CN102370798A - Chinese medicinal compound preparation for treating IgA (Immunoglobulin A) nephropathy and preparation method thereof - Google Patents
Chinese medicinal compound preparation for treating IgA (Immunoglobulin A) nephropathy and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a compound Chinese medicinal preparation for treating IgA (Immunoglobulin A) nephropathy. The compound Chinese medicinal preparation comprises the following Chinese medicinal raw materials by weight: 13-17 grams of astragalus, 8-12 grams of rehmannia root, 8-12 grams of red-rooted salvia root, 8-12 grams of common bletilla pseudobulb, 2-4 grams of cicada shell, 8-12 grams of garden burnet root, 16-24 grams of cogongrass rhizome and 2-4 grams of Chinese caterpillar fungus (brewed). A preparation method of the compound Chinese medicinal preparation comprises the following steps of: cleaning the eight types of medicinal materials; mixing proportionally; adding water in an amount which is 6-8 times the total weight of the medicinal materials or 70 percent by volume of ethanol for decocting for three times, every time for 40 minutes; combining decoction solutions obtained in the three times; filtering; and concentrating to obtain a liquid extract of which the specific weight is 1.21 at 60 DEG C. The compound Chinese medicinal preparation can be prepared into any pharmaceutical dosage form, such as tablets, capsules, granules, oral liquid, pills and syrup with the conventional preparation process. The compound Chinese medicinal preparation prepared with the method has the advantages of great reduction in the concentrations of albuminuria and hematuria of patient suffering from IgA nephropathy, great improvement on the kidney function, remarkable curative effect and great reduction in side effects and untoward reactions.
Description
Technical field
The present invention relates to a kind of compound Chinese medicinal preparation of treating IgA nephropathy and preparation method thereof, belong to field of traditional Chinese.
Background technology
The IgA nephropathy is present domestic and international modal primary glomerulonephritis, refer to IgA or with IgA be main immunoglobulin in the glomerular mesangium district and the blood capillary button loop be and fill the air graininess or lumps deposition, caused a series of clinical and pathological changes.This disease accounts for the 10%-20% of primary glomerulopathy, and sickness rate such as Asian countries China, Japan, Singapore are higher, are 45%-50%, behind disease activity 20 a, have the patient of 20%-30% to proceed to renal failure.Its clinical manifestation is various, and histology's form changes weight and differs, and prognosis also differs greatly.Clinical manifestation is remarkable albuminuria (> 1-2 g/ d), with hypertension, existing renal function injury when making a definite diagnosis; Kidney pathology shows glomerular sclerosis, crescent formation, interstitial fibrosis and sclerosis of blood vessels person and often points out prognosis not good; Can develop into ESRD, be called progressivity IgA nephropathy.
Shortcomings such as the Western medicine of existing treatment IgA nephropathy is effective in cure not ideal enough, and side effect is big, and untoward reaction is many.
Summary of the invention
The object of the present invention is to provide a kind of Chinese traditional compound medicine of treating IgA nephropathy and preparation method thereof.
The present invention provides the compound Chinese medicinal preparation of a kind of Radix Astragali, the Radix Rehmanniae, Radix Salviae Miltiorrhizae, Pseudobulbus Bletillae (Rhizoma Bletillae), Periostracum Cicadae, Radix Sanguisorbae, Rhizoma Imperatae, Cordyceps (dashing) compatibility to be used to treat IgA nephropathy, has good efficacy, has significantly reduced side effect and untoward reaction.
Technical scheme of the present invention is following:
A kind of Chinese traditional compound medicine of treating IgA nephropathy comprises the following weight Chinese medicinal raw materials: Radix Astragali 13-17, Radix Rehmanniae 8-12, Radix Salviae Miltiorrhizae 8-12, Pseudobulbus Bletillae (Rhizoma Bletillae) 8-12, Periostracum Cicadae 2-4, Radix Sanguisorbae 8-12, Rhizoma Imperatae 16-24, Cordyceps (dashing) 2-4.
