CN101947296A - Chinese medicine composition for treating diabetes - Google Patents
Chinese medicine composition for treating diabetes Download PDFInfo
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- CN101947296A CN101947296A CN2010102751793A CN201010275179A CN101947296A CN 101947296 A CN101947296 A CN 101947296A CN 2010102751793 A CN2010102751793 A CN 2010102751793A CN 201010275179 A CN201010275179 A CN 201010275179A CN 101947296 A CN101947296 A CN 101947296A
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Abstract
The invention relates to a Chinese medicine composition for treating diabetes, consisting of the following raw materials by weight proportion: 13-17 of radices trichosanthis, 18-22 of dried rhizome of rehmannia, 13-17 of scrophularia ningpoensis, 13-17 of rhizoma anemarrhenae, 13-17 of dogwood, 28-32 of radix astragali, 18-22 of Chinese yam, 13-17 of rhizoma atractylodis, 18-22 of coix seed, 10-14 of ophiopogon root, 28-32 of gypsum and 18-22 of root of kudzu vine. The composition has good effect on diabetes treatment and low price.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition for the treatment of diabetes.
Background technology
Chinese patent once disclosed " a kind of powder for the treatment of diabetes ", (China, publication number CN1389235A, open day on January 8th, 2003), this powder comprise main pay two groups of Chinese medicines wherein principal agent be to form by preparation of raw material such as Radix Rehmanniae Preparata, Radix Scrophulariae, Radix Ophiopogonis, Fructus Corni, the Radix Rehmanniae, Semen Sinapis Albae, pollen, Flos Chrysanthemi, paying a medicine is to be formed by preparation of raw material such as Radix Paeoniae Alba (parched), Cortex Moutan, wonderful Rhizomadioscoreae, Poria, Fructus Corni, Rhizoma Alismatis, Radix Rehmanniae Preparata, Rhizoma Coptidis, Radix Angelicae Sinensis, Radix Ophiopogonis, Cortex Cinnamomis.
Chinese patent once disclosed " a kind of medicines of new treatment diabetes ", (China, publication number CN1411838A, open day on April 23rd, 2003), it is to be raw material with Fructus Crataegi, Fructus Lycii, Fructus Momordicae charantiae, Flos Chrysanthemi, Semen Cassiae, Semen Coicis, Rhizoma Dioscoreae, Poria, Semen sojae atricolor, according to the different qualities of every flavor Chinese medicine, pretreatment such as scoop up with lyophilizing or air-dry pulverizing, solvent respectively after, preparation is in proportion made powder or piece agent through ripening, sterilization again.
Chinese patent once disclosed " treatment diabetes medicament ", (China, publication number CN1413633A, open day on April 30th, 2003), a kind of single medicinal material Cortex Mori that adopts is used to reduce post-prandial glycemia by extracting the medicament of its active component-Cortex Mori polysaccharide preparation.Another kind is the medicament that is extracted the dried cream preparation of gained by Cortex Mori and salviamiltiorrhizabung, is used to reduce post-prandial glycemia and while blood circulation promoting and blood stasis dispelling, and blood circulation promoting helps the generation and the development of delaying complications of diabetes and reduces the infringement of complication to the patient.
Chinese patent once disclosed " a kind of treat the Chinese medicinal capsule that diabetes are used ", (China, publication number CN1419921A, open day on May 28th, 2003), ingredient is Radix Codonopsis, Radix Adenophorae (Radix Glehniae), the Cortex Eucommiae, the Radix Rehmanniae, Radix Salviae Miltiorrhizae, Mulberry Octopus ocellatus Gray, Radix Trichosanthis, Radix Ophiopogonis and Rhizoma Dioscoreae, and the Chinese medicine fine particle is about 130 orders.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine composition for the treatment of diabetes, its treatment diabetes is effective, and cheap.
For achieving the above object, the solution that the present invention takes is: a kind of Chinese medicine composition for the treatment of diabetes, it is made up of the following weight proportion raw material: Radix Trichosanthis 13-17, Radix Rehmanniae 18-22, Radix Scrophulariae 13-17, Rhizoma Anemarrhenae 13-17, Fructus Corni 13-17, Radix Astragali 28-32, Rhizoma Dioscoreae 18-22, Rhizoma Atractylodis 13-17, Semen Coicis 18-22, Radix Ophiopogonis 10-14, Gypsum Fibrosum 28-32, Radix Puerariae 18-22.
