CN104116882B - Treat the preparation method of the medicine of hemorrhoid - Google Patents
Treat the preparation method of the medicine of hemorrhoid Download PDFInfo
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- CN104116882B CN104116882B CN201410344377.9A CN201410344377A CN104116882B CN 104116882 B CN104116882 B CN 104116882B CN 201410344377 A CN201410344377 A CN 201410344377A CN 104116882 B CN104116882 B CN 104116882B
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Abstract
The invention discloses a kind of preparation method for the medicine for treating hemorrhoid, the medicine is prepared from by dye yam, the Fructus Sophorae, cassia seed, forging oyster, ginseng and subprostrate sophora;Medicine of the present invention has clearing heat for detumescence, the effect of astringing to arrest bleeding.For I, II phase internal piles caused by dampness and heat stasis, symptoms include:Haemorrhoids prolapsus, oedema are rotten to the corn, bleed and penetrate blood, anus swelling.Curative effect of medication prepared by technique of the present invention is compared with Six-element XIAOZHI PIAN prepared by existing standard, is worked rapid, better, and is had no toxic side effect, and is that hemorrhoid patients bring Gospel.
Description
Invention field:
The present invention relates to a kind of preparation method for the medicine for treating hemorrhoid, belong to the field of medicine technology.
Technical background:
Hemorrhoid are multiple common anorectal diseases in life, and clinical onset rate is higher, and medical science meaning hemorrhoid include internal piles, outer
Hemorrhoid, mixed hemorrhoid, are one or more soft veins formed by the veniplex generation varicose of anal orifice and rectal intestine bottom and anal mucosa
Group.It is among the people as the saying goes:" hemorrhoid of ten people nine " hemorrhoid are very big to the harm that patients bring, and bring many to the life of work saturation
Inconvenience, therefore treat in time extremely important.Hemorrhoid when initial, symptom often not substantially, but as haemorrhoids gradually increases, symptom
Also can gradually it aggravate.Clinical common symptom has:Have blood in stool, Silent Neuritis, intermittence have cerise blood to be its feature after an action of the bowels, be also interior
Hemorrhoid or mixed hemorrhoid early stage common sympton, patient often tell " greatly after an action of the bowels blood from anus drop by drop toward flowing down " or " on toilet tissue
All it is blood ".The reason for doctor trained in Western medicine thinks and triggers hemorrhoid is that long-term sitting makes bottom venous return difficult, and hemorrhoidal veins does not have vein
Valve and the upper and lower veniplex wall of rectum it is thin be hemorrhoid formation basis, the direct cause of disease has:Habitual constipation, intra-abdominal pressure increases, directly
Intestines lower end and the chronic inflammation of anal tube, it is long-term to drink and irritative food etc..Using western medicine or operative treatment.Current city
Western medicine emerges in an endless stream on field, makes people too plenty for the eye to take it all in.Western medicine typically takes effect than very fast, but is difficult to eliminate focus, and not thorough.It is long
Phase medication spends high, has side effect to body.Current the most frequently used also most efficient method of western medical treatment hemorrhoid is operation, but hand
Art often spends higher, and also great risk brings other sequelae, is also easy to recurrence.The traditional Chinese medical science thinks the cause of disease of hemorrhoid
The interpretation of the cause, onset and process of an illness is eating and drinking without temperance, and impairing the spleen and stomach, gastrointestine dryness heat hinders Tianjin consumption liquid, dry stool accumulating in the intestine, tenesmus large intestine;Or because of damp invasion of lower energizer, accumulate
Poly- anus, qi depression to blood stasis, tendon and vessel barrier, grain, which relaxes, to be indulged, thus raw hemorrhoid.Using treatment by Chinese herbs.Current Chinese medicine is particular about from outward appearance to inner essence,
Treat both principal and secondary aspect of disease, it is gentle, to have no side effect, cure be thoroughly the traditional advantage of Chinese medicine.Traditional Chinese medicine thinks that tcm therapy generally has finger pressure
Therapy, moxibustion, cupping therapy, Chinese herbal medicine conditioning method etc., and all have no side effect, at present at most also it is most useful that Chinese herbal medicine
Conditioning method, increasing researcher puts forth effort on the Chinese medicine for finding treatment hemorrhoid, and develops the Chinese patent drug use for being made and conveniently taking
In clinic.Six-element XIAOZHI PIAN has clearing heat for detumescence, the effect of astringing to arrest bleeding.For I, II phase internal piles, disease caused by dampness and heat stasis
See:Haemorrhoids prolapsus, oedema are rotten to the corn, bleed and penetrate blood, anus swelling.But inventor has found under study for action, Six-element disappears hemorrhoid
The curative effect of medication of piece is also not reaching to more preferably, therefore, and inventing a kind of preparation method of the Six-element XIAOZHI PIAN of better efficacy has weight
The meaning wanted.
