CN104161791B - It is a kind of to treat Chinese medicine composition of cervical and lumbar diseases and its preparation method and application - Google Patents
It is a kind of to treat Chinese medicine composition of cervical and lumbar diseases and its preparation method and application Download PDFInfo
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Abstract
The invention provides a kind of Chinese medicine composition for treating cervical and lumbar diseases and its preparation method and application.The Chinese medicine composition is at least as made by wide fragrant rattan, stauntonvine, valerian and flower of kudzuvine.Present invention also offers the preparation method of the Chinese medicine composition, and its application in treatment cervical and lumbar diseases medicine is prepared.Compared with prior art, traditional Chinese medicine composition for treating cervical and lumbar diseases of the present invention have the effect of highly significant, and not only efficient high, recurrence rate is low, has no toxic side effect, and prescription is simple, and preparation cost is low, and patient is easy to receive.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition for treating cervical and lumbar diseases and its preparation method and application, belong to Chinese medicine preparation
Field.
Background technology
Limbs pain, numb or powerless clinic are much shown in caused by cervical spondylopathy and lumbal vertebra, have had a strong impact on daily work
Make and live, very big pain is caused to patient.
The treatment to cervical spondylopathy and lumbar vertebra disease typically has operative treatment, chemical drug treatment and traditional Chinese medical science conservative treatment at present.Neck waist
Vertebra disease treatment such as uses operative treatment, then complication and sequelae inevitably occurs, the life later to patient is brought
Bigger pain；Although chemotherapy curative effect is rapid, often based on relief of symptoms, cure the symptoms, not the disease, Er Qiechang
Often can be with a series of side reaction.And numerous doctor patients are intended to reach the effect of recovery from illness by the conservative treatment of the traditional Chinese medical science.
The content of the invention
It is an object of the invention to provide a kind of Chinese medicine composition for treating cervical and lumbar diseases and its preparation method and application.
For foregoing invention purpose, the present invention provides following technical scheme：
The invention provides a kind of Chinese medicine composition for treating cervical and lumbar diseases, it is at least by the raw material system of following parts by weight
Into：Wide 1~5 part of rattan of perfume, 1~5 part of stauntonvine, 1~5 part of valerian, 1~5 part of flower of kudzuvine.
Preferably, the Chinese medicine composition of the treatment cervical and lumbar diseases is at least made up of the raw material of following parts by weight：It is wide fragrant
1~2 part of rattan, 1~2 part of stauntonvine, 1~2 part of valerian, 1~2 part of flower of kudzuvine.
Preferably, the Chinese medicine composition of the treatment cervical and lumbar diseases is at least made up of the raw material of following parts by weight：It is wide fragrant
1 part of rattan, 1 part of stauntonvine, 1 part of valerian, 5 parts of flower of kudzuvine.
Preferably, the Chinese medicine composition of the treatment cervical and lumbar diseases is at least made up of the raw material of following parts by weight：It is wide fragrant
5 parts of rattan, 5 parts of stauntonvine, 5 parts of valerian, 1 part of flower of kudzuvine.
Present invention also offers the preparation method of the treatment cervical and lumbar diseases Chinese medicine composition, mainly comprise the following steps：
Wide fragrant rattan, stauntonvine, valerian and flower of kudzuvine, mixing are weighed, is soaked, is decocted, produce；
Or mainly comprise the following steps：
(1) wide fragrant rattan, stauntonvine, valerian and flower of kudzuvine are weighed；
(2) flower of kudzuvine extracts volatile oil, and volatile oil is standby；The mother liquor extracted after volatile oil is standby；Extract the Pueraria lobota after volatile oil
Flower pesticide slag is standby；
(3) wide fragrant rattan, valerian and stauntonvine mix with extracting the flower of kudzuvine dregs of a decoction after volatile oil in step (2), extracting in water,
Extract solution merges with extracting the mother liquor after volatile oil in step (2), obtains total extract solution；Total extract solution and extraction in step (2)
Volatile oil is used cooperatively as the treatment cervical and lumbar diseases Chinese medicine composition.
