CN101904935A - Chinese medicinal composition for improving immunity of organisms, tonifying middle-jiao and qi and treating canine distemper - Google Patents
Chinese medicinal composition for improving immunity of organisms, tonifying middle-jiao and qi and treating canine distemper Download PDFInfo
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Abstract
The invention relates to a Chinese medicinal composition for treating canine highly contagious disease canine distemper and a preparation method thereof. The Chinese medicinal composition mainly comprises indigowoad root, baical skullcap root, golden thread, gypsum, heartleaf houttuynia herb, liquoric root, honeysuckle flower, weeping forsythia and the like, has the effects of improving the immunity of organisms, tonifying middle-jiao and qi and treating the canine distemper, and is mainly used for dogs. The composition keeps the combined effect of the formula of a traditional Chinese medicine for treatment based on syndrome differentiation by combining modern Chinese medicine development technology according to the theory of traditional Chinese medicine. The composition has the effects of resisting viruses, tonifying middle-jiao and qi, and enhancing the immunity of the organisms, treats both symptoms and root causes, is prepared into tablets, has the advantages of convenient administration, high palatability, and definite treatment effect through clinical verification, and is a pollution-free Chinese medicinal composition for treating the canine distemper.
Description
Technical field
The invention belongs to the veterinary drug technical field, particularly a kind of Chinese medicine composition, human body immunity improving power, invigorating the spleen and replenishing QI that especially a kind of dog is used, Chinese medicine composition of treatment canine distemper and preparation method thereof.
Background technology
Canine distemper is commonly called as the Canis familiaris L. pestilence, and English name is Canine distemper, is the serious dog class disease of a kind of main harm pup.Its pathogen is a canine distemper virus.Sick dog is a feature to present two-phase pattern of fever, rhinitis, serious digestive disorder and respiratory inflammation etc.Encephalitis can take place in the minority case.Ill dog is higher as not treating mortality rate.Canine distemper adopts vaccinate to prevent more, if but the dog of accepting prevention and prevention failure suffer from canine distemper after its mortality rate up to 30%-80%, bring very big loss for the breed of dog.The early stage many employing hyper-immune serums of sick dog of suffering from canine distemper at present, or immunoglobulin, powerful dog health, interferon, monoclonal antibodies etc. are done urgent passive immunity, but these biological preparation price majorities are very expensive, and the treatment cost is too high.At a kind of pure traditional Chinese biological preparation treatment canine distemper of the special invention of this present situation, its prescription is Radix Isatidis, Radix Scutellariae, Rhizoma Coptidis, Gypsum Fibrosum, Herba Houttuyniae, Radix Glycyrrhizae, Flos Lonicerae, Fructus Forsythiae, and effective component extracting adds suitable adjuvant, improve the palatability of medicine, and make tablet, taking convenience, this Chinese medicine preparation human body immunity improving power, invigorating the spleen and replenishing QI, treating both the principal and secondary aspects of a disease, instant effect, the curative effect height, cost is low, is the specific medicament of treatment canine distemper.The drug effect of monarch drug component and clinical practice in the prescription:
1. Radix Isatidis
Radix Isatidis is the root of crucifer ancient name for Chinese cabbage basket and careless Folium Isatidis, or acanthaceous vegetable acanthaceous indigo rhizome and root, contain indigo glycoside, cupreol, isatin, Radix Isatidis crystallization second, Radix Isatidis crystallization third, Radix Isatidis crystallization fourth, contain vegetable protein, resin-like thing, saccharide etc. again.The clinical practice situation is as follows:
(1) prevents and treats epidemic encephalitis type B
Prevention 1 dose of every day, serve on 5 days with Radix Isatidis 3 money decoctions.Treat with the each 2 milliliters of intramuscular injection of 50% or 200% Radix Isatidis injection, every day 2～3 times.Or use the Radix Isatidis decoction, and the nasal feeding of stupor person's row, 2 liang of every days below 12 years old, more than 13 years old 2～4 liang, 1 decoction being taken at a draught or 2 sub-services serve on for 2～3 weeks; Also can obey 1 time in per 2 hours, the adult with 1～2 money, treats cut down according to the circumstance after body temperature is reduced to normally dosage and number of times, drug withdrawal after 2 days at every turn with 2～2.5 money below 15 years old.Need to cooperate anti symptom treatment and supporting treatments such as necessary acupuncture, Western medicine in the therapeutic process.According to the observation of 190 examples, cure rate is more than 90%.Most cases were brought down a fever in 3 days: clinical symptoms all can promptly disappear after bringing down a fever except that the especially severe person usually; Minority has sequela, all is the case that continues hyperpyrexia in the lysis, seriously goes into a coma and twitch.
