 1
- 208000001140 Night Blindness Diseases 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 241001523579 Ostrea Species 0.000 description 1
- 235000002791 Panax Nutrition 0.000 description 1
- 241000208343 Panax Species 0.000 description 1
- 244000046052 Phaseolus vulgaris Species 0.000 description 1
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 1
- 208000012287 Prolapse Diseases 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 208000015815 Rectal disease Diseases 0.000 description 1
- 235000000336 Solanum dulcamara Nutrition 0.000 description 1
- 244000061456 Solanum tuberosum Species 0.000 description 1
- 235000002595 Solanum tuberosum Nutrition 0.000 description 1
- 244000046101 Sophora japonica Species 0.000 description 1
- 235000010586 Sophora japonica Nutrition 0.000 description 1
- 241000123725 Sophora tonkinensis Species 0.000 description 1
- 206010042170 Strangury Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 208000019790 abdominal distention Diseases 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 206010000269 abscess Diseases 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 231100000540 amenorrhea Toxicity 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 239000000679 carrageenan Substances 0.000 description 1
- 235000010418 carrageenan Nutrition 0.000 description 1
- 229920001525 carrageenan Polymers 0.000 description 1
- 229940113118 carrageenan Drugs 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 208000037976 chronic inflammation Diseases 0.000 description 1
- 230000006020 chronic inflammation Effects 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- AZHSSKPUVBVXLK-UHFFFAOYSA-N ethane-1,1-diol Chemical compound CC(O)O AZHSSKPUVBVXLK-UHFFFAOYSA-N 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 208000007565 gingivitis Diseases 0.000 description 1
- 201000003872 goiter Diseases 0.000 description 1
- 208000006750 hematuria Diseases 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 201000001881 impotence Diseases 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000000622 irritating effect Effects 0.000 description 1
- 231100000518 lethal Toxicity 0.000 description 1
- 230000001665 lethal effect Effects 0.000 description 1
- 201000007227 lymph node tuberculosis Diseases 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 206010033675 panniculitis Diseases 0.000 description 1
- 230000007096 poisonous effect Effects 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000000770 proinflammatory effect Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 210000000664 rectum Anatomy 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 210000000697 sensory organ Anatomy 0.000 description 1
- 208000013220 shortness of breath Diseases 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 210000004304 subcutaneous tissue Anatomy 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 230000008736 traumatic injury Effects 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 210000003905 vulva Anatomy 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of preparation method for the medicine for treating hemorrhoid, the medicine is prepared from by dye yam, the Fructus Sophorae, cassia seed, forging oyster, ginseng and subprostrate sophora；Medicine of the present invention has clearing heat for detumescence, the effect of astringing to arrest bleeding.For I, II phase internal piles caused by dampness and heat stasis, symptoms include：Haemorrhoids prolapsus, oedema are rotten to the corn, bleed and penetrate blood, anus swelling.Curative effect of medication prepared by technique of the present invention is compared with Six-element XIAOZHI PIAN prepared by existing standard, is worked rapid, better, and is had no toxic side effect, and is that hemorrhoid patients bring Gospel.
Description
Invention field：
The present invention relates to a kind of preparation method for the medicine for treating hemorrhoid, belong to the field of medicine technology.
Technical background：
Hemorrhoid are multiple common anorectal diseases in life, and clinical onset rate is higher, and medical science meaning hemorrhoid include internal piles, outer
Hemorrhoid, mixed hemorrhoid, are one or more soft veins formed by the veniplex generation varicose of anal orifice and rectal intestine bottom and anal mucosa
Group.It is among the people as the saying goes：" hemorrhoid of ten people nine " hemorrhoid are very big to the harm that patients bring, and bring many to the life of work saturation
Inconvenience, therefore treat in time extremely important.Hemorrhoid when initial, symptom often not substantially, but as haemorrhoids gradually increases, symptom
Also can gradually it aggravate.Clinical common symptom has：Have blood in stool, Silent Neuritis, intermittence have cerise blood to be its feature after an action of the bowels, be also interior
Hemorrhoid or mixed hemorrhoid early stage common sympton, patient often tell " greatly after an action of the bowels blood from anus drop by drop toward flowing down " or " on toilet tissue
All it is blood ".The reason for doctor trained in Western medicine thinks and triggers hemorrhoid is that long-term sitting makes bottom venous return difficult, and hemorrhoidal veins does not have vein
Valve and the upper and lower veniplex wall of rectum it is thin be hemorrhoid formation basis, the direct cause of disease has：Habitual constipation, intra-abdominal pressure increases, directly