Wherein method for preparing is that above-mentioned 8 flavor medical materials are cleaned, and proportional mixing, the 6-8 that adds medical material gross weight water or volume ratio doubly is that 70% ethanol decocts 3 times; Each 40 minutes, merge 3 times decoction liquor, filter; And concentrate, proportion is 1.21 fluid extract when obtaining 60 ℃, adopts conventional preparation technology; Chinese medicine preparation of the present invention can be made into said dosage form on any pharmaceutics, like tablet, capsule, granule, oral liquid, pill, syrup.
The Chinese traditional compound medicine that Chinese medicine preparation of the present invention makes greatly reduces IgA nephropathy patient's the albuminuria and the concentration of hematuria, has improved renal function greatly, and is evident in efficacy, significantly reduced side effect and untoward reaction.
Specific embodiment
Embodiment 1:
A kind of Chinese traditional compound medicine of treating IgA nephropathy comprises the following weight Chinese medicinal raw materials: the Radix Astragali 13, the Radix Rehmanniae 8, Radix Salviae Miltiorrhizae 8, Pseudobulbus Bletillae (Rhizoma Bletillae) 8, Periostracum Cicadae 2, Radix Sanguisorbae 8, Rhizoma Imperatae 16, Cordyceps (dashing) 2.
Wherein method for preparing is that above-mentioned 8 flavor medical materials are cleaned, proportional mixing, and 6 times the decocting that adds the medical material gross weight boils 3 times, and each 40 minutes, merge 3 times decoction liquor, to filter, and concentrate, proportion is 1.21 fluid extract when obtaining 60 ℃.
Embodiment 2:
A kind of Chinese traditional compound medicine of treating IgA nephropathy comprises the following weight Chinese medicinal raw materials: the Radix Astragali 15, the Radix Rehmanniae 10, Radix Salviae Miltiorrhizae 10, Pseudobulbus Bletillae (Rhizoma Bletillae) 10, Periostracum Cicadae 3, Radix Sanguisorbae 10, Rhizoma Imperatae 20, Cordyceps (dashing) 3.
All the other are with embodiment 1.
Embodiment 3:
A kind of Chinese traditional compound medicine of treating IgA nephropathy comprises the following weight Chinese medicinal raw materials: the Radix Astragali 17, the Radix Rehmanniae 12, Radix Salviae Miltiorrhizae 12, Pseudobulbus Bletillae (Rhizoma Bletillae) 12, Periostracum Cicadae 4, Radix Sanguisorbae 12, Rhizoma Imperatae 24, Cordyceps (dashing) 4.
Wherein method for preparing is that above-mentioned 8 flavor medical materials are cleaned, proportional mixing, and 6 times of volume ratios that add the medical material gross weight are that 70% ethanol decocts 3 times, each 40 minutes, merges 3 times decoction liquor, filter, and concentrated, proportion is 1.21 fluid extract when obtaining 60 ℃.
Embodiment 4:
A kind of Chinese traditional compound medicine of treating IgA nephropathy comprises the following weight Chinese medicinal raw materials: the Radix Astragali 13, the Radix Rehmanniae 8, Radix Salviae Miltiorrhizae 8, Pseudobulbus Bletillae (Rhizoma Bletillae) 8, Periostracum Cicadae 2, Radix Sanguisorbae 8, Rhizoma Imperatae 16, Cordyceps (dashing) 2.
Wherein method for preparing is that above-mentioned 8 flavor medical materials are cleaned, proportional mixing, and 7 times of volume ratios that add the medical material gross weight are that 70% ethanol decocts 3 times, each 40 minutes, merges 3 times decoction liquor, filter, and concentrated, proportion is 1.21 fluid extract when obtaining 60 ℃.
Embodiment 5:
A kind of Chinese traditional compound medicine of treating IgA nephropathy comprises the following weight Chinese medicinal raw materials: the Radix Astragali 15, the Radix Rehmanniae 10, Radix Salviae Miltiorrhizae 10, Pseudobulbus Bletillae (Rhizoma Bletillae) 10, Periostracum Cicadae 3, Radix Sanguisorbae 10, Rhizoma Imperatae 20, Cordyceps (dashing) 3.
Wherein method for preparing is that above-mentioned 8 flavor medical materials are cleaned, proportional mixing, and 7 times the decocting that adds the medical material gross weight boils 3 times, and each 40 minutes, merge 3 times decoction liquor, to filter, and concentrate, proportion is 1.21 fluid extract when obtaining 60 ℃.
