CN104161791A - Traditional Chinese medicine composition for treating cervical and lumbar spondylosis as well as preparation method and application thereof - Google Patents
Traditional Chinese medicine composition for treating cervical and lumbar spondylosis as well as preparation method and application thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine composition for treating cervical and lumbar spondylosis as well as a preparation method and an application thereof. The traditional Chinese medicine composition is at least prepared from dalbergia odorifera vine, starntonia chinensis, valerian and flos puerariae. The invention further provides a preparation method for the traditional Chinese medicine composition and an application of the traditional Chinese medicine composition to preparing a drug for treating the cervical and lumbar spondylosis. Compared with the prior art, the traditional Chinese medicine composition has very remarkable effects in treating cervical and lumbar spondylosis, is not only high in efficiency, low in recurrence rate and free of toxic and side effects, but also simple in composition, low in preparation cost and easy to accept by a patient.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition for the treatment of cervical and lumbar diseases and its preparation method and application, belong to field of traditional Chinese.
Background technology
Limbs pain that cervical spondylosis and lumbal vertebra cause, numbness or unablely clinically much see, had a strong impact on routine work and life, causes very large misery to patient.
At present the treatment of cervical spondylosis and lumbar spondylosis is generally had to operative therapy, chemical medicine treatment and traditional Chinese medical science conservative treatment.Cervical and lumbar diseases treatment as employing operative therapy, inevitably there will be complication and sequela, brings larger misery to the later life of patient; Although chemotherapy curative effect is rapid, often, taking relief of symptoms as main, cures the symptoms, not the disease, and usually can follow a series of side reaction.And the effect that numerous doctor patients wish to reach by the conservative treatment of the traditional Chinese medical science recovery from illness.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine composition for the treatment of cervical and lumbar diseases and its preparation method and application.
For foregoing invention object, the invention provides following technical scheme:
The invention provides a kind of Chinese medicine composition for the treatment of cervical and lumbar diseases, it is at least made up of the raw material of following weight portion: 1～5 part, GUANGXIANG rattan, 1～5 part of Caulis et folium stauntoniae, 1～5 part of Rhizoma et radix valerianae, 1～5 part of Flos puerariae lobatae.
As preferably, the Chinese medicine composition of described treatment cervical and lumbar diseases is at least made up of the raw material of following weight portion: 1～2 part, GUANGXIANG rattan, 1～2 part of Caulis et folium stauntoniae, 1～2 part of Rhizoma et radix valerianae, 1～2 part of Flos puerariae lobatae.
As preferably, the Chinese medicine composition of described treatment cervical and lumbar diseases is at least made up of the raw material of following weight portion: 1 part, GUANGXIANG rattan, 1 part of Caulis et folium stauntoniae, 1 part of Rhizoma et radix valerianae, 5 parts of Flos puerariae lobataes.
As preferably, the Chinese medicine composition of described treatment cervical and lumbar diseases is at least made up of the raw material of following weight portion: 5 parts, GUANGXIANG rattan, 5 parts of Caulis et folium stauntoniaes, 5 parts of Rhizoma et radix valerianaes, 1 part of Flos puerariae lobatae.
The present invention also provides the preparation method of described treatment cervical and lumbar diseases Chinese medicine composition, mainly comprises the steps:
Take GUANGXIANG rattan, Caulis et folium stauntoniae, Rhizoma et radix valerianae and Flos puerariae lobatae, mix, soak, decoct, to obtain final product;
Or mainly comprise the steps:
(1) take GUANGXIANG rattan, Caulis et folium stauntoniae, Rhizoma et radix valerianae and Flos puerariae lobatae;
(2) Flos puerariae lobatae is extracted volatile oil, and volatile oil is for subsequent use; Mother solution after extraction volatile oil is for subsequent use; Flos puerariae lobatae medicinal residues after extraction volatile oil are for subsequent use;
(3) GUANGXIANG rattan, Rhizoma et radix valerianae and Caulis et folium stauntoniae mix with the Flos puerariae lobatae medicinal residues that extract after volatile oil in step (2), extracting in water, and the mother solution extracting in extracting solution and step (2) after volatile oil merges, and obtains total extracting solution; The volatile oil extracting in total extracting solution and step (2) is used in conjunction with as described treatment cervical and lumbar diseases Chinese medicine composition.