Intestines lower end and the chronic inflammation of anal tube, it is long-term to drink and irritative food etc..Using western medicine or operative treatment.Current city
Western medicine emerges in an endless stream on field, makes people too plenty for the eye to take it all in.Western medicine typically takes effect than very fast, but is difficult to eliminate focus, and not thorough.It is long
Phase medication spends high, has side effect to body.Current the most frequently used also most efficient method of western medical treatment hemorrhoid is operation, but hand
Art often spends higher, and also great risk brings other sequelae, is also easy to recurrence.The traditional Chinese medical science thinks the cause of disease of hemorrhoid
The interpretation of the cause, onset and process of an illness is eating and drinking without temperance, and impairing the spleen and stomach, gastrointestine dryness heat hinders Tianjin consumption liquid, dry stool accumulating in the intestine, tenesmus large intestine；Or because of damp invasion of lower energizer, accumulate
Poly- anus, qi depression to blood stasis, tendon and vessel barrier, grain, which relaxes, to be indulged, thus raw hemorrhoid.Using treatment by Chinese herbs.Current Chinese medicine is particular about from outward appearance to inner essence,
Treat both principal and secondary aspect of disease, it is gentle, to have no side effect, cure be thoroughly the traditional advantage of Chinese medicine.Traditional Chinese medicine thinks that tcm therapy generally has finger pressure
Therapy, moxibustion, cupping therapy, Chinese herbal medicine conditioning method etc., and all have no side effect, at present at most also it is most useful that Chinese herbal medicine
Conditioning method, increasing researcher puts forth effort on the Chinese medicine for finding treatment hemorrhoid, and develops the Chinese patent drug use for being made and conveniently taking
In clinic.Six-element XIAOZHI PIAN has clearing heat for detumescence, the effect of astringing to arrest bleeding.For I, II phase internal piles, disease caused by dampness and heat stasis
See：Haemorrhoids prolapsus, oedema are rotten to the corn, bleed and penetrate blood, anus swelling.But inventor has found under study for action, Six-element disappears hemorrhoid
The curative effect of medication of piece is also not reaching to more preferably, therefore, and inventing a kind of preparation method of the Six-element XIAOZHI PIAN of better efficacy has weight
The meaning wanted.
The content of the invention：
The technical problems to be solved by the invention are the preparation for providing a kind of medicine for treating hemorrhoid, i.e. Six-element XIAOZHI PIAN
Method.Medicine prepared by methods described has clearing heat for detumescence, the effect of astringing to arrest bleeding.The medicine ratio that curative effect is prepared with existing standard
Compared with, work rapid, it is better, and have no toxic side effect.
To solve above technical problem, the present invention is realized using following technical scheme：
The medicine for the treatment of hemorrhoid of the present invention is calculated according to composition by weight, by 308 parts of dye yam, 308 parts of the Fructus Sophorae, cassia seed
308 parts, 308 parts of oyster (forging), 77 parts of ginseng, 123 parts of subprostrate sophora be prepared from.
The preparation method of medicine of the treatment hemorrhoid is：Take dye yam, the Fructus Sophorae to be ground into coarse powder, add alcohol reflux and carry
Take, filter, filtrate recycling ethanol is simultaneously condensed into thick paste；Ginseng is ground into coarse powder, adds alcohol reflux and extracts, filtering, filtrate is returned
Receive ethanol and be condensed into thick paste；Remaining cassia seed, oyster and subprostrate sophora smash into coarse powder, add water to cook, and filtration, filtrate is condensed into
Clear cream, is cooled to room temperature, adds ethanol alcohol precipitation, places 24-72 hours, and filtration, filtrate recycling ethanol, decoction is condensed into thick paste；Close
And above-mentioned thick paste, different pharmaceutical preparations can be conventionally made by adding customary adjuvant.
Specifically, the preparation method of the medicine of the treatment hemorrhoid is：Take dye yam, the Fructus Sophorae to be ground into coarse powder, add 30
70% alcohol reflux of amount is extracted 2 times again, each 2h, and filtering reclaims ethanol, relative density is when filtrate is concentrated into 50~60 DEG C
1.34~1.40 thick paste；Ginseng is ground into coarse powder, is extracted 3 times with 6 times of 80% alcohol refluxs of amount, each 1h, filtering merges filter
Liquid, the thick paste that relative density is 1.34~1.40 when reclaiming ethanol and being concentrated into 50~60 DEG C；Remaining cassia seed, oyster and mountain beans
Root is ground into coarse powder, adds water to cook twice, 1.5 hours every time, collecting decoction, filtration, and filtrate concentrates 90~95 DEG C up to relative
Density is 1.14~1.16 clear cream, is cooled to room temperature, plus 2 times of amount ethanol, stirs, place 48 hours, filtration, filtrate is reclaimed
Ethanol, relative density is 1.34~1.40 thick paste when decoction is concentrated into 50~60 DEG C；Merge above-mentioned thick paste, add conventional auxiliary
Different pharmaceutical preparations can be conventionally made in material.
The pharmaceutical preparation refers to tablet, granule, capsule, pill or oral liquid.
