CN103099886A - Soft capsule helpful for improving intestinal and gastric functions and preparation method thereof - Google Patents

Abstract

The invention mainly relates to a soft capsule helpful for improving intestinal and gastric functions and a preparation method thereof. The soft capsule helpful for improving the intestinal and gastric functions is characterized by consisting of the following raw materials in parts by weight: 360-520 parts of linseed oil, 10-30 parts of an angelica extract, 10-30 parts of a prepared rehmannia root extract, 10-30 parts of a polygonum multiflorum extract, 10-30 parts of a cassia seed extract, 10-30 parts of an ophiopogon root extract, 10-30 parts of a rhizoma polygonati extract, 10-30 parts of a peach kernel extract and 10-30 parts of a bunge cherry seed extract. The soft capsule disclosed by the invention, guided by theories of traditional Chinese medicine and based on modern research achievements of the traditional Chinese medicine, is careful in material selection, strict in composition and reasonable in combination, so that the composition follows principles of nourishing Yin and supplementing blood, promoting blood circulation and dissolving stasis, nourishing Yin and moistening dryness, and soothing liver and gallbladder. Angelica functions as regulating menstruation and relieving pain, moistening intestines, replenishing blood and promoting blood circulation; prepared rehmannia root is used for nourishing Yin and supplementing blood, replenishing vital essence and filling marrow; polygonum multiflorum can relieve toxicity and dissolve carbuncle, and relax bowel; cassia seed functions as clearing away liver fire, expelling wind damp, tonifying kidney and improving eyesight; ophiopogon root is capable of nourishing Yin and promoting secretion of saliva, moistening lung and clearing away heart fire; bunge cherry seed can moisten dryness and intestines, depress Qi and clear damp; and rhizoma polygonati can tonify Qi and nourish Yin, strengthen spleen and tonify kidney.

Description

Help soft capsule that improves gastrointestinal function and preparation method thereof

Technical field:

The present invention relates generally to and helps soft capsule that improves gastrointestinal function and preparation method thereof.

Background technology:

At present, help to improve the formula of gastrointestinal function, existing relevant report.Existing formula is considered to rush down lower function mostly, and it is main mainly with Radix Et Rhizoma Rhei, Semen Cassiae etc., the raw material of discharge function being arranged, and seldom considers to cause the underlying causes of constipation, and effect is relatively poor, or for the moment effectively, but restore to the original state again after withdrawing.And the Chinese crude drug that contains the Anthraquinones composition has the effect of astringing intestine to stop diarrhea more, and after long-term taking, discharge function reduces, and the constipation meeting increases the weight of.

This invention has been studied the mechanism of constipation, thinks that constipation is too greasy or take in the food of the higher fatty acid high protein of high heat such as red meat except diet, and following reason is still arranged: heat symptom-complex appears in human body, as liver-fire, stomach-fire, lung-heat etc.; The deficiency of YIN that hyperactivity of fire caused by deficiency of YIN, many reasons cause, oral ulcer etc. inflamed eyes, toothache, otitis media, aphtha of the mouth and tongue appear, in hyperactivity of deficient fire; The decline of middle-aged and elderly people physical function, depletion of body fluid causing lack of blood, gastrointestinal gradually lose lubricated and wriggling function, make difficult defecation.

The present invention is directed to the underlying causes prescription of constipation, though Radix Polygoni Multiflori, Semen Cassiae contain anthraquinones, discharge function is lasting gently than Radix Et Rhizoma Rhei, Aloe, and has that hepatoprotective makes eye bright, the anti-ageing function of waiting for a long time; Radix Angelicae Sinensis, Radix Rehmanniae Preparata, Rhizoma Polygonati, Radix Ophiopogonis, Semen Persicae blood-supplementing blood-nourishing, enriching yin and nourishing kidney are invigorated blood circulation and are moisturized the situation of improving depletion of body fluid causing lack of blood, but increase body immunity and resistance against diseases.Energy and blood of human body is full, Metabolism of Normal, and constipation must be delayed, and in the side, each medicine all has the effect of loosening bowel to relieve constipation, but is not under rushing down merely, but fundamentally solves the obstipation of the problem of constipation, particularly middle-aged and elderly people.

Summary of the invention:

The object of the invention is to avoid the deficiencies in the prior art part and a kind of soft capsule of improving gastrointestinal function and preparation method thereof that helps, the problem that exists to solve prior art be provided.

Purpose of the present invention can be by realizing by the following technical solutions: a kind of soft capsule that helps to improve gastrointestinal function, its main feature are the raw materials that includes following weight portion: siritch 360-520 weight portion, Radix Angelicae Sinensis extract 10-30 weight portion, Radix Rehmanniae Preparata extract 10-30 weight portion;

The described soft capsule that helps to improve gastrointestinal function also includes the raw material of following weight portion: Radix Polygoni Multiflori extract 10-30 weight portion, Semen Cassiae extract 10-30 weight portion, Radix Ophiopogonis extract 10-30 weight portion;

The described soft capsule that helps to improve gastrointestinal function also includes the raw material of following weight portion: Rhizoma Polygonati extract 10-30 weight portion, Semen Persicae extract 10-30 weight portion, Semen Pruni extract 10-30 weight portion;

A kind of preparation method that helps to improve the soft capsule of gastrointestinal function, its main feature is, comprises the steps:

(1) raw material preparation

Radix Angelicae Sinensis, Radix Rehmanniae Preparata, Radix Polygoni Multiflori, Semen Cassiae, Radix Ophiopogonis, Semen Persicae, Semen Pruni, Rhizoma Polygonati are carried out respectively selected, rinsing twice is drenched and to be anhydrated minute; Be 60～80 ℃ of oven dry 1.5-2 hour in temperature, making its moisture is 5-6%, after coarse pulverization granularity be 5-50mm to add water be 8 times of material, lixiviate 2-8 hour, extract 2 times; Twice filtrate merged, concentrated, be 60-80 ℃ of oven dry 1.5-2 hour in temperature, make its moisture 5-6% of being divided into; Pulverize, sieve, granularity is 0.1-0.5mm, is the Chinese medicine extract fine powder.

The selected slag of removing of flaxseed; Adopt pressafiner that selected flaxseed is squeezed; Again siritch is removed slag, add water and regulate pH value 5.5-6.5, at water temperature 55-65 ℃, fully stir, remove moisture after then precipitating two hours namely to get the refine siritch;

(2) with siritch, the extracts such as Radix Polygoni Multiflori, Radix Angelicae Sinensis, Radix Rehmanniae Preparata, Semen Cassiae, Rhizoma Polygonati, Radix Ophiopogonis, Semen Persicae, Semen Pruni mix in proportion;

(3) press 0.6g/ grain dress soft capsule after mix homogeneously;

(4) sterilization bottling, vanning.

