CN101690775A - Medicament having qi-supplementing, blood-nourishing, kidney-boosting, yang-reinforcing and anti-cancer effects - Google Patents
Medicament having qi-supplementing, blood-nourishing, kidney-boosting, yang-reinforcing and anti-cancer effects Download PDFInfo
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- CN101690775A CN101690775A CN200910158199A CN200910158199A CN101690775A CN 101690775 A CN101690775 A CN 101690775A CN 200910158199 A CN200910158199 A CN 200910158199A CN 200910158199 A CN200910158199 A CN 200910158199A CN 101690775 A CN101690775 A CN 101690775A
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Abstract
The invention belongs to the technical field of Chinese medicaments and particularly relates to a medicament having qi-supplementing, blood-nourishing, kidney-boosting, yang-reinforcing and anti-cancer effects. The medicament is characterized by comprising the following raw materials in percentage by mass: cordyceps sinensis 2-5, cornu cervi pantotrichum 0.5-2, ginseng 0.8-2.5 and other eight raw materials including raidx astragali, Chinese angelica, barbary wolfberry fruit, codonopsis pilosula, salvia miltiorrhiza bunge, rehmannia root, dwarf lilyturf tuber and Chinese magnoliavine fruit 8-18. To prepare the medicament, active ingredients of the cordyceps sinensis, the cornu cervi pantotrichum and ginseng are extracted by ethanol, the active ingredients of the other eight raw materials are extracted by water, the active ingredients are mixed and concentrated to make extractum, and the extractum is made into a medicament of a solid formulation or liquid formulation, or injection formulation or semifluid decocted extract. Clinical tests of and researches on the medicament prove that the medicament has remarkable effects of improving physical strength, improving memory and asthenic symptoms, delaying human body aging, boosting the kidney and reinforcing yang, and is free from toxic and side effects and safe in use.
Description
One, technical field:
The invention belongs to the Chinese medicine technical field, particularly a kind ofly have benefiting qi and nourishing blood, kidney tonifying is supporing yang and the medicine of antitumaous effect.
Two, technical background:
At present have benefiting qi and nourishing blood at tcm field, medicine that kidney tonifying is supporing yang is a lot, but they do not have anticancer effect, and the medicine with antitumaous effect does not possess benefiting qi and nourishing blood, effect that kidney tonifying is supporing yang.Show through existing medical research, the generation reason of cancer is mainly the gene mutation that human immune system's function reduction or other outside cause cause, on this serious illness of treatment cancer, there is not any specific drug at present, can only be to carry out medicinal health-care and prevention, perhaps eat cancer therapy drug and carry out auxiliary treatment, and the effect of these anticarcinogens varies, and can't estimate.
Three, summary of the invention:
The objective of the invention is to adopt outstanding Chinese tcm theory,, study and a kind ofly have benefiting qi and nourishing blood, the supporing yang function of kidney tonifying and have the body immunity of raising, anticancer effect medicine preferably again with the research means that traditional medicine and modern medicine combine.Prove through clinical experimental study, this medicine has tangible physical strength reinforcing, improve memory and deficient syndrome, delaying human body caducity, effect that kidney tonifying is supporing yang, has tangible eliminating pathogenic factor for supporting vital QI at this medicine of anticancer aspect, the effect of efficacy enhancing and toxicity reducing, the eliminating evil antineoplastic ability that is mainly reflected in, setting upright then is to strengthen to improve the human body immunity, and potentiation is that curative effect is obvious in the auxiliary treatment, and attenuation is embodied in liter, and upward effect is better in vain.In the toxicity clinical trial, also prove its no side effects fully, take safety.