Preferably, the preparation method of the treatment cervical and lumbar diseases Chinese medicine composition mainly comprises the following steps：
Wide fragrant rattan, stauntonvine, valerian and flower of kudzuvine are weighed, is mixed, plus 8-12 times of water immersion 0.5-1.5h, decoction 1-3 times, often
Secondary 1-2h, collecting decoction is produced；
Or mainly comprise the following steps：
(1) wide fragrant rattan, stauntonvine, valerian and flower of kudzuvine are weighed；
(2) flower of kudzuvine extracts volatile oil, and volatile oil is standby；The mother liquor extracted after volatile oil is standby；Extract wide after volatile oil
The fragrant rattan dregs of a decoction are standby；
(3) stauntonvine, valerian and wide fragrant rattan mix with extracting the flower of kudzuvine dregs of a decoction after volatile oil in step (2), plus 8-14 times
Volume of water, is extracted 1-3 time under the conditions of 50-100 DEG C, each 1-3 hour, merges extract solution, and extract solution is waved with the middle extraction of step (2)
Mother liquor after hair oil merges, and obtains total extract solution；Total extract solution is used cooperatively with the volatile oil extracted in step (2) and controlled described in
Treat cervical and lumbar diseases Chinese medicine composition.
As it is another preferably, the volatile oil can be solidified or with cyclodextrin encapsulated with porous silica.
The present invention finally additionally provides application of the above-mentioned Chinese medicine composition in treatment cervical and lumbar diseases medicine is prepared.
Preferably, the Chinese medicine composition is made into oral formulations according to conventional formulation method.
Further preferably, the oral formulations are tablet, capsule, oral liquid, granule, powder, pill or dripping pill
Agent.
The above-mentioned Chinese medicine composition of the present invention adds required various customary adjuvants when preparing different dosage forms, for example, dilute
Agent, binder, disintegrant, glidant, lubricant, flavouring, inclusion material, sorbing material etc. are prepared with conventional formulation method
Into the oral formulations that any one is conventional, for example, can be granule, powder, tablet, capsule, pill, oral liquid, pill
Deng.
The Chinese medicine composition of the present invention is tested from the clinic of the sincere hospital clinical treatment cervical and lumbar diseases in Shanghai Pudong New Area Shen
Side " wide figured silk fabrics side ", the principles of formulating prescriptions are：Using wide fragrant rattan as monarch drug in a prescription, promoting blood circulation and removing blood stasis and dispelling wind and eliminating dampness is helped with stauntonvine, valerian and flower of kudzuvine
Kidney tonifying analgesia, channels sootheing and network vessel quickening and softening hyperplasia, all medicines are shared, and liver kidney is grown benefit, brain must fill, and channels and collaterals are able to declare logical, gas
Blood is reconciled, and thus wide figured silk fabrics side is the compound Chinese medicinal preparation treated both principal and secondary aspect of disease based on effecting a permanent cure.
Beneficial effects of the present invention are mainly：
The traditional Chinese medicine composition for treating cervical and lumbar diseases of the present invention have the effect of highly significant, not only efficient high, recurrence rate
It is low, have no toxic side effect, and also prescription is simple, and preparation cost is low, and patient is easy to receive.
Embodiment
With reference to embodiment, the present invention is described in further detail, but should be noted that the scope of the present invention not by this
Any limitation of a little examples.
Embodiment 1
Wide perfume rattan 4g, stauntonvine 4g, valerian 4g, flower of kudzuvine 20g
Add 10 times of amount water to soak 1 hour above-mentioned medicinal material, decoct 2 times, 1 hour every time, collecting decoction was produced.
Usage and consumption：One portion per day.
Embodiment 2
Wide perfume rattan 10g, stauntonvine 10g, valerian 10g, flower of kudzuvine 2g
Add 8 times of amount water to soak 0.5 hour above-mentioned medicinal material, decoct 3 times, 1.5 hours every time, collecting decoction was produced.
