CN101637565A - Pure Chinese medicinal preparation for treating arrhythmia - Google Patents

Abstract

The invention discloses a pure Chinese medicinal preparation for treating arrhythmia. The preparation consists of astragalus root, ginseng, dwarf lilyturf root, radix rehmanniae, kudzuvine root, golden thread, sophora, Chinese magnoliavine fruit, platycladi seeds, epimedium herb and radix glycyrrhizae preparata. The preparation can be prepared into granules, capsules, pills, capsules, tablets, mixture and the like by technical processing after active components of the medicament are extracted through a water decoction and ethanol precipitation process, and belongs to the Chinese medicinal preparation. The Chinese medicinal preparation has the functions of nourishing vital energy and blood, and dispersing blood stasis and dredging collateral, has simple and reasonable preparation process, remarkable curative effect, ensures sufficiency of vital energy and blood, and smoothness of heart vessels after administration, can treat disease of the arrhythmia, and has no toxic or side effect.

Description

A kind ofly be used for the treatment of ARR pure Chinese medicinal preparation

Technical field

The invention belongs to the Chinese medicine preparation technical field, be specifically related to a kind ofly be used for the treatment of ARR pure Chinese medicinal preparation, and its preparation method is furtherd investigate.

Technical background

Arrhythmia is clinical commonly encountered diseases, frequently-occurring disease, mainly is meant frequency, the rhythm and pace of moving things, origin position, conduction velocity and exciting order unusual of cardiac impulse.It belongs to categories such as Chinese medicine " cardiopalmus ", " thoracic obstruction ", adopts the Chinese medicine Coryza Treated by Syndrome Differentiation, and curative effect is preferably arranged.In secular clinical and experimentation, it is found that many Chinese medicines have antiarrhythmic effect, but not deep enough to its study on mechanism.The present invention is directed to its mechanism of action and done following research, and according to studied and defined should the side Chinese medicine form, the treatment arrhythmia is had significant curative effect.

The most course of disease of ARR patient is longer, and except that sense cardiopalmus, also common thirsty, the tired hyperhidrosis of body of breathing hard, vexed insomnia, arteries and veins come deficiency of both vital energy and Yin syndromes such as weakness is uneven.At internal organs weakness, functional disorder situation, adopt the method for treatment of supplementing QI and nourishing YIN, YIN and YANG balance regulating, to reach the multiple purpose of the arteries and veins of feeling at ease.The supplementing QI and nourishing YIN method not only can promote to adjust myocardial function, also is beneficial to the overall health of patients of improving the patient simultaneously.As adopting prescriptions such as Radix Codonopsis, Radix Ophiopogonis, Fructus Schisandrae Chinensis, Radix Pseudostellariae, Rhizoma Polygonati Odorati, Bulbus Lilii, Semen Nelumbinis, this method is particularly suitable for the arrhythmia that calentura or prolonged illness cause.

The ARR patient of part is except that cardiopalmus, and is uncomfortable in chest easypro also often with pareordia paroxysmal discomfort, thready and hesitant pulse or irregularly intermittent and regularly intermittent pulse, and dialectical is qi depression to blood stasis, and the stagnation of QI is not smooth, and heart-yang is held back, so adopt vital energy regualting and blood circulation-promoting collateral dredging method to reach the multiple purpose of the arteries and veins of feeling at ease.As adopting prescriptions such as Rhizoma Cyperi, Rhizoma Chuanxiong, Bulbus Allii Macrostemonis, Fructus Aurantii, Radix Angelicae Sinensis, Semen Persicae, Radix Paeoniae Rubra, Radix Achyranthis Bidentatae, RADIX CURCUMAE, Lignum Sappan, Radix Salviae Miltiorrhizae, this method is better for the caused arrhythmia effect of coronary heart disease.

Because of it is attacked by the cold and evil, check the breast sun, blood vessels are obstructed, can cause severe palpitation, irregularly intermittent and regularly intermittent pulse, the patient also diseases such as aversion to cold and cold limbs, pale complexion, sensation of oppression over the chest with shortness of breath can occur, adopt hot fragrant Wen Tongfa, get its causing resuscitation with aromatic drugs, cold expellingization is turbid, to reach the cold beniol of dispelling, unfold the breast sun, improve the purpose of cardiac muscle and conducting system function.As adopt prescriptions such as Fructus Trichosanthis, Bulbus Allii Macrostemonis, Ramulus Cinnamomi, Lignum Santali Albi, Lignum Aquilariae Resinatum, Rhizoma Acori Graminei, Olibanum, this method to be applicable to diseases such as bradycardia, atrial fibrillation, I degree and the atrioventricular block of II degree.