Technical scheme is: thisly have benefiting qi and nourishing blood, kidney tonifying is supporing yang and the raw materials quality percentage ratio of the medicine of antitumaous effect is Cordyceps 2～5%, Cornu Cervi Pantotrichum 0.5～2%, Radix Ginseng 0.8～2.5%, the Radix Astragali 8～18%, Radix Angelicae Sinensis 8～18%, Fructus Lycii 8～18%, Radix Codonopsis 8～18%, Radix Salviae Miltiorrhizae 8～18%, Radix Rehmanniae 8～18%, Radix Ophiopogonis 8～18%, Fructus Schisandrae Chinensis 8～18%; Process recipes is: get Cordyceps, Cornu Cervi Pantotrichum, Radix Ginseng, 70～85% ethanol that add 7～9 times of medical material amounts, reflux, extract, 2～3 times, the each extraction 6～10 hours filtered, and merges backflow, reclaim ethanol, end when being concentrated into relative density and being 1.05～1.12 (room temperature mensuration), its extracting solution is extracting solution one, and is standby; Its medicinal residues and all the other eight flavor medical material waters decoct 2～4 times, each amount of water is 7～12 times of amounts of quality of medicinal material, each decocting time is 1～3 hour, collecting decoction, filter extracting solution two, extracting solution one merges with extracting solution one, and reconcentration to relative density is 1.25～1.35 extractum, at last this extractum is made solid dosage forms, liquid dosage form.The taking dose of this medicine is that 100 gram raw medicinal materials are an adult's 1～2 day consumption behind the feed proportioning.11 kinds of raw medicinal materials of the present invention are the clean medical material that can be used as medicine, and extracting solution one and extracting solution two are the active substance after extracting in the raw medicinal material, and the extractum of making is the semi-finished product of medicine for this reason, extractum is made be convenient to the dosage form that people take again.The present invention can be made into solid dosage medicine granule, hard capsule, soft capsule, drop pill, tablet, pill etc.; The liquid dosage form medicine has oral liquid, syrup; Also have injection and viscid soft extract in addition.The preparation method of solid dosage medicine, liquid dosage form medicine, injection type medicine, semifluid soft extracts drug form belongs to prior art, no longer here stating more.
Medicine of the present invention proves through clinical experimental study, it has tangible physical strength reinforcing, improve memory and deficient syndrome, delaying human body caducity, effect that kidney tonifying is supporing yang, the effect that has tangible eliminating pathogenic factor for supporting vital QI, efficacy enhancing and toxicity reducing at anticancer aspect, in the toxicity clinical trial, also prove its no side effects fully, take safety.
Four, the specific embodiment:
Embodiment 1:
Take by weighing raw material by following weight proportion:
Cordyceps 2kg Cornu Cervi Pantotrichum 2kg Radix Ginseng 0.8kg
Radix Astragali 8kg Radix Angelicae Sinensis 8kg Fructus Lycii 8kg
Radix Codonopsis 8kg Radix Salviae Miltiorrhizae 8kg Radix Rehmanniae 8kg
Radix Ophiopogonis 18kg Fructus Schisandrae Chinensis 13.2kg
Preparation method is as follows:
1, get 85% ethanol of Cordyceps, Cornu Cervi Pantotrichum, 7 times of medical material amounts of Radix Ginseng adding, reflux, extract, 3 times was extracted 6 hours at every turn, filtered, and medicinal residues are standby.Merge three times extracting solution, reclaim ethanol, is cooled to room temperature through concentrating, only, this extracting solution is extracting solution one, and is standby when surveying its relative density and be 1.05kg/ and rising;
2, above-mentioned medicinal residues and all the other eight flavor medical material waters decoct 2 times, and each amount of water is 12 times of amounts of medical material amount, decocted 1 hour at every turn, merge extractive liquid,, filter extracting solution two, standby;
3, merge extractive liquid, one and extracting solution two, being concentrated into relative density is the extractum that 1.25kg/ rises, drying, it is standby to get dry extract;
4, get dry extract, add carboxymethylstach sodium or starch and become micropowder or silica gel or microcrystalline Cellulose or Icing Sugar or dextrin an amount of, regulate total amount, the alcohol granulation with 60～85%, drying, granulate obtains granule; Above-mentioned extract powder or granule are made acceptable granule, hard capsule, soft capsule, drop pill, tablet, pill on the pharmaceutics.Preparation method is as follows in detail:
1, with above-mentioned granule packing, get granule, take 5 ~ 15g, every day 2 ~ 3 times at every turn.