The pharmacological action of Radix Trichosanthis, trichosanthin has the effect of induced labor and interruption of pregnancy, immune system there is inhibition and stimulates dual function, to colon cancer, hepatocarcinoma, in various degree stomach cancer cell and the efficient direct killing effect of the equal tool of Y2S oncogene positive cell, also have anti AIDS virus (HIV) duplicating in the immunocyte that infects, reduce the competent cell number that is infected by the virus in the immunocyte.Experiment shows that THFPS has hypoglycemic activity, and decoct is to Hemolytic streptococcus, and streptococcus pneumoniae etc. all have inhibitory action.
The pharmacological action of the Radix Rehmanniae: the Radix Rehmanniae water decoction forms the obvious inhibitory action of cell tool to Flos Rosae Rugosae in the mouse spleen, can obviously promote activatory splenocyte DNA of con A and proteinic biosynthesis, lymphocyte transformation to human body has facilitation, Radix Rehmanniae can be corrected the increase of hyperthyroidism rat kidney beta-receptor quantity, thyroid function is returned to normally, Radix Rehmanniae has the mice of quickening pluripotential hemopoietic stem cell, the propagation of bone marrow granulocyte hemopoietic progenitor cell, differentiation.Experiment finds that also Radix Rehmanniae has anti-radiation, antioxidation, anti-hypoxia, antifungal, the effect of blood sugar lowering.
The pharmacological action of Radix Scrophulariae: the water logging agent of Radix Scrophulariae, alcohol preserved material and water decoction have hypotensive effect, more obvious to the renal hypertension antihypertensive effect, Radix Scrophulariae water logging agent has maincenter calmness and anticonvulsant action, total yellow cave class aglycon has antiinflammatory action, and the Radix Scrophulariae leaf preparation has remarkable vitro inhibition staphylococcus aureus, Bacillus typhi with the Yangyin Qingfei Tang that contains Radix Scrophulariae, bacillus pyocyaneus, group B streptococcus, escherichia coli, shigella flexneri, the effect of diphtheria corynebacterium, and in the energy and diphtheria toxin, diphtherotoxin, multiple fungus is had inhibitory action, also have calm, anti-frightened, analgesic and fall the effect of blood grain.
The pharmacological action of the Rhizoma Anemarrhenae: Rhizoma Anemarrhenae decoct external to dysentery bacterium, typhoid fever and Salmonella paratyphi, escherichia coli, streptococcus pneumoniae, the staphylococcus and the dermatophytes of causing a disease have inhibitory action, water logging agent and Rhizoma Anemarrhenae sugar have hypoglycemic activity, Rhizoma Anemarrhenae extractum has refrigeration function to fever in rabbit, metabolism in vivo has retarding action to adrenocortical hormone, Rhizoma Anemarrhenae total saponins is to ADP, inductive rabbit of 5-HT and AA and human platelet aggregation have very strong inhibitory action, and anemaran can make blood glucose of mice and hepatic glycogen content obviously reduce, and lipids contents does not almost change.
The pharmacological action of Fructus Corni: Fructus Corni has hypoglycemic activity to the diabetes model animal rat that streptozocin (STZ) brings out, and it is invalid further to study water extract, and ether extract is effective, and its effective ingredient is mainly can fruit acid.The alcohol extract of Fructus Corni does not have obvious influence to the blood glucose of normal rat, and the diabetes model animal by epinephrine or model induced by alloxan is had obvious hypoglycemic effect, and can reduce the whole blood viscosity and the platelet aggregation of hyperglycemia animal, think that Fructus Corni may have therapeutic effect to the patient of 1 type (insulin-dependent) diabetes.
The pharmacological action of the Radix Astragali, the injection of astragalus polysaccharides mouse peritoneal, blood glucose there is the two-phase regulating action, can make that the mouse blood sugar level significantly descends behind the glucose load, and the mouse blood sugar that can obviously cause to antiadrenergic drug raise and react, and phenformin is caused mouse experiment hypoglycemia significantly anti-effect is arranged, and islets of langerhans disposition hypoglycemia is not had obvious influence.The Radix Astragali especially has the better prevention effect to diabetic nephropathy to improving the clinical symptoms of diabetes.The Radix Astragali can reduce urine protein, alleviates nephropathy, improves renal function.The Radix Astragali has the effect of blood sugar regulation, and the Radix Astragali has the liver protecting and promotes the effect of intestinal digestive function.The Radix Astragali has calmness, analgesia, antitumor, defying age, resisting pathogenic microbes and immunoregulation effect.
