CN102178733A - Chinese medicinal preparation for treating diabetes and preparation method thereof - Google Patents

Chinese medicinal preparation for treating diabetes and preparation method thereof Download PDF

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CN102178733A
CN102178733A CN201110075779XA CN201110075779A CN102178733A CN 102178733 A CN102178733 A CN 102178733A CN 201110075779X A CN201110075779X A CN 201110075779XA CN 201110075779 A CN201110075779 A CN 201110075779A CN 102178733 A CN102178733 A CN 102178733A
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CN102178733B (en
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吕爱平
吕诚
姜淼
何小娟
张驰
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Institute of Basic Medical Sciences of CAMS
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Abstract

The invention relates to a Chinese medicinal preparation for treating diabetes, which comprises the following Chinese medicinal raw materials in weight proportion: 14 to 16g of red-rooted salvia root, 14 to 16g of astragalus root, 14 to 16g of yam, 14 to 16g of vine root, 9 to 11g of Chinese angelica, 9 to 11g of safflower, and 9 to 11g of ginseng. The preparation method comprises the following steps: cleaning the seven medicinal materials; mixing according to proportion; decocting twice with water in an amount of 5 to 8 times the total weight of the medicinal materials, wherein each decoction takes 1 hour; combining decoctions; and filtering and concentrating to obtain fluid extract with specific gravity of 1.15 at 60 DEG C. The Chinese medicament belongs to compound preparation, can remarkably reduce the level of blood sugar and the content of glycolated hemoglobin, improve the glucose tolerance to a certain extent, promote islet cells to secrete insulin, and does not have acute toxication effect; and compared with the current Chinese medicament for treating diabetes on the market, the Chinese medicament has quick glucose lowering speed, and does not have server adverse reaction of Western medicament products.

Description

A kind of Chinese medicine preparation for the treatment of diabetes and preparation method thereof
Technical field
What the present invention relates to is the technical field of Chinese traditional compound medicine; Especially a kind of Chinese medicine preparation for the treatment of diabetes and preparation method thereof.
Background technology
Diabetes are the lifelong participation diseases that have a strong impact on health of people and life.Along with the world population aging, diabetes have become a kind of commonly encountered diseases, frequently-occurring disease that has a strong impact on human health, are the 3rd killers after tumor, cardiovascular and cerebrovascular disease.In China, the onset diabetes rate rose in nearly 10 years year by year, increased more than 100 ten thousand every year on average.The traditional Chinese medical science is called diabetes quenches one's thirst, and just proposes the surfeit delicious food in Huangdi's Internal Classics, obesity and diabetes confidential relation arranged.Chinese medicine thinks that the morbidity of diabetes will be deficiency of qi and blood in the spleen network, and the expectorant stasis of blood is stagnated stasis of blood resistance at the spleen network, causes the malfunction that transfers of spleen, thereby causes nutrient metabolism disorder, blood sugar increasing.
Food in 2005 and medicine the 7th volume the 6th AThe 31st page of phase " pharmacodynamic study of treatment diabetes Chinese medicine proved recipe " the 1st to 2 row " diabetes spp is in metabolism class disease, cause of disease complexity, and the course of disease is longer.Though clinical used multiple Western medicine blood sugar lowering speed is fast at present, untoward reaction is heavy, happens occasionally as hypoglycemia, lactate poisoning etc.. "
The Chinese medicine and pharmacy Study on Modernization is explored brand-new theory and methodology, for the prescription of further doing anti-diabetic Chinese medicine well has been opened up guiding thinking.The present invention treats the Chinese medicine preparation of diabetes can blood sugar lowering, improve insulin resistant, blood fat reducing, integrally-regulated treatment diabetes.As the new Chinese medicine of treatment diabetes, its feature is to carry out integrally-regulated to diabetics.Can be from many target spots, multi-angle, improve the multiple abnormal index of diabetes at many levels, eliminate thirsty polydipsia, polyphagia, frequent micturition, emaciated physique, the weak diabetic symptom of body especially, and can improve the various complication of diabetes delays the appearance of complication.The advantage of treatment by Chinese herbs diabetes is its integrally-regulated effect, Chinese medicine preparation of the present invention also is like this, but new Chinese medicine of the present invention has had the characteristics of itself maximum again: compound recipe preparation is given Chinese medicine preparation of the present invention and is had quick function of polysaccharide than treatment diabetes Chinese medicine on the present market simultaneously, and does not have untoward reaction.