(2) prevent and treat mumps
With 2～4 liang of Radix Isatidis, children's reduces by half, 1 dose of decoction every day.Simultaneously Radix Isatidis can be made into 30% solution and be coated with the affected part.According to the observed result of 387 examples, except that 5 examples take a turn for the better, 5 examples invalid, all the other are all cured.To relatively poor with complication person's effect.11295 person-times of drug prophylaxiss seemingly have the popular effect of control.
(3) treatment flu (comprising influenza)
With 100% Radix Isatidis injection intramuscular injection, look each 1～6 milliliter of the age and the state of an illness, every day 2～4 times.Treat 80 examples, cure 78 examples, invalid 2 examples (wherein 1 example merges pneumonia).Generally brought down a fever 2～5 days transference cures at 1～3 day.
(4) treatment infectious hepatitis
With 1 liang of Radix Isatidis, 1 dose of decoction every day; Or with 6 jin of Radix Isatidis, 3 jin of Herba Taraxacis, sugared an amount of, make 1000 milliliters of decocts, day clothes 2 times, each 50 milliliters, 15～20 days is a course of treatment.The single decoct is treated 8 examples and is all obtained effect, and transference cure average time is 6 days, and liver function recovery is 15.7 days, and liver is reduced into 13 days.Curative effect is better than the Herba Artemisiae Scopariae Decoction matched group.Compound prescription decoctum is treated 50 examples, has 50% case liver function recovery normal after a course of treatment, and the normal person of first and second accumulative total liver function recovery course of treatment reaches 92%.
2. Radix Scutellariae
Radix Scutellariae is a perennial herb, and main root is grown up, and slightly is coniform, the crust brown.Stem is square, and is high 25～60 centimetres, and the many differences of base portion are smooth or by undercoat.Leaf is to life, ovum shape lanceolar, lanceolar or wire lanceolar, long 1.5～4.5 centimetres, wide 3～12 millimeters, the blunt or anxious point of tip, the base portion circle, above smooth or by undercoat, the gland point is arranged below, smooth or only undercoat is arranged at middle rib; Stockless or short handle is arranged.Raceme pus is given birth to, the flower secund; Calyx is bell, and by the long pubescence of white, tip 5 splits; The corolla lip, upper lip is longer than lower lip, tubular, expand on top, and base portion is very thin, purple, long 2～2.5 centimetres, the surface is by white pubescence; Stamen 4, the last 2; Gynoecium 1, ovary 4 drastic cracks, the style substrate and is given birth to.Pyrene 4, subcircular, black.7～August of florescence.Fruit phase 8～JIUYUE.Be born in the hillside of grassland, high and dry gravel matter.Pharmacological action is as follows:
(1) antibiotic, antiviral
Baicalin 16ng/ml and benzylpenicillin share the minimal effective concentration that can make the golden Portugal resistant strain of neomycin and penicillin and drop to 4ng/ml and 16ng/ml from 125ng/ml and 250ng/ml respectively, and there is dose-effect relationship acyl ammonia antibiotic resistance strain in this class β to be added the baicalin of using 16ng/ml, can recover its antibacterial action, use this class antibiotic for clinical rational theoretical foundation is provided.Baicalin can suppressor T cell and HIV-1 type Env albumen when being lower than cell toxicant concentration, and baicalin can stop it to duplicate at the beginning of HIV-1 is adsorbed, its mechanism of action and key link are to intervene HIV-1 and attack target cell, therefore can be developed into to be new anti-AIDS drug.