Heart governing blood and vessels and house mind, if cloudy anemia is decreased, it is foster that the heart is become homeless, house mind's then refreshing uneasiness of dereliction of duty and will is not peaceful is sent out to be cardiopalmus, so tranquilizing by nourishing the heart also is to treat one of ARR method.As adopting Radix Codonopsis, the Radix Astragali, Radix Angelicae Sinensis, Herba Agrimoniae, Poria cum Radix Pini, Semen Ziziphi Spinosae, the Radix Paeoniae Alba, Radix Polygalae, Fructus Mori etc., this method is applicable to the diseases such as arrhythmia that atrial fibrillation, myocarditis cause.In addition, prove that treatment by Chinese herbs arrhythmia such as Rohdea japonica Roth, Folium Ginkgo, Radix Puerariae, Radix Sophorae Flavescentis have effect preferably,,, improve curative effect to assist treatment so can on dialectical basis, take the circumstances into consideration to select for use according to pharmacological research.

Summary of the invention

The object of the invention is to provide a kind of ARR pure Chinese medicinal preparation that is used for the treatment of, to alleviate the misery that cardiac arrhythmia brings to the patient;

The present invention also provides the raw material prescription and the preparation method of such preparation, realizes the large-scale production of medicine to help manufacturer, thereby promotes the development of Chinese medicine, improves the medication environment.

Be achieved through the following technical solutions order of the present invention:

1, the present invention is made by the following weight Chinese medicinal raw materials:

42～102 parts of 38～82 parts of Radix Ginsengs of the Radix Astragali 12～36 parts of Radix Ophiopogonis

38～82 parts of 42～102 portions of Rhizoma Coptidis of 12～36 parts of Radix Puerariaes of Radix Rehmanniae

42～102 parts of 42～102 portions of Fructus Gardeniaes of 38～82 parts of Fructus Schisandrae Chinensis of Radix Sophorae Flavescentis

38～82 parts of 38～82 parts of Radix Glycyrrhizae Preparatas of 12～36 parts of Herba Epimedii of Semen Platycladi

2, each raw material weight proportioning of the best of the present invention's prescription is:

80 parts of 68 parts of Radix Ginsengs of the Radix Astragali 22 parts of Radix Ophiopogonis

68 parts of 80 portions of Rhizoma Coptidis of 22 parts of Radix Puerariaes of Radix Rehmanniae

80 parts of 80 portions of Fructus Gardeniaes of 68 parts of Fructus Schisandrae Chinensis of Radix Sophorae Flavescentis

68 parts of 68 parts of Radix Glycyrrhizae Preparatas of 22 parts of Herba Epimedii of Semen Platycladi

3, this Chinese medicine preparation is to make by being prepared as follows method:

Above-mentioned 12 flavors,

(1) get the Radix Astragali, Radix Ginseng, Radix Ophiopogonis, Rhizoma Coptidis, Radix Sophorae Flavescentis, mix, decoct with water three times, add 6～10 times of amounts of water at every turn, decocted 1～2 hour at every turn, filter, merging filtrate, and be concentrated into the clear paste that relative density is 1.12～1.18 (60 ℃), standby;

(2) get seven flavors such as all the other Radix Rehmanniae, Radix Puerariae, add 10 times of amounts of water at every turn, decoct 3～5 times, each 1 hour, merge decocting liquid, filter, filtrate is concentrated into the clear paste that relative density is 1.10～1.16 (70 ℃), and is standby;

(3) get above-mentioned two standby clear paste and mix and stir evenly, add ethanol and make and contain the alcohol amount and reach 50～65% (V/V), cold preservation was left standstill 5～8 hours, got supernatant; Residual solution centrifuging and taking supernatant; Alcohol with corresponding concentration washs pure hypostasis, and is centrifugal, gets supernatant; Merge three times supernatant, decompression recycling ethanol is not distinguished the flavor of to there being alcohol, and is condensed into the thick paste that relative density is 1.32～1.39 (65～75 ℃), and is stand-by;

(4) get thick paste, it is an amount of to add dextrin or starch, and mixing, drying under reduced pressure become dried cream, are ground into fine powder, make the extract of above-mentioned raw materials medical material after, make granule, capsule, pill, capsule, tablet, mixture etc. through processes.

Of the present inventionly a kind ofly be used for the treatment of ARR pure Chinese medicinal preparation and form by the Radix Astragali, Radix Ginseng etc. 12 flavor Chinese crude drug prescriptions, after water decoction-alcohol sedimentation technology is extracted effective ingredient, the granule of making through processes, capsule, pill, capsule, tablet, mixture etc. belong to pure Chinese medicinal preparation.It has the effect of benefiting QI and nourishing blood, disperse blood stasis and dredge collateral, QI and blood abundance after the medication, and heart arteries and veins is fluent, thus the treatment cardiac arrhythmia, and have no side effect.

