CN102429961B - Medicinal composition capsules for treating cold and preparation method thereof - Google Patents
Medicinal composition capsules for treating cold and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a Chinese medicinal composition for treating cold and a preparation method thereof. The composition comprises the following raw materials in part by weight: 150 to 200 parts of baical skullcap root, 150 to 200 parts of weeping forsythia, 90 to 120 parts of heterophylly falsestarwort root, 90 to 120 parts of fineleaf schizonepeta herb, 50 to 80 parts of cablin potchouli herb, 90 to 120 parts of honeysuckle flower, 90 to 120 parts of indigowoad root, 50 to 80 parts of swordlike atractylodes rhizome, 50 to 80 parts of kudzuvine root and 30 to 60 parts of liquoric root. The composition is prepared by cleaning and wetting medicinal materials, filtering, concentrating, uniformly mixing, loading into capsules, sterilizing, and the like. The composition is abundant in prescription medicine source, short in treatment course and low in medicine price, has an obvious curative effect, is convenient to take and easily accepted by patients, and has a definite curative effect and is safely taken and controllable in quality after being massively and clinically used for years; the preparation process is simple; and the composition is prepared into the capsules, so the composition is convenient to take compared with the traditional decoction and pills, and is easy to clinically popularize and apply.
Description
Technical field
The present invention relates to treat the Chinese medicine composition field of flu, a kind of medicament composition capsule that is used for the treatment of flu particularly the invention still further relates to the preparation method of this Chinese medicine composition.
Background technology
The morbidity of flu accounts for the first place in the exteroreception disease, be modal a kind of, all can fall ill throughout the year, morbidity is many spring, primary disease is not only in close relations with the acute attack of the generation development of coughing and chronic cough, and relevant with deterioration with the PD of multiple diseases such as cardiopalmus, obstruction of qi in the chest and cardialgia, edema, numbness disease, children's, old person are threatened maximum, must the active prevention treatment.Doctor trained in Western medicine thinks that flu is caused that by virus treatment is based on the antiviral agents antibiosis anti-inflammatory drug, but this just controls cold symptoms, causes the abuse of antibiotics sometimes.The Chinese medicine preparation for the treatment of flu at present is various in style, but the side effect of different situations is arranged all, the course for the treatment of that has is long, curative effect is not obvious, the mouthfeel discomfort that has is taken inconvenience, and taking of having is back drowsiness, influence work, the raw material that the has processing cost height of living, expensive etc., all can not satisfy the patient's that catches a cold needs well.
Summary of the invention:
Technical problem to be solved by this invention is the many deficiencies that overcome the Chinese medicine composition existence that is used for the treatment of flu at present, provide a kind of preparation technology simple and not numerous, the medicine valency is cheap, than a kind of Chinese medicine composition that is used for the treatment of flu of traditional decoction, pill taking convenience, the present invention also provides the preparation method of this Chinese medicine composition.
Technical problem of the present invention adopts following technical proposals to solve:
A kind of medicament composition capsule that is used for the treatment of flu, feedstock production by following weight portion forms: Radix Scutellariae 150-200 part, Fructus Forsythiae 150-200 part, Radix Pseudostellariae 90-120 part, Herba Schizonepetae 90-120 part, Herba Pogostemonis 50-80 part, Flos Lonicerae 90-120 part, Radix Isatidis 90-120 part, Rhizoma Atractylodis 50-80 part, Radix Puerariae 50-80 part, Radix Glycyrrhizae 30-60 part.
The described Chinese medicinal composition capsules that is used for the treatment of flu prepares by following processing step:
(1) pulverize: Radix Pseudostellariae, Radix Isatidis, Rhizoma Atractylodis are ground into fine powder, cross 80 mesh sieves, standby;
(2) clean medical material: Radix Scutellariae, Fructus Forsythiae, Herba Schizonepetae, Herba Pogostemonis, Flos Lonicerae, Radix Puerariae, Radix Glycyrrhizae seven flavor raw materials are cleaned clean system;
(3) wet medical material: add 8 times of water gagings and soaked 1 hour, decoct secondary, each 2 hours, collecting decoction;
(4) filter, concentrate: the medical material decocting liquid leaves standstill filtration in 12 hours, and it is 1.10～1.15(50 ℃ that filtrate is concentrated into relative density) clear paste;
(5) encapsulated: the clear paste of above-mentioned (4) was mixed 30 minutes with the fine powder of (1), and mixing, the medicine drying that sticks together is ground into 80 order fine powders, and is encapsulated, makes the capsule of every 0.45g; Use the liquid paraffin polishing;
(6) sterilization: 60 times irradiations of cobalt sterilization in 10 minutes.