As preferably, the preparation method of described treatment cervical and lumbar diseases Chinese medicine composition mainly comprises the steps:
Take GUANGXIANG rattan, Caulis et folium stauntoniae, Rhizoma et radix valerianae and Flos puerariae lobatae, mix, add 8-12 times of water soaking 0.5-1.5h, decoct 1-3 time, each 1-2h, collecting decoction, to obtain final product;
Or mainly comprise the steps:
(1) take GUANGXIANG rattan, Caulis et folium stauntoniae, Rhizoma et radix valerianae and Flos puerariae lobatae;
(2) Flos puerariae lobatae is extracted volatile oil, and volatile oil is for subsequent use; Mother solution after extraction volatile oil is for subsequent use; GUANGXIANG rattan medicinal residues after extraction volatile oil are for subsequent use;
(3) Caulis et folium stauntoniae, Rhizoma et radix valerianae and GUANGXIANG rattan mix with the Flos puerariae lobatae medicinal residues that extract after volatile oil in step (2), add 8-14 times of volume water, under 50-100 DEG C of condition, extract 1-3 time, each 1-3 hour, merge extractive liquid,, the mother solution extracting in extracting solution and step (2) after volatile oil merges, and obtains total extracting solution; The volatile oil extracting in total extracting solution and step (2) is used in conjunction with as described treatment cervical and lumbar diseases Chinese medicine composition.
Preferred as another kind, described volatile oil can solidify or use cyclodextrin inclusion compound with porous silica.
The present invention finally also provides the application of above-mentioned Chinese medicine composition in preparation treatment cervical and lumbar diseases medicine.
As preferably, described Chinese medicine composition is made to oral formulations according to conventional formulation method.
Preferred further, described oral formulations is tablet, capsule, oral liquid, granule, powder, pill or drop pill.
Above-mentioned Chinese medicine composition of the present invention adds required various conventional adjuvant while preparing different dosage form, such as diluent, adhesive, disintegrating agent, fluidizer, lubricant, correctives, enclose material, adsorbing material etc. are prepared into any conventional oral formulations with conventional formulation method, for example, can be granule, powder, tablet, capsule, pill, oral liquid, drop pill etc.
Chinese medicine composition of the present invention derives from the clinical proved recipe " wide figured silk fabrics side " of the sincere hospital clinical treatment in Shen, Shanghai Pudong New Area cervical and lumbar diseases, the principles of formulating prescriptions are: taking GUANGXIANG rattan as monarch drug, blood circulation promoting and blood stasis dispelling and expelling wind and removing dampness, assistant is with Caulis et folium stauntoniae, Rhizoma et radix valerianae and Flos puerariae lobatae the kidney invigorating analgesia, channels sootheing and network vessel quickening and softening hypertrophy, and all medicines share, make Liver and kidney be grown benefit, brain must be filled, and meridians are declared logical, and QI and blood is in harmonious proportion, wide figured silk fabrics side is that to effect a permanent cure be main thus, the compound Chinese medicinal preparation for the treatment of both the principal and secondary aspects of a disease.
Beneficial effect of the present invention is mainly:
Traditional Chinese medicine composition for treating cervical and lumbar diseases of the present invention has the effect of highly significant, and not only effective percentage is high, and relapse rate is low, have no side effect, and prescription is simple, and preparation cost is low, and patient is easy to accept.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in further detail, but should notice that scope of the present invention is not subject to any restriction of these examples.