The specific embodiment of form is described in further detail foregoing of the present invention by the following examples.Following example is based on the above-mentioned subject area of the present invention, but is not limited to following example.

The specific embodiment

Embodiment 1: a kind ofly be used for the treatment of ARR granule

Adopt following prescription:

Radix Astragali 38g Radix Ginseng 12g 42g Radix Ophiopogonis

Radix Rehmanniae 12g Radix Puerariae 42g Rhizoma Coptidis 38g

Radix Sophorae Flavescentis 38g Fructus Schisandrae Chinensis 42g Fructus Gardeniae 42g

Semen Platycladi 12g Herba Epimedii 38g Radix Glycyrrhizae Preparata 38g

Make by being prepared as follows method:

Above-mentioned 12 flavors,

(1) get Radix Astragali 38g, Radix Ginseng 12g, Radix Ophiopogonis 42g, Rhizoma Coptidis 38g, Radix Sophorae Flavescentis 38g, mix, decoct with water three times, add 8 times of amounts of water at every turn, decocted 1 hour at every turn, filter, merging filtrate, and be concentrated into the clear paste that relative density is 1.16 (60 ℃), standby;

(2) get seven flavors such as all the other Radix Rehmanniae, Radix Puerariae, add 10 times of amounts of water at every turn, decoct 3 times, each 1 hour, merge decocting liquid, filter, filtrate is concentrated into the clear paste that relative density is 1.16 (70 ℃), and is standby;

(3) get above-mentioned two standby clear paste and mix and stir evenly, add ethanol and make and contain the alcohol amount and reach 50% (V/V), cold preservation was left standstill 5 hours, got supernatant; Residual solution centrifuging and taking supernatant; Washing with alcohol alcohol hypostasis with 50%, centrifugal, get supernatant; Merge three times supernatant, decompression recycling ethanol is not distinguished the flavor of to there being alcohol, and is condensed into the thick paste that relative density is 1.38 (65 ℃), and is stand-by;

(4) get thick paste, add the about 69g of dextrin, mixing, drying under reduced pressure become dried cream, are ground into fine powder, make the extract of above-mentioned raw materials medical material after, water is granulated, and sieves, forced air drying must granule, packing promptly gets granule.

Embodiment 2: a kind ofly be used for the treatment of ARR pill

Adopt following prescription:

Radix Astragali 68g Radix Ginseng 22g 80g Radix Ophiopogonis

Radix Rehmanniae 22g Radix Puerariae 80g Rhizoma Coptidis 68g

Radix Sophorae Flavescentis 68g Fructus Schisandrae Chinensis 80g Fructus Gardeniae 80g

Semen Platycladi 22g Herba Epimedii 68g Radix Glycyrrhizae Preparata 68g

Make by being prepared as follows method:

Above-mentioned 12 flavors,

(1) get Radix Astragali 68g, Radix Ginseng 22g, Radix Ophiopogonis 80g, Rhizoma Coptidis 68g, Radix Sophorae Flavescentis 68g, mix, decoct with water three times, add 8 times of amounts of water at every turn, decocted 1 hour at every turn, filter, merging filtrate, and be concentrated into the clear paste that relative density is 1.14 (60 ℃), standby;

(2) get seven flavors such as all the other Radix Rehmanniae, Radix Puerariae, add 10 times of amounts of water at every turn, decoct 4 times, each 1 hour, merge decocting liquid, filter, filtrate is concentrated into the clear paste that relative density is 1.14 (70 ℃), and is standby;

(3) get above-mentioned two standby clear paste and mix and stir evenly, add ethanol and make and contain the alcohol amount and reach 60% (V/V), cold preservation was left standstill 6 hours, got supernatant; Residual solution centrifuging and taking supernatant; Washing with alcohol alcohol hypostasis with 60%, centrifugal, get supernatant; Merge three times supernatant, decompression recycling ethanol is not distinguished the flavor of to there being alcohol, and is condensed into the thick paste that relative density is 1.36 (70 ℃), and is stand-by;

(4) get thick paste, add the about 100g of starch, mixing, drying under reduced pressure become dried cream, are ground into fine powder, make the extract of above-mentioned raw materials medical material after, use water pill, drying, polishing promptly gets the watered pill.