Embodiment 6:
A kind of Chinese traditional compound medicine of treating IgA nephropathy comprises the following weight Chinese medicinal raw materials: the Radix Astragali 17, the Radix Rehmanniae 12, Radix Salviae Miltiorrhizae 12, Pseudobulbus Bletillae (Rhizoma Bletillae) 12, Periostracum Cicadae 4, Radix Sanguisorbae 12, Rhizoma Imperatae 24, Cordyceps (dashing) 4.
Wherein method for preparing is that above-mentioned 8 flavor medical materials are cleaned, proportional mixing, and 7 times the decocting that adds the medical material gross weight boils 3 times, and each 40 minutes, merge 3 times decoction liquor, to filter, and concentrate, proportion is 1.21 fluid extract when obtaining 60 ℃.
Embodiment 7:
A kind of Chinese traditional compound medicine of treating IgA nephropathy comprises the following weight Chinese medicinal raw materials: the Radix Astragali 15, the Radix Rehmanniae 10, Radix Salviae Miltiorrhizae 10, Pseudobulbus Bletillae (Rhizoma Bletillae) 10, Periostracum Cicadae 3, Radix Sanguisorbae 10, Rhizoma Imperatae 20, Cordyceps (dashing) 3.
Wherein method for preparing is that above-mentioned 8 flavor medical materials are cleaned, proportional mixing, and 8 times of volume ratios that add the medical material gross weight are that 70% ethanol decocts 3 times, each 40 minutes, merges 3 times decoction liquor, filter, and concentrated, proportion is 1.21 fluid extract when obtaining 60 ℃.
Embodiment 8:
A kind of Chinese traditional compound medicine of treating IgA nephropathy comprises the following weight Chinese medicinal raw materials: the Radix Astragali 20, the Radix Rehmanniae 15, Radix Salviae Miltiorrhizae 15, Pseudobulbus Bletillae (Rhizoma Bletillae) 8, Periostracum Cicadae 2, Radix Sanguisorbae 8, Rhizoma Imperatae 15, Cordyceps (dashing) 2.
Wherein method for preparing is that above-mentioned 8 flavor medical materials are cleaned, proportional mixing, and 8 times the decocting that adds the medical material gross weight boils 3 times, and each 40 minutes, merge 3 times decoction liquor, to filter, and concentrate, proportion is 1.21 fluid extract when obtaining 60 ℃.
Embodiment 9:
A kind of Chinese traditional compound medicine of treating IgA nephropathy comprises the following weight Chinese medicinal raw materials: the Radix Astragali 10, the Radix Rehmanniae 5, Radix Salviae Miltiorrhizae 5, Pseudobulbus Bletillae (Rhizoma Bletillae) 12, Periostracum Cicadae 5, Radix Sanguisorbae 15, Rhizoma Imperatae 22, Cordyceps (dashing) 5.
Wherein method for preparing is that above-mentioned 8 flavor medical materials are cleaned, proportional mixing, and 8 times of volume ratios that add the medical material gross weight are that 70% ethanol decocts 3 times, each 40 minutes, merges 3 times decoction liquor, filter, and concentrated, proportion is 1.21 fluid extract when obtaining 60 ℃.
Embodiment 10:
A kind of Chinese traditional compound medicine of treating IgA nephropathy comprises the following weight Chinese medicinal raw materials: the Radix Astragali 12, the Radix Rehmanniae 12, Radix Salviae Miltiorrhizae 7, Pseudobulbus Bletillae (Rhizoma Bletillae) 13, Periostracum Cicadae 1, Radix Sanguisorbae 12, Rhizoma Imperatae 15, Cordyceps (dashing) 5.
Wherein method for preparing is that above-mentioned 8 flavor medical materials are cleaned, proportional mixing, and 5 times the water 5 that adds the medical material gross weight decocts 3 times, and each 40 minutes, merge 3 times decoction liquor, to filter, and concentrate, proportion is 1.21 fluid extract when obtaining 60 ℃.