1, the invention has the beneficial effects as follows: the method screening raw material that our section of use emulates the advanced, rigorous prescription, the check of the various raw materials of process and chemical analysis thereof, function, the total analysis result of the present invention of cash is as follows:

(1) Radix Rehmanniae Preparata:

Radix Rehmanniae Preparata Shudihuang is the tuber of scrophulariaceae rehmannia glutinosa plant R ehmannia glutinosa (Gdertn) Iibosch., concocts through processing to form.Usually through repeatedly steaming solarization, glossy to inside and outside darkish complexion, the quality softness is sticky as adjuvant take wine, Fructus Amomi, Pericarpium Citri Reticulatae; Meridian distribution of property and flavor: sweet, tepor.Return liver, kidney channel.Function cures mainly: nourishing YIN and supplementing blood, beneficial essence is filled out marrow.Be used for the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, the night sweat seminal emission, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, metrostaxis, dizzy, tinnitus, early whitening of beard and hair.

contain Herba Leonuri glycoside (leonuride), aucubin (aucubin), catalpol (catalpol), rehmannioside (rehmannioside) A, B, C, D, U.S. profit appropriate pair of glycoside (melittoside), rehmanin (rehma-glutin) A, D, the smelly formaldehyde glycoside of Radix Rehmanniae chlorination (glutinoside), burnt rehmanin (jioglutin) A, B, C, burnt Radix Rehmanniae lactone (jioglutolide), burnt jiofuran (jiofuran), , the bitter glycoside unit of Radix Rehmanniae (rehmapicrogenin), separately contain trihydroxy-alpha, beta-lonone (trihydroxy-β-lonone), dihydroxy-alpha, beta-lonone (dihydroxy-p-lonone), aeginetic acid (aegineticacid), 5-hydroxyl aeginetic acid (sec-hydroxyaeginetic acid), succinic acid (succinic acid), 5-pidolic acid (5-oxoproline), 5-HMFA (5-hydroxymethylfuroic acid), uracil (uracil), uridine (uridine) etc.separate from ligroin extraction again and obtain: linoleic acid (linoleic acid), Palmic acid (palmitic acid), stearic acid (stearic acid), arachidic acid (arachidic acid), behenic acid (be-henic acid), pentadecanoic acid (pentadecanoic acid), palmitoleic acid (palmitoleic acid), myristic acid (myristic acid), 19 carbonic acid (nonadecanOic acid), 20-carbonic acid (heneicosanoic acid), 17 carbonic acid (margaric acid).

Dietary function: sweet in the mouth, slightly warm in nature.The YIN nourishing of enriching blood, strengthening and nourishing marrow and essence.Be used for blood deficiency, shallow complexion, dizzy cardiopalmus; Blood deficiency, menoxenia, metrorrhagia is lost blood; Yin asthenia generating intrinsic heat, osteopyrexia and fever, night sweat; Deficiency of the kidney yin, the xerostomia of quenching one's thirst; Liver and kidney two void, asthenia of essence and blood, soreness of the waist and knees, vertigo and tinnitus, early whitening of beard and hair.Alone, or with Radix Angelicae Sinensis compatibility stewed chicken, be used for syndrome of deficiency of blood or menoxenia; Join the Radix Astragali, Rhizoma Dioscoreae, Radix Asparagi, fry in shallow oil the soup drink, be used for quenching one's thirst (diabetes); Join Fructus Lycii, Semen Cuscutae, Fructus Rubi infusing drugs in wine, anti-ageing in order to tonify deficiency.Available 15～30g on the one.

Tcm clinical practice confirms, hyperactivity of fire caused by deficiency of YIN be acne morbidity this, deficiency of kidney yin, the liver failing to maintain the normal flow of QI make woman's disharmony of Chong and Conception Channels, and cause acne and send out with menstrual synchrony.The Rehmannia glutinosa Libosch Water decoct can obviously reduce the excretion of mouse retention albumen, improves the case variations such as glomerular epithelium cell podocytic process fusion.Thereby kidney tonifying YIN nourishing.The Rehmannia glutinosa Libosch Water decoct all has inhibitory action to funguses such as palpus skin ulcer Xian bacterium, the little sporeformer of Gypsum Fibrosum sample, the little sporeformer of hair shape, can effectively suppress the Sino-German anaerobe of acne, coryneform breeding.

Modern study:

1. chemical composition: this product contains catalpol, rehmanin, mannitol, retinoid material, saccharide and aminoacid etc.

2. pharmacological action: Radix Rehmanniae can be resisted the decline of taking continuously plasma corticosterone concentration after dexamethasone, and can prevent Adrenal cortex atrophy.Radix Rehmanniae decoct gavage can significantly reduce the ascorbic content of Rat Adrenal.As seen Radix Rehmanniae has the antagonism dexamethasone to the inhibitory action of Pituitary Adrenal cortex system, and can promote the synthetic of adrenocortical hormone.LIUWEI DIHUANG TANG has obvious blood pressure lowering, improves renal function, reduces the effect of case fatality rate to the rat experiment renal hypertension.LIUWEI DIHUANG TANG is obviously resisted the effect that N-nitroso-group propylhomoserin second fat brings out the mice model of forestomach squamous cell cancer.

3. clinical research: Radix Rehmanniae Preparata decoct treatment hypertension, blood pressure, serum cholesterol and triglyceride all have decline, and rheoencephalogram and electrocardiogram also make moderate progress (Radix Rehmanniae Preparata is concocted with wine scientific research achievements identification book whether, 1980.6).Be 84% with the sub-rehmannia-root oral liquid treatment of compound recipe five male infertility total effective rate.

(2) Radix Angelicae Sinensis:

Enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.Be used for the dryness of the intestine constipation, blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, rheumatic arthralgia, injury from falling down, ulcer sores.The Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.Be used for the amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.

The effect of Radix Angelicae Sinensis:

1. to the effect of uterine smooth muscle: the effect Fuhua of isolated uterine is equaled to report in 1954 that the Minxian County, Gansu contained at that time excited and suppressed two kinds of compositions of uterine smooth muscle, have amphicheirality's effect.Suppress composition and be mainly volatile oil, excited composition is water solublity or pure dissolubility and the insoluble nonvolatile matter of ether.Also report of Wu Baojie etc. in the same year, Radix Angelicae Sinensis to isolated uterine with act on differently in the body uterus, decoct or ethanol extract are preponderated (in the body uterus, mainly being excitation) to the isolated uterine inhibitory action.The next year experiment of skin west duckweed shows, steeping in wine cream and aqueous extract are inhibition in medication first, rinse recover after again administration be excitation.Studies show that further Radix Angelicae Sinensis volatile oil all has direct repression to the animal unpregnancies such as rabbit, Cavia porcellus, mice, rat, Canis familiaris L., early pregnancy, late isolated uterine pregnant, puerperal, rhythmicity is shunk diminish gradually to disappearance, be the state of relaxing.And the uterine contraction that causes such as antagonism pituitrin, histamine, epinephrine and acetylcholine.Danggui extract, danggui liujin gao is mainly excitement, and heavy dose is inhibitory action sometimes.Proof po or iv ferulic acid and tetramethylpyazine mixed liquor suppress to have potentiation to rat uterine contraction in place.

2. to the effect of cardiovascular system: the reports such as Lan Dahe, Isolated Toad Heart perfusion experiment show, in Radix Angelicae Sinensis decoct or root and leaf, contained volatile oil can make the myocardial contraction frequency obviously be suppressed.Zhang Shufang etc. show at body Bufo siccus heart majority dissociation to occur with stomach wall iv administration, and atrial contractility obviously weakens, recover gradually later on, and frequency deceleration, but ventricular systole power strengthens on the contrary.Wei Lianji report, danggui extract, danggui liujin gao can make rabbit isolated atria prolonged refractory period, and anesthetized cat and dog atrial fibrillation that acetylcholine or electric current are caused have therapeutical effect, and the effective ingredient of above-mentioned quinidine-like action mainly is present in ether extract.According to another Academy of Traditional Chinese Medicine, Jiangsu Province report, danggui extract, danggui liujin gao and ether extract can reduce myocardial excitability, make the refractory stage significant prolongation.