Embodiment 1
GUANGXIANG rattan 4g, Caulis et folium stauntoniae 4g, Rhizoma et radix valerianae 4g, Flos puerariae lobatae 20g
Above-mentioned medical material is added to 10 times of water gagings and soak 1 hour, decoct 2 times, each 1 hour, collecting decoction, to obtain final product.
Usage and consumption: every day potion.
Embodiment 2
GUANGXIANG rattan 10g, Caulis et folium stauntoniae 10g, Rhizoma et radix valerianae 10g, Flos puerariae lobatae 2g
Above-mentioned medical material is added to 8 times of water gagings and soak 0.5 hour, decoct 3 times, each 1.5 hours, collecting decoction, to obtain final product.
Usage and consumption: every day potion.
Embodiment 3
GUANGXIANG rattan 900g, Caulis et folium stauntoniae 900g, Rhizoma et radix valerianae 900g, Flos puerariae lobatae 900g
Flos puerariae lobatae is extracted volatile oil, and volatile oil is for subsequent use, and the mother solution after extraction volatile oil is for subsequent use, and the medicinal residues after extraction volatile oil are for subsequent use; Medicinal residues after GUANGXIANG rattan, Caulis et folium stauntoniae, Rhizoma et radix valerianae are extracted volatile oil with Flos puerariae lobatae mix, and add 10 times of volume water, under 100 DEG C of conditions, extract 2 times, each 2 hours, merge extractive liquid,, the mother solution that extracting solution and GUANGXIANG rattan are extracted after volatile oil merges, centrifugal filtration, filtrate is condensed into thick paste, and thick paste is mixed with dextrin, granulation, dry, spray into volatile oil, mix homogeneously, incapsulate, obtain 400, obtain capsule.
Embodiment 4
GUANGXIANG rattan 15g, Caulis et folium stauntoniae 3g, Rhizoma et radix valerianae 6g, Flos puerariae lobatae 6g
Above-mentioned medical material is added to 12 times of water gagings and soak 1.5 hours, decoct 1 time, each 2 hours, collecting decoction, to obtain final product.
Usage and consumption: every day potion.
Embodiment 5
GUANGXIANG rattan 600g, Caulis et folium stauntoniae 600g, Rhizoma et radix valerianae 3000g, Flos puerariae lobatae 3000g
Flos puerariae lobatae is extracted volatile oil, and volatile oil solidifies with porous silica, and the mother solution after extraction volatile oil is for subsequent use, and the medicinal residues after extraction volatile oil are for subsequent use; Medicinal residues after GUANGXIANG rattan, Caulis et folium stauntoniae, Rhizoma et radix valerianae are extracted volatile oil with Flos puerariae lobatae mix, and add 8 times of volume water, under 50 DEG C of conditions, extract 3 times, each 3 hours, merge extractive liquid,, the mother solution that extracting solution and Flos puerariae lobatae are extracted after volatile oil merges, centrifugal filtration, filtrate is condensed into thick paste, thick paste is mixed to granulation with dextrin, dry, curing with porous silica granule volatile oil, Pulvis Talci, magnesium stearate are mixed homogeneously, and tabletting, obtains tablet.
Embodiment 6
GUANGXIANG rattan 10g, Caulis et folium stauntoniae 5g, Rhizoma et radix valerianae 5g, Flos puerariae lobatae 5g
Flos puerariae lobatae is extracted volatile oil, and volatile oil is for subsequent use, and the mother solution after extraction volatile oil is for subsequent use, and the medicinal residues after extraction volatile oil are for subsequent use; Medicinal residues after GUANGXIANG rattan, Caulis et folium stauntoniae, Rhizoma et radix valerianae are extracted volatile oil with Flos puerariae lobatae mix, add 14 times of volume water, under 80 DEG C of conditions, extract 1 time, each 3 hours, merge extractive liquid,, the mother solution that extracting solution and Flos puerariae lobatae are extracted after volatile oil merges, centrifugal filtration, filtrate is condensed into thick paste, mixs homogeneously with the Macrogol 4000 of volatile oil, thawing, dripping becomes drop pill, obtains drop pill.
