CN102743584A - Traditional Chinese medicine for decreasing blood sugar and preparation method thereof - Google Patents
Traditional Chinese medicine for decreasing blood sugar and preparation method thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine for decreasing blood sugar and a preparation method thereof. Active pharmaceutical ingredients of the traditional Chinese medicine for decreasing the blood sugar comprises extracts and 10-12 parts by weight of buck wheat flour, wherein the extracts are extracted by water decocting or alcohol refluxing a mixture of 45-55 parts by weight of astragalus, 28-32 parts by weight of polygonatum, 28-32 parts by weight of polygonatum odoratum, 38-42 parts by weight of cortex lycii radicis, 18-22 parts by weight of rhizoma dioscoreae and 18-22 parts by weight of rhizoma alismatis. The preparation method comprises the steps of mixing astragalus, polygonatum, polygonatum odoratum, cortex lycii radicis, rhizoma dioscoreae and rhizoma alismatis, adding water into the mixture and decocting, concentrating a drug solution to obtain an extract, or extracting by alcohol reflux, concentrating a drug solution to obtain an extract; and mixing the extract obtained from one of the above method and buck wheat flour to obtain the traditional Chinese medicine for decreasing the blood sugar. The traditional Chinese medicine for decreasing the blood sugar has the beneficial effects of providing novel traditional Chinese medicine species effective in treatment for treating hyperglycemia diseases.
Description
Technical field
The invention belongs to field of medicaments, be specifically related to a kind of hypoglycemic Chinese medicine.
Background technology
Before this, there have been several hypoglycemic Chinese patent medicines in hyperglycemia population, to use, but do not seen that therapeutic effect is comparatively outstanding, the comparatively universally recognized kind of ability quilt.
Summary of the invention
The purpose of this invention is to provide a kind of hypoglycemic Chinese medicine and method for preparing, for treatment hyperglycemia disease provides new herbal species, in the hope of improving the curative effect of Chinese medicine in the treatment hyperglycemia.
Antidiabetic drug of the present invention: the extract and the Radix Et Rhizoma Fagopyri Tatarici powder 10-12 weight portion that are mixed back water boiling and extraction or alcohol reflux by Radix Astragali 45-55 weight portion, Rhizoma Polygonati 28-32 weight portion, Rhizoma Polygonati Odorati 28-32 weight portion, Cortex Lycii 38-42 weight portion, Rhizoma Dioscoreae 18-22 weight portion, Rhizoma Alismatis 18-22 weight portion are formed medicinal active ingredient.
The best medical material usage ratio of antidiabetic drug of the present invention is: the Radix Astragali 50 weight portions, Rhizoma Polygonati 30 weight portions, Rhizoma Polygonati Odorati 30 weight portions, Cortex Lycii 40 weight portions, Rhizoma Dioscoreae 20 weight portions, Rhizoma Alismatis 20 weight portions, Radix Et Rhizoma Fagopyri Tatarici 11 weight portions.
Method for preparing of the present invention comprises:
Method 1
(1) gets Radix Astragali 45-55 weight portion, Rhizoma Polygonati 28-32 weight portion, Rhizoma Polygonati Odorati 28-32 weight portion, Cortex Lycii 38-42 weight portion, Rhizoma Dioscoreae 18-22 weight portion, Rhizoma Alismatis 18-22 weight portion, Radix Et Rhizoma Fagopyri Tatarici 10-12 weight portion;
(2) step (1) Radix Astragali of getting, Rhizoma Polygonati, Rhizoma Polygonati Odorati, Cortex Lycii, Rhizoma Dioscoreae, Rhizoma Alismatis are mixed, add 8 times of water logging bubbles of medical material weight 1h, decoct 2h again, filter filtrate for later use;
(3) medicinal residues that step (2) leached add the water with step (2) equivalent again, decoct 2h again, filter, and must filtrate;
(4) combining step (2), (3) gained filtrating, quiescent setting 6h gets the supernatant centrifugal treating;
(5) will under 70-80 ℃, 0.075-0.085Mpa condition, be evaporated to the thick extractum of 60 ℃ of lower density 120-130 through medicinal liquid that step (4) is handled;
(6) step (1) Radix Et Rhizoma Fagopyri Tatarici of getting is sterilized with the 5kgy amount of radiation with cobalt 60;
(7) will be broken into 80-100 purpose fine powder through the Radix Et Rhizoma Fagopyri Tatarici powder of step (6) sterilization;
(8) the thick extractum with step (5) gained mixes with the Radix Et Rhizoma Fagopyri Tatarici powder of step (7) gained, concentrating under reduced pressure under 70-80 ℃, 0.075-0.085Mpa condition, dry extract shape blood-sugar lowering tcm drug;
(9) step (8) gained dry extract is broken into extract powder and mixes with dextrine powder 1.5 weight portions, encapsulated, get blood-sugar lowering tcm drug capsule of the present invention, or, process conventional peroral dosage form extract powder and other pharmaceutical carrier commonly used or mixed with excipients.