Though Radix Salviae Miltiorrhizae, the Radix Astragali, Rhizoma Dioscoreae, Radix Puerariae, Radix Angelicae Sinensis, Flos Carthami, Radix Ginseng etc. often are put in the herbal mixture for the treatment of diabetes, the proportioning of therapeutic effect and Radix Salviae Miltiorrhizae, the Radix Astragali, Rhizoma Dioscoreae, Radix Puerariae, Radix Angelicae Sinensis, Flos Carthami, Radix Ginseng is closely-related.
There is not open " treat the Chinese medicine preparation of diabetes, comprise the weight proportion of raw material of Chinese medicine: Radix Salviae Miltiorrhizae 14-16g, Radix Astragali 14-16g, Rhizoma Dioscoreae 14-16g, Radix Puerariae 14-16g, Radix Angelicae Sinensis 9-11g, Flos Carthami 9-11g, Radix Ginseng 9-11g " in the prior art.Will not treat diabetes Chinese medicine blood sugar lowering speed yet and classify the target of compound recipe prescription soon as.
Summary of the invention
The purpose of this invention is to provide a kind of Chinese medicine preparation for the treatment of the treatment of diabetes diabetes and preparation method thereof, pharmaceutical preparation of the present invention can be oral formulations such as tablet, capsule, granule, oral liquid, also can be injection etc.Because it is said preparation adopts Radix Salviae Miltiorrhizae, the Radix Astragali, Rhizoma Dioscoreae, Radix Puerariae, Radix Angelicae Sinensis, Flos Carthami, ginseng composite preparation, not only fast than treatment diabetes Chinese medicine blood sugar lowering speed on the present market.Even reach the fast gliquidone ability of Western medicine.The fast gliquidone ability that herbal mixture reaches Western medicine is very rare.
The Chinese medicine preparation technical scheme of the treatment diabetes that the present invention makes is as follows:
Treat the Chinese medicine preparation of diabetes, comprise the weight proportion of raw material of Chinese medicine: Radix Salviae Miltiorrhizae 14-16g, Radix Astragali 14-16g, Rhizoma Dioscoreae 14-16g, Radix Puerariae 14-16g, Radix Angelicae Sinensis 9-11g, Flos Carthami 9-11g, Radix Ginseng 9-11g.
Scheme one A, the Chinese medicine preparation of treatment diabetes, the weight proportion that comprises raw material of Chinese medicine: Radix Salviae Miltiorrhizae 15g, Radix Astragali 15g, Rhizoma Dioscoreae 15g, Radix Puerariae 15g, Radix Angelicae Sinensis 10g, Flos Carthami 10g, Radix Ginseng 10g, preparation method wherein: 7 flavor medical materials are cleaned, be mixed in proportion, the 5-8 decocting doubly that adds the medical material gross weight boils 2 times, each 1 hour, merge 2 times decoction liquor, filter, and concentrate, proportion is 1.15 fluid extract when obtaining 60 ℃, adopts conventional preparation technology, Chinese medicine preparation of the present invention can be made into said dosage form on any pharmaceutics, as: tablet, capsule, granule, drop pill, oral liquid, pill, syrup, dispersible tablet, effervescent tablet.
Scheme one B, the Chinese medicine preparation of treatment diabetes, the weight proportion that comprises raw material of Chinese medicine: Radix Salviae Miltiorrhizae 15g, Radix Astragali 15g, Rhizoma Dioscoreae 15g, Radix Puerariae 15g, Radix Angelicae Sinensis 10g, Flos Carthami 10g, Radix Ginseng 10g, preparation method wherein: 7 flavor medical materials are cleaned, be mixed in proportion, the 5-8 volumetric concentration doubly that adds the medical material gross weight is that 70% ethanol decocts 2 times, each 1 hour, merge 2 times decoction liquor, filter, and concentrate, proportion is 1.15 fluid extract when obtaining 60 ℃, adopt conventional preparation technology, Chinese medicine preparation of the present invention can be made into said dosage form on any pharmaceutics, as: tablet, capsule, granule, drop pill, oral liquid, pill, syrup, dispersible tablet, effervescent tablet.
