CN101104056B - Medicine for treating lung carbuncle and its preparation method - Google Patents
Medicine for treating lung carbuncle and its preparation method Download PDFInfo
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- CN101104056B CN101104056B CN2006100897421A CN200610089742A CN101104056B CN 101104056 B CN101104056 B CN 101104056B CN 2006100897421 A CN2006100897421 A CN 2006100897421A CN 200610089742 A CN200610089742 A CN 200610089742A CN 101104056 B CN101104056 B CN 101104056B
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Abstract
The invention discloses the medicine and the preparation method for treating the pulmonary abscess. The invention firstly extract the ingredient of the coix seed oil in the coix seed by steam distillation, and ensures the stability of the ingredient of the volatile oil by the hydroxypropyl-Beta-cyclodextrin inclusion, then the distilled herb residues and the pharagmitis rhizoma are put into the container and are soaked by ethanol, the ethanol solution is recovered, and the polysaccharide mixture is extracted by hot water; and the peach seed and Chinese waxgourd semen are put into the hot water for extracting, so the effective ingredients can be obtained. The chief drug in the medicine of the invention can be made by mixing the effective ingredients extracted by the three steps, and then the solid preparation can be made by mixing the chief drug fixes with the proper pharmaceutical excipient. The extraction technique of the invention adopts the respective extraction method to better extract the effective ingredients of the four crude drugs in the prescription, thus the pharmacological action can be improved and the taking dosage can be reduced.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicine pharmacy, be specifically related to a kind of medicine for the treatment of lung carbuncle and preparation method thereof.
Background technology
Lung abscess belongs to the disease of tcm saying, is to stop up lung by pyretic toxicity, due to the phlegm and blood stasis.Phlegm-heat obstructing in the lung, gas lose clear respectful then cough with copious phlegm; " interior warp " said: " then meat corruption of intenseness of heat, the meat corruption then becomes pus ", pathogenic heat are violated lung, injure blood vessels, and pyrogenicity is stopped up blood stasis, blood loses the meat corruption if do not dissipate then for a long time, is into lung abscess; The pus of carbuncle diabrosis, excuse is swallowed and is gone out, and tells stench yellow sputum pus and blood so cough; The hot congestion of expectorant, mutual resistance in the heart, thereby dull pain in the heart; Red tongue with yellowish and greasy fur, slippery and rapid pulse be resembling of expectorant Re Neisheng all.Control and work as removing heat from the lung and dissipating phlegm, the removing blood stasis evacuation of pus.
Weijing decoction is made up of Rhizoma Phragmitis, Semen Coicis, Semen Benincasae and Semen Persicae four flavor Chinese medicines, is the good recipe of treatment lung abscess.The Fang Yuan of weijing decoction comes from Prescriptions Worth Thousand Gold for Emergencies, " medical secrets of official " volume ten " lung abscess sides ", and drawing " record is at all times tested " also has weijing decoction.Rhizoma Phragmitis is sweet cold frivolous in the side, kind clearing away lung-heat, and " herbal classic is met the source " meaning: " specially in sharp key, the kind lung abscess, vomiting bloody pus fetid sputum controlled ", so the product that must use for lung abscess are with thinking monarch.The Semen Benincasae removing heat-phlegm, promoting diuresis and pus discharge can be last clearly thorough following, and the respectful lung qi that falls cooperates then lung heat clearing a surname to stop up the clearing away phlegm evacuation of pus with Rhizoma Phragmitis; Sweet light being slightly cold of Semen Coicis, last clearing away lung-heat and evacuation of pus, diarrhea the intestines and stomach and eliminating dampness by diuresis, the two is ministerial drug altogether.The Semen Persicae blood circulation and removing stasis can help eliminating carbuncle, is to be adjuvant drug.The side is four medicines only, and of a tightly knit structure, the property of medicine is gentle, altogether the effect of tool removing heat-phlegm, removing blood stasis evacuation of pus.