The tablet is prepared：Take dye yam, the Fructus Sophorae to be ground into coarse powder, add 30 times of 70% alcohol refluxs of amount and extract 2 times,
Ethanol is reclaimed in each 2h, filtering, and relative density is 1.34~1.40 thick paste when filtrate is concentrated into 50~60 DEG C；Ginseng is crushed
Into coarse powder, extracted 3 times with 6 times of 80% alcohol refluxs of amount, each 1h, filtering, merging filtrate, reclaim ethanol and be concentrated into 50~60
DEG C when relative density be 1.34~1.40 thick paste；Remaining cassia seed, oyster and subprostrate sophora are ground into coarse powder, add water to cook two
Secondary, 1.5 hours every time, collecting decoction, filtration, filtrate concentrated 90~95 DEG C up to the clear cream that relative density is 1.14~1.16,
It is cooled to room temperature, plus 2 times of amount ethanol, stirs, place 48 hours, filtration, filtrate recycling ethanol, decoction is concentrated into 50~60 DEG C
When relative density be 1.34~1.40 thick paste；Merge above-mentioned thick paste, be dried in vacuo, 80 mesh sieves crushed, with 60% ethanol
Granulation, drying, whole grain adds the starch and 0.3% magnesium stearate element of the amount of being made 20%, and tabletting, film coating is produced.
The capsule is prepared：Take dye yam, the Fructus Sophorae to be ground into coarse powder, add 30 times of 70% alcohol refluxs of amount and extract 2
Secondary, ethanol is reclaimed in each 2h, filtering, and relative density is 1.34~1.40 thick paste when filtrate is concentrated into 50~60 DEG C；Ginseng pulverate
Coarse powder is broken into, is extracted 3 times with 6 times of 80% alcohol refluxs of amount, each 1h, filtering, merging filtrate, reclaim and ethanol and be concentrated into 50~
Relative density is 1.34~1.40 thick paste at 60 DEG C；Remaining cassia seed, oyster and subprostrate sophora are ground into coarse powder, add water to cook two
Secondary, 1.5 hours every time, collecting decoction, filtration, filtrate concentrated 90~95 DEG C up to the clear cream that relative density is 1.14~1.16,
It is cooled to room temperature, plus 2 times of amount ethanol, stirs, place 48 hours, filtration, filtrate recycling ethanol, decoction is concentrated into 50~60 DEG C
When relative density be 1.34~1.40 thick paste；Merge above-mentioned thick paste, 60 DEG C dry, pulverize 80 mesh sieves, add the amount of being made
15% starch and 0.5% magnesium stearate, are mixed, and are loaded capsule, are produced.
The granule is prepared：Take dye yam, the Fructus Sophorae to be ground into coarse powder, add 30 times of 70% alcohol refluxs of amount and extract 2
Secondary, ethanol is reclaimed in each 2h, filtering, and relative density is 1.34~1.40 thick paste when filtrate is concentrated into 50~60 DEG C；Ginseng pulverate
Coarse powder is broken into, is extracted 3 times with 6 times of 80% alcohol refluxs of amount, each 1h, filtering, merging filtrate, reclaim and ethanol and be concentrated into 50~
Relative density is 1.34~1.40 thick paste at 60 DEG C；Remaining cassia seed, oyster and subprostrate sophora are ground into coarse powder, add water to cook two
Secondary, 1.5 hours every time, collecting decoction, filtration, filtrate concentrated 90~95 DEG C up to the clear cream that relative density is 1.14~1.16,
It is cooled to room temperature, plus 2 times of amount ethanol, stirs, place 48 hours, filtration, filtrate recycling ethanol, decoction is concentrated into 50~60 DEG C
When relative density be 1.34~1.40 thick paste；Merge above-mentioned thick paste, add the dextrin of the amount of being made 60%, spray into 2% hydroxypropyl
Methylcellulose ethanol 80ml pelletizes, packaging, produces.