Scheme two, the medicinal liquid of scheme one mix homogeneously is concentrated is cooled to room temperature, adds pharmaceutic adjuvant, adopts conventional soft capsule preparation method compacting to be sealed in the soft capsule.
Scheme three, the medicinal liquid of scheme one mix homogeneously is concentrated is cooled to room temperature, adds pharmaceutic adjuvant, adopts conventional solid preparation preparation method to make all kinds of solid preparations.
Scheme four, with the medicinal liquid of scheme one mix homogeneously by recipe quantity, adopt conventional method to make ejection preparation.
Treat the Chinese medicine preparation of diabetes, comprise the weight proportion of raw material of Chinese medicine: Radix Salviae Miltiorrhizae 5-20g, Radix Astragali 5-20g, Rhizoma Dioscoreae 5-20g, Radix Puerariae 5-20g, Radix Angelicae Sinensis 5-15g, Flos Carthami 5-15g, Radix Ginseng 5-15g.
The purpose of this invention is to provide a kind of Chinese medicine preparation for the treatment of the treatment of diabetes diabetes and preparation method thereof, compound recipe preparation, significantly the content of blood sugar lowering level and glycolated hemoglobin, to a certain extent improve carbohydrate tolerance, promotion islet cells excreting insulin, do not have acute intoxicating effect; Not only fast than treatment diabetes Chinese medicine blood sugar lowering speed on the present market.Even reach the fast gliquidone ability of Western medicine.The fast gliquidone ability that herbal mixture reaches Western medicine is very rare.And there is not the severe untoward reaction of Western medicine product.
Advantage of the present invention: supplementing QI and nourishing YIN, promoting the production of body fluid to quench thirst, can improve xerostomia, constipation, clinical symptoms such as weak, the content of remarkable blood sugar lowering level and glycolated hemoglobin, improve carbohydrate tolerance to a certain extent, promote the islet cells excreting insulin, do not have acute intoxicating effect, and can quick blood sugar lowering.
The Chinese medicine preparation of the treatment diabetes that relate in technical scheme of the present invention comprises the following weight Chinese medicinal raw materials: Radix Salviae Miltiorrhizae 15g, Radix Astragali 15g, Rhizoma Dioscoreae 15g, Radix Puerariae 15g, Radix Angelicae Sinensis 10g, Flos Carthami 10g, Radix Ginseng 10g.
Radix Salviae Miltiorrhizae of the present invention, the Radix Astragali, Rhizoma Dioscoreae, Radix Puerariae, Radix Angelicae Sinensis, Flos Carthami, Radix Ginseng are prepared as the medicinal ingredient compound recipe, the advantage that had both possessed common Chinese, significantly the content of blood sugar lowering level and glycolated hemoglobin, to a certain extent improve carbohydrate tolerance, promote the islet cells excreting insulin, this is that this Chinese medicine sample can be treated one of reason of diabetes, does not have acute intoxicating effect simultaneously; And there is not the severe untoward reaction of Western medicine product.
The specific embodiment:
The Chinese medicine preparation of embodiment 1, treatment diabetes comprises the following weight Chinese medicinal raw materials: Radix Salviae Miltiorrhizae 15g, Radix Astragali 15g, Rhizoma Dioscoreae 15g, Radix Puerariae 15g, Radix Angelicae Sinensis 10g, Flos Carthami 10g, Radix Ginseng 10g;
Wherein, the preparation method of the Chinese medicine preparation of treatment diabetes is:
7 flavor medical materials are cleaned, be mixed in proportion, 6 times the decocting that adds the medical material gross weight boils 2 times, and each 1 hour, merge 2 times decoction liquor, to filter, and concentrate, proportion is 1.15 fluid extract when obtaining 60 ℃.