What the traditional extraction process of weijing decoction adopted is that decocting boils, at present few to the further investigation of weijing decoction, in the weijing decoction four flavor Chinese medicine, contain a large amount of Rhizoma Phragmitis polysaccharide in the Rhizoma Phragmitis, contain in the Semen Coicis in Semen Coicis polysaccharide and the Semen Coicis oil Semen Persicae and contain amygdaloside, traditional extracting method is taken after simply four flavor Chinese medicine waters being decocted, cause the effective ingredient that extracts smudgy, simple proposition water-soluble components, certainly will cause having omitted a lot of other polar effective ingredient, reduce we's pharmacological action.
Summary of the invention
For these reasons, research worker of the present invention is through great deal of experimental, at first Semen Coicis is extracted wherein Semen Coicis oil with steam distillation, and with the HP-enclose to guarantee the stability of volatile oil component, medicinal residues and Rhizoma Phragmitis after will extracting are then put into the container soak with ethanol, reclaim alcoholic solution, use the hot water extraction polysaccharide mixture; With extracting in Semen Persicae, the Semen Benincasae adding hot water, obtain effective ingredient.The effective ingredient that this three step is extracted mixes the principal agent that promptly gets in the medicine of the present invention, and principal agent and the pharmaceutic adjuvant that suits are mixed and made into solid preparation.Extraction process of the present invention fully takes into account the different characteristics of the contained active ingredient of four flavor Chinese medicines in the prescription, takes to extract respectively and can better extracts active ingredients wherein be come out, and improves pharmacological action, reduces taking dose.
The medicine that the purpose of this invention is to provide the treatment lung carbuncle of a kind of taking convenience, bioavailability height, better efficacy.
Another object of the present invention provides a kind of medicine for the treatment of lung carbuncle and preparation method thereof.
The present invention is achieved through the following technical solutions:
One, preparation technology
(1) prescription crude drug weight proportion is:
Rhizoma Phragmitis 20-180 weight portion, Semen Coicis 10-90 weight portion, Semen Benincasae 8-72 weight portion, Semen Persicae 3-27 weight portion;
(2) preparation of principal agent:
A. with the Semen Coicis pulverizing medicinal materials of above-mentioned weight portion, added water retting 1-3 hour that 5-10 doubly measures, vapor distillation extracted 2-4 hour, collected volatile oil, with 20-50 HP-enclose doubly, obtained effective constituents A; Aqueous solution and medicinal residues are continued to employ;
B. with the Rhizoma Phragmitis pulverizing medicinal materials of above-mentioned weight portion, be placed in the extraction vessel with medicinal residues among the step a, add soak with ethanol 24-48 hour of 75%-95%, reclaim ethanol, add 6-10 times of water gaging and decocted 1-3 hour, extract 1-2 time, with the aqueous solution merging of the aqueous solution among the step a and this extraction, filter, filtrate decompression is concentrated into the 1/8-1/10 volume, and 20%-45% ethanol is joined in the concentrated solution, and room temperature was placed 6-12 hour, sucking filtration, collecting precipitation; Add ethanol in the supernatant and make and contain the alcohol amount and reach 50%-70%, room temperature was placed 12-24 hour, sucking filtration, and collecting precipitation merges the precipitate of twice collection, obtains effective site B;
C. with Semen Persicae, the Semen Benincasae pulverizing medicinal materials of above-mentioned weight portion, the water heating extraction of doubly measuring with 4-10 1-3 time, each 2-4 hour, collect extracting solution, filter, merging filtrate is concentrated into relative density 1.0-1.5, obtains effective site C;
Principal agent in the medicine of the present invention is made up of effective site A, effective site B and effective site C.
(3) preparation prescription:
Tablet formulation consists of: principal agent 5-20 weight portion, pharmaceutic adjuvant are the 2.5-60 weight portion;
The granule prescription consists of: principal agent 5-20 weight portion, pharmaceutic adjuvant 10-160 weight portion;
The capsule prescription consists of: principal agent 5-20 weight portion, pharmaceutic adjuvant are the 2.5-60 weight portion;
The soft capsule prescription consists of: principal agent 5-20 weight portion, pharmaceutic adjuvant are the 5-80 weight portion;
The drop pill prescription consists of: principal agent 5-20 weight portion, pharmaceutic adjuvant are the 10-160 weight portion;
(4) formulation preparation:
Get principal agent, add acceptable pharmaceutic adjuvant on the pharmaceutics, be prepared into tablet, granule, capsule, soft capsule, drop pill with conventional pharmaceutical technology;
Two, pharmacology embodiment
In order to confirm the therapeutic effect of medicine of the present invention, research worker of the present invention has been carried out following pharmacodynamics test to said preparation.