The pharmacological action of Rhizoma Dioscoreae: the Rhizoma Dioscoreae infusion has the effect that promotes the interferon generation and increase the T cell number, can suppress tumor cell proliferation, and certain anticancer function is arranged, and motion has the two-phase regulating action to intestine in vitro.The Rhizoma Dioscoreae water extract has the elimination urine protein, recovers the renal function effect.Chinese yam polysaccharide energy raise immunity has antioxidation, anti-aging effects.Rhizoma Dioscoreae can significantly reduce the blood glucose of normal mouse, the mice diabetes that can prevent alloxan to cause cause that to alloxan the mice diabetes have obvious blood sugar lowering and effect for reducing blood fat, and the low hepatic glycogen level of rising diabetic mice, improve myocardium glycogen content, be significantly smaller than glyburide but render a service, and required dosage is bigger, and the mouse blood sugar that can be obviously epinephrine and glucose be caused raises.Chinese yam polysaccharide has obvious reduction effect to the blood glucose of diabetes rat, and the C peptide content can raise simultaneously.
The pharmacological action of Rhizoma Atractylodis: Rhizoma Atractylodis decoct or pure preserved material 8g/kg are oral, normal rabbits blood glucose is slightly raise, and with its decoct 10g/kg, filling is raised, also obtain effect same, but raise with the filling of dosage decoct, decline after then blood glucose slightly raises to diabetic rabbit is in 10 days of perfusion, blood glucose constantly descends, significant difference, drug withdrawal 7-14 day, blood glucose is not seen the preceding level of medication that rises to.Potassium atractylate has hypoglycemic activity to mice, big pika and dog, reduce muscle glycogen and hepatic glycogen simultaneously, suppress glycogenesis, oxygen consumption is reduced, the blood lactic acid content increases, its blood sugar reducing function may be relevant with its inhibition to pasteur effect in the body, thereby suppress oxidation phosphatase effect in the cell, the transfer process of interfering energy.Single Rhizoma Atractylodis decoct 22g/kg successive administration 30 days is found it to blood glucose, and glycated protein does not have influence, and amount of insulin secretion height also irregularities changes.
The pharmacological action of Semen Coicis (having another name called Semen Coicis), the Semen Coicis ethanol extraction can suppress the propagation of ehrlich ascites cell, the life span of significant prolongation mice.Think that in early days coixenolide is anticancer effective ingredient, the existing analysis confirms that unsaturated fatty acid (linoleic acid) is main anticancer component; Semen Coicis oil can suppress the contraction of Rana nigromaculata skeletal muscle, and this effect is with to contain satisfied fatty acid relevant.Semen Coicis oil has excitation to isolated frog heart, is inhibitory action during high concentration.Semen Coicis Polysaccharide A, B, C have blood sugar reducing function, and the blood sugar reducing function with the Semen Coicis Polysaccharide A is the strongest especially.The Semen Coicis hot water extract has the effect of enhancing body humoral immunization, also has town's disease, effects such as antipyretic and anti-inflammatory.The Semen Coicis lactone has slight hypoglycemic activity to rabbit; the Semen Coicis polysaccharide has remarkable blood sugar reducing function; mainly be by improving SOD activity in the body; suppress the damage of oxygen-derived free radicals to the β cell membrane; play the generation that is used for suppressing alloxan diabetes of protection β cell; also can suppress the decomposition of glycogen and promote sugared different effect, can be used for polytype diabetes.
The pharmacological action of Radix Ophiopogonis: oral water, alcohol extract can make tame rabbit blood glucose descend.Have stimulation to islet cells Radix Ophiopogonis, and blood glucose is descended, and the treatment senile diabetes is had significant curative effect.Radix Ophiopogonis, decoct can significantly improve the laboratory animal hypoxia-bearing capability, increased coronary flow, and myocardial ischemia is had obvious protective effect, and can arrhythmia and improve myocardial contraction.Radix Ophiopogonis, decoct had certain calmness, resisted the effect of fainting of plunderring.Radix Ophiopogonis, decoct was also to Staphylococcus albus, escherichia coli, and various pathogens such as Bacillus typhi have remarkable inhibitory action.In addition, Radix Ophiopogonis water, alcohol extract, but the generation of enhancing antibody and prolong its immunologic function.