Medicine of the present invention is made by including dye yam, the Fructus Sophorae, cassia seed, oyster, ginseng and subprostrate sophora and formed altogether.Wherein, potato
Liang is the stem tuber of Dioscoreaceae plant dye yam.Bitter；It is cool in nature；Mild toxicity.There are promoting blood circulation and hemostasis；Regulating qi-flowing for relieving pain；Clearing heat and detoxicating effect.With
In main hemoptysis；Spitting of blood；Spitting blood；Bleeding from five sense organs or subcutaneous tissue；Hematuria；Have blood in stool；Uterine bleeding；Irregular menstruation；Dysmenorrhoea；Amenorrhea；Postpartum abdominal pain；Abdominal distention；
Erputive abdominal disease；Toxic-heat and blood stasis；Watery diarrhea；Arthralgia；Treating swelling and pain by traumatic injury；Boil；Herpes zoster；The diseases such as traumatism and bleeding.The Fructus Sophorae is pulse family
The fruit of plant Chinese scholartree.Taste bitter and cold, Return liver, large intestine channel.There is heat-clearing, moisten liver, cool blood, effect of hemostasis；Blood is rushed down for controlling intestines wind,
Hemorrhoid blood, uterine bleeding, blood strangury, bloody flux, ambition is unhappy, wind it is dizzy to be fallen, the erosion of vulva is wet the disease such as to itch.Cassia seed be legume Cassia or it is small certainly
Bright dry mature seed.Nature and flavor bitter sweet is cool.Return liver kidney channel, there is clearing liver, improving eyesight, Li Shui, effect of defaecation；For controlling wind
Hot cute conjunctivitis, glaucoma, night blindness, hypertension, hepatitis, cirrhotic ascites, the disease such as habitual constipation.Oyster is that Ostreidae animal length is male
The shell of oyster, ostrea talienwhanensis Crosse or Crassostrea rivularis.Taste cold in nature is salty, Return liver kidney channel.Have calming the liver, transquilization with heavy material, softening and resolving hard mass,
The astringent or styptic treatment for spontaneous sweating effect of convergence；For insomnia of palpitating with fear, scrofula goiter and tumor, abdominal mass lump in the abdomen；Spontaneous sweating；Seminal emission；Uterine bleeding；With inferior disease.People
Join as the dry root of Araliaceae, Panax herbaceos perennial.Its sweet, slight bitter, slightly warm in nature, returns spleen, lung, the heart, kidney channel.Have
Invigorating qi for relieving desertion, strengthening spleen and tonifying lung, calming heart intelligence development, effect of nourishes blood and promotes the production of body fluid；It is usually used in treatment serious disease, prolonged illness, loses blood, takes off member caused by liquid
Gas is intended to take off, refreshing tired weak pulse；The eat less and tired of deficiency of spleen-QI, vomiting and diarrhea；The dyspnea with shortness of breath of insufficiency of lung-QI, coughs powerless；The motive
The insomnia and dreamful sleep that void declines, forgetful, body void hidrosis of palpitating with fear；Body fluid deficiency it is thirsty, quench one's thirst；Sallow, the dizziness of the deficiency of blood；Impotence due to the kidney deficiency, urine
Frequently, the disease such as deficiency of vital energy diseases caused by external factors.Subprostrate sophora is the drying root and rhizome of legume sophora tonkinensis Gapnep.Taste bitter and cold, it is poisonous.Return lung stomach.
Have clearing heat and detoxicating, the effect for relieving sore-throat of subsiding a swelling.Pented up for fiery poison, abscess of throat, the disease such as gingivitis.
Dye yam has promoting blood circulation in side, hemostasis, enriches blood, and qi-regulating is relieved pain, convergence, stop dysentery, removing toxic substances, the effect of detumescence, subprostrate sophora heat-clearing
Removing toxic substances, the effect for relieving sore-throat of subsiding a swelling.Two medicines share to reach the effect of astringing to arrest bleeding removing toxic substances analgesic.Cassia seed heat-clearing improving eyesight, ease constipation
Defaecation.Oyster has calming the liver, transquilization with heavy material, softening and resolving hard mass, restrains astringent or styptic treatment for spontaneous sweating effect, alleviates dry stool accumulating in the intestine, tenesmus large intestine etc.
Disease.The fleshy root of ginseng is famous strong tonic, there is invigorating qi for relieving desertion, strengthening spleen and tonifying lung, calming heart intelligence development, effect of nourishes blood and promotes the production of body fluid.
The Fructus Sophorae has heat-clearing, moistens liver, and cool blood, effect of hemostasis strengthens heat-clearing, and the effect of hemostasis is shared to treat gastrointestine dryness heat, hinders Tianjin
Consume liquid；Or because of damp invasion of lower energizer, accumulate the diseases such as poly- anus.Six medicines, which are shared, can treat I, II phase internal piles caused by dampness and heat stasis, symptoms include
Haemorrhoids prolapses, and oedema is rotten to the corn, bleeds and penetrates blood, rectal tenesmus.
Preparation method of the present invention, can extract the active ingredient that hemorrhoid are treated in medicine to greatest extent,
The purpose of increase efficacy of drugs is reached, while the dosage of patient can also be reduced, mitigates the pain that patient largely takes medicine.
It is below the process of experimental of the present invention：
Experimental example 1：Drug efficacy study
First, to the influence in mouse bleeding time
1. experimental animal:Kunming mice 40, male and female half and half, body weight 18-22g.
2 Experimental agents：
2.1 medicines of the present invention：It is prepared by the method according to the embodiment of the present invention 1.
2.2 control drug：Six-element XIAOZHI PIAN, is prepared according to standard technology.
Prescription：Dye yam 308g, Fructus Sophorae 308g, cassia seed 308g, oyster (forging) 230g, ginseng 77g, subprostrate sophora 123g.
Technique：Above Six-element, takes ginseng, that oyster 77g is ground into fine powder is standby；It is small that remaining oyster adds 6 times of amount decoctings to boil 1
When add the taste of remaining subprostrate sophora etc. four, decoct three times, every time plus 6 times of amount water, decoct 1 hour, merge three decocting liquids, filtration,
Filtrate is concentrated into the clear cream that relative density is 1.30-1.35 (60 DEG C), adds above-mentioned ginseng and oyster fine powder, mixes, and vacuum is done
It is dry, crush, cross 80 mesh sieves, use 60% alcohol granulation, dry, add appropriate amount of starch and 0.3% magnesium stearate, be pressed into 1000
Piece, film coating is produced.