Reagent and animal: weijing decoction (getting) by the traditional handicraft water boiling and extraction; Medicine of the present invention (by preparation technology's preparation of the present invention, uniting big magnificent Pharmaceutical Chinese medicine laboratory by Beijing provides); The Wistar rat, body weight 180-220g; Healthy Kunming mouse, body weight 18-22g;
1. to the influence of Oleum Tiglii induced mice auricle edema
Get 30 of healthy mices, be divided into 3 groups at random, be the blank group, weijing decoction positive controls, drug test group of the present invention, every group 10, male and female half and half, positive controls and test group are gastric infusion (ig) 8g crude drug/kg respectively, and the blank group is irritated the isodose normal saline of stomach, successive administration 3 days, after the last administration 0.5 hour, be coated with Oleum Tiglii proinflammatory agent (2% Oleum Tiglii, 20% dehydrated alcohol in the outer survey of in ear of a mice left side, 5% distilled water, 73% ether) 0.1ml causes inflammation, causes scorching back 4 hours with macropore device (aperture 6mm) and lays a left side, the auris dextra sheet is weighed, as the swelling degree, the results are shown in Table 1 with left and right sides auricle weight difference.
The influence of table 1 pair Oleum Tiglii induced mice auricle edema
Annotate: compare with the blank group: * P＜0.01; Compare with the weijing decoction positive controls: * * P＜0.05;
By last table experimental result as can be seen, pharmaceutical preparation group of the present invention has better pharmacological action.
2. the influence of rat paw edema due to the on Carrageenan
Get 30 of healthy rats, body weight 180-220g is divided into the blank group at random, weijing decoction positive controls, drug test group of the present invention, 10 every group, male and female half and half, sub-cage rearing.Positive controls and test group be gastric infusion 8g crude drug/kg respectively, the normal saline that the blank group deturs talis dosis, successive administration 3 days, after the last administration 30 minutes, only cause inflammation at the right back sufficient plantar subcutaneous injection 1% carrageenin suspension 0.1ml/ of rat respectively, respectively at cause scorching before and cause the girth that scorching back was surveyed the right back sufficient sole of the foot of rat in 15,30,60,120 minutes, and calculate swelling rate [swelling rate=(cause scorching metapedes sole of the foot girth-cause scorching front foot sole of the foot girth)/cause scorching front foot sole of the foot girth * 100%]; The results are shown in Table 2.
The influence of rat paw edema due to table 2 on Carrageenan
Annotate: compare with the blank group: * P＜0.01; Compare with the weijing decoction positive controls: * * P＜0.05;
By last table experimental result as can be seen, pharmaceutical preparation group of the present invention has better pharmacological action.
3. mouse tail vein is infected the effect of bacillus pyocyaneus
Get 30 of healthy mices, be divided into 3 groups at random, i.e. blank group, the weijing decoction positive controls, drug test group of the present invention, 10 every group, male and female half and half adopt clinical isolating bacillus pyocyaneus, after the prerun with 1 * 10
-1Every mouse tail vein injection 0.2ml of concentration, the mouse infection bacillus pyocyaneus is irritated stomach simultaneously and gives weijing decoction positive controls and drug test group of the present invention (5g crude drug/kg), successive administration 3 days, observed and recorded 7 days, the blank group was irritated stomach 1%CMC-Na solution 0.8ml totally 3 days every day, write down 7 days; The results are shown in Table 3.
Table 3 pair mouse tail vein infects the effect of bacillus pyocyaneus
Annotate: compare with the blank group: * * P＜0.01; Compare with the weijing decoction positive controls: #P＜0.05;
By last table experimental result as can be seen, pharmaceutical preparation group of the present invention has better pharmacological action.