(2) antitumor action
Caulis et Folium Scutellariae total flavones and scutellarin have certain inhibitory action to activity of tumor cells, the Caulis et Folium Scutellariae total flavones is the main effective ingredient of Caulis et Folium Scutellariae and scutellarin is the principal monomer composition of Caulis et Folium Scutellariae total flavones, and Caulis et Folium Scutellariae total flavones and principal monomer composition scutellarin thereof suppress percentage rate to the LA795 cell activity and be respectively 25% and 9% under 25 μ g/ml concentration.
(3) antipyretic effect
Radix Scutellariae serum and baicalin are by suppressing mononuclear cell DNA, and stream in protein synthesis and the Ca2+ stops the generation of enogenous pyrogen, makes it have certain refrigeration function.
(4) to the effect of free radical
The noroxylin that extracts from Radix Scutellariae, baicalin and wogonin, the Oxidation that ultraviolet radiation is produced all has the obvious suppression effect.By rayed lipid peroxidation being compared the baicalin depression effect finds, it is by reducing mitochondrion energy expenditure under the anaerobic condition that Radix Scutellariae extract suppresses lipid peroxidation, outside the integrity of the restriction of minimizing succinate oxidation and protection mitochondrial membrane, noroxylin participates in the metabolism of hydrogen peroxide, suppress the oxidation of film system, reduce lipid peroxidation; Baicalin has stronger protective effect to lipid peroxidation injury due to the rat myocardial ischemia and reperfusion, reduces MDA level in the cardiac muscular tissue, SOD activity improving, and protection Na+2K+2ATPase vigor reduces serum creatine kinase, lactic acid dehydrogenase activity.The Radix Scutellariae methanolic extract significantly reduces liver hydroxyproline and MDA level, improves the hepatocyte morphological abnormalities and changes, and has the hepatic fibrosis and the lipid peroxidation that suppress bile duct and stop tetrachloro-methane induction.
The property of medicine of prescription Chinese medicine and function
Radix Isatidis:
[nature and flavor with return through] hardship, cold.GUIXIN, stomach warp.
[function with cure mainly] heat-clearing and toxic substances removing, the removing heat from blood sore-throat relieving.
Radix Scutellariae:
[nature and flavor with return through] hardship, cold.Return lung, gallbladder, spleen, large intestine, small intestine meridian.
[function with cure mainly] heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive.
Rhizoma Coptidis:
[nature and flavor with return through] hardship, cold.GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.
[function with cure mainly] heat clearing and damp drying, eliminating fire and detoxication.
Gypsum Fibrosum:
[nature and flavor with return through] are sweet, hot, Great Cold.Attach to the lung and stomach meridians.
[function with cure mainly] clearing away heat-fire, relieving restlessness is quenched the thirst.
Herba Houttuyniae:
[nature and flavor with return through] suffering is slightly cold.Return lung meridian.
[function with cure mainly] heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus, inducing diuresis for treating stranguria syndrome.
Flos Lonicerae:
[nature and flavor with return through] are sweet, and are cold.Return lung, the heart, stomach warp.
[function with cure mainly] heat-clearing and toxic substances removing, wind-heat dissipating
Fructus Forsythiae:
[nature and flavor with return through] hardship is slightly cold.Return lung, the heart, small intestine meridian.
[function with cure mainly] heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.
Radix Glycyrrhizae:
[nature and flavor with return through] are sweet, flat.GUIXIN, lung, spleen, stomach warp.
[function with cure mainly] invigorating the spleen and replenishing QI, expelling phlegm for arresting cough and middle emergency, detoxifcation, coordinating the actions of various ingredients in a prescription, cushion toxicity, strong.