Usage and consumption：One portion per day.
Embodiment 3
Wide perfume rattan 900g, stauntonvine 900g, valerian 900g, flower of kudzuvine 900g
Flower of kudzuvine extracts volatile oil, and volatile oil is standby, and the mother liquor extracted after volatile oil is standby, and the dregs of a decoction extracted after volatile oil are standby
With；The dregs of a decoction that wide perfume rattan, stauntonvine, valerian are extracted after volatile oil with flower of kudzuvine are mixed, plus 10 times of volume of water, are carried under the conditions of 100 DEG C
Take 2 times, 2 hours every time, merge extract solution, the mother liquor that extract solution is extracted after volatile oil with wide fragrant rattan merges, centrifugal filtration, filtrate
Thick paste is condensed into, thick paste is mixed with dextrin, particle is made, is dried, volatile oil is sprayed into, is well mixed, loads capsule, obtains 400
Grain, produces capsule.
Embodiment 4
Wide perfume rattan 15g, stauntonvine 3g, valerian 6g, flower of kudzuvine 6g
Add 12 times of amount water to soak 1.5 hours above-mentioned medicinal material, decoct 1 time, 2 hours every time, collecting decoction was produced.
Usage and consumption：One portion per day.
Embodiment 5
Wide perfume rattan 600g, stauntonvine 600g, valerian 3000g, flower of kudzuvine 3000g
Flower of kudzuvine extracts volatile oil, and volatile oil is solidified with porous silica, and the mother liquor extracted after volatile oil is standby, and extraction is waved
The dregs of a decoction after hair oil are standby；The dregs of a decoction that wide perfume rattan, stauntonvine, valerian are extracted after volatile oil with flower of kudzuvine are mixed, plus 8 times of volume of water,
Extracted under the conditions of 50 DEG C 3 times, 3 hours every time, merge extract solution, the mother liquor that extract solution is extracted after volatile oil with flower of kudzuvine merges, from
The heart is filtered, and filtrate is condensed into thick paste, thick paste is mixed with dextrin, and particle is made, and dries, particle is consolidated with porous silica
Volatile oil, talcum powder, the magnesium stearate of change are well mixed, and tabletting produces tablet.
Embodiment 6
Wide perfume rattan 10g, stauntonvine 5g, valerian 5g, flower of kudzuvine 5g
Flower of kudzuvine extracts volatile oil, and volatile oil is standby, and the mother liquor extracted after volatile oil is standby, and the dregs of a decoction extracted after volatile oil are standby
With；The dregs of a decoction that wide perfume rattan, stauntonvine, valerian are extracted after volatile oil with flower of kudzuvine are mixed, plus 14 times of volume of water, are extracted under the conditions of 80 DEG C
1 time, 3 hours every time, merge extract solution, the mother liquor that extract solution is extracted after volatile oil with flower of kudzuvine merges, centrifugal filtration, filtrate concentration
Into thick paste, it is well mixed with volatile oil, the Macrogol 4000 melted, dripping pill is made in drop, produces pill.
Embodiment 7
Wide perfume rattan 10g, stauntonvine 5g, valerian 10g, flower of kudzuvine 10g
Flower of kudzuvine extracts volatile oil, and volatile oil is standby, and the mother liquor extracted after volatile oil is standby, and the dregs of a decoction extracted after volatile oil are standby
With；The dregs of a decoction that wide perfume rattan, stauntonvine, valerian are extracted after volatile oil with flower of kudzuvine are mixed, plus 10 times of volume of water, are extracted under the conditions of 70 DEG C
2 times, 3 hours every time, merge extract solution, the mother liquor that extract solution is extracted after volatile oil with flower of kudzuvine merges, centrifugal filtration, concentration, plus
Ethanol to ethanol content reaches 60%, and alcohol precipitation 48 hours takes supernatant to reclaim ethanol, adds volatile oil and suitable quantity of water, activated carbon
Decolourize, filtering is dispensed into oral liquid bottle, sterilizing produces oral liquid.