Method 2
(1) gets Radix Astragali 45-55 weight portion, Rhizoma Polygonati 28-32 weight portion, Rhizoma Polygonati Odorati 28-32 weight portion, Cortex Lycii 38-42 weight portion, Rhizoma Dioscoreae 18-22 weight portion, Rhizoma Alismatis 18-22 weight portion, Radix Et Rhizoma Fagopyri Tatarici 10-12 weight portion;
(2) step (1) Radix Astragali of getting, Rhizoma Polygonati, Rhizoma Polygonati Odorati, Cortex Lycii, Rhizoma Dioscoreae, Rhizoma Alismatis are mixed; Add medical material weight 10-20 doubly, concentration is 50~90% alcohol reflux 2~4 times; Each time is 0.5~3h; Reclaim ethanol, merge extractive liquid, is evaporated to extracting solution the thick extractum of 60 ℃ of lower density 1.20-1.30 under 70-80 ℃, 0.075-0.085Mpa condition;
(3) step (1) Radix Et Rhizoma Fagopyri Tatarici of getting is sterilized with the 5kgy amount of radiation with cobalt 60;
(4) will be broken into 80-100 purpose fine powder through the Radix Et Rhizoma Fagopyri Tatarici powder of step (3) sterilization;
(5) the thick extractum with step (2) gained mixes with the Radix Et Rhizoma Fagopyri Tatarici powder of step (4) gained, concentrating under reduced pressure under 70-80 ℃, 0.075-0.085Mpa condition, dry extract shape blood-sugar lowering tcm drug;
(6) step (5) gained dry extract is broken into extract powder and mixes with dextrine powder 1.5 weight portions, encapsulated, get blood-sugar lowering tcm drug capsule of the present invention, or, process conventional peroral dosage form extract powder and other pharmaceutical carrier commonly used or mixed with excipients.
Instructions of taking and consumption: oral, every day 2 times, each 1.2-1.5g.
The invention has the beneficial effects as follows: with the Radix Astragali, Rhizoma Polygonati is principal agent, the ability benefiting QI for strengthening the superficies, and YIN nourishing and the production of body fluid promoting is monarch; With Rhizoma Polygonati Odorati, Cortex Lycii is minister, assists nourishing YIN to relieve dryness, promoting the production of body fluid to quench thirst; Assistant makes body fluid that the source of money life arranged with Rhizoma Dioscoreae, Rhizoma Alismatis strengthening spleen, tonifying kidney, promoting diuresis with drugs of tasteless flavour; Use Radix Et Rhizoma Fagopyri Tatarici for making less, physical strength profiting, continuous spirit, sharp knowledge have the wide intestinal digestion promoting function of sending down the abnormal ascending QI.All raw materials share common accent and mend internal organs, from QI invigorating kidney tonifying, nourishing YIN and clearing away heat, and then reach auxiliary hyperglycemic, for treatment hyperglycemia disease provides Chinese medicine new varieties evident in efficacy.
Compliance test result
, claim in the test in " Chinese medicine of the present invention " as the test medication with the Chinese medicine of the present invention of capsule formulation.