The Chinese medicine preparation of embodiment 2, treatment diabetes comprises the following weight Chinese medicinal raw materials: Radix Salviae Miltiorrhizae 16g, Radix Astragali 16g, Rhizoma Dioscoreae 16g, Radix Puerariae 16g, Radix Angelicae Sinensis 11g, Flos Carthami 11g, Radix Ginseng 11g;
Wherein, the preparation method of the Chinese medicine preparation of treatment diabetes is:
7 flavor medical materials are cleaned, be mixed in proportion, 7 times the volumetric concentration that adds the medical material gross weight is that 70% ethanol decocts 2 times, each 1 hour, merges 2 times decoction liquor, and filter, and concentrated, proportion is 1.15 fluid extract when obtaining 60 ℃.
The Chinese medicine preparation of embodiment 3, treatment diabetes comprises the following weight Chinese medicinal raw materials: Radix Salviae Miltiorrhizae 14g, Radix Astragali 14g, Rhizoma Dioscoreae 14g, Radix Puerariae 14g, Radix Angelicae Sinensis 9g, Flos Carthami 9g, Radix Ginseng 9g.
Wherein, the preparation method of the Chinese medicine preparation of treatment diabetes is:
7 flavor medical materials are cleaned, be mixed in proportion, 7 times the decocting that adds the medical material gross weight boils 2 times, and each 1 hour, merge 2 times decoction liquor, to filter, and concentrate, proportion is 1.15 fluid extract when obtaining 60 ℃.
The middle Chinese medicine preparation of embodiment 4, treatment diabetes comprises the following weight Chinese medicinal raw materials: Radix Salviae Miltiorrhizae 18g, Radix Astragali 18g, Rhizoma Dioscoreae 12g, Radix Puerariae 15g, Radix Angelicae Sinensis 10g, Flos Carthami 10g, Radix Ginseng 10g.
Wherein, the preparation method of the Chinese medicine preparation of treatment diabetes is:
7 flavor medical materials are cleaned, be mixed in proportion, 8 times the volumetric concentration that adds the medical material gross weight is that 70% ethanol decocts 2 times, each 1 hour, merges 2 times decoction liquor, and filter, and concentrated, proportion is 1.15 fluid extract when obtaining 60 ℃.
The Chinese medicine preparation of embodiment 5, treatment diabetes comprises the following weight Chinese medicinal raw materials: Radix Salviae Miltiorrhizae 15g, Radix Astragali 15g, Rhizoma Dioscoreae 10g, Radix Puerariae 18g, Radix Angelicae Sinensis 12g, Flos Carthami 12g, Radix Ginseng 12g.
Wherein, the preparation method of the Chinese medicine preparation of treatment diabetes is:
7 flavor medical materials are cleaned, be mixed in proportion, 5 times the decocting that adds the medical material gross weight boils 2 times, and each 1 hour, merge 2 times decoction liquor, to filter, and concentrate, proportion is 1.12 fluid extract when obtaining 70 ℃.
The Chinese medicine preparation of embodiment 6, treatment diabetes comprises the following weight Chinese medicinal raw materials: Radix Salviae Miltiorrhizae 12g, Radix Astragali 12g, Rhizoma Dioscoreae 8g, Radix Puerariae 15g, Radix Angelicae Sinensis 10g, Flos Carthami 10g, Radix Ginseng 10g.
Wherein, the preparation method of the Chinese medicine preparation of treatment diabetes is:
7 flavor medical materials are cleaned, be mixed in proportion, 5 times the volumetric concentration that adds the medical material gross weight is that 70% ethanol decocts 2 times, each 1 hour, merges 2 times decoction liquor, and filter, and concentrated, proportion is 1.15 fluid extract when obtaining 60 ℃.
The Chinese medicine preparation of embodiment 7, treatment diabetes comprises the following weight Chinese medicinal raw materials: Radix Salviae Miltiorrhizae 15g, Radix Astragali 15g, Rhizoma Dioscoreae 10g, Radix Puerariae 12g, Radix Angelicae Sinensis 8g, Flos Carthami 8g, Radix Ginseng 8g.
Wherein, the preparation method of the Chinese medicine preparation of treatment diabetes is:
7 flavor medical materials are cleaned, be mixed in proportion, 6 times the decocting that adds the medical material gross weight boils 2 times, and each 1 hour, merge 2 times decoction liquor, to filter, and concentrate, proportion is 1.15 fluid extract when obtaining 60 ℃.