1. antiarrhythmic effect

2. on the impact of coronary flow and myocardial oxygen consumption

3. on the impact of blood vessel, blood pressure and organic blood flow volume

4. blood fat reducing and anti-experimental character Atherosclerosis

Separate the active component 8-methoxyl group psoralen (1) that increases blood flow that has obtain from Radix Angelicae Sinensis, after taking in vivo almost all by metabolism.Infer thus, the effect of compound 1 increase blood flow is relevant with its metabolite.This time relatively inquire into vein and given after compound 1 and metabolite thereof impact on the mouse peripheral blood flow.Method and result: after the mice iv that betamethasone (1.6mg/kg, im) is brought out syndrome of blood stasis gives compound 1 and metabolite thereof, detect the peripheral blood flow at back.

(3) Radix Polygoni Multiflori:

Detoxifcation, eliminating carbuncle, loosening bowel to relieve constipation.Be used for the scrofula carbuncle sore, rubella pruritus, dryness of the intestine constipation; Hyperlipidemia.

1, bone light air disease (lumbocrural pain, pruritus all over, row step difficulty).With each jin of Radix Polygoni Multiflori (take the person that has the decorative pattern as best), Radix Achyranthis Bidentatae, to steep for seven nights in the wine that coexisted, taking-up is dried, and mashes, and adds jujube pulp and becomes a ball, and is as large in Firmiana simplex seed.Every 30 to 50 balls that take.Hollow clothes, wine send down.

2, flesh side have a pain (do not know pain wherein).With Radix Polygoni Multiflori end, Sucus Zingberis furnishing cream is coated with to be put on the skin, put on the skin to encase with cloth afterwards, with fire baking sole press by.

3, from apogee sweating.With the Radix Polygoni Multiflori end, transfer saliva, on the envelope umbilicus.

4, discharging fresh blood stool.With two liang of what road crows, grind and be the end.Every two money that take, taking medicine before meal, rice water send down.

5, broken blood trouble goes out.Apply namely with the Radix Polygoni Multiflori end and stop.Specially good effect is arranged.

6, scrofula tuberculosis (or broken or broken, the former all can control down to breast), clean with the Radix Polygoni Multiflori root, and give birth to and chew every day, and get leaf and mash and be coated with the affected part.

7, carbuncle skin infection.Quantity-unlimiting with Radix Polygoni Multiflori, torture on mild and heavy respiration, with wine equivalent, then after being fried open several times, deposit wine, drink at any time; The slag of getting it filled dries, and grinds to be the end, boils a face furnishing ball with wine, and is as large in Firmiana simplex seed.Every 30 balls that take, hollow clothes, heat wine send down.After recovering, but the medicine informal dress.

8, large scrofula caused by pathogenic wind disease.With one jin of Radix Polygoni Multiflori (with the large and person that has the decorative pattern for well), in the bubble washing water of rice seven days, repeatedly steam, shine for several times, add four liang of linum, then steaming solarization again, grind and be the end, every two money that take, wine send down, take secondary in one day.

9, scabies.With Radix Polygoni Multiflori, district's leaf decile, the bathing of decocting thick soup, can alleviate pain, granulation promoting meat.Fry in shallow oil the soup bathing with Caulis Polygoni Multiflori, leaf, also effective.

The effect of Radix Polygoni Multiflori:

1. the pharmacological action relevant to effect:

1. promote hemopoietic function: mouse subcutaneous injection Radix Polygoni Multiflori liquid 0.2g, every day 2 times, successive administration 3 days can make a productive rate that is CFU-GM apparently higher than the normal saline matched group.Mouse peritoneal injection Radix Polygoni Multiflori extracting solution 50mg/kg successive administration 3 days can make marrow hemopoietic stem cells obviously increase, and also can significantly improve mice grain one monosystem CFU-GM generation rate, and bone marrow CFU-E value is obviously raise.

2. strengthen immunologic function: the Aged Mice spleen that Radix Polygoni Multiflori causes meticortelone and cyclophosphamide, the thymus inhibition changes that obvious antagonism is arranged, and the phagocytic rate of splenic macrophage and phagocytic index are obviously improved.The Radix Polygoni Multiflori ethanol extract of feeding can obviously improve the injury repairing ability of senile rat periphery lymphocyte DNA.Mouse gavaging Radix Polygoni Multiflori Preparata 6g/kg, successive administration 7 days can obviously improve the phagocytic activity of peritoneal macrophage, and the phagocytic index that meticortelone is caused descends, and obvious antagonism is arranged.

3. blood fat reducing and atherosclerosis: hyperlipidemia rats gavage every day Radix Polygoni Multiflori 4g/kg, continuous 10 days, can reduce the content of rat blood serum T-CHOL (TC) and serum triglycerides (TG) more significantly.For the hyperlipemia Carnis Coturnicis japonicae, continuously 4 weeks of the gavage Radix Polygoni Multiflori, can obviously reduce serum TC content and improve HDL/TC ratio.Separately experiment showed, hyperlipemia and Atherosclerosis Model rabbit, Radix Polygoni Multiflori gavage 7 days can not only reduce TC content, can also alleviate atheromatous plaque and form.Radix Polygoni Multiflori water extraction liquid 32g/kg fed mice 1 month, can obviously improve the HDL-C level.Radix Polygoni Multiflori is incorporated into and feeds rat in feedstuff, after 90 days, and the HDL-C that also can obviously raise, and TG and TC have obvious inhibitory action without significant change to beta Lipoprotein.The Radix Polygoni Multiflori alcohol extract is given quick Atherosclerotic Quail gavage, and in continuous 6 weeks, blood plasma HDL-C/TC ratio significantly raises, and heavy dose of group of effect is more remarkable.Each administration group all has the atherosclerotic effect that delays.The effective ingredient of Radix Polygoni Multiflori blood fat reducing and anti-cholesterol effect comprises Anthraquinones, hexichol ene compound and lecithin etc.

4. protect the liver: the contained hexichol ene compound of Radix Polygoni Multiflori is to rat fat liver and liver function injury due to the peroxidating Semen Maydis oil, the rising of liver lipid peroxide, serum glutamic pyruvic transminase and glutamic oxaloacetic transaminase, GOT rising etc. all have obvious antagonism, and serum free fatty acid and liver LPO are descended.In the external rat liver microsomal lipid peroxidation that caused by ADP, NADPH of suppressing.Radix Polygoni Multiflori increases the hepatic glycogen effect in addition.Due to Radix Polygoni Multiflori, decoction of black soybean Radix Polygoni Multiflori Preparata and steamed Radix Polygoni Multiflori decocting liquid Dichlorodiphenyl Acetate prednisone, liver fat accumulation has antagonism, can reduce the hepatomegaly that CCl4 causes, the heavy coefficient of liver is reduced.

5. slow down aging, modern investigation have vitamin E to prevent wrinkle regeneration: Radix Polygoni Multiflori decocting liquid is fed Aged Mice or young mice, can make that in the brain regulating liver-QI, protein content obviously increases, and improves old body DNA repair ability.The ethanol extract of Radix Polygoni Multiflori and water extract can increase senile rat thymus plasmosin and nucleic acid content to some extent.The Radix Polygoni Multiflori delaying senility function is relevant with antioxidation.Aged Mice gavages the Radix Polygoni Multiflori water drug-decocting concentrating liquid, can obviously strengthen SOD activity in blood.The process of preparing Chinese medicine has certain influence to Radix Polygoni Multiflori antioxidation, process product and old method processed product all be significantly improved mice whole blood and cerebral tissue SOD active function, and can reduce in mouse core, liver, cerebral tissue and blood in LPO content, the product of giving birth to have no significant effect SOD and LPO.Radix Polygoni Multiflori alcohol extract or water extraction extract all can improve to some extent tissue SOD's content of the senile rat heart, liver, brain and reduce LPO content.