One, Chinese medicine of the present invention is to the influence of epinephrine type hyperglycemic rat blood sugar level
Get 60 of healthy male rats, be divided into 6 groups at random. 10 every group.Be respectively the normal control group, model group, the high, medium and low dosage of Chinese medicine of the present invention (0.50,0.25,0.13g/kg) group, ginseng stilbene Chinese medicine of the present invention (0.5g/kg) group.All by the volume gastric infusion of 1ml/100g body weight, normal control group and model group give distilled water.Every day 1 time, 15d continuously.Water 12d is can't help in fasting before the last administration, 1.5h after the last administration, and except that the normal control group, each organizes equal lumbar injection epinephrine 0.5mg/kg, irritates stomach glucose solution 1g/kg simultaneously, to strengthen modeling.Respectively at after the modeling 1,2,3h surveys blood sugar content on an empty stomach, all takes the determination of glucose oxidase serum glucose level.The result sees table 1.
The result shows that Chinese drug-treated group of the present invention can obviously reduce epinephrine type hyperglycemic rat blood sugar level, and is remarkable with the model group comparing difference.
Two, Chinese medicine of the present invention is to the influence of alloxan type hyperglycemic rat blood glucose, insulin level
Choose 70 of healthy rats, water 12h is can't help in fasting, and 72h behind the ip alloxan 160mg/kg cuts the tail blood sampling and measures blood glucose.40 (blood glucose values 16-21mmol/L) of the approaching hyperglycemic rat of blood sugar level are selected in higher and 20 lower rejectings with blood glucose in the modeling rat.Be divided into 5 groups at random, 10 every group.Be respectively model control group, the large, medium and small dosage of Chinese medicine of the present invention (0.5,2.5,1.3g/kg) group, SHENQI JIANGTANG glue (0.4g/kg) group, other gets 10 of healthy rats and makes the normal control group, and the gastric infusion method is the same.Water 12h is can't help in fasting before the last administration, and 1.5h cuts the tail blood sampling after the last administration, determination of glucose oxidase blood glucose, and radiation epidemic disease method is measured insulin level, and the result sees table 2.
The result shows that Chinese drug-treated group of the present invention can obviously reduce alloxan type hyperglycemic rat blood sugar level, improves insulin level, and is remarkable with the model group comparing difference.
Three,
Chinese medicine of the present invention is to the influence of the little blood sugar content of normal mice
Get 50 of mices, male and female half and half are divided into 5 groups at random. and 10 every group.Be respectively the normal control group, Chinese medicine of the present invention high, medium and low (0.64,0.32,0.16 g/kg) group, ginseng stilbene Chinese medicine of the present invention (0.6 g/kg).The normal control group is steamed water, and all the other respectively organize equal gastric infusion, and capacity is 0.1ml/kg, every day 1 time, 15d continuously.Water 12d is can't help in fasting before the last administration, 1.5h after the last administration, and the vena ophthalmica clump is got blood, adopts the determination of glucose oxidase serum glucose level.The result sees table 3
The result shows that Chinese drug-treated group of the present invention do not have obvious influence to normal mouse blood sugar.
Four,
Chinese medicine of the present invention is to the influence of glucose tolerance
Get 50 of mices, divide into groups with experiment three.All the other respectively organize equal gastric infusion, and capacity is 0.2ml/kg, and the normal control group is steamed water.Every day 1 time, 15d continuously.Water 12d is can't help in fasting before the last administration, 1.5h after the last administration, and each group is irritated stomach glucose solution 2g/kg, respectively at 0,0.5,1,2h vena ophthalmica clump gets blood, measures blood sugar level.The result sees table 4.
The result shows that Chinese drug-treated group of the present invention do not have obvious influence to normal mouse blood sugar tolerance.