The Chinese medicine preparation of embodiment 8, treatment diabetes comprises the following weight Chinese medicinal raw materials: Radix Salviae Miltiorrhizae 18g, Radix Astragali 18g, Rhizoma Dioscoreae 10g, Radix Puerariae 15g, Radix Angelicae Sinensis 10g, Flos Carthami 10g, Radix Ginseng 10g.
Wherein, the preparation method of the Chinese medicine preparation of treatment diabetes is:
7 flavor medical materials are cleaned, be mixed in proportion, 7 times the volumetric concentration that adds the medical material gross weight is that 70% ethanol decocts 2 times, each 1 hour, merges 2 times decoction liquor, and filter, and concentrated, proportion is 1.15 fluid extract when obtaining 60 ℃.
The Chinese medicine preparation of embodiment 9, treatment diabetes comprises the following weight Chinese medicinal raw materials: Radix Salviae Miltiorrhizae 15g, Radix Astragali 15g, Rhizoma Dioscoreae 12g, Radix Puerariae 18g, Radix Angelicae Sinensis 10g, Flos Carthami 10g, Radix Ginseng 10g.
Wherein, the preparation method of the Chinese medicine preparation of treatment diabetes is:
7 flavor medical materials are cleaned, be mixed in proportion, 8 times the decocting that adds the medical material gross weight boils 2 times, and each 1 hour, merge 2 times decoction liquor, to filter, and concentrate, proportion is 1.15 fluid extract when obtaining 60 ℃.
The Chinese medicine preparation of embodiment 10, treatment diabetes comprises the following weight Chinese medicinal raw materials: Radix Salviae Miltiorrhizae 15g, Radix Astragali 15g, Rhizoma Dioscoreae 10g, Radix Puerariae 15g, Radix Angelicae Sinensis 12g, Flos Carthami 12g, Radix Ginseng 10g.
7 flavor medical materials are cleaned, be mixed in proportion, 8 times the volumetric concentration that adds the medical material gross weight is that 70% ethanol decocts 2 times, each 1 hour, merges 2 times decoction liquor, and filter, and concentrated, proportion is 1.15 fluid extract when obtaining 60 ℃.
The Chinese medicine preparation of embodiment 11, treatment diabetes comprises the following weight Chinese medicinal raw materials: Radix Salviae Miltiorrhizae 15g, Radix Astragali 15g, Rhizoma Dioscoreae 10g, Radix Puerariae 15g, Radix Angelicae Sinensis 8g, Flos Carthami 8g, Radix Ginseng 8g.
Wherein, the preparation method of the Chinese medicine preparation of treatment diabetes is:
7 flavor medical materials are cleaned, be mixed in proportion, 7 times the decocting that adds the medical material gross weight boils 2 times, and each 1 hour, merge 2 times decoction liquor, to filter, and concentrate, proportion is 1.15 fluid extract when obtaining 60 ℃.
The Chinese medicine preparation of embodiment 12, treatment diabetes, comprise the following weight Chinese medicinal raw materials: Radix Pseudostellariae, the Radix Astragali, Radix Rehmanniae, Poria, Radix Salviae Miltiorrhizae, each 30g of Rhizoma Dioscoreae, Radix Et Rhizoma Rhei, Rhizoma Coptidis, Polyporus, Flos Carthami 10g, Radix Angelicae Sinensis, Radix Adenophorae (Radix Glehniae), Fructus Lycii, Radix Polygoni Multiflori Preparata, each 15g of Radix Puerariae.
Wherein, the preparation method of the Chinese medicine preparation of treatment diabetes is:
Above-mentioned 15 flavor medical materials are cleaned, be mixed in proportion, 7 times the decocting that adds the medical material gross weight boils 2 times, and each 1 hour, merge 2 times decoction liquor, to filter, and concentrate, proportion is 1.15 fluid extract when obtaining 60 ℃.
Embodiment 13, adopt conventional preparation technology, Chinese medicine preparation of the present invention can be made into said dosage form cream on any pharmaceutics, as: tablet, capsule, granule, drop pill, oral liquid, pill, syrup, dispersible tablet, effervescent tablet, all the other are with embodiment 1-12.