Embodiment 11:
According to " traditional Chinese medical science forum " 2005; " LIUWEI DIHUANG TANG closes Radix Astragali warming YANG Tonga and subtracts treatment IgA nephropathy 50 examples " comprises following medicine composition: Radix Rehmanniae 25g, Poria 25g, Rhizoma Atractylodis Macrocephalae preparata 30g, Rhizoma Alismatis 20g, Ramulus Cinnamomi 20g, Radix Salviae Miltiorrhizae 25g, Fructus Corni 15g, Rhizoma Dioscoreae 30g, Radix Astragali Preparata 30g, windproof 15g, Radix Tripterygii Wilfordii 10g, Herba Ecliptae 20g, Herba Agrimoniae 15g, Herba Cirsii 20g, Rhizoma Imperatae 25g, Pericarpium Citri Reticulatae 10g, Radix Glycyrrhizae Preparata 10g in 20 (6).
Said medicine is used potion every day, with being decocted in water for oral dose.
Embodiment 12:
According to " the new traditional Chinese medical science " 2003; " nephritis is rather treated children's gA nephropathy 25 routine observation of curative effect " in 35 (4); Therapeutic Method is: the Radix Astragali, each 15g of Rhizoma Imperatae; Herba Hedyotidis Diffusae, each 12g of Radix Codonopsis, Herba Agrimoniae, Poria, the Rhizoma Atractylodis Macrocephalae, Fructus Ligustri Lucidi, Herba Ecliptae, Rhizoma Chuanxiong, each lOg of Radix Rehmanniae, Radix Notoginseng powder (dashing) 2g forms.Process electuary,
Every bag of 9g (containing cattle medicine 12.5g).Each 1.5 bags. every day 3 times, oral.
Embodiment 13: adopt conventional preparation technology, Chinese medicine preparation of the present invention can be made into said dosage form on any pharmaceutics, like tablet, capsule, granule, oral liquid, pill, syrup.
All the other are with embodiment 1-10.
Embodiment 14: the fluid extract of the mix homogeneously that will be made by embodiment 1-10 concentrates, and according to the operational approach of conventional tablet, adds pharmaceutic adjuvant; With each component mix homogeneously, wet granulation sieves; Adopt conventional tablet preparation method tabletting to process tablet, wherein each components contents is following:
Composition weight (part)
Mixed flow extractum 50
Starch 20
Microcrystalline Cellulose 12
Pulvis Talci 10
Polyethylene Glycol 8
All the other are with embodiment 1-10.
Embodiment 15: the fluid extract of the mix homogeneously that will be made by embodiment 1-10 concentrates, and according to the operational approach of conventional capsule, adds pharmaceutic adjuvant; With each component mix homogeneously; Granulate, adopt conventional capsule preparation method to fill and process capsule, wherein each components contents is following:
Composition weight (part)
Mixed flow extractum 100
Pregelatinized Starch 28
Lactis Anhydrous 18
Microcrystalline Cellulose 15
Calcium hydrogen phosphate 7
All the other are with embodiment 1-10.
Embodiment 16: the fluid extract of the mix homogeneously that will be made by embodiment 1-10 concentrates, according to the operational approach of conventional oral liquid, ethanol precipitation 1-2 time; Filter, concentrate aqueous precipitation; Filter, add pharmaceutic adjuvant, filter; The packing sterilization adopts conventional oral liquid preparation method to prepare oral liquid, and wherein each components contents is following:
Composition weight (part)
Mixed flow extractum 100
Ethanol 150
Sucrose 80
Sodium carboxymethyl cellulose 12
Oleum menthae 5
Sorbic acid 3
All the other are with embodiment 1-10.
Experimental example:
Randomly draw 130 routine IgA nephrotics in hospital, be divided into 13 groups at random: 120 examples are organized in treatment, male 69 examples, and women 51 examples in age 19-65 year, are divided into 12 groups by 1-12 embodiment, every group 10 example; Matched group 10 examples, male 6 examples, women 4 examples, age 21-58 year.
The treatment group: on the basis of conventional therapy, with the prepared Chinese medical concrete of embodiment 1-10 11 times of dilute with waters by volume, the Chinese medical concrete after the respectively oral embodiment 1-10 dilution of 10 treatment groups, each oral 100ml, each is once sooner or later; The medicine that oral embodiment 11 and embodiment 12 make is organized in remaining two groups of treatments.
Matched group: on the conventional therapy basis, take Glucosidorum Tripterygll Totorum, each 20 mg, every day 3 times is oral.