The content of the invention:
The technical problems to be solved by the invention are the preparation for providing a kind of medicine for treating hemorrhoid, i.e. Six-element XIAOZHI PIAN
Method.Medicine prepared by methods described has clearing heat for detumescence, the effect of astringing to arrest bleeding.The medicine ratio that curative effect is prepared with existing standard
Compared with, work rapid, it is better, and have no toxic side effect.
To solve above technical problem, the present invention is realized using following technical scheme:
The medicine for the treatment of hemorrhoid of the present invention is calculated according to composition by weight, by 308 parts of dye yam, 308 parts of the Fructus Sophorae, cassia seed
308 parts, 308 parts of oyster (forging), 77 parts of ginseng, 123 parts of subprostrate sophora be prepared from.
The preparation method of medicine of the treatment hemorrhoid is:Take dye yam, the Fructus Sophorae to be ground into coarse powder, add alcohol reflux and carry
Take, filter, filtrate recycling ethanol is simultaneously condensed into thick paste;Ginseng is ground into coarse powder, adds alcohol reflux and extracts, filtering, filtrate is returned
Receive ethanol and be condensed into thick paste;Remaining cassia seed, oyster and subprostrate sophora smash into coarse powder, add water to cook, and filtration, filtrate is condensed into
Clear cream, is cooled to room temperature, adds ethanol alcohol precipitation, places 24-72 hours, and filtration, filtrate recycling ethanol, decoction is condensed into thick paste;Close
And above-mentioned thick paste, different pharmaceutical preparations can be conventionally made by adding customary adjuvant.
Specifically, the preparation method of the medicine of the treatment hemorrhoid is:Take dye yam, the Fructus Sophorae to be ground into coarse powder, add 30
70% alcohol reflux of amount is extracted 2 times again, each 2h, and filtering reclaims ethanol, relative density is when filtrate is concentrated into 50~60 DEG C
1.34~1.40 thick paste;Ginseng is ground into coarse powder, is extracted 3 times with 6 times of 80% alcohol refluxs of amount, each 1h, filtering merges filter
Liquid, the thick paste that relative density is 1.34~1.40 when reclaiming ethanol and being concentrated into 50~60 DEG C;Remaining cassia seed, oyster and mountain beans
Root is ground into coarse powder, adds water to cook twice, 1.5 hours every time, collecting decoction, filtration, and filtrate concentrates 90~95 DEG C up to relative
Density is 1.14~1.16 clear cream, is cooled to room temperature, plus 2 times of amount ethanol, stirs, place 48 hours, filtration, filtrate is reclaimed
Ethanol, relative density is 1.34~1.40 thick paste when decoction is concentrated into 50~60 DEG C;Merge above-mentioned thick paste, add conventional auxiliary
Different pharmaceutical preparations can be conventionally made in material.
The pharmaceutical preparation refers to tablet, granule, capsule, pill or oral liquid.
The tablet is prepared:Take dye yam, the Fructus Sophorae to be ground into coarse powder, add 30 times of 70% alcohol refluxs of amount and extract 2 times,
Ethanol is reclaimed in each 2h, filtering, and relative density is 1.34~1.40 thick paste when filtrate is concentrated into 50~60 DEG C;Ginseng is crushed
Into coarse powder, extracted 3 times with 6 times of 80% alcohol refluxs of amount, each 1h, filtering, merging filtrate, reclaim ethanol and be concentrated into 50~60
DEG C when relative density be 1.34~1.40 thick paste;Remaining cassia seed, oyster and subprostrate sophora are ground into coarse powder, add water to cook two
Secondary, 1.5 hours every time, collecting decoction, filtration, filtrate concentrated 90~95 DEG C up to the clear cream that relative density is 1.14~1.16,
It is cooled to room temperature, plus 2 times of amount ethanol, stirs, place 48 hours, filtration, filtrate recycling ethanol, decoction is concentrated into 50~60 DEG C
When relative density be 1.34~1.40 thick paste;Merge above-mentioned thick paste, be dried in vacuo, 80 mesh sieves crushed, with 60% ethanol
Granulation, drying, whole grain adds the starch and 0.3% magnesium stearate element of the amount of being made 20%, and tabletting, film coating is produced.
