CN104398771A - Traditional Chinese medicine composition for treating diabetes - Google Patents
Traditional Chinese medicine composition for treating diabetes Download PDFInfo
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- CN104398771A CN104398771A CN201410781061.6A CN201410781061A CN104398771A CN 104398771 A CN104398771 A CN 104398771A CN 201410781061 A CN201410781061 A CN 201410781061A CN 104398771 A CN104398771 A CN 104398771A
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Abstract
The invention discloses a traditional Chinese medicine composition for treating diabetes. The traditional Chinese medicine composition is mainly prepared from the following traditional Chinese medicine raw materials in parts by weight: astragalus membranaceus, radices trichosanthis, hairyvein agrimony, Chinese yam, polygonum multiflorum, dogwood, radix scrophulariae, rhizoma anemarrhenae and rhizoma atractylodis. The traditional Chinese medicine composition has the effects of tonifying qi and yin as well as helping produce saliva and slaking thirst, is applicable to treatment on type-II diabetes, and can be used for treating diseases such as fatigue and weakness, xerostomia, polydipsia and the like.
Description
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to a kind of Chinese medicine composition for the treatment of diabetes.
Background technology
Diabetes are a kind of commonly encountered diseases, and along with economic development, the change of the living environments such as industrial pollution, onset diabetes rate increases very fast, and has rejuvenation trend.Diabetes divide type i diabetes and type ii diabetes.Type i diabetes is multiple is born in teenager, and clinical manifestation is hypoinsulinism, and body must rely on exogenous insulin existence.During type ii diabetes is more common in, old people, clinical manifestation be body to insulin insensitivity, the secretory volume of insulin is not low, even higher, i.e. insulin resistant (IR).In diabetes loyalty person, the ratio shared by type ii diabetes is about 95%.If type ii diabetes loyalty person glycemic control is bad, the blood capillary that diabetes are brought and macrovascular complications, will cause cardiovascular disease secondary, dyslipidemia, blind, renal failure and amputation etc., the health and lives of serious harm people.
The medicine of current treatment type ii diabetes is divided into biology, chemical drugs and Chinese medicine, and biological medicament is insulin, chemical drugs mainly based on sulfonylureas, biguanide drug, DPPIV, voglibose, row ketone etc., Chinese medicine with diabetes pill etc. for main representative.Though chemical drugs class Western medicine blood sugar reducing function is obvious, easily there is as anti-in hypoglycemia, hepatorenal damage, lactic acidosis, gastrointestinal tract, lesions of liver and kidney, increase the weight of cardiovascular complication etc. in long-term taking.
TCM Treatment of Diabetes is with a long history, discusses a lot in Chinese medicine document, sporadically appears in the disease such as " quenching one's thirst ", " eliminating mass ", " yearningly profit ", " three disappear ".Just on the books in Huangdi's Internal Classics before more than 2000 year Christian era, in long-term medical practice, the traditional Chinese medical science have accumulated the abundant experience of preventing and treating diabetes and complication thereof.TCM treatment of diabetes more holistic regulates and controls, and blood sugar reducing function is gentle, stable, evident in efficacy to the control of chronic complicating diseases of diabetes.Do not think drink, fatigue and weak to elimination xerostomia, the diabetic symptoms such as weak hyperhidrosis have good efficacy; Toxic and side effects is little, treating both the principal and secondary aspects of a disease, improve body.Lack the significant modern Chinese medicine of drug effect in Chinese patent medicine, still can not meet the needs of the diabetes loyalty person of clinical application.
Summary of the invention
The present invention relates to a kind of Chinese medicine composition for the treatment of diabetes, is a kind of drug composition for the treatment of type ii diabetes specifically.Said composition has supplementing QI and nourishing YIN, promoting the production of body fluid to quench thirst, is applicable to type ii diabetes treatment, improves fatigue and weakness, the diseases such as xerostomia tongue is made an uproar, excessive thirst polydipsia.
One of the present invention treats Chinese medicine for treating diabetes compositions, and the raw material of Chinese medicine primarily of following weight portion forms: Radix Astragali 350-380 part, Rhizoma Dioscoreae 270-290 part, Fructus Corni 270-290 part, Radix Polygoni Multiflori 180-190 part, Herba Agrimoniae 550-560 part, Radix Scrophulariae 270-290 part, Radix Trichosanthis 180-190 part, Rhizoma Anemarrhenae 180-190 part and Rhizoma Atractylodis 180-190 part.
Preferably, Chinese medicine composition of the present invention, the raw material of Chinese medicine primarily of following weight portion forms: the Radix Astragali 370 parts, Rhizoma Dioscoreae 278 parts, Fructus Corni 278 parts, Radix Polygoni Multiflori 185 parts, Herba Agrimoniae 556 parts, Radix Scrophulariae 278 parts, Radix Trichosanthis 185 parts, the Rhizoma Anemarrhenae 185 parts and Rhizoma Atractylodis 185 parts.