6. the impact of Endocrine: the Radix Polygoni Multiflori water drug-decocting concentrating liquid is given mouse stomach for a long time, and mice adrenal gland weight is obviously increased.Radix Polygoni Multiflori also has the effect of similar adrenal cortex function, to extracing the mice of bilateral adrenal glands, its stress ability is obviously improved, and reduces the freezing mouse death rate that causes.Radix Polygoni Multiflori Preparata has facilitation to the hungry Mouse Liver glycogen accumulation of norepinephrine, and hepatic glycogen is obviously increased.Radix Polygoni Multiflori has certain time-effect relationship to the impact of blood glucose, gives after the oral Radix Polygoni Multiflori decoct of rabbit blood sugar increasing peaking in 30,60 minutes, descends gradually afterwards, and after 6 hours, blood glucose is lower than normally.The rats'liver Insulin receptor INSR has the high-affinity low capacity, and two kinds of receptors of low-affinity high power capacity, and the Aged Mice binding capacity significantly reduces, but affinity is unchanged.Radix Polygoni Multiflori all has no significant effect capacity and two parameters of affinity.

7. loosening bowel to relieve constipation: Radix Polygoni Multiflori is given birth to use, and functions of loosening bowel relieving constipation is strong, and its effective ingredient chrysophanol can promote the motion of animal intestinal tube.After part hyperlipemia patient took, times of defecation increase and diarrhoea phenomenon appearred.

2. other pharmacological actions: report was once arranged, various processed product (the Radix Polygoni Multifloris of Radix Polygoni Multiflori, wine steams the Radix Polygoni Multiflori, the black juice steam Radix Polygoni Multiflori, the steamed Radix Polygoni Multiflori) decocting liquid is outer to staphylococcus aureus, Staphylococcus albus, shigella flexneri, sonne bacillus, Bacillus typhi 901, Salmonella paratyphi is from diphtheria corynebacterium, beta hemolytic streptococcuss etc. all have in various degree. inhibitory action, wherein the effect of Radix Polygoni Multiflori decoct anti-Staphylococcus aureus is stronger than other processed products, the Radix Polygoni Multiflori Preparata water decoction is to Staphylococcus albus, wine steams Radix Polygoni Multiflori water decoction and Radix Rehmanniae juice steaming Radix Polygoni Multiflori water decoction is stronger than other Radixs Polygoni Multiflori to the inhibitory action of diphtheria corynebacterium.The Radix Polygoni Multiflori infected by influenza has certain inhibitory action.In addition, Radix Polygoni Multiflori also has decreased heart rate, coronary artery dilating, the effect such as resist myocardial ischemia.

In sum, with Radix Polygoni Multiflori invigorating the liver and kidney, benefiting essence-blood, black beard and hair, the pharmacological action that the bone and muscle strengthening effect is relevant is to promote hemopoietic function, improves body's immunity, blood fat reducing, atherosclerosis, protect the liver, slow down aging affects endocrine function, the effects such as loosening bowel to relieve constipation.The material base of Radix Polygoni Multiflori efficacy effect is mainly the compositions such as phospholipid, Anthraquinones, glucose glycoside.

(4) Semen Cassiae:

Dry mature seed for pulse family annual herb plant Semen Cassiae or little Semen Cassiae.Semen Cassiae is named also that Semen Cassiae, sheep are bright, Cornu Caprae seu Ovis, Horse hoof Semen Cassiae, go back gb 1, bullshit bean, false Semen phaseoli radiati, Horse hoof, Herba Senecionis Scandentis, celery certainly, bright, the blue bean of pig dung of swordweed, wild Semen phaseoli radiati, Os Sus domestica, spire Herba crotalariae mucronatae, night rock, sheep tail bean.Bitter in the mouth, sweet and cool in nature has the functions such as clearing away liver-fire, wind-damp dispelling, tonifying kidney and improving eyesight.

The effect of Semen Cassiae:

1, the infusion of hypotensive activity Semen Cassiae, ferment-infusion, pure immersion all has hypotensive effect to anesthetized dog, cat, rabbit etc.; But preserved material is not obvious to the anesthetized rabbit hypotensive effect, and with 5 milliliters of Semen Cassiae tinctures, blood pressure lowering is more obvious, and the persistent period is longer, with the quiet notes of commensurability rare alcohol, but also blood pressure lowering (but immediate recovery).Isolated Toad Heart there is inhibitory action; Blood vessel is had contraction (lower limb perfusion), and in chronic experiment, decoct gram every days 2 (crude drug)/kilogram is without hypotensive effect.

2, the alcohol extract of antibacterial action seed all has inhibitory action to staphylococcus, diphtheria corynebacterium and typhoid fever, paratyphoid fever, escherichia coli etc., water extract is invalid, and water logging agent (1: 4) has in various degree inhibitory action to some dermatophytes in test tube.Contain chrysophanol, but amount is few, may be slight with it antibiotic, discharge function is relevant.

The effect of Semen Cassiae:

Semen Cassiae has multiple medical care effect.For example, treatment hypertension, desirable appropriate Semen Cassiae is smash into powder after parching to brown, and sugaring takes after mixing it with hot water, each 3 grams, every day 3 times; Or be decocted in water for oral dose together with Semen Cassiae 15 grams, Spica Prunellae 9 grams.The treatment hyperlipemia, desirable Semen Cassiae, each 15 grams of Rhizoma Alismatis, Radix Paeoniae Rubra 12 grams, Ganoderma, each 9 grams of Fructus Crataegi, divide to be decocted in water for oral dose for 2 times at 1 dose of every day; Or get living Semen Cassiae 30 grams, Fructus Crataegi, each 20 grams of Radix Puerariae are decocted in water for oral dose.Treatment constipation or habitual constipation, desirable Semen Cassiae (parched) 10-15 gram, crystal sugar 10 grams, boiling water brew when tea-drinking use, and 1 dose of every day, every dose is steeped 3 times; Or the Semen Cassiae (parched) 10-15 gram decocting of the pulverizing of learning from else's experience to entering 20-30 gram Mel and stirring evenly, takes 1 dose or sub-service sooner or later about 10 minutes every night.For senility habitual constipation, also desirable single Semen Cassiae (parched) or Semen Cassiae 15 grams smashed, directly make tea and drink, until tea is colourless.For old people's deficiency of YIN insufficiency of blood person, can add Fructus Lycii 9 grams, Flos Chrysanthemi, each 5 grams of the Radix Rehmanniae together to be taken after being infused in hot water or decoction; If the old people has the disease of the deficiency of vital energy, should add Radix Ginseng 3 grams with being taken after being infused in hot water or decoction.The old people drinks Semen Cassiae tea, not only helps free movement of the bowels, can also play make eye bright, the health care such as blood pressure lowering, accent fat.It should be noted that the deficiency of vital energy seriously reaches the loose stool person and should not use this product.