The pharmacological action of Gypsum Fibrosum: Gypsum Fibrosum has certain refrigeration function to the artificial fever animal, can alleviate its unusual " thirsty " state, and the Baihu Jia Renshen Tang has the obvious functions of blood sugar effect, can reduce the blood sugar level of alloxan diabetes rat.This side only forms in medicine that there are blood sugar reducing function Radix Scrophulariae, Rhizoma Anemarrhenae list time spent, but Radix Scrophulariae compatibility Gypsum Fibrosum, or the Rhizoma Anemarrhenae when joining Gypsum Fibrosum its hypoglycemic activity all strengthen, Radix Scrophulariae, Rhizoma Anemarrhenae compatibility then blood sugar reducing function weaken on the contrary, the Radix Scrophulariae consumption is big more, acts on weak more.If but in Radix Scrophulariae, Rhizoma Anemarrhenae compatibility, add Gypsum Fibrosum, and the blood sugar reducing function that has been weakened is recovered, and strengthen because of the Gypsum Fibrosum consumption increases blood sugar reducing function within the specific limits, show that seemingly Gypsum Fibrosum plays a kind of special mediation effect here.Gypsum Fibrosum can be strengthened the isolated rabbit pulmonary alveolar macrophage to Staphylococcus albus, and the phagocytic activity of gold colloidal, and can promote the phagocyte maturation.Gypsum Fibrosum also has diuresis, effects such as function of gallbladder promoting.
The pharmacological action of Radix Puerariae: Radix Puerariae decoct, pure preserved material, total flavones, daiazi, puerarin all can resist the acute myocardial ischemia that pituitrin causes.Radix Puerariae total flavones can be expanded coronary vasodilator and cerebrovascular, and coronary blood flow increasing and cerebral blood flow reduce myocardial oxygen consumption, increase the oxygen supply.Radix Puerariae is blood vessel dilating directly, Peripheral resistance is descended, and obvious hypotensive effect is arranged, and can better alleviate " item is tight " symptom of hypertensive patient.Puerarin energy microcirculation improvement improves local little blood flow, suppresses platelet aggregation.Puerarin can effectively reduce the excessive release of patients with hypertension Endothelin (ET), corrects thromboxane A2-prostaglandin I in the circulation
2(TXA
2-PGI
2) dysequilibrium, significantly improve patient's clinical symptoms.Radix Puerariae has beta receptor retardation widely.The Radix Puerariae decoct has the trivial solution heat effect, and slight hypoglycemic activity is arranged.May there be albumen nonenzymatic glycosylation inhibitor composition in the Radix Puerariae, diabetic peripheral neuropathy is had therapeutical effect.
The present invention is based on secret prescription handed down in the family from generation to generation, with reference to the modern pharmacological research achievement, use and make through research for many years and clinical experience, be used for blood sugar lowering, blood circulation promoting, helping the generation and the development of delaying complications of diabetes and reduce the infringement of complication to the patient, is to cure the diabetes specific drug, and cheap.Said herbal medicine is carried out packing after the compositions porphyrize that the science compatibility forms sieves.
The specific embodiment
Embodiment one: a kind of Chinese medicine composition for the treatment of diabetes, it is made up of the following weight proportion raw material: Radix Trichosanthis 13, the Radix Rehmanniae 18, Radix Scrophulariae 13, the Rhizoma Anemarrhenae 13, Fructus Corni 13, the Radix Astragali 28, Rhizoma Dioscoreae 18, Rhizoma Atractylodis 13, Semen Coicis 18, Radix Ophiopogonis 10, Gypsum Fibrosum 28, Radix Puerariae 18.
Embodiment two: a kind of Chinese medicine composition for the treatment of diabetes, it is made up of the following weight proportion raw material: Radix Trichosanthis 17, the Radix Rehmanniae 22, Radix Scrophulariae 17, the Rhizoma Anemarrhenae 17, Fructus Corni 17, the Radix Astragali 32, Rhizoma Dioscoreae 22, Rhizoma Atractylodis 17, Semen Coicis 22, Radix Ophiopogonis 14, Gypsum Fibrosum 32, Radix Puerariae 22.
Embodiment three: a kind of Chinese medicine composition for the treatment of diabetes, it is made up of the following weight proportion raw material: Radix Trichosanthis 15, the Radix Rehmanniae 20, Radix Scrophulariae 15, the Rhizoma Anemarrhenae 15, Fructus Corni 15, the Radix Astragali 30, Rhizoma Dioscoreae 20, Rhizoma Atractylodis 15, Semen Coicis 20, Radix Ophiopogonis 12, Gypsum Fibrosum 30, Radix Puerariae 20.
Claims (3)
1. Chinese medicine composition for the treatment of diabetes, it is characterized in that: it is made up of the following weight proportion raw material: Radix Trichosanthis 13, the Radix Rehmanniae 18, Radix Scrophulariae 13, the Rhizoma Anemarrhenae 13, Fructus Corni 13, the Radix Astragali 28, Rhizoma Dioscoreae 18, Rhizoma Atractylodis 13, Semen Coicis 18, Radix Ophiopogonis 10, Gypsum Fibrosum 28, Radix Puerariae 18.