Traditional Chinese medicine composition for treating flu curative effect of the present invention is obvious, especially better to the anemopyretic cold curative effect, and through clinical observation, total effective rate reaches 100%.The process that this product adopts can make the active ingredient of prescription medical material fully extract, and has guaranteed this product curative effect, largely dwindles the medicine volume again, facilitates patients, and used side's medicine medicine source abundance is made capsule, is beneficial to clinical application.
Chinese medicine is experienced to emit to wind heat good curative effect, and the present invention is according to Chinese traditional treatment anemopyretic cold heat-clearing and toxic substances removing, and the development of the determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs principle of the dispelling wind that induces sweat is the desirable medication for the treatment of anemopyretic cold.The present invention lays particular emphasis on heat-clearing and toxic substances removing, reuses Radix Scutellariae, Radix Isatidis in the side, strengthens the effect of heat-clearing and toxic substances removing, with the heresy of the heat of dispeling the wind, make lung qi mutually and, the balance of adjustment organismic internal environment, dispeling disease and evil.
Radix Scutellariae among the side of the present invention contains multiple flavone derivative, wherein mainly contains baicalin, wogonoside, baicalin etc., and baicalin etc. are dissolved in ethanol, the water; Radix Pseudostellariae mainly contains fructose, starch, Saponin, and Saponin is water-soluble, in the methanol, ethanol, n-butyl alcohol; Radix Isatidis contains 1-Hydrogen thiocyanate-hydroxyl butylene, adenosine, Palmic acid, and other contains indigo, indirubin and arginine, and is indigo, indirubin dissolubility in water is little, and water extraction is incomplete; Radix Glycyrrhizae contains the triterpenoid compound glycyrrhizin, mainly is the potassium calcium salt of glycyrrhizic acid, and glycyrrhizic acid is through being hydrolyzed to enoxolone, and Radix Glycyrrhizae still contains flavone compound, is mainly liquiritin, liquiritigenin, isoliquiritin etc.; Flos Lonicerae contains flavonoid, is luteolin and luteolin glucoside, and other contains inositol, chlorogenic acid, isochlorogenic acid and saponin, and flavonoid glycoside and chlorogenic acid, isochlorogenic acid and saponin are soluble in water, so this preparation preparing process adopts water boiling and extraction; Contain forsythol, oleanolic acid, flavonol glycosides and saponin, phillyrin, Fructus Forsythiae aglycon etc. in the Fructus Forsythiae peel, effective ingredient forsythol, flavonol glycosides and saponin, phillyrin, Fructus Forsythiae aglycon, soluble in water; Radix Puerariae contains Flavonoid substances, wherein is mainly: daidzin, daidzein and puerarin etc., and flavone and flavonoid glycoside are water-soluble; The Herba Schizonepetae herb contains volatile oil 1～2%, and main component is D-menthone, racemization menthone, and a small amount of d-limonen in the oil; Contain volatile oil 5～9% in the Rhizoma Atractylodis rhizome, main component is atractylol, β-eucalyptol, atisine chloride atractydin etc. in the oil.Volatile oil is water insoluble, and Rhizoma Atractylodis are used as medicine with the former powder of crude drug in this preparation; Herba Pogostemonis contains compositions such as volatile oil patchouli oil, Pogostone.Wherein Radix Pseudostellariae, Radix Scutellariae, Radix Isatidis, the main effective ingredient of Rhizoma Atractylodis are flavone derivative, indigo, indirubin, volatilization wet goods, and water solublity is less, in order to guarantee its curative effect, reduce filler, still medical material is used as medicine with the former powder of medical material; Flos Lonicerae, Fructus Forsythiae, Herba Schizonepetae, Radix Puerariae, Herba Pogostemonis, Radix Glycyrrhizae etc. contain water miscible Saponin, and vegetable polysaccharides, flavonoid glycoside, organic acid chemical compound have certain dissolubility in water.So the part medical material decocts and extracts in this production technology, the part medical material is used as medicine with the former powder of crude drug.