2 or with above-mentioned extract powder filled capsules, make oral capsule (hard capsule, enteric coated capsule), take 2 ~ 4, every day 2 ~ 3 times at every turn.
3, above-mentioned dry extract is made suspension or pastel with suitable disperse medium, fully mixing is pressed into soft capsule, takes the 1--2 grain at every turn.Disperse medium multipurpose plant oil (as edible oil, Oleum Glycines, Semen arachidis hypogaeae wet goods), also available aqueous polyvinylidene or liquid paraffin etc.
4 or above-mentioned extractum is added in the suitable fusion substrate, mixing splashes in the not miscible condensed fluid, and condensation is shaped, and the flush away condensed fluid makes drop pill, takes 4 ~ 6 at every turn, every day 2 ~ 3 times.
5 or in above-mentioned granule, add lubricant, mixing, tabletting, coating (film-coat, enteric coating) makes tablet, takes 2 ~ 4 at every turn, every day 2 ~ 3 times.
6 or above-mentioned extract powder is added suitable adhesive make pill with adjuvant, packing is taken 3-10 at every turn and is restrained every day 2 ~ 3 times.
Embodiment 2:
Take by weighing raw material by following weight proportion:
Cordyceps 5kg Cornu Cervi Pantotrichum 0.5kg Radix Ginseng 2.5kg
Radix Astragali 18kg Radix Angelicae Sinensis 18kg 18kg Radix Ophiopogonis Radix Codonopsis 8kg
The Radix Salviae Miltiorrhizae 8kg Radix Rehmanniae 8kg 8kg Fructus Lycii 16kg that distinguishes the flavor of
Preparation method is as follows:
1, gets 70% ethanol of Cordyceps, Cornu Cervi Pantotrichum, 9 times of medical material amounts of Radix Ginseng adding, reflux, extract, 2 times, the each extraction 10 hours filtered, and medicinal residues are standby, merge extractive liquid,, reclaim ethanol, extracting solution is cooled to room temperature through concentrating, when surveying its relative density and be 1.12kg/ and rising only, this extracting solution is extracting solution one, and is standby;
2, above-mentioned medicinal residues and all the other eight flavor medical material waters decoct 4 times, and each amount of water is 7 times of amounts of medical material amount, decocted 3 hours at every turn, merge extractive liquid,, filter extracting solution two, standby;
3, extracting solution two merges with extracting solution one, is concentrated into relative density and is the extractum that 1.35kg/ rises, and is standby;
4, add other additive in the above-mentioned extractum, water is regulated total amount, makes acceptable oral liquid, syrup and soft extract on the pharmaceutics.Preparation method is as follows in detail:
1, in the above-mentioned extractum, add correctives acesulfame-K or cyclamate, citric acid, essence is an amount of, adds water and is modulated into total amount, mixing filters, and is distributed into every bottle of 10ml, sterilization promptly gets oral solutions.Take 1～2 bottle, every day 2 ~ 3 times at every turn.
2, add simple syrup in the above-mentioned extractum, make cane sugar content be not less than 45%, add an amount of preservative benzoic acid or sodium benzoate, essence, add water and regulate total amount, packing, sterilization makes syrup.Take 10～20 ml, every day 2 ~ 3 times at every turn.
3. the additional ingredients that extractum is added an amount of antiseptic, correctives and suit is brewed into certain density, receives cream, makes soft extract.Take 5 ~ 20g, every day 2 ~ 3 times at every turn.