The capsule is prepared:Take dye yam, the Fructus Sophorae to be ground into coarse powder, add 30 times of 70% alcohol refluxs of amount and extract 2
Secondary, ethanol is reclaimed in each 2h, filtering, and relative density is 1.34~1.40 thick paste when filtrate is concentrated into 50~60 DEG C;Ginseng pulverate
Coarse powder is broken into, is extracted 3 times with 6 times of 80% alcohol refluxs of amount, each 1h, filtering, merging filtrate, reclaim and ethanol and be concentrated into 50~
Relative density is 1.34~1.40 thick paste at 60 DEG C;Remaining cassia seed, oyster and subprostrate sophora are ground into coarse powder, add water to cook two
Secondary, 1.5 hours every time, collecting decoction, filtration, filtrate concentrated 90~95 DEG C up to the clear cream that relative density is 1.14~1.16,
It is cooled to room temperature, plus 2 times of amount ethanol, stirs, place 48 hours, filtration, filtrate recycling ethanol, decoction is concentrated into 50~60 DEG C
When relative density be 1.34~1.40 thick paste;Merge above-mentioned thick paste, 60 DEG C dry, pulverize 80 mesh sieves, add the amount of being made
15% starch and 0.5% magnesium stearate, are mixed, and are loaded capsule, are produced.
The granule is prepared:Take dye yam, the Fructus Sophorae to be ground into coarse powder, add 30 times of 70% alcohol refluxs of amount and extract 2
Secondary, ethanol is reclaimed in each 2h, filtering, and relative density is 1.34~1.40 thick paste when filtrate is concentrated into 50~60 DEG C;Ginseng pulverate
Coarse powder is broken into, is extracted 3 times with 6 times of 80% alcohol refluxs of amount, each 1h, filtering, merging filtrate, reclaim and ethanol and be concentrated into 50~
Relative density is 1.34~1.40 thick paste at 60 DEG C;Remaining cassia seed, oyster and subprostrate sophora are ground into coarse powder, add water to cook two
Secondary, 1.5 hours every time, collecting decoction, filtration, filtrate concentrated 90~95 DEG C up to the clear cream that relative density is 1.14~1.16,
It is cooled to room temperature, plus 2 times of amount ethanol, stirs, place 48 hours, filtration, filtrate recycling ethanol, decoction is concentrated into 50~60 DEG C
When relative density be 1.34~1.40 thick paste;Merge above-mentioned thick paste, add the dextrin of the amount of being made 60%, spray into 2% hydroxypropyl
Methylcellulose ethanol 80ml pelletizes, packaging, produces.