The present invention is monarch drug with Radix Scutellariae, Fructus Forsythiae, and the cool completely effect of evil heat clearing away of existing suffering has the merit of heat-clearing and toxic substances removing repelling foulness with aromatics again.The Herba Schizonepetae of the Xin Wen diffusing wind that induces sweat, principal drug assistance are opened fur and by evil, Flos Lonicerae, Radix Isatidis are ministerial drugs; Heat-clearing and toxic substances removing, opening lung-energy, harmonizing yingfen and weifen with the cloudy gas of the sweetness and bitterness combination of Radix Pseudostellariae, Radix Puerariae; Rhizoma Atractylodis are drying damp and strengthening spleen, expelling wind and cold, and the Herba Pogostemonis eliminating turbid pathogen with aromatics induces sweat, and is all adjuvant drug; The Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription is messenger drug, and all medicines share, and amount to heat-clearing and toxic substances removing, the merit of dispelling wind to relieve the exterior syndrome.Magistral medicines medicine of the present invention source abundance, preparation technology's letter is not and numerous, and the medicine valency is cheap, makes capsule, than traditional decoction, pill taking convenience, is beneficial to clinical application.
The usage and dosage of this Chinese medicine composition: oral, one time 4,3 times on the one or follow the doctor's advice.
The specific embodiment
Embodiment 1
(1) pulverizes: Radix Pseudostellariae 90g, Radix Isatidis 120g, Rhizoma Atractylodis 50g are ground into fine powder, cross 80 mesh sieves;
(2) clean medical material: Radix Scutellariae 150g, Fructus Forsythiae 200g, Herba Schizonepetae 90g, Herba Pogostemonis 50g, Flos Lonicerae 120g, Radix Puerariae 50g, Radix Glycyrrhizae 60g seven flavor raw materials are cleaned clean system;
(3) wet medical material: add 5760g water logging bubble 1 hour, decoct secondary, each 2 hours, collecting decoction;
(4) filter, concentrate: the medical material decocting liquid leaves standstill filtration in 12 hours, and it is 1.15(50 ℃ that filtrate is concentrated into relative density) clear paste;
(5) fine powder that above-mentioned gained clear paste and step (1) are prepared mixed 30 minutes, and mixing, the medicine drying that sticks together is ground into 80 order fine powders, and is encapsulated, made the capsule of every 0.45g, used the liquid paraffin polishing;
(6) sterilization: 60 times irradiations of cobalt sterilization in 10 minutes.
Embodiment 2
(1) Radix Pseudostellariae 120g, Radix Isatidis 90g, Rhizoma Atractylodis 80g are ground into fine powder, cross 80 mesh sieves;
(2) clean medical material: Radix Scutellariae 200g, Fructus Forsythiae 150g, Herba Schizonepetae 120g, Herba Pogostemonis 80g, Flos Lonicerae 90g, Radix Puerariae 80g, Radix Glycyrrhizae 30g seven flavor raw materials are cleaned clean system;
(3) wet medical material: add 6000g water logging bubble 1 hour, decoct secondary, each 2 hours, collecting decoction;
(4) filter, concentrate: the medical material decocting liquid leaves standstill filtration in 12 hours, and it is 1.10(50 ℃ that filtrate is concentrated into relative density) clear paste;
(5) fine powder that above-mentioned gained clear paste and step (1) are prepared mixed 30 minutes, and mixing, the medicine drying that sticks together is ground into 80 order fine powders, and is encapsulated, made the capsule of 0.45g; Use the liquid paraffin polishing.
(6) sterilization
60 times irradiations of cobalt sterilization in 10 minutes.
The clinical efficacy report
1 data and method
1.1 the physical data case is selected from February, 2008-2010 year December, the outpatient service through controlling and inpatient, and all case is all with reference to " Chinese Internal Medicine "
[1]" flu " and " internal medicine "
[2]The diagnostic criteria of " acute upper respiratory tract infection ".Do not have other severe complication, and in twenty four hours prescription on individual diagnosis person as object of study.Clinical more than 800 person-time of the case of observing altogether wherein selected complete case 500 examples, adopts double blind random to be divided into 2 groups.Adopt heat clearing away KANGGAN JIAONANG therapist to claim the treatment group, totally 250 examples, male 130 examples wherein, women 120 examples, age 10-70 year; Adopt the capsule for cold therapist to claim matched group, totally 250 examples, male 128 examples wherein, women 122 examples, age 9-70 year.Two groups of patients are at aspect there was no significant differences such as sex, age, clinical manifestations.