Side effect:

The Semen Cassiae cold nature, the people of easily diarrhoea, diarrhoea, stomachache should not drink this tea.It should be noted that: having loose bowels is cautious use of the Semen Cassiae preparation with the hypotensive.The side effect of its " main wash with watercolours rushes down " must cause conceived women's attention, and current research finds, long-term drink gently causes menstruation irregularis, and is heavy make endometrium undesired, thereby brings out premature labor.

if that it seems from book or others say with Semen Cassiae control myopia words, you are just completely mistaken, this flavor medicine of Semen Cassiae truly have the liver heat removing and eyesight improving effect, so heavy or the more suitable of thermal imagery arranged for liver-fire, for there is no obvious thermal image and defecating rare soft definitely inedible. a lot of medicines that can make eye bright are arranged in Chinese medicine, as Semen Plantaginis, Fructus Lycii, Herba Dendrobii, exempt from SIZI, Concha Margaritifera, Flos Chrysanthemi, Periostracum Cicadae, Concha Haliotidis, Fructus Tribuli, Cortex Fraxinis etc. are innumerable, concrete medication need to be in conjunction with Chinese medical discrimination, can not blindly use without exception, Here it is with Chinese medicine with the difference of Western medicine maximum.

The maximum side effect of Semen Cassiae (Semen Cassiae) may be the relieving constipation laxation, generally do not have other problem, but deficiency of vital energy loose stool person should not use. this medicine truly have effect of weight reducing preferably, the power that also can coordinate Fructus Crataegi to strengthen fat-reducing is also good.

(5) Radix Ophiopogonis:

YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire: be used for dryness of the lung dry cough, the chronic consumptive disease cough, Tianjin wound is thirsty, vexed insomnia, interior-heat is quenched one's thirst, dryness of the intestine constipation, pharyngeal diphtheria; YIN nourishing and the production of body fluid promoting, nourishing the lung to arrest cough: few thirsty, the dry cough spitting of blood in Tianjin that is used for lung-stomach yin deficiency; The cards such as the palpitation and being susceptible to fright of insufficiency of heart-YIN and calentura later stage consumption of body fluid by heat.Join Radix Adenophorae (Radix Glehniae), Bulbus Fritillariae Cirrhosae can be controlled deficiency of lung-YIN dry cough.

The effect of Radix Ophiopogonis:

1, treatment sweating on hot summer days collapse Radix Ophiopogonis, each 10 grams of Radix Ginseng, Fructus Schisandrae Chinensis 6 grams are decocted in water for oral dose, 2 doses of every days.To the sweating collapse, nervous cardiopalmus, hypopiesia, hyperhidrosis is thirsty, and fatigue and asthenia has good effect (editor annotates: this side is created by Jin Dynasty well-known doctor Li Gao, and the side is named as " SHENGMAI SAN ", has made living arteries and veins oral liquid).

2, treatment dryness of the intestine constipation Radix Ophiopogonis, the Radix Rehmanniae, each 15 grams of Radix Scrophulariae.Be decocted in water for oral dose, 1 dose of every day.The effect of loosening bowel to relieve constipation is arranged, be used for being hard and dry.

3, treatment angina pectoris gram Radix Ophiopogonis 45, add decocting and become 30～40 milliliters, and part vic serve on 3～18 months.To allevating angina pectoris, uncomfortable in chest certain effect arranged all.

4, treatment chronic gastritis Radix Ophiopogonis, each 9 grams of the Radix Astragali, Radix Codonopsis, Rhizoma Polygonati Odorati, each 10 grams of Rhizoma Polygonati.Be decocted in water for oral dose, 1 dose of every day, deficiency of stomach-Yin person had good effect.

5, the treatment diabetes are with Rhizoma Phragmitis 30 grams, Radix Ophiopogonis 15 gram, the Rhizoma Anemarrhenae 12 grams.First decocted 30 minutes with little fire, leach decocting liquid, medicinal residues add 500 milliliters, water again, change little fire after big fire is boiled into and decoct 20 minutes, and the extracting juice that removes slag mixes twice fried medicine juice 1 dose of every day.Be used for diabetics thirsty and dry pharynx, polydipsia, vexed not peaceful, or see low grade fever, red tongue, thready and rapid pulse.

6, the acute and chronic bronchitis for the treatment of Radix Ophiopogonis, Radix Asparagi, the Rhizoma Anemarrhenae, Bulbus Fritillariae Cirrhosae, each 9 grams of the Radix Stemonae, Radix Adenophorae (Radix Glehniae) 12 grams.Be decocted in water for oral dose, 1 dose of every day, we are applicable to acute and chronic bronchitis and show as deficiency of YIN cough caused by dryness person.

7, treatment chronic hepatitis, early stage liver cirrhosis egg is 5, Fructus Lycii, Semen arachidis hypogaeae, each 30 grams of thin pork, Radix Ophiopogonis 10 gram, each is appropriate for salt, wet starch, monosodium glutamate.At first with the Semen arachidis hypogaeae fry cooked, Fructus Lycii is cleaned, and enters in boiling water slightly to float.Clean Radix Ophiopogonis, enter in boiling water to boil, be cut into broken end, thin pork is diced, and egg is beaten in bowl, and salt adding a little beat evenly, egg poured in another bowl, water proof cooks, and egg is cut into after cooling granular.Pot is put on very hot oven, and the oil generation of letting off fireworks fries meat cubelets, then pours broken end of egg grain, Fructus Lycii, Radix Ophiopogonis into, fries evenly, puts salt a little and wet starch thicken soup, put the monosodium glutamate seasoning, spreads Semen arachidis hypogaeae.Every day 2 times, the food of going with rice or bread.Effect with nourishing the liver and kidney is applicable to the auxiliary treatment of chronic hepatitis, early stage liver cirrhosis etc.The edible energy of Healthy People health invigorating, diseases prevention is prolonged life.

(6) Semen Persicae:

Dry mature seed for rosaceous plant peach Prunus persica (L.) Batsch or Prunus davidiana Prunus davidiana (Carr.) Franch..Blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation.Be used for amenorrhea, dysmenorrhea ， WEIJIA mass in the abdomen, injury from falling down, dryness of the intestine constipation.Sweet flat, the bitter in the mouth of Semen Persicae enters lung, liver, large intestine channel; Blood stasis removing and clots absorbing is arranged, moisturize the effect of laxation.

The pharmacological action of Semen Persicae

1. blood stasis dispelling blood effect: this product water decoction-alcohol sedimentation liquid can make isolated rabbit ear vein vascular flow increase, and vasodilator effect is arranged.Give the anesthetized dog intra-arterial injection, can increase femoral artery blood flow and reduce vascular resistance, blood vessel wall is had direct dilating effect.This product suppresses blood coagulation and haemolysis in addition.Semen Persicae extract 50mg/ml, in splenic artery, administration can make blood flow acceleration in the anesthetized rat liver microcirculation, and relevant to dosage, and prompting has some improvement to the liver surface microcirculation.

2. antiinflammatory action: this product protein ingredient in two homogeneous protein ingredients, intravenous administration, xylol induced mice ear acute inflammatory reaction all has remarkable inhibitory action.

3. anti-allergic effects: the Semen Persicae water extract can suppress skin-sensitizing antibodies in mice serum and the generation of house mouse spleen hemolytic cell, and its ethanol extraction is oral can suppress the pigment seepage discharge of the PCA reaction (passive cutaneous anaphylaxis, PCA) that antiserum that mice contains skin hypersensitivity antibody causes.

4. other effect: amygdalin has antitussive effect.Fatty oil in Semen Persicae (almond oil) has anthelmintic action, is 80.8% to the anthelminthic effect of pinworm, is 70% to the ascarid effect.