Preferred, Chinese medicine composition of the present invention forms primarily of the raw material of Chinese medicine of following weight: Radix Astragali 370g, Rhizoma Dioscoreae 278g, Fructus Corni 278g, Radix Polygoni Multiflori 185g, Herba Agrimoniae 556g, Radix Scrophulariae 278g, Radix Trichosanthis 185g, Rhizoma Anemarrhenae 185g and Rhizoma Atractylodis 185g.
The Chinese medicine composition of the invention described above, can be processed into the oral dosage form such as oral liquid, granule, tablet, capsule, pill or powder, is preferably granule.
Specifically, above-mentioned Chinese medicine composition is extracted into extractum, then is mixed and made into the oral dosage form such as oral liquid, granule, tablet, capsule, pill or powder with pharmaceutic adjuvant, be preferably granule.Described pharmaceutic adjuvant is all the adjuvant of this area routine, and as filler, disintegrating agent, binding agent etc., preparation method is also conventional method.
Present invention also offers a kind of method preparing the Chinese medicine composition for the treatment of diabetes of the present invention, comprise the following steps:
1) Radix Astragali of weight portion, Radix Trichosanthis, Herba Agrimoniae, Rhizoma Dioscoreae, Radix Polygoni Multiflori, Fructus Corni, Radix Scrophulariae, the Rhizoma Anemarrhenae, Rhizoma Atractylodis are cleaned, join in multi-function extractor and decoct three times, first time adds the soak by water 2 hours of 10 times amount, filters; Second time adds the soak by water 1 hour of 8 times amount, filters; Third time adds the soak by water 1 hour of 6 times amount, filters, merges three filtrates;
2) filtrate of upper step to be passed in two effect energy-saving concentrators concentrated, to be concentrated to after a certain amount of, proceeded in spherical concentrator by filter and continue concentrated, be concentrated into when relative density is the thick paste of 1.27-1.33 (60 DEG C) and obtain extractum;
3) extractum and pharmaceutic adjuvant are mixed and made into the oral dosage form such as oral liquid, granule, tablet, capsule, pill or powder, are preferably granule.
The method of the invention described above, preferably, mixes extractum with the weight ratio of adjuvant dextrin by 1:2, and obtained granule, loads dress.Every bag containing extractum 3g.
Chinese medicine composition of the present invention, with granular form, takes.Instructions of taking, boiled water is taken after mixing it with water, one time 2 bags, 3 times on the one.After glucose in urine is normal, 1 bag of 3g, 3 times on the one.
Detailed description of the invention:
Following examples are used for understanding essence of the present invention further, but do not limit the scope of the invention with this.
Embodiment 1
The Chinese medicine composition for the treatment of diabetes, its raw material of Chinese medicine (weight portion) is composed as follows:
The Radix Astragali 370 parts, Rhizoma Dioscoreae 278 parts, Fructus Corni 278 parts, Radix Polygoni Multiflori 185 parts, Herba Agrimoniae 556 parts, Radix Scrophulariae 278 parts, Radix Trichosanthis 185 parts, the Rhizoma Anemarrhenae 185 parts, Rhizoma Atractylodis 185 parts.
Prepare the technique of extractum and preparation thereof, step is as follows:
1) Radix Astragali of weight portion, Radix Trichosanthis, Herba Agrimoniae, Rhizoma Dioscoreae, Radix Polygoni Multiflori, Fructus Corni, Radix Scrophulariae, the Rhizoma Anemarrhenae, Rhizoma Atractylodis are cleaned, join in multi-function extractor and decoct three times, first time adds the soak by water 2 hours of 10 times amount, filters; Second time adds the soak by water 1 hour of 8 times amount, filters; Third time adds the soak by water 1 hour of 6 times amount, filters, merges three filtrates;
2) filtrate of upper step to be passed in two effect energy-saving concentrators concentrated, to be concentrated to after a certain amount of, proceeded in spherical concentrator by filter and continue concentrated, be concentrated into when relative density is the thick paste of 1.27-1.33 (60 DEG C) and obtain extractum;
3) extractum and pharmaceutic adjuvant are mixed and made into the oral dosage form such as oral liquid, granule, tablet, capsule, pill or powder, are preferably granule.
Preferably, by step 2) extractum and adjuvant dextrin press the weight ratio mix and blend of 1:2, granulate, granulate, obtained granule, loads dress, obtained granule.Every bag containing extractum 3g.