1.2 Therapeutic Method treatment group is treated with the heat clearing away KANGGAN JIAONANG, and each 4, oral, every day three times; Matched group is treated with capsule for cold, and each 2, oral, every day three times.
1.3 the standard that criterion of therapeutical effect adopts the anti-cooperative groups that cures cold in the whole nation to formulate.Produce effects: took medicine 24 hours in, whole body and local cardinal symptom are as disappearances such as heating, watery nasal discharges or disappear substantially.Effectively: took medicine 24～48 hours in, whole body and local symptom are as disappearances such as heating, watery nasal discharges or disappear substantially.Hyperpyrexia (more than 39 ℃) patient, body temperature descended more than 2 ℃ in 24 hours, no longer rise person.Invalid: do not meet above standard person be invalid.
1.4 observation index: produce effects, effectively invalid, obvious effective rate, total effective rate and untoward reaction.Produce effects+effectively=effectively total.
1.5 statistical procedures adopts SPSS13.0 software to carry out statistical procedures, χ is adopted in the difference comparative analysis between treatment group and the matched group
2Check.
2 results
2.1 treatment group and matched group curative effect compare: see Table 1.The obvious effective rate for the treatment of group and matched group is respectively 60.00% and 38.00%; The total effective rate for the treatment of group and matched group is respectively 100.00% and 78.00%.Two groups of obvious effective rate comparing differences have significant statistical significance; Two groups of total effective rate comparing differences have significant statistical significance.
Table 1. liang group clinical efficacy relatively
| Group | The example number | Produce effects | Effectively | Invalid | Obvious effective rate (%) | Total effective rate (%) |
| The treatment group | 250 | 150 | 100 | 0 | 60.00 | 100.00 |
| Matched group | 250 | 95 | 100 | 55 | 38.00 | 78.00 |
Claims (2)
1. medicament composition capsule that is used for the treatment of flu, feedstock production by following weight portion forms: Radix Scutellariae 150-200 part, Fructus Forsythiae 150-200 part, Radix Pseudostellariae 90-120 part, Herba Schizonepetae 90-120 part, Herba Pogostemonis 50-80 part, Flos Lonicerae 90-120 part, Radix Isatidis 90-120 part, Rhizoma Atractylodis 50-80 part, Radix Puerariae 50-80 part, Radix Glycyrrhizae 30-60 part.
2. method for preparing the medicament composition capsule that is used for the treatment of flu according to claim 1, by following processing step preparation:
(1) pulverize: Radix Pseudostellariae, Radix Isatidis, Rhizoma Atractylodis are ground into fine powder, cross 80 mesh sieves, standby;
(2) clean medical material: Radix Scutellariae, Fructus Forsythiae, Herba Schizonepetae, Herba Pogostemonis, Flos Lonicerae, Pueraria lobota, Radix Glycyrrhizae seven flavor raw materials are cleaned clean system;
(3) wet medical material: add 8 times of water gagings and soaked 1 hour, decoct secondary, each 2 hours, collecting decoction;
(4) filter, concentrate: the medical material decocting liquid leaves standstill filtration in 12 hours, and it is 1.10～1.15 clear paste that filtrate is concentrated into 50 ℃ of following relative densities;
(5) encapsulated: the clear paste of (4) was mixed 30 minutes with the fine powder of (1), and mixing, the medicine drying that sticks together is ground into 80 order fine powders, and is encapsulated, makes the capsule of every 0.45g, uses the liquid paraffin polishing;
(6) sterilization: 60 times irradiations of cobalt sterilization in 10 minutes.
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| CN 201110395117 CN102429961B (en) | 2011-12-02 | 2011-12-02 | Medicinal composition capsules for treating cold and preparation method thereof |
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| CN103654045B (en) * | 2013-12-26 | 2015-02-11 | 方统一 | Pillow core provided with traditional Chinese medicine capable of preventing and aiding cold and fever treatment |
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