3. experimental method：
Mouse 30 is taken, 3 groups are randomly divided into, gavage gives physiological saline, medicine of the present invention (10g/kg), control drug
(10g/kg), is administered once daily, continuous 6 days.After last dose 1 hour, mouse is respectively placed in fixed bin, cut with profit by
It is cross-section at Mouse Tail-tip 3mm, treat that blood voluntarily overflows beginning timing, drop of blood was suctioned out once with filter paper every 30 seconds, until blood
Naturally untill stopping (without blood when filter paper is inhaled), the bleeding time is calculated, and significance test comparison is carried out using t values method between group.
4. experimental result：
As a result show:Medicine of the present invention can reduce the natural dwell time of bleeding after mouse docking with control drug.Medicine
Group is compared the significant difference having statistically with blank control group.
And medicine group of the present invention is better than control drug group (P<0.05).It is shown in Table 3
Table 3
Note：Compared with blank group, * P<0.05,**P<0.01
Compared with control drug, #P<0.05
2nd, to the influence of rat paw edema degree
1. experimental animal:Healthy SD rat, body weight 180-220g, male and female half and half.
2. Experimental agents：
2.1 medicines of the present invention：It is prepared by the method according to the embodiment of the present invention 1.
2.2 control drug：Six-element XIAOZHI PIAN, is prepared according to standard technology.
Prescription：Dye yam 308g, Fructus Sophorae 308g, cassia seed 308g, oyster (forging) 230g, ginseng 77g, subprostrate sophora 123g.
Technique：Above Six-element, takes ginseng, that oyster 77g is ground into fine powder is standby；It is small that remaining oyster adds 6 times of amount decoctings to boil 1
When add the taste of remaining subprostrate sophora etc. four, decoct three times, every time plus 6 times of amount water, decoct 1 hour, merge three decocting liquids, filtration,
Filtrate is concentrated into the clear cream that relative density is 1.30-1.35 (60 DEG C), adds above-mentioned ginseng and oyster fine powder, mixes, and vacuum is done
It is dry, crush, cross 80 mesh sieves, use 60% alcohol granulation, dry, add appropriate amount of starch and 0.3% magnesium stearate, be pressed into 1000
Piece, film coating is produced.
3. experimental method：
SD rats 30 are taken, 3 groups are randomly divided into, gavage gives physiological saline, medicine of the present invention (5g/kg), control drug
(5g/kg), is administered once daily, continuous 6 days.After last dose 1 hour, vola pedis is held in being determined respectively with volumetric method behind each mouse right side
Product, then at the right carrageenan 011ml of metapedes plantar subcutaneous injection proinflammatory agent 1% of each mouse, once each mouse was determined after cause is scorching every 1 hour
Vola pedis volume behind the right side, calculates pedal swelling rate, and carry out conspicuousness comparison using t values method between group.
4. experimental result：
As a result show:Medicine of the present invention can reduce rat paw edema rate with control drug.Medicine group and blank control
Group more has significant difference statistically.And medicine group of the present invention is better than control drug group (P<0.05).
Table 4
Note：Compared with blank group, * P<0.05,**P<0.01
Compared with control drug, #P<0.05
Conclusion：Test result indicates that, medicine of the present invention can substantially shorten the natural dwell time of bleeding after mouse docking,
Reduce rat paw edema rate.And the curative effect of medicine of the present invention is better than the Six-element XIAOZHI PIAN that standard technology is produced.
Experimental example 3：Anxious poison experimental study
1 experimental method
Kunming mouse, through prerun, to gavage medicine of the present invention of small white mouse, (medicine in the technique of embodiment 1 is extracted
Thing mixture) 1ml/20g, death is not caused, the concentration and administered volume for being limited to medicine can not increase, it is impossible to measure median lethal
Measure (LD50), therefore carry out maximum tolerance determination experiment.
Divide 2 times in the healthy Kunming mouse 20 of selection, weight (20 ± 2) g, male and female half and half, with 24 hours and gavage this
Invention medicine (the drug extract mixture in the technique of embodiment 1, without auxiliary material and preparation part), 1ml/ times, total amount reaches
To 100ml/kg, equivalent to 325g/kg crude drugs.235 times of this dosage equivalent to Coming-of-Age Day dosing.
2 experimental results
Mouse was to observation post administration 7 days, and medicine of the present invention has no adverse reaction, whole bouncings, weight increase, without dead
Die.
Prior art is compared, and the present invention prepares Six-element XIAOZHI PIAN, the medicine that the technique is made from technique of the present invention
Thing is compared with the Six-element XIAOZHI PIAN that primary standard technique is made, and curative effect more preferably, and has no toxic side effect, and has reached goal of the invention.
The present invention is further illustrated by the following examples, but not as limitation of the present invention.