Medicine of the present invention is made by including dye yam, the Fructus Sophorae, cassia seed, oyster, ginseng and subprostrate sophora and formed altogether.Wherein, potato
Liang is the stem tuber of Dioscoreaceae plant dye yam.Bitter;It is cool in nature;Mild toxicity.There are promoting blood circulation and hemostasis;Regulating qi-flowing for relieving pain;Clearing heat and detoxicating effect.With
In main hemoptysis;Spitting of blood;Spitting blood;Bleeding from five sense organs or subcutaneous tissue;Hematuria;Have blood in stool;Uterine bleeding;Irregular menstruation;Dysmenorrhoea;Amenorrhea;Postpartum abdominal pain;Abdominal distention;
Erputive abdominal disease;Toxic-heat and blood stasis;Watery diarrhea;Arthralgia;Treating swelling and pain by traumatic injury;Boil;Herpes zoster;The diseases such as traumatism and bleeding.The Fructus Sophorae is pulse family
The fruit of plant Chinese scholartree.Taste bitter and cold, Return liver, large intestine channel.There is heat-clearing, moisten liver, cool blood, effect of hemostasis;Blood is rushed down for controlling intestines wind,
Hemorrhoid blood, uterine bleeding, blood strangury, bloody flux, ambition is unhappy, wind it is dizzy to be fallen, the erosion of vulva is wet the disease such as to itch.Cassia seed be legume Cassia or it is small certainly
Bright dry mature seed.Nature and flavor bitter sweet is cool.Return liver kidney channel, there is clearing liver, improving eyesight, Li Shui, effect of defaecation;For controlling wind
Hot cute conjunctivitis, glaucoma, night blindness, hypertension, hepatitis, cirrhotic ascites, the disease such as habitual constipation.Oyster is that Ostreidae animal length is male
The shell of oyster, ostrea talienwhanensis Crosse or Crassostrea rivularis.Taste cold in nature is salty, Return liver kidney channel.Have calming the liver, transquilization with heavy material, softening and resolving hard mass,
The astringent or styptic treatment for spontaneous sweating effect of convergence;For insomnia of palpitating with fear, scrofula goiter and tumor, abdominal mass lump in the abdomen;Spontaneous sweating;Seminal emission;Uterine bleeding;With inferior disease.People
Join as the dry root of Araliaceae, Panax herbaceos perennial.Its sweet, slight bitter, slightly warm in nature, returns spleen, lung, the heart, kidney channel.Have
Invigorating qi for relieving desertion, strengthening spleen and tonifying lung, calming heart intelligence development, effect of nourishes blood and promotes the production of body fluid;It is usually used in treatment serious disease, prolonged illness, loses blood, takes off member caused by liquid
Gas is intended to take off, refreshing tired weak pulse;The eat less and tired of deficiency of spleen-QI, vomiting and diarrhea;The dyspnea with shortness of breath of insufficiency of lung-QI, coughs powerless;The motive
The insomnia and dreamful sleep that void declines, forgetful, body void hidrosis of palpitating with fear;Body fluid deficiency it is thirsty, quench one's thirst;Sallow, the dizziness of the deficiency of blood;Impotence due to the kidney deficiency, urine
Frequently, the disease such as deficiency of vital energy diseases caused by external factors.Subprostrate sophora is the drying root and rhizome of legume sophora tonkinensis Gapnep.Taste bitter and cold, it is poisonous.Return lung stomach.
Have clearing heat and detoxicating, the effect for relieving sore-throat of subsiding a swelling.Pented up for fiery poison, abscess of throat, the disease such as gingivitis.
Dye yam has promoting blood circulation in side, hemostasis, enriches blood, and qi-regulating is relieved pain, convergence, stop dysentery, removing toxic substances, the effect of detumescence, subprostrate sophora heat-clearing
Removing toxic substances, the effect for relieving sore-throat of subsiding a swelling.Two medicines share to reach the effect of astringing to arrest bleeding removing toxic substances analgesic.Cassia seed heat-clearing improving eyesight, ease constipation
Defaecation.Oyster has calming the liver, transquilization with heavy material, softening and resolving hard mass, restrains astringent or styptic treatment for spontaneous sweating effect, alleviates dry stool accumulating in the intestine, tenesmus large intestine etc.
Disease.The fleshy root of ginseng is famous strong tonic, there is invigorating qi for relieving desertion, strengthening spleen and tonifying lung, calming heart intelligence development, effect of nourishes blood and promotes the production of body fluid.
The Fructus Sophorae has heat-clearing, moistens liver, and cool blood, effect of hemostasis strengthens heat-clearing, and the effect of hemostasis is shared to treat gastrointestine dryness heat, hinders Tianjin
Consume liquid;Or because of damp invasion of lower energizer, accumulate the diseases such as poly- anus.Six medicines, which are shared, can treat I, II phase internal piles caused by dampness and heat stasis, symptoms include
Haemorrhoids prolapses, and oedema is rotten to the corn, bleeds and penetrates blood, rectal tenesmus.
Preparation method of the present invention, can extract the active ingredient that hemorrhoid are treated in medicine to greatest extent,
The purpose of increase efficacy of drugs is reached, while the dosage of patient can also be reduced, mitigates the pain that patient largely takes medicine.