Embodiment 3:
Take by weighing raw material by following weight proportion
Cordyceps 3kg Cornu Cervi Pantotrichum 1kg Radix Ginseng 1kg
Radix Astragali 8kg Radix Angelicae Sinensis 8kg Fructus Lycii 9kg Radix Codonopsis 18kg
Radix Salviae Miltiorrhizae 18kg Radix Rehmanniae 18kg 8kg Radix Ophiopogonis Fructus Schisandrae Chinensis 8kg
Preparation method is as follows:
1, gets 85% ethanol of Cordyceps, Cornu Cervi Pantotrichum, 7 times of medical material amounts of Radix Ginseng adding, reflux, extract, 3 times, the each extraction 6 hours filtered, and medicinal residues are standby, merge extractive liquid,, reclaim ethanol, extracting solution is cooled to room temperature through concentrating, when surveying its relative density and be 1.05kg/ and rising only, this extracting solution is extracting solution one, and is standby;
2, above-mentioned medicinal residues and all the other eight flavor medical material waters decoct 2 times, and each amount of water is 12 times of amounts of medical material amount, decocted 1 hour at every turn, merge extractive liquid,, filter extracting solution two, standby;
3, merge extractive liquid,, being concentrated into relative density is the extractum that 1.25kg/ rises, 8～12 times of distilled water that add the extractum quality are with the extractum stirring and dissolving, refinement treatment gets the injection extract, adds suitable additives such as chlorobutanol, sodium thiosulfate, sodium hydrogen phosphate, regulates total amount with water for injection, fine straining, sterilization, packing promptly gets injection.
Embodiment 4:
Take by weighing raw material by following weight proportion
Cordyceps 2kg Cornu Cervi Pantotrichum 0.6kg Radix Ginseng 0.9kg
Radix Astragali 8.5kg Radix Angelicae Sinensis 8.5kg Radix Codonopsis 8.5kg
Radix Salviae Miltiorrhizae 8.5kg Radix Rehmanniae 8.5kg 18kg Radix Ophiopogonis
Fructus Schisandrae Chinensis 18kg Fructus Lycii 18kg
Preparation method is as follows:
1, gets 70% ethanol of Cordyceps, Cornu Cervi Pantotrichum, 9 times of medical material amounts of Radix Ginseng adding, reflux, extract, 2 times, the each extraction 10 hours filtered, and medicinal residues are standby, merge extractive liquid,, reclaim ethanol, extracting solution is cooled to room temperature through concentrating, when surveying its relative density and be 1.12kg/ and rising only, this extracting solution is extracting solution one, and is standby;
2, above-mentioned medicinal residues and all the other eight flavor medical material waters decoct 4 times, and each amount of water is 7 times of amounts of medical material amount, decocted 3 hours at every turn, merge extractive liquid,, filter extracting solution two, standby;
3, extracting solution two merges with extracting solution one, and being concentrated into relative density is the extractum that 1.35kg/ rises, and drying gets dry extract, and is standby;
4, get dry extract, add carboxymethylstach sodium or starch and become micropowder or silica gel or microcrystalline Cellulose or Icing Sugar or dextrin an amount of, regulate total amount, the alcohol granulation with 60～85%, drying, granulate obtains granule; Above-mentioned extract powder or granule are made acceptable hard capsule, soft capsule, drop pill, granule, tablet, pill on the pharmaceutics.Preparation method is as follows in detail:
1, with above-mentioned extract powder filled capsules, make oral capsule (hard capsule, enteric coated capsule), take 2 ~ 4, every day 2 ~ 3 times at every turn.
2, above-mentioned dry extract is made suspension or pastel with suitable disperse medium, fully mixing is pressed into soft capsule, takes the 1--2 grain, every day 2 ~ 3 times at every turn.Disperse medium multipurpose plant oil (as edible oil, Oleum Glycines, Semen arachidis hypogaeae wet goods), also available aqueous polyvinylidene or liquid paraffin etc.
3 or above-mentioned extractum is added in the suitable fusion substrate, mixing splashes in the not miscible condensed fluid, and condensation is shaped, and the flush away condensed fluid makes drop pill, takes 4 ~ 8 at every turn, every day 2 ~ 3 times.
4, with above-mentioned granule packing, promptly get granule.Take 1 bag, every day 2 ~ 3 times at every turn.
5, above-mentioned granule is added suitable lubricant, mixing and additional ingredients, tabletting, coating (Film coated tablets, enteric coating).Take 1～2, every day 2 ~ 3 times at every turn.
6 or extract powder is added suitable adhesive make pill with adjuvant, packing is taken 3-10 at every turn and is restrained every day 2 ~ 3 times.