Embodiment 8
Wide perfume rattan 10g, stauntonvine 5g, valerian 10g, flower of kudzuvine 10g
Flower of kudzuvine extracts volatile oil, and volatile oil is included with hydroxypropyl-β-cyclodextrin, and the mother liquor extracted after volatile oil is standby, carries
Take the dregs of a decoction after volatile oil standby；The dregs of a decoction that wide perfume rattan, stauntonvine, valerian are extracted after volatile oil with flower of kudzuvine are mixed, plus 12 times of bodies
Ponding, extracts under the conditions of 90 DEG C 3 times, 1 hour every time, merges extract solution, extract solution extracts the mother liquor after volatile oil with flower of kudzuvine and closed
And, centrifugal filtration, concentration, plus ethanol to ethanol content reach 60%, and alcohol precipitation 48 hours takes supernatant to reclaim ethanol, add suitable
Water is measured, activated carbon decolorizing, filtering adds the volatile oil that hydroxypropyl-β-cyclodextrin is included, adjustment volume and pH, filtering, packing is extremely
In oral liquid bottle, sterilizing produces oral liquid.
Embodiment 9
Wide perfume rattan 90g, stauntonvine 60g, valerian 90g, flower of kudzuvine 90g
Flower of kudzuvine extracts volatile oil, and volatile oil is included with hydroxypropyl-β-cyclodextrin, and the mother liquor extracted after volatile oil is standby, carries
Take the dregs of a decoction after volatile oil standby；The dregs of a decoction that wide perfume rattan, stauntonvine, valerian are extracted after volatile oil with flower of kudzuvine are mixed, plus 12 times of bodies
Ponding, extracts under the conditions of 100 DEG C 2 times, 2 hours every time, merges extract solution, extract solution extracts the mother liquor after volatile oil with flower of kudzuvine and closed
And, centrifugal filtration, filtrate is condensed into thick paste, volatile oil, appropriate dextrin and the sugar that thick paste and hydroxypropyl-β-cyclodextrin are included
Powder is mixed, and particle is made, and is dried, that is, granule 100g is made, is distributed into 10 bags, often wraps 10g.
Usage and consumption：Orally, a 10g, 2 times a day, warm boiled water.
The clinical drug therapeutic effect of the present invention of embodiment 10
(1) general information
Shanghai Pudong New Area Shen Cheng hospitals cervical spondylopathy, lumbar vertebrae patient 720, are randomly divided into three treatment groups and one right
According to group, every group of 180 people for the treatment of group, totally 540 people, patient with cervical Spondylopathy 273, lumbar vertebrae patient 267, average age 52.6 years old；
The people of control group 180, patient with cervical Spondylopathy 91, lumbar vertebrae patient 89, average age 53.2 years old.Two groups of sexes, age, courses of disease etc.
It is statistically analyzed, no significant difference (P>O.05), with comparativity.
(2) treatment method
1. control group gives capsules for curing waist pain (Guangzhou Baiyunshan Zhongyi Pharmaceutical Co., Ltd.), is used by package insert,
It is within 30 days 1 course for the treatment of.
2. therapeutic component is 1 group for the treatment of, treats 2 groups and 3 groups for the treatment of, and the sheet as obtained by embodiment 1,3 and 9 is given respectively
Invention Chinese medicine composition.
Usage and consumption：It is (wide perfume rattan 4g, stauntonvine 4g, valerian 4g, flower of kudzuvine 20g), one portion per day to treat 1 group of dosage；
2 groups of oral capsules are treated, 4 every time, twice daily；Treat 3 groups of oral granular formulations, a 10g, warm boiled water, one day 2
It is secondary, it is within continuous 30 days a course for the treatment of.