4. acute toxicity testing
Get 40 of healthy mices, body weight 18-22g,, male and female half and half.Be divided into the weijing decoction positive controls, drug test group of the present invention, the tail intravenously administrable, dosage is according to 50 times of people's dosage, be converted into the mice dosage according to body surface area, administration every day 1 time, continuous 7 days, observe the dead mouse situation, record data, experimental result sees Table 4.
Table 4 chmice acute toxicity test
Above-mentioned experimental result shows: pharmaceutical preparation group of the present invention has good safety.
Three, preparation embodiment
Embodiment 1
(1) preparation of principal agent:
A. with 500g Semen Coicis pulverizing medicinal materials, add the water retting 1 hour of 5 times of amounts, vapor distillation extracted 2 hours, collected volatile oil, and the HP-enclose with 20 times obtains effective constituents A; Aqueous solution and medicinal residues are continued to employ;
B. with 1000g Rhizoma Phragmitis pulverizing medicinal materials, be placed in the extraction vessel with medicinal residues among the step a, added 75% soak with ethanol 24 hours, reclaim ethanol, add 6 times of water gagings and decocted 1 hour, extract 1 time, with the aqueous solution merging of the aqueous solution among the step a and this extraction, filter, filtrate decompression is concentrated into 1/8 volume, and 20% ethanol is joined in the concentrated solution, and room temperature was placed 6 hours, sucking filtration, collecting precipitation; Add ethanol in the supernatant and make and contain the alcohol amount and reach 50%, room temperature was placed 12 hours, sucking filtration, and collecting precipitation merges the precipitate of twice collection, obtains effective site B;
C. with 150g Semen Persicae, 400g Semen Benincasae pulverizing medicinal materials, with the water heating extraction of 4 times of amounts 1 time, 2 hours extraction times, collect extracting solution, filter, merging filtrate is concentrated into relative density 1.0, obtains effective site C;
Principal agent in the medicine of the present invention is made up of effective site A, effective site B and effective site C.
(2) preparation prescription:
Tablet formulation consists of: principal agent 50g, pharmaceutic adjuvant are 25g;
The granule prescription consists of: principal agent 10g, pharmaceutic adjuvant 60g;
The capsule prescription consists of: principal agent 15g, pharmaceutic adjuvant are 45g;
The soft capsule prescription consists of: principal agent 12g, pharmaceutic adjuvant are 36g;
The drop pill prescription consists of: principal agent 20g, pharmaceutic adjuvant are 140g;
(3) formulation preparation:
Form according to preparation prescription, be prepared into 1000 in tablet, 1000 bags of granules, 1000 of capsules, 1000 of soft capsules, 1000 bags of drop pills with conventional pharmaceutical technology.
Embodiment 2
(1) preparation of principal agent:
A. with 250g Semen Coicis pulverizing medicinal materials, add the water retting 1.5 hours of 6 times of amounts, vapor distillation extracted 2.5 hours, collected volatile oil, and the HP-enclose with 25 times obtains effective constituents A; Aqueous solution and medicinal residues are continued to employ;
B. with 500g Rhizoma Phragmitis pulverizing medicinal materials, be placed in the extraction vessel with medicinal residues among the step a, added 80% soak with ethanol 30 hours, reclaim ethanol, add 7 times of water gagings and decocted 1.5 hours, extract 2 times, with the aqueous solution merging of the aqueous solution among the step a and this extraction, filter, filtrate decompression is concentrated into 1/9 volume, and 25% ethanol is joined in the concentrated solution, and room temperature was placed 7 hours, sucking filtration, collecting precipitation; Add ethanol in the supernatant and make and contain the alcohol amount and reach 55%, room temperature was placed 15 hours, sucking filtration, and collecting precipitation merges the precipitate of twice collection, obtains effective site B;
C. with 75g Semen Persicae, 200g Semen Benincasae pulverizing medicinal materials, with the water heating extraction of 5 times of amounts 2 times, each 2.5 hours, collect extracting solution, filter, merging filtrate is concentrated into relative density 1.1, obtains effective site C;
Principal agent in the medicine of the present invention is made up of effective site A, effective site B and effective site C.