It is below the process of experimental of the present invention:
Experimental example 1:Drug efficacy study
First, to the influence in mouse bleeding time
1. experimental animal:Kunming mice 40, male and female half and half, body weight 18-22g.
2 Experimental agents:
2.1 medicines of the present invention:It is prepared by the method according to the embodiment of the present invention 1.
2.2 control drug:Six-element XIAOZHI PIAN, is prepared according to standard technology.
Prescription:Dye yam 308g, Fructus Sophorae 308g, cassia seed 308g, oyster (forging) 230g, ginseng 77g, subprostrate sophora 123g.
Technique:Above Six-element, takes ginseng, that oyster 77g is ground into fine powder is standby;It is small that remaining oyster adds 6 times of amount decoctings to boil 1
When add the taste of remaining subprostrate sophora etc. four, decoct three times, every time plus 6 times of amount water, decoct 1 hour, merge three decocting liquids, filtration,
Filtrate is concentrated into the clear cream that relative density is 1.30-1.35 (60 DEG C), adds above-mentioned ginseng and oyster fine powder, mixes, and vacuum is done
It is dry, crush, cross 80 mesh sieves, use 60% alcohol granulation, dry, add appropriate amount of starch and 0.3% magnesium stearate, be pressed into 1000
Piece, film coating is produced.
3. experimental method:
Mouse 30 is taken, 3 groups are randomly divided into, gavage gives physiological saline, medicine of the present invention (10g/kg), control drug
(10g/kg), is administered once daily, continuous 6 days.After last dose 1 hour, mouse is respectively placed in fixed bin, cut with profit by
It is cross-section at Mouse Tail-tip 3mm, treat that blood voluntarily overflows beginning timing, drop of blood was suctioned out once with filter paper every 30 seconds, until blood
Naturally untill stopping (without blood when filter paper is inhaled), the bleeding time is calculated, and significance test comparison is carried out using t values method between group.
4. experimental result:
As a result show:Medicine of the present invention can reduce the natural dwell time of bleeding after mouse docking with control drug.Medicine
Group is compared the significant difference having statistically with blank control group.
And medicine group of the present invention is better than control drug group (P<0.05).It is shown in Table 3
Table 3
Note:Compared with blank group, * P<0.05,**P<0.01
Compared with control drug, #P<0.05
2nd, to the influence of rat paw edema degree
1. experimental animal:Healthy SD rat, body weight 180-220g, male and female half and half.
2. Experimental agents:
2.1 medicines of the present invention:It is prepared by the method according to the embodiment of the present invention 1.
2.2 control drug:Six-element XIAOZHI PIAN, is prepared according to standard technology.
Prescription:Dye yam 308g, Fructus Sophorae 308g, cassia seed 308g, oyster (forging) 230g, ginseng 77g, subprostrate sophora 123g.
Technique:Above Six-element, takes ginseng, that oyster 77g is ground into fine powder is standby;It is small that remaining oyster adds 6 times of amount decoctings to boil 1
When add the taste of remaining subprostrate sophora etc. four, decoct three times, every time plus 6 times of amount water, decoct 1 hour, merge three decocting liquids, filtration,
Filtrate is concentrated into the clear cream that relative density is 1.30-1.35 (60 DEG C), adds above-mentioned ginseng and oyster fine powder, mixes, and vacuum is done
It is dry, crush, cross 80 mesh sieves, use 60% alcohol granulation, dry, add appropriate amount of starch and 0.3% magnesium stearate, be pressed into 1000
Piece, film coating is produced.
3. experimental method:
SD rats 30 are taken, 3 groups are randomly divided into, gavage gives physiological saline, medicine of the present invention (5g/kg), control drug
(5g/kg), is administered once daily, continuous 6 days.After last dose 1 hour, vola pedis is held in being determined respectively with volumetric method behind each mouse right side
Product, then at the right carrageenan 011ml of metapedes plantar subcutaneous injection proinflammatory agent 1% of each mouse, once each mouse was determined after cause is scorching every 1 hour
Vola pedis volume behind the right side, calculates pedal swelling rate, and carry out conspicuousness comparison using t values method between group.
4. experimental result:
As a result show:Medicine of the present invention can reduce rat paw edema rate with control drug.Medicine group and blank control
Group more has significant difference statistically.And medicine group of the present invention is better than control drug group (P<0.05).