(7) Rhizoma Polygonati:

Rhizoma Polygonati is tonic Chinese medicine commonly used.Be Liliaceae Polygonatum Polygonatum Mill herbaceos perennial, medicinal its rhizome.Kind more than 40 is arranged in the world, and China has more than 30 to plant, and medicinal kind has more than 10 to plant." the Chinese pharmacopoeia regulation as Rhizoma Polygonati medicinal 3 kinds of crude drug in whole are arranged; Rhizoma Polygonati P.sibiricum Redoute, Polygonatum cyrtonema Hua P.cyrtonema Hua and Yunnan Rhizoma Polygonati P.kingianum Coll.et Hemsl.Rhizoma Polygonati is flat, sweet in the mouth; Return spleen, lung, kidney channel; Have the functions such as boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney tonifying; Quench one's thirst for weakness of the spleen and stomach, fatigue and asthenia, xerostomia lack of appetite, deficiency of the lung cough caused by dryness, asthenia of essence and blood, interior-heat.

Rhizoma Polygonati has higher medical value, and the research of relevant Rhizoma Polygonati chemical composition is reported in rising trend recently.So far determined mainly to contain polysaccharide, steroidal saponin, flavone, anthraquinone analog compound, aminoacid isoreactivity composition in Rhizoma Polygonati.

Rhizoma Polygonati is used as medicine with rhizome.Has boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney benefiting functions.Be used for the treatment of weakness of the spleen and stomach, fatigue and asthenia, xerostomia lack of appetite, deficiency of the lung cough caused by dryness, asthenia of essence and blood, the interior-heat disease such as quench one's thirst.Very effective in cure for diabetes.

Chinese medicine is controlled weakness of the spleen and stomach, fatigue and asthenia, and inappetence, cardiopalmus is breathed hard, deficiency of the lung cough caused by dryness, Tianjin wound is thirsty, diabetes, deficiency of kidney essence, soreness of the waist and knees; Tinea pedis is controlled in external; Mongolian medicine smelting physical weakness, cold syndrome of the stomach, dyspepsia, food stagnation, diarrhea due to improper diet, renal cold, spermatorrhea, sexual impotence is had a dizzy spell, cold " Xi Riwu element " disease, lumbago and skelalgia, " Ba Dagan " disease.

The pharmacological action of Rhizoma Polygonati:

1. resisting pathogenic microbes effect: Rhizoma Polygonati has inhibitory action to acid-fast bacilli in vitro, to experimental Cavia porcellus lungy, with decoct lymph enlargement administration again after infecting tulase administration simultaneously and infecting respectively, significant fungistatic effect is all arranged, health status has clear improvement, and its curative effect and isoniazid approach.Bacillus typhi is only had faint inhibitory action, and (antibiotic least concentration is: 500-1000 milligram %).Rhizoma Polygonati alcohol extraction aqueous solution 2% above concentration has in various degree inhibitory action to multiple common pathomycete.Its 1: 10 concentration is to gland, and virus has the slow effect in the court of a feudal ruler, and herpesvirus is had inhibitory action.

2. on the impact of blood glucose: rabbit gavage Rhizoma Polygonati extractum, its blood sugar content increases gradually, then reduces.The blood glucose that Rhizoma Polygonati extractum causes epinephrine is too high is remarkable inhibitory action.

3. antifatigue effect: Rhizoma Polygonati decoct 17.67% a concentration 0.3ml/ lumbar injection can extend the mice swimming time.

4. antioxidation: Rhizoma Polygonati decocting liquid 20% concentration, 13ml/ only feeds drink, and continuous 27 days, make that mouse liver superoxide dismutase (SOD) is active to raise, myocardium lipofuscin content reduces.

5. delaying senility function: Rhizoma Polygonati decoct, 20% concentration soak Folium Mori and feed silkworm, and the effect that extends the silkworm larva phase is arranged.

6. anastalsis: Rhizoma Polygonati methanolic extract 40mg/ only, n-butyl alcohol part 20mg/ only, water layer part 20mg/ only, lumbar injection, to the freezing mouse tail of dry ice-methanol 1 minute, the experiment of back-end crop method showed that anastalsis is arranged, and the mice amount of bleeding is reduced.

7. to Cardiovascular: Rhizoma Polygonati aqueous extract 0.16-0.26g/kg intravenous injection obviously increases the anesthetized dog coronary flow; 1.5g/kg intravenous injection, the Cor Leporis myocardial ischemia that pituitrin is caused has antagonism, and the T ripple that the antagonism pituitrin causes increases, and promotes the T ripple to recover extremely in advance; The 12g/kg lumbar injection can strengthen mice to the tolerance of anoxia.

8. antivirus action: 0.2% drop eye of polygonatum polysaccharide, 6 times/days, or add polygonatum polysaccharide 10mg/kg, 2 times/days, the experimental herpes simplex keratitis of rabbit all there is therapeutical effect.

9. other effect: Rhizoma Polygonati decoct 6g/kg gavage, continuous 10 days, can improve Movse Erythrocyte Membrane Na+, the K+-ATP enzymatic activity.40% 0.3ml/ of Rhizoma Polygonati alcohol extract lumbar injection can improve mouse cardiac muscle, liver, spleen histiocyte DNA to the incorporation efficiency of 3H-TdR.0.5g/ gavage of Rhizoma Polygonati decoct makes mice plasma cAMP, and cGMP content all descends, and it is more to descend with cGMP, so cAMP/cGMP ratio organizes cAMP greater than matched group to spleen, and cGMP content all rises, but cAMP/cGMP ratio is without significant change.

(8) Semen Pruni:

Meridian distribution of property and flavor: hot, bitter, sweet, flat.Return spleen, large intestine, small intestine meridian.Function cures mainly: moisturize laxation, the therapeutic method to keep the adverse QI flowing downwards, diuretic.Be used for intestine-dryness due to consumption of fluid, stagnation of QI due to dyspepsia, abdominal distention constipation, edema, beriberi, dysuria.

Gather and process: the mature fruit of gathering in summer, autumn, remove sarcocarp and nucleocapsid, take out seed, drying.Strongly fragrant Lee's seed contains amygdalin, fatty oil 58.3～74.2%, VFA, thick protein, cellulose, starch, oleic acid.Contain again Saponin 0.96% and plant sterol, vitamin B1.Peel of stem contains tannin 6.3%, cellulose 24.94%.Leaf contains vitamin C 7.30%.The Prunus humilis fruit contains fructose 5.2%.Cerasus triloba contains hydrocyanic acid, and flower contains vitamin C 125.7%.Get Semen Pruni glycoside A from strongly fragrant Lee's fruit, also have vanillic acid, protocatechuic acid, ursolic acid, and flavone compound afzelin, Kaempferitrin, spend more glycoside A and B, spend more glucoside, and confirm that Semen Pruni glycoside A is same compound with spending more glycoside A.It is reported that strongly fragrant Lee's seed contains Semen Pruni glycoside A approximately 0.96%, the seed of Prunus humilis approximately contains 0.74%.Another Prunus humilis fruit contains fructose.

Semen Pruni contains a small amount of cyanogen glycosides, produces hydrocyanic acid after the chance enzyme hydrolysis, and this is its side effect.Its diarrhea inducing composition is the Semen Pruni glycoside.Laboratory animal there is strong discharge function.The similar Sennosides of its discharge function mechanism all belongs to the large intestine cathartic.But also experiment showed, that Semen Pruni water extract and fatty oil thereof have to mouse stomach promotes the intestinal motility effect extremely significantly, and 50% water decoction of Semen Pruni seed can obviously shorten dryness accumulated in the stomach and intestine type Constipation Model mice defecation time, and defecation frequency obviously increases.Specially control QI stagnation of the large intestine, dry puckery obstructed.