Embodiment：
Embodiment 1
Prescription：Dye yam 308g, Fructus Sophorae 308g, cassia seed 308g, oyster (forging) 308g, ginseng 77g, subprostrate sophora 123g.
Technique：Take dye yam, the Fructus Sophorae to be ground into coarse powder, add 30 times of 70% alcohol refluxs of amount and extract 2 times, each 2h, filtering,
Ethanol is reclaimed, relative density is 1.34~1.40 thick paste when filtrate is concentrated into 50~60 DEG C；Ginseng is ground into coarse powder, with 6 times
Measure 80% alcohol reflux to extract 3 times, each 1h, filtering, merging filtrate, relative density when reclaiming ethanol and being concentrated into 50~60 DEG C
For 1.34~1.40 thick paste；Remaining cassia seed, oyster and subprostrate sophora are ground into coarse powder, add water to cook twice, and 1.5 is small every time
When, collecting decoction, filtration, filtrate concentrates 90~95 DEG C up to the clear cream that relative density is 1.14~1.16, is cooled to room temperature, plus 2
Amount ethanol, stirs again, places 48 hours, filtration, filtrate recycling ethanol, and relative density is when decoction is concentrated into 50~60 DEG C
1.34~1.40 thick paste；Merge above-mentioned thick paste, obtain drug extract mixture；Vacuum drying, crushed 80 mesh sieves, with 60%
Alcohol granulation, drying, whole grain, add the amount of being made 20% starch and 0.3% magnesium stearate element, tabletting, film coating,
Produce tablet.
Specification：Substrate weight 0.3g.
Usage and consumption：Orally, 4 tablets once, 3 times a day.
Embodiment 2
Prescription：Dye yam 308g, Fructus Sophorae 308g, cassia seed 308g, oyster (forging) 308g, ginseng 77g, subprostrate sophora 123g.
Technique：Take dye yam, the Fructus Sophorae to be ground into coarse powder, add 30 times of 70% alcohol refluxs of amount and extract 2 times, each 2h, filtering,
Ethanol is reclaimed, relative density is 1.34~1.40 thick paste when filtrate is concentrated into 50~60 DEG C；Ginseng is ground into coarse powder, with 6 times
Measure 80% alcohol reflux to extract 3 times, each 1h, filtering, merging filtrate, relative density when reclaiming ethanol and being concentrated into 50~60 DEG C
For 1.34~1.40 thick paste；Remaining cassia seed, oyster and subprostrate sophora are ground into coarse powder, add water to cook twice, and 1.5 is small every time
When, collecting decoction, filtration, filtrate concentrates 90~95 DEG C up to the clear cream that relative density is 1.14~1.16, is cooled to room temperature, plus 2
Amount ethanol, stirs again, places 48 hours, filtration, filtrate recycling ethanol, and relative density is when decoction is concentrated into 50~60 DEG C
1.34~1.40 thick paste；Merge above-mentioned thick paste, 60 DEG C dry, pulverize 80 mesh sieves, add the amount of being made 15% starch and
0.5% magnesium stearate, is mixed, and is loaded capsule, is produced capsule.
Specification：0.3g/.
Usage and consumption：Orally, every time 3,3 times a day.
Embodiment 3
Prescription：Dye yam 308g, Fructus Sophorae 308g, cassia seed 308g, oyster (forging) 308g, ginseng 77g, subprostrate sophora 123g.
Technique：Take dye yam, the Fructus Sophorae to be ground into coarse powder, add 30 times of 70% alcohol refluxs of amount and extract 2 times, each 2h, filtering,
Ethanol is reclaimed, relative density is 1.34~1.40 thick paste when filtrate is concentrated into 50~60 DEG C；Ginseng is ground into coarse powder, with 6 times
Measure 80% alcohol reflux to extract 3 times, each 1h, filtering, merging filtrate, relative density when reclaiming ethanol and being concentrated into 50~60 DEG C
For 1.34~1.40 thick paste；Remaining cassia seed, oyster and subprostrate sophora are ground into coarse powder, add water to cook twice, and 1.5 is small every time
When, collecting decoction, filtration, filtrate concentrates 90~95 DEG C up to the clear cream that relative density is 1.14~1.16, is cooled to room temperature, plus 2
Amount ethanol, stirs again, places 48 hours, filtration, filtrate recycling ethanol, and relative density is when decoction is concentrated into 50~60 DEG C
1.34~1.40 thick paste；Merge above-mentioned thick paste, add the dextrin of the amount of being made 60%, spray into 2% hydroxypropyl methyl cellulose second
Alcohol liquid 80ml pelletizes, packaging, produces granule.
Specification：Every bag of 10g.
Usage and consumption：Boiling water is taken after mixing it with water, one time 1 bag, 3 times a day.