Table 4
Note:Compared with blank group, * P<0.05,**P<0.01
Compared with control drug, #P<0.05
Conclusion:Test result indicates that, medicine of the present invention can substantially shorten the natural dwell time of bleeding after mouse docking,
Reduce rat paw edema rate.And the curative effect of medicine of the present invention is better than the Six-element XIAOZHI PIAN that standard technology is produced.
Experimental example 3:Anxious poison experimental study
1 experimental method
Kunming mouse, through prerun, to gavage medicine of the present invention of small white mouse, (medicine in the technique of embodiment 1 is extracted
Thing mixture) 1ml/20g, death is not caused, the concentration and administered volume for being limited to medicine can not increase, it is impossible to measure median lethal
Measure (LD50), therefore carry out maximum tolerance determination experiment.
Divide 2 times in the healthy Kunming mouse 20 of selection, weight (20 ± 2) g, male and female half and half, with 24 hours and gavage this
Invention medicine (the drug extract mixture in the technique of embodiment 1, without auxiliary material and preparation part), 1ml/ times, total amount reaches
To 100ml/kg, equivalent to 325g/kg crude drugs.235 times of this dosage equivalent to Coming-of-Age Day dosing.
2 experimental results
Mouse was to observation post administration 7 days, and medicine of the present invention has no adverse reaction, whole bouncings, weight increase, without dead
Die.
Prior art is compared, and the present invention prepares Six-element XIAOZHI PIAN, the medicine that the technique is made from technique of the present invention
Thing is compared with the Six-element XIAOZHI PIAN that primary standard technique is made, and curative effect more preferably, and has no toxic side effect, and has reached goal of the invention.
The present invention is further illustrated by the following examples, but not as limitation of the present invention.
Embodiment:
Embodiment 1
Prescription:Dye yam 308g, Fructus Sophorae 308g, cassia seed 308g, oyster (forging) 308g, ginseng 77g, subprostrate sophora 123g.
Technique:Take dye yam, the Fructus Sophorae to be ground into coarse powder, add 30 times of 70% alcohol refluxs of amount and extract 2 times, each 2h, filtering,
Ethanol is reclaimed, relative density is 1.34~1.40 thick paste when filtrate is concentrated into 50~60 DEG C;Ginseng is ground into coarse powder, with 6 times
Measure 80% alcohol reflux to extract 3 times, each 1h, filtering, merging filtrate, relative density when reclaiming ethanol and being concentrated into 50~60 DEG C
For 1.34~1.40 thick paste;Remaining cassia seed, oyster and subprostrate sophora are ground into coarse powder, add water to cook twice, and 1.5 is small every time
When, collecting decoction, filtration, filtrate concentrates 90~95 DEG C up to the clear cream that relative density is 1.14~1.16, is cooled to room temperature, plus 2
Amount ethanol, stirs again, places 48 hours, filtration, filtrate recycling ethanol, and relative density is when decoction is concentrated into 50~60 DEG C
1.34~1.40 thick paste;Merge above-mentioned thick paste, obtain drug extract mixture;Vacuum drying, crushed 80 mesh sieves, with 60%
Alcohol granulation, drying, whole grain, add the amount of being made 20% starch and 0.3% magnesium stearate element, tabletting, film coating,
Produce tablet.
Specification:Substrate weight 0.3g.
Usage and consumption:Orally, 4 tablets once, 3 times a day.
Embodiment 2
Prescription:Dye yam 308g, Fructus Sophorae 308g, cassia seed 308g, oyster (forging) 308g, ginseng 77g, subprostrate sophora 123g.
Technique:Take dye yam, the Fructus Sophorae to be ground into coarse powder, add 30 times of 70% alcohol refluxs of amount and extract 2 times, each 2h, filtering,
Ethanol is reclaimed, relative density is 1.34~1.40 thick paste when filtrate is concentrated into 50~60 DEG C;Ginseng is ground into coarse powder, with 6 times
Measure 80% alcohol reflux to extract 3 times, each 1h, filtering, merging filtrate, relative density when reclaiming ethanol and being concentrated into 50~60 DEG C
For 1.34~1.40 thick paste;Remaining cassia seed, oyster and subprostrate sophora are ground into coarse powder, add water to cook twice, and 1.5 is small every time
When, collecting decoction, filtration, filtrate concentrates 90~95 DEG C up to the clear cream that relative density is 1.14~1.16, is cooled to room temperature, plus 2
Amount ethanol, stirs again, places 48 hours, filtration, filtrate recycling ethanol, and relative density is when decoction is concentrated into 50~60 DEG C
1.34~1.40 thick paste;Merge above-mentioned thick paste, 60 DEG C dry, pulverize 80 mesh sieves, add the amount of being made 15% starch and
0.5% magnesium stearate, is mixed, and is loaded capsule, is produced capsule.