Embodiment 7
GUANGXIANG rattan 10g, Caulis et folium stauntoniae 5g, Rhizoma et radix valerianae 10g, Flos puerariae lobatae 10g
Flos puerariae lobatae is extracted volatile oil, and volatile oil is for subsequent use, and the mother solution after extraction volatile oil is for subsequent use, and the medicinal residues after extraction volatile oil are for subsequent use; Medicinal residues after GUANGXIANG rattan, Caulis et folium stauntoniae, Rhizoma et radix valerianae are extracted volatile oil with Flos puerariae lobatae mix, and add 10 times of volume water, under 70 DEG C of conditions, extract 2 times, each 3 hours, merge extractive liquid,, the mother solution that extracting solution and Flos puerariae lobatae are extracted after volatile oil merges, centrifugal filtration, concentrated, add ethanol to ethanol content and reach 60%, precipitate with ethanol 48 hours, gets supernatant and reclaims ethanol, adds volatile oil and suitable quantity of water, activated carbon decolorizing, filters, and divides and is filled in oral liquid bottle, sterilizing, obtains oral liquid.
Embodiment 8
GUANGXIANG rattan 10g, Caulis et folium stauntoniae 5g, Rhizoma et radix valerianae 10g, Flos puerariae lobatae 10g
Flos puerariae lobatae is extracted volatile oil, volatile oil HP-β-CD enclose, and the mother solution after extraction volatile oil is for subsequent use, and the medicinal residues after extraction volatile oil are for subsequent use; Medicinal residues after GUANGXIANG rattan, Caulis et folium stauntoniae, Rhizoma et radix valerianae are extracted volatile oil with Flos puerariae lobatae mix, add 12 times of volume water, under 90 DEG C of conditions, extract 3 times, each 1 hour, merge extractive liquid,, the mother solution that extracting solution and Flos puerariae lobatae are extracted after volatile oil merges, and centrifugal filtration is concentrated, add ethanol to ethanol content and reach 60%, precipitate with ethanol 48 hours, gets supernatant and reclaims ethanol, adds suitable quantity of water, activated carbon decolorizing, filter, add the volatile oil of HP-β-CD enclose, adjust volume and pH, filter, divide and be filled in oral liquid bottle, sterilizing, obtains oral liquid.
Embodiment 9
GUANGXIANG rattan 90g, Caulis et folium stauntoniae 60g, Rhizoma et radix valerianae 90g, Flos puerariae lobatae 90g
Flos puerariae lobatae is extracted volatile oil, volatile oil HP-β-CD enclose, and the mother solution after extraction volatile oil is for subsequent use, and the medicinal residues after extraction volatile oil are for subsequent use; Medicinal residues after GUANGXIANG rattan, Caulis et folium stauntoniae, Rhizoma et radix valerianae are extracted volatile oil with Flos puerariae lobatae mix, and add 12 times of volume water, under 100 DEG C of conditions, extract 2 times, each 2 hours, merge extractive liquid,, the mother solution that extracting solution and Flos puerariae lobatae are extracted after volatile oil merges, centrifugal filtration, filtrate is condensed into thick paste, thick paste is mixed to granulation with the volatile oil of HP-β-CD enclose, appropriate dextrin and Icing Sugar, dry, make granule 100g, be distributed into 10 bags, every bag 10g.
Usage and consumption: oral, a 10g, 2 times on the one, warm boiled water.
Embodiment 10 clinical drug therapeutic effect of the present invention
(1) physical data
Shanghai Pudong New Area Shen Cheng hospital cervical spondylosis, lumbar spondylosis patient 720 examples, be divided into three treatment groups and a matched group at random, every group of 180 people for the treatment of group, totally 540 people, Patients with Cervical Spondylopathy 273 examples, lumbar spondylosis patient 267 examples, 52.6 years old mean age; Matched group 180 people, Patients with Cervical Spondylopathy 91 examples, lumbar spondylosis patient 89 examples, 53.2 years old mean age.Two groups of sexes, age, the course of disease etc. are learned and are processed by statistics, and no significant difference (P>O.05), has comparability.