The specific embodiment
1 gets Radix Astragali 500g, Rhizoma Polygonati 300g, Rhizoma Polygonati Odorati 300g, Cortex Lycii 400g, Rhizoma Dioscoreae 200g, Rhizoma Alismatis 200g, Radix Et Rhizoma Fagopyri Tatarici 110g, dextrin 15g;
2, with step 1 get the Radix Astragali,, Rhizoma Polygonati,, Rhizoma Polygonati Odorati,, Cortex Lycii,, Rhizoma Dioscoreae,, Rhizoma Alismatis mixes, and adds 8 times of water loggings bubbles of medical material weight 1h, decocts 2h again, filters filtrate for later use;
3, the medicinal residues that step 2 leached add the water with step 2 equivalent again, decoct 2h again, filter, and must filtrate;
4, combining step 2,3 gained filtrating, quiescent setting 6h gets the supernatant centrifugal treating;
5, will under 70-80 ℃, 0.075-0.085Mpa condition, be evaporated to the thick extractum of 60 ℃ of lower density 120-130 through medicinal liquid that step 4 is handled;
6, step 1 being got Radix Et Rhizoma Fagopyri Tatarici sterilizes with the 5kgy amount of radiation with cobalt 60;
7, will be broken into 80-100 purpose fine powder through the Radix Et Rhizoma Fagopyri Tatarici powder of step 6 sterilization;
8, the thick extractum with step 5 gained mixes with the Radix Et Rhizoma Fagopyri Tatarici powder of step 7 gained, concentrating under reduced pressure under 70-80 ℃, 0.075-0.085Mpa condition, dry extract shape blood-sugar lowering tcm drug;
9, step 8 gained dry extract is broken into extract powder and mixes with dextrine powder, divide to be filled in 1000 capsules, powder charge 0.45g gets blood-sugar lowering tcm drug capsule of the present invention in every capsules.
Claims (4)
1. hypoglycemic Chinese medicine is characterized in that: the extract and the Radix Et Rhizoma Fagopyri Tatarici powder 10-12 weight portion that are mixed back water boiling and extraction or alcohol reflux by Radix Astragali 45-55 weight portion, Rhizoma Polygonati 28-32 weight portion, Rhizoma Polygonati Odorati 28-32 weight portion, Cortex Lycii 38-42 weight portion, Rhizoma Dioscoreae 18-22 weight portion, Rhizoma Alismatis 18-22 weight portion are formed medicinal active ingredient.
2. a kind of hypoglycemic Chinese medicine according to claim 1 is characterized in that the medical material usage ratio is: the Radix Astragali 50 weight portions, Rhizoma Polygonati 30 weight portions, Rhizoma Polygonati Odorati 30 weight portions, Cortex Lycii 40 weight portions, Rhizoma Dioscoreae 20 weight portions, Rhizoma Alismatis 20 weight portions, Radix Et Rhizoma Fagopyri Tatarici 11 weight portions.
3. claim 1 or 2 blood sugar lowering preparation method of Chinese medicine may further comprise the steps
(1) gets Radix Astragali 45-55 weight portion, Rhizoma Polygonati 28-32 weight portion, Rhizoma Polygonati Odorati 28-32 weight portion, Cortex Lycii 38-42 weight portion, Rhizoma Dioscoreae 18-22 weight portion, Rhizoma Alismatis 18-22 weight portion, Radix Et Rhizoma Fagopyri Tatarici 10-12 weight portion;
(2) step (1) Radix Astragali of getting, Rhizoma Polygonati, Rhizoma Polygonati Odorati, Cortex Lycii, Rhizoma Dioscoreae, Rhizoma Alismatis are mixed, add 8 times of water logging bubbles of medical material weight 1h, decoct 2h again, filter filtrate for later use;
(3) medicinal residues that step (2) leached add the water with step (2) equivalent again, decoct 2h again, filter, and must filtrate;
(4) combining step (2), (3) gained filtrating, quiescent setting 6h gets the supernatant centrifugal treating;
(5) will under 70-80 ℃, 0.075-0.085Mpa condition, be evaporated to the thick extractum of 60 ℃ of lower density 1.20-1.30 through medicinal liquid that step (4) is handled;
(6) step (1) Radix Et Rhizoma Fagopyri Tatarici of getting is sterilized with the 5kgy amount of radiation with cobalt 60;
(7) will be broken into 80-100 purpose fine powder through the Radix Et Rhizoma Fagopyri Tatarici powder of step (6) sterilization;
(8) the thick extractum with step (5) gained mixes with the Radix Et Rhizoma Fagopyri Tatarici powder of step (7) gained, concentrating under reduced pressure under 70-80 ℃, 0.075-0.085Mpa condition, dry extract shape blood-sugar lowering tcm drug;
(9) step (8) gained dry extract is broken into extract powder and mixes with dextrine powder 1.5 weight portions, encapsulated, get blood-sugar lowering tcm drug capsule of the present invention, or, process conventional peroral dosage form extract powder and other pharmaceutical carrier commonly used or mixed with excipients.