Summary of the invention
1. one of purpose of the present invention provides a kind of Chinese medicine composition for the treatment of canine distemper, this Chinese medicine composition treating both the principal and secondary aspects of a disease, cure rate height, determined curative effect.
2. another object of the present invention provides the unique preparation process (the same claims of technical matters route) of above-mentioned Chinese medicine composition.
3. the present invention solves its technical problem and is achieved through the following technical solutions:
A kind of human body immunity improving power, invigorating the spleen and replenishing QI, the Chinese medicine composition of treatment canine distemper constitutes component and parts by weight thereof and is respectively:
Radix Isatidis 400-200g Radix Scutellariae 400-200g Rhizoma Coptidis 300-100g Gypsum Fibrosum 300-100g
Herba Houttuyniae 150-50g Radix Glycyrrhizae 150-50g Flos Lonicerae 150-50g Fructus Forsythiae 150-50g
Preferred prescription is:
Radix Isatidis 300g Radix Scutellariae 300g Rhizoma Coptidis 200g Gypsum Fibrosum 200g
Herba Houttuyniae 100g Radix Glycyrrhizae 100g Flos Lonicerae 100g Fructus Forsythiae 100g
A kind of human body immunity improving power, invigorating the spleen and replenishing QI, the unique preparation process of the Chinese medicine composition of treatment canine distemper is as follows:
(1) takes by weighing Radix Isatidis, Radix Scutellariae, Rhizoma Coptidis, Gypsum Fibrosum, Herba Houttuyniae, Radix Glycyrrhizae, Flos Lonicerae, Fructus Forsythiae by weight according to preferred prescription;
(2) Radix Scutellariae adopts 45% alcohol reflux to extract 2 hours, reclaims ethanol, obtains Radix Scutellariae extract;
(3) Radix Scutellariae medicinal residues and all the other each medicines after the alcohol extraction are together adopted 8-12 times of water gaging decocting in water 2-3 time, merge the water extract, vacuum decompression concentrates, and 70% ethanol precipitation reclaims extract;
(4) merge (2), (3) extract, stir and add suitable adjuvant (adjuvant can be starch, Icing Sugar, dextrin, lactose, amylum pregelatinisatum, preferred starch, Icing Sugar) and flavoring agent, granulation, granulate, and make different dosage forms.
The specific embodiment
The invention will be further described below by specific embodiment, and following examples are descriptive, is not determinate, can not limit protection scope of the present invention with this.
Embodiment 1:
A kind of human body immunity improving power, invigorating the spleen and replenishing QI, the Chinese medicine composition of treatment canine distemper, it constitutes component and weight is respectively:
Radix Isatidis 200g Radix Scutellariae 200g Rhizoma Coptidis 100g Gypsum Fibrosum 100g
Herba Houttuyniae 50g Radix Glycyrrhizae 50g Flos Lonicerae 50g Fructus Forsythiae 50g
A kind of unique preparation process of Chinese medicine composition for the treatment of canine distemper is as follows:
(1) takes by weighing Radix Isatidis, Radix Scutellariae, Rhizoma Coptidis, Gypsum Fibrosum, Herba Houttuyniae, Radix Glycyrrhizae, Flos Lonicerae, Fructus Forsythiae by weight;
(2) Radix Scutellariae adopted 45% alcohol reflux 2 hours, reclaimed ethanol, obtained Radix Scutellariae extract;
(3) Radix Scutellariae medicinal residues and all the other each medicines after the alcohol extraction are together adopted 8-12 times of water gaging decocting in water 2-3 time, merge the water extract, vacuum decompression concentrates, and 70% ethanol precipitation reclaims extract;
(4) merge (2), (3) extract, stir and add suitable adjuvant, (adjuvant can be starch, Icing Sugar, dextrin, lactose, amylum pregelatinisatum, preferred starch, Icing Sugar) and flavoring agent, granulation, granulate are made 200 bags of granules.