(2) Therapeutic Method
1. matched group gives capsules for curing waist pain (Guangzhou Baiyunshan Zhongyi Pharmaceutical Co., Ltd.), use by package insert, and within 30 days, be 1 course for the treatment of.
2. treatment group is divided into 1 group for the treatment of, 2 groups of treatments and treats 3 groups, gives respectively 1, the 3 and 9 prepared Chinese medicine compositions of the present invention by embodiment.
Usage and consumption: treating 1 group of dosage is (GUANGXIANG rattan 4g, Caulis et folium stauntoniae 4g, Rhizoma et radix valerianae 4g, Flos puerariae lobatae 20g), every day potion; Treat 2 groups of oral capsules, each 4, twice of every day; Treat 3 groups of oral granular formulations, a 10g, warm boiled water, 2 times on the one continuous 30 days is a course for the treatment of.
(3) therapeutic outcome
In all cases, 3 courses for the treatment of of mean treatment.Therapeutic outcome is in table 1, the compare total effective rate 62.8% of matched group, the total effective rate of three treatment groups is respectively 95.0%, 96.1% and 95.6%, all significantly raise, difference has statistical significance (P<0.01), shows that Chinese medicine composition of the present invention is obviously better than matched group for cervical and lumbar diseases curative effect;
The compare relapse rate 46.1% of matched group, the relapse rate of three treatment groups is respectively 7.2%, 5.6% and 6.1%, all significantly reduce, difference has statistical significance (P<0.01), show compared with matched group, Chinese medicine composition of the present invention can significantly reduce cervical and lumbar diseases relapse rate.
And during treatment, untoward reaction 20 examples appear in matched group, and all patients for the treatment of group are showed no obvious adverse reaction, show that we's treatment cervical and lumbar diseases is safe and effective.
Table 1 Chinese medicine composition totall effective rate in clinical treatment of the present invention and relapse rate result (%)
Note: compared with matched group, * P<0.01.
Claims (10)
1. a Chinese medicine composition for the treatment of cervical and lumbar diseases, is characterized in that: it is at least made up of the raw material of following weight portion: 1～5 part, GUANGXIANG rattan, 1～5 part of Caulis et folium stauntoniae, 1～5 part of Rhizoma et radix valerianae, 1～5 part of Flos puerariae lobatae.
2. the Chinese medicine composition for the treatment of according to claim 1 cervical and lumbar diseases, is characterized in that: it is at least made up of the raw material of following weight portion: 1～2 part, GUANGXIANG rattan, 1～2 part of Caulis et folium stauntoniae, 1～2 part of Rhizoma et radix valerianae, 1～2 part of Flos puerariae lobatae.
3. the Chinese medicine composition for the treatment of according to claim 1 cervical and lumbar diseases, is characterized in that: it is at least made up of the raw material of following weight portion: 1 part, GUANGXIANG rattan, 1 part of Caulis et folium stauntoniae, 1 part of Rhizoma et radix valerianae, 5 parts of Flos puerariae lobataes.
4. the Chinese medicine composition for the treatment of according to claim 1 cervical and lumbar diseases, is characterized in that: it is at least made up of the raw material of following weight portion: 5 parts, GUANGXIANG rattan, 5 parts of Caulis et folium stauntoniaes, 5 parts of Rhizoma et radix valerianaes, 1 part of Flos puerariae lobatae.