Pharmacological action

1, discharge function: the contained Semen Pruni glycoside of Semen Pruni has strong discharge function to laboratory animal.The similar Sennosides of its discharge function mechanism all belongs to the large intestine cathartic.But also experiment showed, that Semen Pruni water extract and fatty oil thereof have to mouse stomach promotes the intestinal motility effect extremely significantly, and 50% water decoction of Semen Pruni seed can obviously shorten dryness accumulated in the stomach and intestine type Constipation Model mice defecation time, and defecation frequency obviously increases.

2, antiinflammatory and analgesic activity: the protein component IR-A and the IR-B intravenously administrable that raise from Semen Pruni have antiinflammatory and analgesic activity.The swelling of on Carrageenan toes, the inhibitory action EB of IR-A is 14.8mg/kg; IR-B is 0.7mg/kg.In addition, mouse writhing method shows that IR-A and IR-B have obvious analgesic activity when the 5mg/kg intravenous injection.The yield that IR-A and IR-B extract from Semen Pruni is respectively 3% and 0.4%.

(9) siritch:

1 〉. contain the unsaturated fatty acid useful to human body in siritch, and the ratio that forms is suitable, is not easy oxidation;

2 〉. especially be rich in and can enhance metabolism, improve the blood capillary circulation, bring the γ type vitamin e of skin cell nutrition, γ type vitamin is that excellent polyphenoils mass-energy prevents cell senescence effectively;

3 〉. the oleic acid composition that contains in siritch is also confirmed that the diseases such as the gastric ulcer of inhibition, asthma are arranged, prevents that skin quality from worsening, and improves the effect of immunity by medical science;

Alpha-linolenic acid in siritch again can blood fat reducing, anticoagulant, vessel softening, tonification brain, cancer, coronary heart disease, diabetes, carcinoma of prostate etc. there is the effect of prevention and treatment, so as long as we are long-term edible siritch, take precautions against fully resource just can for health, could promote the immunologic function of health, so siritch is the best health care condiment in edible oil.

Siritch sweet in the mouth, property are flat, nontoxic, and the effect of moistening dryness for relaxing bowels, nourishing blood to expel wind is arranged.Can cure the disease rear weakness, dizzy, constipation, old man's xerosis cutis, Scaling, allergic dermatitis, pruritus, skin infection eczema and hypertension, sclerosis of blood vessels, cholesterol such as increases at the disease.

The shortage of finding alpha-linolenic acid is the thing of the seventies in last century, the founder Xi Mo Prose doctor at American Genetic nutrient health center, from the omega-fatty acid that begins one's study in 1984 problem of having the balanced diet, China just began one's study in the nineties, provided the more diet style of science from nutrition and healthy angle for the mankind.The formation of omega-fatty acid theory comes from the large essential fatty acid of human body two: alpha-linolenic acid (omega-fatty acid) and linoleic acid (ω-6 fatty acid).Research finds, in the fat that human body is taken in, if the ratio of these two groups of essential fatty acid less than 1: 4, the function of human body will the most efficient, the risk that the various diseases such as cardiovascular, cancer, diabetes, obesity, arthritis, asthma are brought out in reduction.

In recent years, along with the progress of science and technology, the nutritive value of linum and health care have caused many field scientists' such as medical treatment, food, agricultural concern.A large amount of results of study show, siritch is a kind of high-quality edible oil, is rich in α one linolenic acid and various unsaturated fatty acid, can directly change into DHA and EPA in human body.Contain 55% linolenic acid in siritch, this is the highest in vegetable oil, is a kind of economical and practical " bathypelagic fish oil ".As everyone knows, " fish oil " refers to EPA and DHA, is to be become in the body of fish by alpha-linolenic acid (mainly being contained in Sargassum) in the sea.The people takes alpha-linolenic acid (mainly being contained in siritch), also can synthesize EPA and DHA in vivo.So eat the siritch that is rich in alpha-linolenic acid, just can play the effect of similar eating " fish oil "; The unsaturated fatty acid chain of restoration updating cranial nerve cell film plays brain-strengthening, nootropics, blood fat reducing, antiplatelet aggregation, expansion small artery and antithrombotic etc.

Above-mentioned formula after the science screening is compared with other formula, and is strong through taking effect property of animals and human beings body clinical experiment, successful.

Through zoopery, with this soft capsule to mouse stomach, the intestines and stomach be improved significantly, illustrate that this capsule has the function of loosening bowel to relieve constipation; Make mice plasma cAMP, cGMP content all descends, and it is more to descend with cGMP, so cAMP/cGMP ratio organizes cAMP greater than matched group to spleen, and cGMP content all rises, but cAMP/cGMP ratio is without significant change; And the medicine feed experiment mice found no the overt toxicity effect in 30 days, according to the criterion in health food check and assessment technique standard (version in 2003) toxicological evaluation program, the food test agent to the soft capsule that improves anemia without overt toxicity.

Through human experimentation, experiment conclusion: 30 routine constipation experimenters require to take the soft capsule 30 days that helps to improve gastrointestinal function, constipation be improved significantly, reach enhancing immunity, nourishing YIN and supplementing blood, menstruction regulating and pain relieving, eliminating blood stasis to promote regeneration of blood again, inducing diuresis to remove edema also improves the blood oxygen circulation simultaneously, and gastrointestinal function has the effect of the constipation of preventing to significantly improving, illustrate the soft capsule that helps to improve gastrointestinal function.After helping to improve the soft capsule test-meal use of gastrointestinal function, routine blood test, routine urinalysis and blood biochemistry index illustrate that all in normal range this product has no adverse effects for the experimenter is healthy.

Help to improve the soft capsule of gastrointestinal function, every day, dose was every day three times, each two.Main edible crowd is the bad constipation person of gastrointestinal function.

The present invention compares the outstanding feature of following aspect with the formula that helps to improve gastrointestinal function: the present invention adopts the compound recipe form, meticulously select materials, rigorous prescription, pursue integral body and improve the human body situation, from aspect across-the-board regulation healths such as anti-loss, loosening bowel to relieve constipation, blood circulation promoting and blood stasis dispelling, inducing diuresis to remove edema.The human qi and blood running is unobstructed, Metabolism of Normal.The Radix Angelicae Sinensis menstruction regulating and pain relieving, is enriched blood, is invigorated blood circulation at intestine moistening; The Radix Rehmanniae Preparata nourishing YIN and supplementing blood, beneficial essence is filled out marrow; The Radix Polygoni Multiflori removing toxicity for eliminating carbuncles, loosening bowel to relieve constipation; The Semen Cassiae clearing away liver-fire, wind-damp dispelling, tonifying kidney and improving eyesight; The Radix Ophiopogonis YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire; Semen Pruni is moisturized laxation, therapeutic method to keep the adverse QI flowing downwards diuretic; The Rhizoma Polygonati boosting qi and nourishing yin, tonifying speen and tonifying kidney; The Semen Persicae blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation; Siritch has the effect of prevention and treatment to cancer, coronary heart disease, diabetes, carcinoma of prostate etc.Prescription improves health on the whole, improves gastrointestinal function.

2, technique of the present invention is advanced, the high-grade fashion of dosage form.

The related raw material of this formula is allotment after extracting, and has dwindled volume, is convenient to produce, and is comparatively advanced.Select siritch to make solvent, strengthened the effect of this formula.Siritch contains very high unsaturated fatty acid, and linolenic acid content at 55%-60%, is natural health care, and cardiovascular system is had protective effect, also has health-care effect very widely, can reconcile blood glucose, blood fat, blood pressure, supplementing the brain, vision protection etc.