(2) preparation prescription:
Tablet formulation consists of: principal agent 25g, pharmaceutic adjuvant are 20g;
The granule prescription consists of: principal agent 8g, pharmaceutic adjuvant 45g;
The capsule prescription consists of: principal agent 12g, pharmaceutic adjuvant are 36g;
The soft capsule prescription consists of: principal agent 10g, pharmaceutic adjuvant are 30g;
The drop pill prescription consists of: principal agent 15g, pharmaceutic adjuvant are 80g;
(3) formulation preparation:
Form according to preparation prescription, be prepared into 1000 in tablet, 1000 bags of granules, 1000 of capsules, 1000 of soft capsules, 1000 bags of drop pills with conventional pharmaceutical technology.
Embodiment 3
(1) preparation of principal agent:
A. with 1000g Semen Coicis pulverizing medicinal materials, add the water retting 3 hours of 10 times of amounts, vapor distillation extracted 4 hours, collected volatile oil, and the HP-enclose with 50 times obtains effective constituents A; Aqueous solution and medicinal residues are continued to employ;
B. with 2000g Rhizoma Phragmitis pulverizing medicinal materials, be placed in the extraction vessel with medicinal residues among the step a, added 95% soak with ethanol 48 hours, reclaim ethanol, add 10 times of water gagings and decocted 3 hours, extract 2 times, with the aqueous solution merging of the aqueous solution among the step a and this extraction, filter, filtrate decompression is concentrated into 1/10 volume, and 45% ethanol is joined in the concentrated solution, and room temperature was placed 12 hours, sucking filtration, collecting precipitation; Add ethanol in the supernatant and make and contain the alcohol amount and reach 70%, room temperature was placed 24 hours, sucking filtration, and collecting precipitation merges the precipitate of twice collection, obtains effective site B;
C. with 300g Semen Persicae, 800g Semen Benincasae pulverizing medicinal materials, with the water heating extraction of 10 times of amounts 3 times, each 4 hours, collect extracting solution, filter, merging filtrate is concentrated into relative density 1.5, obtains effective site C;
Principal agent in the medicine of the present invention is made up of effective site A, effective site B and effective site C.
(2) preparation prescription:
Tablet formulation consists of: principal agent 80g, pharmaceutic adjuvant are 65g;
The granule prescription consists of: principal agent 30g, pharmaceutic adjuvant 150g;
The capsule prescription consists of: principal agent 40g, pharmaceutic adjuvant are 135g;
The soft capsule prescription consists of: principal agent 35g, pharmaceutic adjuvant are 110g;
The drop pill prescription consists of: principal agent 50g, pharmaceutic adjuvant are 320g;
(3) formulation preparation:
Form according to preparation prescription, be prepared into 1000 in tablet, 1000 bags of granules, 1000 of capsules, 1000 of soft capsules, 1000 bags of drop pills with conventional pharmaceutical technology.
Embodiment 4
(1) preparation of principal agent:
A. with 100g Semen Coicis pulverizing medicinal materials, add the water retting 2.5 hours of 9 times of amounts, vapor distillation extracted 3.5 hours, collected volatile oil, and the HP-enclose with 45 times obtains effective constituents A; Aqueous solution and medicinal residues are continued to employ;
B. with 150g Rhizoma Phragmitis pulverizing medicinal materials, be placed in the extraction vessel with medicinal residues among the step a, added 90% soak with ethanol 45 hours, reclaim ethanol, add 9 times of water gagings and decocted 2.5 hours, extract 2 times, with the aqueous solution merging of the aqueous solution among the step a and this extraction, filter, filtrate decompression is concentrated into 1/10 volume, and 40% ethanol is joined in the concentrated solution, and room temperature was placed 10 hours, sucking filtration, collecting precipitation; Add ethanol in the supernatant and make and contain the alcohol amount and reach 65%, room temperature was placed 15 hours, sucking filtration, and collecting precipitation merges the precipitate of twice collection, obtains effective site B;
C. with 30g Semen Persicae, 75g Semen Benincasae pulverizing medicinal materials, with the water heating extraction of 9 times of amounts 2 times, each 3.5 hours, collect extracting solution, filter, merging filtrate is concentrated into relative density 1.4, obtains effective site C;
Principal agent in the medicine of the present invention is made up of effective site A, effective site B and effective site C.