(3) treatment results
In all cases, 3 courses for the treatment of of mean treatment.Treatment results are shown in Table 1, the total effective rate for the control group that compares
62.8%, the total effective rate of three treatment groups is respectively 95.0%, 96.1% and 95.6%, significantly rise, and difference has statistics
Learn meaning (P<0.01), show that Chinese medicine composition of the present invention is substantially better than control group for cervical and lumbar diseases curative effect；
Compare the recurrence rate 46.1% of control group, and the recurrence rate of three treatment groups is respectively 7.2%, 5.6% and
6.1%, significantly reduce, the statistically significant (P of difference<0.01), show compared with control group, Chinese medicine composition energy of the present invention
Enough significantly reduce cervical and lumbar diseases recurrence rate.
And during treatment, there is adverse reaction 20 in control group, and all patients for the treatment of group are showed no obvious adverse reaction, table
Bright we's treatment cervical and lumbar diseases are safe and effective.
The Chinese medicine composition totall effective rate in clinical treatment of the present invention of table 1 and recurrence rate result (%)
Note：Compared with control group, * P<0.01.
Claims (10)
1. a kind of Chinese medicine composition for treating cervical and lumbar diseases, it is characterised in that：It is made up of the raw material of following parts by weight：Wide perfume rattan
1~5 part, 1~5 part of stauntonvine, 1~5 part of valerian, 1~5 part of flower of kudzuvine；
The preparation method of the Chinese medicine composition mainly comprises the following steps：
Wide fragrant rattan, stauntonvine, valerian and flower of kudzuvine, mixing are weighed, is soaked, is decocted, produce；
Or mainly comprise the following steps：
(1) wide fragrant rattan, stauntonvine, valerian and flower of kudzuvine are weighed；
(2) flower of kudzuvine extracts volatile oil, and volatile oil is standby；The mother liquor extracted after volatile oil is standby；Extract the flower of kudzuvine medicine after volatile oil
Slag is standby；
(3) wide fragrant rattan, valerian and stauntonvine are mixed with extracting the flower of kudzuvine dregs of a decoction after volatile oil in step (2), and extracting in water is extracted
Liquid merges with extracting the mother liquor after volatile oil in step (2), obtains total extract solution；Total extract solution and the volatilization extracted in step (2)
Oil uses cooperatively the Chinese medicine composition as the treatment cervical and lumbar diseases.
2. the Chinese medicine composition of cervical and lumbar diseases is treated according to claim 1, it is characterised in that：Its by following parts by weight original
Material is made：Wide 1~2 part of rattan of perfume, 1~2 part of stauntonvine, 1~2 part of valerian, 1~2 part of flower of kudzuvine.
3. the Chinese medicine composition of cervical and lumbar diseases is treated according to claim 1, it is characterised in that：Its by following parts by weight original
Material is made：Wide 1 part of rattan of perfume, 1 part of stauntonvine, 1 part of valerian, 5 parts of flower of kudzuvine.
4. the Chinese medicine composition of cervical and lumbar diseases is treated according to claim 1, it is characterised in that：Its by following parts by weight original
Material is made：Wide 5 parts of rattan of perfume, 5 parts of stauntonvine, 5 parts of valerian, 1 part of flower of kudzuvine.
5. the preparation method of the Chinese medicine composition of any one of the claim 1-4 treatment cervical and lumbar diseases, it is characterised in that：Mainly
Comprise the following steps：
Wide fragrant rattan, stauntonvine, valerian and flower of kudzuvine, mixing are weighed, is soaked, is decocted, produce；
Or mainly comprise the following steps：
(1) wide fragrant rattan, stauntonvine, valerian and flower of kudzuvine are weighed；
(2) flower of kudzuvine extracts volatile oil, and volatile oil is standby；The mother liquor extracted after volatile oil is standby；Extract the flower of kudzuvine medicine after volatile oil
Slag is standby；
(3) wide fragrant rattan, valerian and stauntonvine are mixed with extracting the flower of kudzuvine dregs of a decoction after volatile oil in step (2), and extracting in water is extracted
Liquid merges with extracting the mother liquor after volatile oil in step (2), obtains total extract solution；Total extract solution and the volatilization extracted in step (2)
Oil uses cooperatively the Chinese medicine composition as the treatment cervical and lumbar diseases.