Treatment group and matched group were in hospital 30 days, tracing study 3 months, observe the curative effect and to the influence of 24 h urine protein quantitation and serum creatinine (SCr), endogenous creatinine clearance rate (CCr).
Criterion of therapeutical effect:
Alleviate fully: clinical symptoms, sign complete obiteration, routine urinalysis albumen and erythrocyte continue to disappear 3 months, 24 h urine protein quantitation 0.2 g, SCr is normal; Significantly alleviate: clinical symptoms, sign complete obiteration, routine urinalysis albumen and erythrocyte, 24 h urine protein quantitation reduce >=50%, continue 3 months, and SCr is normal; Take a turn for the better: clinical symptom remission, routine urinalysis albumen and erythrocyte, 24 h urine protein quantitation reduce >=25%, SCr
Stable; Invalid: as not reach above-mentioned standard person.
24 h urine protein quantitation and urine erythrocyte variation comparison before and after table 1 patient treatment (x ± s)
Annotate: with comparison after the treatment of control group, ▲ P < 0.05.
Renal function improves situation
SCr, CCr (x ± s) relatively before and after table 2 patient treatment
Annotate: relatively preceding with the treatment of this group, △ P < 0.05; With comparison after the treatment of control group, ▲ P < 0.05.
Total effects
Table 3 patient clinical efficacy relatively
| Group | ? | N | Alleviate fully | Significantly alleviate | Take a turn for the better | Invalid | Total effective rate (%) |
| The treatment group | Embodiment 1-7 | 70 | 38 | 17 | 10 | 5 | 92.86% |
| ? | Embodiment 8-12 | 50 | 15 | 12 | 8 | 15 | 70.00% |
| Matched group | ? | 10 | 2 | 3 | 1 | 4 | 60% |
Matched group patients with hepatic function alanine aminotransferase (ALT), alkali phosphatase (ALP) rising 4 examples (32.14%) in the therapeutic process, blood leukocytes, thrombocytopenia 3 examples (7.14%) appear in menoxenia or menolipsis 2 examples (17.86%); And the treatment group is not seen above-mentioned untoward reaction.
Therapeutic effect shows that Chinese traditional compound medicine that the present invention makes is superior to matched group at aspects such as improving patient's interior-heat caused by deficiency of YIN, pharyngalgia pharynx are red, feverish sensation in the palms and soles, oliguria with reddish urine, constipation, lumbago due to renal deficiency; Treatment back treatment group reduce by 24 h albuminuria quantitatively, alleviate and also be superior to matched group aspect the middle red blood cell of urine; Renal function improves situation and equally also is superior to matched group; And the curative effect that is superior to the Chinese medicine medicine that similar prescription makes in the prior art wherein with the best results of embodiment 5, and has no adverse reaction; Therefore the present invention can greatly reduce IgA nephropathy patient's the albuminuria and the concentration of hematuria; Improved renal function greatly, evident in efficacy, significantly reduced side effect and untoward reaction.
Claims (5)
1. a Chinese traditional compound medicine of treating IgA nephropathy comprises the following weight Chinese medicinal raw materials: Radix Astragali 13-17, Radix Rehmanniae 8-12, Radix Salviae Miltiorrhizae 8-12.
2. a Chinese traditional compound medicine of treating IgA nephropathy comprises the following weight Chinese medicinal raw materials: Radix Astragali 13-17, Radix Rehmanniae 8-12, Radix Salviae Miltiorrhizae 8-12, Pseudobulbus Bletillae (Rhizoma Bletillae) 8-12, Periostracum Cicadae 2-4, Radix Sanguisorbae 8-12, Rhizoma Imperatae 16-24, Cordyceps (dashing) 2-4.
3. a Chinese traditional compound medicine of treating IgA nephropathy comprises the following weight Chinese medicinal raw materials: the Radix Astragali 15, the Radix Rehmanniae 10, Radix Salviae Miltiorrhizae 10, Pseudobulbus Bletillae (Rhizoma Bletillae) 10, Periostracum Cicadae 3, Radix Sanguisorbae 10, Rhizoma Imperatae 20, Cordyceps (dashing) 3.