2. a kind of Chinese medicine composition for the treatment of diabetes according to claim 1, it is characterized in that: it is made up of the following weight proportion raw material: Radix Trichosanthis 17, the Radix Rehmanniae 22, Radix Scrophulariae 17, the Rhizoma Anemarrhenae 17, Fructus Corni 17, the Radix Astragali 32, Rhizoma Dioscoreae 22, Rhizoma Atractylodis 17, Semen Coicis 22, Radix Ophiopogonis 14, Gypsum Fibrosum 32, Radix Puerariae 22.
3. a kind of Chinese medicine composition for the treatment of diabetes according to claim 1, it is characterized in that: it is made up of the following weight proportion raw material: Radix Trichosanthis 15, the Radix Rehmanniae 20, Radix Scrophulariae 15, the Rhizoma Anemarrhenae 15, Fructus Corni 15, the Radix Astragali 30, Rhizoma Dioscoreae 20, Rhizoma Atractylodis 15, Semen Coicis 20, Radix Ophiopogonis 12, Gypsum Fibrosum 30, Radix Puerariae 20.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102343026A (en) * | 2011-09-30 | 2012-02-08 | 蚌埠丰原涂山制药有限公司 | Traditional Chinese medicine composition for treating diabetes and preparation method thereof |
| CN102755568A (en) * | 2012-07-27 | 2012-10-31 | 贵州文旺薏苡仁开发有限责任公司 | Health-care product for assisting in decreasing blood sugar and preparation method thereof |
| CN103495020A (en) * | 2013-10-16 | 2014-01-08 | 刘运波 | Traditional Chinese medicine for treating diabetes |
| CN104398771A (en) * | 2014-12-16 | 2015-03-11 | 天圣制药集团股份有限公司 | Traditional Chinese medicine composition for treating diabetes |
| CN104784472A (en) * | 2014-07-10 | 2015-07-22 | 侯艮仓 | Traditional Chinese medicine composition for decreasing blood sugar to treat diabetes |
| CN105687604A (en) * | 2014-11-27 | 2016-06-22 | 韦健宁 | Chinese medicinal composition for treatment of diabetes |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1557378A (en) * | 2004-02-07 | 2004-12-29 | 李炳全 | Medicine for treating diabetes |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1557378A (en) * | 2004-02-07 | 2004-12-29 | 李炳全 | Medicine for treating diabetes |
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| Title |
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| 高彦彬: "糖尿病患者的中药治疗", 《家庭中医药》 * |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102343026A (en) * | 2011-09-30 | 2012-02-08 | 蚌埠丰原涂山制药有限公司 | Traditional Chinese medicine composition for treating diabetes and preparation method thereof |
| CN102343026B (en) * | 2011-09-30 | 2013-06-12 | 蚌埠丰原涂山制药有限公司 | Traditional Chinese medicine composition for treating diabetes and preparation method thereof |
| CN102755568A (en) * | 2012-07-27 | 2012-10-31 | 贵州文旺薏苡仁开发有限责任公司 | Health-care product for assisting in decreasing blood sugar and preparation method thereof |
| CN102755568B (en) * | 2012-07-27 | 2014-06-25 | 贵州文旺薏苡仁开发有限责任公司 | Health-care product for assisting in decreasing blood sugar and preparation method thereof |
| CN103495020A (en) * | 2013-10-16 | 2014-01-08 | 刘运波 | Traditional Chinese medicine for treating diabetes |
| CN103495020B (en) * | 2013-10-16 | 2015-04-15 | 刘运波 | Traditional Chinese medicine for treating diabetes |
| CN104784472A (en) * | 2014-07-10 | 2015-07-22 | 侯艮仓 | Traditional Chinese medicine composition for decreasing blood sugar to treat diabetes |
| CN105687604A (en) * | 2014-11-27 | 2016-06-22 | 韦健宁 | Chinese medicinal composition for treatment of diabetes |
| CN104398771A (en) * | 2014-12-16 | 2015-03-11 | 天圣制药集团股份有限公司 | Traditional Chinese medicine composition for treating diabetes |
| CN104398771B (en) * | 2014-12-16 | 2017-11-10 | 天圣制药集团股份有限公司 | A kind of Chinese medicine composition for treating diabetes |
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Application publication date: 20110119 |