(2) preparation prescription:
Tablet formulation consists of: principal agent 15g, pharmaceutic adjuvant are 40g;
The granule prescription consists of: principal agent 12g, pharmaceutic adjuvant 96g;
The capsule prescription consists of: principal agent 40g, pharmaceutic adjuvant are 20g;
The soft capsule prescription consists of: principal agent 25g, pharmaceutic adjuvant are 100g;
The drop pill prescription consists of: principal agent 15g, pharmaceutic adjuvant are 60g;
(3) formulation preparation:
Form according to preparation prescription, be prepared into 1000 in tablet, 1000 bags of granules, 1000 of capsules, 1000 of soft capsules, 1000 bags of drop pills with conventional pharmaceutical technology.
Embodiment 5
(1) preparation of principal agent:
A. with 200g Semen Coicis pulverizing medicinal materials, add the water retting 2 hours of 8 times of amounts, vapor distillation extracted 3 hours, collected volatile oil, and the HP-enclose with 40 times obtains effective constituents A; Aqueous solution and medicinal residues are continued to employ;
B. with 500g Rhizoma Phragmitis pulverizing medicinal materials, be placed in the extraction vessel with medicinal residues among the step a, added 85% soak with ethanol 30 hours, reclaim ethanol, add 8 times of water gagings and decocted 2 hours, extract 2 times, with the aqueous solution merging of the aqueous solution among the step a and this extraction, filter, filtrate decompression is concentrated into 1/8 volume, and 30% ethanol is joined in the concentrated solution, and room temperature was placed 8 hours, sucking filtration, collecting precipitation; Add ethanol in the supernatant and make and contain the alcohol amount and reach 60%, room temperature was placed 20 hours, sucking filtration, and collecting precipitation merges the precipitate of twice collection, obtains effective site B;
C. with 50g Semen Persicae, 180g Semen Benincasae pulverizing medicinal materials, with the water heating extraction of 8 times of amounts 2 times, each 3 hours, collect extracting solution, filter, merging filtrate is concentrated into relative density 1.2, obtains effective site C;
Principal agent in the medicine of the present invention is made up of effective site A, effective site B and effective site C.
(2) preparation prescription:
Tablet formulation consists of: principal agent 20g, pharmaceutic adjuvant are 50g;
The granule prescription consists of: principal agent 25g, pharmaceutic adjuvant 120g;
The capsule prescription consists of: principal agent 80g, pharmaceutic adjuvant are 45g;
The soft capsule prescription consists of: principal agent 50g, pharmaceutic adjuvant are 150g;
The drop pill prescription consists of: principal agent 35g, pharmaceutic adjuvant are 70g;
(3) formulation preparation:
Form according to preparation prescription, be prepared into 1000 in tablet, 1000 bags of granules, 1000 of capsules, 1000 of soft capsules, 1000 bags of drop pills with conventional pharmaceutical technology.
Embodiment 6
(1) preparation of principal agent:
A. with 250g Semen Coicis pulverizing medicinal materials, add the water retting 2 hours of 7 times of amounts, vapor distillation extracted 2 hours, collected volatile oil, and the HP-enclose with 30 times obtains effective constituents A; Aqueous solution and medicinal residues are continued to employ;
B. with 600g Rhizoma Phragmitis pulverizing medicinal materials, be placed in the extraction vessel with medicinal residues among the step a, added 80% soak with ethanol 40 hours, reclaim ethanol, add 8 times of water gagings and decocted 2 hours, extract 2 times, with the aqueous solution merging of the aqueous solution among the step a and this extraction, filter, filtrate decompression is concentrated into 1/8 volume, and 35% ethanol is joined in the concentrated solution, and room temperature was placed 9 hours, sucking filtration, collecting precipitation; Add ethanol in the supernatant and make and contain the alcohol amount and reach 60%, room temperature was placed 18 hours, sucking filtration, and collecting precipitation merges the precipitate of twice collection, obtains effective site B;
C. with 80g Semen Persicae, 150g Semen Benincasae pulverizing medicinal materials, with the water heating extraction of 5 times of amounts 2 times, each 3 hours, collect extracting solution, filter, merging filtrate is concentrated into relative density 1.3, obtains effective site C;
Principal agent in the medicine of the present invention is made up of effective site A, effective site B and effective site C.