4. like claim 2 or 3 said a kind of method for preparinies of treating the Chinese traditional compound medicine of IgA nephropathy, it is characterized by: 8 flavor medical materials are cleaned proportional mixing; The 6-8 that adds medical material gross weight water or volume ratio doubly is that 70% ethanol decocts 3 times; Each 40 minutes, merge 3 times decoction liquor, filter; And concentrate; Proportion is 1.21 fluid extract when obtaining 60 ℃, adopts conventional preparation technology to process said dosage form on any pharmaceutics, like tablet, capsule, granule, oral liquid, pill, syrup.
5. a kind of method for preparing of treating the Chinese traditional compound medicine of IgA nephropathy as claimed in claim 4 is characterized by: 8 flavor medical materials are cleaned proportional mixing; 7 times the decocting that adds the medical material gross weight boils 3 times; Each 40 minutes, merge 3 times decoction liquor, filter; And concentrate, proportion is 1.21 fluid extract when obtaining 60 ℃; Adopt conventional preparation technology, Chinese medicine preparation of the present invention can be made into said dosage form on any pharmaceutics, like tablet, capsule, granule, oral liquid, pill, syrup.
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| CN201110364252.9A CN102370798B (en) | 2011-11-17 | 2011-11-17 | A kind of compound Chinese medicinal preparation for the treatment of IgA ephrosis and preparation method thereof |
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| CN201110364252.9A CN102370798B (en) | 2011-11-17 | 2011-11-17 | A kind of compound Chinese medicinal preparation for the treatment of IgA ephrosis and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102641402A (en) * | 2012-04-16 | 2012-08-22 | 辽宁中医药大学 | Preparation and quality control method of traditional Chinese medicine compound preparation for treating nephritis |
| CN103768201A (en) * | 2014-01-09 | 2014-05-07 | 刘金荣 | Traditional Chinese medicine preparation for treating qi stagnation and blood stasis IgA nephropathy |
| CN104606486A (en) * | 2015-01-04 | 2015-05-13 | 上海中医药大学附属龙华医院 | Traditional Chinese medicine composition for treating IgA nephropathy and application of composition |
| CN107184896A (en) * | 2017-06-27 | 2017-09-22 | 郑佳新 | A kind of traditional Chinese drug inspissation ball for treating IgA nephrosis |
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| CN1336180A (en) * | 2000-07-28 | 2002-02-20 | 辽宁中医学院附属医院 | Spot-eliminating and nephrosis-curing medicine |
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- 2011-11-17 CN CN201110364252.9A patent/CN102370798B/en not_active Expired - Fee Related
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| CN1336180A (en) * | 2000-07-28 | 2002-02-20 | 辽宁中医学院附属医院 | Spot-eliminating and nephrosis-curing medicine |
Non-Patent Citations (2)
| Title |
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| 唐德元: "固本清瘀汤治疗IgA肾病30例", 《陕西中医》, vol. 16, no. 10, 31 December 1995 (1995-12-31), pages 450 * |
| 徐晓明等: "自拟芪茜肾安汤治疗IgA肾病36例", 《辽宁中医药大学学报》, vol. 10, no. 12, 31 December 2008 (2008-12-31), pages 93 - 94 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102641402A (en) * | 2012-04-16 | 2012-08-22 | 辽宁中医药大学 | Preparation and quality control method of traditional Chinese medicine compound preparation for treating nephritis |
| CN103768201A (en) * | 2014-01-09 | 2014-05-07 | 刘金荣 | Traditional Chinese medicine preparation for treating qi stagnation and blood stasis IgA nephropathy |
| CN103768201B (en) * | 2014-01-09 | 2015-11-25 | 刘金荣 | A kind of Chinese medicine preparation for the treatment of qi stagnation and blood stasis type IgA nephropathy |
| CN104606486A (en) * | 2015-01-04 | 2015-05-13 | 上海中医药大学附属龙华医院 | Traditional Chinese medicine composition for treating IgA nephropathy and application of composition |
| CN104606486B (en) * | 2015-01-04 | 2018-01-05 | 上海中医药大学附属龙华医院 | A kind of Chinese medicine composition for treating IgA nephrosis and its application |
| CN107184896A (en) * | 2017-06-27 | 2017-09-22 | 郑佳新 | A kind of traditional Chinese drug inspissation ball for treating IgA nephrosis |
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