Claims (4)
1. a kind of preparation method for the medicine for treating hemorrhoid, it is characterised in that：The medicine of the treatment hemorrhoid is according to composition by weight
Calculate, prepared by 308 parts of dye yam, 308 parts of the Fructus Sophorae, 308 parts of cassia seed, 308 parts of oyster of forging, 77 parts of ginseng, 123 parts of subprostrate sophora and
Into；The preparation method of the medicine is：Take dye yam, the Fructus Sophorae to be ground into coarse powder, add 30 times of 70% alcohol refluxs of amount and extract 2 times,
Ethanol is reclaimed in each 2h, filtering, and relative density is 1.34~1.40 thick paste when filtrate is concentrated into 50~60 DEG C；Ginseng is crushed
Into coarse powder, extracted 3 times with 6 times of 80% alcohol refluxs of amount, each 1h, filtering, merging filtrate, reclaim ethanol and be concentrated into 50~60
DEG C when relative density be 1.34~1.40 thick paste；Remaining cassia seed, oyster and subprostrate sophora are ground into coarse powder, add water to cook two
Secondary, 1.5 hours every time, collecting decoction, filtration, filtrate concentrated 90~95 DEG C up to the clear cream that relative density is 1.14~1.16,
It is cooled to room temperature, plus 2 times of amount ethanol, stirs, place 48 hours, filtration, filtrate recycling ethanol, decoction is concentrated into 50~60 DEG C
When relative density be 1.34~1.40 thick paste；Merge above-mentioned thick paste, add customary adjuvant and difference is conventionally made
Pharmaceutical preparation；The pharmaceutical preparation refers to tablet, granule, capsule, pill or oral liquid.
2. the preparation method of the medicine of hemorrhoid is treated as claimed in claim 1, it is characterised in that：The tablet is prepared：Take
Dye yam, the Fructus Sophorae are ground into coarse powder, add 30 times of 70% alcohol refluxs of amount and extract 2 times, ethanol is reclaimed in each 2h, filtering, and filtrate is dense
Relative density is 1.34~1.40 thick paste when being reduced to 50~60 DEG C；Ginseng is ground into coarse powder, is carried with 6 times of 80% alcohol refluxs of amount
Take 3 times, each 1h, filter, merging filtrate, reclaim ethanol and when being concentrated into 50~60 DEG C relative density for 1.34~1.40 it is thick
Cream；Remaining cassia seed, oyster and subprostrate sophora are ground into coarse powder, add water to cook twice, 1.5 hours every time, collecting decoction, filtration,
Filtrate concentrates 90~95 DEG C up to the clear cream that relative density is 1.14~1.16, is cooled to room temperature, plus 2 times of amount ethanol, and stirring is equal
It is even, place 48 hours, filtration, filtrate recycling ethanol, when decoction is concentrated into 50~60 DEG C relative density for 1.34~1.40 it is thick
Cream；Merge above-mentioned thick paste, be dried in vacuo, crushed 80 mesh sieves, with 60% alcohol granulation, drying, whole grain adds the amount of being made
20% starch and 0.3% magnesium stearate, tabletting, film coating, are produced.
3. the preparation method of the medicine of hemorrhoid is treated as claimed in claim 1, it is characterised in that：The capsule is prepared：
Take dye yam, the Fructus Sophorae to be ground into coarse powder, add 30 times of 70% alcohol refluxs of amount and extract 2 times, ethanol, filtrate are reclaimed in each 2h, filtering
Relative density is 1.34~1.40 thick paste when being concentrated into 50~60 DEG C；Ginseng is ground into coarse powder, with 6 times of 80% alcohol refluxs of amount
Extract 3 times, each 1h, filtering, merging filtrate, relative density is 1.34~1.40 when reclaiming ethanol and being concentrated into 50~60 DEG C
Thick paste；Remaining cassia seed, oyster and subprostrate sophora are ground into coarse powder, add water to cook twice, 1.5 hours every time, collecting decoction, filter
Cross, filtrate concentrates 90~95 DEG C up to the clear cream that relative density is 1.14~1.16, be cooled to room temperature, plus 2 times of amount ethanol, stirring is equal
It is even, place 48 hours, filtration, filtrate recycling ethanol, when decoction is concentrated into 50~60 DEG C relative density for 1.34~1.40 it is thick
Cream；Merge above-mentioned thick paste, 60 DEG C dry, pulverize 80 mesh sieves, add the starch and 0.5% magnesium stearate of the amount of being made 15%,
Mix, load capsule, produce.