The fluid extract of embodiment 14, the mix homogeneously that will be made by embodiment 1-12 concentrates, operational approach according to conventional tablet, add pharmaceutic adjuvant, with each component mix homogeneously, wet granulation, be cooled to room temperature, and to adopt the compacting of conventional soft capsule preparation method to be sealed in the soft capsule be that fill becomes capsule, wherein each components contents is as follows:
Composition weight (part)
Mixed flow extractum 10
Lactose 5
Dextrin 9
Microcrystalline Cellulose 5
All the other are with embodiment 1-12.
The fluid extract of embodiment 15, the mix homogeneously that will be made by embodiment 1-11 concentrates, add an amount of water for injection dissolving, add ethanol, be settled to 1000ml, regulate pH value between the 4.0-5.5, aseptic filtration, be cooled to room temperature, add pharmaceutic adjuvant, make tablet according to the conventional tablet preparation method, wherein each components contents is as follows:
Composition weight (part)
Mixed flow extractum 100
Ethanol 200
Starch 25
Pulvis Talci 15
Magnesium stearate 2
All the other are with embodiment 1-11.
The medicinal liquid of embodiment 16, the mix homogeneously that will be made by embodiment 1-12 is by recipe quantity and adopt conventional method to be dissolved in an amount of water for injection, the injection water soluble adjuvant that adds metering, the active carbon that adds 0.1-0.5% is removed pyrogen, regulate PH to 6.0-7.5, after the microporous filter membrane ultrafiltration, replenish water for injection to ormal weight, fill is in ampoule bottle or in the infusion bottle, sealing by fusing/roll lid, through after the assay was approved, packing promptly gets ejection preparation.All the other are with embodiment 1-12.
Test example 1
Test material:
Animal: normal rat ♂ ♀ dual-purpose.
The source: animal testing center, Beijing provides.
Test method
The blood sugar lowering speed trial
Get 200 of healthy normal rats, fasting 12h can't help water.Lumbar injection (streptozotocin) STZ solution 65mg/kg (1% concentration).After 5 days, the tail vein is got blood, detects its fasting glucose.Getting blood glucose value is 130 of hyperglycemic rats more than 16.7mmol/L, every group 10, the Chinese medicine fluid extract of the treatment diabetes that make by embodiment 1,2,3,4,5,6,7,8,9,10,11,12 be divided into the Western medicine compound recipe glibenclamide oral liquid buied on A, B, C, D, E, F, G, H, I, J, 12 groups of K, L and the market totally ten three groups irritate stomaches and be subjected to the reagent thing, every day every Mus 0.4ml.Other gets 10 euglycemia Mus, irritates stomach 0.4ml normal saline every day, as normal control.1d, 3d, 7d, 14d, 30d, 60d check that medicine is to rat blood sugar lowering speed effect.
Table 1 blood sugar lowering speed and curative effect:
The result: comprehensive above conclusion can know that making the Chinese medicine for the treatment of diabetes by embodiment 1,2,3 promptly has fast than treatment diabetes Chinese medicine blood sugar lowering speed on the present market.It is better more obvious to make the Chinese medicine hypoglycemic effect for the treatment of diabetes by embodiment 1,2,3 simultaneously, and does not have the side effect of Western medicine.Full side's compatibility is rigorous, and effect is outstanding, so hypoglycemic effect is more obvious in practice.

Claims (7)

1. the Chinese medicine preparation of treatment diabetes comprises following raw material of Chinese medicine: Radix Salviae Miltiorrhizae, the Radix Astragali, Radix Puerariae.
2. the Chinese medicine preparation of treatment diabetes comprises the following weight Chinese medicinal raw materials: Radix Salviae Miltiorrhizae 14-16g, Radix Astragali 14-16g, Rhizoma Dioscoreae 14-16g, Radix Puerariae 14-16g, Radix Angelicae Sinensis 9-11g, Flos Carthami 9-11g, Radix Ginseng 9-11g.