Embodiment 2:
A kind of human body immunity improving power, invigorating the spleen and replenishing QI, the Chinese medicine composition of treatment canine distemper, it constitutes component and weight is respectively:
Radix Isatidis 400g Radix Scutellariae 400g Rhizoma Coptidis 300g Gypsum Fibrosum 300g
Herba Houttuyniae 150g Radix Glycyrrhizae 150g Flos Lonicerae 150g Fructus Forsythiae 150g
A kind of unique preparation process of Chinese medicine composition for the treatment of canine distemper is as follows:
(1) takes by weighing Radix Isatidis, Radix Scutellariae, Rhizoma Coptidis, Gypsum Fibrosum, Herba Houttuyniae, Radix Glycyrrhizae, Flos Lonicerae, Fructus Forsythiae by weight;
(2) Radix Scutellariae adopted 45% alcohol reflux 2 hours, reclaimed ethanol, obtained Radix Scutellariae extract;
(3) Radix Scutellariae medicinal residues and all the other each medicines after the alcohol extraction are together adopted 8-12 times of water gaging decocting in water 2-3 time, merge the water extract twice, vacuum decompression concentrates, and 70% ethanol precipitation reclaims extract;
(4) merge (2), (3) extract, stir and add suitable adjuvant, (adjuvant can be starch, Icing Sugar, dextrin, lactose, amylum pregelatinisatum, preferred starch, Icing Sugar) and flavoring agent, granulation, granulate are made capsule 400 balls.
Embodiment 3:
The Chinese medicine composition of a kind of human body immunity improving power, invigorating the spleen and replenishing QI, treatment canine distemper, it constitutes component and weight is respectively:
Radix Isatidis 300g Radix Scutellariae 300g Rhizoma Coptidis 200g Gypsum Fibrosum 200g
Herba Houttuyniae 100g Radix Glycyrrhizae 100g Flos Lonicerae 100g Fructus Forsythiae 100g
A kind of unique preparation process of Chinese medicine composition for the treatment of canine distemper is as follows:
(1) takes by weighing Radix Isatidis, Radix Scutellariae, Rhizoma Coptidis, Gypsum Fibrosum, Herba Houttuyniae, Radix Glycyrrhizae, Flos Lonicerae, Fructus Forsythiae by weight;
(2) Radix Scutellariae adopted 45% alcohol reflux 2 hours, reclaimed ethanol, obtained Radix Scutellariae extract;
(3) Radix Scutellariae medicinal residues and all the other each medicines after the alcohol extraction are together adopted 8-12 times of water gaging decocting in water 2-3 time, merge the water extract twice, vacuum decompression concentrates, and 70% ethanol precipitation reclaims extract;
(4) merge (2), (3) extract, stir and add suitable adjuvant, (adjuvant can be starch, Icing Sugar, dextrin, lactose, amylum pregelatinisatum, preferred starch, Icing Sugar) and flavoring agent, granulation, granulate, tabletting are made 300.
Can draw by embodiment: take pure water lift to put forward the method that combines among the present invention, fully extract the effective ingredient of medicine, make tablet, dispensing is convenient, and this prescription has invigorating the spleen and replenishing QI, human body immunity improving power, rapidly and efficiently treats the effect of canine distemper.The clinical treatment that is used for canine distemper.
Embodiment 4: clinical effectiveness
Test material and method
4.1 test reagent: embodiment 3 preparations, interferon (1,000,000 U/ prop up)
4.2 experimental animal: clinical canine distemper disease dog 50 examples (2008) that pet clinic provides.
4.3 test method:
Select the morbidity history sick dog suitable with the state of an illness, be divided into two groups at random, be respectively test group, matched group, 25 every group, test group gives embodiment 3 preparations, every day 2 times, each a slice, logotype 5 days; Matched group gives interferon, every day 1 time, each one, logotype 3 days.
4.4 result of the test
Two kinds of curative effect of medication of table 1 relatively
By result of the test we as can be seen, this Chinese prescription has curative effect preferably to clinical canine distemper, clinical effectiveness is definitely reliable.