Adopt soft capsule dosage form, can protect to greatest extent active ingredient, can be convenient to again take and digest and assimilate, the high-grade fashion of dosage form.

Existing formula most of the adopt single components such as Radix Rehmanniae Preparata, Radix Angelicae Sinensis, Radix Polygoni Multiflori, linolenic acid that help improve gastrointestinal function relevant to the invention of this class, and the problem that this type of formula exists is that potentiation is relatively poor, and the present invention is more comprehensive, formula has increased Semen Persicae, Rhizoma Polygonati, Semen Cassiae, Radix Ophiopogonis, Semen Pruni, with strong complementarity, potentiation is strong.

The specific embodiment:

Most preferred embodiment shown below is described in further detail:

Feed intake and produce 1000 of 0.6g/ grain soft capsules, formed by following weight portion:

Embodiment 1, a kind of soft capsule that helps to improve gastrointestinal function comprises: siritch 420 weight portions, Radix Angelicae Sinensis extract 20 weight portions, Radix Rehmanniae Preparata extract 10 weight portions, Radix Polygoni Multiflori extract 30 weight portions, Semen Cassiae extract 20 weight portions, Radix Ophiopogonis extract 20 weight portions, Rhizoma Polygonati extract 30 weight portions, Semen Persicae extract 20 weight portions, Semen Pruni extract 30 weight portions;

Embodiment 2, a kind of soft capsule that helps to improve gastrointestinal function comprises: siritch 430 weight portions, Radix Angelicae Sinensis extract 30 weight portions, Radix Rehmanniae Preparata extract 30 weight portions, Radix Polygoni Multiflori extract 10 weight portions, Semen Cassiae extract 20 weight portions, Radix Ophiopogonis extract 10 weight portions, Rhizoma Polygonati extract 20 weight portions, Semen Persicae extract 20 weight portions, Semen Pruni extract 30 weight portions;

Embodiment 3, a kind of soft capsule that helps to improve gastrointestinal function comprises: siritch 445 weight portions, Radix Angelicae Sinensis extract 15 weight portions, Radix Rehmanniae Preparata extract 20 weight portions, Radix Polygoni Multiflori extract 30 weight portions, Semen Cassiae extract 20 weight portions, Radix Ophiopogonis extract 10 weight portions, Rhizoma Polygonati extract 30 weight portions, Semen Persicae extract 10 weight portions, Semen Pruni extract 20 weight portions;

Embodiment 4, a kind of soft capsule that helps to improve gastrointestinal function comprises: siritch 400 weight portions, Radix Angelicae Sinensis extract 30 weight portions, Radix Rehmanniae Preparata extract 30 weight portions, Radix Polygoni Multiflori extract 30 weight portions, Semen Cassiae extract 30 weight portions, Radix Ophiopogonis extract 30 weight portions, Rhizoma Polygonati extract 15 weight portions, Semen Persicae extract 15 weight portions, Semen Pruni extract 20 weight portions;

Embodiment 5, a kind of soft capsule that helps to improve gastrointestinal function comprises: siritch 475 weight portions, Radix Angelicae Sinensis extract 10 weight portions, Radix Rehmanniae Preparata extract 10 weight portions, Radix Polygoni Multiflori extract 10 weight portions, Semen Cassiae extract 15 weight portions, Radix Ophiopogonis extract 15 weight portions, Rhizoma Polygonati extract 20 weight portions, Semen Persicae extract 30 weight portions, Semen Pruni extract 15 weight portions;

Embodiment 6, a kind of preparation method that helps to improve the soft capsule of gastrointestinal function.Comprise the steps:

(1) raw material preparation

Radix Angelicae Sinensis, Radix Rehmanniae Preparata, Radix Polygoni Multiflori, Semen Cassiae, Radix Ophiopogonis, Semen Persicae, Semen Pruni, Rhizoma Polygonati are carried out respectively selected, rinsing twice is drenched and to be anhydrated minute; Be 60～80 ℃ of oven dry 1.5-2 hour in temperature, making its moisture is 5-6%, after coarse pulverization granularity be 5-50mm to add water be 8 times of material, lixiviate 2-8 hour, extract 2 times; Twice filtrate merged, concentrated, be 60-80 ℃ of oven dry 1.5-2 hour in temperature, make its moisture 5-6% of being divided into; Pulverize, sieve, granularity is 0.1-0.5mm, is the Chinese medicine extract fine powder.

The selected slag of removing of flaxseed; Adopt pressafiner that selected flaxseed is squeezed; Again siritch is removed slag, add water and regulate pH value 5.5-6.5, at water temperature 55-65 ℃, fully stir, remove moisture after then precipitating two hours namely to get the refine siritch;

(2) with siritch, the extracts such as Radix Polygoni Multiflori, Radix Angelicae Sinensis, Radix Rehmanniae Preparata, Semen Cassiae, Rhizoma Polygonati, Radix Ophiopogonis, Semen Persicae, Semen Pruni mix in proportion;

(3) press 0.6g/ grain dress soft capsule after mix homogeneously;

(4) sterilization bottling, mounted box;

(5) vanning warehouse-in, sale after the assay was approved.

Claims (4)

1. soft capsule that helps to improve gastrointestinal function is characterized in that including the raw material of following weight portion: siritch 360-520 weight portion, Radix Angelicae Sinensis extract 10-30 weight portion, Radix Rehmanniae Preparata extract 10-30 weight portion.

2. the soft capsule that helps to improve gastrointestinal function as claimed in claim 1 characterized by further comprising the raw material of following weight portion: Radix Polygoni Multiflori extract 10-30 weight portion, Semen Cassiae extract 10-30 weight portion, Radix Ophiopogonis extract 10-30 weight portion.

3. as claim 1 and the 2 described soft capsules that help to improve gastrointestinal function, characterized by further comprising the raw material of following weight portion: Rhizoma Polygonati extract 10-30 weight portion, Semen Persicae extract 10-30 weight portion, Semen Pruni extract 10-30 weight portion.

4. the preparation method that helps to improve the soft capsule of gastrointestinal function as described in claims 1 to 3, is characterized in that, also comprises the steps:

1) raw material preparation

Radix Angelicae Sinensis, Radix Rehmanniae Preparata, Radix Polygoni Multiflori, Semen Cassiae, Radix Ophiopogonis, Semen Persicae, Semen Pruni, Rhizoma Polygonati are carried out respectively selected, rinsing twice is drenched and to be anhydrated minute; Be 60～80 ℃ of oven dry 1.5-2 hour in temperature, making its moisture is 5-6%, after coarse pulverization granularity be 5-50mm to add water be 8 times of material, lixiviate 2-8 hour, extract 2 times; Twice filtrate merged, concentrated, be 60-80 ℃ of oven dry 1.5-2 hour in temperature, make its moisture 5-6% of being divided into; Pulverize, sieve, granularity is 0.1-0.5mm, is the Chinese medicine extract fine powder.

The selected slag of removing of flaxseed; Adopt pressafiner that selected flaxseed is squeezed; Again siritch is removed slag, add water and regulate pH value 5.5-6.5, at water temperature 55-65 ℃, fully stir, remove moisture after then precipitating two hours namely to get the refine siritch;

(2) with siritch, the extracts such as Radix Polygoni Multiflori, Radix Angelicae Sinensis, Radix Rehmanniae Preparata, Semen Cassiae, Rhizoma Polygonati, Radix Ophiopogonis, Semen Persicae, Semen Pruni mix in proportion;

(3) press 0.6g/ grain dress soft capsule after mix homogeneously.