4. the preparation method of the medicine of hemorrhoid is treated as claimed in claim 1, it is characterised in that：The granule is prepared：
Take dye yam, the Fructus Sophorae to be ground into coarse powder, add 30 times of 70% alcohol refluxs of amount and extract 2 times, ethanol, filtrate are reclaimed in each 2h, filtering
Relative density is 1.34~1.40 thick paste when being concentrated into 50~60 DEG C；Ginseng is ground into coarse powder, with 6 times of 80% alcohol refluxs of amount
Extract 3 times, each 1h, filtering, merging filtrate, relative density is 1.34~1.40 when reclaiming ethanol and being concentrated into 50~60 DEG C
Thick paste；Remaining cassia seed, oyster and subprostrate sophora are ground into coarse powder, add water to cook twice, 1.5 hours every time, collecting decoction, filter
Cross, filtrate concentrates 90~95 DEG C up to the clear cream that relative density is 1.14~1.16, be cooled to room temperature, plus 2 times of amount ethanol, stirring is equal
It is even, place 48 hours, filtration, filtrate recycling ethanol, when decoction is concentrated into 50~60 DEG C relative density for 1.34~1.40 it is thick
Cream；Merge above-mentioned thick paste, add the dextrin of the amount of being made 60%, spray into 2% hydroxypropyl methyl cellulose ethanol 80m1 granulations, bag
Dress, is produced；The parts by weight are g.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410344377.9A CN104116882B (en) | 2014-07-18 | 2014-07-18 | Treat the preparation method of the medicine of hemorrhoid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410344377.9A CN104116882B (en) | 2014-07-18 | 2014-07-18 | Treat the preparation method of the medicine of hemorrhoid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104116882A CN104116882A (en) | 2014-10-29 |
| CN104116882B true CN104116882B (en) | 2017-08-22 |
Family
ID=51762662
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410344377.9A Active CN104116882B (en) | 2014-07-18 | 2014-07-18 | Treat the preparation method of the medicine of hemorrhoid |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104116882B (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101428109A (en) * | 2008-12-12 | 2009-05-13 | 贵州青草堂药业有限责任公司 | Medicament composition for treating piles and method of preparing the same |
-
2014
- 2014-07-18 CN CN201410344377.9A patent/CN104116882B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101428109A (en) * | 2008-12-12 | 2009-05-13 | 贵州青草堂药业有限责任公司 | Medicament composition for treating piles and method of preparing the same |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104116882A (en) | 2014-10-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103099959B (en) | Traditional Chinese medicine preparation for treating ulcerative colitis and preparation method thereof | |
| CN103432530B (en) | Traditional Chinese medicine composition for treating endometriosis and preparation method thereof | |
| CN104208302A (en) | Fructus rosae laevigatae healthy oral solution for reducing blood fat and preparation method thereof | |
| CN104107299A (en) | Traditional Chinese medicine mixture for treating dysmenorrhoea | |
| CN102078569B (en) | Traditional Chinese medicine preparation for treating liver cancer and preparation method thereof | |
| CN101095923B (en) | Chinese traditional medicine for treating ectopic pregnancy | |
| CN103877438B (en) | Traditional Chinese medicine preparation for treating gout and production method thereof | |
| CN105250619A (en) | Traditional Chinese medicine for treating intrinsic endometriosis and preparation method thereof | |
| CN115779064B (en) | Radix astragali strengthening square, preparation and application thereof | |
| CN104107308B (en) | A kind of medicine for treating hemorrhoid and preparation method thereof | |
| CN103013806B (en) | Health-care therapeutic herbal vinegar | |
| CN105343593A (en) | Spica prunellae health oral liquid capable of decreasing blood pressure and blood lipid as well as preparation method of spica prunellae health oral liquid | |
| CN104043058A (en) | Traditional Chinese medicinal preparation for treating kidney deficiency type lumbar disc herniation and preparation method thereof | |
| CN103656048A (en) | Drug for treating cow mastitis and preparation method thereof | |
| CN104116882B (en) | Treat the preparation method of the medicine of hemorrhoid | |
| CN103157062A (en) | Medicine composition curing gynaecological mass diseases such as fibroids and preparation method and application thereof | |
| CN104758754A (en) | Medicine for treating kidney qi deficiency benign prostate hyperplasia and preparation method thereof | |
| CN104056234A (en) | Drug for dispelling alcohol effect and preparing method thereof | |
| CN104189714A (en) | Traditional Chinese medicine capsule for treating coronary heart disease | |
| CN104189615B (en) | Traditional Chinese medicine preparation for treating metrorrhagia and metrostaxis, and preparation method of traditional Chinese medicine preparation | |
| CN103285360B (en) | Traditional Chinese medicinal preparation for treating thromboangiitis obliterans, and preparation method thereof | |
| CN106729215A (en) | It is a kind of to treat Chinese medicine preparation of osteoarthritis and preparation method thereof | |
| CN104940777A (en) | Electuary capable of treating liver-yang hyperactivity and spleen weakness type diarrhea during menstruation and preparation method thereof | |
| CN104758509A (en) | Medicine for treating qi depression phlegm accumulation type gestational hypertension and preparation method thereof | |
| CN105287829A (en) | Chinese herb composition for treating nephritic syndrome and preparation method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Preparation method of drugs for treating hemorrhoids Effective date of registration: 20231106 Granted publication date: 20170822 Pledgee: Agricultural Bank of China Limited Guiyang Jiaxiu sub branch Pledgor: GUIZHOU RUNSHENG PHARMACY CO.,LTD. Registration number: Y2023520000063 |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right |