Embodiment 2
The Chinese medicine composition for the treatment of diabetes, its raw material of Chinese medicine (weight) is composed as follows: Radix Astragali 370g, Rhizoma Dioscoreae 278g, Fructus Corni 278g, Radix Polygoni Multiflori 185g, Herba Agrimoniae 556g, Radix Scrophulariae 278g, Radix Trichosanthis 185g, Rhizoma Anemarrhenae 185g, Rhizoma Atractylodis 185g.
The extractum of this Chinese medicine composition and the preparation technology of preparation as follows:
1) Radix Astragali of recipe quantity, Radix Trichosanthis, Herba Agrimoniae, Rhizoma Dioscoreae, Radix Polygoni Multiflori, Fructus Corni, Radix Scrophulariae, the Rhizoma Anemarrhenae, Rhizoma Atractylodis are cleaned, join in multi-function extractor and decoct three times, first time adds the soak by water 2 hours of 10 times amount, filters; Second time adds the soak by water 1 hour of 8 times amount, filters; Third time adds the soak by water 1 hour of 6 times amount, filters, merges three filtrates;
2) filtrate of upper step to be passed in two effect energy-saving concentrators concentrated, to be concentrated to after a certain amount of, proceeded in spherical concentrator by filter and continue concentrated, be concentrated into when relative density is the thick paste of 1.27-1.33 (60 DEG C) and obtain extractum;
3) extractum and pharmaceutic adjuvant are mixed and made into the oral dosage form such as oral liquid, granule, tablet, capsule, pill or powder, are preferably granule.
Preferably, by step 2) extractum and adjuvant dextrin press the weight ratio mix and blend of 1:2, granulate, granulate, obtained granule, loads dress, obtained granule.Every bag containing extractum 3g.
Embodiment 3
The Chinese medicine composition for the treatment of diabetes, its raw material of Chinese medicine (weight portion) is composed as follows: the Radix Astragali 350 parts, Rhizoma Dioscoreae 290 parts, Fructus Corni 290 parts, Radix Polygoni Multiflori 180 parts, Herba Agrimoniae 560 parts, Radix Scrophulariae 270 parts, Radix Trichosanthis 190 parts, the Rhizoma Anemarrhenae 180 parts, Rhizoma Atractylodis 190 parts.
The preparation technology of extractum and preparation is with reference to embodiment 1 or 2
Embodiment 4
The Chinese medicine composition for the treatment of diabetes, its raw material of Chinese medicine (weight portion) is composed as follows: the Radix Astragali 380 parts, Rhizoma Dioscoreae 270 parts, Fructus Corni 270 parts, Radix Polygoni Multiflori 190 parts, Herba Agrimoniae 550 parts, Radix Scrophulariae 290 parts, Radix Trichosanthis 18 parts, the Rhizoma Anemarrhenae 190 parts, Rhizoma Atractylodis 180 parts.
The preparation technology of extractum and preparation is with reference to embodiment 1 or 2.
Embodiment 5 clinical trial
Enter test type ii diabetes patient: totally 90 examples, wherein, man 66 example, female 24 example, minimum 40 years old of age, maximum 70 years old, fat 30 examples of build, medium 18 examples of build, build become thin 32 example, the course of disease is the longest 8 years, the shortest June, fasting glucose >28.1mmol/L 5 example, fasting glucose >18.0mmol/L 6 example, fasting glucose >10.1mmol/L 30 example, fasting glucose >7.5mmol/L 49 example, glucose in urine (+++) 10 example, glucose in urine (++) 15 example, glucose in urine (+) 20 example, glucose in urine (-) 35 example, complicated hypertension, 40 examples of hyperlipidemia, clinical manifestation is polydipsia, polyphagia, become thin 43 example, show as polydipsia, polyuria, weak, poor appetite obviously do not become thin person 20 example, show as polydipsia, polyuria, polyphagia is without 47 examples of becoming thin.
Take diabetes pill therapist 23 example before test, take 20 examples of diabetes pill, Or Metformin In Treating, with insulin twice daily, 2 examples of each 12u treatment.
Medication:
Patient stops using all hypoglycemic medicines taken before this, then uses the granule of warm boiled water embodiment 2, and each serving with 3g, every day 3 times 20 days was 1 course for the treatment of.
Curative effect judging standard:
Cure: clinical symptoms polydipsia, polyphagia, polyuria disappear, chemical examination fasting glucose is less than 6.3mmol/L, glucose in urine (-);
Effective: clinical symptoms, sign disappear, chemical examination fasting glucose <7.0mmol/L, glucose in urine (-);
Effective: clinical symptoms, sign take a turn for the better, fasting glucose <8.5mmol/L, glucose in urine (-);
Invalid: fasting glucose is greater than 12mmol/L, glucose in urine > (+) or the rear blood glucose for the treatment of raise.