Description of drawings Fig. 1 is the process chart of Chinese medicine composition of the present invention.
Claims (5)
1. a human body immunity improving power, invigorating the spleen and replenishing QI, the Chinese medicine composition of treatment canine distemper, it constitutes component and parts by weight are respectively to it is characterized in that this prescription:
Radix Isatidis 400-200g Radix Scutellariae 400-200g Rhizoma Coptidis 300-100g Gypsum Fibrosum 300-100g
Herba Houttuyniae 150-50g Radix Glycyrrhizae 150-50g Flos Lonicerae 150-50g Fructus Forsythiae 150-50g.
2. a kind of human body immunity improving power according to claim 1, invigorating the spleen and replenishing QI, the Chinese medicine composition of treatment canine distemper is characterized in that: wherein preferred prescription is:
Radix Isatidis 300g Radix Scutellariae 300g Rhizoma Coptidis 200g Gypsum Fibrosum 200g
Herba Houttuyniae 100g Radix Glycyrrhizae 100g Flos Lonicerae 100g Fructus Forsythiae 100g.
3. according to a kind of human body immunity improving power as claimed in claim 1 or 2, invigorating the spleen and replenishing QI, the Chinese medicine composition of treatment canine distemper is characterized in that dosage form can make granule, tablet, capsule.
4. according to a kind of human body immunity improving power as claimed in claim 3, invigorating the spleen and replenishing QI, the Chinese medicine composition of treatment canine distemper is characterized in that: the dosage form preferred tablet.
5. according to a kind of human body immunity improving power as claimed in claim 3, invigorating the spleen and replenishing QI, the Chinese medicine composition of treatment canine distemper is characterized in that its unique preparation process is as follows:
(1) takes by weighing Radix Isatidis, Radix Scutellariae, Rhizoma Coptidis, Gypsum Fibrosum, Herba Houttuyniae, Radix Glycyrrhizae, Flos Lonicerae, Fructus Forsythiae by weight;
(2) Radix Scutellariae adopted 45% alcohol reflux 2 hours, reclaimed ethanol, obtained Radix Scutellariae extract;
(3) together adopt 8-12 times of water gaging to decoct 2-3 time the Radix Scutellariae medicinal residues after the alcohol extraction and all the other each medicines, merge the water extract, vacuum decompression concentrates, and 70% ethanol precipitation reclaims extract;
(4) merge (2), (3) extract, stir and add suitable adjuvant, granulation, granulate are made corresponding dosage forms.
The technical matters route is as follows:
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102512547A (en) * | 2011-12-14 | 2012-06-27 | 赵兴友 | Traditional Chinese medicine composition for treating canine distemper virus and preparation method thereof |
| CN103405666A (en) * | 2013-07-25 | 2013-11-27 | 天津集合科技有限公司 | Traditional Chinese medicine composition for treating canine distemper and preparation method thereof |
| CN106177386A (en) * | 2016-08-15 | 2016-12-07 | 赖飞云 | A kind of Chinese medicine composition treating canine distemper |
| CN112121158A (en) * | 2020-10-10 | 2020-12-25 | 吉林省地方病第一防治研究所 | Dry powder based on plague attenuated vaccine and preparation method thereof |
-
2009
- 2009-06-04 CN CN 200910069136 patent/CN101904935A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102512547A (en) * | 2011-12-14 | 2012-06-27 | 赵兴友 | Traditional Chinese medicine composition for treating canine distemper virus and preparation method thereof |
| CN103405666A (en) * | 2013-07-25 | 2013-11-27 | 天津集合科技有限公司 | Traditional Chinese medicine composition for treating canine distemper and preparation method thereof |
| CN106177386A (en) * | 2016-08-15 | 2016-12-07 | 赖飞云 | A kind of Chinese medicine composition treating canine distemper |
| CN112121158A (en) * | 2020-10-10 | 2020-12-25 | 吉林省地方病第一防治研究所 | Dry powder based on plague attenuated vaccine and preparation method thereof |
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Application publication date: 20101208 |