(2) preparation prescription:
Tablet formulation consists of: principal agent 30g, pharmaceutic adjuvant are 75g;
The granule prescription consists of: principal agent 35g, pharmaceutic adjuvant 150g;
The capsule prescription consists of: principal agent 75g, pharmaceutic adjuvant are 40g;
The soft capsule prescription consists of: principal agent 15g, pharmaceutic adjuvant are 100g;
The drop pill prescription consists of: principal agent 30g, pharmaceutic adjuvant are 120g;
(3) formulation preparation:
Form according to preparation prescription, be prepared into 1000 in tablet, 1000 bags of granules, 1000 of capsules, 1000 of soft capsules, 1000 bags of drop pills with conventional pharmaceutical technology.
Embodiment 7
(1) preparation of principal agent:
A. with 750g Semen Coicis pulverizing medicinal materials, add the water retting 1 hour of 8 times of amounts, vapor distillation extracted 2 hours, collected volatile oil, and the HP-enclose with 35 times obtains effective constituents A; Aqueous solution and medicinal residues are continued to employ;
B. with 1800g Rhizoma Phragmitis pulverizing medicinal materials, be placed in the extraction vessel with medicinal residues among the step a, added 75% soak with ethanol 24 hours, reclaim ethanol, add 6 times of water gagings and decocted 3 hours, extract 2 times, with the aqueous solution merging of the aqueous solution among the step a and this extraction, filter, filtrate decompression is concentrated into 1/10 volume, and 40% ethanol is joined in the concentrated solution, and room temperature was placed 6 hours, sucking filtration, collecting precipitation; Add ethanol in the supernatant and make and contain the alcohol amount and reach 50%, room temperature was placed 12 hours, sucking filtration, and collecting precipitation merges the precipitate of twice collection, obtains effective site B;
C. with 200g Semen Persicae, 600g Semen Benincasae pulverizing medicinal materials, with the water heating extraction of 7 times of amounts 1 time, 2 hours extraction times, collect extracting solution, filter, merging filtrate is concentrated into relative density 1.4, obtains effective site C;
Principal agent in the medicine of the present invention is made up of effective site A, effective site B and effective site C.
(2) preparation prescription:
Tablet formulation consists of: principal agent 75g, pharmaceutic adjuvant are 150g;
The granule prescription consists of: principal agent 40g, pharmaceutic adjuvant 120g;
The capsule prescription consists of: principal agent 150g, pharmaceutic adjuvant are 60g;
The soft capsule prescription consists of: principal agent 50g, pharmaceutic adjuvant are 250g;
The drop pill prescription consists of: principal agent 60g, pharmaceutic adjuvant are 300g;
(3) formulation preparation:
Form according to preparation prescription, be prepared into 1000 in tablet, 1000 bags of granules, 1000 of capsules, 1000 of soft capsules, 1000 bags of drop pills with conventional pharmaceutical technology.