Claims (1)
- One kind have benefiting qi and nourishing blood, kidney tonifying is supporing yang and the medicine of antitumaous effect.The raw materials quality percentage ratio that it is characterized in that it is Cordyceps 2～5%, Cornu Cervi Pantotrichum 0.5～2%, Radix Ginseng 0.8～2.5%, the Radix Astragali 8～18%, Radix Angelicae Sinensis 8～18%, Fructus Lycii 8～18%, Radix Codonopsis 8～18%, Radix Salviae Miltiorrhizae 8～18%, Radix Rehmanniae 8～18%, Radix Ophiopogonis 8～18%, Fructus Schisandrae Chinensis 8～18%; Preparation method is to get 70～85% ethanol that Cordyceps, Cornu Cervi Pantotrichum, Radix Ginseng after the batching adds 7～9 times of medical material amounts, reflux, extract, 2～3 times, the each extraction 6～10 hours, filter, merge backflow, reclaim when ethanol to relative density is 1.05～1.12 (room temperature mensuration) and end, its extracting solution is extracting solution one, and is standby; Its medicinal residues and all the other eight flavor medical material waters decoct 2～4 times, each amount of water is 7～12 times of amounts of quality of medicinal material, the each decoction 1～3 hour, collecting decoction, filter extracting solution two, extracting solution one merges with extracting solution one, and reconcentration to relative density is 1.25～1.35 extractum, at last this extractum is made acceptable solid dosage forms granule, hard capsule, soft capsule, drop pill, tablet on the pharmaceutics; Or liquid dosage form oral liquid, syrup; Or injection type medicine; Or viscid soft extract.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910158199A CN101690775A (en) | 2009-07-15 | 2009-07-15 | Medicament having qi-supplementing, blood-nourishing, kidney-boosting, yang-reinforcing and anti-cancer effects |
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| Application Number | Priority Date | Filing Date | Title |
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| CN200910158199A CN101690775A (en) | 2009-07-15 | 2009-07-15 | Medicament having qi-supplementing, blood-nourishing, kidney-boosting, yang-reinforcing and anti-cancer effects |
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| CN101690775A true CN101690775A (en) | 2010-04-07 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102716320A (en) * | 2012-07-13 | 2012-10-10 | 杨献华 | Medicinal composition for treating non-small cell lung cancer |
| CN104147244A (en) * | 2014-08-27 | 2014-11-19 | 吉林省通化振国药业有限公司 | Ginseng and clematis chinensis oral liquid and preparation method thereof |
| CN105748902A (en) * | 2016-03-30 | 2016-07-13 | 中国人民解放军第五九医院 | Ginseng and antler essence boosting tablets and preparing method thereof |
| CN110812442A (en) * | 2019-12-06 | 2020-02-21 | 湖北威仕生物药业股份有限公司 | Preparation method and application of five-ginseng-astragalus oral solution |
-
2009
- 2009-07-15 CN CN200910158199A patent/CN101690775A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102716320A (en) * | 2012-07-13 | 2012-10-10 | 杨献华 | Medicinal composition for treating non-small cell lung cancer |
| CN102716320B (en) * | 2012-07-13 | 2013-09-11 | 杨献华 | Medicinal composition for treating non-small cell lung cancer |
| CN104147244A (en) * | 2014-08-27 | 2014-11-19 | 吉林省通化振国药业有限公司 | Ginseng and clematis chinensis oral liquid and preparation method thereof |
| CN105748902A (en) * | 2016-03-30 | 2016-07-13 | 中国人民解放军第五九医院 | Ginseng and antler essence boosting tablets and preparing method thereof |
| CN105748902B (en) * | 2016-03-30 | 2018-11-20 | 中国人民解放军第一五九医院 | Ginseng and pilose antler strengthening the essence piece and preparation method thereof |
| CN110812442A (en) * | 2019-12-06 | 2020-02-21 | 湖北威仕生物药业股份有限公司 | Preparation method and application of five-ginseng-astragalus oral solution |
| CN110812442B (en) * | 2019-12-06 | 2022-02-08 | 湖北威仕生物药业股份有限公司 | Preparation method and application of five-ginseng-astragalus oral solution |
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Open date: 20100407 |