3. the Chinese medicine preparation of treatment diabetes comprises the following weight Chinese medicinal raw materials: Radix Salviae Miltiorrhizae 15g, Radix Astragali 15g, Rhizoma Dioscoreae 15g, Radix Puerariae 15g, Radix Angelicae Sinensis 10g, Flos Carthami 10g, Radix Ginseng 10g.
4. as the preparation method of the Chinese medicine preparation of claim 2 or 3 described treatment diabetes, it is characterized in that: 7 flavor medical materials are cleaned, be mixed in proportion, the 5-8 decocting doubly that adds the medical material gross weight boils 2 times, each 1 hour, merges 2 times decoction liquor, filter, and concentrate, obtain fluid extract.
5. as the preparation method of the Chinese medicine preparation of claim 2 or 3 described treatment diabetes, it is characterized in that: 7 flavor medical materials are cleaned, be mixed in proportion, the 5-8 volumetric concentration doubly that adds the medical material gross weight is that 70% ethanol decocts 2 times, each 1 hour, merge 2 times decoction liquor, filter, and concentrate, obtain fluid extract.
6. treat the preparation method of the Chinese medicine preparation of diabetes, it is characterized in that: comprise the following weight Chinese medicinal raw materials: Radix Salviae Miltiorrhizae 15g, Radix Astragali 15g, Rhizoma Dioscoreae 15g, Radix Puerariae 15g, Radix Angelicae Sinensis 10g, Flos Carthami 10g, Radix Ginseng 10g, 7 flavor medical materials are cleaned, be mixed in proportion, 6 times the decocting that adds the medical material gross weight boils 2 times, each 1 hour, merge 2 times decoction liquor, filter, and concentrate, proportion is 1.15 fluid extract when obtaining 60 ℃, adopts conventional preparation technology to make tablet, capsule, granule, drop pill, oral liquid, pill, syrup, dispersible tablet, effervescent tablet.
7. treat the preparation method of the Chinese medicine preparation of diabetes, it is characterized in that: comprise the following weight Chinese medicinal raw materials: Radix Salviae Miltiorrhizae 15g, Radix Astragali 15g, Rhizoma Dioscoreae 15g, Radix Puerariae 15g, Radix Angelicae Sinensis 10g, Flos Carthami 10g, Radix Ginseng 10g, 7 flavor medical materials are cleaned, be mixed in proportion, 7 times the volumetric concentration that adds the medical material gross weight is 70% ethanol, each 1 hour, merge 2 times decoction liquor, filter, and concentrate, proportion is 1.15 fluid extract when obtaining 60 ℃, adopts conventional preparation technology to make tablet, capsule, granule, drop pill, oral liquid, pill, syrup, dispersible tablet, effervescent tablet.
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CN102406800A (en) * 2011-11-29 2012-04-11 宋爱民 Chinese medicine preparation for treating qi-yin deficiency type diabetes mellitus
CN102526420A (en) * 2011-12-31 2012-07-04 陕西步长制药有限公司 Traditional Chinese medicine preparation for treating diabetes and preparation method thereof
CN103223087A (en) * 2013-05-13 2013-07-31 谭格铭 Food therapy formula for treating diabetes mellitus
CN104367726A (en) * 2014-11-12 2015-02-25 哈尔滨灵草舒生物科技有限公司 Blood sugar-reducing and qi and blood-replenishing sleep regulating tea and production method thereof

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CN107669860A (en) * 2017-09-26 2018-02-09 河南大学 A kind of Chinese medicine composition and its application with blood sugar reducing function

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Publication number Priority date Publication date Assignee Title
CN102406800A (en) * 2011-11-29 2012-04-11 宋爱民 Chinese medicine preparation for treating qi-yin deficiency type diabetes mellitus
CN102526420A (en) * 2011-12-31 2012-07-04 陕西步长制药有限公司 Traditional Chinese medicine preparation for treating diabetes and preparation method thereof
CN103223087A (en) * 2013-05-13 2013-07-31 谭格铭 Food therapy formula for treating diabetes mellitus
CN104367726A (en) * 2014-11-12 2015-02-25 哈尔滨灵草舒生物科技有限公司 Blood sugar-reducing and qi and blood-replenishing sleep regulating tea and production method thereof

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