Claims (1)
1. preparation method for the treatment of the lung carbuncle medicine is characterized in that may further comprise the steps:
(1) preparation of principal agent:
A. press the Rhizoma Phragmitis of 20-180 weight portion, the Semen Coicis of 10-90 weight portion, the Semen Benincasae of 8-72 weight portion and the Semen Persicae weighting raw materials of 3-27 weight portion;
B. with the Semen Coicis pulverizing medicinal materials that takes by weighing among the step a, added water retting 1-3 hour that 5-10 doubly measures, vapor distillation extracted 2-4 hour, collected volatile oil, with 20-50 HP-enclose doubly, obtained effective constituents A; Aqueous solution and medicinal residues are continued to employ;
C. with the Rhizoma Phragmitis pulverizing medicinal materials that takes by weighing among the step a, be placed in the extraction vessel with medicinal residues among the step b, add soak with ethanol 24-48 hour of 75%-95%, reclaim ethanol, add 6-10 times of water gaging and decocted 1-3 hour, extract 1-2 time, with the aqueous solution merging of the aqueous solution among the step b and this extraction, filter, filtrate decompression is concentrated into the 1/8-1/10 volume, and 20%-45% ethanol is joined in the concentrated solution, and room temperature was placed 6-12 hour, sucking filtration, collecting precipitation; Add ethanol in the supernatant and make and contain the alcohol amount and reach 50%-70%, room temperature was placed 12-24 hour, sucking filtration, and collecting precipitation merges the precipitate of twice collection, obtains effective site B;
D. with the Semen Persicae, the Semen Benincasae pulverizing medicinal materials that take by weighing among the step a, the water heating extraction of doubly measuring with 4-10 1-3 time, each 2-4 hour, collect extracting solution, filter, merging filtrate is concentrated into relative density 1.0-1.5, obtains effective site C;
Principal agent in the medicine is made up of effective site A, effective site B and effective site C;
(2) formulation preparation:
Tablet formulation consists of: principal agent 5-20 weight portion, pharmaceutic adjuvant are the 2.5-60 weight portion;
The granule prescription consists of: principal agent 5-20 weight portion, pharmaceutic adjuvant 10-160 weight portion;
The capsule prescription consists of: principal agent 5-20 weight portion, pharmaceutic adjuvant are the 2.5-60 weight portion;
The drop pill prescription consists of: principal agent 5-20 weight portion, pharmaceutic adjuvant are the 10-160 weight portion;
Get principal agent, add acceptable pharmaceutic adjuvant on the pharmaceutics, be prepared into tablet, granule, capsule or drop pill with conventional pharmaceutical technology.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN2006100897421A CN101104056B (en) | 2006-07-14 | 2006-07-14 | Medicine for treating lung carbuncle and its preparation method |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2006100897421A CN101104056B (en) | 2006-07-14 | 2006-07-14 | Medicine for treating lung carbuncle and its preparation method |
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| CN101104056A CN101104056A (en) | 2008-01-16 |
| CN101104056B true CN101104056B (en) | 2010-06-09 |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102671049A (en) * | 2012-05-19 | 2012-09-19 | 成都绿迪科技有限公司 | Traditional Chinese medicine combination for treating lung abscess |
| CN103263059B (en) * | 2013-05-23 | 2014-06-18 | 圣原健康产业有限公司 | Solid beverage for clearing away lung-heat, promoting diuresis, reducing phlegm and relieving cough and preparation method thereof |
| CN104274683A (en) * | 2014-10-30 | 2015-01-14 | 淄博夸克医药技术有限公司 | Traditional Chinese medicine composition for treating pulmonary abscess and preparation method and application thereof |
| CN108969491A (en) * | 2018-08-15 | 2018-12-11 | 扬州大学 | A kind of Coixol preparation and preparation method thereof |
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2006
- 2006-07-14 CN CN2006100897421A patent/CN101104056B/en active Active
Non-Patent Citations (1)
| Title |
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| 马岩松.中西医结合治愈16例肺脓肿的体会.第三届海峡两岸中西医结合学术研讨会论文集.2005,125. * |
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Assignee: Zhongshan star Pharmaceutical Technology Co., Ltd. Assignor: Beijing Xinghao Medical Co., Ltd. Contract record no.: 2011440000010 Denomination of invention: Medicine for treating lung carbuncle and its preparation method Granted publication date: 20100609 License type: Exclusive License Open date: 20080116 Record date: 20110104 |
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Effective date of registration: 20190731 Address after: 528437 17 health Road, national health base, Zhongshan Torch Development Zone, Zhongshan, Guangdong Patentee after: Guangdong star Pharmaceutical Co., Ltd. Address before: 100176 No. 18 Zhonghe street, Beijing economic and Technological Development Zone Patentee before: Beijing Xinghao Medical Co., Ltd. |