4. claim 1 or 2 blood sugar lowering preparation method of Chinese medicine may further comprise the steps
(1) gets Radix Astragali 45-55 weight portion, Rhizoma Polygonati 28-32 weight portion, Rhizoma Polygonati Odorati 28-32 weight portion, Cortex Lycii 38-42 weight portion, Rhizoma Dioscoreae 18-22 weight portion, Rhizoma Alismatis 18-22 weight portion, Radix Et Rhizoma Fagopyri Tatarici 10-12 weight portion;
(2) step (1) Radix Astragali of getting, Rhizoma Polygonati, Rhizoma Polygonati Odorati, Cortex Lycii, Rhizoma Dioscoreae, Rhizoma Alismatis are mixed; Add medical material weight 10-20 doubly, concentration is 50~90% alcohol reflux 2~4 times; Each time is 0.5~3h; Reclaim ethanol, merge extractive liquid, is evaporated to extracting solution the thick extractum of 60 ℃ of lower density 1.20-1.30 under 70-80 ℃, 0.075-0.085Mpa condition;
(3) step (1) Radix Et Rhizoma Fagopyri Tatarici of getting is sterilized with the 5kgy amount of radiation with cobalt 60;
(4) will be broken into 80-100 purpose fine powder through the Radix Et Rhizoma Fagopyri Tatarici powder of step (3) sterilization;
(5) the thick extractum with step (2) gained mixes with the Radix Et Rhizoma Fagopyri Tatarici powder of step (4) gained, concentrating under reduced pressure under 70-80 ℃, 0.075-0.085Mpa condition, dry extract shape blood-sugar lowering tcm drug;
(6) step (5) gained dry extract is broken into extract powder and mixes with dextrine powder 1.5 weight portions, encapsulated, get blood-sugar lowering tcm drug capsule of the present invention, or, process conventional peroral dosage form extract powder and other pharmaceutical carrier commonly used or mixed with excipients.
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Cited By (5)
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CN103315221A (en) * | 2013-05-30 | 2013-09-25 | 宁国市亿邦生物科技有限公司 | Instant powder having auxiliary blood sugar-reduction effect and preparation method thereof |
CN104083578A (en) * | 2014-07-14 | 2014-10-08 | 上海浦东高星生物技术研究所 | Chinese patent medicine for promoting urination and reducing blood sugar |
CN105685754A (en) * | 2016-01-20 | 2016-06-22 | 哈尔滨瑞烨环保科技有限公司 | Inonotuso bliquus pilat compound solid beverage as well as preparation method and application thereof |
CN105918572A (en) * | 2016-06-23 | 2016-09-07 | 冯世英 | Brewing bag type blood glucose lowering tea |
CN108523129A (en) * | 2018-05-14 | 2018-09-14 | 珠海联邦制药股份有限公司 | A kind of auxiliary hyperglycemic composition and preparation method thereof |
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Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103315221A (en) * | 2013-05-30 | 2013-09-25 | 宁国市亿邦生物科技有限公司 | Instant powder having auxiliary blood sugar-reduction effect and preparation method thereof |
CN104083578A (en) * | 2014-07-14 | 2014-10-08 | 上海浦东高星生物技术研究所 | Chinese patent medicine for promoting urination and reducing blood sugar |
CN105685754A (en) * | 2016-01-20 | 2016-06-22 | 哈尔滨瑞烨环保科技有限公司 | Inonotuso bliquus pilat compound solid beverage as well as preparation method and application thereof |
CN105918572A (en) * | 2016-06-23 | 2016-09-07 | 冯世英 | Brewing bag type blood glucose lowering tea |
CN108523129A (en) * | 2018-05-14 | 2018-09-14 | 珠海联邦制药股份有限公司 | A kind of auxiliary hyperglycemic composition and preparation method thereof |
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