5. the preparation method for the treatment of cervical and lumbar diseases Chinese medicine composition described in claim 1-4 any one, is characterized in that: mainly comprise the steps:
Take GUANGXIANG rattan, Caulis et folium stauntoniae, Rhizoma et radix valerianae and Flos puerariae lobatae, mix, soak, decoct, to obtain final product;
Or mainly comprise the steps:
(1) take GUANGXIANG rattan, Caulis et folium stauntoniae, Rhizoma et radix valerianae and Flos puerariae lobatae;
(2) Flos puerariae lobatae is extracted volatile oil, and volatile oil is for subsequent use; Mother solution after extraction volatile oil is for subsequent use; Flos puerariae lobatae medicinal residues after extraction volatile oil are for subsequent use;
(3) GUANGXIANG rattan, Rhizoma et radix valerianae and Caulis et folium stauntoniae mix with the Flos puerariae lobatae medicinal residues that extract after volatile oil in step (2), extracting in water, and the mother solution extracting in extracting solution and step (2) after volatile oil merges, and obtains total extracting solution; The volatile oil extracting in total extracting solution and step (2) is used in conjunction with as described treatment cervical and lumbar diseases Chinese medicine composition.
6. the preparation method for the treatment of cervical and lumbar diseases Chinese medicine composition according to claim 5, is characterized in that:
Take GUANGXIANG rattan, Caulis et folium stauntoniae, Rhizoma et radix valerianae and Flos puerariae lobatae, mix, add 8-12 times of water soaking 0.5-1.5h, decoct 1-3 time, each 1-2h, collecting decoction, to obtain final product;
Or mainly comprise the steps:
(1) take GUANGXIANG rattan, Caulis et folium stauntoniae, Rhizoma et radix valerianae and Flos puerariae lobatae;
(2) Flos puerariae lobatae is extracted volatile oil, and volatile oil is for subsequent use; Mother solution after extraction volatile oil is for subsequent use; GUANGXIANG rattan medicinal residues after extraction volatile oil are for subsequent use;
(3) Caulis et folium stauntoniae, Rhizoma et radix valerianae and GUANGXIANG rattan mix with the Flos puerariae lobatae medicinal residues that extract after volatile oil in step (2), add 8-14 times of volume water, under 50-100 DEG C of condition, extract 1-3 time, each 1-3 hour, merge extractive liquid,, the mother solution extracting in extracting solution and step (2) after volatile oil merges, and obtains total extracting solution; The volatile oil extracting in total extracting solution and step (2) is used in conjunction with as described treatment cervical and lumbar diseases Chinese medicine composition.
7. the preparation method for the treatment of cervical and lumbar diseases Chinese medicine composition according to claim 5, is characterized in that: described volatile oil can solidify or use cyclodextrin inclusion compound with porous silica.
8. the application of Chinese medicine composition in preparation treatment cervical and lumbar diseases medicine described in claim 1-4 any one.
9. application as claimed in claim 8, is characterized in that: described Chinese medicine composition is made to oral formulations according to conventional formulation method.
10. application as claimed in claim 9, is characterized in that: described oral formulations is tablet, capsule, oral liquid, granule, powder, pill or drop pill.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106266260A (en) * | 2016-09-27 | 2017-01-04 | 成都市飞龙水处理技术研究所 | A kind of pill medicine treating cervical and lumbar diseases and preparation method thereof |
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| CN102526607A (en) * | 2010-12-25 | 2012-07-04 | 冷刚 | Medicine for treating lumbar intervertebral disc herniation |
| CN103550540A (en) * | 2013-11-15 | 2014-02-05 | 王国强 | Pharmaceutical composition for preventing and treating cervical spondylosis and lumbar spondylosis |
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Patent Citations (2)
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| CN102526607A (en) * | 2010-12-25 | 2012-07-04 | 冷刚 | Medicine for treating lumbar intervertebral disc herniation |
| CN103550540A (en) * | 2013-11-15 | 2014-02-05 | 王国强 | Pharmaceutical composition for preventing and treating cervical spondylosis and lumbar spondylosis |
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| 南京中医药大学编著: "《中药大辞典.第2版（修订本）》", 30 June 2014, 上海科学技术出版社 * |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106266260A (en) * | 2016-09-27 | 2017-01-04 | 成都市飞龙水处理技术研究所 | A kind of pill medicine treating cervical and lumbar diseases and preparation method thereof |
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