Specification:0.3g/.
Usage and consumption:Orally, every time 3,3 times a day.
Embodiment 3
Prescription:Dye yam 308g, Fructus Sophorae 308g, cassia seed 308g, oyster (forging) 308g, ginseng 77g, subprostrate sophora 123g.
Technique:Take dye yam, the Fructus Sophorae to be ground into coarse powder, add 30 times of 70% alcohol refluxs of amount and extract 2 times, each 2h, filtering,
Ethanol is reclaimed, relative density is 1.34~1.40 thick paste when filtrate is concentrated into 50~60 DEG C;Ginseng is ground into coarse powder, with 6 times
Measure 80% alcohol reflux to extract 3 times, each 1h, filtering, merging filtrate, relative density when reclaiming ethanol and being concentrated into 50~60 DEG C
For 1.34~1.40 thick paste;Remaining cassia seed, oyster and subprostrate sophora are ground into coarse powder, add water to cook twice, and 1.5 is small every time
When, collecting decoction, filtration, filtrate concentrates 90~95 DEG C up to the clear cream that relative density is 1.14~1.16, is cooled to room temperature, plus 2
Amount ethanol, stirs again, places 48 hours, filtration, filtrate recycling ethanol, and relative density is when decoction is concentrated into 50~60 DEG C
1.34~1.40 thick paste;Merge above-mentioned thick paste, add the dextrin of the amount of being made 60%, spray into 2% hydroxypropyl methyl cellulose second
Alcohol liquid 80ml pelletizes, packaging, produces granule.
Specification:Every bag of 10g.
Usage and consumption:Boiling water is taken after mixing it with water, one time 1 bag, 3 times a day.
Claims (4)
1. a kind of preparation method for the medicine for treating hemorrhoid, it is characterised in that:The medicine of the treatment hemorrhoid is according to composition by weight
Calculate, prepared by 308 parts of dye yam, 308 parts of the Fructus Sophorae, 308 parts of cassia seed, 308 parts of oyster of forging, 77 parts of ginseng, 123 parts of subprostrate sophora and
Into;The preparation method of the medicine is:Take dye yam, the Fructus Sophorae to be ground into coarse powder, add 30 times of 70% alcohol refluxs of amount and extract 2 times,
Ethanol is reclaimed in each 2h, filtering, and relative density is 1.34~1.40 thick paste when filtrate is concentrated into 50~60 DEG C;Ginseng is crushed
Into coarse powder, extracted 3 times with 6 times of 80% alcohol refluxs of amount, each 1h, filtering, merging filtrate, reclaim ethanol and be concentrated into 50~60
DEG C when relative density be 1.34~1.40 thick paste;Remaining cassia seed, oyster and subprostrate sophora are ground into coarse powder, add water to cook two
Secondary, 1.5 hours every time, collecting decoction, filtration, filtrate concentrated 90~95 DEG C up to the clear cream that relative density is 1.14~1.16,
It is cooled to room temperature, plus 2 times of amount ethanol, stirs, place 48 hours, filtration, filtrate recycling ethanol, decoction is concentrated into 50~60 DEG C
When relative density be 1.34~1.40 thick paste;Merge above-mentioned thick paste, add customary adjuvant and difference is conventionally made
Pharmaceutical preparation;The pharmaceutical preparation refers to tablet, granule, capsule, pill or oral liquid.