Result of the test:
Cure 60 examples and account for 66.7%, effective 27 examples account for 30%, and effective 2 examples account for 2.2%, and invalid 1 example accounts for 1.1%,
Untoward reaction: feel stomach discomfort after few patients's medication, substantially without other side reaction, particularly occurs without hypoglycemic effect.
Through above-mentioned experiment, Chinese medicine composition of the present invention, treatment type ii diabetes excellent effect, substantially has no adverse reaction, is suitable for type ii diabetes patient long-term taking.
Through test, the Chinese medicine composition of embodiment 1,3 and 4 also has the curative effect suitable with the Chinese medicine composition of embodiment 2.
The basis of spirit of the present invention increasing and decreasing at double or simply adds and subtracts is all scope of the present invention.
Claims (7)
1. treat a Chinese medicine composition for diabetes, the raw material of Chinese medicine primarily of following weight portion forms: Radix Astragali 350-380 part, Rhizoma Dioscoreae 270-290 part, Fructus Corni 270-290 part, Radix Polygoni Multiflori 180-190 part, Herba Agrimoniae 550-560 part, Radix Scrophulariae 270-290 part, Radix Trichosanthis 180-190 part, Rhizoma Anemarrhenae 180-190 part and Rhizoma Atractylodis 180-190 part.
2. compositions as claimed in claim 1, the raw material of Chinese medicine primarily of following weight portion forms: the Radix Astragali 370 parts, Rhizoma Dioscoreae 278 parts, Fructus Corni 278 parts, Radix Polygoni Multiflori 185 parts, Herba Agrimoniae 556 parts, Radix Scrophulariae 278 parts, Radix Trichosanthis 185 parts, the Rhizoma Anemarrhenae 185 parts and Rhizoma Atractylodis 185 parts.
3. compositions as claimed in claim 2, the raw material of Chinese medicine primarily of following weight forms: Radix Astragali 370g, Rhizoma Dioscoreae 278g, Fructus Corni 278g, Radix Polygoni Multiflori 185g, Herba Agrimoniae 556g, Radix Scrophulariae 278g, Radix Trichosanthis 185g, Rhizoma Anemarrhenae 185g and Rhizoma Atractylodis 185g.
4. the arbitrary described compositions of claim 1-3, its dosage form is oral liquid, granule, tablet, capsule, pill or powder.
5. compositions as claimed in claim 4, its dosage form is granule.
6. prepare a method for the compositions of claim 5, the dosage form of described compositions is granule, and its method comprises the following steps:
1) Radix Astragali of weight portion, Radix Trichosanthis, Herba Agrimoniae, Rhizoma Dioscoreae, Radix Polygoni Multiflori, Fructus Corni, Radix Scrophulariae, the Rhizoma Anemarrhenae, Rhizoma Atractylodis are cleaned, join in multi-function extractor and decoct three times, filter, merging filtrate;
2) when the heating of the filtrate of upper step being concentrated into 60 DEG C, relative density is that the thick paste of 1.27-1.33 obtains extractum;
3) extractum and pharmaceutic adjuvant are mixed and made into oral liquid, granule, capsule, pill or powder.
7. method as claimed in claim 6, described step 1) in decoction comprise the soak by water 2 hours that first time adds 10 times amount for three times, second time adds the soak by water 1 hour of 8 times amount, and third time adds the soak by water 1 hour of 6 times amount.
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| CN105943823A (en) * | 2016-05-24 | 2016-09-21 | 成都市斯贝佳科技有限公司 | Traditional Chinese medicine composition for treating diabetes |
| CN105943841A (en) * | 2016-05-24 | 2016-09-21 | 成都市斯贝佳科技有限公司 | Traditional Chinese medicine composition for treating type II diabetes |
| CN105998609A (en) * | 2016-05-24 | 2016-10-12 | 成都市斯贝佳科技有限公司 | Traditional Chinese medicine preparation for treating diabetes mellitus |
| CN113041314A (en) * | 2021-03-29 | 2021-06-29 | 天圣制药集团股份有限公司 | Traditional Chinese medicine preparation for treating type II diabetes and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105943823A (en) * | 2016-05-24 | 2016-09-21 | 成都市斯贝佳科技有限公司 | Traditional Chinese medicine composition for treating diabetes |
| CN105943841A (en) * | 2016-05-24 | 2016-09-21 | 成都市斯贝佳科技有限公司 | Traditional Chinese medicine composition for treating type II diabetes |
| CN105998609A (en) * | 2016-05-24 | 2016-10-12 | 成都市斯贝佳科技有限公司 | Traditional Chinese medicine preparation for treating diabetes mellitus |
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