6. the preparation method of the Chinese medicine composition for the treatment of cervical and lumbar diseases according to claim 5, it is characterised in that：
Wide fragrant rattan, stauntonvine, valerian and flower of kudzuvine are weighed, is mixed, plus 8-12 times of water immersion 0.5-1.5h, decoction 1-3 times, every time
1-2h, collecting decoction is produced；
Or mainly comprise the following steps：
(1) wide fragrant rattan, stauntonvine, valerian and flower of kudzuvine are weighed；
(2) flower of kudzuvine extracts volatile oil, and volatile oil is standby；The mother liquor extracted after volatile oil is standby；Extract the wide fragrant rattan after volatile oil
The dregs of a decoction are standby；
(3) stauntonvine, valerian and wide fragrant rattan mix with extracting the flower of kudzuvine dregs of a decoction after volatile oil in step (2), plus 8-14 times of volume
Water, is extracted 1-3 time under the conditions of 50-100 DEG C, each 1-3 hour, merges extract solution, extract solution and the middle extraction volatile oil of step (2)
Mother liquor afterwards merges, and obtains total extract solution；Total extract solution uses cooperatively with the volatile oil extracted in step (2) and is used as the treatment neck
The Chinese medicine composition of lumbar vertebra disease.
7. the preparation method of the Chinese medicine composition for the treatment of cervical and lumbar diseases according to claim 5, it is characterised in that：It is described to wave
Hair oil is solidified with porous silica or with cyclodextrin encapsulated.
8. application of any one of the claim 1-4 Chinese medicine compositions in the medicine for preparing treatment cervical and lumbar diseases.
9. application as claimed in claim 8, it is characterised in that：Mouth is made according to conventional formulation method in the Chinese medicine composition
Formulation.
10. application as claimed in claim 9, it is characterised in that：The oral formulations are tablet, capsule, oral liquid, particle
Agent, powder, pill or pill.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410443067.2A CN104161791B (en) | 2014-09-02 | 2014-09-02 | It is a kind of to treat Chinese medicine composition of cervical and lumbar diseases and its preparation method and application |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410443067.2A CN104161791B (en) | 2014-09-02 | 2014-09-02 | It is a kind of to treat Chinese medicine composition of cervical and lumbar diseases and its preparation method and application |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104161791A CN104161791A (en) | 2014-11-26 |
| CN104161791B true CN104161791B (en) | 2017-09-12 |
Family
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| Application Number | Title | Priority Date | Filing Date |
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| CN201410443067.2A Expired - Fee Related CN104161791B (en) | 2014-09-02 | 2014-09-02 | It is a kind of to treat Chinese medicine composition of cervical and lumbar diseases and its preparation method and application |
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| CN (1) | CN104161791B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106266260A (en) * | 2016-09-27 | 2017-01-04 | 成都市飞龙水处理技术研究所 | A kind of pill medicine treating cervical and lumbar diseases and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102526607A (en) * | 2010-12-25 | 2012-07-04 | 冷刚 | Medicine for treating lumbar intervertebral disc herniation |
| CN103550540A (en) * | 2013-11-15 | 2014-02-05 | 王国强 | Pharmaceutical composition for preventing and treating cervical spondylosis and lumbar spondylosis |
-
2014
- 2014-09-02 CN CN201410443067.2A patent/CN104161791B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102526607A (en) * | 2010-12-25 | 2012-07-04 | 冷刚 | Medicine for treating lumbar intervertebral disc herniation |
| CN103550540A (en) * | 2013-11-15 | 2014-02-05 | 王国强 | Pharmaceutical composition for preventing and treating cervical spondylosis and lumbar spondylosis |
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| Publication number | Publication date |
|---|---|
| CN104161791A (en) | 2014-11-26 |
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