2. the preparation method of the medicine of hemorrhoid is treated as claimed in claim 1, it is characterised in that:The tablet is prepared:Take
Dye yam, the Fructus Sophorae are ground into coarse powder, add 30 times of 70% alcohol refluxs of amount and extract 2 times, ethanol is reclaimed in each 2h, filtering, and filtrate is dense
Relative density is 1.34~1.40 thick paste when being reduced to 50~60 DEG C;Ginseng is ground into coarse powder, is carried with 6 times of 80% alcohol refluxs of amount
Take 3 times, each 1h, filter, merging filtrate, reclaim ethanol and when being concentrated into 50~60 DEG C relative density for 1.34~1.40 it is thick
Cream;Remaining cassia seed, oyster and subprostrate sophora are ground into coarse powder, add water to cook twice, 1.5 hours every time, collecting decoction, filtration,
Filtrate concentrates 90~95 DEG C up to the clear cream that relative density is 1.14~1.16, is cooled to room temperature, plus 2 times of amount ethanol, and stirring is equal
It is even, place 48 hours, filtration, filtrate recycling ethanol, when decoction is concentrated into 50~60 DEG C relative density for 1.34~1.40 it is thick
Cream;Merge above-mentioned thick paste, be dried in vacuo, crushed 80 mesh sieves, with 60% alcohol granulation, drying, whole grain adds the amount of being made
20% starch and 0.3% magnesium stearate, tabletting, film coating, are produced.
3. the preparation method of the medicine of hemorrhoid is treated as claimed in claim 1, it is characterised in that:The capsule is prepared:
Take dye yam, the Fructus Sophorae to be ground into coarse powder, add 30 times of 70% alcohol refluxs of amount and extract 2 times, ethanol, filtrate are reclaimed in each 2h, filtering
Relative density is 1.34~1.40 thick paste when being concentrated into 50~60 DEG C;Ginseng is ground into coarse powder, with 6 times of 80% alcohol refluxs of amount
Extract 3 times, each 1h, filtering, merging filtrate, relative density is 1.34~1.40 when reclaiming ethanol and being concentrated into 50~60 DEG C
Thick paste;Remaining cassia seed, oyster and subprostrate sophora are ground into coarse powder, add water to cook twice, 1.5 hours every time, collecting decoction, filter
Cross, filtrate concentrates 90~95 DEG C up to the clear cream that relative density is 1.14~1.16, be cooled to room temperature, plus 2 times of amount ethanol, stirring is equal
It is even, place 48 hours, filtration, filtrate recycling ethanol, when decoction is concentrated into 50~60 DEG C relative density for 1.34~1.40 it is thick
Cream;Merge above-mentioned thick paste, 60 DEG C dry, pulverize 80 mesh sieves, add the starch and 0.5% magnesium stearate of the amount of being made 15%,
Mix, load capsule, produce.
4. the preparation method of the medicine of hemorrhoid is treated as claimed in claim 1, it is characterised in that:The granule is prepared:
Take dye yam, the Fructus Sophorae to be ground into coarse powder, add 30 times of 70% alcohol refluxs of amount and extract 2 times, ethanol, filtrate are reclaimed in each 2h, filtering
Relative density is 1.34~1.40 thick paste when being concentrated into 50~60 DEG C;Ginseng is ground into coarse powder, with 6 times of 80% alcohol refluxs of amount
Extract 3 times, each 1h, filtering, merging filtrate, relative density is 1.34~1.40 when reclaiming ethanol and being concentrated into 50~60 DEG C
Thick paste;Remaining cassia seed, oyster and subprostrate sophora are ground into coarse powder, add water to cook twice, 1.5 hours every time, collecting decoction, filter
Cross, filtrate concentrates 90~95 DEG C up to the clear cream that relative density is 1.14~1.16, be cooled to room temperature, plus 2 times of amount ethanol, stirring is equal
It is even, place 48 hours, filtration, filtrate recycling ethanol, when decoction is concentrated into 50~60 DEG C relative density for 1.34~1.40 it is thick
Cream;Merge above-mentioned thick paste, add the dextrin of the amount of being made 60%, spray into 2% hydroxypropyl methyl cellulose ethanol 80m1 granulations, bag
Dress, is produced;The parts by weight are g.
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Denomination of invention: Preparation method of drugs for treating hemorrhoids Effective date of registration: 20231106 Granted publication date: 20170822 Pledgee: Agricultural Bank of China Limited Guiyang Jiaxiu sub branch Pledgor: GUIZHOU RUNSHENG PHARMACY CO.,LTD. Registration number: Y2023520000063 |
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