Embodiment 3: a kind ofly be used for the treatment of ARR tablet

Adopt following prescription:

Radix Astragali 82g Radix Ginseng 36g 102g Radix Ophiopogonis

Radix Rehmanniae 36g Radix Puerariae 102g Rhizoma Coptidis 82g

Radix Sophorae Flavescentis 82g Fructus Schisandrae Chinensis 102g Fructus Gardeniae 102g

Semen Platycladi 36g Herba Epimedii 82g Radix Glycyrrhizae Preparata 82g

Make by being prepared as follows method:

Above-mentioned 12 flavors,

(1) get Radix Astragali 82g, Radix Ginseng 36g, Radix Ophiopogonis 102g, Rhizoma Coptidis 82g, Radix Sophorae Flavescentis 82g, mix, decoct with water three times, add 10 times of amounts of water at every turn, decocted 1.5 hours at every turn, filter, merging filtrate, and be concentrated into the clear paste that relative density is 1.12 (60 ℃), standby;

(2) get seven flavors such as all the other Radix Rehmanniae, Radix Puerariae, add 10 times of amounts of water at every turn, decoct 5 times, each 1 hour, merge decocting liquid, filter, filtrate is concentrated into the clear paste that relative density is 1.12 (70 ℃), and is standby;

(3) get above-mentioned two standby clear paste and mix and stir evenly, add ethanol and make and contain the alcohol amount and reach 65% (V/V), cold preservation was left standstill 7 hours, got supernatant; Residual solution centrifuging and taking supernatant; Washing with alcohol alcohol hypostasis with 65%, centrifugal, get supernatant; Merge three times supernatant, decompression recycling ethanol is not distinguished the flavor of to there being alcohol, and is condensed into the thick paste that relative density is 1.32 (75 ℃), and is stand-by;

(4) get thick paste, add the about 55g of dextrin, the about 145g of starch, mixing, drying under reduced pressure become dried cream, are ground into fine powder, make the extract of above-mentioned raw materials medical material after, make granule with 70% ethanol, drying, tabletting is promptly.

Claims (3)

1, a kind ofly be used for the treatment of ARR pure Chinese medicinal preparation, it is characterized in that it comprises what unit of weight was made by the following raw material of Chinese medicine of part:

42～102 parts of 38～82 parts of Radix Ginsengs of the Radix Astragali 12～36 parts of Radix Ophiopogonis

38～82 parts of 42～102 portions of Rhizoma Coptidis of 12～36 parts of Radix Puerariaes of Radix Rehmanniae

42～102 parts of 42～102 portions of Fructus Gardeniaes of 38～82 parts of Fructus Schisandrae Chinensis of Radix Sophorae Flavescentis

38～82 parts of 38～82 parts of Radix Glycyrrhizae Preparatas of 12～36 parts of Herba Epimedii of Semen Platycladi.

2, a kind of ARR pure Chinese medicinal preparation that is used for the treatment of as claimed in claim 1 is characterized in that the weight proportion of each component is in the prescription:

80 parts of 68 parts of Radix Ginsengs of the Radix Astragali 22 parts of Radix Ophiopogonis

68 parts of 80 portions of Rhizoma Coptidis of 22 parts of Radix Puerariaes of Radix Rehmanniae

80 parts of 80 portions of Fructus Gardeniaes of 68 parts of Fructus Schisandrae Chinensis of Radix Sophorae Flavescentis

68 parts of 68 parts of Radix Glycyrrhizae Preparatas of 22 parts of Herba Epimedii of Semen Platycladi.

3,, it is characterized in that this Chinese medicine preparation is to make by being prepared as follows method as the described a kind of ARR pure Chinese medicinal preparation that is used for the treatment of of claim 1-2:

Above-mentioned 12 flavors,

(1) get the Radix Astragali, Radix Ginseng, Radix Ophiopogonis, Rhizoma Coptidis, Radix Sophorae Flavescentis, mix, decoct with water three times, add 6～10 times of amounts of water at every turn, decocted 1～2 hour at every turn, filter, merging filtrate, and be concentrated into the clear paste that relative density is 1.12～1.18 (60 ℃), standby;

(2) get seven flavors such as all the other Radix Rehmanniae, Radix Puerariae, add 10 times of amounts of water at every turn, decoct 3～5 times, each 1 hour, merge decocting liquid, filter, filtrate is concentrated into the clear paste that relative density is 1.10～1.16 (70 ℃), and is standby;

(3) get above-mentioned two standby clear paste and mix and stir evenly, add ethanol and make and contain the alcohol amount and reach 50～65% (V/V), cold preservation was left standstill 5～8 hours, got supernatant; Residual solution centrifuging and taking supernatant; Alcohol with corresponding concentration washs pure hypostasis, and is centrifugal, gets supernatant; Merge three times supernatant, decompression recycling ethanol is not distinguished the flavor of to there being alcohol, and is condensed into the thick paste that relative density is 1.32～1.39 (65～75 ℃), and is stand-by;

(4) get thick paste, it is an amount of to add dextrin or starch, and mixing, drying under reduced pressure become dried cream, are ground into fine powder, make the extract of above-mentioned raw materials medical material after, make granule, capsule, pill, capsule, tablet, mixture etc. through processes.